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<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JME7</accession>
    <name>A0A7K0JME7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur reduction protein DsrE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="13793" checksum="93ECB45841FFCB23" modified="2021-04-07" version="1">MALWSGDGDGAVLYVQTHGCSDLGRCATPFFLAASAAAMEVEVGIYFTMYGPQLLQKDVVEKVGPKGDRGQPLSYFIKQATDLGVRLWVCQPSLDLNDLSREDLIAPVEMIGGAAFNDLAMTASAVISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMF1</accession>
    <name>A0A7K0JMF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_00155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000005">
        <property type="protein sequence ID" value="MST31142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="24088" checksum="215D9E0AE92E436F" modified="2021-04-07" version="1">MTEIVADGVVKAFGGRRALDGVDLAVPAAELWGVVGADGAGKTTLLRCIAGLLRVDAGRVLPGRSGQERLGFAQQGFHLYADLTVEENVAFIGSLYGLGRAAAARSATELLGFAGLQDRRGSLAGELSGGMKQKLTLVCALLHRPPVLLLDEPTTGVDPLSRLEFWNLVEHLRVTGSTVLLTSAYFDEVERCDHVVYLDHGRVLAAGAPSALRGTHPSLEAAFLEMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMM8</accession>
    <name>A0A7K0JMM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">GHK86_00525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="61" mass="7043" checksum="3980EABB4510B854" modified="2021-04-07" version="1">MAKKALIIKAQRKPKYKVRAYTRCRRCGRPHSVFRKFGLCRICLRELAHAGEVPGVTKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMQ2</accession>
    <name>A0A7K0JMQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="33801" checksum="D1CF8F85C1E1AD70" modified="2021-04-07" version="1">MEFYAPGLKRWQTAEWTPARPDRFLPVSVTGSACALQCDHCQAKVLDGMISVKAGEDLFDLARRLKERGSDGLLVSGGSTRAGGVPLLSHLRHVPRIRSELGMRVIVHSGVVRPALAAALADSEVDGVMLDIIGADETIRDVYHLDLTAADFERSLALLSERQLRIIPHIVLGLHYGRFLGERDALEMVARYPVSTLILVVLVPLIGTPMSHLPPPPVDEVIGFFEEARLRLPTTRVNLGCARPMGPVKGVLDRAAVDLGLNGIAYPAEGVIEYARSRGLQPKLYEWCCSMSWAGDEAERLTEVSVEVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMS8</accession>
    <name>A0A7K0JMS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="18749" checksum="E78ABE666CD3CAD7" modified="2021-04-07" version="1">ADWEDRPWHHRRADALMDLIRAHTARLSGADRYLVHVVMTATGAEILGGEPLHPATTARIRCDCSTVTHWVGETGEPLHLGRKQRSWNLAQRRAITVRDRGRCRFPNCQRTHTDIHHVQPWQAGGPTDITNGILLCPHHHTLIHDGWTITGDINHTLVFRRPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNB7</accession>
    <name>A0A7K0JNB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029906051" evidence="2">
        <location>
            <begin position="40"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="105"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="535" mass="57656" checksum="C51B3D69DF809A5B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNB8</accession>
    <name>A0A7K0JNB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="149"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="392" mass="41748" checksum="12A425EF71482B7F" modified="2021-04-07" version="1">ADEGRPLHYGFSASWASARGQVLSGVAATGDFHQSMSLLGDPDWQRSSSPAELGRWLELLRGELEAGALGVGVLLGYAPRSDPAEFVALGRLAAEAGVPTYTHVRELVEADPTTPIDGSSEIAAAAAETGAHMHHCHVNSTSRRHVDRVLRTLDQARTEGSRVTLEAYPYGSGATAVGAVFLDPERLPRWGLTPDRIVLLPSGERVADAARLRQVRAEAPETACIVEVLDEGDPADVALLQRSLLFPDSCVASDAMPVIWPDGTMDTREWPLPPGGTTHPRTAGTFARALRTLVRESGSWSWLEAFRRCSYLPARVLDFAPAARTKGHLAPGADADIVVLDPATVTDTATYLDPTSPSVGVRHLFVAGVPVVRDGAIVPDAYPGRALRAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF2</accession>
    <name>A0A7K0JNF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000082">
        <property type="protein sequence ID" value="MST31496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="35916" checksum="2DD7E00877ACE0CB" modified="2021-04-07" version="1">MYLGTAGLHWRNITPPRSRGVGASELFEQASFLNRAMGWVTAWDPTTDRTTIFRTTNGGRSWTAIPGGFQTAAGGAATLVDLVSPQTAFEEHLEPTAPGMTLAVTTDSGRSWKVVFREPVPTPAGLPQRGPFLMPVTFVDAERGFAAAGLPPSGPQVRTAGFFATADGGSTWEPVSPPLPTTSAGCRARGTSAARCLYGLPVFTGPRRGALATVAAVGWRALVAFDLTTDAGIRWRRAALLRLPVAPRRSGLDYPLTSLSASSWWALGWSGRTATVDTTSSEGAHWITRRGVVPDGVPIGLSAIGPTDALLVVRGGRPGASTTRLLFTVDAGKRWAPLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI0</accession>
    <name>A0A7K0JNI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LppX_LprAFG lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LppX/LprAFG lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000006">
        <property type="protein sequence ID" value="MST31149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009830">
        <property type="entry name" value="LppX/LprAFG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07161">
        <property type="entry name" value="LppX_LprAFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029680368" evidence="2">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="230" mass="23583" checksum="89931A8D7ED51EC3" modified="2021-04-07" version="1">MPALRRLLAPAAVLAVAAACASCGNSSRPSATALLGEARTTLDEAPAVQFALTSSGVAGKGIDLVGGSGELSRPQSLKGTFQVSASGLDVSVKVLAVGTRFWAVLPFQTAYSRVSPSRFGLTDPAALLSAHHGLTSLLTDLAGTAHYQPSIRLDGELLDVVSGTVAGSEIPVLPDANPSRPVRLTVAIDPASHQVRRVTLAGPFTQATRSAHYVVTLTGYGRHVSISPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK0</accession>
    <name>A0A7K0JNK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_02080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000088">
        <property type="protein sequence ID" value="MST31518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="287"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="492" mass="53633" checksum="9A53A34193B010DC" modified="2021-04-07" version="1">MVDVRVTGDAVGAVEAPAPQPPVRARRNPHLRLRLLVGDTIALTAAWSPEIAVGTAGGAALRSTSLAIIAIWCTLVATYWLGLYRSRVCARPVEASLRMLVAALAGLAGAAGVEWLRHGTPVPAPVPSLVLATVALFAVRWRLTRWLRARRAEGRFLRTIVLVGRTDQVGSVCDLLDAEPELGYRVGAIATPAGDGEWRGLPRGTPDTIQPLATQSGASGLILVAGALDPAAAEQVVRRAMDQRLHVQLWPGVECLASWRLRVSPICQLPAFYVEPHRIAPWQAALKRTIDIVLSASLLAVLAPLMGTVAVLVKAQDGGPVFYRSRRVGRRGALIWVTKYRTMVPDAASMLDAVAALNERQGGPLFKASADPRVTRLGAALRASSLDELPQLFDVLRGAMSLVGPRPALPSEVEQFDEDFQRRHDMRPGITGLWQVEARDNPSFRAYRRLDLTYVDNWHPWLDFAILVTTVHAVTVRALHLLRRPAHRRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM5</accession>
    <name>A0A7K0JNM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000088">
        <property type="protein sequence ID" value="MST31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="304"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="515" mass="52972" checksum="6C3287C9FFD3C8FC" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM7</accession>
    <name>A0A7K0JNM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000097">
        <property type="protein sequence ID" value="MST31566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="22605" checksum="C0A405D14B549894" modified="2021-04-07" version="1">MPSLLTFTTDTLLVRPWADDVVDRLGFDPRSPYVEQFWLGILGPSTTWLLRRVAAGFDTAPDGFELPLGETARALGLGDGLGRNAPILRSVNRMIQFGMALATGEGELAVRRHLPPLARRHVDRLPPHLQEEHHRWQEAELRTTEEDQRRRCRQLALSLVELGEDPEAVEQQLLRWRYHPRLAHEAATWAARQVEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ2</accession>
    <name>A0A7K0JNQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Diguanylate cyclase DosC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Direct oxygen-sensing cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000103">
        <property type="protein sequence ID" value="MST31600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="6">
        <location>
            <begin position="185"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="321" mass="35181" checksum="FB8A9A2658B357B6" modified="2021-04-07" version="1">MLDERGSGRLVVTPPDRGLSWSDDDQRIFVGHAAAWAQVVATFVDDLNAMVREVPELRGYFDDEAAVERHRLQAASHLQGMLEDPRDPVPRLRSHQVGMAHIAAGVRPSWYVMAYNRIFPAVHQLEGPDVALPPLALIRRRWLWDNCVTLDAYHEELDRRAGTDPLTGLANRRAIEGAVLAGGRGRCALALLDLDGFKSLNDRLGHVHGDEVLSQLGRALNRAVRRSDLVGRLGGDEFCIWMPDVSAATVTDWCRRVVGALPLERLGLGISAGVALQPDDGEGFAELYEAADTALYRVKRAGKSGFALVASDVVPWGHPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU0</accession>
    <name>A0A7K0JNU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="260" mass="28777" checksum="6CF3FF0966ED8FE5" modified="2021-04-07" version="1">MTAVLEACGVGKHFTKDTSRIVALDACDLQIEEGTFVALLGRSGCGKSTLLNLFAGLSRPSRGEVRYRGTALGGLCPGVGYLTQADTLMPWRKLLRNIELPLELRGVDGDRRRRQAEDLIEMVGLKGYESHYPRELSGGMRRRASLARMLISDPELLLLDEPFGALDAQLRSDMQVELLRLWQGSGRSVVFVTHDIEEALVLGDRVVVLGQRGQVRLDVPVPLRRPRDLDDVRVDATFVELHRRLAAALREGSHDVVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY4</accession>
    <name>A0A7K0JNY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000115">
        <property type="protein sequence ID" value="MST31682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="12760" checksum="F95BF12C75A27A4F" modified="2021-04-07" version="1" fragment="single">MDRLVVLKALADDSRYAIFAELGRAERALSTVELAQRLDLHPNTVRLHLERLREAGLVHSSTEAHGAPGRPQHLWALTPDAPALGLEPDGFRVLAHLLADALAVVAPDPDALVAVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP02</accession>
    <name>A0A7K0JP02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="37079" checksum="AB45EF4244DEFF0E" modified="2021-04-07" version="1">MTDDWVAREEGGRSKYCCTINPSDAGTPDPPFTLTQLRYFVAAAEASSMTGAAQRLMVSQSAVSSATALLERQLGVQLLIRHHARGLSLTRAGERFAREARSLLAHASDVGDGARGLGEALAGGLTVGCFETLAPFYLPGLLGAFAAAHPQVEVDIIEGEAPLLRDALVQGRCESAVLYDLGLGGDLETELVAEAPPYLAVAADHRLAGSSGVHLAEVADEDMVLLDLPHSRDYFLGLVEHAGFAPRVRYRSTSYETVRALVAAGVGYTLLNQRPRTARTYDGGLVAAVPLLGDPQRLAVVLATAAGVRQTARNRAWAVVCRATLPELVRSFTDPHPICIDSVDVKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP91</accession>
    <name>A0A7K0JP91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000046">
        <property type="protein sequence ID" value="MST31364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="4">
        <location>
            <begin position="7"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="527" mass="57317" checksum="CD11C6A67C30BEDD" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP97</accession>
    <name>A0A7K0JP97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000132">
        <property type="protein sequence ID" value="MST31778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="13101" checksum="68D7B3433C7CD83B" modified="2021-04-07" version="1">MDAVELVVLGEADWTRAWLDATLRNGGFRVDWETPSTGTARRGDRIDGWLLGPRSRWLQLGLRLVPAAGGGEPGSPLTSIRIERVGPPNRPGRSWDAAVAEVADRVTAAFRGTDRLASSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC6</accession>
    <name>A0A7K0JPC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylo-alpha-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000061">
        <property type="protein sequence ID" value="MST31404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="29"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="630" mass="66240" checksum="45FA4966CF60BCA0" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF6</accession>
    <name>A0A7K0JPF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000152">
        <property type="protein sequence ID" value="MST31838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="234" mass="25354" checksum="DBD323B81E0F98D3" modified="2021-04-07" version="1">MDVREAMRTQHACRYYRPDPVPDDVLYDAFDDARFGPQGGNRQPVRFVVVKDPAKKKALGELYIVPWTAYSTAAKQGIEAIVAEADGTAKSTRLGGMRDPMKSLLDADHFAEHFGEHPVIIVVCADIANTHPTDTELGRLSIVGGGSVYPQAQNLCLALRARGVATTFTTLLCAFEPQVKELLGIPAEWATAAHIVAGYPANGFPTRLNRLPVEELVSVDTWGQPLARAETAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR4</accession>
    <name>A0A7K0JPR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000174">
        <property type="protein sequence ID" value="MST31913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="13065" checksum="9BB3A7F0DAA87170" modified="2021-04-07" version="1">MHEGGWRVEAVPDGGGGLSWRFYDRDGAPFPPPPAPPPDDLDLDDDVEPLACVPDYVGDPLDVVATTHVLLDLAGAFDPHPPDGAPLPDPPGGIEDDRCFAEPDSALTAGVSAERVSAERFRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX8</accession>
    <name>A0A7K0JPX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="347" mass="39343" checksum="29660C04048C779E" modified="2021-04-07" version="1">MSEIGRRYWRTRLRRWPTASHTPAPGYTLLLPVPGDLPVFLELALVASAAQRAEHRVRTIVIPDRMTPAVATLVEEHRPGWDGPLEIALLPRPERWFLPALHNGSRNHGMQLYSGVSASRTSHVILHDADLFPTRTDFFERQYALCEQRGLACLGVSGVWDPWYAEHGLKLAATWDMCASVDWLRSYPPRDHIGHDGRLFAEAHTFDTTLLPQALTDPTLVDHTDDPESFVHFNYVITCYRFFQQQGAAYCDDNFRLLFVAIVTHLLGVRQAHSSFPSVGQLAAGAHSGSGPMRYPQGQDAAEQYRRFRQKLERLLTSDWVRPGSPAQVEAELADFDTLYGYEREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ5</accession>
    <name>A0A7K0JPZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000191">
        <property type="protein sequence ID" value="MST31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15682" checksum="1ACAAFE6D4CD2957" modified="2021-04-07" version="1">MSGHPRFHLAVPVDDLDAARAFYGDLLGCPQGREADTWVDWDLYGHQLVTHLVPRAADRVAGRNPVDGHDVPVPHFGVLLGVEDFHLLAGRLRDAGVRFVIEPHLRFAGLPGEQWTMFFLDPAGNALEFKAFTDDAAVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ00</accession>
    <name>A0A7K0JQ00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">GHK86_04525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000191">
        <property type="protein sequence ID" value="MST31991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="545" mass="60232" checksum="D6CF4029533BFADF" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ67</accession>
    <name>A0A7K0JQ67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000210">
        <property type="protein sequence ID" value="MST32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="16565" checksum="ECC12B62C74BEB00" modified="2021-04-07" version="1" fragment="single">MEYTEVLRRRRMVRDYLDEPLPPGAADRVLAAALRAPSAGFSQGWGFLALESPDDRDRFWTHVPGAPEGMRRAPLVVVCCSHKDAYLDRYAEADKGWRDRAESRWPAPYWDIDTGMAALLMLLTAVVEGEQVDVRRGQPELHLRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG1</accession>
    <name>A0A7K0JQG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000235">
        <property type="protein sequence ID" value="MST32188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="21689" checksum="20294E6EA51923B6" modified="2021-04-07" version="1" fragment="single">MSPSPPLHVPRRPVRFVTAASLFDGHDAAINIMRRLLQRQGAEVVHLGHNRSVDEVVAAAVQEDADGVAISSYQGGHNEYFRYLVDRLRAAGRDDVRVFGGGGGVIVAEEIAALQDYGVARIFAPEDGQRLGLERMVNTMIEACDRPRPAPTDDEWDRLASWDAGALARVVTAVVDGTLGPERLAALRAAAAAAAPHVPVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH8</accession>
    <name>A0A7K0JQH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000231">
        <property type="protein sequence ID" value="MST32173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="54"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="545" mass="57637" checksum="5F2A5E0FB2404216" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX5</accession>
    <name>A0A7K0JQX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000266">
        <property type="protein sequence ID" value="MST32303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="85"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="36187" checksum="5650FFA890A2B43C" modified="2021-04-07" version="1">MTIKAEYIWIDGTQPTALLRSKTKILSSSGELPIWGFDGSSTNQAPGRASDCVLKPVFSCPDPIRGGANLLVLCEVLLTDMTPHPTNTRAPLVEVATKYANQEPLFGIEQEYTMFRGSRPLGFPDHTGYPAPQGPYYCGVGADDIYGRPLVEAHLDACIAAGLSLSGINAEVMPGQWEFQVGPLGPVECSDQLWVARWLLHRIGEDHGISVTLHPKPVRGDWNGAGCHTNFSTKAMRETYDAVIGAAEALGKNAAEHVANYGHGIEDRLTGQHETAPFDEFSYGVSDRGASVRIPWQVAQEGRGYIEDRRPNANMDPYVVTRLMVDTCCSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY4</accession>
    <name>A0A7K0JQY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_04595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000195">
        <property type="protein sequence ID" value="MST32004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="44418" checksum="8F338823E1BD1796" modified="2021-04-07" version="1">MSDHAVVADHVSKRFRLFKEKNNSLKATIMRGRRVVAEDFWAVKDVSFEVPKGEAFGLIGENGSGKSTMLKCLTRIYRPESGRIAINGKVSALLELGAGFHPELSGRENVFLNGAILGLSQKELRQRFDAIVDFAGIGKFIDEPVKNYSSGMYVRLGFSVAINVDPEVLLVDEVLAVGDEAFQRKCNEKFADLKADGKTIILVSHAMSAVQNMCDRVAWFEHGELKEVGDAREVIEHYTGSVQVERDVDESGRPHWGSGEGQITRAELIGAEGEVVERLVTGAPGRIRLHYEMREPVAQPVFSMYLSTINGQPVSGPNSRAYECVPDKLDGRGYVDLCMDEVRLLPGTYDLTPLITDITMMKVLDQRQNLLRFDVERGGLLREDWGVTTLSPRWEITPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA9</accession>
    <name>A0A7K0JRA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000302">
        <property type="protein sequence ID" value="MST32462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="20096" checksum="2CD3796B0113AC5E" modified="2021-04-07" version="1">PVPPLALARTGDELAGAARTALGAGASALCLKLEDPAVPHKSDVGGVLLGVGPDEVADAAGDLWRRFPGTPLLVMPMLRRGLELLAGAGTDPDFGPYITIGRGGVTAELDPDVALAPAPLTPARAHELWSSLRCAPLLAGWRGAPAVDLGALAGLAVALGDLAAAHPALTVECNPVIAYAEGFAIADLRAVGEGDRRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP1</accession>
    <name>A0A7K0JRP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_07770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="598" mass="63006" checksum="4DCF4EFF76F0DBC0" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR2</accession>
    <name>A0A7K0JRR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000340">
        <property type="protein sequence ID" value="MST32607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="273" mass="29351" checksum="19F38A8ED0886336" modified="2021-04-07" version="1" fragment="single">MAQVYLAQDTLLDRPVALKVLFPELSVDESFVQRFRREARAAANLTHPNIVSIYDWGQGSQTYFIVMEYVDGETLSARIRRGPMTPDQAAIVAIATAGALSFAHRRQVIHRDVKPGNVLIDRSGQVKVADFGIARAVGTAEDLTQAGAVMGTATYFSPEQAQGQPVDARSDVYSLGVVLYEMVAGRPPFHGDNPVAIAYKHVREEPPPLREVNPDVPAAFAAIVAKAMAKAPEDRYQTADALRVDLERHRAGQPLVGATAPAAGDATVVAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT1</accession>
    <name>A0A7K0JRT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000352">
        <property type="protein sequence ID" value="MST32658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="8433" checksum="65A92066EAE41E0B" modified="2021-04-07" version="1" fragment="single">MNPTNPFRPDGNPLGELRDIIGIAAGDLPDIPAPIHWPALPAEEAAEAWRDLRCWVEALQERFGLDHHVLPGCWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY0</accession>
    <name>A0A7K0JRY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2252 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000362">
        <property type="protein sequence ID" value="MST32690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="470" mass="51116" checksum="3827D02E7059185B" modified="2021-04-07" version="1">MTDVVQERPTGWLPPTERQQLGRAARREAPRQAIAAWEAAGSRADPVDILQAQATSRVPELVGIRYGRMLQSPFAFYRGAAAVMAADLAAGPSSGLEVQLCGDAHAANFGVFATPERAMVFDVNDFDETARGPWEWDLKRLVASLAVAGRERGLSAKQRRVVLLETCATYRRAMREFAGMGNLALWHLKLDATVIQRWQAQLSRGQIARTKGTIARARGKDHTRAVARLTEQRGGAIRLISAPPLVVPVRDLPGAEMLDVQATVQGLIDAYRDSLRPELHRLLGTYRVVDMARKVVGVGSVGTRAWVVLLVGRDERDGLVLQAKEAQASVLEPYVGASPFANHGERVVVGQRSMQAVSDVLLGWLRAHGLDGVERDFYVRQLWDGKGSADLATMAPNGLQVYGSMCGWTLARAHARTGDRVALAAFLGSSDAVDRALTRFAEGYADQNERDFRALEAAAGAGRVHADAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS17</accession>
    <name>A0A7K0JS17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000367">
        <property type="protein sequence ID" value="MST32713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="27281" checksum="2AFD72A016D4CD84" modified="2021-04-07" version="1">MSARFAGSGVIVTGAGQGIGQSVAEAFAAEGAEVLLVGRTPDTLEAEVGRIASQGGRAWALQADVSVPADVDAVVAAASRRWPRIDVLVNNAAVVHEAPFLEVSDDQWSEVVGIDLTGVFLMSQRVCRAMAGRGGGSVVHIASIDASGADGPYVAYNAAKAGLLGLNRTMAVELAELGIRVNAVSPGFTHTAMTESAVTPEIMDHLLHRFRRVPMRRLVRPAEVAAAVLFLASAEASAITGTNVIVDCGLTANLYILETLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS38</accession>
    <name>A0A7K0JS38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ORF">GHK86_08450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000379">
        <property type="protein sequence ID" value="MST32750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="622" mass="68171" checksum="ADD0B130F176F17A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS55</accession>
    <name>A0A7K0JS55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000381">
        <property type="protein sequence ID" value="MST32757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="273" mass="28514" checksum="014FA1C68B967485" modified="2021-04-07" version="1">MSTERHTSLISTARAFVRMGCQATLSYPMSLVLSQLGNGVAVVSLFFLTRIVRDGPDVGHNYLTFVVLGMVGQNLVMSAIFGIGTEMDAAIQQGRLEMLLIEPIRWPIIPAGLALWPMILSLWSSALTIGVGLALGVHLSLLGVVEAIPLAVVASVSGLAIGILAATVRILAKRSDPVFLIYSVLSGLVAGISVPINVLPAPLRALAWALPTMYVSTGLRKLLMANPAGVYGPGALWATLALAAAAVPLAALAIVLFNRSVNVGRKLGVLAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB5</accession>
    <name>A0A7K0JSB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000402">
        <property type="protein sequence ID" value="MST32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8301" checksum="F1EA6A267CF2F5CC" modified="2021-04-07" version="1">MREDGRRAAAEALHRLADGVEAGSIAFGGSEVACSDDFTLVVELRPRDAGQVRSALVHLTGWDEDSLALERELSHPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ6</accession>
    <name>A0A7K0JSJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000429">
        <property type="protein sequence ID" value="MST32912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="443" mass="44851" checksum="EA64DA3C68EB7678" modified="2021-04-07" version="1">MPAATGSTADGATVMELGDALAWLDRHEGRATVDGHRSASGRPSERMAALVDVLGHPEAAAPVIRVVGVHGKTATIGAIAALLTAKGLSVGTLTGPHLDRLNERLVVDGQAIADDELAKVLSDLADLDGLVPGPASSWRELLTAAALRWFSDRPVDVVVLEGGGLEDPAAVVDPAVLVVTDLEPGGSPPGGRADGSPVLALPAGVPVVLGDPDPGGGDALRRGLPPHPLWQVGRDYACTANHLAVGGRTLDIRTPGATYRGVWLGLHGRHQGDNFATALAAVEAFFGAPVEEPLVREAAAAVRAPGQLEAVAHRPTVVVDRACDLVAARLVGESVPEAFAAARSRILVVGLPEGAEAEPLLAALGAGSTRLVVACAPDAPHAQSSASIVRAAGALGLEVLERDTVREALDSALGAAHPDDLVLVVGPPAVVAATRAALGAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ9</accession>
    <name>A0A7K0JSJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000431">
        <property type="protein sequence ID" value="MST32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="33207" checksum="2902E35164369A09" modified="2021-04-07" version="1" fragment="single">MLPQGPEPPRLTPEPAARGSEALSGRGRGRHPRRRGWDRATVAGTTATGGDPMDVRAGTMRAALRHRPLRRLLAALAVSQAGDWLYNVGLLALVYERTHAAAWVTIATVARVLPMVVCGPFAGVLVDRYDRRRLMILSDVLRAGAMVVLFATAALGWPIVLAPLMAALATAAGSPYPSAVAVTVPRLVPEAALGSANGLRSTIGSACVVIGPALGGVLLVVGSPATAFAANAASFVASALLVAAVPDGDWRLPPAGAERSAVHPVSEARAGLAALRANPLALRLAGADATCSVVYGAQTVLLLLVSRSLGQGAAGYGWLLAGAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN1</accession>
    <name>A0A7K0JSN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000439">
        <property type="protein sequence ID" value="MST32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="5628" checksum="C43F8D58AB4FF1B8" modified="2021-04-07" version="1" fragment="single">MEARPERDGDALLAALAGWAADRRAAEAVAGRARERWLRQQAHETATWLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP0</accession>
    <name>A0A7K0JSP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="24968" checksum="A1932704F1243669" modified="2021-04-07" version="1">MTVHVEDVLTAVESRVDHLRASVGEPPEAEDGWRSCDAVTAADLEAAIDGAAAGNRQVAASLLVQSYAHRVAAVSLAAFAVGLPWPSPAAAATSVRLAGGRARALRFRTAALGEAGDIESLVDATFASHLVPFVSAVRAWERLGERLVWANIAASCAAAFRAVEGSARDRGDAGEQAAIRRRAAELLEHAPWLEGTGWFDADSTDWGWQRSACCLWYRTSGGRTCEGCSLRPKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR5</accession>
    <name>A0A7K0JSR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11597" checksum="97CC1F541F6B01E4" modified="2021-04-07" version="1">RALVAARAMGADPLVDAATALARRARLDVDADAPAPDPAVEDPLVPFGLTEREREVLELVALGRSNPEIAERLYISRKTVSVHVSNLVAKLGVSGRLEAAALAHRLGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ6</accession>
    <name>A0A7K0JSZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="29091" checksum="C1E4CEB97133D31E" modified="2021-04-07" version="1">MWLEVTMTGPDSDGWPRTVGPDWEWDWQSSEACVEAMEAASAGASEDLVLSVVARYAVENLVLNAVHEIGEWFRFDGRRVFPAHPDDAQVGDGKVSDDLDGNGRVHLEFGYPPAVPPARVAVSDPGHSLRDRVTGIVAAPRFTYLPGTSISYGRDGPAVAGPDGAAGVWRSAWSLAVRQGADAAVAADCAGGLIDAVATDVHRALVHYEADRVCRAFHVDGHRVWTLASADPGRRDPEELTDPPLQPLRIAIVHADRLLPGRGPGSPSRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT14</accession>
    <name>A0A7K0JT14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="61" mass="7000" checksum="7FB11E141B6A22A5" modified="2021-04-07" version="1">MTETEPRHCGRCQREFDGDPSLYFQTDWALCPTCREILLPRPAARQPLPALDDAGRDLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT53</accession>
    <name>A0A7K0JT53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-sensing transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000496">
        <property type="protein sequence ID" value="MST33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9470" checksum="89AD34141EAD46A4" modified="2021-04-07" version="1">MDLDAEALDGVVKRLRRAQGQIGGVIRMIEEGKDCADVLTQLAAASRAVNRAGFKLVATGLRDCMLHPDESTELSEDQLERLFLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT65</accession>
    <name>A0A7K0JT65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000493">
        <property type="protein sequence ID" value="MST33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AdoMet activation" evidence="4">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="32819" checksum="AE885AD4B2424510" modified="2021-04-07" version="1">AGEAAGAPRPRRAPSVRTDNPVFTPPWVGSRIERGVPLDDIAAYLNETALYRNQWGYRPRRDEGDPAFKERLRAELRARLALAREADVLRPAVAYGYFPVNSEGDELVVWKDESRSAEWLRFTFPRQPAEPWLSIADFFRPVDSGQEDYAAFHVVTMGPAVSEETARLFQSDRYTDYLHLHGLGVEMTEALAEYWHRRIREEWGFADEDGPTLAGLFRQQYRGGRYSWGYPACPDLEDNAKCAELVGAERIDVRVDESSSWQFHPEQTTAAIICHHPQAKYFVVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT95</accession>
    <name>A0A7K0JT95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="119"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="32801" checksum="055DB11F2F09A759" modified="2021-04-07" version="1">MTTITSTAVVVYAPGLVDPERLALAGFLGGYRGLTRDAYALDLRQFVAFCEKRHLGLFEVRRSDIETFGRELEARGRATATIARRLCTVTGFYRYAEEEGLIAHSPAVHVRRPRIDYESHAIGLDRNEVGALLVAAGLGPASEHALVSLLALNGLRVSEAIGADIEALGVERGHRTLTVLRKGGKTVTVPLAPRTARAVDLAVGERCAGPIFTATHGGRLDRHGAARIVRRVARRAGIAKPIGPHTLRHAFITAALDAGVPLRDVQEAASHADPRTTMRYDRARVSLDRHATYIVATYIAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA2</accession>
    <name>A0A7K0JTA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_10670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000509">
        <property type="protein sequence ID" value="MST33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="11">
        <location>
            <begin position="6"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="12">
        <location>
            <begin position="314"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="477" mass="51453" checksum="2E6988FB4D8E80DE" modified="2021-04-07" version="1" fragment="single">MAQFMRESDALSWYLEGDPVLRSTVVAVAWLDRGPVWETFAGKVEQATRFLPAFRQRVVELPARLTGPRWAVDPEFDLAWHLHRMDAPAPHGPEVVLELARREAMTGFDRSRPLWQFTLVEHLEGERAALVMKLHHSLTDGVGAMQLAVRLFDDRRAPGRGAIAPPAPEGESPAPVGLVAEQLRWRWTRATRVAGSQLRAAAPAAVATARRPGRSARAALDTARSIGRTVAPVRATLSPLMTARGRGRYLDVIEVGLEELKDAAAAAGGSVNDGFLAAVTGGLRRYHEQRGAVVEHLRVMMPISIRRPEDPIGGNRITLMRFTVPVGEPDPRLRIAAIERRCRIARDERSLAYTNAIAGALILLPPAAVGSLFKRVDFVASDVPGFTAPVYLAGAEVERYVAFGPTTGTAFNVTLLSYRGRCNTGVTIDTAAVADPDALVGCLRAGFDEVLALGSGRRAVRAAVATPRAPAGPGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB0</accession>
    <name>A0A7K0JTB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000510">
        <property type="protein sequence ID" value="MST33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="32098" checksum="79E26526D3B3CE9A" modified="2021-04-07" version="1">MRAVRFHRYGGIDVLQIEDVPLRPLGPRDVVVRVRAAGINPGEAKIRTGALHDIFPATFPSGQGSDLAGTITETGSEVTLRQPGDDVLGWSWERSSHAEYVVVPQDQLVAKPADLPWPPAGALYVAGATAWASVNAVDPHPGDHVLLAGATGGVGTIALQLLRLRGADVTAIASPRHQAWIEQHGATFAAYGPRLADDLEHSTGRPPPDAVVDLHGGYVDLALSLGVAPDRINTINYDAAAAHGTRSDASAEGTQPDALAELARLAANHTIEIPIAATYPLDQVRAAFTHLEQRHPLGKIVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ4</accession>
    <name>A0A7K0JTJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">GHK86_09310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000429">
        <property type="protein sequence ID" value="MST32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="22850" checksum="3B9471CEDC97560C" modified="2021-04-07" version="1">MNPRAQYHVPGIFEQTNRGERGYDLFSRMLEENIIFLGTPIDDYVANAVCAQLLYLEYKNADKDISIYINSPGGEITALFAIYDTMKFVKNDISTFCYGQAASAAAVILAGGTHGKRFALPHARILIHQPYGGAAGQAADIEIQAKEILRMRDLLNQMLANDSGQTVEKVAADTDRDFIMSAGEAQQYGLIDEVITARELAGVPQAAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU10</accession>
    <name>A0A7K0JU10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000580">
        <property type="protein sequence ID" value="MST33403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="10712" checksum="4F5CEA8334567F0D" modified="2021-04-07" version="1" fragment="single">MHSTEQHGPVESRLAEVLRLAADGRFPPADGKVERLPSPKDPVGAVLAFTGHHLVAADVDRRWLSSALPAGDLSAPVAASFLVALSRHIAAHPRSLDVVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU48</accession>
    <name>A0A7K0JU48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_12145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="WJHE01000605">
        <property type="protein sequence ID" value="MST33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="422"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="518"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="836"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="879" mass="95011" checksum="8C794B51C5A35D4A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU64</accession>
    <name>A0A7K0JU64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proB</name>
        <name evidence="10" type="ORF">GHK86_12210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000610">
        <property type="protein sequence ID" value="MST33480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="281"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="214"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="369" mass="37942" checksum="AB145E5BBA874871" modified="2021-04-07" version="1">MTPVAPSLVVVKVGTSSLTDERGAIEPGAVAKLAAEVAGLRTDGTRVVVVTSGAIAAGLPHLGLADRRPSDVAVLQAVSAVGQGHLVLEWYRALDAVGLVGGQVLLAPHDFMDRSQYLHARQTLRLLLELGVVPVVNENDAIADDEIRFGDNDRLAALVAHLVAADLLVLLTDAPGLLTADPRFDSEASLIEEVAEVDHELESLAGGAGSDRGSGGMASKLAAAKIAAWSGVRAVIADAGRPGVLADAAADVAGVGTVVRPRARRLAARKLWIAFAVAARGTVVVDEGARRALTTRGVSLLPAGVVTVHGSFVADDAVALAGPDGKVFAKGLARHDAGRLRALAGRRSSELPAEVPPEVVHRDDLVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU66</accession>
    <name>A0A7K0JU66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Obg family GTPase CgtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cgtA</name>
        <name evidence="2" type="ORF">GHK86_12215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000610">
        <property type="protein sequence ID" value="MST33481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCT" evidence="1">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="13212" checksum="F66D53B6D2192C8A" modified="2021-04-07" version="1">PPGEAELCISAVTGEGIDALVRRLATMVADARASQPRPVRSVVHRPVPPGVVVERDTDGAWVVRGRPALRAVALSDLTDVQALEYAQAKLRGLGVDRALARAGARDGDRVRIGDFEFDYQPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU85</accession>
    <name>A0A7K0JU85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_12350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000618">
        <property type="protein sequence ID" value="MST33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="33"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="29310" checksum="9F34BB70B4862647" modified="2021-04-07" version="1">MTATTTGPTLTAPARPSAGRGSRLRWGVTDGLTVAKRNLIAYSRTPALLVFAVIQPVMFVLLFRYVFGGAIHVPVPGGYVSYLTPGIIGQSAAFASFGTAVGLAREIQKGVVDRYRSMPMARSAVLVGRLIADTLRMILTVLVLLGVSAAVGFRFHNGFWPAVGMIALAVAFGVTICAVSAYIGFAIRDEESVASFGLIWLFPLTFVSSAFVPVQSMPGWLQAFANNQPVTIVIDEMRALALGGPLVLHGWQSAVWLGGILAVFLPLAVRAYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA1</accession>
    <name>A0A7K0JUA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_12420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000624">
        <property type="protein sequence ID" value="MST33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="LUD_dom" evidence="7">
        <location>
            <begin position="85"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="321"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="437" mass="46556" checksum="87E5A512ED85A98F" modified="2021-04-07" version="1" fragment="single">MNDAGWVPVAPPGVGHLRGGRPFPQEAADALADATLRSNLTGATTRIRAKRDAAVAEVPDWEQLRAAGAAIKDDVLAHLDTYLLQLEEQVTARGGTVHWAADAVEANRIVVDLVRAAGADEVVKVKSMATQEIGLNEALAAAGVAPIETDLAELIVQLGDDWPSHFLVPAIHRNRTEIRDIFRRAMPGADPDLPDEPAALAEASRRYLRARFLAADVAISGANFAVAETGTLAVVESEGNGRMCLTLPRTLVTVMGIEKLLPRWTDLEVFMQLLPRSSTAERMNPYTSFWSGATEGQDFHLVLLDNGRTATLADHAGRAALRCIRCSACLNVCPVYERVGGHAYGSVYPGPIGAVLSPQLTGIGSNATLPFASTLCGACYQACPVAIDIPTMLVHLRERAVAAGAEPIAERAAMRVMAWLMTSPRRWGAGLAALRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB2</accession>
    <name>A0A7K0JUB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">valS</name>
        <name evidence="12" type="ORF">GHK86_12330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000617">
        <property type="protein sequence ID" value="MST33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="128"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="660"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="754" mass="84428" checksum="1F257C5A4FD0DB76" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF2</accession>
    <name>A0A7K0JUF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="27264" checksum="633E3381767B95BF" modified="2021-04-07" version="1" fragment="single">MTGADTETATGAETATGGRGVLRPGERVLLFDAKGRRYLVTLAPGAEFHTHAGPVPHDEILGGEEGRVVRSARGARYTVVRPTLSDVVLKMPRGAQVIYPKDLGPLLILADVFPGSRVLESGLGSGALSMALLRAGADITGYEIREDFAARARANVAGFLGEEALERYHVSVRDVYEGIDTSGLDRIVLDLPEPWRVVGHAERALRPGGILVAYLPTILQVAALRERLARSAFGLAETVEVLQRGWHVEGQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ5</accession>
    <name>A0A7K0JUQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000678">
        <property type="protein sequence ID" value="MST33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="11266" checksum="ECA681EE027927F5" modified="2021-04-07" version="1" fragment="single">MWTINEVAVAGRLSRPAEQRVLPSGGSVVSLEVTVPRVVGPSETVPVSWADAPAWSATLDVGQEILVVGRVRRRFFRAGGATQSRTEVVAHRVLRLPAGRRARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR9</accession>
    <name>A0A7K0JUR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000692">
        <property type="protein sequence ID" value="MST33692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="3">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="3">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="23594" checksum="1666BF45C1A0674A" modified="2021-04-07" version="1">MGELRARQDERLEVIEASVIQLFALVAEGLVASTEALLSGEQELLDVLAERERSIGDLYRDIERLVDGQLGDGRPAPGDLRFMLSVLRVVPELERSHDLVVHIARRAGGGFDAELSPRCRGLIERMGRLGSDMWRQAADSWYERDATAAAALVERDDEMDALHAALSAEIASGRLALPVAMDMTLVARFYERLGDHAVNVARRVVHLAATAAAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW0</accession>
    <name>A0A7K0JUW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_13420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000697">
        <property type="protein sequence ID" value="MST33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="23946" checksum="180E58C63AEE3D93" modified="2021-04-07" version="1">MSDPGRKAALYEAIAATGRALANGKRLELLDLLAQGERSVDSLARAAGLGLTTASAHLQALKRSGLVVTRRDGTRVHYRLAGDDVAALYHRLLEVARTHQPVAEQARRAYLGPDDTAELTRHELLERVKAGLATVVDVRPAEEYDAGHIPGARSIPLGELEARLAELPDDAEVVAYCRGTNCVLAHTAVRLLNGRGRRAVRLTEGMLEWRLAELPVAAGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ5</accession>
    <name>A0A7K0JUZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="16044" checksum="445AA4AF21DF64D7" modified="2021-04-07" version="1">MPLDGEYQPSTQQWVRDQVELYESSGGKEGTTLRGLPVIVLTSVGARSGKIRKTPLMRVEHAGTYAAVASQGGAPTHPLWYHNLKAHPRVELQDGPHKGDYVAREVTGGERDTWWARAVSAYPDYADYQRKTDRQIPVFVIEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV93</accession>
    <name>A0A7K0JV93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_14275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000759">
        <property type="protein sequence ID" value="MST33880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="331"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="541" mass="55743" checksum="347624AF2E51A378" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV95</accession>
    <name>A0A7K0JV95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000751">
        <property type="protein sequence ID" value="MST33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="350" mass="36985" checksum="35E1F0854BB2A1DE" modified="2021-04-07" version="1" fragment="single">MRGMQPDDIALIAAAGEVALSPDGRRAVYTLTTQDLEANQARSRLWIADVDGGRPRPLSAGPHDHLPRWSPDGGTLAWVASEDGTTTIRTLAAEGPGTPSVVCSWPDEITELAWSPSGDRLAFVGRVRDVARYGEPGSPKAVAEMPPRRVTRLLARFDGDGWVFDRPTHVHVVPVDGSARPLALTSGDAPASDIGWSPDGDRLVYVAAGHRDWDLDGRNDLWLVAADGSAPGIRLTGTTVAWSHPSWSPDGARLAALVDPTPVNGPRHGQLWVVPVDDPVPVRWAAGYDRNLAPHGAARAPIWAGEELLVAVEDEGRLGVVAVGAPSGGSAGEVRPVVGGERVVHAFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF9</accession>
    <name>A0A7K0JVF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA(Ile)-lysidine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="27706" checksum="B9F1177A33A0EC5D" modified="2021-04-07" version="1">MLEPGDRVLVAVSGGKDSLALWDLLLDLGYDADGLYLGLGIEDYSASSGGYARAFAERRGAHLRVVDLPADLGFDIPTGARAAKRAPCSACGLSKRHLFNAAALEGGYAAVATGHNLDDEVAVLYGNVLRWDLAYLGRQQPVLPGGDGFARKVKPLVRLGERETAAYCVLRGIDYVVEECPMAAGNRHLRYKEAMNTIEERSPGTKAAFYFGFLDRVAPLVEATAAEEREDLHPCPSCGSPTVAEVCAFCRLAERARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP8</accession>
    <name>A0A7K0JVP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisA</name>
        <name evidence="11" type="ORF">GHK86_14990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="WJHE01000814">
        <property type="protein sequence ID" value="MST34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="25238" checksum="98B5D6789B5855D8" modified="2021-04-07" version="1">MDLFAAVDLRAGRAVRLVEGDFGRETAYTDDPVGVARRFAEGGAPWIHVVDLDAARTGEPTNRAVIEAIVAAVTVPVQVGGGVRRVEDAAALFAVGVTRVVVGTAAVSDPEVVGAIAGRWPGRVAVGLDHRDGEVQVRGWTEGGGRRVAELIPEVLDAGASAVIVTDIRRDGRLAGPDVVGLAGLLETTGAPLVASGGIAGSDDLRLLASVRSGGQGLAGAIVGRALYEGQLTVEEAVAACGAMDPGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT0</accession>
    <name>A0A7K0JVT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ORF">GHK86_13040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="WJHE01000670">
        <property type="protein sequence ID" value="MST33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="152"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="374"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="510" mass="54521" checksum="A83D3CC39949CD72" modified="2021-04-07" version="1">MAELTINAADIAEALRRNVADYRPGVAREQVGRIITVGDGIARVSGLADAAVNELLEFESGAVGLALNLDEESIGAVVLGSVDDIDEGQAVRATGRILSVPVGDGLLGRVVNPLGEPIDGRGPIEAGEERRLEVQAPGITARQPVGEPLQTGIKAIDAMTPIGRGQRELIIGDRKTGKTTVAIDTIINQRGQGVKCIYVAIGQKGSTVAQTVDILREYGALEYTVVVSAPASEPAPFKYLAPYAGCAMGQHWMDNGEAALIVYDDLSKQAEAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDERGGGSLTALPIIETKAGDISAYIPTNVISITDGQVFLEADLFYAGIRPAINVGNSVSRVGGAAQIKAMKSVAGTLKLDLAQFRDLESFATFGSELDKVSQAQLDRGYRLTELLKQPQNQPVPVEEQVVAIYAGTHGFLDDIPVSDVRRFEQELLQYLKGEQPQLLETVRTTKALPDADALDAAIKAFKGVFAVTPERAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ0</accession>
    <name>A0A7K0JVZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000855">
        <property type="protein sequence ID" value="MST34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029660819" evidence="2">
        <location>
            <begin position="26"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="27780" checksum="845A36A064EC8A1E" modified="2021-04-07" version="1" fragment="single">MVFVFGLVSAVLLAVGFVVQQHVAALTPADERLSPRLLLDLIGRPLWLVGIASMAAGQIVEAVALHFGDLTVVEALTATNVLFALPMAAAWRRKRLCRRDWVGAAGIVAGLATFVIAADPPATRIPVVPFGSWLAAGLAILAAAAVVVAVGRRRSAAPQATLFGLGAGIVFGLQDGLTQRVLQVPFGIHFLTSWVPYALLAVGITGLLIAQSAYQAAPLKASLPAINIAEPVTGIGLGAGLFAQGLWVGTEPLIFELLGIVCMMIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW02</accession>
    <name>A0A7K0JW02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000861">
        <property type="protein sequence ID" value="MST34127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="17168" checksum="E2CD6AEE51F5E6EF" modified="2021-04-07" version="1">MHQLLVRSPSPLLLRGVVHGALKVHLDRFLNVPAARLPVATTGDLADLAACLDAEGGVDEAGAVVYGFLRGGGRRDDVVAVLGHGLLREDAGFHWFQMFEAAVRQAGAWPEGSEEAALILTGAARFLAAHTPTRRELAQVVRIAGRLRRGEALYEDGGEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW06</accession>
    <name>A0A7K0JW06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000865">
        <property type="protein sequence ID" value="MST34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="11731" checksum="24C27873166C98CF" modified="2021-04-07" version="1">AAFAGRASTLVARAGGDPEAVRGEHVTAAAAAGEPEAEAILAELAWWLALGLANLANALDPEVMVVGGGLVDAGEVLMRPAREAFSRLVEAGGQRQVRIAPAALGARAGAVGAGLLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW18</accession>
    <name>A0A7K0JW18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000867">
        <property type="protein sequence ID" value="MST34141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="32443" checksum="A1697DAA91E4512A" modified="2021-04-07" version="1">MTTTSRRVPTAPFGRTGHTSSRVIFGAAALSTLTDDEAAPLLGLLDEFGVNHLDTAASYGDSELRLAPWLAGRREDFFLATKTGERTGPAARAELERSLGRLGVDHVDLVQLHNLVEEDEWETVHGPGGALEALLAARDEGLTRFVGVTGHGLRIAGMHRRSLARHDYDSVLLPYNWVLLRDPAYRADVEALLETCAERDVAVQTIKSAARRRWRDAGGDHLSWYEPIHEPTALARSVRWVLADPQRFLNSSSEPTLLRTILEAAAGGGGAPSDAELAADAESLGVEPLFDGDRLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ4</accession>
    <name>A0A7K0JWJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000944">
        <property type="protein sequence ID" value="MST34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15235" checksum="CF383F7D954C306D" modified="2021-04-07" version="1">MLGTIPGTLVARARRQQLMLTIQQDQTPEGYTICRPVGELDAFTVSQFRQALAEMASSKRLLIDMSGVPFVDSAGLGALIGGIRRARELGGDVAVSCNRPSLVRLLRTTGFDRIVTVTETVDEAIAALDARSSESDGAGEPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX21</accession>
    <name>A0A7K0JX21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001039">
        <property type="protein sequence ID" value="MST34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="36844" checksum="6BFBE15D5647D698" modified="2021-04-07" version="1">MAPAPEAVAVEAAGREVRVTNPDKVFFPERGETKLDLVRYYLAVEGPLMASCADHPVMLQRYPEGAGGPSFFQKRVPASRPAWLQTTVVSTPNGTPSEALVAADVAHLVWAVNLGCLGFHVWPTLAADPDHAVELRIDLDPSPGVSWAMVREAAGEVRRLLDELGTPGLPKTTGNRGIHVYVRLEPRWGSIEVRAAAVAVARELERRRPDLCTASWWKEERGARVFVDFNQNAPHKTVFGAWSVRGHVGAQVSTPFAWEELEAIDPGRCTLATVPDRVAAGGDPWAPLYEHPRSLEPLLELSAADRAAGLPDAPWPPVYPKMPGEPPRVAPSRARKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX46</accession>
    <name>A0A7K0JX46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_17570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmB/CycW/HelB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001052">
        <property type="protein sequence ID" value="MST34523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003544">
        <property type="entry name" value="Cyt_c_biogenesis_CcmB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03379">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="26548" checksum="6F8CA70C8FE4C416" modified="2021-04-07" version="1">MPPRLQCRPRRGTPHRRGPRWSPTRRPPVWRDALLVAGKDLRVEARSRVTTNQVAPYALVVLLLFGFAFNQDRYVLTHVGPGLFWIAVLLCALLAVQRSFSLESADGARDGLRLSGLDGGGIFLGKAMAIAAQLAVLEVILALGVVVLFGTRMANPLLLVVTCALATAGLAAAGTVYGVMAAGLRVRETLLPLLLLPVLAPVLLGATQAWLAAIGLAIGSGWRWLTLLGAFAAIYLTLGVLAFGTLLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX82</accession>
    <name>A0A7K0JX82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR02678 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001071">
        <property type="protein sequence ID" value="MST34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013494">
        <property type="entry name" value="CHP02678"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09661">
        <property type="entry name" value="DUF2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02678">
        <property type="entry name" value="TIGR02678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="366" mass="40013" checksum="B7A8D16DF420BFED" modified="2021-04-07" version="1">MNDAARHLLRTPVVMAAVEPDLHREVRRHEEELARFFRGYLGYRLQTDARMARLYKAGLGPGTGRPFLRRDRSTFTPRDYTYLVLVCAVLLSTRSQVLLSAVASEVRQAAAEAGVELGGDTLTERRALVHALRKLLEWGALTEDAGSVADYAEDPSKEALLWVERDLIRSLVAVPLREIDDPAELVRRASEIDPESVRHAVRRKIVEQPVVMLADLSAAEAAWLRQNQRREAQILEDNLGLRLEIRAEGVAAFDPLDELSDVRFPREGTLGQAALLAVAALAEALAPAGPAGDVPVPAGMLEAVVGGLLAEHAARWSKDYTEAPARLVADVRDLLVAMGLAGEAGDASLLLRAVAARYAPQPEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE2</accession>
    <name>A0A7K0JXE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001108">
        <property type="protein sequence ID" value="MST34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045220">
        <property type="entry name" value="FRHB/FDHB/HCAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31332">
        <property type="entry name" value="PTHR31332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="392" mass="42602" checksum="CF4D1584DED1752C" modified="2021-04-07" version="1">MTTAPPEAPAKPARERWRAHWTELFDEVVTTGLCTGCAGCVISCPHDVLGYDTSNGVYRPFHLEEEGGPGGCGHGDRGCTSCTRACPRFRQWEPEIDTYLHGRERLPEEQAGITGDIFLARATDPELHQRGQDGGLVSAILAWCLEHDRIDAALVSYLEGDGRSWRAVPGVARTRAEVLAASGSRYTYSANTLAYADAVGQGAERLAVVGMSCQASVPAVMRARKAGKPGRRLALSIGLLCSKTFDDAIFPELFEARYGLRREDIVKMNIKGVFQIWMRDGSYHEVPLKECHAWTREGCKSCPDFAAEHADISTGGIGAFNDWTLTIVRTDAGRELMAAMVADGAVETRPGDDDPGAIALLRKLSTVSRRRWPEQAVAAPRLGVPPPKPKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI6</accession>
    <name>A0A7K0JXI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">prfA</name>
        <name evidence="7" type="ORF">GHK86_18305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001137">
        <property type="protein sequence ID" value="MST34668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="354" mass="39300" checksum="261A6EA40EF261B1" modified="2021-04-07" version="1">MLDRLPGLEREYELVLAQLADPDVIADRARFRDASRRHRELEPVVLAARERRRVEGDLGAAKEMLGEADGAERAELRRELETAEGRLAEIDEELRVLLLPRDPNDGRNVIVEIRGAEGGEEGNLWARDLHDMYLRFAERSGLGVEPLGSDPSGMGGYNEVSFLVKGERAWTLLKFEGGTHRVQRVPVTESQGRVHTSTATVTVLPEAEEVDVQLEEKDLKVDVYRSTGPGGQSVNTTDSAVRITHLPTGMVVAMQDEKSQIQNRAKALAVLRARILKAEQDRQAAEASQARKSQVGAGGRADKIRTYNYKENRVTDHRIGLTLYKLDKVLAGELDELVDGLLADERARQLAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ1</accession>
    <name>A0A7K0JXJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001135">
        <property type="protein sequence ID" value="MST34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="23999" checksum="644F3B7460237468" modified="2021-04-07" version="1">MLFGDSHAAMWYPAVDRYARAHHERLYVWTKAACPPVDISLFSPDLGRTDTECAAWRAGVVARIAALRPTMVILGIAPNYDAAYGVVQDGPAWNRGLQRVIRAVEASGATPVVMGSIPSPPNDIPVCLSAHPDAVAHCDFPRIGHRIPGGGLDGNDQPGLEAEARAVAAAGGHDIDVESWFCGASSCPVVVDNLLVYRDNSHITVPWATYLAPLVDDELALAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU3</accession>
    <name>A0A7K0JXU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase/phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001211">
        <property type="protein sequence ID" value="MST34781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="260"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="374"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="456" mass="48313" checksum="CA018B4F7D361624" modified="2021-04-07" version="1">MARLDEIFKAYDIRGTVPDQVDAELARAVGGAFARFAGAPSIVVGRDMRPSGVELVQAFAAGATEAGADVVLLGLTSTDELYYASGALDSPGAMFTASHNPARYNGIKLCLAGARPVGAESGLAEIRADVESQLGGARPQAADRSGVLGERDVLADYAAKVRSFVDRDRLRPLKVVADTANGMGGLVVPAVFAELPFELEILFPELDGTFPNHPADPIQPANLAALRQRVVETGADVGLAFDGDADRCFLVDDRGEPVSGSTTTAIVARAMLDKHPGSTILYNLICSKAVPEIIAEHGGTPVRTRVGHSYIKAVMAETGAVFGGEHSGHYYFADNYRADSGCIAAVVVLEMLSVADRPLSELRAEFERYADSGEINTEVADPPAVIEAVATRYDPATHPGASLDRTDGLTVDLGTWWFNLRPSNTEPLLRLNVEAADAPACEAHVEEITNLLRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV9</accession>
    <name>A0A7K0JXV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsB</name>
        <name evidence="6" type="ORF">GHK86_18980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001220">
        <property type="protein sequence ID" value="MST34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="25141" checksum="E4879755EEF2D68A" modified="2021-04-07" version="1" fragment="single">RRWNPKMRRFIFGERNGIYIIDLQQTLERIDVAYSFVRDLVADDGVILFVGTKKQTQDPIATFAARCGMPYINERWLGGMLTNFNTIAGRVKKMQEYQRMRAAGDFEAMPKKEALILSRELDKLERNLGGIRTMNRLPDAVFIIDTKKEHIAVTEANKLGLPVVAVVDTNCDPDVVQYVIPGNDDAIRAGTLMCRVIADAVAEGRYIAASRAARNAPQGQAAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ0</accession>
    <name>A0A7K0JXZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001245">
        <property type="protein sequence ID" value="MST34835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="25754" checksum="063825AA18300C57" modified="2021-04-07" version="1">MSADGKSVGEGAATEVVTLAAYGRVVGLEVPGEAADRVTSRLPPGYTVVSSSADPDRRWSLGPGGDVERLWSEVELWVADQAEGRVFVHAGCVALRGRAILLPGRTMTGKSTLTAALVGAGASYFSDEYALLDAEGRVWPYPRDLSVREEGIGRRYPIGHFGGVTGQGPATVALVASVRFEPGAAWDVESTSAADGVLALLDNTVSARSHPAEALTATAAVARSASFLWGRRGDAAYAAGQLLALVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD3</accession>
    <name>A0A7K0JYD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001057">
        <property type="protein sequence ID" value="MST34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="167" mass="18138" checksum="A44E6BC60A73FF3C" modified="2021-04-07" version="1">MRTVNPRFFEDPMPFWEVEPGGFRDVVATNLTGYFLVARAFVPAMVRRGEGRVVNVSMNHETMRRRGFVPYGPSRAGAESLGAIMTEDLRDRGVTVNLLLPGGATATGMIPDGLPDDARARLLPAEIMGPPIVWLASPEAAGVTGERIVATDFERWRAARAGSPRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE8</accession>
    <name>A0A7K0JYE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_17755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="21802" checksum="EF870CE2DCDF1D0F" modified="2021-04-07" version="1">MAEQETFADQAMPYMGSLYTAALRMTRNPSDAEDLVQETYLKAYRAFGGFQEGTNLKAWLYKILTNTFINSYRSRKRRPEQTELDEVEDLYLYRRLGGLEAVSASRSAEEEVLEHFTDGDVKAAVESLPEQFRMAVLLADVEGFSYKEIAEILDVPIGTVMSRLHRGRKALQKALHDLGVRRGLVETSVDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF0</accession>
    <name>A0A7K0JYF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_19920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001341">
        <property type="protein sequence ID" value="MST34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="22561" checksum="80B7B0B7416190CE" modified="2021-04-07" version="1">APSTRSRRRRRAERPGPDLAPLVDAARSGDREALDELVAATYPDAYTLAYRLTGNEEDARDVVQEAYLRAQRGLGRFRGDAQFTTWLYRITANCASTLLLKRRRAATVPLTEELAVVDLRPERDPEWRATSQAEREAVAASLAGLPPRLRKVIVLRDIYDLPHQAIADQLGISEAAAKVRLHRARRRLKESLADRGKSGEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI5</accession>
    <name>A0A7K0JYI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001317">
        <property type="protein sequence ID" value="MST34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029704261" evidence="2">
        <location>
            <begin position="43"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="814" mass="82831" checksum="7F3C56AC5B1B056D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN9</accession>
    <name>A0A7K0JYN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001131">
        <property type="protein sequence ID" value="MST34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="180" mass="19430" checksum="E8EBAB909B05C629" modified="2021-04-07" version="1" fragment="single">ERGLATPLEDIAAAAGVGIGTLYRRFPTRADLVEALFQDRLAAYVADLEAAVGTEDGWAGLVWFLGRAAARQIADRALSELIEQDLGPDTIRQLRDRVLPLAERLVERARASGRLRADFTVGDLALVQHMLAGAGAVTSPVSPTGWRRYLTLLLDGMLARREAPTPAEEPAPTVAQLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP0</accession>
    <name>A0A7K0JYP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_20375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001409">
        <property type="protein sequence ID" value="MST35073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16706" checksum="E2EAC874E6E0A572" modified="2021-04-07" version="1" fragment="single">MTGWRRRTALAAAAVMADRLVGDPADRLHPVAWFGRAMTRREQRAWSDRRLSGLRHLGAGITAAAVPVALLGTAARRLGGAAADAALFIAVVATTLGARSLDVRAAEVGEALAAGRIDEARRMLPALVGRNPADLDEAEIARAVVESVAENTVDAVVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR1</accession>
    <name>A0A7K0JYR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001367">
        <property type="protein sequence ID" value="MST35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="126"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="19912" checksum="BCEFFFC596319069" modified="2021-04-07" version="1" fragment="single">APRVHEGVGAPPEVAVLRSGTLHVNRLGARSSLRAALLERLGTGGVLAPLLAGTTLVGSVGVGHPIGRRTFADQDLRLLDVLARHLGSALDHRRLERRLRHDSAHDGLTGLPNRTRFAELLDGLPDPSAVLLIDLDHFREVNDTLGHAHGDRLLRQAARRLATEVGRAGIVARLGGDEFAVLAPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR7</accession>
    <name>A0A7K0JYR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001147">
        <property type="protein sequence ID" value="MST34684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="32895" checksum="2F7C76D4B249221A" modified="2021-04-07" version="1">AAGGRAFASGLAAEDAVLHLLAPGDHLIVPDDAYGGTYRLVDRVWGRLGITHTPVALGDLDAVAAAWRPETRMVWAETPTNPRLGIVDIAGLASLAHERGGRLVVDNTFATPWLQQPLTLGADIVVHSSTKYLGGHSDVVGGLVAANDAEVLEHLWFVQNSVGAVPSPWDCFLTLRGIKTLAVRMDRHCATAATVAAALAGHPGVSQVLWPGLPDHPGHELAARQMRGFGGMVSFVVRGGEQTALAVAAGTRLWTLAESLGAVESLIEHPHRMTHASVAGSALEVPAGLIRLSVGLETPDDLVDDLLGALERAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS5</accession>
    <name>A0A7K0JYS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched chain amino acid aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001432">
        <property type="protein sequence ID" value="MST35103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="7681" checksum="D8A098521463B4C5" modified="2021-04-07" version="1" fragment="single">SYFPRGVAPVTVWLSTDYARAAPGGTGAAKCGGNYGGSLIAQAQAEEHGCDQVVWLDAIEHRLVEELGGMNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY9</accession>
    <name>A0A7K0JYY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001476">
        <property type="protein sequence ID" value="MST35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14896" checksum="B66A1FF2CE74BF7B" modified="2021-04-07" version="1">MRLRDFMQAPVYSCSPTASLSTAAREMETHNVGSLIVSGDADTIVGIITDRNLALALGRGLGPDATVSEVMSRHVVTISVDASLDDAAAEMDSHGIRRLPVIDEQRRAIGIICLDDLYNYLTQETITLAGAVRAQGAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ2</accession>
    <name>A0A7K0JYZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001497">
        <property type="protein sequence ID" value="MST35181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="372" mass="40669" checksum="28EC03EA334099D2" modified="2021-04-07" version="1">MMPCVASRAHAWLGRAAAAREALGGRVPESRVPLGLTCGGTLAALALVEGRLREALEIARQAVCQARMRGYDATIGVLDGRLVAARVLLERDDLRGAAQELDEAEVLCSQGGHRRWAAVVRAERARLAMEERRFEDALGYLDEARRPEVCGAASWFVDRRLDEIEVRCRLLMGDPTGAARIFDAAPPEWRSCELTARLRLASGRPDLAMNVLNGCRREAAPTAVAIERAVLRARCHAVTGNRRAAEQALQEAVDLARNERFTRVFRDEPALVTEILRGVVAGAPESHLGSLERPATAAAPSRGRAGVVLEPLTKRERELLDFLPSHLSQYEIARKMYLSANTVKTHMKGLYRKLGATSRSEAVDAARSCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ27</accession>
    <name>A0A7K0JZ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001510">
        <property type="protein sequence ID" value="MST35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13274" checksum="518F6DC8D803D5B0" modified="2021-04-07" version="1" fragment="single">MGEAAVALQGVEKWFGHVHAVAGIDLEIAPGEVVAFLGPNGAGKTTTIDLILGLQAPSAGSARVFGLDPRQAVRRGLVAAVMQNGGLLRDLTVAEIVEYTAHLFSTTRPVDEVMRRAGITDIAGRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ86</accession>
    <name>A0A7K0JZ86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001566">
        <property type="protein sequence ID" value="MST35266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="215" mass="23570" checksum="A98318D94291B766" modified="2021-04-07" version="1">MADPKADLHRYLQQGREAVVAKLDGLGEYDARRPLVPTGTNLLGLVKHLAAVELGYLGDTFGRPGELAQLWADLDTDPLADMWVPAEESREEVLALYHLAWEHGDATIAALPLDAPGRVPWWPEERAAVTLHQVLVHLVAETHRHAGHADLVRELIDGAAGRRPGDPSFPDQDATRWRAHYLRVEEAARRAGGEEEAAAEREGVSGEGEPTVMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD2</accession>
    <name>A0A7K0JZD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_21620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001615">
        <property type="protein sequence ID" value="MST35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="17853" checksum="34DF376128A73472" modified="2021-04-07" version="1" fragment="single">MPFEFAVLKGRSNYVCVQRVRELDRAGEQTPLTEPGVPAAGLGPLGRELRRLAAWAEDAGSGDRADLPWEPSPAAWAQVSVGARDCPGAARCPSGRDCFAEAARSRAAAADVVVVNTHLYAAHLASHGELLPPHDVVVFDEAHELEDIASASFGVELSPGRFTALARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZR1</accession>
    <name>A0A7K0JZR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001668">
        <property type="protein sequence ID" value="MST35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="18184" checksum="CDB5903952E97B35" modified="2021-04-07" version="1">MTGTDDLLDRNRAYAGGHTGADLPAQPRLRVAVLTCMDARVLPARALGLTEGDAHVIRNAGGLATDDAVRSLVLSQRLLGTEEILVVHHTRCGMEGLREEELLSALEDETGRRPGFDLGGFEDVEEDVRRTVARLRDEPFLLHRRIRGFVYEIETGRLREVAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZR7</accession>
    <name>A0A7K0JZR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redox-sensing transcriptional repressor Rex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001395">
        <property type="protein sequence ID" value="MST35064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="14328" checksum="23CB0D72091FB3E0" modified="2021-04-07" version="1">VAIVGVGNLGHALARYGGFAARGFQVVAAFDVDPGTVGQRVGSVLVEPFERLAEVVSGKGVELALLTTPAAAAQAATDALVAAGVNSILNFAPARVAAPAHVAVRQVDLGVELQILCYYGLQAAAGLTAYDAVDAVDAVDAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JME5</accession>
    <name>A0A7K0JME5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="378" mass="40478" checksum="44B32A446850F07C" modified="2021-04-07" version="1">MSRWRMLTDDAVGAAEGLAFDEAMAIGYGRGHAAVEPTLRLYTYRSHCALVGRYQHLDAEVDLGACERTGTEVNRRPTGGGAIVMGAGQLGVAVATRAPARQRPRDLLERYSQGIVAGLDRVGISARFRGKNDLEVGGRKIAGLGLYLDGNGGLLFHASVLADLDVAFMLEVLDIPAAKLGARAVSAVEERVTTVTRQTARPWDGRSLAPHIAAGFAATLGVVLEAGSPTRDELELTRRLVAERYGTVAWRQEYSPRPDATATATARLDGGLVRLYLALTGDTIKSLLFTGDFNAVPPPLVAIEEALRWKRMDRAVVERAVSACLAEHPDIARPEVIVEAILQAGARLADPPVAAPPRDGSCYFPDDDRAPIGTEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JML1</accession>
    <name>A0A7K0JML1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000017">
        <property type="protein sequence ID" value="MST31200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="493" mass="51681" checksum="1A194860E045D320" modified="2021-04-07" version="1">MADLAGVPSASGSSGFHRSLRLRDGLVLGITVAAVAMASIGGSVGALGAWGAVALWGIACVVAFAQNHLFAEMASMFPDKPGGITLYAHEAWQQHGKAFGALAAWGYWMGWSLSLSVFGLTIGGLVQAEWFPHATWSFSDGAIQVGLVQVIAAGTLILTWLLNLLGTKGVLATNYVVFAFLLIAFAAFIIGPFAAGDWHASNLHWAVSLPGHTLGGLHLAIVWLWLMGWTVASTELGATFAPEMRDPHREVPKVLRWTSLFVLVVVALIPLAAAGALGEKGIANNPVGFYAAEVTKVIGPLGGVVIALVCAALFISMSVGTADGSRALYGMARDGLTLPVLNHLNRHRMPARAMTLDLVVNMVLVFFVGNVLGVIFASNVGYFIAILFALTGFLLLRRERPDAPRPMRLGAWAIPAAVVLSLYTVVLLVVGSLSPKLAGYGGIKEQLIGVGLLVLGLIGYGLTRLQRNRTPAQVGVPTAATGAGPMPADADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JML3</accession>
    <name>A0A7K0JML3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="414" mass="43972" checksum="B81CD7AF4BF6471F" modified="2021-04-07" version="1">MPDRAERRRSWWWALGLGAGFAGIFSCWSLFWLPVVHGVQAWMVPGDIWITARVSEYIRYGAYPYLYQVDSGYYSLPLGALLLTPAVAVADALGLISGYPFTIAHPTMWLVLGPASALFGIPVLLGARRLAYAWGLRDRLVLVQVLALLAAVVPCTAAGHPEDLLAVAGTCFALAAVSEGRWEQAGWWMGFAVAGKQWAVLALPAVLLLCPAGRRRAMTTRVLLLPLALLTPCMVLDHTDALRAMLLPTDPHGVPWGHPGLSVLLAGGVASRWSRPAAVALSVALAARFARRRPARVGELVAVAFVLRALSEPLLLGYYLAPALLVGALALARRRGGLLGVDVACAALVAAWSLPEHVGALLWWSGAAVVAALVVAAQLAAGRSAPPHRRTSSWSEKALRIVGPGADQVAASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMQ4</accession>
    <name>A0A7K0JMQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-containing redox enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000023">
        <property type="protein sequence ID" value="MST31240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="35205" checksum="404CBD4BBBCD9B8E" modified="2021-04-07" version="1" fragment="single">MVPVAPPDRPTAPPPAGLPPARGPITERLFASLGHAPHDLRWQLGAGDGLDDQDDLHLALYCCYELHYRGLRGVDPEWEWEPSLLAVRRQLEHGFLADLRAAVGPVSVDPVAVVPRLWDMAGGGAGPSLSDWVAARADLGQVRELAIHRSAYQLKEADPHTWGIPRLAGRPKAAMVAIQAEEYGDGVAEDMHASLFAGTMTALGLDPAVSYLDRIPGVTLATTNLISLLGLHRRWRGALVGHLALFEMTSVGPMSRYAEGLRRLGVADAGRRFYEVHVDADEGHQHVAADDLVAGLLEDEPDLAPDVIFGAACLGALDERFSRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW2</accession>
    <name>A0A7K0JMW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000031">
        <property type="protein sequence ID" value="MST31285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="50" mass="5255" checksum="3158DB7DB475E556" modified="2021-04-07" version="1">MTLDATFRRCLGCGAPAPFVDQRVSPSAHYAVEWQLLAAPVPAVPSGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN20</accession>
    <name>A0A7K0JN20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_01240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000045">
        <property type="protein sequence ID" value="MST31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11320" checksum="BA7A6C2383F6054A" modified="2021-04-07" version="1">MLLANFMGTDGLIVIVIALIVIFGGSQLPKIARNVGAAGKEFKKGQVDGEEQARAAAAAEAVAPPTPQLVAPPVPEVVTPAPNPDTVTLSKAELDALIEQRLAQKDPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN31</accession>
    <name>A0A7K0JN31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000031">
        <property type="protein sequence ID" value="MST31287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="19091" checksum="15D0035E7810340F" modified="2021-04-07" version="1">MTDAPRPTRSSSGAGRCGCGTASSPPPGPEGSSSRGRAGAARREPLREGGVEAVRGTGPGMTDSPPDPQDGIADALSDLSGQTRALVRREVESAQAEMWSKAKDAAPAAALLALGATLGLAAAASAYRWNLRVLEKALPPAGAALVAVVAYGSGALWAGTRGIQKLRQLPAPLPTRTISETAEQARSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN68</accession>
    <name>A0A7K0JN68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000047">
        <property type="protein sequence ID" value="MST31368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="367" mass="40760" checksum="3D1CB19344383381" modified="2021-04-07" version="1">MRRQRLALYRLTGPAGPFAVASGLAAGDWYRSPVPRARLKELMRRSDRPALRDTALWAGLAVAAAAGGVALWGSWGALPCLLAYGVLYGSASDSRWHEMGHGTAFRTRWLDEAVYQVASFCMMREPTVWRWQHARHHSDTLIVGRDAEIVAMRPARLARILLNLVGLVDVPLALRLLVVHASGRLTAEERTFVPAEEARKVVRTSRVWLAIYLAVIGAAVASGSWIPVVLVGGPRLYGASLFVVYGLTQHAGLGENVLDHRLNTRTVLMNPVHRFLYLNMNYHTEHHMFPMVPYHRLPALHEEIKGDLPAPYPSLWAAYRELVPAVLRQLRDPSSFVERELPPTAAPYHGPVGGILPDRLMTEPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ9</accession>
    <name>A0A7K0JNQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_02470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17623" checksum="129D4748A62E8B0E" modified="2021-04-07" version="1">SLRSIRGTVGNRHSYTTYLGSTLVGQLDLAREATDEAFARACARWPRVQAMASPGGWVQTVALNQLRRSLRRRPTVPTGVDEKVAFDEYALPDRALWAAVAALPERQRTAVVLRYVHDLPAEQIAAAMGIAVGTVGPTLTAAQRRLRAALDGSVTSPEEHAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR0</accession>
    <name>A0A7K0JNR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000103">
        <property type="protein sequence ID" value="MST31602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="25062" checksum="A4856B65C4155CA3" modified="2021-04-07" version="1">MILIVEDDEGIAAFVAKGLKAEGYATTVARDGDEALALAATAGADLDLVLLDLALPGTDGLSVLRRWRSERRGVPVIVLTARDGTADKVRGLDAGADDYVTKPFAFEELLARVRAALRSVEQRSSTELVVDDLRLDLLTKLAWRAGRRIDLAPREWALLELFMRHPDHLLSRSQILARVWDYDFDPGTNVVEVYVSYLRRKLNQPGLSPLIRTVRGAGYRLRDPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV8</accession>
    <name>A0A7K0JNV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ugpC</name>
        <name evidence="6" type="ORF">GHK86_02375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000099">
        <property type="protein sequence ID" value="MST31577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="378" mass="41128" checksum="6A86E1A138E96F0F" modified="2021-04-07" version="1" fragment="single">MATITLEQVSKVYPNGFKAVKEVDLDVADGEFMVLVGPSGCGKTTLLRMIAGLEDISGGTLRIGSKVVNDLGPKERDIAMVFQNYALYPHMTVADNIGFALKLRKLPKDEIDRKVKEAAEILGLTEWIDRKPGQLSGGQRQRVAMGRAIVREPSVFLMDEPLSNLDAKLRVQMRAEVSRIQRRLGVATVYVTHDQVEAMTMGDRVAVMRDGILQQCADPQTLYDRPTNIFVGAFIGSPAMNLYEAVLEDGASGLQVGSQRIPLPEAVRVARPALARYAGQQLVIGLRPEHLPAAGEAAGRNVIEGDIDLVEALGSELLVHFTIDATRVLAEGAHDRDEMAIRGGEGVARVDPRAPMNYVGLQSGRITIYHGRVGGLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP15</accession>
    <name>A0A7K0JP15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000116">
        <property type="protein sequence ID" value="MST31685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="35"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="29252" checksum="0C64EB881993B71B" modified="2021-04-07" version="1">MTATESGFQPRSGKLRIPTPPTFEDPAEEREHRKQRLAGALRIFGRFGFSEGVAGHITARDPELTDHFWVNPFGMSFRHVKVSDLILVDHRGEVVHGDRPVNRAAFVIHSAIHRARPDVVAAAHAHSVYGKAWSALGRPLDPLTQDACMFYGDHVVVTDGGGAIVLDESAGKALAAGLGPHKAAIHRNHGLFTVGQTVDEAAWWFITMERSCQAQILAESVGEPHLIDDDDARYTFEQTGFPLAGWFSFQPLWDEIVRSDPDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP71</accession>
    <name>A0A7K0JP71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Propane 2-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.227</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol</text>
            <dbReference type="Rhea" id="RHEA:49992"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17824"/>
            <dbReference type="ChEBI" id="CHEBI:32879"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.13.227"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.227" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003430">
        <property type="entry name" value="Phenol_Hydrox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02332">
        <property type="entry name" value="Phenol_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="561" mass="65677" checksum="041C327F572EE2ED" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB7</accession>
    <name>A0A7K0JPB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="323"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="596" mass="63509" checksum="42E79280046BEEE9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH1</accession>
    <name>A0A7K0JPH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000156">
        <property type="protein sequence ID" value="MST31860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="541" mass="56589" checksum="FE3F3D2447568BF3" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH4</accession>
    <name>A0A7K0JPH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000160">
        <property type="protein sequence ID" value="MST31872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="197"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="386"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="603" mass="66209" checksum="04FDBE38F944E593" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ1</accession>
    <name>A0A7K0JPJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">GHK86_03955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000162">
        <property type="protein sequence ID" value="MST31880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="275"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="405" mass="42382" checksum="11FA94BF9D939DA1" modified="2021-04-07" version="1">MPSPQAEPTTVSLVGSTGSIGTQAVDVITAEPGRYRVVALAASRSVERLAEQARRLRPDRVAIAEVDRAAELRAAVPAGTEVLAGEGALEAVSVDAQVVVNGVVGFAGLPVTLAALRAGRRLALANKESLIAGGPVVQAARATPGAEIVPVDSEHCAVHQCLRAILGERGMEALPHLPASPLRRVVLTASGGPFRGRRRQELAEVTVADALAHPTWSMGPKITVDSSTLMNKGLEVIEAHELFGVGYDDIDVVVHPQSIVHSMIETTDGATLAQLSMPDMRLPIGYALAYPDRIATAFGAIDWSGLSRLEFEAPDREAFPCLDLAYRAGRAGGSAPACLNGANEVAVDAFLGGRIRWVDIPDVIAAALDDYSPTEPTTVADVLDADRSGRDLALTAVARRVSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM2</accession>
    <name>A0A7K0JPM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">GHK86_03920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="WJHE01000160">
        <property type="protein sequence ID" value="MST31873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="69"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST31873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="30844" checksum="F61A0321920DDE02" modified="2021-04-07" version="1">MNRNTVKTAVVLAALGVLFIGIGGLIGGTTGLFVGLAIGLAFTGGSYWFSDRIAIAASGARPVSEAEMPQYYAVVRDLTERARIPMPRLYVSPAQQPNAFATGRNPHHAAVAVTAGILQICTWEELRGVLAHEISHVRNRDILIASVAATIAMAITLLARMAAWGGLLFGQGRDQGQNIFELLAMLILAPLAAALLQLALSRSREFQADRSGAELIGDGEPLAQALAKLESTSRRIPMPGVRPEMAPMYIVNPLGGTRVDFSRLFSDHPPTAERIARLRSGSWQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR8</accession>
    <name>A0A7K0JPR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000169">
        <property type="protein sequence ID" value="MST31901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="270" mass="29402" checksum="26DED21382BC4C59" modified="2021-04-07" version="1">MAVRLDTIPADRPEHADQEVATIVGRLVARALRVADRPDPADIAVLLCDAHQIAARLPIFDTRLLDAIAAQLPTFPVPQPIHRSTNPKEPITMTTTTDPTYAELLEEVRTLRGLLADRLTAVEDRLDALEAWRRQPIFDTLRAREIIVRDIGGTATGRLYAEPNAARLTLDGGCAEIALVAEDDTPDVPVDPEAPRPDIWLGATRGHAGINVNGDLEYDGPTATMQVFVSRGVEPDPDFLHRAEMAVTTYGSGWQRAALVEGGERAADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV6</accession>
    <name>A0A7K0JPV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="12792" checksum="A502952B68BC2374" modified="2021-04-07" version="1">MTPGRMPMMETVAKRKPRPRRSFTPEFKADIVERCQAGDRSIGEVAKDFDLTETAVREWVKHADIDAGRREGLSSDEREELSRLRRENRRLQADVDLLKRATAFFAKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW4</accession>
    <name>A0A7K0JPW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbamoyl phosphate synthase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000104">
        <property type="protein sequence ID" value="MST31604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="23160" checksum="3CA767816950F5ED" modified="2021-04-07" version="1">FGPLALGEDAIRAAAAAAVGTDGQDLVRTVTTPEAYRVGDGPLRVVAYDFGIKATILRHLAAGATVDVVPATTPAAEVLAAAPDGVFLSNGPGDPAALGWAVDTVRSLLGEVPVFGICLGHQLLGTAVGGRTYKLAFGHHGGNHPVQRLATGRVEITSQNHNYAVADVPGATVTHVNLNDGVVEGLAVPELRAFSVQHHPEAGPGPHDAGYLFEEFRALMAGRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ57</accession>
    <name>A0A7K0JQ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000210">
        <property type="protein sequence ID" value="MST32088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="5478" checksum="56BD17AE504B80B0" modified="2021-04-07" version="1" fragment="single">MTEQPPLAASGWSSSLSVAEHAAVREAGFTPLGLVMGSSVYQLAPVYSPGMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ68</accession>
    <name>A0A7K0JQ68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000212">
        <property type="protein sequence ID" value="MST32098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="10945" checksum="11B2C6C260C6932A" modified="2021-04-07" version="1">GPDHERIGHLNQAFHREIHGAAASRYVAGMLTGLVQMPLVLRTFHRYEPAELRRSMGHHRELVAALRARRPEWAEAVMHAHVEAARVTLRREVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ75</accession>
    <name>A0A7K0JQ75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit NuoF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoF</name>
        <name evidence="7" type="ORF">GHK86_03115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000124">
        <property type="protein sequence ID" value="MST31719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="445" mass="48017" checksum="CF48C7A19AF13BFF" modified="2021-04-07" version="1">MTVTDAPRIVTRRLGRPQSWTLASYLEDGGYDGLRKALSMSPEEVHDAVNVANILGRGGAGFEAGRKWGMLAKSTPVYLAINGDESEPATFKDHALIEADPHQLIEGALICAYAVRADQVFLYVRGEFPLGIERLQAALNEAYAYGAVGRDILGSGWSIDIVVHPGAGAYICGEETALLESLEGKRGYPRIKPPFFPAAVGLYGAPTIVNNVETVSNLPWVMLNGGDAFAALGEGRSKGTKVLALSGHVKRPGNYELEFAKASFRDLIYDPALGGGIREDRELKAFIPGGVSSPWLGPDHLDVLLANEKIAEVGTMAGSGAVTVMDEGTCVVRAAWRIVRFFHRESCGQCTPCREGGGWVEKILQRIENGQGRETDLELLLDVCDNISPGVTWPPAQTTICVLGPSIPPAPAAAIKMFRDEFLIHIREGRCPFPPDRLPRSVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC5</accession>
    <name>A0A7K0JQC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000226">
        <property type="protein sequence ID" value="MST32155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="315"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="456"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="662" mass="71338" checksum="B1DD1FCAC6724492" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD0</accession>
    <name>A0A7K0JQD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exodeoxyribonuclease VII large subunit</fullName>
            <ecNumber evidence="7">3.1.11.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xseA</name>
        <name evidence="7" type="ORF">GHK86_03425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000133">
        <property type="protein sequence ID" value="MST31779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="5">
        <location>
            <begin position="134"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="28474" checksum="0A17A64DE6E237F1" modified="2021-04-07" version="1" fragment="single">MTLPLFEDPVPSGPRTVTLVRLAAEIARQVAAIGPLAVEGEVHRPTTGRTGWVYFTLRDRAAQISVVVPRPKASRSRTVAGERVRVVGALEWSNDRGQLQLRAEEVLPVGAGAIAALLAETRRRLEADGLTARPRRPVPLLPEAIGVVCGADAAVRRDIESVVAARFPGYPVVFHETTVSGPGAAVSIVEAIRVLARRPGVEVVVLARGGGDATALLPWSEEDVCRAVAGCPVPVVSAIGHEADRPLCDEVADLRCGTPSLAATAVVPDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD2</accession>
    <name>A0A7K0JQD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="34715" checksum="43C8A07F2982C38F" modified="2021-04-07" version="1">METRTLGKTGRAVGVVGLGCWQLGGDWGEVDESDAMATLHAAADAGVTLFDTADVYGDGRSERLVGRLLAERPGAGLTVATKCGRRVAQDPDNYTPAALRAWAERSRDNLGLDTIPLTQLHCPPDAVFEDEAVFDALDSLVAEGILGSYGVSVETVAQGLRAIQRPGVATVQVIVNAFRLKPTEELLPACAAAGVGVLARVPLASGLLSGRYDEHTTFGSDDHRNYNRHGEAFDVGETFSGVPYDVGVRAARRLGDSAVPAGWSLPEVALRWLIDTPGVTAVIPGARNGDQARRNAAVAERSPLAPGVGTTIRAVYDSDIRPLVHDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM4</accession>
    <name>A0A7K0JQM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000255">
        <property type="protein sequence ID" value="MST32248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="2">
        <location>
            <begin position="112"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="596" mass="63310" checksum="EB5CD897A1CB8D50" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR7</accession>
    <name>A0A7K0JQR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="99"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="28070" checksum="64546B7C7CF5631B" modified="2021-04-07" version="1">MTRAHQLEASLRALRLSGMLDTLEVRLAQARSGELGHLEFLAMLCEDEIARRDTAAIDRRLKAAHFETTTNLEDYDFAFNPKVPVAAIRDLATLRFVEVGESVILHGPVGVGKTMIAQALGHAACRRGYTVAFTKTSRLLADLAGGHADRTWANRLRRWSRPDIVILDDFAMRDFTAAQADDLYEIITERAGRSLILTANRAASDWYSLFPNPVVAESILDRLVNGAHHLAMQGRSYRPNKRPRRPDPAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW6</accession>
    <name>A0A7K0JQW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="32"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="532" mass="55656" checksum="F48ECB271A3DCF65" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA7</accession>
    <name>A0A7K0JRA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="1">GMPMT</shortName>
            <ecNumber evidence="1">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgE</name>
        <name evidence="3" type="ORF">GHK86_06900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000294">
        <property type="protein sequence ID" value="MST32447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3416" evidence="2">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="1">
        <location>
            <begin position="517"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="656" mass="73105" checksum="5D9B1249FA3A548B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD9</accession>
    <name>A0A7K0JRD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000304">
        <property type="protein sequence ID" value="MST32473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="17726" checksum="AD9E834663E6BFFF" modified="2021-04-07" version="1">MGGDVDSTRWLTEDEQAAWSGLQQMQGMLSGRLNRELATSSGLSLQDYAVLVTLSAAAEHRMRAFELGRLLGWEKSRLSHHIARMAARGLVCRQRCPNDQRGHFVVLTDAGEETLAAAAPGHCRSVRHWFVDRLSPAQLAALADITRTVRAGLGEICDGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG3</accession>
    <name>A0A7K0JRG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_07270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000317">
        <property type="protein sequence ID" value="MST32521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="294" mass="29849" checksum="620B2C5948BC2C26" modified="2021-04-07" version="1" fragment="single">VGYAVGLGLLVPAGDMLDRRRLVPAVLGLTALALVGSAAAPSIGVLIALAALVGAGSVAAQILVPLAASLASDQDRGRVVGTVMSGLLVGILLARTASGIVAGASSWRVVYVVAAAIVVGLAAVLAVALPREAPRPRLAYPALLRSIGTLWRAEPLLRRRAALGGLGFAAFSVFWTTMAFLLAGPPYHYSDTVIGLFGLVGAAGALCANAAGRLADRGHAPAATLGFSAAIAVSFLPIWFGRHSLAALIVGIVVLDIGVQGLHVTNQSLIYRLSAEARSRINAAYMVCYFVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI9</accession>
    <name>A0A7K0JRI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000328">
        <property type="protein sequence ID" value="MST32551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsJ" evidence="2">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="23029" checksum="8B5A188FA9B55B55" modified="2021-04-07" version="1">RLVAAGDPLVVAGPPARFVGRGGEKLDAALDRFALSVRGRTALDAGASTGGFTDCLLQRGAARVVAVDVGHGQLHERLRADPRVDSRERVNVRHLRPGDVGGPFPLVVADLSFISLRTVAPALVAQAAPGADLVVLVKPQFEVGRQEASRGRGVVRDPGAWRAVLVDVASAMQSQAATMMGLMASPIRGADGNVEFLAHLRRDGGDGAEIAGLVEAALAEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK7</accession>
    <name>A0A7K0JRK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029455">
        <property type="entry name" value="GHL15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14885">
        <property type="entry name" value="GHL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="368" mass="40546" checksum="EC5A77A8BA66CBD2" modified="2021-04-07" version="1">MVTTHGGGALHRGAWLRYGGLPISDAEIEFAVEHYAVAVLQPWETAALERLKAARPDMTVLCYKCLSSSRSYEPGPIHTSGVSHVEAEESGEHWFAHRLDEVSRIEWATYPGHWQMAVWEEEYRQRWCDNVADELETTAWDGVMADNDVYDDYYGLRPPIEGQRSMADVRAALDRLVSEAGERLGAIGKLLVPNIAESRREPGRWARHSAYGGGFEEVWLAYGPDDYFDPETALAQTSEARGPGVAIMRVASDGTDGHPNFLYGLATLWIFGNRATSVLSATAHDGYNSTPFIPELDADLGQPAGDPSQRGNGWSRMFTGGWAGVNLNSGRRRKVTYSLPAGLVDVHGKPAPPRITLDPHRGAVFVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL7</accession>
    <name>A0A7K0JRL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF721 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000335">
        <property type="protein sequence ID" value="MST32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="12132" checksum="3C808D1990FA0792" modified="2021-04-07" version="1">MTWQPSTPSPAQREPRPVAASLGRVSERLGLGRPTTLGAVFARWEELVGPDVAAHATPRTLRDGVLTVVVDHPAWASSLRLLAADVLGRVSEAGGEPVGELVVRVAGERPRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR0</accession>
    <name>A0A7K0JRR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21561" checksum="76C6A3201D2487F9" modified="2021-04-07" version="1">MLLLDALVVVWVAGWLAVGIWVAVDVSHLSRLALTLGTAATGLGDAARAIMKLAGIPFVGSTFRGLARSAARTAASAQANAAASRTSVDQLAYLLGIVICLVPSVPVVAAWLPMRVSRIREVRAVRRALASPRHRASLERYLANRALATLPFHQLVALGEDPWEDVSQGRLDALARAELRRLGLRAELLDASPPSNPRRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW6</accession>
    <name>A0A7K0JRW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="9" type="ORF">GHK86_08100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000360">
        <property type="protein sequence ID" value="MST32682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="218"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="411" mass="44983" checksum="FD971C2AD39A7F5A" modified="2021-04-07" version="1">MVHQLTDDALPELLARERFTAYIGFDPTADSLHVGHLQQMCTLRRLQEAGHRPIALVGGATGMIGDPSGKSEERVLLTPEVLAANREGIRAQLGRFLDFSADRAVLADNYEWLGTAGLLEFLRDVGKHFSVNEMVRKDSVRARLEGREQGLSYTEFSYMLLQSWDFVVLHDRFGCRLQLGGSDQWGNITEGVDLLRRLRAVHGFGLTSPLVTKADGGKFGKSETGTVWLDPARTSPYAFFQFWLGTADAEVGGYLRRFTFLDREAIEGLDRATAEHPERREAQRALARELTAMVHGPDEATRAERAGAVLFTEGIADLDAGALESALADAPSTPVAASALAAGLPLVDAFVTAGLAGGKGAARRELKQGAVYVNNRRQTEERDLTPADALHGRFVVLRHGRRTQHVLTVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS21</accession>
    <name>A0A7K0JS21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_08370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000373">
        <property type="protein sequence ID" value="MST32735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="8">
        <location>
            <begin position="602"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="761" mass="78256" checksum="8C2AE300BB9E82E2" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS33</accession>
    <name>A0A7K0JS33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000280">
        <property type="protein sequence ID" value="MST32374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="292" mass="32264" checksum="1DD2DF7E774992AA" modified="2021-04-07" version="1">MAPAFERSRRRASPRYTKGSVLTTAFLFVVGIYFLLPAWWLFVSSTKGPSTLYSSEGLWFSHFELWRNLTGLFSYNGGIYLRWLVNTVLYAGVGALLATVFAGAAGFALAKYEFRGREFVFSVILGGVLVPATALALPLYLLMSKVGLTNTYWSVFLPSMVSPFGVYLARIYAAASVPDELLEAARLDGAGEIRAFFGIAARIMSPALVTIFLFQFVAIWNNFFLPLVMLSNERLYPVTLGLYSWNDQYGQAPQLVSYVIIGAAISVIPLIVAFLSLQRFWRSGLTSGSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS52</accession>
    <name>A0A7K0JS52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">csrA</name>
        <name evidence="4" type="ORF">GHK86_08595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000386">
        <property type="protein sequence ID" value="MST32778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="11057" checksum="AE092260DC7F99F1" modified="2021-04-07" version="1">MLVLTRSANQSIVIDEEIVVTVLDVRGEHVRIGISAPDHIQIHRQEVFEAVQEANRRAAESSGDLSSLGGLADQPAPGAATADGARQPARRSPRQEETPPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS57</accession>
    <name>A0A7K0JS57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000389">
        <property type="protein sequence ID" value="MST32786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="29986" checksum="FFE3DBE1ECA19FC3" modified="2021-04-07" version="1">MTTVGIVVPTRNSARTLRACLLSLRAQTRPCSVVVVDNHSTDSTGAIAEELADRVLVRGPERSAQRNAGAALLGTDVVGFVDSDMVLEPSVVEEAAAAAVAAGAGAVIVPERTVGEGFWAAVRALERSFYVGDDRVEAARFFTRSVLDATGGFDESLDAGEDWDLSLRARRITSMARTSAGIDHLEGRLTYRAACAKKAAYSSGLRSFHAKHDSATLWRALDRPYLRRPWRLLTPDPLLGAGVLALKAGEAAAVVWALTRDGSRRRAATTPAVTHEEHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS92</accession>
    <name>A0A7K0JS92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000396">
        <property type="protein sequence ID" value="MST32811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="372" mass="38282" checksum="669583DCC7F4F272" modified="2021-04-07" version="1" fragment="single">MRGLLERLFPGRLGAGFRWLVASAWVANLGDGFAFAAGPLLVASQTRNPTLVALATLLQRLPWLLFGLVGGAVADRVNRVVLTATVEVLRAGLLALLAVAILTGGVDIAVVLATLFLLGTAEVFSDTAATTVLPSLVGADDLTLANSRVQTGFVTLYQLAGPPVGAALFALGAAVPFVAQALLVALGAVLVSRVRLPGRRAAAGAGTTAAGNAPGVARRSMRAEVVDGFRWVAQHAAVRTLVLTILIFNVTFGAAWSVLVLYAEERLHLGAVGFGLLTTASAVGGLLGTTGYGWLTRRVSLGNIMRAGLVIETLTHLSLALTTSPAVALAVMVVFGAHAFVWGTTSITIRQRAVPAPLQGRVSSVNSLGVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB8</accession>
    <name>A0A7K0JSB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <ecNumber evidence="7">1.2.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argC</name>
        <name evidence="7" type="ORF">GHK86_08795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000399">
        <property type="protein sequence ID" value="MST32817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="16632" checksum="FFC095FFFEC3DA84" modified="2021-04-07" version="1" fragment="single">MLGASGFVGGELLRLLGAHPHLDVVAAGADRQAGRDVADVHPHLGTYRGLTLAESTPSALDGVDVAFLALPHGASAALVPDLLERVPLVVDLGADFRLRDPEAYPRWYGEAHPAPDLLAGAVHGIPELYRDRLPGARLVAAAGCYVTAASLALAPLVAAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD6</accession>
    <name>A0A7K0JSD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoenolpyruvate synthase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_08875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000402">
        <property type="protein sequence ID" value="MST32833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="335" mass="34735" checksum="94CE305B04CA8CE3" modified="2021-04-07" version="1" fragment="single">MAYVAWFRDLGKSDTAVAGGKGANLGELARAGFPVPDGFVVTAEAYLTTMDASGVRAELRAAAAGGGGTNSLAATAKRLQDLVRTSPVPAAVGQAVEAAYRQLGTEVTVAVRSSATSEDTEGVSFAGMNQTFTNVRGAARVVERLQECWASMFGERVLAYRATRRITEEPAIAVVVQRMVHPAASGVMFSADPATGSRDTIVIEAAFGQGEVVVGGEVEPDTYTLVKSTLAVRDVRVGVKRRRIDAGPDGDRVVELGADQASRRVLGDDQLVALGRLAREVEDHYGEPQDIEFAIPEDGSVWLVQSRPITTLAAPGAGTGAPGPGGTGGGPATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN8</accession>
    <name>A0A7K0JSN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AarF/ABC1/UbiB kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000440">
        <property type="protein sequence ID" value="MST32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="116"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="553" mass="60201" checksum="190A4E7762BD0C11" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR4</accession>
    <name>A0A7K0JSR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7556" checksum="31644B47F7A59054" modified="2021-04-07" version="1">MPWCDDCSKFWNPPSLGDHGECPTCGTVIAKPARNAPWHFKVLLVGLVGYLIYRVYWLATWLPKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU3</accession>
    <name>A0A7K0JSU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acryloyl-CoA reductase</fullName>
            <ecNumber evidence="3">1.3.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.95" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000457">
        <property type="protein sequence ID" value="MST33018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014188">
        <property type="entry name" value="Acrylyl-CoA_reductase_AcuI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF1">
        <property type="entry name" value="PTHR43677:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02823">
        <property type="entry name" value="oxido_YhdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="33740" checksum="E28A73E426AA2801" modified="2021-04-07" version="1">MPVRAVVSTGQGPAQLTELDDEDLPDGDVTVDVAYSSLNYKDGLAVTGRGRIVRRPPLVCGIDLAGTVAESASPDWSPGDEVVVTGWGLSETHPGGYTERQRLRSAWLVARPPGLTLAQTMAVGTAGLTAMLCVLALEDAGLSAGDGEVVVTGAGGGVGSVAVALLAHLGHRVVAATGRPALHEYLRGLGAADFVTREELARAAERPLESARWAGAIDTVGSTTLASVLRQAAYGAPVAACGLAGGDDLPITVLPFILRGVRLLGVDSVQCPTPRREQAWARLAADLDPDLLDRMTTVEPLTAVPRLAEDILAGRTQGRVVVDVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW8</accession>
    <name>A0A7K0JSW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">GHK86_09940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="WJHE01000464">
        <property type="protein sequence ID" value="MST33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="261" mass="27415" checksum="DDA670F878BA4023" modified="2021-04-07" version="1">MSDRRPLVSGNWKMHLTHLEAIQVVQKLSYALDRGPQGEVEVSVHPAFTALRSVQTVLDADEIPVALGAQDVHWEDKGAWTGEVSPTMLAKLNVRYVIVGHSERRQHLGETDEWVNRKLRATLRAGMTPICCVGETAAQRDAGETRDHVVGQLHAALEGVDAAAVAGVVVAYEPVWAIGTGRTATPEDAQAVCAALRAAVGERWGADAAAGVRIQYGGSVNEANAADLLGQADVDGALVGGASLDPVAFAAVVAAARPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX9</accession>
    <name>A0A7K0JSX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000469">
        <property type="protein sequence ID" value="MST33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="28954" checksum="8A0587D1D0F56CF4" modified="2021-04-07" version="1">HPGSPQPEGPHPGSPQPDGPHPGSPYWSAVAPGRPGAPPTGPADAPPELDGGPGGRIPARAVWWGVLGIAAGEVVGSMLALLLVAATGLRVTSAGPELVGELGLWSGMLGAVVFVSRRYGSGSLRRDFTFAFRWIDLAYGLGAAATGLAIAQIVAVAFAGSRLAGSNTQILTGQQGNTFGIVLVTLIAAVGAPFFEELFFRGLLRTALAARFGRHGAVWGQAVLFGFAHYGEAHGLGNVSVVLALILLGVVLGYTAMLTGRLGAGIVAHSLFNLTAAVTIFVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT67</accession>
    <name>A0A7K0JT67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_10475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000500">
        <property type="protein sequence ID" value="MST33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="236"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="459" mass="50248" checksum="01EA3C7331B1F144" modified="2021-04-07" version="1">MSVAATRRRVPSTLGPPPPTVPPLRREAPTIALGIAALGLGIVVALAFSDETAGAWRLRGGPAIFIGSLTGLVGTYLAMLMVLLASRLPFVESALGFDGLLRWHRRLGPWPITLLTIHAVVLIIGYAQAARTGALHEIGAMINGYAYMLAAFVGLGLMLMAGFASVRAVRRRVKRETWWVIHLYLYLALALAFAHALVLGPDFVNHPVTKIVWCVVWAATAGSVLVFRFGVPIARSVRHNLVVWEVRRETPDVASIILKGRDLDRLPLEGGQFAEWRFLTRGLWWQAHPYTVSGLPQRGYLRITVRGLGDHSRTIARLRRGTRVAFEGPYGVFTAASRRRHRVTLIAAGVGVTSLRPLLEELPAGTQPTVILRAPSAETMPLRAEIAGLVEAQQGVLHELYGSRRAHVLDGRRLRQLVPDIVEQDVYVSGPEDFVADVAATVRRMGVPDEAVHHEAYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT79</accession>
    <name>A0A7K0JT79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="6">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">truA</name>
        <name evidence="8" type="ORF">GHK86_10380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000491">
        <property type="protein sequence ID" value="MST33123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="7">
        <location>
            <begin position="163"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="28818" checksum="6F5DC0228290833A" modified="2021-04-07" version="1" fragment="single">MTLFSEQAGPEAPAAVTTEPVARVRLLVAYLGAGFRGFALQPGQRTVAGVLVAALERHLRHTVEMVCAGRTDAGVHAWGQVVTLDVRAGADLRALVRSLNRALHGEVVVRAAAWAEPGFDARHSATSRRYRYSVLNRPVADPFRAQVTWHVERPLDLAAMRLACDPLFGEHDFASFCRRPAPEASLVRRVGDARWVDEGDGVLRFEIEASSFCHQMVRSVVGMMVEVGKGKKRAGEVAGIIGARDRSAAGGMAPPQGLCLWQVGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB9</accession>
    <name>A0A7K0JTB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">GHK86_10725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="WJHE01000513">
        <property type="protein sequence ID" value="MST33192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="14808" checksum="B5DE1DDE9AD36515" modified="2021-04-07" version="1">MDRTLVIAKPDAVARGLAGEIISRLERKGLRLAAAELRTIDRETAARHYAEHEGKPFFEDLLAFITRAPALFLVVEGPKDTWKVVRTLMGATNPAEAAPGTIRGDLGIEMTENLVHGSDGPESAAREIGIFFPSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ9</accession>
    <name>A0A7K0JTQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dna2/Cas4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000560">
        <property type="protein sequence ID" value="MST33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="29441" checksum="4969138843AE3F5A" modified="2021-04-07" version="1">MALPLPTSLSPTKVTTFKDCALAFRLANIDRLPEPSSVAAAKGTVVHRALQLLFLEEDAAGRTLEAALARLERAVPEVLGDAEHADLDLDGDALAAFVADAETLLRHEFELEDPRQVRVVGTELRLSVQLGSLRLTGIIDRLELDDDDRLVVTDYKTGRAPSQGYEQARLAGVHFYALLCEEMLGVRPARIQLLHLREPLTISTVPTDQSLRAWRQQTAAVWSAVERACDDEDFRPRPGRMCAYCAYHSYCPAVGGNLALLPTKVGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV0</accession>
    <name>A0A7K0JTV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1275 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="24391" checksum="E06FA2338525A174" modified="2021-04-07" version="1">MNALMQLRLDQRLVVAMAGLTILTGLVDATSYLGLGHVFTANMTGNVVFLGFAFGGAAGFSISASLVALAAFLAGALIGGRLVGADHSARRAAPVFALQSVALVAAAVVAWAVDKPGIGASRWALLALLAVAMGLQNAAARRLAVADMTTTVLTLTLTGIAADSRLAGGSDSRIARRGASVLLMLAGAAGGAALKAQGLGWPLTAGATLAVATTIWMTSTPSESSPTKPSGTTITTDDPATTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ9</accession>
    <name>A0A7K0JTZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rod shape-determining protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_11860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000583">
        <property type="protein sequence ID" value="MST33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="367" mass="38909" checksum="0DA1DC35690BE206" modified="2021-04-07" version="1" fragment="single">MTSLIDDRPAPGATTRRRGPTPWRHLDPVLVLAVLAIAAFGVVMVWTTTRIPLETAGLSGIATAKKQAIFCVIGVGVMFTVAAVDYRRYRDWAPLLYGLSLFLLAGLFVAGHRSNGSQGWFQVGPLQFEPSEFAKIALIVALAAYAATFKGRLAGKSLLAVIGMGAVPFVLVYKQPDLGSGLVLLAVLAVVIVVAGARSRHLAVLGLIAVVAMVAVVQLGILKGYQQARLTSFLHTPNKVSQQVLQSPAGVNIYNVVESKDAISHGGVLGRGIGHGSATNLSQVPEQSTDFIFSAVGEQVGLAGSAVLLVLFLVVLWRTWQAAVLSRDLFGRLLCAGVLGYLLFQTFENIGMTMGIMPVTGIPLPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU29</accession>
    <name>A0A7K0JU29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_12010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000596">
        <property type="protein sequence ID" value="MST33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="22245" checksum="B22CE602B8A9302F" modified="2021-04-07" version="1" fragment="single">MAYEVVGLLGRGATAVVELALDPGGRPVAIKRCALTGSARQIDQARRRLRREAELLRSLDHPALVPVLDVVDDGSDVVLVLPALAENLEDRVARLGHLAPDELARIGRRLLDGLAAAHRGGVVHRDVKPANVLFDAEGLPALADFGVATSSGVTAGLTGAGAVVGTPTWMPPEQARGEPAGTAGDVFGLAATLVWAGTGQTPYEPGPATAVLARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU50</accession>
    <name>A0A7K0JU50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_12170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000607">
        <property type="protein sequence ID" value="MST33472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9356" checksum="1BFB0C18B6F18AE6" modified="2021-04-07" version="1">MPQLGETVTEGTITRWLKSVGDPVAEDEVLFEVSTDKVDSEVPSPAAGVLSEILVAEGDTVDVGTRLSRSTATRRSRPSLKVPMRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF4</accession>
    <name>A0A7K0JUF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000649">
        <property type="protein sequence ID" value="MST33585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="65" mass="6625" checksum="2433FD40E0CA1054" modified="2021-04-07" version="1" fragment="single">MRTSVVIVCLQPGDWLEEAIASVVDQADQVVVVDNGSADGAASVVARRAGAAVVRSERNLGFAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG2</accession>
    <name>A0A7K0JUG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_12660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="WJHE01000640">
        <property type="protein sequence ID" value="MST33568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="334"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="476" mass="48870" checksum="EDBB1A2865D3EF7B" modified="2021-04-07" version="1">MAERRECGPWPREGEPRPAGRARRLCVVGAGYVGLTAAACFAHLGHDVRCVERDAERLGTLLEGGIPIHEPGLAELVAAGLRSGRLGFTDDIGAALEGAEVAFLCVGTPPQASGEPDLSLLAAAAREAARHASGDVVVVVKSTVPPGSCEALELVCAEEAAPGVRIRVASSPEFLRESRAVEDFLAPDRVVVGAEDADAAELVAGLYPEGCPVVVCDRRGAELVKYAANTYLAIKISFANEVAQLCDALGTEAQAVLAGVGADHRVGPEFLRPGPGYGGSCLPKDVAGFIALGEAAGTRTTLAAAAEAQNAHARRSVVHRLELVLGGLSGRQVGVLGLAFKDGTDDVRDSPALQIVADLVAAGAVVTCYDPLAPSFLALGTRAATVSGAIVGAEALVVAVASEEYQRLDPVTAARSMAGRVVFDAAGILDLERWTAAGFSVYGVGRGMPLAFYPVVWTPLRWTTAGKSPGAEAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ6</accession>
    <name>A0A7K0JUJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="6811" checksum="EA3FEFE8149AC11B" modified="2021-04-07" version="1">MDAADPGGLPRVVTAVEQRLDGHLAALLNSAGTALKRPDGAGLGVVDAPTAVWQQVLAVNCRPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN7</accession>
    <name>A0A7K0JUN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000682">
        <property type="protein sequence ID" value="MST33666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02209">
        <property type="entry name" value="MurL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043689">
        <property type="entry name" value="MurL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="418" mass="44693" checksum="60D2923D60601CEF" modified="2021-04-07" version="1" fragment="single">MTATPREAGRGGFGPAAAFRYVGWDVDPEGGQLACRYALDGREFVERVRVEADPAAWRTPAAGEAARLVFLLAGVSYYKAGAPPVLDLGTTPVRPGDGALLLDFYRQGLGEFAYRNDLDLAALRLVGGAELGPPVGREAPADAPLVPFGGGIDSIVTVEGVRARRPAGGTTLFVLSREGDRFAAIEDAAAATGLPVARASRALDPAILDSASQGWLNGHVPVTGVLSAIALLVAVLRDHDAVVMSNEWSASIGNVELPGGGSVNHQWSKSLAFEELLRSHLARSIAPPPAYFSWLRPWSELWVARRFAELGEYHRVFRSCNRAFALDPGRRLDHWCGRCDKCCFIDLVLAPFVPAATLRDVFGGREPLDDPSLAPRFRALLGRSPDVKPWECVGEVGECRAAAALAAARPDRARSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS1</accession>
    <name>A0A7K0JUS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000692">
        <property type="protein sequence ID" value="MST33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="12005" checksum="037B9380BC91C76C" modified="2021-04-07" version="1">MELGLEVDESRPPYTVLAVKGEVDVYTAPRLREKLVELASQGRNQIVVDLEGVEFLDSTGLGVLVGGLKRLRSNDGDLGLVCTQARILKVFEITGLTKVFTISGSVDEATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT7</accession>
    <name>A0A7K0JUT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (NAD(+))</fullName>
            <ecNumber evidence="2">6.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ligA</name>
        <name evidence="13" type="ORF">GHK86_11130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000539">
        <property type="protein sequence ID" value="MST33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="596"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="698" mass="74646" checksum="2135B6A868CB1505" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ3</accession>
    <name>A0A7K0JUZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000725">
        <property type="protein sequence ID" value="MST33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="13484" checksum="25D0DEFA2BF6A32A" modified="2021-04-07" version="1">MATVALTKDTFESTVTTNDVVLVDFWAGWCGPCRAFAPTYEAAAERNPDIVFGKVDTEMEAELAAQFGIMSIPTLMAFRDQILLYAQPGALPAPALEELIGKIKDLDMDDVRRQIEERAAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE2</accession>
    <name>A0A7K0JVE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000779">
        <property type="protein sequence ID" value="MST33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="46" mass="4444" checksum="80349DD96965D01F" modified="2021-04-07" version="1" fragment="single">MTPGQLRTLAAVAQAGSVVGAAEALHVSQPAVSASMAALAREVGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ3</accession>
    <name>A0A7K0JVQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000794">
        <property type="protein sequence ID" value="MST33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="48"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="430" mass="46441" checksum="20126B3EE26CB219" modified="2021-04-07" version="1">MARANGKLNGFAGKKPARYSAFDLVRHGVVHGEWPRVWRSHELKSSYDVVIVGAGVHGLATAYYLALNHGPRRVAVLDRGYVGGGNSGRNTAIVRSNYLTPEGVRFYDRSVDLYEHLSADLNFNVMFSQRGHLTLAHSDASLRTMAWRAEVNKLEGIDSSVIGPEEIKKIVPYLDTSEHTRYPVLGALYHPPGGTIRHDAVNWGYARGADARGVEIHQQTEVLGIETAGGKVTGVRTDRGHISTPVVVNCTAGHATLLSDMVGVKMPVITHPLQAAVTEPVKVFLDAVVVSGTLHVYVSQTDRGELVFGASTDPYASYSMRGSLEFTEELAGHVLELMPAISKMRLLRQWAGLCDMTPDFSPIMGVTPVEGFLVDVGWGTYGFKAGPVAGETMAELIATGRTPELIAPFDLARFAEGRLVGEKGAASVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV0</accession>
    <name>A0A7K0JVV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000835">
        <property type="protein sequence ID" value="MST34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="10143" checksum="A2BBBEB736698425" modified="2021-04-07" version="1">MPDQLDVEAMIDRFRARARAVRQRPLPPVEGAERKRFVDQMRIDFQDYALIGDAVARLDDGVLTLTIDLRPTPGDGGSGGPADDGAARGGPGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW40</accession>
    <name>A0A7K0JW40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000878">
        <property type="protein sequence ID" value="MST34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14662" checksum="2E83C0247B4BEFA6" modified="2021-04-07" version="1">MAVACLFDRIVAGEVPAHVVLDEPDIVAFLDHRPVFPGHALVVPRVHVATLAELPEALLGPLLAAARRIAAAQRAALGNAGTWLALNDVVSQSVPHVHVHVVPRRPKDGLRGFFWPRSRYADDAEAAATAAAIRAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW87</accession>
    <name>A0A7K0JW87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000899">
        <property type="protein sequence ID" value="MST34216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="16099" checksum="1366700E2EC21164" modified="2021-04-07" version="1" fragment="single">MRDHVDVDRLVELTSALVAVDTRNPPGNERAIEGVVRDALDPFDPRWQEVEPAPDRLSLVAAVPHPDGPGPRPTLVVNGHLDVVPVKADQWSTDPFVPTLRDGRLYGRGTADMKGGVAAAIHALDVLARAGRAPAWDVVFHLVADEEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW94</accession>
    <name>A0A7K0JW94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000906">
        <property type="protein sequence ID" value="MST34230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14899" checksum="7EF0C600A32B6D11" modified="2021-04-07" version="1">MSDEDAAPETGGVTAELLAAIDLGPEIEGMAGRQLRMRVFTFQPGAVLGPLHDHKGRPGVVYILQGTITDHRDGVATDYGPGVGWPEDRNTTHWLENRGSIPAVEVSVDIVVSEGRPTETTRHAPLPRDRRPSTRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB7</accession>
    <name>A0A7K0JWB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000883">
        <property type="protein sequence ID" value="MST34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="12648" checksum="38F2AACF13667CC5" modified="2021-04-07" version="1" fragment="single">MPVVDGAVVDDVEPEVPERPAVVVEVIVDVVVLLVAVPVLAAGVLVVVVVLAVPVPAGVVVVVVVDGVGVPGLEPKKLVPPWDVLEPTTVARGSLASISAAVTPPTANSAVRTAARARGARRRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ3</accession>
    <name>A0A7K0JWJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000944">
        <property type="protein sequence ID" value="MST34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="17032" checksum="0158F99C3FA6F74A" modified="2021-04-07" version="1">MGWYPATSRRYLPDVPDILIAADAPPVYREIASVLSGPGTTVRWVRAGQDVRPEHDRQPADLVVLDLQIGTMGGIAVALDLRLEVDAGRLLPVPILVVLDRRADVFLARRAGVDGWILKPLDPIRVRRAAAALLAGGSWYDETFLPDPVAVPAGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP6</accession>
    <name>A0A7K0JWP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000969">
        <property type="protein sequence ID" value="MST34367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="32159" checksum="F4A1B87884FE0D28" modified="2021-04-07" version="1" fragment="single">MTVDAAVPLPAHPAGVPWPTSTWPVAEPPPAWDLAGRVEEMVAQPERFGQTYAVAVAHRGSLVLERYEGALEHWDRPAEPVGPGTGLLSWSVAKSVLHAAVGILVGEGRLDPAAAAPVPAWAAAGDARSAITLEDLLTMRDGLDWVEDYDLAASRSDVITMLFGGEDAAGAADMAAFAADRPLAAGPGTRFSYSSGTSNILSGVVADIVGRSDAYLAWLEKAVFAPLGMTTARARLDPAGTWVASSYLHASARDWLRFGELYLRDGVWEDRRLLPAGWVDHGRRPRSADEDGVWFGAHWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS3</accession>
    <name>A0A7K0JWS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000985">
        <property type="protein sequence ID" value="MST34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="16263" checksum="03783FD0DA0E6599" modified="2021-04-07" version="1" fragment="single">DTLAAVKGLAGARFVVAVDTFLTRSARKADVVLPAAAYAERRGTFTNLEGRISHLGAIVTAPGIAWPDWMIAAELAYRLGADLGFSSIEEVWDEITRVSPLHAGVDRQLLTGPHGRDGIVVPLPEGGLRLRAARPLDPMADPGIASAELHAVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS6</accession>
    <name>A0A7K0JWS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF541 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000976">
        <property type="protein sequence ID" value="MST34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="21675" checksum="D90FBC20DBA39671" modified="2021-04-07" version="1">PAATACGGSPTVTATATGQVSARPDTLLMDLGVQAKATTARGALVADDTKAARLVAALRAAGVPAADLQTSNLSIGPDYGRHGVTGYTVANVVAVTLTKLASANRILDEAANAVGNGIQFDNLQFALTNDTAPAIEARVRAVQRAEGRARAMATAAGVSLGPLCSISDVSSPITVVSGNSGFASAGVGSSGAAVPPTPIESGSQSVTAQVTVAYEVATATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY8</accession>
    <name>A0A7K0JWY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">npdG</name>
        <name evidence="2" type="ORF">GHK86_17265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001019">
        <property type="protein sequence ID" value="MST34463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="23595" checksum="56FC32037B875EB7" modified="2021-04-07" version="1">MAPATCQARGVRIGVIGATGPAGQAVAVQFAGIGDQVVVGSRSEERAAATVGELRDRWPDRELDLVAGDNRAACDADAVVLATPWEGVPATLADLADALEGRLVVSMVNALAKWGRYMVPLVPPTGSVTAAVALALPGSRVAGAFHNLPAGPWADLEHPLDADVLVVAERRPVAREVTALVDRLPGLRGIDAGNLANAAAVEALTATLVGINIRYKAHASLRLTGITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX33</accession>
    <name>A0A7K0JX33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF433 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001047">
        <property type="protein sequence ID" value="MST34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="6671" checksum="6F39035E23F2DA40" modified="2021-04-07" version="1">MGGVPCIRGTRIPVATVVGMVAEGMTTAEILQEFPQLSDADIVEALRYAAAAVDERGLPLRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX94</accession>
    <name>A0A7K0JX94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="7" type="ORF">GHK86_15775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000884">
        <property type="protein sequence ID" value="MST34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26279" checksum="6B02CC64C0D9D532" modified="2021-04-07" version="1">MTKRLDGRAPDELRPLELTRDYTTFAAGSVLIRVGRTVVLCTASVADDVPRWMRGTGRGWVTAEYSMLPGASAERVDREAARGRQSGRTQEIQRLIGRSLRAVTDLPAMGEVQITVDCDVLQADGGTRTASVCGGYIALHDACSRLVASGRMRTHPLREAAAAVSVGVVDGEPRLDLAYEEDSRAEVDMNVVMTASGRFVEVQGTAEGEPFARSELDALLELAGVGIGRLLDAQATVLSVPPALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD7</accession>
    <name>A0A7K0JXD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_17665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001062">
        <property type="protein sequence ID" value="MST34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="34510" checksum="66FA716FE1859961" modified="2021-04-07" version="1">MGSDDDAEGGRPAPEGGEVELDEPVRPAVTVVPELPREETLERSFDRIIEEGRPRLRRTWLDTVATGAVGGMEVAFGVLALLLVESRTGSQLLGGLAFSVGFIGLLLGHSELFTEGFLVPVTVVAGEARVRDLLRLWAGTLAGNLAGGCLMAYLIDVAFPSLSTTAVHVAAYYIREGITARTFVLSVLAGAAITLLTRMHQGTDSEVAKLVASVAIAWVLAGFRLFHSILDSILAFTALNTGRATFGWEDWLTWVGWVLFGNLTGGLLLTTLLRMVRARARLIDHRVAKGLPVPGVSTSGVASPGHTPAGHTPAGHGPTTPRPADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS3</accession>
    <name>A0A7K0JXS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001196">
        <property type="protein sequence ID" value="MST34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="388" mass="42332" checksum="E825FA6A6DF273E4" modified="2021-04-07" version="1">MYGLSTEDLALQARARELGDELIPWEEHAEAHEGRLPPEVAARARARVDALGLRATNMPAELGGGGCTMLQQVLVQEQVGRVTNGLMWFVSTPPQWWAGVATPEQTERWLRPTVAGERSECYAITEEGAGSDVADVVATARREGDGYVLNGVKWHVTSYNHADYVFFEGVLTDGPAAGGHALFVVDLPTDGVSVVRNPAYSHTLDHHHPVVAFDDVRVPAANRIGEEGDGMTFSYAWFRFERFMVAARCVGAAGRLLDEATAFASGRVVGGQPLIERQLVGAMLADSAAELFAARSMLYEAARGVDEGRDLKIQHAQASMVKLYCSEMAGRVADRAVQVFGGRGYMRENVAERFFRELRVERIWEGTSEIQRVILAAQLAKRGAAALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU4</accession>
    <name>A0A7K0JXU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arginine deiminase</fullName>
            <ecNumber evidence="1">3.5.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001203">
        <property type="protein sequence ID" value="MST34767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="15103" checksum="26037FD474BCE72F" modified="2021-04-07" version="1" fragment="single">MNPIPSPGVESEVGRLREVIVHRPGLELSRLTPGNVAELLFDDILWAKRAREEHDAFVGTLEDYGVEVHHFGRLLAETLDIGAARAAVLDRVCTPEAVGPGLVDRLRAVADDLDGATLAEYLVGGVVKADLAGPLHRRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY6</accession>
    <name>A0A7K0JXY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001195">
        <property type="protein sequence ID" value="MST34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="21844" checksum="DA6DFEF8A381CB99" modified="2021-04-07" version="1">MGTLHWEDGRAEVHRLVVGPIDNNVWVVRCKQTGAAVLLDAANEHERLLELCARLGVGRVLETHGHWDHIQAVPAVRDAGYDVAVTAADADMLPSYDSLLEDDAVIEVGRLRLRTIATPGHTPGSMCFRLEGSPLLFSGDTLFPGGPGATGFPGGDFATIIRSIDERLFGPLPADTVVLPGHGADTTIGDESPHLQEWVDRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY18</accession>
    <name>A0A7K0JY18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001262">
        <property type="protein sequence ID" value="MST34861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10962" checksum="FDA948E508B9AB12" modified="2021-04-07" version="1">MVLLDRGETVAAGGYRYLAEGVCELKRMWTRPDRRRSGLGRRLLTALESEARSAGYRRLLLETGPAQPEAVGLYTAGGYEPVAPYGRYPTALAFAKDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY71</accession>
    <name>A0A7K0JY71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001024">
        <property type="protein sequence ID" value="MST34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="28687" checksum="4EB229282A840D5F" modified="2021-04-07" version="1" fragment="single">PPPARLDVGVDLASRDRATVGGMVATNAGGLRVLRHGHVRGHLAGVEAVLADGRVLRRMAGLKKDTAGYDLTGLLCGSEGTLAVVTAALLRLVPLETDRVTALLGVGSVGDALAVVRRLRAGVGGVESAEIMFPEGVALLEDLLGVRSPLGRDCPAQLLVDVAAADPDPVLSVLAACPEITDSAVSADGPGRARLWALRERHPDLVARLGVPHKLDVAVPLGTLADFEVEVRAALARLPVTVVLYGHVGDGSLHVNVATPAQGAGEVEDAVFGVVQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF9</accession>
    <name>A0A7K0JYF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02680 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001071">
        <property type="protein sequence ID" value="MST34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="344" mass="38221" checksum="ACF256A0127754FA" modified="2021-04-07" version="1" fragment="single">MTDQLFTVPAPEPPPLRPPERLGRWVLHRAGLVNVWQYDRAEILFAGGRALLRGKNGAGKSKALEVLLPFLLDGDTRAIDAAGRDRTSVYWLMTDGREPGNHVGYVWLELRRSEPDGEERFVTLGAGLKAASSTRSHSSWFFVAEDRRVGVDLDLGPEVSAERLRELLGSDAVTSAAEHRRRVALRLFGLHDETRYANLIRLLHRLRDPNIGNRIEAGDLATILSDALPPPDDHHLEMAAERFDTLEQIKEQLDRAQRTATALARFLDTYRGYARGVLRDRAGALLAADDQRRAAARELKRLEGQSADAAAAVAAATAELTRLRDEERTAGRELEGLRASDAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI1</accession>
    <name>A0A7K0JYI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001366">
        <property type="protein sequence ID" value="MST35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="25638" checksum="0BEE04E28DA21A23" modified="2021-04-07" version="1" fragment="single">MARETGLALVTLGVVLFLFVAYQLWGTGFTERHDQSVLQQQFQKLHVEKVHHAPATTVGSATGGTGATHSPVVGSAGGSVAAGNPASDGTLTPSPPSGSAIDHLVIPSIGVDKYVVQGVAEQDLSEGPGHYLGTPLPGQRGNVGIAGHRTTYGAPFFELGKLKRGAWIYLTDTAGHTFDYRVLRQHVVAPSDVGVLDPSRRAILTLTTCNPPYSATTRLVVVAALVGRPATATAVAPAGTAGTSGRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ6</accession>
    <name>A0A7K0JYZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001484">
        <property type="protein sequence ID" value="MST35170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="18688" checksum="944CEE8310ECD432" modified="2021-04-07" version="1">MTQPDYVPVRPTDRVRPSDRLNVPGAWRQDRPGEVLDLTPPAGDRFGAAGPDLGYGLKLAKRLEHQLQVPAGEDVEDAVAGCFACGARRAASFGRAPVIYDFQWAYTLWGYLGQAPADLVAARAPVLRGAAHDYWHQRRVVDAVDDEALRLTPQQVAARIGEWRSFLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ10</accession>
    <name>A0A7K0JZ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001483">
        <property type="protein sequence ID" value="MST35167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="231"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="39528" checksum="386ED875D6BE68AB" modified="2021-04-07" version="1">MRGMGRVRWGRSERSAAARDERAAAGMRRLLLEGFRASTPLEAARVVAAVLADRLGAERTAVLFFTGPGRLQVQLATVGIAPTVEAAIRESLDRLERDPTRSPGWTRNRTATAVEVVPDVTGHPIRPGGVVDLCGGRAYLGVPLLGPDGPVGTVICCVGAPRRWRAEEIEDATRLAMGGAAVIEAARRGEAERRTRSELEYRATHDPLTGLVNRGAFADQLTHALEACDGCGVAVLVVDLDRFKQVNDRLGHAAGDRLLELAAKRLAAAVRPTDVVGRLGGDEFAAAMTAEQAGPVALGTAERIATSLALPFALGPDTAAVEASVGVAVSPDHGRDAETLLANADAAMYHAKRTGRAFSLYRLVAGAPPALRRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ20</accession>
    <name>A0A7K0JZ20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001519">
        <property type="protein sequence ID" value="MST35211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="10628" checksum="C3CBF6A70ACF0DFF" modified="2021-04-07" version="1" fragment="single">MMQLLVPLQLHAAGRSSQDIGFTLSAGAVVYIVVSALSVQLGPRITNRRANAAMAALMALALLPALLGSATAWVITALLLTVVPRAVTGTVAYALATGDREEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ44</accession>
    <name>A0A7K0JZ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001243">
        <property type="protein sequence ID" value="MST34829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="453" mass="46720" checksum="E301D76E9FA77436" modified="2021-04-07" version="1">LPRPEDGAELTAFRADAVAALPGPPGLAARRLAALERLDALAVPDTTAEEWRYSRIGALDLDRYAPATTPSAGALPDAVEAVIAASGAATVVVVTDGLGVEIRRRADGVHVGTDDGEEGAAPGGRSAGDVFGGLNDAFSLPLRIEVAAGARPGGVLVVHWLGGAAGVATFPRTHVVVGARAEVELIELAASAAVDALTVPRTDVEVGDGAIATYLHLQQLGSQVWQIAEQASRVGRDATFSSHAVALGGDYARVRTTSSLVGTGGTTRLLAVYLGTGSRMVDFRTVQEHRAPRTTSELLFKGAVANRSQAVYTGLIRVDKGAAGTNAFQTNRNLVLHQGARADSVPNLEIEDNDVRCSHASAVGPIDEDQRFYLASRGVPPEAADRLITLGFLDEVLQRMAPRALADHVRRRLVASLDEAEAAEEAASAGGGTTGDRAGGPEGPAANPSGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ93</accession>
    <name>A0A7K0JZ93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001278">
        <property type="protein sequence ID" value="MST34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="6101" checksum="FDD782AC48D5F41D" modified="2021-04-07" version="1" fragment="single">MPARVVFDVLLGLHVTCALVGFGSVALTGVYGFLVSGGVGEDDVRRYFASPSRLEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA6</accession>
    <name>A0A7K0JZA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001604">
        <property type="protein sequence ID" value="MST35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="11649" checksum="EE86199901D6CAB0" modified="2021-04-07" version="1" fragment="single">MATEDLEAEQAYIDRAYGQLERMRRRAEGLLGSMKGADPDLEWALARRVRALADNPRALCFGRIDGRDGETWYVGRRHVEDEAADPVVVEWRAPVALPYYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB8</accession>
    <name>A0A7K0JZB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001301">
        <property type="protein sequence ID" value="MST34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041117">
        <property type="entry name" value="SoxA_A3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17806">
        <property type="entry name" value="SO_alpha_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="SO_alpha_A3" evidence="4">
        <location>
            <begin position="447"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="527" mass="54980" checksum="0E180004C1229C0D" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC4</accession>
    <name>A0A7K0JZC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">GHK86_21185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001535">
        <property type="protein sequence ID" value="MST35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="16736" checksum="77FE4036038EA9FC" modified="2021-04-07" version="1">MAETQLTRETYDRLHAELEDLRTRGRVDIARAIEAARALGDLSENGDYHAAKDTQGKMEARIRQLEAMLRDAEIVDAGAAGADGAVRTGAVVSLRYAGDDDVEQYLIGSIEERRPGVSVVSPNSPLGQALIGKRAGDRVAYDAPSGSLEVEIVAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC5</accession>
    <name>A0A7K0JZC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001629">
        <property type="protein sequence ID" value="MST35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="14895" checksum="F3B96F4798ED7FF7" modified="2021-04-07" version="1" fragment="single">MSAAPDVVSRPITVVLVDDHAVTREGTRRILEEHGHFAVVAEVDRGDTAVAAIAAEQPDVVLLDLFLPGASGVEVARELRRRCPSTSVLVLSAFADPEYVDAMLDAGVAGYLPKTARPEQLADAVRAVASGSTVLGAGVAPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZN3</accession>
    <name>A0A7K0JZN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001380">
        <property type="protein sequence ID" value="MST35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="28179" checksum="F7BD79212DDEC7B7" modified="2021-04-07" version="1" fragment="single">MRRGGCAEHGPGERVGRLSPPLGPDPNPLDSPVGGDRRIDAMMIGQLAASSGVPVRTLRFYADAGVLPEAGRTASGYRVFGPDAVARARLVRALRELGVGLDDITRVLAAEASLVDVAAAHARALDAQIRLLRLQRAVLRAFARSADPEELTRMTELTTLTADERRRIVEEYLDAVFGDDPSGVADKLRMGTPELPDDPTPDQVAAWVELAALLRDPDFVAASRRMAQRARAEGPEPDVARFEVGKAVGELAGPAARAGLDPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K069</accession>
    <name>A0A7K0K069_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001507">
        <property type="protein sequence ID" value="MST35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="23173" checksum="E5385C8D6CE92CD5" modified="2021-04-07" version="1">MNLDHRQRGVSRRALAGVEANARLTGGTAVVLLVLLFLEGVTILRILPLLDWHVAIGLVLVPVVVVKLGSTSWRFARYYLGSRGYVAKGPPPPALRLLGPIVVVLTVVLFASGIALLLDPRGLGGRLLFLHKASFVLWFLAMAVHVLGHLAETARLAPRDWMPRTRRSVRGAPARLLLIVASLVVGAALAGALTGRTAHFKQVYFRSPPAAASTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0K3</accession>
    <name>A0A7K0K0K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001596">
        <property type="protein sequence ID" value="MST35299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="65" mass="6798" checksum="C2334EA61DFBBC8F" modified="2021-04-07" version="1" fragment="single">MGKARRSRGGRTTPKGTRPTNFRPGDPWADDPAADEPDLVRQVRAELASGEPLGLLADASGLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0M5</accession>
    <name>A0A7K0K0M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster repair di-iron protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001620">
        <property type="protein sequence ID" value="MST35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019903">
        <property type="entry name" value="RIC_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04405">
        <property type="entry name" value="ScdA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7030" checksum="31B74ACB444A9872" modified="2021-04-07" version="1" fragment="single">MTVTPDATLEQLVLADPGLAAVFDRLGLDFCCHGDRTVAQACATAGVPVAEAIAAVEAAAGTADAADAGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMS1</accession>
    <name>A0A7K0JMS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_00280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="61"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="27135" checksum="E2C39F8AD58D62CF" modified="2021-04-07" version="1">MVRRAARVLAAFSPDRPALSLTELSARSALPLTTTHRLVSSLADAGFLERHADGRYHVGLRLWEIGALAPRELGLREAALPFMEDLYEVTRHNVQLAVREGTESLYVERIAGRRAVRVLTRVGGRFPLHPTGVGRVLLAWVLETVVEAVLAVPLRAYTPCTVTDPEALRQELAAVRARGYAVNDRQVTLDALSVAAPVTSGDGAVVAAVSVVVPAGQHGPEALAPMVQAAARGISRNLPRTTYAPQRKEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW4</accession>
    <name>A0A7K0JMW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03085 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000025">
        <property type="protein sequence ID" value="MST31243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017519">
        <property type="entry name" value="CHP03085"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03085">
        <property type="entry name" value="TIGR03085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="22261" checksum="8B1AFECB609684B3" modified="2021-04-07" version="1">MTTFARDERHALSDLLLEVGPDAPTLCEGWRTRDLAAHLVLRERRPDAAAGILLPPLAGRTAEVQGRLAAGPWPALVDTVRSGPPRPLQPLDEAINTVEFFVHHEDVRRAADGWEPRALSPAMEAALWRRLRTMARLLFRRAGVTVELEATGQGRARGGSGPDTVRVTGPASELVLLGFGRGSHARVAMDGTPSAVERLRQAPLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN44</accession>
    <name>A0A7K0JN44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011102">
        <property type="entry name" value="Sig_transdc_His_kinase_HWE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00911">
        <property type="entry name" value="HWE_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="285"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="490" mass="53471" checksum="5E960BDF028B6D47" modified="2021-04-07" version="1">MATVTDLLHEHTSYSDAVVAHLQRLVATWGTLSDLCFADLLLFVPVSWSAEHFVIVGQVRPTTNRTLHLDDLVGRVVSEQERPLVARGWQLGSVVEGEIDITSRNERARMVCIPVRWQGQLAAVLTRESALSVGRRPGELERTYVEVFDRLARMMANGEFPFPLDEEGETPRVGDGVMVLDAAGRVEFASPNAVNALHRMGLYTSIEGLRLDEVGLAQDSIDVAFAQQLPATQEIIRGPDAALIIRCVPLLDHGSVTGAFVLLHDVTELRRRDRLLMSKDAAIREVHHRVKNNLQTISSLLRLQARRLPAGPGRHALEESERRVRSIAIVHEILSRDTADQVHFNEILPSLVRMAEDLGTSETPVRITTTGDAGNLQAAIATPLAVVVTELLQNAAEHAFPPEAVRADADLRVEVALRRGDTDLSVVVRDNGVGLPPGFSLDRPTSLGLSIVSSLVGTQLGGTIDMRTDGGTVVELTIPLDVVDDDLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN55</accession>
    <name>A0A7K0JN55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">leuA</name>
        <name evidence="5" type="ORF">GHK86_01250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000045">
        <property type="protein sequence ID" value="MST31358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="553" mass="60458" checksum="EDBF9EEECA98ACE8" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN76</accession>
    <name>A0A7K0JN76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000039">
        <property type="protein sequence ID" value="MST31337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="138"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="422" mass="45438" checksum="606546B9830A0A32" modified="2021-04-07" version="1">MSRVVRRRWLSDHSGPSRKDNRGCEYEAYVPDRLVGRAFTIDGEVAADIADAEAAIARLNAEAKSLVDTEALARILLRAESVASSRIEGLEIGARRLLRAEAARGLGDDPTDVTAVEVLGNIDAMVAAVEQVHAGDPITVDLVLGVHRRLLARTRLDRYGGVLRDQQNWIGGSGHNPCSAAFVPPPPEHVAELVADLVAFANEGALPAVAQAAIAHAQFETIHPFVDGNGRTGRALVHLIFRRRGVAPRVLPPVSLVLATCAQDYVDGLSATRYRGPASSRAAHDGTNLWIGRFATACKRAVDDAASFEERARGIEASWRERLGRVRARSAADLLLGALVGAPVVTVNSAADMISRSFVQTNEAISRLVDAGVLQQVTVGRRNRAFEAPDIIAAFTDLERQLASPEGDTHSSEPVRRVPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN84</accession>
    <name>A0A7K0JN84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03842 family LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022315">
        <property type="entry name" value="F420_OxRdatse_CPS4043_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03842">
        <property type="entry name" value="F420_CPS_4043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="37183" checksum="460624B0BB396A2A" modified="2021-04-07" version="1">MDFGVVLQCDPPAWNVVDLARRAELAGFSHAWTFDSHLLWEEPFVVYSQILSATHRLVVGPMVTNPLTRDWTVTASTFATLNEMFGNRTVCGIGRGDSAVRTLNGRPATLKTLREAVGVIRGLANGGEVEHDGVKLRLPWNPASRLPVWVAAYGPKALALAGECADGFILQLADPDITAWSIKAVREAAKAAGRDPATLTICVAAPAYVGDDLDHQRDQCRWFGGMVGNHVADIVARYGAAGADIPRALTDYIAGRQGYDYNEHGRAGNAHTQFVPDSIVDRFCLLGTPDDHIQRLRELRDLGVDQFAIYLQHDGKAATLDAYSEVIIPALRERAAATEAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI7</accession>
    <name>A0A7K0JNI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="366"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="454" mass="49045" checksum="403391DB2E8B123D" modified="2021-04-07" version="1">MLVADIVTIETPGLGDRSYLAHDGDVAVVVDPQRDIDRVTALVEALGVRVTHVFETHLHNDYVTGGLALARQTGAEYVVAAADEVAFERRPVADGDRVSTGRLTVTALHTPGHTPNHMSYALSEDGETVAVFTGGSMLFGAVGRTDLIGEEMTDRLTRAQYRSVRRLATELPEQASVLPTHGFGSFCSASETSGDSSTIGHERRHNIALVTDDEDRFVEELLGGLGAYPRYYAHMGGLNAAGPAAPDLSPPEEVDADELRKRVEAGEWVVDLRQRRAFARLHLAGTVSIELGDSFATYFGWALPWEAPVTLVGDSVEQVAEARRQLARIGVDGIAGAAVGDAEALAGDRRGGYRVAKFADLAEAFDRDDVRVLDVRRRDEWEQGHLAGALHVPFWELPERVDELPGGEIWIHCLSGYRASIAASLVDRAGRTAVLVDDDWARAAELGLPIEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ2</accession>
    <name>A0A7K0JNJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000092">
        <property type="protein sequence ID" value="MST31536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="5884" checksum="C86F0F5532FD500A" modified="2021-04-07" version="1">MELSLDGGVDVDGCPSACVGPAAAEEDQDLAVTQSGFDETAVDALAAASAWQLRPFGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP6</accession>
    <name>A0A7K0JNP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000099">
        <property type="protein sequence ID" value="MST31575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="32447" checksum="EDF149DFB18CDD31" modified="2021-04-07" version="1">MAVLTQERPGTTAAAPARRRSRRRGRSAPPGPWTWVAVAVVVLFVVLPILWMLDSSFKGPGSIGTTDILPHPLSTYNYVTAFGGNGSGDTSGRYILNSVIVAVCTTGLVLILGTLAGYALGRLPMRGKLLLLTVLLMISVFPAIAVIAPLFLIMKSINWLNSYQALILPYTAFNLPFAIWILRNYLMGIPREMEETGRIDGASPLRTLWSIILPQALPGLFTAGIFTFTACWTEFLMALSFNTDNNMRTIPVGLAQFGGQYSVPYGLYFATSCVAAIPIAVLVLVFRKSVVSGLTSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY2</accession>
    <name>A0A7K0JNY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10739" checksum="B191F7BA399683A8" modified="2021-04-07" version="1">MKAAGLRCGDHGGDSGQAKRAASRRAAEAAALAALERARQRDEVRRAALAPYAVALRAAEMAEALDAPEALRQLRAVARALRVTSDEIYHRCRTIEKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP43</accession>
    <name>A0A7K0JP43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligosaccharide flippase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="465" mass="46699" checksum="9CEF022CFF7C8868" modified="2021-04-07" version="1">MEQVRRTGGATLHGGRLGEARRALAPTTLVERARSSPLALGGVAFVGASVAVNLSNFAFHAALSRLLGPAGYGALGSLLNTLVVLSVPLGALEAAVTRMVAARASIGSSAGCRRLSVQAVAVGALGSVVWAGLSPLVQGFLQLHSLWPVLLLGLSIVPMAVGAVWQGVLVGEQRFRTVAVAQVLGSGAARLAMGVLLVSAGLGVSGAVLATVTAGVVTLAVLLPSVRSRLTSADTGALTAGDAAWTIASLGGVATLTSLDTWLGRHFLSPLAAGYFTAAATAGRIALFLPGTIILVFFPGLVKAAGRTAEAHTAIGRALIWVGACALVGVAVLVGASGLVVGVLFGAQFTPAVPVVRVLAAADGMAALISTLVYFQLARRSRLAIAGWAGCVLMAGLAALWHGSTQQLAWTMLAADAATLVTLGAASTLQVRRDRRRLAAGPGPAAAGGRRAATFPALARDRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP65</accession>
    <name>A0A7K0JP65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21382" checksum="9D31959F5C3988D9" modified="2021-04-07" version="1">MDEATSALAAAIGSRVRGERQSRGWTLDRLADEAGVSRRMVVNVEQGTVNPSVGTLLRLSDALGVGLPALVEIPRLRPLKVTRREEGVALWTGERGGRGLLVAGTEPPDVVELWDWTLGSGERHESEAHSAGTTELVQVQQGRLELEVGDESVVLAPGDAVSFSAETGHAYVNPGPRPARFSLVVFEPGVGGAVTRSRQTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP66</accession>
    <name>A0A7K0JP66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="39148" checksum="556A9DD9708171FC" modified="2021-04-07" version="1">MLAVHPGGGLPGGGVPQRLPRHLLRHPLPLPRRAPRRDPGRSRRRSVEQGHVQLRRLPGPRVALGRRPRRPGLPCPGPRGAGRRRRARRSRRGQGRRRPHPLRHGVPPLRRAGRRVTGRLAGRRALVTGAGGAIGRASSLLFAQEGATVAVTDVRPEEVEQTARLVTAHGGRAVVAVADARDGAQVRRAVDHAAAALGGLDLLFNNAGIMPHADRSVLDADADIWQQVHQTNLGGTARFTKHVVPHIVAAGGGSVVNMGSFLAEVGCSHPQDAYAASKGAIAALTRSLAVQLGPQGVRVNALAPGPVLTAHVEQFFPDPAARAVRLGRSPLGRFGTPDDVAELACFLASDAASWITGQTVVIDGGISINYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI6</accession>
    <name>A0A7K0JPI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000157">
        <property type="protein sequence ID" value="MST31868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31600" checksum="478B82383F87EDC1" modified="2021-04-07" version="1">MTDGAGGAATGGIFADRAHREADLGQIGRLLAESHGAPGTGQGCTSSLSLDEVLLLHAVGLEPAAVVTATACTTIPTGSWTWSQGQVQAADYAFSRAFLMTRNQLRAEAARIGAVGVVAVDIELQLAPHRYLVVMLGTAVRAASDEHGQSRFPVRYPTPFLCDLSARDFVVLSRAGWYPIDLVGGASFVHAPRRGMGAALGQVGQNVELTNFTETLYAARELAMERIQQDIREVGGTGLLDMRFVDRPVPFAGHVVRFTAYGTAVKLLADTHSHPELEMVVPLDDRTVRFEASSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR7</accession>
    <name>A0A7K0JPR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliS</name>
        <name evidence="7" type="ORF">GHK86_04235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000177">
        <property type="protein sequence ID" value="MST31935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14408" checksum="C2848E1AE1AE7886" modified="2021-04-07" version="1">MTQWAHQRYLAHQVLTASPERLVTMLYDGIVADLGRASSAIAAGDGYACNEALVRAQSIVLELQRSLRTDVWDGADQLLALYHFLYSRLVVANVKKDAAVVAECLALVQPLQQAWHRAYVAVGESRQAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV3</accession>
    <name>A0A7K0JPV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000187">
        <property type="protein sequence ID" value="MST31975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="681" mass="68637" checksum="39B23E41E4AA7CF4" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV9</accession>
    <name>A0A7K0JPV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000191">
        <property type="protein sequence ID" value="MST31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="24341" checksum="68426488A8E9D53C" modified="2021-04-07" version="1">MVRRLLLWDIDGTLVRAGLLGAEVFDRALEDVLGEVPPGRVRMSGKTDPLIVHEQLALLGLEPDPATVEAVLDRLVARLAEVAHRLPGQGTPCPGVPELLEALGGDPAVASGVLTGNLRPNAEVKLAAFGLDRLVDLRLGAYGSDDIDRNALVPIARKRATEHLGAEVAADDTWVIGDTPRDLECARRGGVRCLLVGTGTYDVSELGSLGADVTLPDLTDTATVLELLAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ61</accession>
    <name>A0A7K0JQ61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Potassium-transporting ATPase subunit KdpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kdpB</name>
        <name evidence="6" type="ORF">GHK86_03040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000119">
        <property type="protein sequence ID" value="MST31704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="453" mass="47424" checksum="FB451EAD5A3472FF" modified="2021-04-07" version="1">IFLVVVVTLAPFSSYSRAAVSVTVLIALLVALIPTTIGGLLSAIGISGMNRLLERNVVALSGRAVEAAGDVNVILLDKTGTLTMGSRQAAAFLPSPGVAEGRLAEAAQLSSLADETPEGRSIVTLAAERYGMAEPSLTGRQVEYVPFSAQTRMSGVDLDGRQIRKGAVDSVARWAGVTIDSDTAATVERISRAGSTPLLVAERGRLLGAVELKDVVKPGIRERLASLRAAGIRTVMITGDNPVTAEVIAREVGVDDFLAEATPERKMEYVKSVRAEGYMVGMVGDGTNDAPALANADVAVAMNTGTMAAREAGNMIDLDSNPTKLIEIVEVGKQILITRGALTTFSVVNDVAKYFAIIPAMFVIAYPGLNALNIMGLTSPQTAILSAIIFNALIIPALIPVALRGVRYTATSAASILRKNLLIYGLGGLVVPFAGIKVIDLVVTALHLVSNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA1</accession>
    <name>A0A7K0JQA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA-disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="128"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="26973" checksum="C1466CFF3C7558F4" modified="2021-04-07" version="1">ATTVRAIRRAPAGAQGRLRVEATDADARPVSWDVDLVLVSVGVRPETALLTAAGAATGAGGAVAVDEGMRTGLPDVFAAGDCVVTHHRLLGVTYLPLGTTAHKQGRVAGENAVGGLARYAGSLGTQVVKVFDVVAARTGLRDHEAAGRWSPATAASAPDDHKAYYPGAHPIAARVTGDAGTGRLLGAQLVGRLGTEVAKRIDVFAAAIHHGMTVAALDELDLSYTPPLGSPWDAVQLAGQAWGRAHRPDLPAPAAGPDPPPRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC8</accession>
    <name>A0A7K0JQC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000226">
        <property type="protein sequence ID" value="MST32158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="28330" checksum="1772F22C1CBB45C6" modified="2021-04-07" version="1">MSENPSTTLRRGVRLLDYLGSVDGDVGVTDIARATGMDKSLASRSLQVLAELGLVEQDPGTRAFRIGWGLFVLAAGAGDRRLRRVAPPLLEELSALTGESAYLSVRDRNEVVTVFAARPPRVIQAVDWTGRRSPLATTSAGRALLFDHDEEAMGRLLAASDFASSLPTGPGDVAELARRVARARRAGVAVVEEEFEPGLVGLAAPVRDWTGAIVAAVNLSGPVFRTRGRKRELAAAVRASAERLGTALGRIGDDRGVDPAQAATAGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI7</accession>
    <name>A0A7K0JQI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000241">
        <property type="protein sequence ID" value="MST32202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17387" checksum="FC7AD6A68BDC1D0E" modified="2021-04-07" version="1">MMHTVPPQSSSGPGGATGAGQRLEPLSLRDTAVQVRAALDLLGDSATQVASRLADAGVTGRRSDQSGCPVARYLHSLGLAEAPVRRLEVTRTHAVLSDGHRWSRRARIELPPGVRAFVAGFDRGQFAQLESAPRPRPSFTGDPVGAQLPSTPDAAGMGERSLVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ0</accession>
    <name>A0A7K0JQJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000228">
        <property type="protein sequence ID" value="MST32167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="458" mass="47681" checksum="229C21EB6E9577DD" modified="2021-04-07" version="1" fragment="single">MTVATPPTSGGPTVCYLTKRFPRLSETFILDEILGLEALGIPLRLFAIADPRERIVQPDVARVGSPVGYLRRGGGAWSRARDLARALGGHARLARRRPRRWVAVVGHVLVARPHRSTLRHLLEAGVMATELQRSGGVHLHAAFANGPASVAHLVSLLTGTPFSFAAHAKDLYLSSPDVLAVKVAAAEFVLACSQSAAEELRRIVGGHHEPAVRASVHKVVLAPHGVDVERFRPAPAGRPPGPVSVVAVGRLVPKKGYPVLLEALEALAGSGAEFSCRIVGDGELRGLVEARLAVTGLSGRVSLLGRRTQQEIVDEYRSAEVFVQASVITPDGDRDGIPNAVLEAMASGLPVVATSVAGIPEVVHHGVNGLLVPPGDAAALAAALGTLIADDLLRARLGAAGRALVEGSWSRTACVAAVARRLMPVTPDGSPLAAVGSPLVHPLGDGGQPLRAVVDGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL3</accession>
    <name>A0A7K0JQL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_05810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000252">
        <property type="protein sequence ID" value="MST32238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="6">
        <location>
            <begin position="307"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="5">
        <location>
            <begin position="447"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="915" mass="96188" checksum="16048D88FA9E9F57" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL9</accession>
    <name>A0A7K0JQL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_05820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000252">
        <property type="protein sequence ID" value="MST32240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="661"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="700" mass="72790" checksum="C96CEC059BE8AEEF" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP4</accession>
    <name>A0A7K0JQP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">fabH</name>
        <name evidence="10" type="ORF">GHK86_05685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="241"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="332" mass="34160" checksum="FE416CF2EFB4E664" modified="2021-04-07" version="1">MTTLGRGAAITGWGSALPPTVVTNADITTLFDTSDEWIVERSGIHRRHQASGPFVADADQPPVHPEDGIGSTAKLAIEAGREALEQAGRSGADIGMLILCTTSPDQAVPATSSAVSAALGIAGGAMDLNAACAGFTYGLVTATGMIGAGLDRVLLVGAETLTRITNFADRSNAFLFGDGAGAVVVEAAPGPGSLLGWDLGVDGTLVPLLYADHGGPGMAMRGQEVFRRAVRVTVESAELSLQRAKVSIDDVKLFVPHQANIRIMDAVADRLGLPRERIASVIDETGNTSSASIPLALVDAARAGRIAEGDLVLLAGFGAGMTWASAVWRWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ4</accession>
    <name>A0A7K0JQQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">GHK86_05745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000249">
        <property type="protein sequence ID" value="MST32227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13490" checksum="37E53E220234B15B" modified="2021-04-07" version="1">MPTIAQLVRKGREQKSDKTKTPALRGAPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGTEITAYIPGVGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGTLDTSGVRDRKQARSRYGAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ7</accession>
    <name>A0A7K0JQQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="420" mass="41335" checksum="EC68C7486B351549" modified="2021-04-07" version="1">MGRSRVAGAPTVAQVETAGRRREGWLLASAGVSILGDRFGELALPVVALEVTHSAWDTAGVAAAVGVPGLVAALVLARRIAAGRSRSVAGAAHMLQALAFAGLSLVVAGTAASLAVLVVFGLAVGVGAALNTAAMPTVVRHCLLDDRRLQRFNGLVEVVDGTATLAGPVLAGVALGALGASPALGIDGLSFALAGLIVLGALRPQPHEPGPEPPRPAAQRAGGLGRLVGDPEQRLLLAVTAAMNLQSGGIVLAVVLLSRRALDTSTLATGAILAAAGLGAIVAGALIVPRVPIEHWQAAVAASFGLCGIGLAALAAAPNLAVAAAANILVDAGSVVCFALTGTRRLQATPPGLLPHLSAVSFQVGSAASVAGVLLVGALAATIGPRWGPAGLAALTILAAAGTTTARTDTRTHPTPDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT1</accession>
    <name>A0A7K0JQT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_06130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000265">
        <property type="protein sequence ID" value="MST32300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21225" checksum="498A31DD8315EE4E" modified="2021-04-07" version="1">MTIRLLLAEDQELIRKALATLLGLECDFEVVATVGRGDEVVAAARSSAPDVALLDIEMPGIDGLAAAAILTEQVPACRSLILTTFGRPGYLRRALDAGARGFVVKDAPAEQLADAIRRVASGQRVVDPALAAETVVHGASPLTARERDVLVACRDAATVAEIAGRLFLSEGTVRNYLSAAIAKTAARNRIEAARIADANGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU4</accession>
    <name>A0A7K0JQU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="25037" checksum="C04F3F5CEED0E47A" modified="2021-04-07" version="1">MVGTLYFRQLLVGRDFADEDPVAAQMLNFAYAVGDRDTGEALLVDPAYAVAELVDLLAADGMRPVGVLATHHHFDHVGGAIAGHQVEGVAELLDLVDVPVHAQRAEVGRIRSATGLDASSVVPHDGGDVVGVGAVEVRLLHTPGHTHGSQCFLVDRLLISGDTLFLDGCGRMDLDDGDPVAMYASLRRLAELPDDTAVLPGHRYSPASSSSLAAVRELNVVFKPRTEADWLAAFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW4</accession>
    <name>A0A7K0JQW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000272">
        <property type="protein sequence ID" value="MST32332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="205" mass="22074" checksum="6AAE8AC0A14D7CCE" modified="2021-04-07" version="1">AVGGPFGSRPEPGFTELGGGEDVAVVFGAVAERRQVRFGYHGEQRLVDPWRLSYRNGHWYLAGLDHGRGEAGEERLFRLDRVEGGVTPAGERHAFDRPTGGAAAPIPTWRLGDDPEVEVRVLVDAEQAPWAVASAGAERVVARHPDGAVELALRVTSRRGLRSWVLGFLDHAEVLGPPEVRDELVGWLEVIAAAPGPAVAGREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY7</accession>
    <name>A0A7K0JQY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="34918" checksum="E6E43546871CB874" modified="2021-04-07" version="1">MAVTARPPLPERPGRRRPRAQWRRIGIALLAAAVLVVVLVRRPERHAPLWLFRTPLAASDPVLPQSATYVHDFVRDYHHAYGAVTVNTMPLAIASPAQAPVPVTVKPGHCANFRSDTGSRIPIPPGTRTSGVGDSPLVVYQPSTGTDWELWQASPTATGWSACWGGKLNTFKSDGVFPDGYGLSGSGISYLATMITEADVASGSIKHAIALDLPACNAPQVFPADRTDCGHDPGQPPEGTWWRFPPGLPVPGGLTPFARMVFHAVQTYGLVFTDQAGAVAIQAQTPVATGHGGRHSADPLTASFEGRQAYQVLDGLPWVRLEAVRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB4</accession>
    <name>A0A7K0JRB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000309">
        <property type="protein sequence ID" value="MST32486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="26228" checksum="E3470FE8993EFAC1" modified="2021-04-07" version="1">MSAAPLEALLGVQDLDTAADQRRHHLEQHPARARLVALGAQRRDLGRRRDEVVARRDEVAGRQAALEAELEATEQRRREVSARLYSGAVSASRDLQAMSAEVDALGVRASQLEDEVLAVLDEREPVDAEVATLEADDARLAAEEDAASAELAAAEAEVGAELEGLHREREEAASGLPADLLATYERLRSRLGGVGAARLVGDRCGGCHLSLPATELDRIRHLPADALVTCDQCGRILVRRATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF1</accession>
    <name>A0A7K0JRF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="25760" checksum="0849DB0976F98AF1" modified="2021-04-07" version="1">MATAVPVYPDLSGKVAVVTGGSRGIGAATVGALARNGAAVAAVARDREALAGVVAAVGEGGGQAAGVVADCTDEDQLARAVEQIHDQLGVIDILAAFAGGDGMPVPTGSETAGHWRHVVDNELTSCFLTVSAVLPDLTASPTAAVITMSSAAARQAARSSAAYAAAKAGVVALTRHLASELAPLKIRVNCIAPSAIENDKMRTWVSAEQRAALAAEFPLGRLGQPDDIANAALFLASQASSWITGVTLDVAGGKIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG7</accession>
    <name>A0A7K0JRG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000234">
        <property type="protein sequence ID" value="MST32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8461" checksum="BFE512A7C5FEF925" modified="2021-04-07" version="1" fragment="single">MNDSRHDRRGPVEPTTAAAGALRPSQRYRVTGGFWAERLEVNREVTIPLGPERLEEAGNLENFRIAAGGGSGPYEGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA6</accession>
    <name>A0A7K0JSA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000294">
        <property type="protein sequence ID" value="MST32449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="26868" checksum="5D04C58AEDD6E2E9" modified="2021-04-07" version="1">MSDELVHLQRRPDGVALVTLDRPKANALSLPLLRQLAAVFEELAADLPGAVVIWGGPRIFAAGADIAGFGGPEEAAVIGREFRVAFDRVAALPRVVLAAVCGYALGGGCELALACDLRIVADTAKLGQPEIQLGIIPGAGGTQRLPRLIGAARAKDLVLTGRHVDADEALRIGLADRVVPADQVLDTALELAAALAAGPLVAQQSAKLAIDLGAEASLADGLDLESRLFVEVFGTEDAREGIRSFLEHGPGRARFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE2</accession>
    <name>A0A7K0JSE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">serS</name>
        <name evidence="11" type="ORF">GHK86_09000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000413">
        <property type="protein sequence ID" value="MST32855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="176"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="426" mass="47425" checksum="5DD97CA35D8D8CAA" modified="2021-04-07" version="1">MIDARLLLDDFDETARRLSRKGVARELVVETRDAALARRAAITATDDARREMNAGSGEVGRLMRAGRKDEAEAKRAELSAFRERIEAMEAERRTAEERFDDLIARLPNLPDDVVPDGRSDADNRVVRVEGYDPAAFEGRQLRPHWEVAEALGIMDSERAAKLSGAMFEVLKGGGARLLRGLVNFGLDLHRDRYQETVVPHMVRTEVIERTGHLTKFDTQAYRLRDDELWLLPTAEVALMGLPQGEILAEDELPKRSMAYSVCWRREAGAAGRDTRGMQRLHEFHKVELVSLCTPETSQDELASLLGDCERTLRTLGLPYRVLELCSGDLTFAASRVFDLEVYAPGLDRWLEVSSVSLITDFQARRGGIRFRRAETGAVELVHSLNGSGLATPRVWAAVVEHGQQPDGTIRVPEALVPYVGADVIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ4</accession>
    <name>A0A7K0JSQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coenzyme F420 hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_09640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045220">
        <property type="entry name" value="FRHB/FDHB/HCAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31332">
        <property type="entry name" value="PTHR31332"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="425" mass="44708" checksum="8A2BB27FF8D913E1" modified="2021-04-07" version="1">MKRYRLREEMNGIPEPPGKVWFWELADGVIDAGRCVQCGTCIAACPSNSIGVSLQTGLPELVKMCTGCSLCWDFCPRGGLRYEALWPPSTPEPAGPQDVTTAGAPAAVSDADAGCRIAGDPGEGLGAVLDRYAVRASPRPGGAQDGGAVTALLAALLAAGEIDGAVVSKPSDDGREPWKGVATVATTPEELVAAAGSFYNQTMALAALDLAAHPGLPPRPRLAVVGTPCEIQGLRAMQARPWSTGAHRVDAVVLTVALLCTKSFDYEALVLRELRDRRNVDLARVGKVDVIRGRMIVEYRDGHVAVDEPVKAFHGAALKGCDECADFLGRGADLSMGSVGSPDGWTSVLVRTDAGRRAFGRARAHFDVRDLPDPAALLRLDGLDKTNARRSLGRDLDPDAPLFIDYADHVRQPSGGASGPVTVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV5</accession>
    <name>A0A7K0JSV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ketol-acid reductoisomerase</fullName>
            <ecNumber evidence="9">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ilvC</name>
        <name evidence="9" type="ORF">GHK86_09890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000459">
        <property type="protein sequence ID" value="MST33028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="7">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="8">
        <location>
            <begin position="205"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="346" mass="38050" checksum="146BC390E5004280" modified="2021-04-07" version="1">MPWPSWQADDPTDRKRDSAVLNQVYRDDDADLRHLSGRTVAVLGYGIQGRAQALCLRDSQVQVLVGTSSSPGQPSWEAAELDGFPVMSIAEATKRADVLDFLVADPAQPTVYEESIGGNLSAGQTLVFGHGFNVLYGLIQPPADVNVTLFVPNGPGHVVREKYLAGSGIYGAVAVEQDATGDAMDVVLAVAKGVGSTRVGVVEVDFCSETEGDNFEEQVLYGGTIALMRATFEVMVEHGYPPYFAYAKAIRSLRSVVDVMDDLGIEEYISRRSSRTCEFAVRMTGPRVVNRAEIERVFEETSRGDFAADWVTEWQRGMMHLHRMRRTGAASQMEQVGREWRDTFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT96</accession>
    <name>A0A7K0JT96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylate kinase-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000379">
        <property type="protein sequence ID" value="MST32749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="27776" checksum="1C1D43BAC6D148BF" modified="2021-04-07" version="1">MPWSTWATIDRLRIRARGSGEALTAPPVWPRTTFPAVSEQFGPVVTISASYGAGGSVIAPRLAEALALPLVDRLLTADVSAEAVGRLDEDPHSEEGLSEGERAASPGSRLFTYLARASGVYGLSAPPLLVEPEEELRQQAEAGLAEIREGGGGVVLGRAGAVVLADRPRTFHVRLDGPPAARARQAALIEGVSEERATERLAQTDRSRELWVRRLYRADPLDPGWYHLWLDTTAFGLDGSVDLLLDAAHRFLGMAPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB2</accession>
    <name>A0A7K0JTB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="36866" checksum="3E7453E16BA210DB" modified="2021-04-07" version="1">MLLEIQKSHRRLADIGWTLWWSGYPVDEGVVRAKLAKLVDVWTTAFELFANTELSEAALTSLKDARLSSKALRWTRQRLGRDDFAPWVRSLIDGLQNGGDGADEADLQRLGSVLGVEEPTSTQSVAETLTAISKVLHPSALREVSQSPLADLAAVRDKAKQFLFIIATFGEISLKTQGRWKPRIGAFSVFLREVAVTPEGQALIVLAWRAMENAGLAEGAPEVLALSDNAERSQREWAAINEIRAMLPPDEAYLVRPKRLGKAQNDPAEHERLRADLLQIRQRWGAEIDAILEAHQLRTVPSLVSAPADPSLAAGRRGAPDSGASPADAAGATPRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB8</accession>
    <name>A0A7K0JTB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000514">
        <property type="protein sequence ID" value="MST33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="19020" checksum="6D518255A3D777DE" modified="2021-04-07" version="1">ALERLEAETRALGGHGVIGIRLRFHYLEGLPSTIEFTALGTAVRREGAGDLARPFTSHLDGQALLKLIQAGMVPVAAAVGVGSVQAEFPRWSMSGSSMELRPFGDAVEMSRRLASDRLVRASRSWGWAVLGTLASISTQGEGEGEVSNTVLTGTVVRRFASGRWDHLPLPVMRLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD0</accession>
    <name>A0A7K0JTD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CinA family nicotinamide mononucleotide deamidase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000522">
        <property type="protein sequence ID" value="MST33206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="33784" checksum="0867C735B6B4EC53" modified="2021-04-07" version="1" fragment="single">MRCEVLAVGTELLLGQVVDTNSAWIGEQLALAGVDSLLAVKVGDNRERIVRALRDALARADAVICCGGLGPTQDDITREAIAEVMGVGLETRPELVEVIRELFAGRGRPMPDNNLRQAQVPAGATVIPQTRGTAPGLICPVGDRVVYAVPGVPHEMRDMLTRAVLPDLTARAGERATIRSRTLRTWGLGESAVAERLAPRLAALDATGNPTIAFLASGIEGIKVRITARGGGSDPAADAEALLAAEEGEVRALLGETVFGVDDETMEAAVGALLLRSGRTLAVAESLTGGLIGARVTAVTGASAWFRGGIVSYASEVKRDLLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD9</accession>
    <name>A0A7K0JTD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000516">
        <property type="protein sequence ID" value="MST33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="96"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="362"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="492" mass="51678" checksum="367AD4DFA0B87A24" modified="2021-04-07" version="1">GRGAGLGALRVPGRRPWARRVLVGLNILIAVALVGGVSAFGYAAYRLSQIHRVSLPGLTAARSGPFTMLVVGSDTRALTGAGNGQFGSKTLNPGQRSDTIMLVRVVPSSRHIELLSIPRDLWVHIPGLGPSKINAAFDRGPSLLVKTIEQDLGIPVNHFVEVNFDSFRQISDAVGGVKVWFPTPARDAYSNLSIPTAGCWSLVGNQALAFVRSRHYTYETNGQWTEQGLSDLARIQRQQVFVKKLFKKAETEFTNPVALNGIIAGVTRNLVVDRGFSPTQMLGLAQDFRTADISGIPTETLPVNNYVVDGQDALSLQQPQAGVMIRQFDTLGDQVAPRTSTRTTPAAGSGASKGGGAPAPSQVAVEVANGSGVTGQAAATAAALARLGYRTTVQQQSPGYGHATTEILYAPDAYADARAVASRLVGATTLLEDATLTPTPYDLEVVTGRDDKGVGPVHAVSTTSTPQAAPTSAGPYFLPGPQPTAAQLAACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP1</accession>
    <name>A0A7K0JTP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD/ThiS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000556">
        <property type="protein sequence ID" value="MST33312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9458" checksum="974A0F8599887E12" modified="2021-04-07" version="1">MVDVRLPTILRPAAGGAATIPAEGDTVGEVFADLVAKHPALRDQVLTPDGDLHRHLNVFLNDDDIRYLGKLDAKVSSADTLTLMPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU1</accession>
    <name>A0A7K0JTU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000440">
        <property type="protein sequence ID" value="MST32949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="19307" checksum="9C72950090BE58B7" modified="2021-04-07" version="1">MFGAAVTGVESGKVSDRVRAASGMAGDGGDRRSWLVVGVDAGSASVGALCTAMDLAGRLGAGIAAVHAIDLRDFPVDPDSDDWGSEAERTLQAQEELVRSVMAGWERHWLYRAVRGEPARVLTGVATQLDALMIVVGARGRRHRHDWGGWADHSIPHRLVGHAERPVLVVPAPVVAGAPAGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX0</accession>
    <name>A0A7K0JTX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">msrA</name>
        <name evidence="6" type="ORF">GHK86_11770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000579">
        <property type="protein sequence ID" value="MST33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="48"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="23673" checksum="981F8ECF153EA835" modified="2021-04-07" version="1">MRFFPRHAVEMVEPGDALPGRDRPLPVPASHFVNFHALQPPFPEGLATAVFALGCFWGAERRFWETPGVWSTAVGYAGGYTPNPTYEEVCSGRTGHAEAVLVVHDPAAVSYDELLAVFWESHDPTQGMRQGNDVGTQYRSAIYVAGDAQRAAAEASRDRYQVALRDAGHGTITTEIAPLGDFYYAEDYHQQYLAKNPGGYCGLGGTGVGCPTGVVPAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ7</accession>
    <name>A0A7K0JTZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000585">
        <property type="protein sequence ID" value="MST33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="17232" checksum="8A69C470337B9C13" modified="2021-04-07" version="1" fragment="single">MPSNVPAPGPRPRRPASSRVRPPPSSRVRPPPSSRVRPPRRRRPQPAGPTPGYGGPVQLRAEPSLVADRPDAVVVAGRALSDEALDAATAALAAELAGAPVVGVDASPTLETVVAVLAALRAGVPVVPLPPDAGPQELGHVLTDSGAAALLVGADRREALAGVVAAAGCGGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU93</accession>
    <name>A0A7K0JU93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000611">
        <property type="protein sequence ID" value="MST33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13885" checksum="C7D434C302A736EC" modified="2021-04-07" version="1" fragment="single">MTAAPVPRYRRPGRATRLANRLVALLTRAGISVLGSRVLETRGRRSGLPRRTPVNLLTLDGAPYLVSPRGETDWVRNVRAAGGSLVLLLGRRRTAYTATELAGDDRLPLLRAYLRRWSFEVGAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD8</accession>
    <name>A0A7K0JUD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="10244" checksum="C3D74515331D2CC1" modified="2021-04-07" version="1" fragment="single">MDIVSALFAENIDLRPVPGPSTRIDLTGIMFSLPAPSEPPVVITPHLIVLIRCRPDEPGEGILEVSFTDEAGEQVARNVSPFTVEPGKFTYRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG5</accession>
    <name>A0A7K0JUG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000647">
        <property type="protein sequence ID" value="MST33581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="23329" checksum="3135422876319231" modified="2021-04-07" version="1" fragment="single">MRTISSTRPADPAPPAAEAYGTASRLPGPSLSGDVVGAAVTGRGSGYWVVNAAGRVFAHGSAGHYGSLPAGVHAGRIVGIAATASGHGYWLVSAGGGVFPFGDARFHGSLAGAHLHSPVVGIAGTADGAGYWLATASGGVFGFGGAAFAGSPNADGLRHHARIVGIAASPGQGYWLAAANGSVYEYGDATFHGSLPSRHRTAEVSAIAATPSGNGYWLAARTGGVYAFGDARFHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH8</accession>
    <name>A0A7K0JUH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_12825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000656">
        <property type="protein sequence ID" value="MST33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="310"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="396" mass="41875" checksum="407C92D06B291D72" modified="2021-04-07" version="1">MTGPTDWVGRVDAETARELLLGTIDAVAAAPALAELAGRVADLVTRSLRVDVCFVHVLDDDERGVTLMGATPPYDAQAGKVHLALDEGVSGWVAARRQPVVIVEGKLDDPRYRYFPELGGLEFVSMASVPMVSRPTGLAGVLNVHSRTRRAFDDGDIALLTGIGQLVAGAVHAARLHRQLLVRRQEYEALVEQALAVQEQERRRIAAEVHDGVAQAVVSLSFHLAAAAEALEEEPRFAAEQVATARRLAELAVAEARAAVDGLRPPMLDDLGLPEALQSLASTSVGEGAEVTCAVAVDPDALPDHVQVAVYRMAQEAMQNVAKHAGATQVLLEVRGGGDELTLRVRDDGAGIEPPPGPGFGPASIRQRAELLGGTLTVTSHPGRGTELLVRLPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ1</accession>
    <name>A0A7K0JUJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_10660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000508">
        <property type="protein sequence ID" value="MST33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="305" mass="33794" checksum="6D32F79F2EA72CC7" modified="2021-04-07" version="1">MGAGPDLLGLYLDEAGSFPLLTKADEMRLGQLIQEGQAAKALLAGPEPVSARRRRELLRQVAAADRATAEFINANLRLVVSVARKYQWSGLPLGDLIQEGNLGLIHAVEKFDWRKGFKFSTYATWWIRQAIGRAIENTAHTVRVPAHVGDEIRRARRLQSELEATNGRPPTLLEVAQAMGMTEAGLAELLRYDSEPMSLDVPVGEDGDTSLGDLVVNQSAESPFESVADSMLPDQIQGFLSRLPEDERQVLWLRYGLDRGEPRTQGEVGEMLNLTAERVRRIERDAIIKLRRHLVGSDAHDLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM4</accession>
    <name>A0A7K0JUM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fliF</name>
        <name evidence="13" type="ORF">GHK86_13095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000673">
        <property type="protein sequence ID" value="MST33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="11">
        <location>
            <begin position="52"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="12">
        <location>
            <begin position="260"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="520" mass="53146" checksum="6A2EAA5D62FF729E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX9</accession>
    <name>A0A7K0JUX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">GHK86_13695</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="WJHE01000716">
        <property type="protein sequence ID" value="MST33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="179"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST33765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="355" mass="36206" checksum="C4EA4586CE5857D8" modified="2021-04-07" version="1">MSSEEPGLTYAAAGVSIDAADAAVEAMRDLVASTQDRPGVLGGIGGFGGLFALPAGYREPVLVSSTDGVGTKLAVAMATGRFETIGIDLVAMCVDDLVCCGAEPLFFLDYQLLGRVDPDQVRAVMTGIAAGCRQAGCAIVGGELAEHPGLLAPGELDLAGFAVGVVERDAVIDGPARCRAGDVLIGLPSPGLRSNGYSLARRALLEAAGRALDGPAWDGAAHTLADELLRPSVVYTPAVLAAVRAVRVHAVAHITGGGLPGNLPRVLPPDLDAVVDLGAWERPRIFGEVQAAGRVSDDEMLRVFNLGLGMVLAVGDGDVDAAVAALRAAGQVPAVVGRLEAGQRQVRVTGVARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY2</accession>
    <name>A0A7K0JUY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="15607" checksum="9CB040791AF962A7" modified="2021-04-07" version="1">MPQDPLEGADRPRPLVVGVAHDPASAAALAFARRLGSSLGAPVRVVHAVDLDDYPVDPDAGTWDAAAPPGSWHVVRGDPAAAIAAEAERLDAAMIVVGAPAHGVGRFGRRSVARRLVEQVGRPVVVVPLPAGVAPDPSADQAGAGTGSGTGLGVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV71</accession>
    <name>A0A7K0JV71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_14200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000753">
        <property type="protein sequence ID" value="MST33865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="323" mass="34151" checksum="8881E5EE11BDAE4C" modified="2021-04-07" version="1">PVRADGCSGGRLGADGARRQRVAGGGVERGDQSGGFRGGRDDVDGNAVGRGLVEGPDVGGDEQHLDEQHADDQEHGPFRDGVGQLVPEALGLVPGHPAPHCSIHSVLDAQRIEIAAGGGVTSVSPPGPRREPTPRRLRTRAALLDAAAALWADRGFWQITVEDVCTAAGFTRGAFYSNFDTLDELFLALWGRRTEAVNTEVARALAAPAGETSIDDLIDAVVGVLPLDRDWARLRAEYLAHAARRPDVAERVAEGRQLLLDAVEAHLDAAIPPLSLPDPLRRPPDAADAILLAVDGVLARLALDGDEAAARRRLVRHLHALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV89</accession>
    <name>A0A7K0JV89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000608">
        <property type="protein sequence ID" value="MST33474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13466" checksum="655245659355C99C" modified="2021-04-07" version="1">MSSAFLPSRVRVVVAEPWAHLRSVLGWVLAHDPRFEVVALLEDGRSAAELPAPYDLALLDLGTSGLEHGTLEQLARRTPPAAAVILAHADVPYLRAAAAARGAAGYLVGPDVLEELPERLAAFGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA8</accession>
    <name>A0A7K0JVA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000765">
        <property type="protein sequence ID" value="MST33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6505" checksum="A30CE42072669292" modified="2021-04-07" version="1">MGETPRPDPERVEARAGDLLPDEAGSADPEAQAAAILADSDERGRDRAGGAVEHRRSGEAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB1</accession>
    <name>A0A7K0JVB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xth</name>
        <name evidence="3" type="ORF">GHK86_12005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000595">
        <property type="protein sequence ID" value="MST33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="28725" checksum="33AA690D5A503655" modified="2021-04-07" version="1">MRLATWNVNSLKARMPRVEEWLAYARPDVLCLQETKLADAAFPQLAFSALGYEAVHHGDGRWNGVAILSRVGVEDVVAGFADGIEADTDTRLVTARCGGVSVTSVYVPNGRSLDSDHYRYKLAWLAKLRRHLDAVAAPDTPVAVCGDFNIAPEDRDVWDPAAFVGSTHVSAPERRALAELESWGLQDAFRGRYPDAEELYTYWDYRAGDFHQHRGMRIDLLLLSAPLAGRVRWALVDRNARKGKQPSDHAPVFVDLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK3</accession>
    <name>A0A7K0JVK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000798">
        <property type="protein sequence ID" value="MST33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8843" checksum="96920B4C7573D5C4" modified="2021-04-07" version="1">MAALVGGAAMMSHRGAVFTLVAAALWVPELRALLLGSMSVTTALTRMAVAVVVAWAAVALVSTVMETYMARNAADRPERRQPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL1</accession>
    <name>A0A7K0JVL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000794">
        <property type="protein sequence ID" value="MST33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="23397" checksum="C65F2A7F1B5B2B26" modified="2021-04-07" version="1">MVSKPSRAKPAVVEEAPPAVDLAEANVGWVIARRVRECRTELGLTVEQLADRSGISKGMLSKIENAQASPSLGTLVKLAVATSVPLTSFFRGLEEEHGAVLVKAGQGLDIVRKGSRAGHHYQSLGGARGAQRIMEPLLVTLTDKSEVFPLFQHGGVEFLYALEGVVEYGFGAERYELHPGDALQFDGGVAHGPTRLVKTPVRFLSIIAHGNLDGGRSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL7</accession>
    <name>A0A7K0JVL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000802">
        <property type="protein sequence ID" value="MST33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15103" checksum="876365294D74AD70" modified="2021-04-07" version="1">MKGVELRCEGGQLTVTLSGWRRLVAVQRGVSVPLTTVVAVEADAAPRARIGVGARPRSSRTPTAGVFRYGAYPGGPGWAFWAIGTGARSVVVELDAGRYRYLVVEVDDPAATVAEIRRASGAAKLAAPQEPGYDSVKLDRGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX3</accession>
    <name>A0A7K0JVX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-deoxy-glucuronate isomerase</fullName>
            <ecNumber evidence="2">5.3.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolB</name>
        <name evidence="2" type="ORF">GHK86_15420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.30" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000852">
        <property type="protein sequence ID" value="MST34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102482">
        <property type="term" value="F:5-deoxy-D-glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04378">
        <property type="entry name" value="myo_inos_iolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="29523" checksum="58929646865804E0" modified="2021-04-07" version="1" fragment="single">MTARLHHPAGSLASGAYDLDLGPEQAGWAYSSLRVLRLAPGGCHPVDTGPDEVLVVPLQGRAAVRCDGEVVDLPGRSSVFAGPCDSAYAPPGAHLEITSPTGGRFALAGARAATGRPFGLVASGSVPVELRGAGSCSREVHNLCLPGVADCERLLVCEVITPAGNWSSYPPHKHDEDGPDETVLEEIYYFELGAGTDGPGVAYQRVYGTAERPIDLLAEVRDGDVVLVPHGWHGPSMAAPGYDLYYLNVMAGPGERACPQRIDRGLLQEPPAGRRAEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW05</accession>
    <name>A0A7K0JW05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000865">
        <property type="protein sequence ID" value="MST34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="30"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="391" mass="43445" checksum="36D73D8F42DC9E74" modified="2021-04-07" version="1">MEFRRINGLPPYVFAVINQLRDEARHAGRDVVDMGFGNPDIPSPEVAVAKLAEAARNPRNHRYSASRGIPKLRLAVADLYRRRFGVELDADREVVTTIGAKEGLSHLMWTLVGPGDTALVPTPSYPIHIYAPLFAGADVQQVRLGPDQDFFGNLVDSWERTWPRPRVIVFSFPHNPTTECVDLAWMARLVDFAREHEVVLVHDFAYADTAFDGFRPPSILEVPGAKDVAVELYTLTKSFSMAGWRVAFLAGNAEIVQALTKLKSYLDYGTFQPIQIASIVAMNEAPEYPREVNAIYRSRRDALCGGLQRIGWPVIPPQGTMFVWAPVPEPYREMGSLEFAKHLVVDADVATSPGVGFGAGGEGFVRFALIENEQRINQAVRSLRRSLTKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW17</accession>
    <name>A0A7K0JW17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000869">
        <property type="protein sequence ID" value="MST34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="235" mass="24617" checksum="B233854969D83795" modified="2021-04-07" version="1" fragment="single">MARRAARVLPRGNSRATLYVPPAAPYAVRGAGAVVTDADGHHVIDANNNYTSLIHGHAHPDVTEAAVRAARDGSAFGLPTGAEVALAERLTARFGRDLRWRFANSGSEAVMMALRAARAFTGRELVVRLAGAYHGTYDQVVAPDEPGVPGPARAATVTVPPDDEVALAEVFRAHGERIAAVLVDLMPNRAGLRPVSAAFAGAVRREADAAGALVVVDEIITYRLGLAGLQADYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ7</accession>
    <name>A0A7K0JWZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgA</name>
        <name evidence="5" type="ORF">GHK86_17315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001023">
        <property type="protein sequence ID" value="MST34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="194"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="311" mass="33169" checksum="DF7A42B44163575A" modified="2021-04-07" version="1" fragment="single">MRVTLLTREYPPEVYGGAGVHVVELARALQGLVEVRVGCFGRPRPDPLVTAAVEPWSALPPTPEGAALRALSADLVLAAAAEGSDVVHSHTWYANLGGLLAKRLWGIPHVVTCHSLEPLRPWKVEQLRGGYAVSGWAERAALEDADAVVAVSSGMRDDVLAVYPAVDPDRVRVIHNGIDPGRWAPDPGTSAVERLGIDPSRPYVMWIGRVTRQKGITHLLDAASRIDPAAALVLCAGAADTPELADEVAAAVERLRAERDGVHWIEGMLPQPEVAQLLTHAAVFVCPSTYEPFGLINLEAMACEVPVVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX10</accession>
    <name>A0A7K0JX10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001029">
        <property type="protein sequence ID" value="MST34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32479:SF17">
        <property type="entry name" value="PTHR32479:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="162"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="28529" checksum="A3F786970E5A2D4B" modified="2021-04-07" version="1">VAQRAGLVPARLGLPRLPLRQPVQRPTPHPPGDDVWLFTGCVMDAWQRDVHLAAQGVLEAAGFGVRPTGDEAPCCGALHQHAGLSDRTRALAATVMAALPGPAPVLVDSAGCGAALKDYGRLLGTPEANAFSARVYDIQEWLAAHRDRLPEVAAGDRLRRRVAVQDPCHLRHVQRVHQATRVVLAPYVDELVELDDEGLCCGAGGAYSALQPDLAGQIRDRKVAAIERVSPDVVASANPGCSMHLAAAGVVTAHPMTLVWEALRHARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX15</accession>
    <name>A0A7K0JX15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001039">
        <property type="protein sequence ID" value="MST34498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14386" checksum="25301B12D1090423" modified="2021-04-07" version="1">VAGLAAGGELAVVDPAEVADRGPYDVVLELVGAPNLPADLAALATGGRIAVIGTGAGSRAELDLGLLMRKRGRIHGSTLRARPLEAKAAAARAVEAHALPHLATGRMRVPVCATFPLEDAAAAYERFTSGSKFGKVVLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX47</accession>
    <name>A0A7K0JX47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar motor switch protein FliN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliN</name>
        <name evidence="8" type="ORF">GHK86_17590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001053">
        <property type="protein sequence ID" value="MST34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="7">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="10805" checksum="1A891176133545DF" modified="2021-04-07" version="1">MVVGVQLDGRVAAPDLPPLDAGTAAAGPARSLASLSDVAMGVTVELGRTTLTVRDLLGLHTGAVIQLDQEVGTAAEIFVNGTHIGSGEVVVVDGDYGIRVTRLVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX81</accession>
    <name>A0A7K0JX81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000871">
        <property type="protein sequence ID" value="MST34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="15443" checksum="5C0744C5C6CB3E4A" modified="2021-04-07" version="1" fragment="single">HVDTPLLVHAIPDRWRHHLAVASAADYFFDTRLKAATFAFLLNAVPIERQRVDRSSARRLSALIEEGWSLLIYPEGGRTPDGWGQPHQRGPAWLAERTDRPIVPIHVTGTRRILPRHATRPRPGHTSVSFGRPLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB7</accession>
    <name>A0A7K0JXB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001090">
        <property type="protein sequence ID" value="MST34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="15634" checksum="27EBAE1A7D251D57" modified="2021-04-07" version="1">EPPAVPGPDACAPLTGDRLPQVHGRYDLRLPADSPWFDGPAGDEPFEVTGWIRFADGAPPSALALLAFADAFPPTVLNTLDVGWVPTIELTVHVRGRPAPGWVLGTFRTRFLVDGLLEEDGELWGEDGRLLAHARQLALILPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD4</accession>
    <name>A0A7K0JXD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001094">
        <property type="protein sequence ID" value="MST34606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="43996" checksum="BB2AB15D1FE77F7A" modified="2021-04-07" version="1">MTTETDTEVRLTSYEDCRDGYRHQGFRQALYDDGVVLMSDVIVNLHGDAHRARRRLENRLFRRDVFLRWERELVPAAILDALSSSLAEGRADLVPLARRAMMTIAAAIAGVDRPEGTDEEFDDLYGVMTRLSRASTVVHATGDKEAIKADGLAALAHFERRFFAPSVARRRDLLARHGSGLLEICPDVLATLLVNQERLELGPETVLREVAYFPWVGSHSTSNALAHTMAHTLSWLEDHPGDRHRLESDPEVVQRFSHEALRLHPPSPVALRRALTDVTLGSGREVPAGAHVVIDVVAANRDPSIFGPSADAFDPWRPLPEGVNLWGLAFGTGFHSCLGQELAGGVASSPGDPASEVLRGSIATMASILLRHGARLDPADPPTLDHQTVRKHFGRFPVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG7</accession>
    <name>A0A7K0JXG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_18205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001124">
        <property type="protein sequence ID" value="MST34648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="11">
        <location>
            <begin position="254"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="9">
        <location>
            <begin position="348"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="360" mass="39180" checksum="A8FD9504242F0D05" modified="2021-04-07" version="1" fragment="single">MVQVGPHGRPGYRRPPPVPGPAPGGAGGCGTLPPGTALPFGCADAAPRARPRAGNRWFRPAPLMSQLRLDPLTGRWVVIAAERLERPSAFQTRRLPVEDDPNRPCPFCPGGDEAEAPSLEVYGPDGTWQVRIVPNRYPAFSGADPMVVSHLGPVFTQAPAGGIHEVFVITPEHEATWADLSDEQASLVMYALRDRMAEHSSIPGLRYSQAVVNRGREAGASIEHPHGQLMSMPFVPGETANEMAGFARFQGNCLLCAVADAEEDVRHRLVAADDQVVVVSPFWSGSPYEMLIIPRHHGPHLYEATDEDLSAMGRAVRVALRALRGRLGDVAYNLMFHSAPYRVTGVHHWHIHVVPQVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ8</accession>
    <name>A0A7K0JXQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001141">
        <property type="protein sequence ID" value="MST34672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="65"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21177" checksum="C4EFA33630AF7186" modified="2021-04-07" version="1">MATDAPVTPAASRPLPIWVWLPVGLAVALGVGFGAWFATRPRNTTPSPFGASSLNAGSQTTGLPRLTGQVAPGFHLPSLRGGSPVALAAHQPTVLNFFASWCHGCRQEIDAFGATWKADRGKVDFVGVDTGETSPATARKMLAQAGATYPVGLDASSTVTGRYQILALPTTIFINRSGRVAGEVFGPQTRQDLARWIHKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV4</accession>
    <name>A0A7K0JXV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001210">
        <property type="protein sequence ID" value="MST34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="126" mass="12430" checksum="394EED78EDD51755" modified="2021-04-07" version="1" fragment="single">MKVAIFGLGYVGTVTAACLATHGHEVWGVEIDPGKVALVDAGRSPIVEPGLDDLVGAAVRAGALHATGDTAAALDGADVSLICVATPSSAQAGTDLSHLDAVTASLAAALRAGDADPGRRHVVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY35</accession>
    <name>A0A7K0JY35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001272">
        <property type="protein sequence ID" value="MST34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="30042" checksum="BAF32751602F8A0C" modified="2021-04-07" version="1">PDRADRPPAVPAPAPPRRAGTAIGAPHVVGVVAVCRLLGYVAPSPKTLRQVLGGSYADFVQLAAERHGDGWGMAWPEGGGVAIRKEPRSAAEAGAFAETADRLATGAALVHLRWATLDLGVSLVNTHPFGDGRLAFAHNGSISEMPPLEALIGDTRAEPAGDTDSERYWLTVQAAVERTGDPVRGLAEAVLTLDRTCQFSSLNCLLLTPTELVAACWWRPEQRSPEVGPDYYDLAYHQEGGATVVASSGWHDPGWTPLPNGALLVLDRDGGQPRVEQVRSLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY54</accession>
    <name>A0A7K0JY54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001270">
        <property type="protein sequence ID" value="MST34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="224" mass="23787" checksum="DF374B5DEE4B48E7" modified="2021-04-07" version="1" fragment="single">MIVAEHLTKSYGATRAVDDLSFTVAPGRVTGFLGPNGAGKTTTMRMILGLDMPTSGRATINGRLYRDLPAPLTEVGALLEAKALQGGRTARAHLEVLALSNGLPKRRVLEVLRLVGLEQVAGRRIGNFSLGMSQRLGVAAALLGDPHTLLFDEPVNGLDPEGIQWIRQLMQGLASEGRTVLVSSHLMSEMALTAEHLLVIGRGRLIADAGIDEVIRAGSKQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA3</accession>
    <name>A0A7K0JYA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_19590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001299">
        <property type="protein sequence ID" value="MST34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="356" mass="38202" checksum="D292516F4CB43228" modified="2021-04-07" version="1" fragment="single">MPDVSFGATVELRDLQRSFGSTRALDHLSLTLEPGELVALLGPSGCGKTTALRVLAGFERLDGGTVSVDGTEISGVPAQKRGMGMVFQSYSLFPNMHALDNVAYGLRMRRTAPAERRRRAMALLDMVGLADRAKQYPHQLSGGQQQRVALARALAIEPRVLLLDEPLSALDAQVRLQLREQIRGLQQRLGTTTLFVTHDQEEALSIADRVCVMREGRIEQVDAPAVLYKRPATPFVAEFVGTMNRLPARIAGAAVEVLGRRAAGGSADGRFPDGAAVDVLVRPEGLTLRRDEGGRGILTARTFLGSVTRLTVLLDGEPAASVKVDAPSDEAAALELGSPVTVELVDDVVMVVEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA9</accession>
    <name>A0A7K0JYA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nadE</name>
        <name evidence="7" type="ORF">GHK86_19365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001269">
        <property type="protein sequence ID" value="MST34872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="32254" checksum="4202017858962C89" modified="2021-04-07" version="1">RATERPSGWSVVARGPRGLGAEEEIYRALVVGTRDYVRKNGFADVVVGLSGGIDSSLVAVVAADALGTDHVHTVAMPSRYSSEHSLTDAAELARRLGVDHRVIPIEPAHAAFAAMLADSFAGRAEDLTEENLQSRIRGVTLMALSNKFGWLVLTTGNKSELAVGYSTLYGDTAGGFAVIRDVPKTLVYRLCRWRNTTGGVIPSGVLAKPPSAELRPDQRDDQSLPPYEVLDPILEAYVEDDRTAAELVAAGFDAATVARVVRLVDTAEYKRRQSPPGVRVTPKAFGKDRRVPITNRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB6</accession>
    <name>A0A7K0JYB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_17550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001050">
        <property type="protein sequence ID" value="MST34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029674447" evidence="6">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="21644" checksum="10981648C273068D" modified="2021-04-07" version="1" fragment="single">MVLAARLAMSVGRAVASVVTALYLAAVGFSAIEIGALFVGVTAASAVMASTIGLLSDRWGRRPFLVVVPLMTAAAGAVFAFAHTPVVLFAAAALGSFGRGAGAGAGNIGPYQPAESALVADTVPGDQRSAAFGRIAFASSLGALGGGLLAGLVHVRGHMTAAAATAAYRPAFLAAAGLALVAGLLALLLREPHRRPAPALGQCYWLIRAERHPLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC3</accession>
    <name>A0A7K0JYC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001321">
        <property type="protein sequence ID" value="MST34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="192"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="32305" checksum="AAB0507C8BAE37E0" modified="2021-04-07" version="1">MSGPATAADVVLGAGPDPVGAGTGVEVTASRETQVGAFRVRRALPLRARRTVGAWCFVDHLGPAAVTEDHGLDIGPHPHIGLQTVTWLLQGEALHRDSLGSEQVIRPGQLNLMTAGRGVAHAEEATGRYHGDLHGVQLWVAQPDGTRDGPAGFEHHAELPRVELSAAQATVLVGELAGARSPARRDTDHVGVDLDLRRGTTAVPLRPDSEYGLVVLAGAVAVDGVHLGPGRLAYLGAGRDEVALAATAPARALLLGGVPFDDPLVMWWNYVARTRDEIVEAHRAWEAGDHRFGVVDSPLARITVGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC6</accession>
    <name>A0A7K0JYC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_17600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001054">
        <property type="protein sequence ID" value="MST34529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="243" mass="27062" checksum="A033844C567F6DAE" modified="2021-04-07" version="1">MPFSAVPATLGGVRVLVVDDEPAVRQALDRALRFEGFETELAEDGNVALMAHAQKPADAIVLDVAMPRLDGLEVCKRLRSAGDATPILLLTARAAVSERVAGLDAGADDYLVKPFALEELLARIRALLRRSAPAADEEVLHFDDLTLDPGTRDVFRGSRRIELTRTEFLLLELFLRNPRQVLPREVIFDRVWGYDFGANSNSLEVYVGYLRRKTEAEGERRLIHTVRGVGYVMRLPIEDRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE4</accession>
    <name>A0A7K0JYE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001342">
        <property type="protein sequence ID" value="MST34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="8992" checksum="145E2FD8F424F8A5" modified="2021-04-07" version="1" fragment="single">MTTPASPGQGAPAQDRLEVLLGPGSVIRFGRVAAWAAPTASLALLSFLHQSVRNVGPSARGGQLLADHIAGILAQRDPEPATAFAAVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK4</accession>
    <name>A0A7K0JYK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="9" type="ORF">GHK86_19815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001329">
        <property type="protein sequence ID" value="MST34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="367" mass="40646" checksum="D2DD794A6379F8C3" modified="2021-04-07" version="1" fragment="single">MSKVLSSLPVHERVGIAFSGGLDTSVAVAWMRHHGAVPYAYTADLGQYDEPDIGSVPGRALEYGAERSRLVDCRRQLVDEGLAAIACGAFHIRSGGKVYFNTTPLGRAVAGTLLVRAMQDDGVSIWGDGSTFKGNDIERFYRYGLLANPQLRIYKPWLDAAFVAELGGRKEMSEWLAERGLPYRDSPEKAYSTDANILGATHEAKRLEHLDTSVEIVEPIMGVAHWRPEVRIEPEDVTVAFDKGRPTAIDGRSFDDPVELFEEANAIGGRHGLGVSDQIENRIIEAKSRGIYEAPGMALLHLAYERLVNAIHNEDTVAAYHNEGRRLGRLLYEGRWFDPQAMMLRESLLRWVGSAVSGEVTVRLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ3</accession>
    <name>A0A7K0JYQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrroloquinoline quinone biosynthesis protein PqqB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001415">
        <property type="protein sequence ID" value="MST35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="5906" checksum="4B278521AF5B5D2B" modified="2021-04-07" version="1" fragment="single">MADQAPPTTPAAGPGDRRALVVMTVAHGIQHFYVAGLALTYPFVVADLHVSYAVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW2</accession>
    <name>A0A7K0JYW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GHK86_20370</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01001409">
        <property type="protein sequence ID" value="MST35072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MST35072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="7510" checksum="32CD8C44FC601288" modified="2021-04-07" version="1">AFLGGGVAGSALAAAVGAVAGAALAVWARGAPAAAGIGAAVIAAAAVLSLARRRLGGFTGDVLGAAVVVSETAALLVSGVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ7</accession>
    <name>A0A7K0JYZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001206">
        <property type="protein sequence ID" value="MST34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="19978" checksum="E6839CED6220952D" modified="2021-04-07" version="1">MEPSVSELDLIRWSEALAGIARTGLGFTDSLYERERYEEILRVAADIRVAATDGSPSTPEVVDAWLASVGRGVTGYVTPKVAVGAVVGNDRGEILLLQRGDSGMWLYPTGWADIGYSPAEVAVKEVLEETGIEAEPVRLIGVLDGQRFGSRGLPFYSVVFHLRAVGGDLAPHSRSPANRRPPGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ07</accession>
    <name>A0A7K0JZ07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Citrate synthase/methylcitrate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001501">
        <property type="protein sequence ID" value="MST35188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9272" checksum="C22BC93E39FB2F71" modified="2021-04-07" version="1" fragment="single">MTTASPADSLIDVPPGLKGVAVTATGIGDVRGSEGFYHYRQYAATELARHRSLEDVWQLVLDGHLPADADERGAFAREVGPLRALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ64</accession>
    <name>A0A7K0JZ64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001565">
        <property type="protein sequence ID" value="MST35265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="46" mass="4816" checksum="ED6FE3B2EBB6CB1E" modified="2021-04-07" version="1" fragment="single">MSYDRWVSDAVQVVEGVGAATLVVGGVVVAAQFAAHAVARRPDAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ75</accession>
    <name>A0A7K0JZ75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M16_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001267">
        <property type="protein sequence ID" value="MST34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="17169" checksum="2B8028E4771EE780" modified="2021-04-07" version="1">MESILDHILGSGMSSRLFQTVREERGLAYSVYSYRQAYEHAGALVVYAGTAPDKAREVLGLVHDELDRMAADGITAAELEGARGHLRGSLVLGLEDSGSRMSRVGHALLTHGRVPSVEELEERFAAVTLDDVAELAAEVLGGPRSVAVVGPFPDEEIAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ77</accession>
    <name>A0A7K0JZ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001505">
        <property type="protein sequence ID" value="MST35192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="10207" checksum="4975D54495A0044B" modified="2021-04-07" version="1" fragment="single">ADDHLAGPGGTPLGPLHGLPVVHKDLQDTAGVRTTYGSPLYAAHVPAASSPLVVRVAAAGAISLGKSNTPEFGAGSHTYNPVFGPTRNPWDPTRSAGGSSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE0</accession>
    <name>A0A7K0JZE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001567">
        <property type="protein sequence ID" value="MST35268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="446" mass="48556" checksum="F39844C5477B9A1F" modified="2021-04-07" version="1" fragment="single">MTVAFDLGGLLEERAGDREHLHDEHLNGKLAQVLRTIGFDRNYTSGAGCYLYDDEGRDYLDFLAGFGVYALGRSHPVVKQALHDALEADLPNLVQMDCSLLPGLLGEALVKRSHAGIRRVFFCNSGTEAVEGAIKFARRATGRTRILYCDHAYHGLSTGSLALNGGKEFRNGFGPLLPGCDPVPLGDLAALERELAAGDVAAFVFEPIQGKGVYEAADEYWVEAEAACRRHGTLVVADEVQTGLGRTGRFFCHDHWALRPDIITVSKALSGGYVPVGAVLTTEAVWDKVYRSLDAALVHSSTFGSNALAMVAGLATLQVFDDEDIVDRARRTGDLLVKALQPLVDRYELLHEVRGKGLMVGLQFGRPTSRGLRLRWDALERVRAGMFSQLVVVPLFDRHRVLTQVAADGVNIVKLLPPLIAGEEEVDRFVGALEDVLDDAHKGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE1</accession>
    <name>A0A7K0JZE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnpA</name>
        <name evidence="5" type="ORF">GHK86_19750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001320">
        <property type="protein sequence ID" value="MST34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6629" checksum="0B22C98FFFB7BA8E" modified="2021-04-07" version="1" fragment="single">MIWRVERRELFLALRSARRGRSGPLTVAYLPGDAAEPPRVAFAVGRKVGGAVVRNRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE5</accession>
    <name>A0A7K0JZE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001552">
        <property type="protein sequence ID" value="MST35252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="19960" checksum="4AB5E1AA99218D82" modified="2021-04-07" version="1">MSGHRGPRVEGDRRAARAAEPRAPALWQTGRVPLLLVRHAHAGSRKEWSGDDRLRPLSTRGRHQADLLGGLLEPYAPQRILSSPYLRCVATLEPLADRLSLRVEPLEELAEGNGPLALGLVRALADEKVVLCTHGDVIPEVLVALADEDRVDLGPSPRQAKGSTWVLEASDGRFARAVYLPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZL0</accession>
    <name>A0A7K0JZL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001643">
        <property type="protein sequence ID" value="MST35338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="276" mass="28314" checksum="4A893AD478A95E6D" modified="2021-04-07" version="1" fragment="single">GDGGGGTADGRRSLWVLALVTLALAGASAAQMALLYHPGFDPSRVYDGTDTRAFGLLFGAALAMVWPSRALSVRIAPRARVLLDAAGAAGLLGIGVLMWRTTQYSPFLYPDGMVLLSLATLAVVAAAAHPATWLGRALGWKPLRWVGSRSYAIYLWHYPIIVLTDPGASARPSALRDLAQVAASLVLAELSWRLVESPVRRAGRAGDSLDRLRVRPVTGIGRRPGLVLSAVAGVVVVGLAAVAALPGIASHPATSAAVGGSGPAPVTPTATTAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K018</accession>
    <name>A0A7K0K018_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001479">
        <property type="protein sequence ID" value="MST35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="14630" checksum="23FCDC7992F5C3E7" modified="2021-04-07" version="1" fragment="single">MATVRVRSAEDAGPLILDTLDSSWKGCKAVSKRLASTGRWNLGAAAAVLAALTGTTILATVTTDPAVWARCLVGVAALTAALLVGVQTWSTRQREELQALRRQLHELHHEIEIKLDDFMRGKPLPDGYGIEVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K030</accession>
    <name>A0A7K0K030_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001473">
        <property type="protein sequence ID" value="MST35154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16078" checksum="E2E8919CBE86689E" modified="2021-04-07" version="1" fragment="single">ADPRRSGALAARSLVSAGAYGMFFFLVQYLQDVHGYSPLEAGVAFLPIPAAIFASSQLTTRVLVERLPGRLLLLGGLALALGGMVVDSMLTPASGYGRLLASMLLFGVGNGVSFVLLTNTGISGVAPGDAAAASGLLNVTQQLGAALGVAILVSIFGAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0H6</accession>
    <name>A0A7K0K0H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001592">
        <property type="protein sequence ID" value="MST35294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14597" checksum="9006DAF58F48F3DE" modified="2021-04-07" version="1" fragment="single">MSGGLRILVADDQRVVREGLATLLGTLPGVEIVGLAADGHEAVALVAERRPDVVLMDLRMPGMDGVEATEVIRRDHPDTRVVVLTTFADDASVLTALGAGAVGYLTKDATRDDIRRAVEAAGAGQAVLDASARQTLLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0N7</accession>
    <name>A0A7K0K0N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR02680 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001633">
        <property type="protein sequence ID" value="MST35329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="330" mass="35829" checksum="E4325DF2DDA5E188" modified="2021-04-07" version="1" fragment="single">GDVPGGAPEPVAAEPVALARAVLDAVPAGDGVSDQVVLNRLHDLEEGLAGGYDVVAGEDDGVKYFRVVDDTGRQPLPAVARRVAAEADAAARRLDASEQEVIRRFLLGELGDELRDRLLEAHDLVASANQALAGQRTSHGIGAHLEWKIDPEAAPTARTTAELLVRQPRTAGEEAQLRDALLEMIRAEREQDPAVGYLDHLRAALDYRNWHRFSVQVVDDAKPGVKRALHGRLGLSQGEQRVVSYLALFAAAAAYYEGIGAGCPRLLLLDDAFAKVDEPTHGRLLRLLIDLDLDFMITSERMWGCFREVPSLEIYEALREPAVPGVALVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0Q3</accession>
    <name>A0A7K0K0Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protoporphyrinogen oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001644">
        <property type="protein sequence ID" value="MST35339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="20027" checksum="D56403F5717930D4" modified="2021-04-07" version="1" fragment="single">PLRVEPVAATGVAPVAGGGVTVDGVGRFDGVVLAVPAAVATGLLGPLAPPGLAAIRTTSVTLVTMAWDEAAITAPPGVNGVLVPPGEGQLMTACSFGSSKWPHWVSPGRVVLRVSVGRQGDRRAEELTDGQLVDRLAAELREALGARGEPVAARVSRWPGAFPHYAVGHLGLVAGIRAELRRRAPGVTLAGSGYDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMD6</accession>
    <name>A0A7K0JMD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="PTHR10632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="403" mass="44246" checksum="6C86D5196FF31E27" modified="2021-04-07" version="1">MSAVRKRHRVVIVGGGSAGITVAARLRRAGEDDVAVIEPAEVHYYQPLWTLVGGGRAPVGRSARPEAAVMPAGVSWVKDRATEIDPDAQTVATAASGRIGYDYLVVCPGLALDWDRLPGASETLGHGGVSSNYSVDLAPRTWDFIRRTRQGTAVFTMPSGPIKCAGAPQKIAYLAADWWRREGVLGDIRLVLVLPTPAMFGVPEFSTVLEGVADRYGIEVLLQHEVTEIDPDRREVVVSDRSAGQDRKFTIGYDFAHLVPPQSAPGWIKSGPLADPDSAWGYVDIDKETMRHRRHPNIFSLGDAGSSPNSKTGAAIRKQAPVVVGNLRAVMAGREPTMRYDGYASCPLTTARNRMLLAEFDYTMKPRPTFPVIDTQKERYDMWLVKRYGLPFLYWNLMLRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMG9</accession>
    <name>A0A7K0JMG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000010">
        <property type="protein sequence ID" value="MST31156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="467" mass="52602" checksum="BB421366B4B53ACB" modified="2021-04-07" version="1">MVADRGDEFERDVWDLRRLRLHHQRCPRTIRFDDIPQDWLREAVKRWIRLRLGRWAATTVVGNSVHLRAFAAFVALRHPEVQGPGALTRAVLEDYMLYVARPPGEVPPTKALSSLGIFLDDCRRHEWLALADSARIYRDDFPRKPLPLPRALDESVMAALEHPDNIVQLPDDGTRCLVVVMMRTGLRAGDLVTLPFDPLVFDHNGAPFLRFFMGKMRKDHRLPVDDVVAGAVRAQQDLVRFRFPGGSPWLFPRLRLNTDGRAHYSTATIGARLRAWTGRCAITDATGAPVKVTTHQFRHTLGTRMINQGVPQHVVQEILGHESPSMTAHYARLHDSTLRAAFDAYSAARVDITGRVVSYDPAGEMADGQWMKERLARARQTLPNGYCGRPLQHECPHPNACLTCPDFLTDAGFLDAHRDQLGRTRTLIATARANGQFRMVEINSVIATNLERMVTTLESLEEGGRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMK5</accession>
    <name>A0A7K0JMK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilT/PilU family type 4a pilus ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="413" mass="45197" checksum="6C2E25B44423F214" modified="2021-04-07" version="1">MVEVQEAIVREIEETTNWPIVPLLIAESDFRSLLRDLYGQAAAKVLQSEESEEQAEPEPLHLNALLEEMVALSASDLHLSAGLPPSVRIDGAIRPLPDRDALNASELRQLIFGILPQRDQERFERELELDASHTVPDVGRFRLNVFQQRDAVGAVLRAIPFKIVPLPDLGLPPAVASLAELPRGLVLVTGPTGSGKSTTLASLVDIINSTRPCHIMTVEDPIEFLHRSKKAVVNQREVGSDTRSFADALKRVLRQDPDVILIGELRDLETISTALTAAETGHLVFATLHTQDAPQSVDRIIDVFPPHQQQQVRVQLASTLQGVVTQQLLPRARTRGRAVACEVLVTTPAVRNLIREGKNHQIYSAMQAGGQYGMQTMDASLGALVRDGVISLEVALEHCHNQSDLRRLAGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMT5</accession>
    <name>A0A7K0JMT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000018">
        <property type="protein sequence ID" value="MST31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="8317" checksum="8A4A402A37BE990D" modified="2021-04-07" version="1">MKVWIDQDLCTGDGLCEEIAPAVFTLLDDGLSYVKEGDKVFDNPGGHDGLAVVPDGMDEAVREAVEECPGECIFIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX6</accession>
    <name>A0A7K0JMX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="407" mass="44158" checksum="AEE2C6E2B574B0DD" modified="2021-04-07" version="1">MPTPRPASDPTRGSASPAARGAGEPVQSLDALLAAKEIVIACGSGGVGKTTTAAAAAAMAAVHHGGRVLVVTVDPARRLANALGLPGFGNDARRVPSEAFAAAGVEPRGELWAAMLDTKQSWDALVRRHAPDAGTERRILENPLYQNIAGRFVQSHDYIAMERLYELHSEGRYDLIVVDTPPTRNAVDFIEAPQRMAEFFSSRLLRLLIVPYRSRMVNLASRPFYQIADRILGSQFLSDIAEFFILFQTMYGGFVERARAVERLLRDRRTTFVVVSTLEAAPVHEAEFFIQVLRAKRFHLGALVLNRVLPGYLLDPAAGVAATRLVAHADVVAEGLAPLLGAEPAQLGRVLREVGDTYRNLRVVAKAEAAQRDDLAAVPEVVATAPELEADIHDLTGLLRLGQLIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMZ4</accession>
    <name>A0A7K0JMZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000025">
        <property type="protein sequence ID" value="MST31247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="24731" checksum="7C008A5671EC230C" modified="2021-04-07" version="1" fragment="single">MTDPSHGFVELADGVWLHTSERGMTTTTVVALDGERCLLVDPAMEPHDLAAVADWLAATDRRVAFGWSTHAHWDHVLWSSRFGRDVPRFATQANVATCSAELPELHGYIDHQCPGHEVELCGLLTPVRAAGLLWPAAWEVAEHRAHAPGHALLWLADRGVLIAGDMVSDIEIPTLDLDQADPLGDYRRALDLIEAYADRAAVFIPGHGRAGDGTELRCRLELDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN16</accession>
    <name>A0A7K0JN16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000041">
        <property type="protein sequence ID" value="MST31345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="145" mass="16584" checksum="0C225AD0D7BEE6BD" modified="2021-04-07" version="1">RLWKATAWEPPDERRARTGTRMQAAPLLIVPLCSEAAYRTRYAAADKAWIPDDDKWSTPYWYVDAAFATMLVLLKAVDLGLGALFMGTVPRFVPRFREAFGVPEDFEPIGVVLVGHRHPEVPPNYRADRRRPAEEMVFRGRWGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN64</accession>
    <name>A0A7K0JN64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K(+)-transporting ATPase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdpF</name>
        <name evidence="2" type="ORF">GHK86_00905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000032">
        <property type="protein sequence ID" value="MST31291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="29" mass="3189" checksum="6617C9EFE5C8185A" modified="2021-04-07" version="1">MSAAEAILLAISVALFLYVGYAMIKPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN66</accession>
    <name>A0A7K0JN66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000061">
        <property type="protein sequence ID" value="MST31406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="48603" checksum="DF431FD70332526D" modified="2021-04-07" version="1">MTRRPSASRGGDAGGDQRQRTSRSRRAERSFDVTTRNKTVLGGVALAAGISLLAGACGSSSGSAAQSSGSGNSAGTAASSGSGSAVPAANKKTITMLFGSSGPAETAAENQAGKAFTKKTGIPVKVVAAANLTQELEQDFAGSQPPNLFYLSPTLFQQYVSKGVLDAYGQSLPNVNDFYPSLKSAFTYKGKLVCDPKDGGPLSLYINTADWRAAGLTSADYPTTWAQLASDAKKLTTKKRVGLTMDPNESRMDAFLYQAGGSVFNTSQTKVTLDSSANVKALGFLKGMLKAGSLAFPSALNEAGGTDAFGAGKAAMVVTGNWLEGTMTADYPKVKYTIQPLPAGPAGKNTTLTFTNCWGVPRSNDNLGGTIEFVKFLTSPAQELRFAKEFGPVPSLQTVKAQYLKAFPQNKAVLAGLSSGVPDISLAGSTQALTAYNSALAELATTSPSSILRAAQTNLQAVLTQDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH5</accession>
    <name>A0A7K0JNH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000079">
        <property type="protein sequence ID" value="MST31488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8178" checksum="A2F9827C54A6604F" modified="2021-04-07" version="1">MAGVVKSVAIQPRDGIQVLTCTLEDETGGISLVFSRGRVDGVEPSARLVAEGMVGEYDGSLAIRNPTFELLATATEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY9</accession>
    <name>A0A7K0JNY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000117">
        <property type="protein sequence ID" value="MST31690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="50"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="449" mass="46278" checksum="A178886827F05A30" modified="2021-04-07" version="1">MGVIIRGGTVVAPEGALAADVRVVDGVISAVGEDLPAEGSDEVVDAAGCYVLPGGVDPHCHVMADLPAASRAAALGGTTTLLSFTSPGEDEPPAPGVRAARRLVEEGGSMVDVGLHAACYRPDELTGADVEEVARLGADAIKVFLAYPELGIMASGGGLLRAMTHAARVGLPVQVHGEDGEIIEALVERAAAAGRRDLPVFAEVRPAVTEELAVDRVLAIADLTGARCYLPHLSTEGAVEAVRRRRAGGTGPAAVTAEVCVHHALLDDGEYQVPAGEGFLVAPPLRPRRHVEAVARALADGTIDAVGSDHSQHPTPVDGRIASSASASYGIPGIGARLPLFLSWGQARGIPVERMAHLLATGPARAFGYGTKGALAPGMDGDIVVWDPAARWTITADAFPDGTGRAPYAGRPVTGRIRFVCGRGRVLVRDGEPVDARPEGRLAPRGPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP47</accession>
    <name>A0A7K0JP47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YdcF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000111">
        <property type="protein sequence ID" value="MST31667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="21934" checksum="2DC41FCBE2D3C7B5" modified="2021-04-07" version="1">TAWRVLGGLTAAGVVYVAVGFAQVWWAAHVDQARRVQAIVVLGSAQYDGVPSPDLAARLTHALALWRRGLAPVIVCTGGKEPTDLFTEAETEANWLAARGVPRDQLLPVVEGRDTWESLAAVARVLQSRNIRRVLYVSDPFHDQRLRMMSGELHLTPFVSPTRTSPIKGAALVPYYAKETLEVAVGRIIGFRRLSQITAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP94</accession>
    <name>A0A7K0JP94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000121">
        <property type="protein sequence ID" value="MST31711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019278">
        <property type="entry name" value="DICT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
        <property type="entry name" value="DICT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="43834" checksum="21F3289477C03DAC" modified="2021-04-07" version="1">MALVERVLDQRRITPAFQPLVHLVSGEVVGFEALARGPEGTAVHTPDALFGLAEQLGRLGELDWVCRAAALEQALASGLDPSFSWFVNVEPSGLATPCPEDLRPALAAGRRLRVVLEMTEREVDRDPARLLRATAAARRSRWGVAVDDVGAVPRSLALLPFVQPDVVKLDMSLVHSLDRAETAAVANAVRAYAERTGAVILAEGIETEADEMRARVLGAGYGQGWRYGRPGPLPRSLAPPQHPFCFGQVLDPDTGRTPFEIGAGSRPVGRTSKGLLVPMSLHLERQALAGGEALVLLASFQEARHLTAGTCARYAELAHRNVLTVAMAAGLDAVAGADGVRAVDLAAGDPLLAEWNVIVVGPHFAGALLARDLGDGGDDRQRRFDYLITHDRELVIRAARAMLRRITEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD5</accession>
    <name>A0A7K0JPD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4328 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000150">
        <property type="protein sequence ID" value="MST31826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025565">
        <property type="entry name" value="DUF4328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14219">
        <property type="entry name" value="DUF4328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="3">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4328" evidence="4">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="293" mass="32158" checksum="D4871E36A9B06587" modified="2021-04-07" version="1">MSFRSPPFPAPHSAVRSDAAMAPAARKPPVGWYPDPAGAPEWRWWDGYRWTEYTHANSPGWYPRGMGDRDGVDEPATWQQNEAALFPWARWAVLVTMAVDALGTVEGFADRNVLLRFHRYLQQGLAQAGGPGYLPPLPPHFPAGYRLIQLLGLVVVAGNVIFLLWQYRAARTARALRYRARHGPGWGVGAWFVPVVNLWIPYQSLADCLPPAHPVRRGLVWLPLAYFLGLPAASLAWEVAAFFGVGWAPLLVPAAVSVALAGFVGWRGWRFVTAVHRDHEASVVAQPAGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL0</accession>
    <name>A0A7K0JPL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="530" mass="54893" checksum="FC003A06EAC33384" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU6</accession>
    <name>A0A7K0JPU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000176">
        <property type="protein sequence ID" value="MST31931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="115"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="515" mass="55893" checksum="DF2907635BE21C3D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW5</accession>
    <name>A0A7K0JPW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exo-alpha-sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000184">
        <property type="protein sequence ID" value="MST31951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="40150" checksum="8F4EB26A46724540" modified="2021-04-07" version="1">MAGVRVLVGTAKGAFVLEADGTRRDWTVTGPLFGGWEIYHVTGSPVDPDRLWASQTSGWFGQQVQRSDDGGRSWKPVGNDFRYAGSTGTHLWYDGTPRPWSFTRVWHLEPSATDPDTLLAGAEDAALFRSVDGGGTWEELSGLRTHRSGPAWQPGAGGLCVHTVLVDPTDPDRLHVAISAAGVFRSADGGASWEPANQGLLQPGIPDEDAEVGACVHRIARHPSRPDTLFMQKHWDVMRSDDAGGSWHEVSGDLPSDFGFPIAVHAHEPETVYVVPITSDAEHYPPEGRLRVYRSRSGGNEWEPLTRGLPQSDCYVNVLRDAMAVDGLDPCGLYFGTTGGQVYASADGGDSWEAAVRDLPRVLSVEVQTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY6</accession>
    <name>A0A7K0JPY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GHK86_04665</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="264"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MST32018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="405" mass="43072" checksum="566E7ECFFFED5A41" modified="2021-04-07" version="1">MSLVVQKFGGTSVADAERMRIVADSVARTVRRGHQVVVAVSAMGKETDELLHLATEVSKVRPGRELDMLITAGERKAMALLCMALHDLGIPADSFTGSQAGILTDTDHTRAKIVEIRPDRIRKALDAGRVPVVGGAQGVSSDKDVTFLGRGGTDTTAVALAHALHADACEIYTDVSGVFTADPRAVPEARRIKRVSFEEMLEMCAAGCPKPAMRSVEFARTYGVPLHVRSAFTWEPGTWIDEEDPEVEQAIVSAVVSDSSQAKLTVTGVPDRPGIAARLFRVLADRSINVDMIEQNVSIHGTTDISFTVAHEDLEAATAVVAELEGDIGATGSTSDPDIATVSIVGAGMKTQPGVTATMFETLAAEGINIEMISTSSIRLTCVVRADVVERAVQSLHRAFELEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ72</accession>
    <name>A0A7K0JQ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000211">
        <property type="protein sequence ID" value="MST32096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15078" checksum="2DBF2A980DB0CF70" modified="2021-04-07" version="1">MEADPAGPPRPRHPAARLRPRGATTTSSATATPDRPASPSAGELITVADVEAERLLTRRSTDLPPAAVVGEEACAEDPTLLAGLRSALAWLVDPLDGTTSFVEDDPAWAVMVALCVQGRAVAAWIWQPTSPMYTAEAGGGAPPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ90</accession>
    <name>A0A7K0JQ90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P) transhydrogenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000209">
        <property type="protein sequence ID" value="MST32083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="3">
        <location>
            <begin position="152"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="389" mass="38753" checksum="FC6679644FE110E1" modified="2021-04-07" version="1">MGVDAVTVRVVVAREAAAGERRVALTPDVVGRLQAAGLDLVVEAGAGVAAGFPDADYEKAGATVVPAGSGLGHAEVLAAVGLPDVSGLRAGQVVVGLLQPLLRPQLMEELAGRGVTVVSLDGLPRTLSRAQSMDALSSQANAAGYKAVLVATEHFARYLPLLITAAGTSKPAEVLVLGAGVAGLQAIGTARRLGAVVRAYDVRPAAKGEVQSLGAQFVELTSVGPAAGEGGYARALSAEEQAAQQAELAGHIARHDIVITTAQVPGRRPPELVTADAVAAMRPGSVLVDMGASELGGNVAGSRPGEVVVTPGGVTIVGAGDLASRLATSASAAYARNLTALLGHLVADGELHVDLDDEITAGVVVAHGGAVVHPATAALLHPQPSEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ93</accession>
    <name>A0A7K0JQ93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ORF">GHK86_05035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000210">
        <property type="protein sequence ID" value="MST32091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="15077" checksum="3F2471C9F48D5871" modified="2021-04-07" version="1">MAAALAAARAAGDHGDVPIGAVVARGGEVIATGGNERELQADPTAHAEILALRRAAAALGTWRLTDCTVYATLEPCPMCAGALVAARVERVVFATFDPKAGACGSLYNLCVDPRLNHELAVESGVAAEEAAALLRGWFTTRRAAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ7</accession>
    <name>A0A7K0JQJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">acpP</name>
        <name evidence="5" type="ORF">GHK86_05680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8766" checksum="B365D3FEBC6A0F90" modified="2021-04-07" version="1">MDNAEAFDKFKQCAVEVLQVEPDKVTPEARFADDLDADSLDLVELVMALEEQFGISVDESELEGVETVDQAFKLVTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK8</accession>
    <name>A0A7K0JQK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000251">
        <property type="protein sequence ID" value="MST32235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="70"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="287"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="369" mass="37915" checksum="F134D1832DF14D81" modified="2021-04-07" version="1">MPDLIAIDLPAGPAWVELLRRAWDAGDAVLPVDQRLAPPAKRAVLAALGAGVVVDAGGRATLPGGRPVEPGDALVMATSGTTGEPKGVVLTHDAVLASARATAARLGVDPAVHRWLACLPLNHIGGLSVLTKALCTGSALTVLPGFDAEAVLAASGPEVLVSLVPTALRRVGSAAFHTVVLGGSAPPAGLAANVHTTYGLTETGSGVVYDGRPLDGVDVALDDADGQIRVRGPMLLRAYRDGRVPLDDAGWFATGDAGRWVDDRLVVDGRLSDLIVTGGENVWPTPIERILATHPAVGEVAVAGRPDEEWGERVVAFVVPAAGSEPPTLDALRGLVREQLAAFAAPRELVVVEALPKTAIGKVQRALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL7</accession>
    <name>A0A7K0JQL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3492 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3492" evidence="3">
        <location>
            <begin position="62"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="379"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="606" mass="66257" checksum="6978E1A3B9E57FBD" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN2</accession>
    <name>A0A7K0JQN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_05635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000245">
        <property type="protein sequence ID" value="MST32207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="349"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="620" mass="64136" checksum="C093E114E3C4A623" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN3</accession>
    <name>A0A7K0JQN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_05910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000258">
        <property type="protein sequence ID" value="MST32258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="879"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119464" checksum="8A62227E79A64A8A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR6</accession>
    <name>A0A7K0JQR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000261">
        <property type="protein sequence ID" value="MST32276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="536"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="630" mass="67505" checksum="923DF0D11C5330C5" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV8</accession>
    <name>A0A7K0JQV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="74"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17938" checksum="3CF1CFCF18E7F75E" modified="2021-04-07" version="1">MDPSLYPGGYRWRPHQVHGGDGGGRRTRRFGSRRRSGTVARTGYPPGYPGDRESVFRRSQVVREVDVRTFAAAHADGALVIDVRESFEYAAGHVPGARLVPLGALPGAARDLPRDRPVYVICASGNRSLTAAGRLSQMGFDARSVAGGTAGWTQSGLPVVRGTHENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR66</accession>
    <name>A0A7K0JR66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000292">
        <property type="protein sequence ID" value="MST32438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="11382" checksum="AA622FBDE80E2893" modified="2021-04-07" version="1" fragment="single">MTAWDIAGTPAHVPYPAVWDGSLWTLEFEDACYLLVAALAAACLLRRRRVVLGPWAGSWAATPGLAAVAVPTWTDANLHDPLRFVPIFFAGVVLGPVPGPGPRPPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR79</accession>
    <name>A0A7K0JR79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000290">
        <property type="protein sequence ID" value="MST32432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="28561" checksum="355CAF11D1539737" modified="2021-04-07" version="1">MTVLVGTSGWHYAHWRDRFYPHGCPSGRWLEWYATRYPTVEINATFYRLTAEATLRSWRDTVPDGFVFAVKASRYLTHVRRLKDPREPVELFLERTAALGDRRGPILLQLPPDLHAEPDRLEETLRCFGPSVRVAVEVRHPSWDRQDVRELLSAHGAALCLADRRGHLAPEWRTADWGYVRFHAGRASPWPHYGRQALTTWAGEVARWWPEGDVYAYFNNDQEAVAPGDARDFARRCRRAGLEVAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE5</accession>
    <name>A0A7K0JRE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplW</name>
        <name evidence="7" type="ORF">GHK86_07245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000315">
        <property type="protein sequence ID" value="MST32516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="11208" checksum="CC8A1A1419CB4805" modified="2021-04-07" version="1">MVSGDPRSVIIRPVVSEKSYALQEHNVYTFVVAPGANKIQIRQAVESIFNVRVEAVRTLNRQGKRKRSRRQPTFGKRPDTKRAMVTLREGDSIPLFEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF0</accession>
    <name>A0A7K0JRF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplB</name>
        <name evidence="7" type="ORF">GHK86_07240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000315">
        <property type="protein sequence ID" value="MST32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="30388" checksum="12A2C9B96FA0FCAA" modified="2021-04-07" version="1">MPLRKRKPTSAGRRFQTVSDFAEITKTRPEKSLLAPKPGSGGRNSYGRKTARHRGGGHKQQYRIVDFKRTKDGVPASVAAIEYDPNRNARIALLHYHDGEKRYILAPARVKVGDVLQSGQGAEIRPGNALPMRYIPVGSVVHNVELKPGGGGKIARGAGMSVQLVAKEGDYATLRLPSTEMRRVPIDCRATLGEVGNAEAELVKVGKAGRNRWKGVRPQTRGVAMNPVDHPLGGGEGKTSGGRHPVSPWGKPEGRTRDRTKPSEKLIVRRRRTRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK0</accession>
    <name>A0A7K0JRK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANTAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000325">
        <property type="protein sequence ID" value="MST32543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="2">
        <location>
            <begin position="286"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="353" mass="38574" checksum="64A0CEDEC2C88686" modified="2021-04-07" version="1">MALIASDGPPPTALRRPPRPSSGRRGTPSSRSPDQWADRPSPARHHPTTTDTPGSRKTQYLVYGISCGATLAAFSASAPERTKTVQKPKRKPRPGARRRRRSRPGSGYTPLSCSEEGVVPQFPGYERASTFQAADTPLLVVDTDLVVRDINPACLDATQRRRDEVLGIPLAEAFPDNPDDEGSTRIRELGDAFETVFRTATRHHLPIHRHDVPSRDDPTRFVRKDWISVTTRLLDEAGRVVGALHHAEDVTTVAAHLPAAPPEGLHLDAGTWSALLVTLAIETRGHERALHTARELQRALDSRVVIEQAKGLIAGRSGVGVDEAFTRLRQHARRNNTGIHEIAHAVVELGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR7</accession>
    <name>A0A7K0JRR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000348">
        <property type="protein sequence ID" value="MST32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="62" mass="6605" checksum="E39C4C77C104C3A2" modified="2021-04-07" version="1">MHARNSKVWRGPFTGVEGARLALVRLAETAEVFAESGADLPARLVSQVADDIAELLVAGEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT8</accession>
    <name>A0A7K0JRT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_07940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="674" mass="71511" checksum="E6D3145A278958D0" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW3</accession>
    <name>A0A7K0JRW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_06200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000268">
        <property type="protein sequence ID" value="MST32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="25982" checksum="04C4F7829F233A75" modified="2021-04-07" version="1">PGPTSHGWSLEQVVPTSGPSTPATAATIAQLRDRLPAGSLVGGAAAENVDLQHALAQRTPVVFGMLAGLGFLLLLVALGAPLVALGGVVVTSLSVAGAFGVARLIFQDGYLSRLLHFTPQGFVDAWAPLFFGAMVFGVAMDYTLFLLSAAKERYETHADPEHSMVGSVQTSGRVVVSAAVVMVAVFLTFALSGPLAPKEMGVILAVAVALDAIVVRLVLLPVLLRLAGHAAWHQPVWLGRLLPEVRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS69</accession>
    <name>A0A7K0JS69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_06705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000287">
        <property type="protein sequence ID" value="MST32409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="8">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="449" mass="50177" checksum="D0097C31343EB78B" modified="2021-04-07" version="1" fragment="single">MASRIIRKVNAEMDERLGTQSFLKDAFDHIFPDNWSFMLGELAMYCFIILVVTGVYLAMFFDPSDTVVTYKGPYMPMHGVKMPVAYETMIQINLQVRGGILFRQMHHWAALLFLGAIIMHLARLFFTGAFRKPRDLNWTIGATLLLLSMLNGFTGYSLPDDLLSGLGLRIFYTILQSVPVAGNWLSYLVFGGQYPSSQITHRLYIVHVFVIPLLIAGLIGAHLAVIWRQKHTVFPGEGRSERKLVGSQMWPVYTFRSTALFFFTIGLIAILAGTTQINPVWLYGPYEPWSASSFAQPDSYVGWLIGALRLFPKWQLHLFGYTVADVFWPGFVFPMVAVGFLYAYPLIERLWTSDLLLHNVLDRPRDRPGRTGFGVAVIVFFGLLTLAGAEDVLAHFLQTSQTVVMLATRGACIVAPPVAGLFTWKMCKDLSTAPAQPSEPPEGPASSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH8</accession>
    <name>A0A7K0JSH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vitamin K epoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_09115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000417">
        <property type="protein sequence ID" value="MST32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="15932" checksum="8DA659F183C15EE4" modified="2021-04-07" version="1">MRTPRWASAVGLAICVIGVGIASYLTAVHYAGITPVCPAGAGSIINCGQVVTSQWSTIFGVPVPVLGLVFFVGMLPLQLPAAWRSNSPLIRVARLGGTVVGVGMILWLIYAELFLVGKICLWCTSVHVLTFILFCTTLFGTLATTPEPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM0</accession>
    <name>A0A7K0JSM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:acceptor oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000436">
        <property type="protein sequence ID" value="MST32932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="18920" checksum="D71F39D9F11256DD" modified="2021-04-07" version="1">MFQVRIHGRGGQGVVTAAEMLSVAAFVDGRHAQAFPSFGSERMGAPVTAFARLDELPIRSHDPVTAPDAVVVQDPTLFADTSLLDGLAALGLLLVNTVRPPGDLPVSLAPGRRLVTVPATEIARRTVGRPVPNTALLGALAALTGVVTVGGLEAAVRRRFPPPLADANVRALREAAALSAGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM4</accession>
    <name>A0A7K0JSM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000437">
        <property type="protein sequence ID" value="MST32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="49" mass="5402" checksum="5958941970FE3681" modified="2021-04-07" version="1">ATTDKPAVRRRAVLALAPFEGPEVDAALRQALEDRDWQVRQAAEDLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV1</accession>
    <name>A0A7K0JSV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000451">
        <property type="protein sequence ID" value="MST33007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="34398" checksum="F5B67C0B935C33A2" modified="2021-04-07" version="1" fragment="single">MGIRVRIAALFAALVAVLVTIGAVGFAVDFSGGLHRSLESALRARAERIIHDARGGHVDDPVGQVFAKAVADAGQSVTQLLGRNGAVLVTTAAAGPSPLVTKGAVRAASIRDRYVEERLPRQGGRWLLLVTAWPAGGGVLVTGRPLDTLDDAVARARVDALAAAALAVVLAAVAGWSITGWALRPVERLRAGAAAIVDNDLGEDLPVPPTGDELAALAATLNALIARWRQILMQQRELVSAASHELRTPLAALHTQLELARRSSSGDGELDEALDRALNRSRRLARLATDLLTLAETDEGVPLRFGPHVPVEPVVAGVLEDWRARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT81</accession>
    <name>A0A7K0JT81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10756" checksum="8264095F9AB8007D" modified="2021-04-07" version="1">MALPDHVRHAQRRIAVLDGVYRRALLGLEAAQERKAEVLADADRHVRAARDRAEQAVAEMARQLSVPLTAELVDLPVREVRRIARAHPAPGDGRSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA3</accession>
    <name>A0A7K0JTA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000500">
        <property type="protein sequence ID" value="MST33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029729173" evidence="2">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="3">
        <location>
            <begin position="81"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="15946" checksum="97846AD10C1364F0" modified="2021-04-07" version="1">MRRSPIVIAATLAGVAGVLTFHTKKPATIVSAPASGSSSTTTPPATSAPASGSGSTSGAGSSTTAPAGGTRSATGKTIPYGYGELAVKVTVNGSKITNLKIVTLATAEAYSQQLAQQVIPMLQHEVMQAQSARIQGIAGATYTSEAYAQSVQAALDTLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC4</accession>
    <name>A0A7K0JTC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">GHK86_10665</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000508">
        <property type="protein sequence ID" value="MST33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="4"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="326"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="234"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="462" mass="50972" checksum="568C1D6C80BEF15F" modified="2021-04-07" version="1">MAPRVRIAPSPTGYFHVGTARTSLFNWLFARQQGGTFVLRIEDTDRARNQPEQIAGIQRALRWLGLGWDEGPYLQSERFERHVAVIERLLAQGAAYACDCRPEEIDARAKARGGPPGYDGHCRDRGLEPGPGRAVRFRTPSEGDSVFDDVVIGGPVREPLRVVGDFVIRKANGDPLFILANVVDDADMAISHVIRGNDHLSNTHKYVLVWEALELGPRPVFAHLPLMVNAAGKKLSKRRDKVAVEDYRDEGYLPEAFCNYLALVGWSPGGDREILPLEEMVAAFRLEDVNKSNGVFDERKLLDVNKKYLMALPTDDLVARAGSWLAERVAPLAPLVQERSRTLAEVWSMVDFVYQASPVVDADAWERSRRRVPAFGAILAGVIERYTTIDWTADAIRQATVDAGEAAGVASLAKAQEPVRLAVTGRTVGPPLFESLQVLGRDKTVARLQAGLSRLPEPTAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD2</accession>
    <name>A0A7K0JTD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000517">
        <property type="protein sequence ID" value="MST33198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="1">
        <location>
            <begin position="43"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="205" mass="21992" checksum="18C188B0A1655F52" modified="2021-04-07" version="1" fragment="single">MAMATSVLGAGEQEATGSELGSWLVAQACGACSWEAGWLAALARFDRARQWTTDGALSCADWLIGRVRLARSTAFEKLRVAHELARRPLVAAAFAAGEITYCAVREITRATGTDPATDETLVELARTATVLDVRRAVRRVLLLAEQDREPVERQSNRGVRIVANGDGTTRVHAVLSDLEAAELAAALDTLMDHSSGVSQSEESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL5</accession>
    <name>A0A7K0JTL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nusB</name>
        <name evidence="8" type="ORF">GHK86_09075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000415">
        <property type="protein sequence ID" value="MST32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="14255" checksum="A81DFEDE11D263B3" modified="2021-04-07" version="1">MAVAGVRRQARERALGLLYEAEVKEHAPSGVVADLPVTPDPYAVALVEGVEAHAAEIDRLLAAHAIGWSVDRMPAVDRSLLRLATFELLGRPDTPTGVVISEAVDLAKEYSTEESGRFINGVLSSVAGVLRPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM8</accession>
    <name>A0A7K0JTM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_11220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000547">
        <property type="protein sequence ID" value="MST33287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="55"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20356" checksum="C821C55E6A417947" modified="2021-04-07" version="1">MVGLLVVAAGVPVSLGVLVLVGGPVLAFLVVEQRLAHASERWQQQVGRELPVVAEQLATLLNAGFSLGAAVNRLAARGHGCCATDLRVVANRVRQGVAEVAALEEWADLVAVDAVRRLVRVLALHTEAPDLGRLVSAEARQVRRDLQRRTVEQMERRGEQVWIPVSVAALVPGAILLAVPVLAALRLFANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV2</accession>
    <name>A0A7K0JTV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000573">
        <property type="protein sequence ID" value="MST33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="62" mass="6950" checksum="39D5FA02644AD085" modified="2021-04-07" version="1">MPRYRFTTSGADTTDEADFAGDDDAQAHARDRSRTEGVVVTVHRHSGHVDAWEYVGEADERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW3</accession>
    <name>A0A7K0JTW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 4 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_11570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4 5"/>
    <dbReference type="EMBL" id="WJHE01000571">
        <property type="protein sequence ID" value="MST33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="9744" checksum="00E1E60ECCA17CEF" modified="2021-04-07" version="1">MSELVRRGVVVRGVVQGVGFRAACAREARRLGVAGWVRNRDDGSVEADLQGVPAAVDRLLAWCRVGPAGARVDGVEVHPGVPEPGLTGFRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY0</accession>
    <name>A0A7K0JTY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_11835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000581">
        <property type="protein sequence ID" value="MST33405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="52"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="411" mass="42016" checksum="3BBEACAD8FF43B2F" modified="2021-04-07" version="1">LHACAWCFGPLEVVYDYEAVAAAVSRESIAAGPPSMWRYGALLPADAAGAVSLGAGFTPLVRADRLAAELGLGELWIKNDALNPTGSFKDRVVSVALSRARELGFKVAACASTGNLANSVAAHAARAGMRSVVCVPADLEPAKIAASAIYGGEVVAVEGNYDEVNRLCGELAGEHPDWAFVNVNLRTYYAEGSRTLAFETAEQLGWQAPDHVVVPVGSGSQLTRIARGFRELHAVGLLDELPEVRVSGAQAAGCSPVAAAFASGSDTVRPVRPHTVAKSIAIGDPADGVYALDAVRSAGGGFGSVTDEEIVEGIRLLARTEGIFTETAGGVTIASLAQLAASGVVRPDERVVAYVTGNGLKTLDALAGEAAGEGRGGGAPAGRGGVGPTVTITPTLAAFETAIRSLEEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ4</accession>
    <name>A0A7K0JTZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein 2</fullName>
            <ecNumber evidence="5">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mrdA</name>
        <name evidence="5" type="ORF">GHK86_11865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000583">
        <property type="protein sequence ID" value="MST33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="57"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="283"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="640" mass="67524" checksum="33D8F5CA1CB95181" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU17</accession>
    <name>A0A7K0JU17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Malate synthase</fullName>
            <ecNumber evidence="1 2">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aceB</name>
        <name evidence="3" type="ORF">GHK86_11995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="1 2"/>
    <dbReference type="EMBL" id="WJHE01000594">
        <property type="protein sequence ID" value="MST33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="320" mass="36223" checksum="C9FD425139A502B9" modified="2021-04-07" version="1" fragment="single">MAESIPHGLQERILTPEASRLLGELHRRFEGRRQALLAARDERQERFDGGERPRFLPATAAIRRERWHVPEAPKPLADRRVEITGPTDRKMMINALNSGARVFMADLEDANAPTWANMLTGQANLQDAVRRTIELATPERTYRLVDEPATLVVRPRGWHLTERHFTVDGEPISASLFDFGLYLFHNGREALSRGFGPYFYLPKLEGHEEARLWEEVISAAEGLCGLDHGSVRVTVLIETITAAFEMDEILYELRDHICGLNAGRWDYIFSIAKKFHADPAFVLPDRSAVTMTVPFMRAYTELLVRTCHRRGAHAIGGMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC6</accession>
    <name>A0A7K0JUC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsK</name>
        <name evidence="9" type="ORF">GHK86_10360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000491">
        <property type="protein sequence ID" value="MST33119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14279" checksum="F77D892C7400FFDD" modified="2021-04-07" version="1">MAKPKPGGRRPRRRERKNVTYGVAHIKSSFNNTIVSISDPEGNVLAWASAGNVGFKGSRKSTPFAAQLAAEQCARRAMEHGVRKVDVLVKGPGSGRETAIRSLQATGIEVAGIKDVTPIPHNGCRPKKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF6</accession>
    <name>A0A7K0JUF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000648">
        <property type="protein sequence ID" value="MST33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="719" mass="75056" checksum="0A442CF933442991" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK9</accession>
    <name>A0A7K0JUK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000661">
        <property type="protein sequence ID" value="MST33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="27453" checksum="D867D2C9A9CD6194" modified="2021-04-07" version="1">MRLEVAGRRLEVAEFAGTEAAGPPLVLLHEGLGCVRLWRDWPQRLAAATGRRVIAYSRAGYGASDPVDLPRPLRYMHHEALAVLPPLLERLEVDRPVLVGHSDGASIALIHAGSAGRPVAGLVLLAPHVFVEERTLAGIRAARRAYLDGDLRPRLARYHDDVDNAFWGWNDAWLDPAFAAWNIEDVLAGLACPCLVVQGAEDPYGTPAQIEAIRRGSAAGVESHLLAGCGHAPHAERPAETSALVLAWLAGGRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM1</accession>
    <name>A0A7K0JUM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000676">
        <property type="protein sequence ID" value="MST33655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16805" checksum="9FA88AC82B298687" modified="2021-04-07" version="1" fragment="single">MRVDHAALVRGWREGGECCEIDGVGPVPVATVQAMMSDAFLAAVVTDGIDVRRVVHLGRQPTKAMETALIVRDPTCVVPGCNVRTGLEIDHVDGWAATGVTRLDTLARLCHLHHAQKTYQGAHLHGPPGHWVWTPPADEPGPTAASPRGAAPAAPTGPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN3</accession>
    <name>A0A7K0JUN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF59 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000525">
        <property type="protein sequence ID" value="MST33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="27305" checksum="6DCCA25C59FDDCF4" modified="2021-04-07" version="1">MAFLPAADTEAAARRALDSVFDPELDEPITDLGFVRSVEAEGDGLVVHLRLPTSFCSPSFAYIMASDAKDALRGLAARVVVELDDHHDSERINAGLATDAGYRGTFRQEADRDLEELRATFRRKAHTAAMERALTRLLRTTPSLSEPDLPRVTIDDLPDDPQKAALLRCRAAVGLALDGSAVVLVDDDGHPVTAGTAAALLRRARTVRISVDGNAHFCRGLLATRYPGAEAEQSPRPGGDGTRLRGRTLGRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ7</accession>
    <name>A0A7K0JUQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8021" checksum="525C016B36411370" modified="2021-04-07" version="1">MSSSLVDLLDELLDAGAVVQGDVTISLAGVDLLSLDLRLLLCSVLTLSRPTADADEGDDDGGLPADLQPPTGAPCGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU8</accession>
    <name>A0A7K0JUU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">folE</name>
        <name evidence="8" type="ORF">GHK86_13550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000704">
        <property type="protein sequence ID" value="MST33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="7">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="22781" checksum="C4452EF5420A9F48" modified="2021-04-07" version="1">MTGVWTDEDDGGPRPLSAEGGQIDLGRIAAAVREILAAIGEDPGRDGLVETPARVARMYAEVFAGLQEDPARHLGVTFEAHHDEMVMVKGIAVYSMCEHHLLPWHGQAHVAYIPNSDGRITGLSKLARLVEGFARRPQVQERLTTQVADAIETTLAPAAVLVVVEAEHLCMSMRGVHKPGTRTVTSAVRGLFRRNAASRNEAMSFINQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV8</accession>
    <name>A0A7K0JUV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000547">
        <property type="protein sequence ID" value="MST33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15037" checksum="DD255A2ACC063F15" modified="2021-04-07" version="1">MSTTRSAASPAPPAARRATSPADGGTAIIGTVFGFLVFFVLLLFCVEALFHLYVASMVTAAATDAADTVAQSGGSPAAEPAAQATAVADLGGWGAQHAQFQWVEADGQLVRLRVVAETGALLPLPGLSRRIERTVTVRTEVFRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC0</accession>
    <name>A0A7K0JVC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">GHK86_12335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="WJHE01000617">
        <property type="protein sequence ID" value="MST33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="341"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="446" mass="48144" checksum="F966B5CA022C7F33" modified="2021-04-07" version="1">MRLYDTALRRIEPLELRRPGELALYVCGPTVYAEPHVGHGRFSLAWDVLRRYARWSGLAVRYVSNVTDIDDKIIARANEEGGDAAEVAARWEAVWWRTMDRLGVERPDETPHATAYVERMVDLIAGLIAGGHAYVGGDGVYFAATSVPDYGLLAPGPLDQLQVGARVEVGEEAGKRSPLDFALWKLAKPGEPTWESPWGPGRPGWHTECVVMSLDLLGEGFDLHGGGIDLAFPHHENERAQAEAAGRAFARRWVHSGHVVAEGGEKMSKSLGNTLSLPALLDAHDPRAYRLLALQSHYRRSMTVSPATLEAAGRAVDGLDGFGREFAAARDAEPDAGVRARFAERMDDDLDTPGAVAVLFEAMKQARAGGDGAVAAAVIDAWEKGLGLPLAREAQVPAAAAAKAAERDAARASKDWARADALRAELVADGYVVEDTPEGTRLRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD1</accession>
    <name>A0A7K0JVD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_14505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000774">
        <property type="protein sequence ID" value="MST33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="25226" checksum="320E3877CFDCE0E7" modified="2021-04-07" version="1" fragment="single">MEVSPKAFREVEFREKLRGYHPEDVDQFLEQMAAGVEVLQEKLRQALERAQRAEAQAAESGGSDETLRRTLVLAQRTADQAVQEAREQASHLLADAEQHANSMLAEAEERAQSTLAEAEERARRLHNEALADVRSELTKLEATRAHSQQEVELLDRWADEQRSHHHPRGAEGRGQQVLVPDVAGGGDGQGVGWGRPEPGDVEGEGAPSQRGRQPAEVVAGDAFGGERRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE5</accession>
    <name>A0A7K0JVE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000771">
        <property type="protein sequence ID" value="MST33918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="25224" checksum="8F93A9B6A6487267" modified="2021-04-07" version="1" fragment="single">MPGPSWTGSSARWTTSASATGWATSPNRNRPSCATRSTPTPSRRPRPRDAPAATSDPSARPAGRRLPQGHRQVGTMGPGAAPSGVGRMLGGRAARRRGMRTAARRTAEGLVVAGGVVLLRPGTRANKVVCRSVDEAGRRLRYAGGRLQGLSYRLGGRHPDPHVGDNVLADRIRSSVGGLEKRLDLPHVHVTVERGVAVLHGEVGSAEDARQLERAVEAVSGVAGVESYLHVGLGAGDTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI2</accession>
    <name>A0A7K0JVI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IstB_IS21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000789">
        <property type="protein sequence ID" value="MST33958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17654" checksum="D8653DA4A2D79A13" modified="2021-04-07" version="1">RGHPHLTGQQPPKLLQSVAVPSGTGKSHLTEALGHAAVNAGLRVVWFSVEDLGALVRRHRVDDTIAKAFTPILRSELVIVDDIGLLPLSADAAEGLYRLVDAAYERRSLAISTNLHPSGFDQLMDRTIATALVDRLLHHAHVIVTDGDSVRLADALTGKGVTPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL3</accession>
    <name>A0A7K0JVL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000793">
        <property type="protein sequence ID" value="MST33971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="23319" checksum="1A4D4B2D92E1E41A" modified="2021-04-07" version="1">MTTNVYIDGFNLYYGCVKGTPCKWLDLEAFCRTLMPQEQIRTIHYFTARVSGRLDPSAPTRQNTYLRALATLPSVEVHFGSFLTNNVWMLLANPPLRGPRKAQVVKTEEKGSDVNLAATLLMDGFRRAADTVVIVSNDSDLTEPVRLARYELGLRVGVINPHPANKRSLTLSREAHFFKQIRPAAVRSSQFPPTLVDATGTFHKPTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN6</accession>
    <name>A0A7K0JVN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000790">
        <property type="protein sequence ID" value="MST33962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="43208" checksum="4A49BEBD99E3DA3A" modified="2021-04-07" version="1" fragment="single">MDGPPPFGADRLVTLADWQDPPGNRWAFQHVRELIPTARIRRGPGPVWELPRAERDLTGVRFGALGREWTVGEMLAGTQTDGFLVLHGGRVVTEVYDNGMEPDTPHLLMSVSKSVTAALAGVLVGDGALDPDAAVTTVVPELAGTSFDGATVQHLLDMRAGTRFDEDYDNLDADVRTYEQVYLWRPRTDPAAPPDALAYFPTLGNDGDHGGPFRYRSVLTDVLAWVLERASGRRFHEAVTRLLWEPMGAEFDADVTVDGHGNPMADGGVSMTLRDLARFGLLYLRGGERDGVPVVPRAWVEDTVRGAPDGAAAFVAHEPQEGFPAGAHYRNCWWVVDPAAGFLHGSGIYGQNVYVHRPTDTVVAKLSTWPTPLSAEEVDHGRRAGGVGGVPRLHVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP0</accession>
    <name>A0A7K0JVP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000811">
        <property type="protein sequence ID" value="MST34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="35529" checksum="F557E10C66BEDB24" modified="2021-04-07" version="1" fragment="single">MPGPLVGVRIVELAGIGPAPFAGMVLSDLGAEVVRVDRPQQVRPGAPPPVGDVLGRGRRSIAVDLKQDAGRDVVLQLVDSADALIEGFRPGVTERLGLDPTTCLARNPRLVYGRMTGWGQEGPLAGAAGHDINYIALSGTLSLLGRREGPPVPPVNLVGDFGGGGMLLALGVVCGLWEATRSGRGQVVDAAMVDGAALLAAMLWGFHGAGGWGARGTNLLDTGAWYYEVYETADGRYVSLGSLEPQFYAEMLERTGLGADGRGPLPDPGDRSSWPSMKERMAALVRTRTRDEWCALLEGSDACFAPVLDLDEAPGHPHLRARRTFVEVAGVTQPAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ0</accession>
    <name>A0A7K0JVQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000817">
        <property type="protein sequence ID" value="MST34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="15139" checksum="6D281AADB701350C" modified="2021-04-07" version="1" fragment="single">MVEHAGEVGYRGPQVCSIVGITYRQLDYWARTDLLRPSISDARGSGSQRRYSYGDLVQLKVIKRLLDAGISLAQARRAIECLRATGEDLATSNLVIEEGRSVLAHSGEEIVDLLRGGQGVLNIVPMAGVVSEIESAITTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ1</accession>
    <name>A0A7K0JVQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000817">
        <property type="protein sequence ID" value="MST34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="18120" checksum="7520B9E91E2E82DC" modified="2021-04-07" version="1">MVEMRLASVRVEMSTRTPILLLQEAGGGNRTLPIYIGPAEAQAIAQALQGVVAPRPMTHDLMRDLLNELGAVIDSVVITELRDKTFYAEIRLNAGGRTHHVSARPSDAIALAVRTSATIYADDALVDAEGVVLEADEDEEDDRDTDELVSEFKAFIEGIRPEDFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR4</accession>
    <name>A0A7K0JVR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000671">
        <property type="protein sequence ID" value="MST33644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26292" checksum="31E2D5AD1D58FE8A" modified="2021-04-07" version="1">MSQTMDTAFRRIGSEARQGTFGAPDTWGPSRTYKASRAYDKLIGLTILALVAGIAGWAVVPSGIAFLALIVAFVTVLVSWFRMRWAKVLAPIYAVCEGVGLGAISGLYASQYSGIIPLAIIFTAGVFLATLGLYRTGLVRVTPRFASMAMIGAGGLIAVGILSLFIALPIFNAASPLWAIFGVLCLFIAVTNLFVDFDYVQRAEAMRMPAEAEWASAFAMMTALVLVYLSILRILAMFAGGGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW0</accession>
    <name>A0A7K0JVW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PqqD family peptide modification chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000839">
        <property type="protein sequence ID" value="MST34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="7609" checksum="326CFEDE8F04ECEC" modified="2021-04-07" version="1">GLVVLPPDRAACLAVSGATGLLWELLAEPVDADELVERMAAETGADRAAIRAQVEVGLQVLAEAGVLCRAARAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW46</accession>
    <name>A0A7K0JW46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flippase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_15785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000884">
        <property type="protein sequence ID" value="MST34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="354" mass="36991" checksum="E46D4CB9932B5665" modified="2021-04-07" version="1" fragment="single">MSAAPLPPDAPPEPDPSPEDGSDAAPRKRWRRFLPAPVVQIGRLLIVALIVEYLVVPQIAGTRKALHTLADVNPLLLLLGVALEVGAIASYTLSTRAILPSGTYPGFFRLLRIQLTTLSVSHCVPAGSAAGTSLGYRLLAAAGVERTDAAFALATQALGSAIVLNAIFWLALVVSIPVWGVSPLYLTAAAVGALLVGLFVTLVLAFTRGARRAGDVIYRVAARIPLVDPDVVRGLFIALGVRMTELGRDRRTLGRAIGWAALNWLLDAASLEVFVGAFGHWVNPDGLVVAFGLANVLAALPITPGGLGVVEATLTSALVGFDTPRAAALLGVVAYRLVNFWLPIPLGGAAYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW49</accession>
    <name>A0A7K0JW49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coenzyme F420-0:L-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cofE</name>
        <name evidence="9" type="ORF">GHK86_13715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000718">
        <property type="protein sequence ID" value="MST33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="F420_ligase" evidence="8">
        <location>
            <begin position="72"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="231" mass="24355" checksum="61F97145A5C65948" modified="2021-04-07" version="1">MSLTLLPVEGIPEVRPGDDLVEHITAHAELVDGDVVVVTQKIVSKAEGRLVPVDPDDRAARAAIVGGESARILRRRGDLIMTETHHGFVCANAGVDLSNVEAGWAALLPVDPDRSARRIRDGLRARAGVRVGVIVSDTFGRAWRRGVTDVAIGVAGVAGVVDLRGTADALGRELAVTEVCVADEIAGAAELVMGKAGAVPVAVVRGVDPAWLRDGSVAEEIVRPYREDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI4</accession>
    <name>A0A7K0JWI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_16475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000939">
        <property type="protein sequence ID" value="MST34310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="25992" checksum="FDC3FAC821346DEA" modified="2021-04-07" version="1">GPAVVRLEVRRLLRNRRTLIFTVIAPTLFFLIFGLNGAYADLRAGRGNVSASVLISMALYGAVLATTSGGATVSLERAAGWTRTLRVTPLSSAAYIAVKMVASLVLGSASVAVVYVVGAASGKPAMPLWVWIVSAVATWIGSLVFTAFGLFVGYLLPSENVMQIIGFTLMLFSFGGGLFIPLSQYSPALRTLAEFTPLWGLNGLVHFPLMGGAFDVGWVANLLAWLVLFSLGAVWRFSRATSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK7</accession>
    <name>A0A7K0JWK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GDE_N_bis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000950">
        <property type="protein sequence ID" value="MST34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="1">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="28452" checksum="412444D45307375E" modified="2021-04-07" version="1" fragment="single">MPGSWTVAGSGDRLVMVEGAAFLVAGPTGAVAPRRAEGFFFRETRFLSRWELTVNGRTPEALAVSAPDPYRATLVSQAVPSDGRGDATLLVLRHRFVGRGLREDLVVRNLADEAAYCAIELAYDADFAELYAVRSGQGLPEGSPEAVERAGALVFTHRHGAHRRELRVALSAPVTFDGNLARAEIVIPARGEWSCCEEFVCAFDDVAVEPRWPCGQPVSRAKPAERMAAWRRSVPVVETDHAGLRDVVAGSAEDLGALRIFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR0</accession>
    <name>A0A7K0JWR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AfsA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000975">
        <property type="protein sequence ID" value="MST34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="10689" checksum="93ED8F0511D0E4FC" modified="2021-04-07" version="1">MSWSQTVPRELVHRAALSEVLLTDSDRVDDDEFVVGAQWPRAHSFYGPDIDGRHDPMLAAETLRRAGLLLGHRYYNVPSGHQFIMRHLGFMVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU6</accession>
    <name>A0A7K0JWU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="8" type="ORF">GHK86_17045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="WJHE01000997">
        <property type="protein sequence ID" value="MST34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="13"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="26883" checksum="D0340775193AFC8A" modified="2021-04-07" version="1">MGPTAADGDPLVIAGRRLSSRLILGTGGAPSMASLEASIRASGAELVTVALRRVAPGVAGSVLEVCDRTGVAVVPNTAGCRTAREAVLTAEAARDAFETDWVKLEVVSDDRMLLPDPVELLDAAGRLVDDGFRVLAYTNDDPVCAIRLADLGCAAVMPLGAPIGSGMGIRNPYNLAIIREQVGVPLVLDAGIGTASDATLAMELGCDAVLVASAVTRARHPELMAAAMADAVRAGRLAHRAGRIPRRLYAQASTSPAGLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW3</accession>
    <name>A0A7K0JWW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001008">
        <property type="protein sequence ID" value="MST34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="9776" checksum="8FEDA797BC760357" modified="2021-04-07" version="1" fragment="single">MSPPDDEALGMAASMHPDTADALLGGAAPPGFEELAAWLSAIRPGPGRADEPLERLAVDALTGARGPARAGAPDGRRGVAVRLLTVKAVAIAGTVALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY4</accession>
    <name>A0A7K0JWY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">araA</name>
        <name evidence="8" type="ORF">GHK86_15260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000838">
        <property type="protein sequence ID" value="MST34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="363"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="504" mass="54581" checksum="6B2CD4AB6AE1105E" modified="2021-04-07" version="1">MTVTDERPTCWFLTGSQALYGEETLRQVEEQSRRIVAMLNDAGELPVDVQWRPVLTDADAIRRACLDATGSDGCVGVLAWMHTFSPAKSWIAGLDALRKPLLHLHTQVNRSLPWDSIDMDFMNLNQAAHGDREFGYLETRMGVRRKTVVGHAGDPAVRSRIGEWMRAALGAAAARSLRMARFGDNMRDVAVTDGDKVEAQIRLGVAVKAYGVNDLVAAVDAAGPDEVDALIGEYAERYDVAPELASGGDRHRSLRDAARIEAGLRAFLGAGGFEAFTTNFEDLGGLRQLPGISVQRLMHDGYGFGAEGDWKTSLLLRILKVMGEGLPGGTSFMEDYTYHLGPGQPKILGAHMLEVCPSIAAGRPSCEIHPLSIGGRDDPVRLVFDAAPGPAIVVGLLDLGDRLRLVCNDIEVVPPDEPLPRLPVARAVWEPAPSLAASAECWLTAGGPHHTVLSSAVSPEALADLAEIIGVELVRIDASTEPGRFRQELRWNDAYYRLFPAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ2</accession>
    <name>A0A7K0JWZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001023">
        <property type="protein sequence ID" value="MST34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="261" mass="26889" checksum="7F9F8E275B80BE13" modified="2021-04-07" version="1">MPDGPLAGARILVTGASSGIGEATARVLATRGARLAAAGRNRSALAELGEATGAQALPGDLLDPAEARATVRRALDALGGLDVVVSNAGIGWAGPFDEMTPADIDRLLDLNLRATAHLVHAALPALRHSGGRLVLVGSIAGMLGVPGEAWYSATKAGLAGFADALRAEVTPAGVGVTLVTPGVVATRFFDRRNRGYDRQRPRPVAAERLAEALVAAVEGGRDELVYPGWLRLPARLHGGLPGLYRALARRFASPPTALRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX29</accession>
    <name>A0A7K0JX29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001045">
        <property type="protein sequence ID" value="MST34507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="16504" checksum="0FC3E77940444034" modified="2021-04-07" version="1" fragment="single">METAVSSGAGGPGSTPVTAAAGRIVVVGSLNLDHTVVVERLPARGETVSGSAYRTAAGGKGLNQAVAAARQGATVAMVGVVGEDPAGSLLTGVLAEERIDVTHVRRAAAPSGTALVTVDRHGGNTIVVAAGANAELRPEDVSGEVLAGAAVVVCQMEVPVEVVHAALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA2</accession>
    <name>A0A7K0JXA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsO</name>
        <name evidence="7" type="ORF">GHK86_17890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001083">
        <property type="protein sequence ID" value="MST34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9993" checksum="4BAC5CDEB2885475" modified="2021-04-07" version="1">MPDKAATIATYRLHETDTGSPEVQVAILSERIAHLTEHLKVHKGDHHTRRGLMKLIGRRRRLLDYVRDNDVERYRELIARLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG6</accession>
    <name>A0A7K0JXG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000906">
        <property type="protein sequence ID" value="MST34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="29685" checksum="E0B5F1A5D6FBCC70" modified="2021-04-07" version="1" fragment="single">MRDMALAVAPSPEERLTDLLSVRALSVRYGSRAALDGVDLQVRPGEFVALAGENGAGKSTLVRCIAGEIAPDAGRVLIGARPAHAASSDVAVVWQDLALCDNLDVAGNLLLGRESRRIMLSASRQHAVARRMLADLGIPLTDTTQDVRTLSGGQRQLLAVARAMRDRPRLVVLDEPTAALGVAEGRQVEELLTSLHAAGITVILVSHDVEQMFRLADRIVVLRKGRVVDDVRPEASHPDDVTALITGQEVDTSARRQLDRLHGLVDQLTSADPGSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG8</accession>
    <name>A0A7K0JXG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmH family RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001128">
        <property type="protein sequence ID" value="MST34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="18929" checksum="E5FAC87C984BE40D" modified="2021-04-07" version="1">MKQLGPTDLKRLHREWNRRSRARVALLLDGVSSPFNVGAIVRTAAALRVSHLYLAGGALSPAHHRVGRTAMGTERYLTWSSHERGTDAVEAARADGYRVVGLELADAAVPLHRLEVPGDACLVVGHEDHGIPPATLAACDAVAFVPQLGRVGSLNVATAAAMALYELRRREWAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK9</accession>
    <name>A0A7K0JXK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoacid:acceptor oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001149">
        <property type="protein sequence ID" value="MST34686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="269"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="647" mass="68983" checksum="49EB116421C47DFC" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM1</accession>
    <name>A0A7K0JXM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GHK86_18450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01001157">
        <property type="protein sequence ID" value="MST34697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MST34697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="17873" checksum="24548365F4EFF558" modified="2021-04-07" version="1" fragment="single">MLAALGFLTPFGPARAPSPTTLRWFPLVGAVAGAVVGLVWWAASKAWHGPLVPAALAVATDLILTGMLHVDGLADSADGLLPHLSRERRLQVMSEPDVGAFGLAATAAVLLLRFAALSALRPDIALVIGVWGVSRSLMVAAMLVFPYARTTGGLATAFLGGGVAGSALAAAVGAVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM6</accession>
    <name>A0A7K0JXM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000928">
        <property type="protein sequence ID" value="MST34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="33718" checksum="6817315EBBADA704" modified="2021-04-07" version="1">MDRDAIGWVGAVVGDLLFRSPPPGIVWRADRRTPPLSVRFRSAEEDFATLVYPDDEQALATVQFAAEAQQAVVARQHTPLPACREHRVSLDPYVNEEGQAGWRCSHGDVHCAVGDFPETLWPPRWWERLDPPLVSDRLVRRGLRYVTLGVDDSFDGQVVSAQLPEGADLAAYEAAVAPYPFRVTRWLPPDRTTRRDGETGRDGVRYRSLSRSGVRHLAGLGGQLDRAGPNEAGDFVIINGPDDRTPVRLLAAHLLSDTEPFLLDQHGNPFAAIGDDARCTGGYEPSPVDGEPLVFVASELRVRESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP5</accession>
    <name>A0A7K0JXP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001173">
        <property type="protein sequence ID" value="MST34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="263"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="408" mass="42917" checksum="39D54E113E1F6E29" modified="2021-04-07" version="1">VSMVRQAATRRKPLVYLGAGVALAALLAVVLFAGVGSRGGPQGLASTRQEVLSPDTAPGINASTGLLLSLTVLHQQQPAAPPFRLTDQYGHVVSPASFRGKVVVVSINDDRCQDLCTFYAADVVRANQDLGAAAKHVVWLSVNANPFYPAVSAVRTWTDEHGLAGQHNWYFTTGSPAALAKVWHAYGFYVQLDHKTRTVSHSTEQFFVDPAGHERAVGEFGAASASTALFAHGMAQMANDLLPASEQVHVAGPETPAPSGSNATVGAPAPPLALHYLQGGRGTFDLAGDRGHYTVVNFFASTCTVCRTELPALERVYHFARSKVDFVGVDVSDRASAARALLARTGVTYPVVSDPNGTASGAEQVTGLPYTVIVGPAGKIVIRHPGGFTTEQLEYLLEGDVPSLAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ5</accession>
    <name>A0A7K0JXZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001244">
        <property type="protein sequence ID" value="MST34833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="26001" checksum="8D4273A9807B8971" modified="2021-04-07" version="1" fragment="single">MAADLLRVALLVYRGNPHSGGQGVYTRYLARELVGLGHEVTVLAGQPWPVLDDGTGFVGVPSLDLYRQPDPFRLPRLWELRSAADVAEFAIMCTGGFPEPRTFSWRVRRVLAAQRGRYDVIHDNQTFGSGMLDLMADGWPLLGTCHHPITVDRTLDLRHAATWRRKLSLRRWYGFLAMQKRVARQVPRIVTVSESSKRDIVEQMGIRPERLAVVPIGVDHERFRPRPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY53</accession>
    <name>A0A7K0JY53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001279">
        <property type="protein sequence ID" value="MST34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="12729" checksum="E78F103C38302BC1" modified="2021-04-07" version="1" fragment="single">MGREDGVVAGTNGSGAAGVDATQTRSHVAFAVRGLDLSFGRQAVMRGIDVEIPRGRITALIGPSGSGKSTFLRAVNRMNDHVPGFRASGEVRYGGVDLLGPGIDLIALRRRVGMLFQRPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY80</accession>
    <name>A0A7K0JY80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001292">
        <property type="protein sequence ID" value="MST34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="14560" checksum="2E07E1056DE36B13" modified="2021-04-07" version="1" fragment="single">MSLTLAPTPRDAHAHPTPGPPPGWRARWLGARARWLHLALLIAFPGCLYAGWWQLHRALSGNTLSYLYTFEWPLFAVLSVWGWWQLLHAPVGSELDVVGRAADLPRWSPEEESPELRRYNELLDQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC7</accession>
    <name>A0A7K0JYC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001329">
        <property type="protein sequence ID" value="MST34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="7718" checksum="ACFFA7649B6AB89D" modified="2021-04-07" version="1" fragment="single">MSGAEREATGRDAGAGRRALRPLWMQVYLPNLLLATGQGAMLPVLVYAARDVHASSAVATALVAVNAFGTMAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH7</accession>
    <name>A0A7K0JYH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001083">
        <property type="protein sequence ID" value="MST34584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="1">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9241" checksum="AE5F893F7B47DCEB" modified="2021-04-07" version="1" fragment="single">MADPDELRVAPGVVVPGTELAWRFSASGGAGGQHVNTANTRAEVVWDIAGSPSLPEPLRERLTARLGPVVAVAASDRRSQRRNRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU6</accession>
    <name>A0A7K0JYU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_20590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001445">
        <property type="protein sequence ID" value="MST35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="16201" checksum="508503C44CA21488" modified="2021-04-07" version="1">MDDVDRELVRLLVADARLTYQQLAQAVHLSANSTADRVRRLRSGGVIAGYRAELDLARLGRTLVAVTDVKLKEAEGRLRFESDLEEVPAVLGAVHTTGEYDYQLRIASTGTADLESVLDALRRLGASEGRSAPPGCRRWAGGSPWRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY8</accession>
    <name>A0A7K0JYY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001198">
        <property type="protein sequence ID" value="MST34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="28527" checksum="C16F52BF6B0A4342" modified="2021-04-07" version="1" fragment="single">GTGGSGKSSLTDELIRRLRLDQEDKLAVAVVAVDPTRRKGGGALLGDRIRMNAIDGDRVFFRSLATRGAQAEVPDALADVVAAARAGGADLVVVETPGIGQGDAAVVPLVDVSLYVMTPEFGAATQLEKIDMLDYADAVAINKFERRGGADALRDVRRQLARDPERHGTPHDQLPVFGTVAARFNDDGVTALYQHLRERLSACGLAVADGTLAPVATRVSSLQDAVVPPARSRYLAEIADTVRRYHARTDELAAAARRRQQARAVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ16</accession>
    <name>A0A7K0JZ16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6458 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001516">
        <property type="protein sequence ID" value="MST35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045597">
        <property type="entry name" value="DUF6458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20059">
        <property type="entry name" value="DUF6458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6458" evidence="2">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9147" checksum="D0D553645DDBFEDB" modified="2021-04-07" version="1">MPYAGGMGTSVVVFAIGAILDFAVNVQSNAVNWHTVGVILMIVGAVGFVVTLVLTMMFNSGGTYRRSRRVTQEPNGTYVEERGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ17</accession>
    <name>A0A7K0JZ17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CcmF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001492">
        <property type="protein sequence ID" value="MST35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CcmF_C" evidence="2">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="15857" checksum="B7FF82ABEEB6B6E3" modified="2021-04-07" version="1" fragment="single">MVLIAVAFAASHSFEHQTQVTLKPGQTATYQGQHVTYLRMQAVQGPNRHGVAADVLLNGQLLMRPAVNDYPASGESVPTPAIHSTPAHDVYLTLATTPAGNKAVTLGIIVEPLVSWVWIGGLVVVLGSVLAAVPGRRRRLPTRPLTVGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ19</accession>
    <name>A0A7K0JZ19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001218">
        <property type="protein sequence ID" value="MST34794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="14326" checksum="2584F609DD41E8A5" modified="2021-04-07" version="1">MPLSEDENRILNQIEQRLYAEDPASAERISSTTLPRYLARNCGWAALGFVAGLVVLLVGFTTSWVLGLLGFVIMVGSAVVFVQNLRMMGRHGLRQLSTSLQERSWSTLAGDTGRRLRRRFGDGRDERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC1</accession>
    <name>A0A7K0JZC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001607">
        <property type="protein sequence ID" value="MST35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8903" checksum="CD87F709190DFB46" modified="2021-04-07" version="1" fragment="single">DGEWVVDLRHRKAFCEGHVAGTLNFGLDGSLATYLAWLIPWGTPVTLLGETAADVAAAQRELVRVGIDRPAAAATGGRSMPTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE4</accession>
    <name>A0A7K0JZE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001645">
        <property type="protein sequence ID" value="MST35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9002" checksum="0BE39CDD9E2E87ED" modified="2021-04-07" version="1" fragment="single">MTAGVHVVLVHHDQPDLCARSVDAFRAQAGVREVTVVDSGSTPTARGRLRELRPGLVVVDAGANVADPRKGDGLGCVGSEVDEQGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JME6</accession>
    <name>A0A7K0JME6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="357" mass="37794" checksum="2CEE2DCA9D9F6836" modified="2021-04-07" version="1">MTQETVAVIGGGPAGLAAAQAAVDLGSPVVLIEQRQFLGGTPIAEDYASLTPYLRPAEEVLGGLIDRLRGGPGIEILLGAEVVACTGEAGAFELSVEVGGSVRSVACGAVVVATGFQHFDPGRETQMYGYYEFPDVIALQDLEAMIKSGAVTKPSTGEPPRRVCFVQCVGSRDRQIGNEYCSKVCCGVASKEAIEVREMLPDSEVFIFYIDMRMYGYWESQLYWPAQERHHVQYVKGVISEVLPKGDQLLVRGEDTTMGRPMEVLMDLVVLSVGMEPSPGTRAMAGVLGVRQNRYGFIESVNPPLDTVSTSRPGILAAGAALGPSDLEDCASSGAAAAARAVAMLRSLGRTGRVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMI9</accession>
    <name>A0A7K0JMI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_00260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046278">
        <property type="term" value="P:3,4-dihydroxybenzoate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012794">
        <property type="entry name" value="PcaR_PcaU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02431">
        <property type="entry name" value="pcaR_pcaU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="71"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="28507" checksum="74A3AF49BFDC769E" modified="2021-04-07" version="1">MAEEPRRPEHVQSFARGLAVIRAFGERPELTLSDVARATGLTRAAARRFLLTLVDLGYVRSDGRTFALRPRVLELGYAYLSTLGLDDVAAPHMEQLVASIRESSSISVLDGDDIVYVVRVPTSRIMTVTIAVGTRFPAYPTSMGRVLLAALPPAALDAYLERVEPVALTRRTVTDRAALRAVLGEVAAKGYALVDQELEDGLRSVAVPIVDRSGAVVAALNASAHASRATLEDLRRRMLPQLQATAARINDDLRAVGRTAARAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMN2</accession>
    <name>A0A7K0JMN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsQ</name>
        <name evidence="7" type="ORF">GHK86_00545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="13420" checksum="11B73DB8884CCB3B" modified="2021-04-07" version="1">MSSSESNETVAPDEAAAVTSAEPLVPEELREGADEDRPNRRKVREGLVASTAMDKTVVVAVVERVRHPRYAKTVQRTKRLLAHNEDPALKVGDRVRLAETRPLSKRKRWRVVEVLERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMP2</accession>
    <name>A0A7K0JMP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9033" checksum="21AC9C11DC627149" modified="2021-04-07" version="1">MLVDILSTIPEYAYATRDAGGHQGRQIAELARSGLSNPEIATRLFVSPRTVEHHLGKVFAKLGIRTRGELQAVLGTGPGRGPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMP5</accession>
    <name>A0A7K0JMP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="24840" checksum="7730D083816B7EE0" modified="2021-04-07" version="1">MTPPSKQAPVALVTGANQGIGLETARRLATAGCTVYVAARNRERGTVAAAEIGARFVALEVTSDVSVAAAAAQVEADVGHLDILVNNAGITGPQDNVHDLTGAGIEQVLATNVVGYVRVIHAFLPLLERAERPRIVNVTSGLGSLARFHDRSRIESRAGSPFYAASKAAINMLTVRYARALPDLRINAADPGLTATAFSGGMGHSVGDGTDAIIRFAIGEDQDLTGRYRDRDGDVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMT6</accession>
    <name>A0A7K0JMT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000025">
        <property type="protein sequence ID" value="MST31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="12717" checksum="DE61107CF0119DF8" modified="2021-04-07" version="1">MRPVGLHHVSINVDDVDAALAFYVDALGLTVRQDRPAFAFGGAWLDAGGQQVHLIEAAPPPNQGQHFALAVEDLAAVVAELRRRGLQVTDPKPVGGSLQSFLADPAGNRVELHQPQVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN75</accession>
    <name>A0A7K0JN75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000061">
        <property type="protein sequence ID" value="MST31405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="348" mass="37220" checksum="51F0D3E6C17B66D4" modified="2021-04-07" version="1">MEQQSPDLDGVGVRHRATIAEIARAADVSRQTVSNVLNAPHRVREETRRRVEQVIADTGYRPLKSAQSLRTRRSNLLAVGFQSPGAEPSPVLDVFLHALSTSAQTLGYQILLLTAGSDGAEIQAYTEAVVDYAVDGIVLTGTHTHDERIDWLRRQRLPFVTFGRPWGALGGHSWVDVDGAAGTRAATEHLARAGHTRIAFLGWPAGSGSGDDRLQGWKQACGRAGLPTRGLLRRSANTIEDGRKTCAAVLDQPRPPTAIVCVSDALAVGAWLEMRDRGLVPGRDVALIGFDDSTTASVIGLSSVAQPLPAVADACLDALRGQLGSEGPSSGRWRQVLLQPELVLRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI9</accession>
    <name>A0A7K0JNI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000088">
        <property type="protein sequence ID" value="MST31515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="210"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="395" mass="42260" checksum="4A3EF5D3AEB48FF6" modified="2021-04-07" version="1">MRVLVLHNRRRATTTPSGEDRVVDVEVAALRAAGHDVDTCGPHSGDLRPVSLRAATLPATVVWNPESYLTVRRVLRRLGPDVVHVHNTFPLLTPSVLAAAGAEGVPVVVTLHNYGLGCPGGELLRDGRYCNACVGRSGLRALRHACFQHSRPKTVPVVATQVVNRRAWSGRPSAYIFLSRAQRRELAAAGFPRERCFVKWNLVPDVPVPPAPDGPPYVAYLGRWVEAKGVDVLMRAWEQVPCLPGGLRLVIAGGGPLEPTLRAWAATQRAVDVVGGLPPDQARALAAGARAVVVPSTWREPFGLVAVEAMAAGVPVIASRHGALPELVNDGVDGVLCTPGRPGELAAHLRSVALDPDRWAAMGRAARGTYLRAHDPAANVEQLVGIYRYAVRHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL1</accession>
    <name>A0A7K0JNL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="4" type="ORF">GHK86_02270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="16938" checksum="72A1ECF2464ED63A" modified="2021-04-07" version="1">MPPDRLEVGRIVRAHGLRGQVVVELVSNRPERVAPGAELTTPDGRRLVVLRAGPASPSGGRQRYLVAFDGLTDRESAESLRGVVLSGEPIADPEALWVHELIGSAVRDVAGAPLGTVVAIEANPASDLLVLDGGALVPLRFVVEQRPGEVVVDPPEGLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ0</accession>
    <name>A0A7K0JNQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">rplA</name>
        <name evidence="11" type="ORF">GHK86_02025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000086">
        <property type="protein sequence ID" value="MST31507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="243" mass="25375" checksum="248274A75C8FE7C0" modified="2021-04-07" version="1">MPSRGKKYVDAAKRFDRQRSYGPGEALDLVKSLAHAGFDETVELAVRLGVDPRKADQVIRGTVSLPAGTGKEVRVAVFAAGPAAEAARAAGADIVGADDLVAAVDGGMMDFDIAIATPDLMGQVGRLGRKLGPRGLMPNPKTGTVTTDVGKAVTDFKGGRVEYRADTRSRGVVQVPIGKVSFSRQALLQNFRAVVDEVNRAKPAAAKGRYIKSVAVSSTMGPGVDVDVNALRVTDEELDGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ4</accession>
    <name>A0A7K0JNQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000101">
        <property type="protein sequence ID" value="MST31585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="19170" checksum="CEA74F68C404E1CF" modified="2021-04-07" version="1" fragment="single">MMVHECDGSDHRLETYAVRDRRLLEQVEAFNRRLVAGFAGGRDLTATLAALDPDPARYTWVDEGGGLVGAVLADAEAVLAAAPALPGFRCLPSAMMPVAAPSARPAVATGPDGSLLVAWVEWFPDQGERVVAVRADASGSPMTEPQVLSGPLGDCLRPSVAFDGDGAAWVLFGLRRGGEAGTGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX7</accession>
    <name>A0A7K0JNX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4032 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000099">
        <property type="protein sequence ID" value="MST31571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025111">
        <property type="entry name" value="DUF4032"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13224">
        <property type="entry name" value="DUF4032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4032" evidence="1">
        <location>
            <begin position="229"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="424" mass="48269" checksum="9ACECD3423332EB8" modified="2021-04-07" version="1">MEVQIARGGPYVHVMDFEWDHPLESWNDPRLVRMARGPSRHVVRFVELEGRVLAIKEIGDRLAKREYTVLREMLDADIPAVEPICTVTERRDPRGEALPGAVVTRYLDFALPYTYLLARENGVEHQRRLTDAAAVLLVHLHLEGFWWGDCSLANILFRRDAGGLAAYLVDSETAEHHARLSDRQRETDLDIAVDNIAGGVADLLAAGRLEAHTDPLDFAQRLETRYRALWGELTVEEEFGADQLWRLDERIARLNRLGFDATELSVRAGEDRIRIRPSIVEEGHHSRRLRRLTGIEVQENQARRLLNDLGSHRAAFERREGRPLSEAIAAHRWLTESFEPFVSAIPGPLAARLEPAEAYHQYLEHRWFLSEAAGRDVPDDVARRSFFDKVLSQRPEERVVLPDPTGELDLLALEEAEDPGDPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP01</accession>
    <name>A0A7K0JP01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000119">
        <property type="protein sequence ID" value="MST31700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16599" checksum="44C961D9DC2ED2AC" modified="2021-04-07" version="1">MNGVAAEAFRRVTVPLGPDGLHPLTMAAAVAATDPRRGSVRVLHVRSGEPLPLPLGQDGGLLADAPDLYRETSEEASGILLSALRGLCACGVEAEGMVAEAPRPLVGAVLADAAEAWDADLIVLDRRPRGLLDGVLRRGVVEDVVRRASCPVLVVSRGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP13</accession>
    <name>A0A7K0JP13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000035">
        <property type="protein sequence ID" value="MST31309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="411" mass="43494" checksum="03E7782D5F9017C4" modified="2021-04-07" version="1">MPAGGRLSAEAAVAICELLEASRGVHAGQLGEMICRTAERLGLADARLWLADLQQHCLVPYGGLAGDGEDGCLSIDGTLAGWAYRSGELQCADADSGTAAAWVPLVDGGERLGVLGGEMTDREEATVAGLRLLAGLAARFVASDQRYGDLAARTRRLRPVSVPAEVQRSLLPPLSCATTTTAIGGVLEPAYDIGGDSFDYAVSDDRAWLAVFDAMGHGLNAALMVSLAVSAYRHARRTGADVAGCYERVDETIASQFGPDRFVTGVLAELDTTTGELVYLVAGHHPGVVLRAGRVVRHLGDAVRLPFGLGNGLGPIPSQPTNTRIGAERLEPGDRVLLYTDGVVEARDRAGDFFGLDRLEELLVREDASGSDVPETLRRLVHAVLEHQDQDLQDDATLVLLQWRAIVAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP80</accession>
    <name>A0A7K0JP80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000044">
        <property type="protein sequence ID" value="MST31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="531" mass="52021" checksum="33EE39D2D93CD1E5" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB9</accession>
    <name>A0A7K0JPB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029475277" evidence="1">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="25820" checksum="D0CEBA301A832AC0" modified="2021-04-07" version="1">MRLSGRVALVTGAASGLGAGIAEAFAAEGAVVCMVDVAEEAKAAAAVAAADRYGHGTLYHRADVAVAPQVADMAAVALGHFGRVDILVNNAGIFTESRLEDMPLEDWDRVIAVNLRGTFLCTRALIGQMLERGWGRIINMASQLGQIGGADVAHYSASKAGVIGFTKALAREVSTRGVLVNAIAPGPIRTPMLDGETEEWRSRKLSELPIGRFGEVDEVTPTAVLLASDGGSYYVGQTLGPNGGDVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC4</accession>
    <name>A0A7K0JPC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TusE/DsrC/DsvC family sulfur relay protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tusE</name>
        <name evidence="5" type="ORF">GHK86_03505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DsrC/TusE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000138">
        <property type="protein sequence ID" value="MST31795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042072">
        <property type="entry name" value="DsrC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025526">
        <property type="entry name" value="DsrC-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043163">
        <property type="entry name" value="DsrC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007453">
        <property type="entry name" value="DsrC/TusE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37010">
        <property type="entry name" value="PTHR37010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04358">
        <property type="entry name" value="DsrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006223">
        <property type="entry name" value="DsrC_TusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69721">
        <property type="entry name" value="SSF69721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03342">
        <property type="entry name" value="dsrC_tusE_dsvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006223-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="11383" checksum="958F4C8CCBE27B20" modified="2021-04-07" version="1">MPTRTYAGVEVAVDEQGFFLDPSRWDEAMAPEIAAAEGVAELTDRHWQVVKFMRHEYEEKGTGPSVRALGKTSGVPIKELYALFPGGPAKLAAKIAGIPKPRGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI0</accession>
    <name>A0A7K0JPI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein ZapE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zapE</name>
        <name evidence="3" type="ORF">GHK86_03905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000159">
        <property type="protein sequence ID" value="MST31870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="2">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="29946" checksum="A883F896CD14D344" modified="2021-04-07" version="1">MTAPAPTVSPELRSLLRRVKLGKALDTLPERLALARSRDLGHAEFLELVLSDEVTRRDTHSADLRARTAGLDPAMRLEHWDDTAKLTYDRTILDELVSLRFVEAAHNALILGPVGVGKTFLATALGHAAIRRRHSVHFERSDQLFKRLKASRLDLSHDAEIRKLIRVDLLILDDLCLQALDTTDTADLYELIVERHRQAATVVTSNRDPVEWLALMADGLLAQSAIDRLQSSAYELVLDGDSYRRRQKPTPGDPPQPPPTRRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI3</accession>
    <name>A0A7K0JPI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M24 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="167"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="389" mass="40173" checksum="E23C9D873046F552" modified="2021-04-07" version="1">MSDSLTNDQRRDAVAASFPVEDRWGRVRAVMAGQQLDRIIAVGSRYATWLTGYHRYFGGLTATLIDPTGGVEVVASPDEAPLVEAVTGAARIHVYGEGGFGLDLDPLGSLVAALPGLGVLGSGARVGVAGIAPVGLHGAGEADLVPVDEQLSRIMAVKDRDEAEKVAHAYNLCLEAQAAVNRGVQDGASELELFTRAHATAQLAHGAPVDFVSDLLSGPNSASVCCPVAVAGDRRPKRGDPVVADIAVSAAGYWGDTCRTHVRDDNEHLKALLGELASILGEAVAGLRPGVRASDAHAAMARSLAATFPEATPLPHHGGHGLGLGGCDSPHIIPRDDTTLEAGMILAIEPGAYFPGQYGIRLENEYLVTPAGGIELNEALASVMTGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL5</accession>
    <name>A0A7K0JPL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000152">
        <property type="protein sequence ID" value="MST31837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="23081" checksum="92844C7F707DFD27" modified="2021-04-07" version="1">MVRPQEATGPAAGNRTDGRRGEILAVATRLFARSGFHGVGMRAIAEAVGVQTSSLYHYFPSKTDILYAISRDATAAFIAAQSPRLEEAGAAPAETLRAVFSDHVRYFHAHREEEAVGLRELRELEPPRFEEINALRRGYQDAVRRVVAEGQRAGVFAVADPTLATLAVLGLLNSVNDWYRDGGPRTIDEVAEAYAGMAIERLLGAGPRGRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ5</accession>
    <name>A0A7K0JPQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000161">
        <property type="protein sequence ID" value="MST31877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="22764" checksum="A6AA4DC60DADE363" modified="2021-04-07" version="1">MTVTTDRTHAVAPSEIAVLSTPAPADPAPLGLAAFALTTFLISVWNAGWADAGSGAWIGYAFAYGGLCQLLAGMWEFRNRNVFGATAFSTYGGFWIGLALYIELVAPHDAAGVLSNDLGWILLAFAIFNTYMLMWSSFVNAGVFAVFLTLEATEILLFAGQFAGSKGLIEAGGYIGVLTALVAWYVSSAGVINGMTGRVMVPVGGPLAKPALRDPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX3</accession>
    <name>A0A7K0JPX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000191">
        <property type="protein sequence ID" value="MST31995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="405" mass="40456" checksum="4670737626D5FCFC" modified="2021-04-07" version="1">MALATRSSRRASGRRWLAVGVVVTILVLLIDASVRSRSPDPTRRLAGSVWADKVFALVQQSNVQGRELTAFLADTSPSSGAAVRLQLGDVRSGAASTLRAAQALGTPVAMSGVAGLLDTCLLVRSQEATAITGAVFHALAAPIGVGAITSASKVLAAGVQRLEVADAACALFAKDLPGWLHVRAPASQWIHGTGGPGTTPAGEAVFLTALHRRVNLKARSAVAIEAISTTPSAVGTRNGVQILTSGHQLTVDVVVGNTGNRPEQNLTLSASIAPATGTSTAHAYVGSLQPGTSDALTLSGLAPPIGRKVTLTVTLTPAAGDPAKPKTTTLEFEMPSPNSSVPTTSSTTTTSHKTTTSGSSGTTGTSGSTTTSTTGSTTTTTSGTSGTGVSGTGATGVSGTTTPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY0</accession>
    <name>A0A7K0JPY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligosaccharide flippase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_04625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="359"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="526" mass="55784" checksum="86F566AA51A4DCAE" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ41</accession>
    <name>A0A7K0JQ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000205">
        <property type="protein sequence ID" value="MST32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21505" checksum="C4FCB94A133FF015" modified="2021-04-07" version="1">MPRKSLEVRREEILAETARQLQERGLAGIRALDVARALGVSTGLIFYHFDTMERLLAATFDHAAQRDLEQLQTVLDGPGDALGRLWAVLDLYAPTGSAAGWMLWIDGWSAALRDDQLRAVVRRLDRRWKRAIAALVQEAAAAGALGTEVDPAGAATRITALLDGLAVQRLVRGDALSAGRLRSWVRAYARAELGLAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ43</accession>
    <name>A0A7K0JQ43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">GHK86_04930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000204">
        <property type="protein sequence ID" value="MST32070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="156"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="320" mass="34402" checksum="D90B70EFF0D15DEB" modified="2021-04-07" version="1">MLSVGDLGPAGIGEVLRLSDRFVEVSARPIPKVPALRGKTVASMFFEDSTRTRLSFETAARRLSADVLTFSAGSSSLNKGESLRDTVETLEAMGVDALVVRHKSSGVPWQVARWARRAAVVNGGDGWHEHPTQALLDCYTIRAERRDRGLGTDLAGLRIGIVGDIRHSRVARSDVLAFGALGAHVTLVAPPTLLPPSLDGWDVEVSHDLDGLLPKLDVVYLLRLQQERMTEALLPSLREYTATYGLTRQRAGRLAPGALVMHPGPVNRGVEIASEVADRSVITHQVANGVAVRMAVLFLLLGSGSTAAPTTREEVDRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ52</accession>
    <name>A0A7K0JQ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000209">
        <property type="protein sequence ID" value="MST32082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="2">
        <location>
            <begin position="157"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="37327" checksum="5A8E688537970540" modified="2021-04-07" version="1">GLRRGTDGDGGDDGARRLRAQQAALHLANDLDTILDPVEGSVAWVEGPEHTPTVRVAPLDVGEVLGRVLWSGEEAPTGILTSATVPPRLVERVGLPAGTTDELDVGSPFDYPHQALLYCAAHLPPPRDPRYEAAMLDELVALVQAAGGRTMALFTSYRAMTAASAAVAARVPWPVLTQGDLPKPALVARFAAEEQTCLFATMGFWQGVDVPGPSLSLVTIDRLPFPRPDDPLLEARRERLGRAAFELIDVPRAATLLAQGAGRLIRSSGDRGVVAVLDPRLATARYRWALVRALPPMRRTRHRAEVEQWLAPLHPPPPVPGGGGPPDYDAWTMPRGGPGSGHLTDRFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK3</accession>
    <name>A0A7K0JQK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000249">
        <property type="protein sequence ID" value="MST32228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="35986" checksum="06A5AB23D9ABD6C5" modified="2021-04-07" version="1" fragment="single">MLAALPQLLAAAVAVVNLVAVRATRLPVAYLDDADMHEQMVRFARQSFAAGRDPLTRWFPYLNEGSPQFLHYQSLGAMITGAIALVTGGDVAFRWSLYLLWALWPLAIYASARIFGLGRWASLAAAAVSPLLMSRTGVGYEVNGYLWIGYGLWAQLWGMLFLPFAWACTWRALADRRWTLPAVAAIAATVCAHFETGYLALVAPVLLVWLVPSDLRRRLVRAVVVLLLAFAAAAWAIVPLVVYRRWAAINEALAHGPLVNGYGARVVLGWLFGGEVFDNGRIAVVTILVAVGTVAALWRWRRDPLGRALVVLGVFSLMLCWGRTTWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ9</accession>
    <name>A0A7K0JQQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA</fullName>
            <ecNumber evidence="2">6.3.5.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gatA</name>
        <name evidence="2" type="ORF">GHK86_06030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000262">
        <property type="protein sequence ID" value="MST32280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="33043" checksum="97C18D35CCBAB8F4" modified="2021-04-07" version="1">MTVPRRWLVAVVVVCLAAGGIRQPAALCGVVGAKPTYGLVSRYGLIAFASSLDQIGPFATTVADAALLLDVIAGHDPADSTSLATSPPRAGAALDRGVDGLRIGLVSELASAEGLDPQVVARTREAADALAGAGAKVEEVSVPAAVYGLTAYYLIAPAEASSNLARYDGVRYGRREPGADITEMYLRTRSAGFGAEVKRRIMLGTYALSAGYYDAYYGKAQKVRTLIVRDFEAAYQRFDALLAPTAPGGAFPLGAKTADPLLMYLNDVCTIPSNLAGHPAISVPFGVDDAGLPLGVQVLAPALGETVMFQVAAALEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS0</accession>
    <name>A0A7K0JQS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029665762" evidence="1">
        <location>
            <begin position="38"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="322" mass="33235" checksum="32B51B894CC4F671" modified="2021-04-07" version="1">MRKPILAGAIVVVVALLSGCGSPSAVLGPVQVVTAKAAARFITVSADLPYVGYRVQLRSLSDGKVLGRLARSGPSHPLAATQETNGDVLVAETHGPCSADLYRVDPATGGVSVVRHVNHAISDLHVSPNGRSVGFMTYPICDSGHGPQAQAPPSALAVVDLATGTTTLTSTPTQLFSGVSWSPDSRRLVTSYTGTGALLILDARTPRLAAAHVIGPPSGCAFSFPSWTASGIITAATCGRTGYLEKLTPAGQLIHRWKVPACGLNGIQTTQDLPAARTLVATSSGPYHHCNGATQETFSILEPTGLHPVTAIIEAGNTSYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW9</accession>
    <name>A0A7K0JQW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000267">
        <property type="protein sequence ID" value="MST32307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="12230" checksum="174048949331D4FA" modified="2021-04-07" version="1">MATVRASCPSCGDVETTTRAVQVLRCATTGDAAYAFVCPACRLRVAKEATEHVVRILVDAGVPVVSWEMPAELAEPKVGARVTHDDLLAFHFALQEPGWLEQQVGILRAAARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY2</accession>
    <name>A0A7K0JQY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_06195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000268">
        <property type="protein sequence ID" value="MST32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="31823" checksum="8998746C927C9646" modified="2021-04-07" version="1">MTEAVDRLDGRLVEELQRDGRAPMEDIAAAIGLSRQATRTRFERLVARGALRVVGVVHPSAQGLHAFAHLSVFVRGSALRAARAIARLPTVPLVSIVAGRASLIAEVRAPDMAALHALIRTIGSVDGVAHVEAATYTERIKDRSSPALAVATPRLDAVDRALLDILQADGRAPYAQLGRRINYSASAARGRVQALVGSGAVRVTAIATPGLVGLSQMCGLGLRLTRADAAIAKLLELPAVSYLSLAVGRWDAVATLLVASPAEVVAETDRIRALRGVDSLESWTHLQVVKEDYRLQLAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ2</accession>
    <name>A0A7K0JQZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_06425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="22204" checksum="5188845F18A543D4" modified="2021-04-07" version="1">MHEDGSDRRPQRGRPRSEKADRAILDAAAALLAERGVADMSIEEVAARSGVAKTTIYRRWSSKGSLALDAFVDRFLRLQPLPDTGSLRSDLLRALRAWRRAVLEPETARSLTGLIAAAQDDPDLAAAWRQRVVEPIRGQWRTMFERAVERGEIPGDADVEVAIDVLFGPAYHRLLNGHLPITEGFVRAVVDYVVAGLGARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR64</accession>
    <name>A0A7K0JR64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="143"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="363" mass="41466" checksum="201F290D39BEC147" modified="2021-04-07" version="1">MAGTVPSERREQLSCELNAQIEAFAGRVGVGRACRAFGVPPRSWRHRRQAVEGRLPLRAPREPRPRPVPPWTLPEDERDRIRDLLCSPRFCDLAPAQVFNTLLDEGVYVCSESTMYRILRADKLSSERRRGHRRHRHAPPVLRATGPNQCWTWDISYLRGPARRVWFYLYAVIDMYSRKIVAWCVDTVESDKTARRLIATACQREHVAADTLIVHSDRGAPMTSHTLAELFETLGVTRSLSRPRTSNDNPYSEATFKTVKYRPDYPDRFETIDDARSWMRRFVYWHNHVHYHSGIGGHHPAAVHDGTARHTTRARQAVLDAAYTANPARFHNRPPTATPPPAVAWINKPTIHTKTGHTPATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA1</accession>
    <name>A0A7K0JRA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000300">
        <property type="protein sequence ID" value="MST32460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="358" mass="37328" checksum="B7F0C9BBC6579D66" modified="2021-04-07" version="1">MPATGAVRSGSSPARRRDPTTAAVRENPVRGAPRPARPAPRRRRSPAPGTPRSADRPPRRCHQQVGAEVRYDTARTRGTMTAIRVVTDSACDLPDTLLTELGVGLVPLHIRFGAEELVDRTELSTKEFWARTAAAAALPETSAPSPGAFHQAFERMAAEGATGVVCVNLSSRLSATIEAARQAANEVAPGLPVRVVDSRSVTMGEGLVVVEAAERAASGGSLDEVAAAAEASVSHLKVYGVIDTLDNLRRGGRIGGAAALLGSMLAIKPVIEVRDGVVEQESKQRTRARSLRYLADKVRAAGPLRRFAVFGADAADFDAFLGLLADVPSASARLVGDIGPVIGTHAGPGAVGVAWLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD0</accession>
    <name>A0A7K0JRD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000311">
        <property type="protein sequence ID" value="MST32490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="327"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="505"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="569" mass="59959" checksum="50805CB37C96CA66" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD2</accession>
    <name>A0A7K0JRD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000312">
        <property type="protein sequence ID" value="MST32495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="434" mass="41582" checksum="4B91079E23A48017" modified="2021-04-07" version="1">ALLAAGALIVGGAGVGIGAGLDSTSQPSATAPSGSGGTGSSGGSFGSGPSGGSFGSGSSGSSGSGGFGVPGASGTSGRSVTTSAGSPSNVTAIAKKVDPGLVDINTQLAYQSEQAAGTGMVLTSNGEVLTNNHVIEGETALSVTDLGNGRTYRAKVVGYDRTDDVAILQLQHASGLSTVKIGNSSPLRTGEPVVGIGNAGGAGGAPSVAGGSITALNQSIKASDQGSGTTETLHGLIQTNADIRPGDSGGPLVTADGRVVGIDTAALSNGSFTFQTPSTSANQGYSIPINKAMRIAHQIEAGRSSSQIHIGPTPFLGVEVTTPTQLYSAGASSGLGGFGGFGLGASGTSGTPTTPPTTSGAAIANVLPGTSAATAGLSSGDIITSIDGKSVTSPAGLTKQILQLRTGQSVSLGYVTSSGAQHSTTIALKAGPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD3</accession>
    <name>A0A7K0JRD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sigma70_r4_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="7857" checksum="9FB68F7ECD02FCE3" modified="2021-04-07" version="1">MTPSPPRRLAPNDASGQRPGRQRDAVALRYVADLSVEDTAKVMGCAPGTVKALTHQALAAMRIRLREEADDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF6</accession>
    <name>A0A7K0JRF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000322">
        <property type="protein sequence ID" value="MST32528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="12221" checksum="893A08E34D276E37" modified="2021-04-07" version="1" fragment="single">MAAGEAPPVVPAVSRSARQWGMVGALGAAVGWGLAGVFVVLAATPGLVIVLYRMWLGAALLVAALRASGRRLTWRAIRIAAPGGVLLFADMTLFFDSLRLTSVAVATVIGALQPLLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN5</accession>
    <name>A0A7K0JRN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_07535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000333">
        <property type="protein sequence ID" value="MST32573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="321" mass="34655" checksum="45581626E2031A17" modified="2021-04-07" version="1" fragment="single">MRRRPTATSAFGVSRREGHDASGFYRRFQPPEVSADATVAAHRAVDKLIVGDARKMSEVPDASVALVVTSPPYFAGKAYEEALGERGVPATYLEYLDLLRDVFAECVRTLEPGGRIAVNVANLGRRPYRSLAADVIGILQDDLRLLLRGEIIWLKQRGSSGSCAWGSFQSPANPVLRDLTERVIVAGKGRFDRAMPARARARAGLPSEASLTRDAFMEGTLDVWEIPTESATRVGHPAPFPVELPARLIDLYTYRGDLVLDPFLGSGSTAVAARRAGRHYVGYDLDGAYVALAEERVAAEPERPAGVPGDPGADALTRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW1</accession>
    <name>A0A7K0JRW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000362">
        <property type="protein sequence ID" value="MST32686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="11471" checksum="2843D1344FD182F4" modified="2021-04-07" version="1">MNSSDVDSSSAGGTDSTIVAGGPGLSTRAGWPRPHLTERELQVLQCLPTRLSVDEVAAALSISPNTVKTHLRSIYHKLGARSRNEAILIGCEQRLVSERSRWVLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY3</accession>
    <name>A0A7K0JRY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="197" mass="21663" checksum="89C6FF1D8A95F760" modified="2021-04-07" version="1">MNDALAGTPLRGRYWLDGGLLLGWARAGDALANDLRDVDFGVLAEDFPRLVAAVPTLEAAGFSMLHVVRAPDGEPLSAHFARRGVQFDFIKAVPRDGKLLLRGTAEVPSLVTYERPHLALGSFHLFGREWLKPEDHEAALAAHYGNWRADWRKDWSTPRDSPSVVAVEPSAEWRRASVRPVQELPSPAAVDTVGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS47</accession>
    <name>A0A7K0JS47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000376">
        <property type="protein sequence ID" value="MST32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="373" mass="36803" checksum="2F57EF6EAF40D8BC" modified="2021-04-07" version="1">MPVQVDAQATTAGVDVVVHGLPGTITGTVVTGMVPAPPVTVQLEALQGNTTTPIRTVQAHGGHYTLTGIPTPGLYQLLFTATGYHFADDQEQLAGGAHDVANTVTLSAAAGGIQGQVTAAGRPLGGVAITAKGDGRTYRTTTPTQGAVGQYVLVGLPSPATYLLSFSEAGYGTVTEAERLGPGQELTLDASLAGGAGTIAGRVTSAGGAPLGDVAVTVTGGGTTVTTQTFSDQQTDAGQYDVTGLTTPGTYLLTFSAPGYVSQTIQVALTAGQAVSGKDVTLQTSAATIVGDVVDGSTGLPLGGVKVQLTNGVTTQATTSATGPPGKFAFTALAAGSYTLTFTLAGYAPATYVVTVPSGGTATVTAQLEPAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS60</accession>
    <name>A0A7K0JS60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000385">
        <property type="protein sequence ID" value="MST32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="421" mass="46008" checksum="84C37327C34C7398" modified="2021-04-07" version="1">MAADPSLLVDGAFWRRPLADRMQVFAEWRAEGPFVPAHVEVPFFGQSVDFTAVIGHPEVAEISRRPQEFCSGRGSTAIVDLPVDALEYFSSIIVMDDPRHARQRGIVARKFTPRHLQTLLDSVERVCTEVLDGVCEQGEVDLVETVSEPFPLLIICDMLGIPRSEFATVLRCTNVILGAGDLEATGSEDVFTALLSAGMELTGLLNELVEHRRQHPADDLTSALVHTDVGEDWLRPEELAPFFILLTTAGNDTTRNAISHGVDLLARHPDQKAAWQADLGGVTASAVEEILRLASPVVYMRRTATRDTTLAGVDFREGDKVAMFYGAANRDPRVFADPEAMDVRRAPNPHLAFGGPGPHFCLGAHLARRELAVMFRQLLTRLPDLEPAGEPQLLESQSIPLVGGVKHLPVRFTPAPKVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS93</accession>
    <name>A0A7K0JS93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000290">
        <property type="protein sequence ID" value="MST32434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="335" mass="34406" checksum="83B9315799FA5FAC" modified="2021-04-07" version="1">MPEAYPAHRATQPARVVRAPAIGTSSQDERNKRFIVAARRVRPGAVTAPQPKEERSMANDTTPRPGGTTVGAAATGTGGGVGSTGGSGGAATRRPYEDLMVAEDAEAWRARTRIVLMPTAPPSIMGLMGFTIATLMLGSWQAGWWGTGSSPLGFWPLALVAGGILQSIAAVVSFRARDGAAVAVHTAWGAFWIAWGIVELLVALHVTAPVALGSTAPAFAIWFVGLAIVTLSGFLAALAQSVLLAITTGTLAAGAALTAVGFFTGSLGLDYTGGWLFVVAAAAAWLTATAMILEGATGRTIIPLGKWKKNANIPGRMATVPMQYAEGMPGSRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA2</accession>
    <name>A0A7K0JSA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000395">
        <property type="protein sequence ID" value="MST32810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="15531" checksum="D09559BDC07189AA" modified="2021-04-07" version="1">LQAARRRQGDMSDTVVVAVDGSAHTDKVLDAAAAYARQTELPVVVVHVRELEGVGKAGAVWREEREETAEIAARAVEHVKAQGVVADAVTASAGIGHVARAVADIARDRQARIVVVGTRGHGQIAGLLLGSTATKLLHLMDRPILVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB4</accession>
    <name>A0A7K0JSB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000298">
        <property type="protein sequence ID" value="MST32454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="26017" checksum="6BCC834DA26CC86E" modified="2021-04-07" version="1">LERARALAAEALEADPSDVVLTDDGRLGVAGVPARALAWSELATRAADAGEALAVALDQRQEAATFPFGAHVAVVEVDRETGSARPLRHVAVDDCGRILNPLIVTGQQHGGIAQGTAQALWEQMVYDADGTPLTTTLADYAMPSAAELPSFETFNTETPTPLNPLGAKGIGESGTIGATPAVHNAVVDALAHLGVRHVDMPCTPERVWRAIRSAEAGTPEPAWRTPPDVFSDLPVRGEQDEPEAAGADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC2</accession>
    <name>A0A7K0JSC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000403">
        <property type="protein sequence ID" value="MST32835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="9808" checksum="72981C597ED4690D" modified="2021-04-07" version="1">MSISASEARSRLFPLIQQVNDDHLPVRINSKGGDAVLMAAADFDSWQETIYLLRSPANARRLMEAVERDKSGHAAVVKTLEDLQDLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC8</accession>
    <name>A0A7K0JSC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate, phosphate dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000402">
        <property type="protein sequence ID" value="MST32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="1">
        <location>
            <begin position="315"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="43271" checksum="234843840137CF77" modified="2021-04-07" version="1" fragment="single">MTSGVESPPLPAGRIALLGETGLDQVSPGSVGAKAYNLFRMADAGIPVPPLFVLGTATGRELGRPRGLRREDLAGLVRAGVHHLERATRLGFGAGRHPLLLAVRSGAAVSMPGMLETLLDVGLDDTTLPGLLRATGDPVFVWDSYRRLVQTYAEVVDDLPPGPFAAVVEAACAREGVASASELDADATRHVVHELRERYRDAARRDFPQDPMEQLLGAVGAVLRSWDSPRAATYRRLQGLGDLTGTAVTVQAMVFGNLGVTSGAGVGFSRDPATGRDELYVDFLLDAQGEDVVAGRQRAGDADAALAAVPGLRHRLRSTARTLEGLFGDAQDFEFTVQEGVLWLLQSRSAKRTPWAALQIACDLVDEGLLPPAVARQRLAGYDLEAIVRVRLDPAAAASAVPVAEATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH4</accession>
    <name>A0A7K0JSH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_09095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000416">
        <property type="protein sequence ID" value="MST32873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="359" mass="36432" checksum="3D4F2F968522B811" modified="2021-04-07" version="1">MRAAVCRGFGEPLAVEELELAAPGPDEVRVDIAACAVCHSDVTFADGAWGGTLPAVYGHEAAGRVSEVGPGVTAVAPGDPVVVTLIRSCGRCWACRRGDPVLCAASFPLDERSPLTDASGAPVGHGLRTAAFAEQVVVHVSQLAAVPEELPLDAASLLACGVITGAGAVLNTARVEPGATVVVIGIGGVGVNAVQGARIAGAERIVAVDLVEEKLALAGRFGATDTVAAGSTDVAAAVRELTDGRGADYVFASVGAGPVMEQAVGLCRRGGTAVMVGIPGNGVRLDLDGIAIPNDGLRILGSKMGSARLAEDIPRMLGHWARGELLLEELISSRHPLEGINDAFDEVRRGGALRSVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP7</accession>
    <name>A0A7K0JSP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="7" type="ORF">GHK86_09590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="136"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="380"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="587" mass="61353" checksum="578E4800D812CC32" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY1</accession>
    <name>A0A7K0JSY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosyl pyrophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_07830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000346">
        <property type="protein sequence ID" value="MST32629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="331" mass="35960" checksum="937BBE8E5BBCA92E" modified="2021-04-07" version="1">MIELVTTRKLQLLSGRTHPALAEAIAADLDVPLADPKLVDFANGEIRPRFADSVRGADVFVLQSHGRTPGRSVNDSLVEHWIMIDAAKRASAKRITAVCPYYGYSRQDRKSKSREPITARMVADFFRAAGADRIISVDLHAGQIQGFFDGPVDHLTATPLLTDYLRTHAPSGDFVMVSPDTGRSKVAEQAARFAGEQVDVASVYKRRAKDVVNQVEALDVMGDVEGRHCVLIDDMIDTAGTICAAADLLMEKGATEVWAMCTHAVLSDPAVDRLKNSVISRVVVTDTLPLPPEKQIDKLEVVSVASIFAEAIDAVFCDRSVSEIFGGENQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT46</accession>
    <name>A0A7K0JT46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="7" type="ORF">GHK86_10395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000492">
        <property type="protein sequence ID" value="MST33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="399" mass="43318" checksum="9DC644EAB04089A9" modified="2021-04-07" version="1">MLAYVGDPVFSRGLTIGVWGIVLVKVVAIFVIVLLSVLFMVMYERKAVAWLGVRYGPNRAGPGGWLQSLADGTKLFFKEAFTPVRADKWVYKAAPYLAVVPAFVAFSIVPIGGTIHLFGHSTRLQLADPPWGILLLLMTSGIGVYGVMLAGWSSGSKYPLLGSVRASAQMVSYEAVLGLTTATVVLMTGSLHTSTIWLSQHGPTLYHWNFIRTGFIPFALFSIAITAEMTRAPFDLVEAEEELAGGFNLEYSSIGFAFFYLAEYMNLVTNSAIIVTLWFGGPDGPGVAYSGWIGLIWFALKTLIILYVFVWIRATLPRVRYDQLMELGWKRLIPGALAMLLIVAGFRVKWTWGLVAVGGSLLAFAVLLRAVDVGSTASAVDVRSEEALTGEPATGVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT80</accession>
    <name>A0A7K0JT80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000391">
        <property type="protein sequence ID" value="MST32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="42050" checksum="725A8C7328BDE86C" modified="2021-04-07" version="1">MTLTDEAASRSSELSELRHALHQEPELGLHLPGTQRRVLDALAGLPLEVTPGDELTSVTAVLRGARPGPTVLLRGDMDALPLREAVDVPYRSRVDGAMHACGHDLHTTMLVGAAHLLAGHREEMAGNVVLMFQPGEEGFDGAGAMIREGVLDAAGERPIAAYALHVFSSTWPHGTFATKPGPIMAASDVLTVTLHGAGGHGSAPHKAKDPIPAAAELTLGLQTFLTRTVDPLDPAVITVGSLHAGNRYNIIPDTAELVATVRTFDPEVRRIIMEGAQRVSDGIAAAHRLRAEVRFEAQYPVTVNAGAESAFVGETVRELFGGDRYVEMPRPITGAEDFSRVIDAVPGAMIFLGAMAPGTEGEPHPDNHSASAAFDDRVLPDGAALYAELALRRLATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH6</accession>
    <name>A0A7K0JTH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000424">
        <property type="protein sequence ID" value="MST32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="141"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="479" mass="53189" checksum="92D3F3AFDA2301D9" modified="2021-04-07" version="1" fragment="single">MALSFREVGVHEVREVLRLWLRGESERENARLARVDRKTVNRYVTAGIEAGLVCDGGEGQLTDGLIAAVCERVRPHRPDSHGAGWAMLRAHHEQLKVWLVDEGLTVVKAHELLARQGVVVAQRSVHRYALEVLGVGRSARRSTVPVADGEPGAELQVDFGKMGLLVDTVTQRRRVCWALILTACYSRHCFVWLSFTQTTEAVIAGFEAAWGFFGGVFKVVIPDNMSSAITTADKLEPRFNQAFIEYAQARGFVVDPARVRSPQDKPRVERTVPFVRNSFFAGETFVDLADAQRRAVQWCMVRAGQRVHGTHACRPVELFDLEERPRLLPAPGSRYDLPIYATAKVHRDHHIEVARALYSIPGNLIGAPVEVRADSQLVRVFHRGALIKVHPRQAPGRRVTDPADLPAERTVYAMRDLDHLRRLAAAEGPAIGAYASALLDTPLPWTKMRQVYALLGLVKRWGAPTVEAACARALDAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN0</accession>
    <name>A0A7K0JTN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000547">
        <property type="protein sequence ID" value="MST33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="15589" checksum="9BB6628E8E56DAB5" modified="2021-04-07" version="1">MVRRERSGTGDDGFVGGFEGLLFGVLIFVAGGLLVAAVWATVDTKLAVADAARVAARTYVEAGDSGSAAMESVAAADTSLQGWGLAPRRATVQRASGSWARCSRVTIVVRYPAPALELPWIGRVGDGRDVSAAVSELVDPLRSGLPGVATCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN9</accession>
    <name>A0A7K0JTN9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prok-JAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_11350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000556">
        <property type="protein sequence ID" value="MST33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10975" checksum="E341959E6E260E04" modified="2021-04-07" version="1">MAERCYPATNAAGSSRVYTVEPRDLLRADREEEAAGGELIGVWHSHTHTEAWPSPTDVGQAPDPGWHYVLVSLRDVEPTLRSFRIRDGNIFEESVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV8</accession>
    <name>A0A7K0JTV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="12631" checksum="6DAF2E01A011C574" modified="2021-04-07" version="1">MKYLVDLTRLADQLETAGHDAVHAASRSLHAAPDEAVLDVARAEGRVLVSADSDVGTILAASRATRPSVLHLRDTTGRRVAQLAQRISAALPSIEEALTSGSPVVIEPTLIRIRPLPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW8</accession>
    <name>A0A7K0JTW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="17697" checksum="8F27386EA4D62D06" modified="2021-04-07" version="1">MNVVEDVPWLDEREERAWRALQFMHLRLDGELARQLAADAGLSYPDYVVLVALTDQTEGRMRLFELAETLGWEKSRVSHQVSRMAERGLVKKEKCGSDRRGAHVVATSRGRCELEAAAPGHVEAVRRHFIDRLTPEQLEVIAAAAEAVLDGFDSTTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY9</accession>
    <name>A0A7K0JTY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000580">
        <property type="protein sequence ID" value="MST33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21592" checksum="BFE54AF84AFDEDCB" modified="2021-04-07" version="1">MSDDKIRRGKTSPPPTPLSPGASAPLAGIAEAVGQPTPRARLDPIDVRLLGLLAADARVSQRALARELHMSPPAIGERIARLERAGVIRGYTVDIDWTALGYGTRVYLAVTANTDRGRILSALHAIPEVEGIAVVTGSMDLLARVRVRDHEHLRQLLFERVWTIDGVERTETYLCLAEMPAKDFAGELLATMIDEEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU35</accession>
    <name>A0A7K0JU35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">GHK86_12065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000599">
        <property type="protein sequence ID" value="MST33451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="363"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="553" mass="59365" checksum="1302A114C2D0B76B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB0</accession>
    <name>A0A7K0JUB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000624">
        <property type="protein sequence ID" value="MST33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="27391" checksum="A592C7D4A7B134EF" modified="2021-04-07" version="1">MTTVASAQLSLSVGDVAANRDAGLAAIDEAAAAGASLIVLPELSDTGYVMRSPDEAAALADHEGTLGAWAAAAARTGMVVVGGLCVADGDGTLRNAAAVVDPTGVRALYRKAHLWDAEPDLFTAGDDPPPVVDTAAGRVAVMVCYDLEFPDWVRKAATAGADILAAPVNWPKLADPPPGERPAEVIKAQAAAATNGVWVIVADRCGVERGVDWVGGSVVVDPDGYPVAGPAGSGRPALLLADIDPARARDKALGPRNDRFADRRPALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS3</accession>
    <name>A0A7K0JUS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000695">
        <property type="protein sequence ID" value="MST33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="12157" checksum="8F9010CE957E491C" modified="2021-04-07" version="1">MDRTQPQTLYMATILLYLNAALAILTALIYHNLGGLIGLVFLAGEIAGGWGIANEKKWGFWVAAVVSVLILLLALAFFSFGNIINLVFDIALVALLFHPQSTAYRKTWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS4</accession>
    <name>A0A7K0JUS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000687">
        <property type="protein sequence ID" value="MST33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="300" mass="32193" checksum="4CC72D98CC588FF3" modified="2021-04-07" version="1">MTQRLETMSGALAPVASVVVAVYNGGEQLGAQVAALLGQSLSNLEVILADNGSSDGCVEPFVGIGKIRVVDASGKRGQGFARNVGAAVARSDYLLFCDQDDVAEPGWAEALVEALLRYDLVGGSFDVGSLNSGVEFWRTPPVRADVGSPLPFASGSNFGIRREVLNAVGGWPERYLGGGEDTALCWRAQLAGYTLGYAPRAVMQYRYRRGFGAHVKQQFHYGRQAAVVSRDFAELDDMPVAPIMRTLGWLAVNVGLLAKPESRGGWMGVAARRAGYEVGRRSARSIVGLATQRSRRREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV2</accession>
    <name>A0A7K0JUV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000703">
        <property type="protein sequence ID" value="MST33730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="543" mass="55960" checksum="11EAF1CA2B2971D3" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ0</accession>
    <name>A0A7K0JUZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_13635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000711">
        <property type="protein sequence ID" value="MST33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="481" mass="50148" checksum="7622C83E3340DAE9" modified="2021-04-07" version="1">MTAATPEPTYRFGRRSTRGLILGFSAPRAAAVGVAVGLAVAGLFTAGAAGLAVTAAVWAPLAASAFVRIGGRPAVEWAATAGHWELRKATGQTEYRSRLPHSPRPPGTLALPGDAAPLRFHQDPASGAVMVHDPHRQTLTAAVSVTHPAFVLLDSDDRAARVARWGRVYAMLAHSGTIAALQVLEETVADPATGQTDWYATRGVHDGSWPDQQYRALLDQVRLGAGTHRSTVAVSLDLRAAGRAVKAAGGGVPGGAAVLRADMANLADALRQAGLSVGAWLDEPHLAAAIRGAYDPAATVQAGGPGAHLANAGPLAVSESWDRLRHDSGHSAVLWIAEWPRIEVAADFLHAVVFAPDIRRSLSITARPLPTGDALRQLRRDKTDAVADAAQKAKIGQLADLSDSQEYEDLLARERSVVAGHTDVEFAGFVTVTAPGLDALEAAVAAVTRAGAQAACELRPLYGRQAQGFAAAALPLARRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV27</accession>
    <name>A0A7K0JV27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000584">
        <property type="protein sequence ID" value="MST33414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="26687" checksum="A1B446A478C81C16" modified="2021-04-07" version="1" fragment="single">MTDEADRVTVGVGIPTCSYERAEDLATCLEGINSGSRRPARIVVSVDSNPLLARHLARRPDVGQQADVVVVDGAGVGVSEARNEAAAAVGTDIVLFIDDDVRPHQRWVEGMVSALVQPGVVAAGGRVLPVYESPRRRLPPELLWLVGCTYAGHADGPGPISRPIGAAMGFWRDRLLEVGGFNARFGPRRGRKASSNEELELAVRLREAYGDEAIRYQPHAIVFHKVPEQRCTWRYLTQRCWVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB2</accession>
    <name>A0A7K0JVB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000765">
        <property type="protein sequence ID" value="MST33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6438" checksum="7ABEA1658854BB1F" modified="2021-04-07" version="1" fragment="single">MRAAVLFAEKQPLEVVDVELSGPGPGEVRVRLAATGICASDWHTMTGAIPSPTPSVLGHEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB9</accession>
    <name>A0A7K0JVB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000743">
        <property type="protein sequence ID" value="MST33842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="44931" checksum="5C9537347FA513D0" modified="2021-04-07" version="1">MAELEQETEPEKVGLSAERLARIEGHFARYVDDGRLAGWLAAVTRRGQVAYVARRGDRDREAGTPVEVDTLWRWYSMTKPVTSVAAMMLYEEGAFDLRDPVSRWIPSLADPQVYVAGPPARPVTRPAAEPIRVWHLLTHTAGLTYGFHHVHPVDAIYRAAGFEWGHPRGMDLAACVDAWAALPLLFDPGSEWAYSVATDVLGRLVEVVSGQSLDEFFRTRIFEPLGMRDTAFWVDEAGADRVAALYTAHPRTRLATPADGSAALSRHRMLSGGGGLVGSARDYHRFTQMLLRGGELDGVRLLGARTVSYMATNHLPGRQDLERFGRKLFAETSYDGIGFGLGFSVTDDPAAAKVLGSAGEYGWGGAASTVFWVDPAEELTVLFFTQLMPSSTHPIRPELKALVYQALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK4</accession>
    <name>A0A7K0JVK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000799">
        <property type="protein sequence ID" value="MST33987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="389" mass="43583" checksum="0E3A185B54BE803B" modified="2021-04-07" version="1">MRILVLGGDGYLGWPTALYLSARGHEVGVCDNLVRRDYDKEMGVSSLVPIASIEDRVAAWGEQSGAKLATYVGDLTDAAFVHRMVREFEPDTIVHFAEQRSAPYSMIDQAHAVYTQTNNVVGNLNVLYAIGDINRDIHLVKLGTMGEYGYPNIDIEEGWIEITHNGRTDTMLYPKKPGSFYHLSKVHDSHNIEFACRTWDLRATDLNQGIVYGQQTEETDADPRLATRYDYDAVFGTVLNRFVIQAVLGHPLTVYGEGGQTRGFLNILDTIECIRIASENPANRGEFRVFNQFTESFSVLELAEAVKKAYPGEVTVEHTANPRVEAEQHYYNAKHTKLVDLGLQPHLLNETLIDSLFHVVEKHKGGVNLDAIRPTVQWRSTASELSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK5</accession>
    <name>A0A7K0JVK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000776">
        <property type="protein sequence ID" value="MST33932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="12727" checksum="AAC0B37FD03AF22F" modified="2021-04-07" version="1">LTASDRPIPGSTDLYGRGPGRVVHDELDLPVGKLQVKAGGGLAGHNGLRSIKAHLHSDAFTRVRIGIGKPPGGKDRGADHVLRPPGKRERNELDVTIEQAADAVECILADGVLAAQNRFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP5</accession>
    <name>A0A7K0JVP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="644" mass="68602" checksum="A3F5B7F58D1D001D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV6</accession>
    <name>A0A7K0JVV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_13195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000685">
        <property type="protein sequence ID" value="MST33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="27635" checksum="143B34B721F6C3CE" modified="2021-04-07" version="1" fragment="single">MNLTLHVWRQSGPSDAGRMVTIDAPGISTEMSFLEMLDVVNERLTLAGDEPIAFEHDCREGICGSCGMMVNGVAHGPQRATTVCQLHMRFFHDGQELWIEPWRAEPFPVIKDLVVDRRAFDKVIQAGGYITAPTGTAPDANAIPVPKPDADAAFEAANCIGCGACVAACPNASAMLFTAAKVTHLGLLPQGQAERDSRVLSMIATHDSLGFGSCTNIGECSAACPKEIPLEAIARLNGDLLRAARRRRRRAPRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY7</accession>
    <name>A0A7K0JVY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine racemase</fullName>
            <ecNumber evidence="4">5.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000828">
        <property type="protein sequence ID" value="MST34052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="3">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="11066" checksum="C69D26E505EF65CD" modified="2021-04-07" version="1">APAGGRRVGIVPAGYHDGVPRSASNAGVVVVAGVRCPIVGRVSMDSMAVDLTSCPEARVGTDVLVYGRQHDWSLPVEELAQSSGTIAHELMARLGPRVQRILTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ6</accession>
    <name>A0A7K0JVZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000860">
        <property type="protein sequence ID" value="MST34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="16276" checksum="4AA6815FD1395DAB" modified="2021-04-07" version="1">GGLALVCASDVRLAASTARFAVSFVRVGLSGCDIGTSWLLPRLVGAGRAHELMLTGRLFDAAEAERIGLVTSVVPDAELLEAAYREAELILGNAPFGVEMTKQTMWAALEAPSLPAAVALENRTQVLCLGGDDFAEAVAAFRGRRPPRWAPAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW25</accession>
    <name>A0A7K0JW25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)H-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000842">
        <property type="protein sequence ID" value="MST34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="6987" checksum="125D06BBB1EB978F" modified="2021-04-07" version="1" fragment="single">MRAVTIVEGRVEVREHPDPAPGAGQLLVRVRAAGLNGADVLQVAGHYPPPPGYPPEIPGLELAGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW58</accession>
    <name>A0A7K0JW58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphate kinase 2</fullName>
            <ecNumber evidence="6">2.7.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk2</name>
        <name evidence="6" type="ORF">GHK86_15810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000888">
        <property type="protein sequence ID" value="MST34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="29473" checksum="25883927CE38646B" modified="2021-04-07" version="1">MKRKEYEQALRRLHGELVSMQEWVKATGAKVCILFEGRDTAGKGGTIKALTARVSPRVFRVIALPAPTDRERSQMYMQRYLPHLPAAGEVVVFDRSWYNRAGVERVMGFCSAEDVDRFLRGTAEVERAMVDSGIILLKYWLDVSQAEQTRRLESRIEDPRKVWKLSELDLESYRRWYDYSRARDDMFAATHTAWAPWNVAVSDDKRRCRLNVISHLLGSVPYSPLEIRPVELPERQDAEGYREPRPVATPVPALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ9</accession>
    <name>A0A7K0JWJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000942">
        <property type="protein sequence ID" value="MST34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029757720" evidence="1">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="26623" checksum="7CC8637FBDAA2863" modified="2021-04-07" version="1" fragment="single">MAASVGAVLLLLGALPAVPAQATPAWTASWTVAMSGGLGQYAYDATVRQVAPLSVGGREVRAQISNQYGDAPLTVAAATVALAGSGSAVVAGTLHPLTFGGATSVTIPVGASAYSDAVAMLVHAGQRLAVSVYVAGGDSITEHYDAGDGVSYASIEGGGNLSGDVSGAGLAFPQTWDRFVSAVDVSGGATPPHATVVLGDSISDGYNFHCPGEQADCTLTTAWPTVLARRLRSLPAAERVGIANEAITANTVLPLADDDSRTGGGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ9</accession>
    <name>A0A7K0JWZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rossman fold protein, TIGR00730 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001026">
        <property type="protein sequence ID" value="MST34478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="357" mass="39467" checksum="8BB346FA8770E30A" modified="2021-04-07" version="1">MSRPRSGRQRGSGDPDLDERLEDLLDAAGVSANRDQLRDLLVTVVRLASDRSDRLDLKIANAALREMADGFELFAPYRAVRKITMFGSARTAASDPLYAQARDLAALLAAHHWSTVTGAGPGIMAAGLEGAGPDHAFGINIRLPFEQGANEFIASDPKLVSMKYFFTRKLLLIKESYGYAVLPGGFGTLDEAFELLTLLQTGKAEPAPVVLLDVPGGTYWHGWEEFVVQQVAARNLIADHDRRLYRIVDNVDDAAAEILGFYRNFHSLRWVGDTLVIRLERRPTEEEATELTDRFGDIVRGAITVLDRPLAAERRADEFAGLARVALRFDRLSYARLRDLIDALNVLDSAPPPVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX04</accession>
    <name>A0A7K0JX04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000840">
        <property type="protein sequence ID" value="MST34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="387" mass="39594" checksum="856DC4E0BA1155B0" modified="2021-04-07" version="1">SVVTAACGVAAAGWTAARVRAPRRLLGFAVSGELFAVGLSAVSHALAADLLGRATTAAVPAMVLLAGTLPLALAATVELGRAIEVVVVDTARGRQRSELVESQLEAMRRLEKGRNHDLNATLGAVSAALLLLQGPHAIDDPDEARRVAVAAQEQILWLQSQLVAEAGPPRWFQVGDVIERTVAIRRGQVQRIVTSIEPGLVAWGRPDHFALTLNNLLANAAAYAPDSPVAVQAHRVLVGDKAGVQVLVTDHGPGVRDPAKALTPGWRGTTIRRTTGSGLGLSQCKAMVEADMGRFALHPTDPSLPLGQQGLTVEVVLRGLDDAGDVGAGPTGGASGPPRGGVDGAATGGPNNGPPPGAGARSSWGADAAGATGRSDGPVQPSRRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX54</accession>
    <name>A0A7K0JX54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_17630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001058">
        <property type="protein sequence ID" value="MST34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="3">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="4">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="17957" checksum="52637A334C62C1C1" modified="2021-04-07" version="1" fragment="single">MAQTATLRALAEPLLRGSGLELWDVEVARDVVRFLVDRDGGVDLEALGEASRVLSGLLDEHDELVPSGQYQLEISSPGLERTLRTPDQYRRYVGTPVSVKTTQPVHGGRRHRGVLAAVTGDGVDLSPDDAPGEVRHLAFAEIERARTVFVWEPTPKPGGARAGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE5</accession>
    <name>A0A7K0JXE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001067">
        <property type="protein sequence ID" value="MST34552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="20079" checksum="58A3576B6E88823B" modified="2021-04-07" version="1">MLYYWDTVVEWHGPAGWEALSTFDEADGPLEEPGIVAGWRPVVVCGTNEALRRRLASAGVTALGWVDDMAALMADADVLVDNAGGLTSKEALAAGLPVVVFRPIAGHGRDDAMAMAALGVSVVVDDARYLVPVLDRVSRPGHLREEQVRRGLDLFGGDAADQLLALLADLGRPPAGAGSTASAARGSLPAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH3</accession>
    <name>A0A7K0JXH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ilvC</name>
        <name evidence="12" type="ORF">GHK86_18230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001126">
        <property type="protein sequence ID" value="MST34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="342" mass="35927" checksum="B2951EB85B79331C" modified="2021-04-07" version="1">MPATIYYAADADPSLIAGKKVAVIGYGSQGHAHALNLRDSGVDVRVGLREGSGSRAKAEAAGLPVASIADAAAEADVIVLLAPDTDQPAIFEESIVPHLSDGKAVLFAHGFAVRFGLISAPAGVDVIMVAPKGPGHLVRRTYVGGGGVPALIAVDQDATGTAKALALSYADAIGGTRAGVLETTFAEETETDLFGEQVVLCGGLTALIQAGFETLVEAGYEPESAYFECLHEMKLIVDLLYEHGISGMRYSISTTAEYGDLTRGPRIVSEGVRAEMRQILEEIRSGKFAEEWVAEYRAGLPNFKRLEAEGQAHPIEEVGARLRSMMPFINAGSSRPQDVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI2</accession>
    <name>A0A7K0JXI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001129">
        <property type="protein sequence ID" value="MST34657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="14739" checksum="279FEABAC7DD3C3E" modified="2021-04-07" version="1" fragment="single">VVLAGRDPAALDDAAATVRTAGAGRVETLPFDALDPAGHDAVLDRAGDLVGDLDVVVLAFGVLGDQARDEQGGDGAVTVAATNYVGVVSAGLAAARRLRTQGHGTIVVLSSVAGERVRKANFVYGSSKAGADGFALGLGDSLAGSGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI8</accession>
    <name>A0A7K0JXI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001094">
        <property type="protein sequence ID" value="MST34602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="16934" checksum="BB0A9A4254B429B1" modified="2021-04-07" version="1" fragment="single">MVPGQGGRPERTVARTQAPARREARHVVGRAAHLGPGAPVVAVVLVTGAGRGLGAAIAARLAADGARVGLLDRDEEQLARVAAEVPGGVPLGADILDEAEVEAALDRLEAAAGPDGSVTGVVNNAGVVRFGPLLELAQGDFRAVTDVNLVGTFTVARAAARRMAGAGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU0</accession>
    <name>A0A7K0JXU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000951">
        <property type="protein sequence ID" value="MST34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="11291" checksum="A6F21AFB31289612" modified="2021-04-07" version="1">MVQEVDVRTFAAAHADGALVIDVREPFEYAAGHVPGARLVPLSTVPRAVRDLPGDRAVYVICASGNRSLTAASWLSQMGFDARSVAGGTTGWAQAGFPVVHGTRENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW8</accession>
    <name>A0A7K0JXW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001229">
        <property type="protein sequence ID" value="MST34811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="227" mass="24514" checksum="5A268F6D3B4462B5" modified="2021-04-07" version="1">MTTERQPTGRTRVRRHRDRASYETAEIDAILDEGMICHVAACVDGVPWMIPTAYGRDGDVLYLHGAAGNHLLAAAGDGGDVVVTVSLLDGMVLARSTFNHSFNYRSVVVFGRAEAVTDPPEKAHALEVIVDHLLPGRSREARPPTDAELRQTRVVRLALDEASAKIRRGPASDQPDDVGLPIWAGVLPLRTVAGPAEPDVHNQPGVAAPAGFDQPRRWSLEEGDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX6</accession>
    <name>A0A7K0JXX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001221">
        <property type="protein sequence ID" value="MST34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="285" mass="30297" checksum="245D6C67C8078B32" modified="2021-04-07" version="1">MATAPPVGRVRFPTTRSGLTWQRRQITLSVGGRRRSSLLLTPAAGVRRRLPIVVELAGAYVTAAEEAARADYAAVTGPAVLVYPQDIGPGREDNWDAGACCGMAAAKHVDDVGFIAAVIRRVRSSVPHEGDAPVYLSGYSNGGKMALRMACTDPGLFRAVAVYGAVESLICHGDRPPPMSVLEMVGTDDPWTALDAASPPVTQRGFPEPTVAQEAGFYVRADHCAHHVAEGSAGPVTELRWVDCAGARQVGVAVWNDQNHGWPQKDGSEPSAQQVAWDFFRSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA2</accession>
    <name>A0A7K0JYA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001319">
        <property type="protein sequence ID" value="MST34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="10451" checksum="36DB6B021634EAB9" modified="2021-04-07" version="1" fragment="single">MTEDTGGVEADRATIDWHRPLHHTPAGTLSGGTAQSGGMQRREAISGARCGSEQLWMGEAVVAGGARSSDHHHGHSETGIYVVAGSPVFVFLEDGVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG0</accession>
    <name>A0A7K0JYG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">GHK86_19970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01001347">
        <property type="protein sequence ID" value="MST34993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="145" mass="15371" checksum="2F93D1CB8C2F932F" modified="2021-04-07" version="1">MNVVDANVLLYAVNADAEHHDASRGWLDGCLSGGESVGFAWVALLAFVRLATRPDLFPHPLTVDEAMDRVDAWLGAAPAVVVGPTSAHARVVRDLLRAVGAGANLVNDAHLAALAIEHRAGVVSYDNDFSRFPGVRWVRPGEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK3</accession>
    <name>A0A7K0JYK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03557 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001381">
        <property type="protein sequence ID" value="MST35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="32110" checksum="E022B97D2D797FC3" modified="2021-04-07" version="1" fragment="single">MAAFGYTMLCEQRDPRGLVEDVQAAERAGFDFSVISDHYFPWLDEMGHSPYAWSVLGAAAQATERIGLMTYVTCPIKRYHPAVVAQKAATMALLSESRFTLGVGAGENLNEHVTGGGWPPADTRHEMLAEAVEIITRLWEGGYVDYRGRHFDVDSARLWDLPDTPPPLGIAVSGASSCELAGRYADLMIAVEPDASLGRRFDEAGGRGKPRVGQVPVCYDPDRDTAVKRAHELFRWFGSGWKVNAELPGTAAFAGASQFVRPEDVAAAIPCGSDVDEFVDAVRAFTDAGFTHVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP1</accession>
    <name>A0A7K0JYP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">1,4-alpha-glucan branching protein GlgB</fullName>
            <ecNumber evidence="8">2.4.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glgB</name>
        <name evidence="8" type="ORF">GHK86_20015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001353">
        <property type="protein sequence ID" value="MST35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="282"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="647" mass="71555" checksum="8AFD4B3FA9F6F1C1" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR3</accession>
    <name>A0A7K0JYR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001424">
        <property type="protein sequence ID" value="MST35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="15170" checksum="E44AB63CB5C2F6A4" modified="2021-04-07" version="1" fragment="single">MSQALVLNATYEPLCVVSTRRALLLVLDGKAEMLSATDRVFRAARLRIAEPSVVRLSYYVKVPYQARVALNRRAVFARDGHRCQYCGASAENIDHVVPRSKGGLHAWDNVVAACRPCNTRKRDRLLEDSGMKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU7</accession>
    <name>A0A7K0JYU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001446">
        <property type="protein sequence ID" value="MST35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="291" mass="31287" checksum="D023EB7607A20780" modified="2021-04-07" version="1" fragment="single">MHPLPPVAIPPALADIAARVDERLAACLDADAARWRALDPTLGAPLASLRSLVLAGGKRLRPAFCYWAFVGMGGSAEDPVAVEAGAALELLHTFALIHDDVMDGSPLRRGVTAVHVEHGRRHTLAGWRGDAERFGHGVAILVGDLAFVYSDRFLATAPPVARRVYDEMRLEVNVGQYLDLLGTAERTGDPELARRICRYKSGKYTIERPLHLGAALAAPDRFDRVDAALSAFGLPLGEAFQLQDDLLGVFGDTAATGKPVGEDLREGKPTLLYALARSAATGADRRLLEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY4</accession>
    <name>A0A7K0JYY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001196">
        <property type="protein sequence ID" value="MST34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="19874" checksum="FC0710449499CA64" modified="2021-04-07" version="1">PGPRAVAVADADAAHAAAAGIGYPLVLKTDEAGIAHKSDVGGVVVGIRDGAALERAYRDLRDRLGPRAVVMAMAGPGVELMLGMVHDPLLGPLLVLGAGGVEVELHADRRVALPPLDRTTARGLVDGLAARPLLDGFRGRPGADLDAVCDAVVAFASLTDELGPALDALEVNPLRCDPRGVLALDVLVAARRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ59</accession>
    <name>A0A7K0JZ59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Biotin transporter BioY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001540">
        <property type="protein sequence ID" value="MST35236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="6501" checksum="7B1F38EE69B70D83" modified="2021-04-07" version="1" fragment="single">MTAAVSLPRRPHVLSDLVAGSAVRDVLLVTAGAALVGVLAQVSFHVPGTPVPVTGQTFGVLLAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ84</accession>
    <name>A0A7K0JZ84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1348 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001549">
        <property type="protein sequence ID" value="MST35247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="17892" checksum="D9CFA23456456B68" modified="2021-04-07" version="1">MPDQRPPLPPFNAETALQKVRAAEAAWNTRDPVRVAGAYTVDSVWRNRDTFLQGREEIIAFLTEKWERELDYALRKDLWAYEGNRIAVRFQYESRDRDGRWWRSYGNELWEFDEHGLMCRREASINDVPIQATERRIVGARPEGDEAAPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ99</accession>
    <name>A0A7K0JZ99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001285">
        <property type="protein sequence ID" value="MST34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="357" mass="38575" checksum="E8143D3B1ED51040" modified="2021-04-07" version="1" fragment="single">MISPAPPRTGRRHNLMDGSTPLVSDRVIFRPPTAPTFVVSTARSGSTLLRWLLDSHPDIACPGETDLAGLVADYVGAAGRLGNPGGMQATLAGAREVASGLMERYLAGSGKRRWVDKSITSALHLDVLRAVWPDARFVFLYRHCMDVVASGLEAQPWGLSDYGFADFAKASPTDHVAALAAYWLDRTTRMVQGEAALRGRSIRIRYEDLVEDPDRALHPVWDLLGVSPAPDVARNAFVESHDAAGPADYKVWQTSSVRGDSVGRGARIPADRVTGRLREAVNELLGDLGYPLVDDRWGCPGPRPAGPASDAGLVDLRIVDGHRVLWRGVLREHDGSLHDPRTVPPAGAVVIVEREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI7</accession>
    <name>A0A7K0JZI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_21965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001694">
        <property type="protein sequence ID" value="MST35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="TSPc" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21898" checksum="FDE307994D0BC845" modified="2021-04-07" version="1">PDMMSAGWAELNRDLRTETRRDALVADFRHNRGGHTSALVLERLAGKVTAWDNPRGFEAGTYPMDAPRGPMVALTDQYAGSDGDIVSAGFRQRGLGPLVGTRTWGGVIGIDGRYSLADGTVVTQPRYAFWFVGGLGWSVENYGVDPDVEVPIAPQDWAAGRDTQLEKGVELLLAALEEHPPARPPSRTDRPSRVPPVLGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZQ9</accession>
    <name>A0A7K0JZQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001685">
        <property type="protein sequence ID" value="MST35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="286" mass="28416" checksum="C281E8CF3683BD74" modified="2021-04-07" version="1" fragment="single">MVLPLALAGTITAVARQDLRRLARVWLVGVPVGVGAGGILSALVAVSVGAVDELCGLLHPAAAIVAVSGAAGADLAGTPEGVQALVGLLLLAAGVCLWLELVLRAASVYLALFFMPLVLATLLWPTVSGAAKRFLELLAALVLAKLVIVGALCVGAGALGAAHGGIDAAISGAAVLLLAAFAPFAVLRLVPFVEVGAVAHLEGLSRQPVRAAEAVPQRVAAHASRAGALLGQLHRPPSGGLEASPSPRLPLPEHPTDWTLPPDPHGVEGTGRPPGGGDPPAPGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K019</accession>
    <name>A0A7K0K019_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001466">
        <property type="protein sequence ID" value="MST35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="22185" checksum="FFA38E6780B5EED3" modified="2021-04-07" version="1">MESDHSGQIVAAARLLFAAGVMSHSGHANLSARLDGDRMLITSSGAVRDLTAEQLATVGFDGTVLDGELAPDNAEIVAMHTAVYRAQPDVGAVIHTHSPSATAFALAQRPLPCRTEPLLRFGQAEEIPVAPWGPRGSDASVRGIADALAAQPTTSAVLLANHGLLAFGSGPVATARLVVAIEESAEAELAAAALGGAVDFPPGALEAVRASMARSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMI5</accession>
    <name>A0A7K0JMI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000004">
        <property type="protein sequence ID" value="MST31135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="5204" checksum="45B2D754D66BAC60" modified="2021-04-07" version="1" fragment="single">MRVFVTGASGWIGSAVVQDLLGAGHEVVGLARSDASARRLQAAGALPRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX5</accession>
    <name>A0A7K0JMX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">GHK86_01035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000036">
        <property type="protein sequence ID" value="MST31316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="138"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST31316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="435" mass="45181" checksum="D141286BFBDE243E" modified="2021-04-07" version="1">MSAIDQLIARQILDSRGNPTVEVEAVLDSGARGRAAVPSGASTGSFEAVELRDGGEAYGGKGVRTAVEHVEGPIAEAVEGLEAVDQRGVDLALIDLDGTADKGRLGANAILGVSLAVARAAAEECGLPLFRYVGGSGAHLLPVPMMNVLNGGAHADNNVDFQEFMIVPVGAASFGEALRWGAETYHALKAELRERGLSTAIGDEGGFAPDLPSNEEAVATLVRAIERAGRTPGDDIAIALDVAASELYRDGRYELAGEGRSLPAGELAALLAGLVERYPIVSVEDGMAEEDWDGWGLQQEALGERVQLVGDDVFVTNPARLQRGIDAGVANAVLVKVNQIGTLTETLETVGLATRNRYAAVMSHRSGETEDTTIADLAVATGCGQIKTGAPARSDRVAKYNQLLRIEELLGDTARYAGRGAFAPFGGGRRGAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN43</accession>
    <name>A0A7K0JN43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulokinase</fullName>
            <ecNumber evidence="2">2.7.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.16" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000028">
        <property type="protein sequence ID" value="MST31271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="291"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="358" mass="37136" checksum="C9EB4619CB1B450B" modified="2021-04-07" version="1" fragment="single">MMAGAERYVVGVDFGTLSGRALVVRVSDGAEMGSAVHELAHGVMESALPSGRPLAPDWALQHPADYLEVLGTAVPEAVAAAGVDPGAVIGIATDFTACTVLPVTAAGTPLCLLEGLADEPHAYVKLWKHHAAQAQADRITTTAAERGERWLARYGGRISSEWQLAKALQLLEEAPELYRIADRFIEAADWIVWQLCGVETRNACTAGYKGLLQDGTYPSHDYLAALHPDLADFYATKVDHPLSPLGSRAGSLTAAAAALTGLPAGIAVAAGNVDAHVTPPAAKATGPGQMVAVMGTSTCHVMSGAHPADVDGMCGCVQGGIIEGLWGFEAGQSGVGDIFAWWAERITGGGADAHERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN90</accession>
    <name>A0A7K0JN90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein translocase subunit SecF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secF</name>
        <name evidence="10" type="ORF">GHK86_01595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000065">
        <property type="protein sequence ID" value="MST31426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="353" mass="37390" checksum="DDFFDA99A33047AB" modified="2021-04-07" version="1" fragment="single">MAGRGGAFGRLYRGETSFDFAGRWRRWFAISGTIIIIGLLSLGIRGMNFSIDFKGGTVWQVPTTASVQQVRAAVEKVDPKLSQATIQVLTSRATHQRTVQVAGAASTTSSSATVKDVAKALATVAHVNPNAVNINAIGPSWGSSITNKAIKAVIIFLIVVSAYIWFRFEGKMAVAALTALVHDILITVGIYSLSGLAVSPDTVIAFLTILGYSLYDTIVVFDKVQENTRGVASSNRLTYTETVNLSMNQVLARSLNTSFVAIIPILSILVIGSGILGAAALNDFGLALFIGLTTGAYSSIFIASPLLALLKEREPRYAEIRHRIGGGAPRRLSPRAAAAGGEAIAVGSRRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNC9</accession>
    <name>A0A7K0JNC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000056">
        <property type="protein sequence ID" value="MST31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="4"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="502" mass="54426" checksum="1124602FC8F4F43C" modified="2021-04-07" version="1">VYSNGDRKVTIHLKAVHWSDGKPLTARDVTFWINLLRANKNNWGEYAPGYFPDDVTSVATSGQSTVVLDLASQVNPTWFTFNELSQIVPIPQHAWDKTSPTGPIGNYDETQAGAHAVYKFLDAQSRNLNTYATNPLWQVVDGPWRLSRFSPDGYAAFVPNKSYFGHKPMLARFVEVPYTSESAEYDALRSGSLTYGYVPISDLGQKALLESQGFQVTPWYLWSMNIIPMNFNNPSQGALYRQTYIRQAMQRLINERQLESAVLNGYGITDNGPIPNGPSTQYVDATVKAGPLAYSLAAAKSLLESHGWHPGAGGVAVCARPGTGSQQCGAGIKAGTPLRFTMVYAAGVASISQEAQALKSSFSQAGIDLALTQQPASQVYAAAVPCTSKQSDCSWGMAYWGNGWEFSPDNYPTGEVAFATGAVGNFGSYSNPRMDALIKATTTQPGQGPLNAWQDYTAEQLPMLFMPVSPVQVSAISTKLHGAVPQPADGLTLTPEFWSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JND9</accession>
    <name>A0A7K0JND9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000058">
        <property type="protein sequence ID" value="MST31397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="29438" checksum="60BE00F7B7C63F3C" modified="2021-04-07" version="1" fragment="single">MRPTVAAEAFGFDSGYWARLEALVRPEFRVERYHPGHDDAVLRRPGCRVVGCEALAYGNGRWCTRHAEEWTASHLDAGAFAAAATPAGGRYRSGSSPCLVASCPNRAGRSGLCRGHLGRWQREGRPDKEIFVGATAAVAVIGNCAVAGCGRPSHTSFGFCHGHHKLWVDAGRPDGDGFSASVRALAPVEPTYDLSGLTGGYRLELQYVLQVRKDEGKARLTPGAILPTVEMLRAHPGPSVLQRRLLVWENLLDPRWSRPARQGGRAVSSHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH6</accession>
    <name>A0A7K0JNH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ORF">GHK86_01465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000060">
        <property type="protein sequence ID" value="MST31401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="17199" checksum="BEB7F08E4EEB808D" modified="2021-04-07" version="1">MRCPQCSAMDDKVVDSRAAEDGGAIRRRRECLHCGRRFTTYERLEEVPFVVVKRSGEREPFDRRKVVEGIGAAAKNRPAVAAARDGLAAEIEEELRLEGSEVTSERVGRAVLARLRDLDEVAYLRFASVYKGFTGAGDFEREVGLLIKRSAPKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ0</accession>
    <name>A0A7K0JNJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">rplK</name>
        <name evidence="12" type="ORF">GHK86_02030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000086">
        <property type="protein sequence ID" value="MST31508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029628972" description="50S ribosomal protein L11" evidence="9">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="10">
        <location>
            <begin position="72"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14904" checksum="5B00AB6787C49C08" modified="2021-04-07" version="1">MAKRRVVAIVKIQLPAGKATPAPPVGTALGPHGVQTMDFVKQYNAQTEDRVGQVIPVEITIFEDRTFSFVLKTPPTPVLLRQAAGIDKGAATTGRETVATVTDEQIAEIAQIKMPDLNANDLEAAKAQVAGTARSMGIKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ4</accession>
    <name>A0A7K0JNJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsA</name>
        <name evidence="3" type="ORF">GHK86_02190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000093">
        <property type="protein sequence ID" value="MST31540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="224"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="309"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="478" mass="51932" checksum="B4FA6CC622423AB9" modified="2021-04-07" version="1">MTDITASPSPAGMGTFDETGTYVPRQVVVDDLGGQSLEDAISGTIVEFDDGDIVEGTVVKVDKDEVLLDIGFKSEGVIPSRELSIRHDVDPSEVVTLGDHIEALVLQKEDKEGRLILSKKRAQYERAWGTIEAIKERDGVVSGPVIEVVKGGLILDIGLRGFLPASLVELRRVRDLLPYVGKNLDAKIIELDKNRNNVVLSRRAYLEETQKEQRDEFLANLKPGEVRRGVVSSVVNFGAFVDLGGMDGLIHVSELSWKHVDHPSSVVAVGDEVEVRVLDVDLSRERISLSLKATQQDPWQEFASAHRVGELVYGRVTKLVPFGAFVQVGEGIEGLVHISEMAVHHVDLPEQVVTPGEELWVKIIDIDLQRRRISLSIKQAAEGGEVAAEYREAFGEHAYDEQGNYIGPSFADFEPESEAQAAWAEYLEETAGGGSGSGAAAEQSDGPVWTSEAPADEAPTEEAPAEEAPAEEAPAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ3</accession>
    <name>A0A7K0JNQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching protein GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ORF">GHK86_02205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000094">
        <property type="protein sequence ID" value="MST31543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="135"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="709" mass="79868" checksum="793910164C9CE307" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV3</accession>
    <name>A0A7K0JNV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="25685" checksum="78A36BE2FC839B86" modified="2021-04-07" version="1">MSGVRMLVVGAHSADFVWRAAGALANNHAAGGSSVVVALSFGERGESGELWKVPGQTEARVKDARRAEAQQAADIVGAELVCLDLGDYPLVVDDTGLEGLLRVVRDLRPEVVITHPAADPFNPDHPVAYQATCRARLLSSGAGVASAFETVPPSQLFVFEPHQPELSGFVPTTFVDITDSFERKRQAMEAMAAQKYLQQYYAERAGHRGNHARKVTGNSEIRYAEAFQRVTPQVVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY1</accession>
    <name>A0A7K0JNY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000112">
        <property type="protein sequence ID" value="MST31668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="37211" checksum="AA161DEA4C291135" modified="2021-04-07" version="1" fragment="single">MGRRILVTGLGSYWGGRVARALETRPDVDVIVGMDTAAPRVALERTEFVRCDETYSILARLVRATQVDTVVHAALIVDSTGSGARRIHDNNVIGTMNLLAAASASDSAVRHLVVKSSALVYGADQRDPTWFAEDTPRSAPARTSIERSLIEIEGHLQGFAEEAGGRRVAILRFANVLGEGIVTPLTRALDLPAVPVVAGFDPLLQFVAETDVVAAMAWAVGRELEGTFNVAGDGRLPWSEVIALAGKHPWPLPPLGAPLWGELLGRLRVVDLPPEVIALLRYGRGVDNRRSKEAGFRYHCSTLGAVQAHVERQRLRHAVGAEPGYRYEAEVEAFFRHSPAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP33</accession>
    <name>A0A7K0JP33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2786 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000120">
        <property type="protein sequence ID" value="MST31705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="1">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="18165" checksum="0159EAF8EDC679D3" modified="2021-04-07" version="1" fragment="single">AAGVAGAPDDPVLAKVRALLAKAESTQFAAEAEALAAKAQELMARHAIEEAVARSTASWEERPIIRRLAVDDPYAEAKSTLLGVVARANAARCVWYEPYALMAVVGYARDLDAIEALFTSLLVQASRAMLDNGSVTDGAGRSRTRSFRQSFLLAYAVRIGQRLEEAASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP74</accession>
    <name>A0A7K0JP74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Winged helix DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_03135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000125">
        <property type="protein sequence ID" value="MST31723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="214" mass="23183" checksum="1102F77AF104BDB6" modified="2021-04-07" version="1">MEEYLEAIHELEEEGTPVIQARLAERLDHSAPAVSEMVRRLREAGFLEITGRTLALTDPGRALAESVVRKHRLAERLLTDVIGLPWASAHVEACRWEHVISDDVAARLDVLLGHPTTCPHGNPIPGTGPDRRHLTPLAAARAGERVRLERVTEQIEIDGEALAYLADHGWVPGAEAMVSSRAPDGTLTLSIDPDGRGMALSPALAQQLYVGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE6</accession>
    <name>A0A7K0JPE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="24110" checksum="2577A70BE7DF1238" modified="2021-04-07" version="1">MLEEHNVNDDLTTTVVVTDAGGGPDGSGGSSTPEREVVGVTVGAGGDPLIVILPLFCVGSLALGILLTGWLAPLAALTGIVPIMSVATGLTLLLGTVWALLLGLTIVAGISGIFAGFWLSLSALLLGLDHGWYAMPATATSSVEELFFICWAILIFMLLLPVLKLPLAYPLIVALVVAALVLSAIAASGTDPVEVFRAAGIVVLAFAAIGLYAFVSVGLAALDFNVSLPLGPIPGSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL2</accession>
    <name>A0A7K0JPL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000157">
        <property type="protein sequence ID" value="MST31863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="26560" checksum="45326F0817B1D8C1" modified="2021-04-07" version="1">MAVLDRFRLDGKVAIVTGASSGLGVAFATALAEAGADVSLGARRLDRLEETRQVVESLGRRAITVATDVADPEQCGRLVEETLDRLGRVDVLVNNAGVGTAVPASRETPAEFRQVLDVNLMGSYWMAQACARVMRPGSSIVNVGSVLGSTTAGLPQAAYCASKAAIIGLTRDLAQQWTGRKGIRVNAVAPGFFPTEMTMAYPHGYLEAVVEQRVPAGRPGDLEECAAAVLFLASEAASYVTGILLPVDGGLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW7</accession>
    <name>A0A7K0JPW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_04575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="WJHE01000193">
        <property type="protein sequence ID" value="MST32000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="442" mass="48712" checksum="0D3DA44DBDACD507" modified="2021-04-07" version="1">ELAATLAPPTHRLADRPVPPDTAYQLVHDELLLDGNARLNLATFVTTWMEPQAARLMADCAEKNMIDKDEYPQTAALEQRCVSILAHLWHAPVADDAVGCSTTGSSEAGMLGGMALKRRWMQRNPDAWRQGRRPNLVMGANVQVCWEKFCNYWEVEPRLVPMEGDRYHLDAASAVERCDEDTIGVVAVLGSTFDGSYEPVAAIAGALDDLQARTGIDVPIHVDGASGAMIAPFLDPDLAWDFRLPRVASINTSGHKYGLVYPGVGWIVWRSHEALPEELVFTVNYLGGNMPTFSLNFSRPGAEVVAQYYLFLRLGFEGYVGVQRASREIAQDLAGRIEGLGPFRLLSRGDELPVFAFTTTPEVTAYNVFDVSRRLRERGWLVPAYTFPADREDLSVLRVVIRNGFTEDLAGLLVADLQRLLPELGAQPGPLQAPAEATAFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX6</accession>
    <name>A0A7K0JPX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="517"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="699" mass="75203" checksum="71226B2F90605A7F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ3</accession>
    <name>A0A7K0JPZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="27691" checksum="2F19B9A4691B8E65" modified="2021-04-07" version="1">MPSSSQFASDFVNDYQSHYGAVAVNQMPVWTVPADQAPVPVHVKAGCANFTTDTGTAIPIPPAATTTGTGDSPLVIDQPSTSSEWELWQASPTGNGWSACWGGRLDTSTSDGVFPNGYGLSGSGISYLATTITEADIASGSIDHAIALDLPACNAPQVFPADRTDCSNDPGQPPEGTWWRFPSNLPMPSGLTPFGKMVFKAIQTYGLVQTDQAGAVAIQAENTADWAAQGHSGVDPITASWQGQQEWQVVADLPWSHIEAISAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ7</accession>
    <name>A0A7K0JPZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="36139" checksum="0F1807E0130792C8" modified="2021-04-07" version="1">MRAVVLTGFGGPDKLEYRDDLPDPQAGPGEVRVRVGATGINNTDIWTREGAYGREADSAQSGWQAGGFAFPRIQGADVVGRIDAVGEGVPVERVGERVIIDPALYVGAEAGLATTPYLGSERDGGFAELVTVPASNAVRLETELSDAEAATFPTAYATALRMLRRAGLEAGECLLVTGAGGGVGSALVQLGVLRGATVVAVTTGAKRDWVLGLGAAAVVDRSEGDLLQQLLATGCPPPAVVADVVGGPLFPDLLDLLAPFGRYVVAGAIAGPLVQTDLRTVYLKQLQLIGSSMAAHEEFAALVDLIQAGSLKPLLARAYPLDQLRKAQADFRMKDFVGKLVVTVSAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ30</accession>
    <name>A0A7K0JQ30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TraM recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="3">
        <location>
            <begin position="505"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="666" mass="68332" checksum="89C8248614DE4B30" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ42</accession>
    <name>A0A7K0JQ42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000204">
        <property type="protein sequence ID" value="MST32072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029837386" evidence="1">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="17398" checksum="1C281748F40DA874" modified="2021-04-07" version="1" fragment="single">MNANSSHLSRLCSACLLTGATIAGAASAGASPAPSLAAHLALGPSVAGRATPVHLSVTDPTAVPLGRLLVSAHLPWGVAYVPGSITAHEDRAAVAVGAPRVVLAPGGQTELYWGDLPAPGHGALELSFDVRPGARTSTHWAGSSWSVFTAVRAVPAGGGGTTGAAEGAMAAVTRAGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD9</accession>
    <name>A0A7K0JQD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">GHK86_05435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000229">
        <property type="protein sequence ID" value="MST32168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="434" mass="46080" checksum="8AF1AA2A4A8D722A" modified="2021-04-07" version="1">MSDAWIIEPNGPLRGEVAVRGSKNAVTKHMVAAILGSEPSTIANVPEVGDVEITSSILRAIGAGVEREGDRVTITPPEAPGSAVPLSFSGLNRIPVLLLGPLLHLTGEAWVPRVGGDRIGSRPVDFHVQMLRTLGAEVEVTDDGISARCSRLRGAIIELPYPSVGATESALLSASLADGKTVIRNAATEPEVLELALLLQRMGARIELAPDRRIVIEGVPRLRGSTTRLEGDRNEAFSYLVAGLLTGGQVTVRGCGQDRLVTAITTLLRMGAEVELDDRGMTASAPNGLRAAAVQTDVHPGFMTDWQTPLMVLFTQAEGMSVLHETVYEDRFVYVPALQAMGGEIELFSTCLGGPACRFHDSRYLHSAVVRGVSKLHGAEVDIPDVRAGFSSVIAAAAATGTSVLHGVHHLERGYHRPADQLRSLGLELRTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK0</accession>
    <name>A0A7K0JQK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000232">
        <property type="protein sequence ID" value="MST32177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="18166" checksum="AA33318F0A01673F" modified="2021-04-07" version="1">RFDWVDGHRLGVQGGSYGGYLTSWIVGHSRRFRAAVSERSVNNLLTAEYNSDISGFFKEAVGWTHLERPDLYLRQSPSTYIADMHTPMLMVHSEDDLRCPISQAEELFVGLRLLGRDPELVRFPGECHELSRSGSPRHRVQRAEIILEWFRRHLATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM9</accession>
    <name>A0A7K0JQM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000168">
        <property type="protein sequence ID" value="MST31894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="152"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="339" mass="36499" checksum="45C7C7E73B1EC5DE" modified="2021-04-07" version="1">GTPIENGLGDLWAILDFVNPGLVGGRTAFIEQLSRVTADDRSRPVGVEEGALQALNGLLVFRRTKGEPEIAAELPDKVDKLDHCGMTPEQVGLYQAVVNRLLDGGLDTDANQRKGQVLAAITALKQICDHPAAYLGEEDDQPLTGRSGKLSRLEDILGDVFAAGERALVFTHFASWGEKLARHLSGRMGYPIHCYHGGLARGARDQMIEEFQNGKGPGALVLSIKAGGSGLNLTAANHVVLYDRWWNPAVEDQARDRAWRLGQKSTVVAHRLVCPGTVDERVEEIVAGKRRIAGLVLPARSSLGDLDAEQLRVALGLNPDELIEDEPGGGDDEDTQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP3</accession>
    <name>A0A7K0JQP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_05880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000257">
        <property type="protein sequence ID" value="MST32252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="145" mass="15161" checksum="BEA25ED8A92AE557" modified="2021-04-07" version="1">MAPAGQRHVRGHRTVPHTADVILEAWGPELASCCEEAVAALVDTYVAGGDVTTVAERRVRVECPSAEAALLAVLDEVIFALDVAEGVPVAARIGEAGTGGLSVVVQLADRERLEPTGAVPKAVSRSGLQVDVRRGRVGCRFLVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP5</accession>
    <name>A0A7K0JQP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000169">
        <property type="protein sequence ID" value="MST31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="17337" checksum="B55DD0B73195D471" modified="2021-04-07" version="1">MVTGKMTTLGAGNFTVGTDIPAGLYNVTAGAGQSGNFIVNGGDSYNEVLGSADGLGVPEVRARLRKGDKIELSGLSSVTFTPVATPYVTTVKVVDLYAGTWIVGQDIAPGRYVATPGAGQSGNFIVNAEGIDEILGSADGIGVPNVTVTLHKGDVIQIAGLARVVMTPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS5</accession>
    <name>A0A7K0JQS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000255">
        <property type="protein sequence ID" value="MST32247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="140"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="643" mass="69480" checksum="DEC4C094276B4735" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS9</accession>
    <name>A0A7K0JQS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000267">
        <property type="protein sequence ID" value="MST32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="12878" checksum="E79ECD48C8324BB0" modified="2021-04-07" version="1">MFDLSPEKLLLLGMIALVFLGPERLPRAARKAGEVLAQVRQMSGGLQQEMRSALAEPRQALEEARQELGLPTIPRVPSVRRAVVDSLTGAVETPSWVGTSSAGGGDAGDPGGLPPTPDDPALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV1</accession>
    <name>A0A7K0JQV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000268">
        <property type="protein sequence ID" value="MST32312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="7926" checksum="860D56AD569F0019" modified="2021-04-07" version="1">MRTNRRSGGADDDDPAVDRGRARSHHSVPRPIEPLLPREFTAPVDYRWPDYVPTPDGREWWIPDNPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV2</accession>
    <name>A0A7K0JQV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000271">
        <property type="protein sequence ID" value="MST32330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="27864" checksum="0FC8656D909A5461" modified="2021-04-07" version="1" fragment="single">MTDLDGYLGSDGVDVDVVVVSRPANAERYRPVIDRRLAGRPVVYDAEALFFRRLERQAEVADPEARAGLLEQAAAMRALERDLASWADHMVTISEDEAGTIRPFTRAPVHVVGPRRRGAHPTASAYEARSGACLVAGWAAGPGSPNADGLRWFARDVLPRIRSQLPAFRLLVTGDDPPPDVTWAAGPAVEFVGGLPDLGELYDRVRVAISPTRFGAGVKLKTVEAVQHGVPVVCTVEAAAGLGADLAAAVWVAGDAPAFADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY5</accession>
    <name>A0A7K0JQY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-carotene hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_06385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sterol desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000276">
        <property type="protein sequence ID" value="MST32348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045019">
        <property type="entry name" value="BETA-OHASE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31899">
        <property type="entry name" value="PTHR31899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="18370" checksum="C90C56A1BB5F5356" modified="2021-04-07" version="1">MVGVLGPVLAGAGAFVVMEPLTYAAHRWVMHGAGWVLHRSHHRRRRIDSWRDRFEANDWFPVMFATGTVAAMAVGAGVESASVLVPVGVGVTLYGAAYAFVHDVYIHARVGRLPVLAPLERLRDAHAIHHLFGGEPYGMLCPIVPRELRERAAARTTDPLVRRPAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC6</accession>
    <name>A0A7K0JRC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000308">
        <property type="protein sequence ID" value="MST32482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046094">
        <property type="entry name" value="DUF6112"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19607">
        <property type="entry name" value="DUF6112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="10914" checksum="347DC12A397F31D3" modified="2021-04-07" version="1">MLAATALLAAAGSSGISPTVVPNLAPKSSGLPGTQVLVGLANGLGFWALIAAVVGVVVGAVVWAFGHYSQNYQQAYNGRKGVMVAGLAALLIGGASQIVRFFVQQGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF9</accession>
    <name>A0A7K0JRF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twin-arginine translocation signal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000324">
        <property type="protein sequence ID" value="MST32536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="113"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="540" mass="57847" checksum="587CEEC2CC539E3B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ8</accession>
    <name>A0A7K0JRQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="31"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="28415" checksum="FC81F2CCA7A4EB56" modified="2021-04-07" version="1">MELFVLPLGECCCDYEVIAPGVRDGHRVHIPVNAFLIRLPDDRLVLVDTGMSRLHVRDPELTWRGTPNGEALLPAMRKEDSLLFRLAQLEVAPQDIDFVINTHLHFDHAGNNDLLGRATFFVQRDQYEQAKGNPSFPNQYWNLPSLSYELLDGATELWGGIEVRATPGHCEGHQSVVVRLPETGTVILCGDAVYCQDNFDRDAWDGQADPELARQSAHELRHLAEHDGALMVYGHDPEQFHTLRKAPEASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX4</accession>
    <name>A0A7K0JRX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptidase I</fullName>
            <ecNumber evidence="6">3.4.21.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000364">
        <property type="protein sequence ID" value="MST32696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="5">
        <location>
            <begin position="30"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="19872" checksum="BB5F01A7C03A86CD" modified="2021-04-07" version="1">MRKILIRVGLGLLAAVFALCAYVSVLTNHVYVTTPSMYPTIPPGSLVFIQPQKTYRVGDVIEFHGNGLVFMHRIIRINRLGDITTKGDNPENVPDVFARPVTKADVIGKEVLAIPYVGFPELILHRPGYGLAWLRAELGFTGRLILIGAVALLTCLYSWVAGRAARVALRRRADLSPTPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS11</accession>
    <name>A0A7K0JS11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000370">
        <property type="protein sequence ID" value="MST32725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="1">
        <location>
            <begin position="101"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="396" mass="43347" checksum="D8A40DDF8A511C05" modified="2021-04-07" version="1">MVTGWVGGQPLRAQLTVDTDRTATQLADRLGTPVLELADERSVAERLDDGKVRRWRALELEPLGADRRLTDAVISQLIAAGARPAGEALAYDVALGVTVRPAPAGDVVAARLRQLATELGEQDLLFRQDAPEAVHDFRVTVRRLRSLLRTFRPLLEPSPAAQLRAELGWLGNLLGEARDAEVLEERFAAALAAVPAEEQLGPVRADLVGGVRSTRLAASARLVDELDGDRYRDLVDRLHTFAGDPPYRRGYSGADSRAVTRAAGRELRRVRNRVAAAEGAADADRDTAYHEARKVAKRVRYAAETLRPLGRKRARRLEQAFKAVQDTLGARNDAVVARRILVAEGAREGIRTGHNGFTYGVLAERERHAVAEADAAFAPAWREALTAGRSWSKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS23</accession>
    <name>A0A7K0JS23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000375">
        <property type="protein sequence ID" value="MST32741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="196"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="28806" checksum="6262BF74DE85606D" modified="2021-04-07" version="1">MAGLDVNTNLMAIQAANNLSTNQTAMQNALTDLSSGYQINSAADNPAGLVISQHLQSQINGFQQAQANTQNAVNVAQTMDGALNGIGSILQTVRTLAVQSANSSASDSTATSAAQAEITQALSTIDNIAQTTVFGSNNLLWTANGAASGVLTFNFQVGYGNTGGQVSFTIGAISSAALGISSISVTTLNGATTAIGLVDQAISTVSTERGTIGAYQNMFQDIAANNTVMQQNLTASNASIQDTNMATMMVKFTQDQILVQAGVSMLSQANSIPQDVLKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ0</accession>
    <name>A0A7K0JSJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000421">
        <property type="protein sequence ID" value="MST32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="26101" checksum="9D1DD4680337B1BE" modified="2021-04-07" version="1">MPEDTPPRVLVVAAHPDDIDFGSGATVAFLVATGWQVSYCLVTDGDAGGFDASVARDRIPVIRRAEQTEAARVLGVEDLHWLRYPDGRVAVDLALRRDLSRVIRTVRPDRVICQNPQRNWASVYGSHPDHMAAGEATLCAVYPDARNPFAYPELAAEGLEAHAVPEVWVVGGPDPDVVLDLTDYFDLKVEALRAHVSQETDRDGRLVPMLREWMGGTAAAGGLAEGRYAEAYRRIDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK8</accession>
    <name>A0A7K0JSK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000427">
        <property type="protein sequence ID" value="MST32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="7426" checksum="93322736548E264C" modified="2021-04-07" version="1">MIDIRAADHAMGLELQLEELTEQRTRAHVQGRHDDVAVLDDEIAALQLELARTAEAALGVVDPPAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM9</accession>
    <name>A0A7K0JSM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000435">
        <property type="protein sequence ID" value="MST32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="22925" checksum="531E3336AA85FAE0" modified="2021-04-07" version="1">MRIGIIGAGNIGGNLTRRWTALGHEVRVANSRGPETLQDLAAETGATAVPVTEAAEGAELVVVTIPEKAIPSLPKGVLDGRAPGAPVVDTGNYYPRQRDGRIAEIEDGMPESAWVAKQLGHPVVKAFNGIYADHLLGRGLPAGTPARIALPVAGDDEEAKAKVMALIDELGFDPVDAGGIDESWRQQPGTPVYGADLDADGVRKALAEASPERTAEWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST7</accession>
    <name>A0A7K0JST7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000450">
        <property type="protein sequence ID" value="MST33000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="9797" checksum="0B74B301D56B2C54" modified="2021-04-07" version="1">MDLDELQAVIAATYGERDAARGIPATVAWLAEEVGELARATRKGTRAEQLHELSDVVAWTASLANQLGLSLSEALARYAEGCPTCHRVPCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW7</accession>
    <name>A0A7K0JSW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine/betaine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000357">
        <property type="protein sequence ID" value="MST32674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029571208" evidence="3">
        <location>
            <begin position="45"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="4">
        <location>
            <begin position="73"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="364" mass="39355" checksum="7D8410558101C5EE" modified="2021-04-07" version="1">MTNQRKTGGTRMTSIRTSRRRRRTALGALGVAAAMLISACNASTSTGGASGNSGSSGGSSGSGQAASSGNKPTITLVTNSWEGSLANNVVAQYVIEHDLHYPVKLLDLSEIPAWPATAKGQVSAVLEEWGHAQQYNTYVKGSHQVIDAGQEGPLGNIGWYVPTYLMKAHPELATWKGVQKDWKMFVTPQSAPQGQFLDGSPSYVTNDAALVKNLHINMKVIYAGSEAAQLTEIETAYKQKKPLIFYWYTPQYQNAIYKFSQVQLPPWTTTCAKLAASKINCAYPPYDLYKIENAKLPSTAPAVAAFIKRFHWTSDDQDQVAFDLAVKKMSNAAAGKAFVDSHASLVQSWLHGPDTKIVVPPPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX8</accession>
    <name>A0A7K0JSX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_09990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000467">
        <property type="protein sequence ID" value="MST33048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="120"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="224"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="390" mass="43546" checksum="68B77FD7BA28AB49" modified="2021-04-07" version="1">MDLSYSPAQAELKARAAELAKRIMPYEQQCDEHEGLPADVLAELRLHTLDLRLNAVNMPAEWGGQGLSVLDQVLAQEELGQLTNALWDVVWRPANALRACDELQRERYLLPAIRGERRDCYAVTEEGAGSDFTGIQTTATADGDGFRISGEKWFVTVGDVADFLIVMAMVGPEREPTLFLVDRDTPGVSVKRTPRYMHAFVYKHPIFTFDDVRVGPEAVLGGIGAGAELTREWFVEERLMIGARACGAAERALREATEWAQTRQQFDRALIDNQMIQAMLADCAMDIATARALTYQVAAECDAGMPRKLVHAKAAMVKAVASEAAGRVVDRAVQIFGGRGYMREFPVERLYRDIRVDRIWEGTNEIQRLIVSNEIAKRGLDELLHPWPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ1</accession>
    <name>A0A7K0JSZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000350">
        <property type="protein sequence ID" value="MST32639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="69" mass="7396" checksum="A2ADD36F5B651E91" modified="2021-04-07" version="1" fragment="single">MTTGGTHPPEHLDFPSLFDDAVTGMAIVGLDGRFQAVNPALCRMLGYAAEDLVGLRTADITHPDDQPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT11</accession>
    <name>A0A7K0JT11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="36083" checksum="13DAB416619366D2" modified="2021-04-07" version="1">MPEVDFSHLFRLSDDTGLLEHARGAVPRREHGYCLDDVARGLVLLARELDPTGDQVRLAGTYLGFVAHAQVSDGSFRNRLSYDRRWTDDGGMGDWWGRAMWGLGSVVAGSGPAWQRTEGLDHFSLGCPRRSPWLRSMAYAALGAAQVLMSVPDHDGARELLVDFVSQVGRCRAGGPPWPEDRLSYANARIPDALLASGAALGDSDVVRRGTDLLDWLVEAQMVDGHLSPVPSGGSSVATVQRGFDQQPIEVTAVADAAARAFALTGQVHWRDTLAVAAGWFEGANDLGTPMHDPATGGGFDGLTVGGPNLNQGAESTIAWLLTRQLVAVGGHRRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT73</accession>
    <name>A0A7K0JT73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Relaxase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1100" mass="115966" checksum="32C46CD95CE2A7DC" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT85</accession>
    <name>A0A7K0JT85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000498">
        <property type="protein sequence ID" value="MST33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="34529" checksum="8C7FE4E370783C34" modified="2021-04-07" version="1">MGQRPDWTSDFPYRDWFSVVELGPGTHLISEPVHVNSYLIEGSERAVLLDTGLGLADIRKIAEGLSGKPLRVVNSHYHFDHSGGNRWFQEIAIHRSGATLLATPPPEDLAAAYMDYVHRLHADWVTYRELDDRYFRLLTGELYVRPLPEGFADEDFEILPSQATTLLDEGDVIDLGDRRLRVLHTPGHSPDSICLFEERSGMLFTGDTLSAGAIYAHAEDADVGSFARSTARLAGMAADVRRVFVCHFLRYESPASFLRAVGEGFERVLAGEAPLRPSIDFLGAPVVEACFEAFSIFLPAGWDPAVAGGGRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT97</accession>
    <name>A0A7K0JT97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000397">
        <property type="protein sequence ID" value="MST32814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="461" mass="49604" checksum="EE02E8D40729EC5A" modified="2021-04-07" version="1">MLAPKAEAVHSSACLVAPTVRRVLQPRVQRDVGFEFESNQLLTRQGDAEIGAPFASENEAINAFWKSGAKRLAKGEQIFSKPGISVEADDRGSDSDLEVVVEHLPETNTGRNQLDQRMTDLLTLVTHFSTQAAHTGDTAPATVSDGQGGFGVDNKKAMIQGPPWDRAKTAPQVTVGARLSNVGDLVRDLHGDPNESAPEAGQRAAGRMAMRGPSPNDSTKPKTATGEAKLLIDAHGLAQQAVNSYLAKNNGTPPGGSELEGFLTLVLAYAEAAPHKSAFLKSSTPLMAKTDLATMWGTLPGPVKTHYSQTSLLGKTELEKLLETLPGYKGRLDRPLFDVSSSAVVDENASFDKKGAARKTQWYHKLVMRDWVRKIVTKNVDQLTTANFPKLPGGREVEGYGVLGARMDADATQPATALPVFELRSASRLMTYGEAHQWALKMFDYIRSLNANPGGGHGRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG3</accession>
    <name>A0A7K0JTG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000525">
        <property type="protein sequence ID" value="MST33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="35784" checksum="88265A61C826587F" modified="2021-04-07" version="1">MRAVRVVGYHQDLRMDEVPKPEITGPHDVIVKIGGAGVCRTDIHILEGQWAAKAQVSLPYTIGHENAGWVDAVGSAVTNVAEGDTVILHPLITCGFCRACRSGDDVHCERSQFPGIDTAGGYAEYMKTSARSVVKIDGSLHPADVAALADAGLTAYHAVAKAARRLRPGDRCVVIGAGGLGHIGIQVLEALSPAELIVLDRNPEAVKLALSIGADHGIVADGSEAGQVMELTGGRGAEQVIDFVGEGGSSSQGLAMTRRAGDYHIVGYGEHIDVPAIDLISTEVNIIGNLVGSYNDLVELMALAAAQKVRLHTAKYPLDRFQDALDDLAAGNVRGRAILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ8</accession>
    <name>A0A7K0JTJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GHK86_11070</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="350"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MST33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="427" mass="43911" checksum="4ADE1E4C64B146D3" modified="2021-04-07" version="1">MHETRVRVGLLGCGNVGGALAELLLADGDRIAERTGMVLELRAVAVRSLSRPRAASIPPELLTTDAQAVAADPDLDVVVEVIGGIEPARTLILAALGSGKPVVTANKELLANCGTELFDAAAAAGRDLLFEAAVAGGIPLIRPLRESLAGERIHRVLGIVNGTTNYILSQMAAHGASYQEALAEAQSLGFAERDPTADVEGFDAAAKAAVIAHVAFGARVVAGDVDREGIGAIGADDIVSAHRLGFVIKPLAVIEEVDGAIGVRVHPAMVPAAHPLASVRDSFNAVFVEGEAVGELMFLGRGAGGAPTASAVLGDLLDAAHNLTVGGAGRTPALRAVPRRSIDDLVSAYYLTLEVADRPGVLHAVAGVLGDHSVSVRSMEQEGAAEGARLVFVTHPALERDMQACLQELHALDAVRRVGGLIRVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK1</accession>
    <name>A0A7K0JTK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000537">
        <property type="protein sequence ID" value="MST33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="295"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1297" mass="139014" checksum="C789E7FF8FFFF9C8" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW0</accession>
    <name>A0A7K0JTW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000577">
        <property type="protein sequence ID" value="MST33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="16672" checksum="7CFA1B1544746EA5" modified="2021-04-07" version="1">ARGEAAALPLRDGAVDAAVACLVFEHIEAVDAALAEVGRVLAPGGRFVFLLNHPLLQVPESGWIDDTILGEQYWRIGPYLREDSRVEEVAKDVWIPFIHRPLSRYVNGIVAAGLVLTGMEEPAPPPGFLALAAEYAEAATIPRLLVLRAEKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU68</accession>
    <name>A0A7K0JU68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000615">
        <property type="protein sequence ID" value="MST33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="19002" checksum="0065C00D94E703CB" modified="2021-04-07" version="1">MTLGPAGRRRAVAAAVLAVYALCSWLIALPLGLAPGSHLPTCACADVAQETWWLAVAAHAPFALHTGAVDVPRGVSLLDNASFPLLGALLAPVTRSVGPVASLVILLRLAFLTSAVAAYAVLRRLRGTDLGPAVGGALYAFSPYMTHQAGSHFFLAFGPLPPLLLGLVHRRMTSPTPRPWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU77</accession>
    <name>A0A7K0JU77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000613">
        <property type="protein sequence ID" value="MST33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="11717" checksum="AEB9BA0CC20D9D43" modified="2021-04-07" version="1">MTPTQLHSPTRIAVVAAASRWDLVVTGELDLASGQELVDVARVLASYRVPAAELDLEGVAFVDSAGLQAVDEALAVLAAAGTLTRVRRSGEAVERFRALFAGAVASTRATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU94</accession>
    <name>A0A7K0JU94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000623">
        <property type="protein sequence ID" value="MST33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="115"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="300" mass="30983" checksum="AC024FE5771D83F2" modified="2021-04-07" version="1">HVVLSWVPNCGSCRYCESGHPNLCATAMPALLAGTLVSGARRLSHEGEPLYHYSFLSTFAEEVVVDEAACVKIRDDVPLSVAALVGCAVTTGYGAVVNRARVEAGSTVVIFGAGGVGLSAVMAARLSGARHIVAVEPEATKRSLALDVGATHAVDPSTDDVSDIVSGLTGGDGADVAIEAAGRTELTALAFGLTRRAGTIVCVGVPAVGATVALPGPDLVRHEKVVTGSLYGSCRPHVDMPRILDLYAEGRLPLDRLVTRTYALDDINTGFTDMVAGRLARGVVDFALGASPLPREEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ7</accession>
    <name>A0A7K0JUJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000663">
        <property type="protein sequence ID" value="MST33611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="16630" checksum="D649714BA9531DD5" modified="2021-04-07" version="1" fragment="single">MVQGSASSPGSAPRPVSPETTATAERLGAPALALRIVDVVDEAPALRRITVEDPRLADVTWHPGQDLTLAIPGGGARSLKRRYTVRRLDHAAGTADLQVLLHGDGPGARWAAAVQPGDEVEAMGPRGKIWVRPDAAWHLFVGDEAYIPATFAMVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM0</accession>
    <name>A0A7K0JUM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000524">
        <property type="protein sequence ID" value="MST33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="18152" checksum="0952972D4C18774E" modified="2021-04-07" version="1">VAWPRARHATRRHRPDRRGRRGLAWKCSDLSAGDLRRRAVPTSNLSLLGLVRHLAEVERQWWTHAAGTPQPYRWCSADRPDADFDDVARADVDEAFAAWAEECERGRQVLAASDLDGTFGRTHYTFSVRWLAMHLVEEYARHNGHADLLREAIDGQVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ4</accession>
    <name>A0A7K0JUQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000688">
        <property type="protein sequence ID" value="MST33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="34940" checksum="4BF4A5BAC3A9D2FA" modified="2021-04-07" version="1">RGGCGTAAAGEGLAVLRRTLAGYARHPNVAGVVVLGLGCEVNQVDELVAEMGLPATVPLRAATIQGEGGTRGAVSWGVGQVRELLEDLPVTARQPVPAAELVLGLECGGSDAWSGVTANPVLGAASDLLVAAGGTAVLGETPEIHGAEHLLTARAVSPEVAHRLEQRMAWWEAYAGANGTTLDANPSPGNRAGGITTIEEKSLGAVAKGGRSPLTDVVGYAEAVRSRGLVFMDTPGYDPVSVTGMVAGGATVVCFTTGRGSVFGCKPVPSLKLATTSELYTRMPDDMDVDCGRVLDGVPVEELGAELFGRILAVASGERTRSEELGFGDEEFNPWQLGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV6</accession>
    <name>A0A7K0JUV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000567">
        <property type="protein sequence ID" value="MST33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013100">
        <property type="entry name" value="LEH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07858">
        <property type="entry name" value="LEH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="14899" checksum="FABC542BDEF2DE97" modified="2021-04-07" version="1">MQLVVEGLLASVEARDLDAVAAHLTVGATWANVPHAPTRGREAVCAMLAAVLGPAERVRWEVVNAAYAADRAHLERLDRFWIGGAELVAPCHGVFRVDPERGQVDEVRDYVDLGPWRAALAAAGVAGGTRHRAETDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX3</accession>
    <name>A0A7K0JUX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000713">
        <property type="protein sequence ID" value="MST33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="62" mass="6880" checksum="FCF8CAE84C8CE2C7" modified="2021-04-07" version="1" fragment="single">MELRTVRLGDPETEPVLADLADEYRRRYGGDGEMRTTAPEEFDPPAGRFLVLLDRGETVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ8</accession>
    <name>A0A7K0JUZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000720">
        <property type="protein sequence ID" value="MST33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="20023" checksum="D3C42729F748A2E6" modified="2021-04-07" version="1" fragment="single">MSAIRARRSAGSRSPADGVWLEAQRAPLASTVTLRIPGPGAPVVEAAADQPEPELQFWYRRTELQLGVGTDPFVERAVLDSLRARPAARDTTVVDACPGFVTTAMPAPGRLEHRLVLRVPGSTRLVFTPPRSSDRAGVPARSAWRALPLARGVRYRVFLARFSTDGAPQSHDELAWVVTGTPHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV85</accession>
    <name>A0A7K0JV85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000758">
        <property type="protein sequence ID" value="MST33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10025" checksum="34924631119196B6" modified="2021-04-07" version="1">LRDAGGRPRRVAMTGWEALTPAEARVAALAAAGHTNGSIAAQLYVTQKTVEGHLGRAFRKLAITSRSQLAELVPAPAREGEAWGPVGLLPAGPHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV90</accession>
    <name>A0A7K0JV90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000758">
        <property type="protein sequence ID" value="MST33876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05257">
        <property type="entry name" value="Arna_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045869">
        <property type="entry name" value="Arna-like_SDR_e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="330" mass="35285" checksum="EEFBE2819FEC1924" modified="2021-04-07" version="1">MQLTVAVTGAGGFIGSHLVETLVGAGHRVRALAQYNARSSAGWLDDLDSDVLAAVDVRFGDVRDPASVRTLLDGVDAACHLAALVTVPYSYELPGSYVQTNVVGTHNVLEVARELGTPRVVCASCGEVYGTARTVPMAEDHPLEARSPYAATKVAADKLAESYHLSFGLPVVVLRPFNTYGPRQSSRAVIPTIISQLAAGQERIAIGSLTPTRDFSYVADITRAFLAAVTGPDTMLGRVYNAGSGREISVEAVAHLIAGIMGSRVELAPEARRTRPAASEIHRLHADSSALQAVTSWRPEHTLEEGLAATVAWICRPGNLRYYDLHRYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD9</accession>
    <name>A0A7K0JVD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_14460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000770">
        <property type="protein sequence ID" value="MST33916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="23198" checksum="4F5A85EE981D5838" modified="2021-04-07" version="1">MDPVTVIAPGDTSALPPQAVRPVNPADYRPAFLNVGVIVWLASELMFFSGLFAAFYTLRAASVSWPTKGDHIDAVTVGMATIILVVSSFTMQMGVHRTTKADKTGFLGWLALTFALGCLFDGMQLSDYAGRNFPIWQDSWTSCFYVLTGIHAIHVAGGLLGMIIMGVRSKYSRKFGHHTLPAIEFLSYYWHFVDVVWIALYASIFLLRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF2</accession>
    <name>A0A7K0JVF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000784">
        <property type="protein sequence ID" value="MST33947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="17147" checksum="8180562AE5FC6414" modified="2021-04-07" version="1" fragment="single">MEGRPGEPSPTPTIYDVAARSGVSIATVSRVVNGHRAIRDETRERVLQAVRELRFVPNSAARGLSSGLMRVIGLVFARVPSEDDLLELEEETLLFTDSVIRGAELAAQRRGYSLLLHGTGGEKAAGALAALTSKTDGLILTDRVLPERRVSTIARNFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR8</accession>
    <name>A0A7K0JVR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000823">
        <property type="protein sequence ID" value="MST34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029731949" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="61" mass="6162" checksum="A837FCB24FD1E62B" modified="2021-04-07" version="1" fragment="single">MQFVLVALAAYAVGSLSGSAAVTWALVAAAILVAYLWSRRRPAACGVPGMRRQAGTAGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS0</accession>
    <name>A0A7K0JVS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_14845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000799">
        <property type="protein sequence ID" value="MST33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="34167" checksum="8D5E4072ADBEDC8C" modified="2021-04-07" version="1">MLPTAVHSGPPAPRLAAGDAIVTEGLTKRFGEVAAVDGVGLQVPTGSVFGFLGPNGSGKTTTIRMLLGLISPTAGSWSLLGREMPAAAEAALPRVGALVEGPAFYPWLSGRDNLARFDAAVPDGQRATRTARLDGALARVGLTAAAHKRYRAYSLGMRQRLGLASALLRPRDLLILDEPTNGMDPQGTREIRNLIRDLASDGTTIFLSSHLLSEIEQVCTHAAVMSQGRLLAQGTLADLRAAGEARVRVGVDDPTRATGILGRLGLRDVVASDGHVSARLDAGGPVDAARCCRALVEGGVEVSSLATVRPSLEDLFVALTGEGFDVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU3</accession>
    <name>A0A7K0JVU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000687">
        <property type="protein sequence ID" value="MST33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="289"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="679" mass="72854" checksum="52496AF3F577C719" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW8</accession>
    <name>A0A7K0JVW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000850">
        <property type="protein sequence ID" value="MST34096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="80"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25624" checksum="6A208E7C17AAB7FA" modified="2021-04-07" version="1">MTAAGDHRGGGPIIGRVAELWRYPVKSLGGERLACATLEPRGMAGDRLWAVRGEDGRIGSGKTTRRFRRMPHLLSLTAHTDTDGVVWIAFPDGPPGRADDPETAARVGEVTGAHVDLGEDDGAAHFDDAPLHAVTTADLADLQASRDDAAPADPRRFRPNLVIEAEAPLAPASRYLIGEDATVATTGPTARCVMTTMAQPGLAFVPGILRHLEERYDGCFGVYATVERPGDVAIGDPVTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW70</accession>
    <name>A0A7K0JW70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000889">
        <property type="protein sequence ID" value="MST34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="418" mass="42041" checksum="1A300C45463AE910" modified="2021-04-07" version="1">MTCTAGSHDHVLSVGPQALRSQLSPPIAYLTAAFTIGLALFASATPSPLYGIYGSLWRLSPGEITGIYATYALGVLVSLLLAGRVSDEVGRKPMLLVAVGGIIVSTALYMLADSAMWLAAARLLQGVATGLALSTASAALLDLHPRHDAAATGIANGVASASGSALGLFVSSLVVQCLPDRRILPYAIQGALLLVLAFLTRRLPEPSPRRPGPRVHLTPAWPNVPVSIRPPFTLAALAVLSSWMLNGLFLSLGPTLASSILATSSVLGSGIVVASLSGAAAVAMLLSGRSDPRLSASRGSLTLAAGAGLMTVAAACSSAPLFIVATIVSGAGFGVTFLGGLRSLSAAMPAAHRAGIMSAFYLVAYGAVSLPSIAAGLLVSVLGLRSTFEYFGGSVALLALAVSAAANVQGPSRAPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF0</accession>
    <name>A0A7K0JWF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000919">
        <property type="protein sequence ID" value="MST34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="19762" checksum="2871D805AE8D6C18" modified="2021-04-07" version="1">MTEDKRSSGASQTREALLDAGAALAEEHGLAGVSVNMVVERAGLAKGTFYVHFKDRAAFVDAMHARFHARVEAAIAEAVAGLRPGSERLYRVAETYLDASLENRGVKALSFEVRSDPAGQASMAARRERLAEAGIPDLEAMGWNDAPAAAQLLAAMIREISALEFDAGQPLPAARRTLRRFVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF6</accession>
    <name>A0A7K0JWF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000764">
        <property type="protein sequence ID" value="MST33894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="412" mass="43641" checksum="9BCA1F5CBA5C38BB" modified="2021-04-07" version="1" fragment="single">MTIHDELLARHRAVMPDWLGLYYEHPIALVGGAGCWVDDAEGRRYLDFFGGILTTMIGHNVPEVVEAIRDQAGRILHTSTLYLIEPQIELAERIAARSGIPDARVFFTTSGTEANEAALLLATSKRRSNQVLALKGSYHGRSYATMGVTGNRSWSASGLSPFVVSYVQSGYRFRSPFAGLDDAAFSEVCVADLRMVLDTTTSGDVACMIAEPIQGVGGFTIPPDGLFGRFHEVLAERGIPFVADEVQSGWGRTGEHFWGIEAHGFVPDAMTFAKGLGNGVGVAGVVASPELMAAVGANSISTFGGNPIAMRAALATLDYVERHDLQANAKVVGARVKEGIERIAKAHETIGEVRGRGLMIGVELVRPGTTDPDPAAASGVLEGARRAGLLIGKGGLYGNVLRIAPPLTLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV0</accession>
    <name>A0A7K0JWV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYZ2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001003">
        <property type="protein sequence ID" value="MST34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="47"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="21279" checksum="0EC0E3DB76782331" modified="2021-04-07" version="1">GPAPHVDPLGGPTILGPPVLTARELAAWYAQSGQHPHVTVPMAELAADYLRAGRRLGVRGDVAFAQSIVETGSFGFPAGGQLTGADNNFAGIGACDSCAHGWRFRSALTGVTAQLELLEAYATPHPVATPLVGPVGVGGCCTTWMGLAGHWATNPAYGIAILDVYTQMLDWTFPRRLVEVGLLPPSRSSPPPSGSSPPSARTTTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW0</accession>
    <name>A0A7K0JWW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001006">
        <property type="protein sequence ID" value="MST34438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="9177" checksum="8F7C7FB78F7C54A3" modified="2021-04-07" version="1" fragment="single">MGPDERLRRYQEVGADFLETARARAEEFLRDIGALGEATGRQAGTTVGDLRDSGRRGTDQLFELIRREIAAQLSGLGLATKADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX2</accession>
    <name>A0A7K0JWX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_17200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001013">
        <property type="protein sequence ID" value="MST34450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="13945" checksum="94D21969DC309359" modified="2021-04-07" version="1" fragment="single">TAGGWLAGALVAVGALASFTMGGNDVANATGSLVGTHTFGFLVAGAVGGVGLAAGVLTWGRPLLRRVAFEIVTVDRPMATAAQLVQAGVVLAAVGFGFFTSMNQALVGAMTGTAAARGRHTVRAATLLGILRGWVIGPGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX03</accession>
    <name>A0A7K0JX03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001020">
        <property type="protein sequence ID" value="MST34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="26305" checksum="9A9750890AA41442" modified="2021-04-07" version="1">MYDAVLAETVNLAGHGGDVIEAYTARPLAAGPFGGVVVIHHMPGYDWASKEITRRFAVEGYNAICPNLHYREAPGASPDDAAAANRAAGGVPDDRFVGDAEAAMNWLKRLPNANGRVGTIGYCSGGRQSFLAACRLPLDAAVDCYGAFVVGTPPEGLGIKLTPILDQAEGIDCPMLGLFGAEDTHPSPEDVAAIDKRLSELGKEHDFHTFEGAGHSFFSVDRPAYRVEAANKGWELIWEFFGRTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX80</accession>
    <name>A0A7K0JX80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mismatch-specific DNA-glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001069">
        <property type="protein sequence ID" value="MST34553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="8799" checksum="429146C2118CE5C8" modified="2021-04-07" version="1" fragment="single">MAAGPVPDLLGPGLSVLFCGINPGLRSAELGLHFARPGNRFWKVLHQAGFTDRLLDPAEQAVLPSLGIGITNLVPRASAAADALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX97</accession>
    <name>A0A7K0JX97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001078">
        <property type="protein sequence ID" value="MST34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="92"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="370" mass="39776" checksum="E4CEC95D5FA278B0" modified="2021-04-07" version="1">PPPDEHGFPDAILSVVGQVVAYDSWRQRVTLVDAVRIPPGTTPVAAGALWDAAVGRLEELAALGAEPLDEPLVVPPERDDELPEHRRRTDPAAYATAVAAAKEHILAGDIFQVVLSQRFELDLGAEAFDLYRSLRQVNPSPSMFFLRHPELCLVGSSPEPLVQVQAGRVVSRPIAGTRRRGRTDEHDRRLAAELVEHPKERAEHVMLVDLARNDVGRVVDYGSETVDELMTLERYSHVMHLTSQVSGRLRAGLGPVDVLAATFPAGTVSGAPKVRAMQIIDELEPVKRGPYAGVVGYFDFSGNLDTAIAIRTMVVAPDGTASVQAGAGIVADSDPADEDLECRNKAAALLAAVPGARRISAARRQAVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH5</accession>
    <name>A0A7K0JXH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001125">
        <property type="protein sequence ID" value="MST34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="18443" checksum="22F1BC695ADA170C" modified="2021-04-07" version="1">MSLSDYVIDIGLIALVLLQIRGRRLTTWAFLLPLVLVAWAAASYLHGIPTAGNDLPLVALATASGAALGVGAGLTTAVRRGADGTAVAKAGAIAAALWVLGVGTRLAFQLYATHGGDQAIGRFSVAHHITSSEAWVAALILMAFGEVIGRSAVLLVRTLRLAPARPVAVEAVLQHHGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK3</accession>
    <name>A0A7K0JXK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001146">
        <property type="protein sequence ID" value="MST34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="311" mass="34251" checksum="5934818E22D6BD21" modified="2021-04-07" version="1">MALGASASGRGASQAAIEHHYDVGSDFYGLWLDQRMVYSCALWDDALDDRLDEAQLAKLAWHATGARVDGAARVLDVGCGWGAMLRYLTASRGVGHAVGLTLSRDQASVATGSPTGSPGGSIEVRLEDWRDHRPAAPYDAIVSIGAFEHFARPELDAEQRRAVYASFFAACAGWLRPGGRLSLQSIGYEDFDPDTSEVSPFFTNEIFPESALPLLTDIVAASDPWFGVAALRSDAEQYEHTLHLWQRRLEANRSAATELVGAATCRTYLRYLRVSRAMFDRRVCTLYRIVLERRPQPVRRAHPLPPAEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL1</accession>
    <name>A0A7K0JXL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001153">
        <property type="protein sequence ID" value="MST34691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="25907" checksum="F304D1938D9542D8" modified="2021-04-07" version="1">MPAPSPTILATSGGTRSGARTALELAPLVHYGFELAGVSGRRPKLCYVPTAGGDQDYRIAWLHDAGRAAGVDVTHFTLFPMPNTADPAALLGDADLVWVGGGSVANLLAVWRLHGLDVVFRELWRQGVVLGGVSAGSICWHIGGTTDSFGPDLRPVTDGLALLPYANGVHYDSEAQRRPLFQRLIATGELPEGYATDDGVGLVYRDTRLVEAVSEVRGKGAYRVAPDAGGVVEERIEPRLLPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL5</accession>
    <name>A0A7K0JXL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001164">
        <property type="protein sequence ID" value="MST34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="56" mass="6159" checksum="CE4B4445ED824FD7" modified="2021-04-07" version="1">MLANLSRANEYQAELRMEAERRRLVRKARATVVAAGRGHLALAGTSVLAAGRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP7</accession>
    <name>A0A7K0JXP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001178">
        <property type="protein sequence ID" value="MST34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="72"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="180" mass="18362" checksum="A1541B851E4CA8A2" modified="2021-04-07" version="1">QQVGALHAAANLAAAGGWALSWRLRKRHHAAGVLAGLAATTAAATGGWLGGHLTYAMGVGVDTNAFSAGPSTWTAYPAPVEAGTMSAATVAGATLAATRLADGPAVLSGRCSHRGGPLGDGEVSDGCVTCPWHGSRFDLRSGQVRRGPAVRPQPVYETRDVDGAVDVRRAEPRSMRTNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR6</accession>
    <name>A0A7K0JXR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001146">
        <property type="protein sequence ID" value="MST34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6319" checksum="04B60385ACCE8450" modified="2021-04-07" version="1" fragment="single">MGSQDRAQRTPAPAARPGAQPARLGGSEAQLLRLQRQAGNAAVTDLLRVQRLWGRDGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY9</accession>
    <name>A0A7K0JXY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein HesB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001238">
        <property type="protein sequence ID" value="MST34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20791" checksum="6C09000BC643808E" modified="2021-04-07" version="1">MLHLAQDDAADQLLSEDPLALLIGLVLDQQIPLERAFASPRDLRDRLGGRLSVEDIAAMDPDALAAVFAERPALHRFPAANARRVQELCRLIVDDYGGRPADIWATAADGAELYRRIRALPGFGEQKARIFIGLLGKQLGVRPPGWEQAAGKFGQPGTFLSIADIVDEESLGRVRAYKQQMKAAAKQAQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG9</accession>
    <name>A0A7K0JYG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_20045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001358">
        <property type="protein sequence ID" value="MST35008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST35008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="480" mass="50938" checksum="2F1E458DB7CE7B0A" modified="2021-04-07" version="1">MASLDTALDDAPLSRFHTRAIVTAGMGFFTDAYDLFIIGTATTLIAKQWNLTSSETGLVNSITLISAFIGAFFFGRIADVVGRKKVYGLEAGLMVFGAVASAFAPDLITLLIFRFILGIGVGGDYPMSAVLMSEFSNRKNRGKLVGLVFSMQALGTVSGYIAGLALLGAGVPNDITWRLLLGLGALPAAAVIIQRRRMPESPRYLARVEGRSQEAAAAVRTFSDGAVTAEAAPDGRGRRLSLWAFLSNRRYLTILLGTAGSWFLFDYAYYGNSVSAPLIVSSVLGSAASKDLIHVLALQLIVFTVAAVPGYFLAAYTMDRIGHRRLQLIGFPLMGLAFLLIGVIPGITTAIVPFLILFGMSYFFAEFGPNTTTFVLPGEVFPTSARTTGHGLSAGFAKVGAFIGVYVFPIIKSDFGVNGALRLSALFALIGFLLTLLIPEAAGRSLDEISPEDVVDSAEQIVAGGDPGRLDQRQGARATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH1</accession>
    <name>A0A7K0JYH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase</fullName>
            <ecNumber evidence="2">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gltD</name>
        <name evidence="2" type="ORF">GHK86_19985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001349">
        <property type="protein sequence ID" value="MST34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="34374" checksum="549D1915381F40CF" modified="2021-04-07" version="1">AAAQQLARAGHDVVVWERADRPGGLLRYGIPEFKMEKRVLDRRLAQLRAEGVEFRCGVDVGRDLSAGELRSAHDAVVLAVGSTVPRELRVPGRELAGIHQAMEYLPLANRVQEGDVAVAPITAAGKRVVIIGGGDTGADCLGTAHRQGAVSVHQLEIMPRPPDARDPSTPWPMWPLVFRTSSAHEEGGERVFAVETEAFEDDGTGHVAGLRAHEVRWVPASGDRPARFEAVPGTVQDLPCELVLLAMGFTGAEPALPAALGTELGPRGTVARDGYATSVPGVWVCGDAGRGQSLIVWAIAEGRSCAAEVDRALTGRSLLPAPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH3</accession>
    <name>A0A7K0JYH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001361">
        <property type="protein sequence ID" value="MST35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="26113" checksum="33B789AB512C4519" modified="2021-04-07" version="1">MHEPAAHRDELGAGAVLVTGAASGIGLATATRCHEQGWAVGLLDRDEERLGAALATLGAAGAPPVAAEAADVTDAAGVQVAVDALAGRLGRLDAVVNAAGIGGYTGDVVATTPERWERTIAVDLTGVYLVSRAAVPHLRAAGGGRIVHVSSQFGLVGAAGSPAYVAAKSGVIGLTRAMAVDHAAEGILVTCVCPGPIDTPMLRASHADGSVAARAESERTAHRSLLGGPGRPEDVAGTVLFLLGPDAAHLTGAVLAVDGGWTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK8</accession>
    <name>A0A7K0JYK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001114">
        <property type="protein sequence ID" value="MST34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-oxidase_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17379" checksum="A5AD20E09C6D65A4" modified="2021-04-07" version="1" fragment="single">TDAAAVLLAEVDGLPDGVASAAERIAEIGRAHGATSVRVAADDAERAALWKGRKTAFGAVAQIAPNYYLHDTVVPRSALARVLEEVYAIAERHDLLVVNVFHAGDGNLHPLLLFDRREPGVMDRVLAAGAEIVAASLDAGGVLSGEHGIGVEKRDYMAMLFSPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL0</accession>
    <name>A0A7K0JYL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_20185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001377">
        <property type="protein sequence ID" value="MST35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="158"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="359"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="621" mass="66456" checksum="67CCA6BE263D3946" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV7</accession>
    <name>A0A7K0JYV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001454">
        <property type="protein sequence ID" value="MST35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="26040" checksum="6DD1C1EEC8DFB523" modified="2021-04-07" version="1" fragment="single">PLRRGGRLVHTGRPTPEGYADAVVNRGGTLCFGVPTVWGRVAQSPVAGALRAARLLVSGSAPLPVTVFDAVEARCGHQLLERYGMTETLITLSGRVDGTRRAGSVGGPLAGVAARVVGEDGAAVPADGESIGGLQVRGPTLMTGYLGRPADTAASFTPDGWFVTGDAVTVGPDGAHRIVGRASTDLIKTGGFRVGAGEVEATLLAHPGVREAAVVGEPDDDLGQVVVAYVVTEGDAGDLGAWVGERLAAHKRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW6</accession>
    <name>A0A7K0JYW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_20690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001459">
        <property type="protein sequence ID" value="MST35136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="17264" checksum="F6A6494CC521BBDB" modified="2021-04-07" version="1" fragment="single">RRGLLLAVPFFAGFGAFMFVYALITQDRLGWSPLVAGLALAPLAAAFLLASLLMPRLVARFGRTVITAGALLQLAGLVGLIGSLSAVWPAVGAADLVAAFAVIGLGQGLVMPALVRIVLSEVPVEEAGVGSGALTTTQQVSLAVGVAVLGSLFVALAPAARLGALHAADLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ38</accession>
    <name>A0A7K0JZ38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="4" type="ORF">GHK86_19115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001240">
        <property type="protein sequence ID" value="MST34824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="28614" checksum="79523F3DB2B56A7D" modified="2021-04-07" version="1">MTRPRRSEASSPGRKARTSGVTWSCSPPPTAPGARPTPDGDHPPTGDSPSACPPTGPVLAAADAELLLDLLGEAQRRGFLGPGPIQAHLPHSLAFVRAWSLARTHPPHRLLDLGSGGGVPGLVLGRVWPEAHLILVDANLRRTAFLEEAAARLDRPGRTDVLIGRAEELAHGQLRERCDYVTARGFGPPPVAAECAAGFLAPEGLLAVAEPPTPESSRWPGEGLRRAALTAVGRVEDPAAVAVFRRHGPLDARLPRRVGIPAKRPLWSVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ61</accession>
    <name>A0A7K0JZ61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001561">
        <property type="protein sequence ID" value="MST35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="293" mass="30771" checksum="A1E7CBC3B256A08A" modified="2021-04-07" version="1" fragment="single">TGLLQATLDTAHQVAALRGAGLSPSQVTAALQPVRLDQRRLHPGHTFELGAYLAAFASGLLLYSLIALYGVGVAQSVAQEKTSRTAEVLLAALPARLLLIGKVIGVGVVGMAQVAVVVATALVANAVVHDTHLPASLWTAIPMALLWFVLGYALYSFICAAAGATVARPEEVQLAVTPYTLLLVLSYLLTFVVGAIGNTWWLAVLSLLPPMAPVLLPARIAAVGVPWWQIGLAVAVELASIVAVARLAERIYVRTLLDTGGRVRMLAALRREAAGRAQQRGPFGSEEASAPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ62</accession>
    <name>A0A7K0JZ62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001551">
        <property type="protein sequence ID" value="MST35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="7506" checksum="5A1704DE2E468E6D" modified="2021-04-07" version="1">MTTLFAAPYRGQPLIPRGCSGTEFVPKIPVTCSYGPDGGAAPTTPLYQLLLEPHDHGWYVRQVIVEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD9</accession>
    <name>A0A7K0JZD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03560 family F420-dependent LLM class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001312">
        <property type="protein sequence ID" value="MST34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="26662" checksum="EA3BFAC62BD97153" modified="2021-04-07" version="1" fragment="single">MKLRIFVEPQQGASYDTLLAVARVAEAEGFDAFFRSDHYLTMGGDGLPGPTDAWVTLAGLARDTTGIRLGTLVTSATFRLPGPLAIAVAQVDAMSGGRVELGLGAGWYDDEHRAYGIPFPETAERFERLEEQLAVVTGLWATPVGQRFGFDGRHYHLADSPALPKPAQDPHPPVIVGGGGKRRTPALAARFADEFNTPFMLPAEAKAQFAVVDRACEDAGRDPATLRRSSALVVCCGADDAEVARRAAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE2</accession>
    <name>A0A7K0JZE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3071 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001563">
        <property type="protein sequence ID" value="MST35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="21999" checksum="4665CDE9FB13D101" modified="2021-04-07" version="1" fragment="single">GPEPERETSGPPATSPALPRPLPPDPAVFEAVATAGGLRSALTPREIQARLRQGRTVTEVAAEAGVGIDWIDRFAAPILAEQRAAVDRAGALRFTTARKGESALPLADAVQRNLLRRGIRVTADEIAEHWSAWHTGGSEWVVRLEYAGQQKSVKAEWLVDFAERTLSARSPLAAQLAFVEDISDEAQPAGTDVAASTPADTPPGTGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZM5</accession>
    <name>A0A7K0JZM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001684">
        <property type="protein sequence ID" value="MST35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="7989" checksum="8C6A97E90821C2B2" modified="2021-04-07" version="1" fragment="single">GLILATPLLLAALAAASRRLPLSPRLALRDAGRNRSASAPAVAAVMAATLGAVAAVVTTTSYTAHGRAGYQAVAPLGEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K031</accession>
    <name>A0A7K0K031_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">16S rRNA (Cytosine(1402)-N(4))-methyltransferase RsmH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="6" type="ORF">GHK86_20855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001483">
        <property type="protein sequence ID" value="MST35169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="30137" checksum="9C22A1DC34AD83F8" modified="2021-04-07" version="1" fragment="single">MSSAPVFGHRPVMLDEIVELFGAVPAGVLLDGTLGGAGHARALLEAHPGLRLVGIDRDPDAVAAASAALAGFGSRVTVVRARFADAARVLDDLGVEALSGALLDLGVSSWQLDRPERGFSYRAEGPLDMRMDPTTGPSAADLVNDLAEGELARILRAYGDERFAGRIARAVVAARPVTTTVQLAELVREAIPAATRRTGGHPARRTFQALRIAVNDELRSLPDALDALIGRLAPGGRIGVLSYHSGEDRIVKDRLRAAATGGCVCPPGLPCVCGARPTVRLLGRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMM7</accession>
    <name>A0A7K0JMM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000014">
        <property type="protein sequence ID" value="MST31175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="13120" checksum="BEE380C426F4F6BA" modified="2021-04-07" version="1">MSLEWEQTVVSSRDPASLGRWWQEALGWVVVNDDPAEFEIRPAPDRLPGLLFLPVPESKTAKNRLHLDFRPDDRDSEVARLLGLGAARVDVGQGEPSWVVLVDPEGNEFCVLSSWPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMR3</accession>
    <name>A0A7K0JMR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ISL3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="137"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="405" mass="46009" checksum="3F3F76ED9A0FF8C2" modified="2021-04-07" version="1">MNTPLGNNANVDTRPWCHRCGGPSRVKDRDAVVLADLPCFGRPARLVWQKFRLCCPDGDCEMGSWTWEDPRIAVARQAMTDRAGRWATWQVGRLGRTVAEVARELGCDWHTVNDTVLSYGTALVDHPDRIAAVVEALGLDETLFCRRGERHRQEFVTSIVDVSPNRPAQLLDVVAGRAASGPTDWINARPESWRAQIRWGVLDLSGPYRKTFDDALPDAGQVADPFHVIKLANHKLDECRRRVQNETLGHRGRKDDPLYRVRRLLTKAPERIDEKGEAKLLGLLDAGDPKGEVRDAWHAKEVVRSIYDIDDAALAEQFVCELAIDLQHEDRPIEVRSLGRTLARWFDEITNWHKAFVSNGPTEAIIIERIKRIGFGFRSLPHYRIRVLLYAGRPNWDLFPTITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX1</accession>
    <name>A0A7K0JMX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000032">
        <property type="protein sequence ID" value="MST31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="11808" checksum="BE645B0B94548E4F" modified="2021-04-07" version="1">MSGEPRDTWGGRPVARSVADVAARRRVVLAARVVAVRRTCWRSMPVLAVDVDDGSGRITAVFNGRDHVPGLAPGHPCRMEGTALPDGAGFVLWNPAVAPWPACADRAGGDGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX3</accession>
    <name>A0A7K0JMX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17649" checksum="7B8F6532F634D9DE" modified="2021-04-07" version="1">MALGIAIVGFIATVAAAFGGAWYGARLQRSSDTQHLALQLQIDSAARFIGSAGECIAAYGVAWAPGTENLAMTERQAPIFNAFVAVRTGGAAVGIVGPDRLAELADRFLKCAGEKGLTTSFDVNVVTELGTLLQQFIDKARELRPPTDPQHAVLEEHRTDAAVPRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMZ3</accession>
    <name>A0A7K0JMZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmC</name>
        <name evidence="6" type="ORF">GHK86_00550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="8362" checksum="0C1838FD7523ACDE" modified="2021-04-07" version="1">MTKPAELRDLNPDELEAKLVESREELFTLRFQLATGKQDNSSRMSQVRKDIARILTMQREREIEAAEAAEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN46</accession>
    <name>A0A7K0JN46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTPase ObgE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">obgE</name>
        <name evidence="8" type="ORF">GHK86_01390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000055">
        <property type="protein sequence ID" value="MST31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="160"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="292" mass="31006" checksum="72BF8136DDC34852" modified="2021-04-07" version="1" fragment="single">MPAFVDEAQVHVKGGDGGAGAVSFRREAHVAKGGPDGGDGGSGGDVWLVADRNVASLYGFRDHPHRRAGNGTHGSGKGRHGRGGADLEVPVPEGTVVRDRDGAVLADLAAEGDRWLAAQGGQGGRGNARFLSNRRRAPAFAEQAELGEERWLDLELKLMADVALVGFPNAGKSTLISRISAAKPKIADYPFTTLEPHLGVVRFDDQEYVVADIPGLIEGASEGRGLGHQFLRHIERARVLVVLCDLSAADGRPPGEQRDVLLRELRGYRPDLLDRPRLVVGSKLDAAPVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN52</accession>
    <name>A0A7K0JN52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000060">
        <property type="protein sequence ID" value="MST31400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="7883" checksum="16A75104F9DF5205" modified="2021-04-07" version="1">VLLALAGIRALVGAPTGPAMRPIAAQVVVVRPGQTLWSIAVAHDPPHTPLLAFLDRLEAETHGRPLQVGQQLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE6</accession>
    <name>A0A7K0JNE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="34501" checksum="9B143204F98D41DB" modified="2021-04-07" version="1">MIQQTTYREAIARALADEMAANQDVLLIGEDVGASGGVFKSTAGLYDRFGAMRVRDTPISEQAIVGAALGAAIMGLRPVAEIMFADFAGVCFDQIANQLAKYRYMTGGQARVPVTVRLANGSGAGFGAQHSQPAENWFLNIPGLKIVVPATVEDMYGLLRSAIQDDNPVLVFEHKSLFGTKGDIDDGLVVPLGVASVVREGRDVTVVATQQMRQRAVDAAEILAATGIEVEVLDPRTLVPFDDAAVVRSLERTSRLVVVQEASPDGSWGASLVARVASAHFPLLDAPPSLVAADPTPVPYAANLEEQWAPTTERIVAAVEKTVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG6</accession>
    <name>A0A7K0JNG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000056">
        <property type="protein sequence ID" value="MST31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="839" mass="90789" checksum="D7FEAEB7D9C915E4" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG7</accession>
    <name>A0A7K0JNG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secD</name>
        <name evidence="10" type="ORF">GHK86_01600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000065">
        <property type="protein sequence ID" value="MST31427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="512" mass="53234" checksum="A7BEFC4366214CF5" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ7</accession>
    <name>A0A7K0JNJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000076">
        <property type="protein sequence ID" value="MST31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="27277" checksum="3037D79D947AFF3B" modified="2021-04-07" version="1">MAAVYETTLVPPGGSQAAGVAWMDTRLLTARLYSGSISPGGGPYRYTAPVEPAQASTLVAAFNGGFKMSAAGGGYYTEGRLIDPLRAGAASLVIYRDGGIDIGAWGRDVRMTPSVVAVRQNLVPLVAGGRPTPAAAGPWQAWGNTCGATSCAASVPGIDHQWRSGAGITADGALVYVNGPALDPLQLAQLLVRAGAVRAMELDINPFWPVLATYDPSPSTGLAAPGNGRRLPPGSIQGPATFFEPWWARDFVTMSARPVAARGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK1</accession>
    <name>A0A7K0JNK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YraN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="11226" checksum="185E8BB8E34D6FA7" modified="2021-04-07" version="1" fragment="single">MPTASPPGGGAPTRAAHNRRLGSHGEDLAAGWYVERGYEVVARNWRCPDGELDLVVRQGRLYVFVEVKSRTSDAFGVPAEAVNRAKQSRIRRLAAQWLEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL3</accession>
    <name>A0A7K0JNL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">GHK86_02290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="216"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="330" mass="35261" checksum="52F9B41C09173100" modified="2021-04-07" version="1">PPPEVVEAEAEAAAAAVLVEPEVAEPEVAERPRLRDRLGKARSLFGGYLTTVRSRERIDESTWEALEEALILADVGADTALGLLDELRARVKAEKVTTPEELVTLLRDDLVERLQADRTLHLEPDVTNVWLFVGVNGVGKTTTIGKLGLQQRSEGRTVVMAAGDTFRAAAADQLATWAERVDVEVVRGNEGGDPGAVIFDAVQHAAAKKADLVLADTAGRLHNKVNLMEELKKVRRVAERPPGKVTEALLVLDATTGQNGLTQAKIFAEAVDVTGVVLTKLDGTAKGGIALAVQTELGIPVKLVGVGERAEDLVEFDPVEFVDALVAPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM8</accession>
    <name>A0A7K0JNM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">uvrA</name>
        <name evidence="16" type="ORF">GHK86_01905</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000079">
        <property type="protein sequence ID" value="MST31487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="603"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="742"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="643"/>
            <end position="650"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST31487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="946" mass="103979" checksum="8C8CA1547B750A36" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP8</accession>
    <name>A0A7K0JNP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aspS</name>
        <name evidence="8" type="ORF">GHK86_02380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000100">
        <property type="protein sequence ID" value="MST31578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="158"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="599" mass="65306" checksum="E4DF363E51CE0168" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR1</accession>
    <name>A0A7K0JNR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">GHK86_00515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="90"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="19400" checksum="72F4DBF794AE67B5" modified="2021-04-07" version="1">MSRIGRSPITLPSGVEVSLADRTVTVKGPKGTLRRDLPGAITVRQEEQTLLVERPDDERQNRALHGLTRSLVNNMVVGVTDGFTKELEIVGVGYRATARGAEQIELALGFSHPVVVDAPDGITFEVPAPTRIAVRGIDKEMVGQVAANIRKIRKPEPYKGKGVRYAGERVIRKAGKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV0</accession>
    <name>A0A7K0JNV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_02760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="473" mass="50023" checksum="D2BDEE53EE01282B" modified="2021-04-07" version="1">MGAEDVTFGGQMPSREGQAILEVHGMAPVPLANRYGRLFRVFTVWFTPNLVPAAFFIGTLATASYIGLGFWLGCLACLVGTIVGALPVSILATYGPRTGLGQLPLGRLQFGRAVVLPGVLQWVSTVAWDAINAIFGAQAVHLLLGVPFWVGLLAILALQGVLGLFGYELMHTFHKWMAGVLGIMFVVITVKIAEVGNFHARATAHGGNLVGGFILLATIAASFVVSWAAYASDYTRYMEPDASRRGIFVLTLAGVTVSSVWVEVLGVSVAAVAVNSTAAGLRHVVGGGALGALTLVAVWIGTVAVNAMDDYSGSLALQATGLKIKRPVIAVAVTAIAFVLTLWLDTGSLAAKFQNLLLFITYWIPPFAAIQMIDWHRNRGRLAVHDAMDVSRLRPGWDALIALLVGFGASVPFMDTTLYVGPVSSGPLHGGDIALAVGFFVGGAVYGLIRWVETRSWRQPVTAEPVVEAEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW5</accession>
    <name>A0A7K0JNW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="22165" checksum="D96342FD5F32CFA0" modified="2021-04-07" version="1">MRQAILDGEFAPRERLVEAELCERFAASRFSARVALQQLAFEGLVELQRNRGASVRAVSVAEAIEITLVRAALEAFCAGRAAELATEEDVAALQATAAAMRQAVGDNQVMSYSELNARLHGQIRTIAANPTCTRLLEQMRAQLVRHQFVLALQPGRPAVSLHQHIAVVDAIAARDKDAAERAMRAHLESVLDVLQAMPPSRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX0</accession>
    <name>A0A7K0JNX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nickel-type superoxide dismutase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sodX</name>
        <name evidence="2" type="ORF">GHK86_02870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000112">
        <property type="protein sequence ID" value="MST31670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014124">
        <property type="entry name" value="Pept_S26A_Sod_Ni_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02754">
        <property type="entry name" value="sod_Ni_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="9810" checksum="94BFE6E4B223121D" modified="2021-04-07" version="1">MTPTLEPGDRLLVVRARRPAPGDLVALPDPRDTGRLLVKRVAVVDGQRVTVLGDNAAASTDSRHFGPVPAGSVLGRVRYRYAPAERVGRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX8</accession>
    <name>A0A7K0JNX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_00845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000029">
        <property type="protein sequence ID" value="MST31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="359"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="695" mass="74306" checksum="63263B96811508E9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP05</accession>
    <name>A0A7K0JP05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_02895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000113">
        <property type="protein sequence ID" value="MST31675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="277" mass="28656" checksum="CB5B9302DB5F67CC" modified="2021-04-07" version="1">MTSGVDNGARPATGRAPGVSGGELLRLHGIQKHFGPVQALSDVTMSVPAGQVTALVGDNGAGKSTLIKTISGIHAADGGHMEWLGKRAHIRTPRDASNLGIATVYQDLALCDNLDIVANMFLGREPLSGLVLDEGSMETQAKRTLTELSVTTVRSIRQPVGSLSGGQRQAVAVARAVMQNAKLVIMDEPTAALGVSQTAMVLELIATLAGRGIGVLVISHNLSDVFRVADRLAVLYLGRLVAEGPIAEFDTQSAVELMTTGNRSGVSSGAAAGRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP11</accession>
    <name>A0A7K0JP11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ORF">GHK86_02775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="35264" checksum="0325C79273ACC9D2" modified="2021-04-07" version="1">MTQLNASGPIGPVDGTVVPRFAGAPTFARLPRIDEIHDYDVAVLGAPFDGGTSYRPGARFGPLAVRTASRHLRPAYHPDLDVAPFRTLQVADAGDVAANPFSITEAVDQIGRHASTLVSPGRRLVTIGGDHTVALPLIEAAHAVHGPVALVHFDAHLDTWGTYFGAPVTHGTVFRRAFERGLLVEDHSVHVGIRGPLYDAGDVERDAGFGFEIVRARQLDRLGCDAVAERIRARVGDCPVYLSVDIDVLDPAFAPGTGTPEVGGFTSRELLELLRLLDGLPLVGADVVEVSPAYDHAEVTALAAATVVYEIVSLMARTAAGDRPRLNGAATSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP32</accession>
    <name>A0A7K0JP32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000112">
        <property type="protein sequence ID" value="MST31673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="18711" checksum="E63C6DE2A18E323D" modified="2021-04-07" version="1">MTAGIVVFFVYTGLEVGAGQWETSFDRLHLHLSAPQAGLATFGYWGALTAVRIGLALLPRPLRHQTVIRGGTVAALAATAVIWWQPDTVTTLIAFAVLGGALAGIFPALIALTPGRLGDRRAQHAIAWQVGAASAGGAGLSAVIGGLIGALGLAVLGPAITALAVVLAIAELGLDRLAPAAAVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP41</accession>
    <name>A0A7K0JP41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029704641" evidence="2">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="31266" checksum="11AF98DEC7EBEA5A" modified="2021-04-07" version="1">MATSVTALLALAAAGGSAAAQPDRPSPHGHAHVEHFVAQGLVAGISGGKLSVLANVLRVGHHLERGVEITVKTSEARAGGRETGSGRGPAGRAPVVGDRVVVAGWVDPARPGDGYQAQSTSVAPAPATVVVGTVATTTPPSGASSGFTLSPLGDNQGSHPGGQSRDAVEADPGSGQPNGIGVDTSGATVTVDGTSGGTLAAGDVAVVVGESEADAVAAAQVYAFSTLPALLPGVVTAVGGSTVTVTAGDGSDQGNGTPVDLTGVPVVLDGTTGRTVADLQPGDRILVVGTTAAASSAGTAAMTPSLAIAFDHADHGPVGTNGGGGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP63</accession>
    <name>A0A7K0JP63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000042">
        <property type="protein sequence ID" value="MST31349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="11222" checksum="7F28E4BF0118FC6E" modified="2021-04-07" version="1">MMTARGRSRWWQRLQVFGEDDLLALAGRERLERGRVLAGTIDDLYEDEWSICGTVHDGKAYLAMVHHVGSPLSCECDCPDGAPGRWCEHVVAVGLCYLEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP81</accession>
    <name>A0A7K0JP81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000134">
        <property type="protein sequence ID" value="MST31782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="24233" checksum="FE1F26FAF4FD115E" modified="2021-04-07" version="1">MVSLVPSVTETLLAWGVVPVGVTRFCEHPELPAVGGTKNPDLERIVALAPDLVVVDREENRRPDADALTAAGLALHVTHVRSVADVAPTLAALREALGLGEGKGSALPPPAQPERPVRVYVPIWRRPWMSISGATYGSSVLAAAGAHNVLAGHPDAYPAVGPNEVAALRPDAVLAPSEPYPFAARHAGLFAGLAPMVPVDGKDLFWWGTRTPAAVARLRGVVGSVSARCRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC5</accession>
    <name>A0A7K0JPC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000144">
        <property type="protein sequence ID" value="MST31816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="33202" checksum="D4E4968C042348E2" modified="2021-04-07" version="1">KDPSASLLLAELWQEAGLPDGVFTVLQGDRQAVDALIAHPGVAALSFVGSTPVARGIYERGAAQGKRVQALGGAKNHMVVLPDADVELAADAAVSAGYGSAGERCMAVSVVVAVGDIGDRLVGAIADRIPKIRVGDGADPDSEMGPLVTAEHRDRVAGYVDAGAAAGAAVVVDGRRADLPAGGFYLAPTLLDGVRPAMSVYTDEIFGPVLSVVRAATYREAVELVNANRYANGVAIFTRDGGAAREFQFDVEVGMVGINVPIPVPVAYYSFGGWKASLFGDTHMYGPEGVNFYTRGKVVTSRWPDPATSSVDLGFPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK5</accession>
    <name>A0A7K0JPK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000077">
        <property type="protein sequence ID" value="MST31484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="359" mass="38694" checksum="74D14FF8864B38D5" modified="2021-04-07" version="1" fragment="single">MNVALRIVAGLLGTAAVLVAVDSAVRSTVLPRAARSRFAQGVTRATRLVFHLIIGRSQSYERRDRVMALLGPVLLLALLVSWLLLVLAGFTALYAAQGVAGGARDVELSGASAFTLGTATPHGLANGILTYLEAGIGLLLVTLLITYLPSIYGAFSRREVGVNLLRARAGDPPRAATLLARYWRIDAGEVRLGELWRSWETWFADVEETHTTFAALPYFRSPQPGESWITAAGVLLDSASLWVAAVEHPVDPDAQLCIRTGFLALRRIATSLGLPSDDDPAPTDPISVARDEWDRALDELEAAGLPVVADRDVAWRAWSGWRVNYDLALLGLARLVEAPVAPWVSDRSPVRELLVPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL7</accession>
    <name>A0A7K0JPL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">4Fe-4S Wbl-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_04045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000169">
        <property type="protein sequence ID" value="MST31898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST31898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="23700" checksum="369D2A5EC2FD9D40" modified="2021-04-07" version="1">MPAVGGAEGGRGRCPRSPAGSLPRPPVALLQRDRRHRARSHHPGGRSGRRRHRRGRHGRGARLLAPDHPADPRRCPGHRGPGRCRRDAHRRTGALAAPAARPRGWLLPRLTDPHTSYSSWDDETSDLAELLELLDQRPTWHRHAACRGGMEGVDWFAPGAAGIERAKEACGDCPVLDECRAWALEQGPELHGVWGALSKQDRSAINGPGKAGRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU3</accession>
    <name>A0A7K0JPU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="72" mass="7727" checksum="AE49C71FC66148C8" modified="2021-04-07" version="1">MKVSVSLPDADVEFLDHYAAAQDLGSRSAALHRAVRLLRGAELAPAYEDAFVAWDDSGEAAAWDAPVGDQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ01</accession>
    <name>A0A7K0JQ01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">GHK86_04725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000199">
        <property type="protein sequence ID" value="MST32030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="27"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="21179" checksum="721D3E6A180F98D8" modified="2021-04-07" version="1">MDESYVEAVFEDTREKMARAVEHARGELAAIRTGRAAPALVEKLRVEYYGSDVPLQQLAGIQVPEAKVLVITPYDKGSLKAIEKAIQNSDLGVNPANDGVVIRLTFPPLTEERRRSMVKVAHTKAEDGRVAVRNLRRSARKDLEALEKDGDISSDELDRAEKELERMTHEYVAEVDRVLQNKEDELLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ44</accession>
    <name>A0A7K0JQ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Restriction endonuclease subunit R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015668">
        <property type="term" value="F:type III site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045572">
        <property type="entry name" value="RE_endonuc_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19778">
        <property type="entry name" value="RE_endonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ResIII" evidence="1">
        <location>
            <begin position="86"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RE_endonuc" evidence="2">
        <location>
            <begin position="870"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="981" mass="110455" checksum="7C038FAD65C9EA37" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ50</accession>
    <name>A0A7K0JQ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000205">
        <property type="protein sequence ID" value="MST32076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="15645" checksum="2362216648959684" modified="2021-04-07" version="1" fragment="single">MSAGPKQLGGEVVARSLAALGADTVFGLPGVHALAMWEGLRRIGLRGVGLRTELSATFAADGWSRVTGRPVPVLLSTGPGALNSLTGIMEAASSHVPVVAVISQIPSRELGRHGGWLHELPDQLGSFAPLVKWTARARSAEAVPGILAEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE2</accession>
    <name>A0A7K0JQE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplI</name>
        <name evidence="9" type="ORF">GHK86_03475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000136">
        <property type="protein sequence ID" value="MST31789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="16091" checksum="A07586ECF5481C4C" modified="2021-04-07" version="1">MTKVVLRADHDILGKRGDIVEVADGYARNYLLPKGIAIAATDGVTAQANAMRRARDLRDARDREAAETVARKLVPMVIRIPAKAGSGGKLFGSVTAGDIVDAVASQTDIEIDRRRLRLDEPIKALGTHEVPVKLHADVEFQVTVDVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ9</accession>
    <name>A0A7K0JQJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000237">
        <property type="protein sequence ID" value="MST32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="72"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="27834" checksum="F581970B05CC3CA0" modified="2021-04-07" version="1">MSSHGVADLGAVLDGHARLRWVQLPFAGIEQVAAAGVVTAERVWTCAKGCYAEPVAEHALALSLAGLRLLPERVGARSWGDPGGTSLYDRSVVILGGGGITAELLRLLAPYRVHATVVRRRADPVAGAARTVPTEALRTVLPGALVVYLALALTPATSGIIGAEELACMDREAWLVNVARGGHVDTEALTAALAGGSIAGAALDVTDPEPLPAGHPLWDAPNCIITPHTADTWEMVRPRLARRIEDNVARFGAGHPLIGLVDPEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ1</accession>
    <name>A0A7K0JQQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hopanoid C-3 methylase HpnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hpnR</name>
        <name evidence="7" type="ORF">GHK86_05930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027564">
        <property type="entry name" value="HpnR_B12_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00565">
        <property type="entry name" value="hopanoid_C3-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04367">
        <property type="entry name" value="HpnR_B12_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="178"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="491" mass="55877" checksum="438FE53A9215F448" modified="2021-04-07" version="1">MRVLLVHPGALMYSEIFLRLEPLGIERIAAALRGHDVRIVDLQVYDRREIDRQLREFRPEAVGFSLNYLANVPDVVDLAKDVKAALPTSLVFVGGHSVSFVAEQVLEHAEGAIDVVLKGEGETSAPRLLDAWPDRALSEVPGAVTMDGYGPPPKLLESLDDPLPARHLTGRRNKYFIGVMDPAASIEFTRGCPWDCSFCSAWTFYGRSYRKLSPEAAAEDMARIEEPGVFIVDDVTFIKAEDGHAIADELDKRKIKKEYYLETRTDVLVRNQEVFARWKRMGLNYMFLGLEALDEEGLKAFRKRNTPKVNLEALEVARKIGLTVAINIIADPDWDVERFEYVRAWAASVPEIVNITVQTPYPGTETWLTEARKLTTLDYRLFDVQHAVLPTRLPLHQFYEELVKTQSVLARKHLGFAALAVTARTAARHVLHGQTNFVKMLWKFNSVYNADRQFGEHQRPVRYSMPLPPEQPVLVPDRQEMYVHVPFRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ2</accession>
    <name>A0A7K0JQQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF222 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000174">
        <property type="protein sequence ID" value="MST31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="2">
        <location>
            <begin position="40"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="386" mass="40463" checksum="4621CEA4F06DD71F" modified="2021-04-07" version="1">MFDRLHRMVTTAVVEGGVAEDGPAGAEVLDRLPLERLESEICGLSSRLAAASCSLVLAIAAYDRRRGWEAWECRSMAHWLAWKVEMSPGAAREHVRVGHALEDLPVLREAFGAGRLSYSQVRAITRIATPANEATLVDWARSCTAGQLERLVAAYRGVRSARSARRAREGRGLWSQVGDDGMRVVVVRLPAEEAAGLEAAVEAEAERMWQERHRGRSESERAPGDDADLGVDADETAAGRRADALVALVARGAAAGPAVEASGVTAVVCVSAELLPTPPGEGGSAAEAPGPVAGSGLVCHTSRGDGIAVETARRLCCGASVVAASLAGASPLAVGRKTRVISPAMRRALQLRDGGCQFPGCGATVGVEAHHVRHWAMVGRPICPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR07</accession>
    <name>A0A7K0JR07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="432"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="975" mass="108945" checksum="99FBF4A4686F936A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC8</accession>
    <name>A0A7K0JRC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000222">
        <property type="protein sequence ID" value="MST32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="27945" checksum="1888923C30E78AD8" modified="2021-04-07" version="1">AATGAAHDALLVLSVHPRSAGRQLRAFGSGPPAVCALLRRELRLLAGQLRQADIEARAPLDLPQLARAVRTTYEPAARREGGMRGDVDAWPAAWKDGWSCARVDGRWQATYWIAEWPRREIGPDFLLPLLLTSVPRVVSVTMAPVPARAAVREAETARTAELADEELRRRAGFLSTARHRRRAEGVAHREAELADGHGELRFAGYVGVSGRTPEELEDATAAVEAAAQQCGLELRRLYGRQEEALSWTLPIGRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE9</accession>
    <name>A0A7K0JRE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_05415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000228">
        <property type="protein sequence ID" value="MST32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="31773" checksum="C42686FE03AE84AB" modified="2021-04-07" version="1">MPAPDAAAAAGRPPLTILDGGTGRELARIGAPFRQPEWSALALMEAPSMVARVHRAYVGAGADVITTNSYALVPFHIGEDRFAAEGQMLAARAGLVAREVADEADHPVLVGGSLPPVGGSYRPDRVDGGRSRLVLPRLIDGLEPAVDHWHAETLSAVAEAEIVAELTASSGKPLWLSFTLLDDGATAEPRLRSGESVGEAARAARDLGGSALLFNCSQPEVMLGAVAVASDVLQGRIPVGVYANAFPPQTADAEANDALHAVRPDLTPQHYCDFAAGWQGAGADIIGGCCGIGPEHIAALASLRSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG4</accession>
    <name>A0A7K0JRG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000318">
        <property type="protein sequence ID" value="MST32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="29365" checksum="D184ABC02B5F6898" modified="2021-04-07" version="1">MSCPLEDGQWADAYEGRLDGLGADASARGALPIPSRTPGALDATVTPADIRSTICVVGWTATVRPPESYTEPLKIRQLDTGYAFRGDHRLGDYEEDHLVPLELGGSPRSVRNLWPEPYHLAAGARVKDRVEDRLHALVCDGRVPLRTAQHAMATDWETAYRRWVGPLPVTPPTTFPPTTAPPGSGAGPTCRASVSDARPSDYSTVEVTVDTGVAGASVIATAHYRTTDTSHSVAAGSSGVARVAFDISGATRGYQVNVGVEVRAGGASASCRTSFIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ5</accession>
    <name>A0A7K0JRQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17402" checksum="37330B9635EAB88C" modified="2021-04-07" version="1" fragment="single">MQETAAEMAALQDLLAQSRRRSTEHLRSIVGEDRALSAAEVVAALGGMKVVSLATVTARGEPRVSAVDGHFLHGTWLWGTSGTSAKARHLAARPAVSLAHVDGETLAVFAHGTAHRLEPPDGRFGEAVAHLTGHYGLSPLELGPDIRLYRLEPAWMVGWAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR4</accession>
    <name>A0A7K0JRR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000346">
        <property type="protein sequence ID" value="MST32630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="375" mass="39415" checksum="79D12DECFFDB5CF2" modified="2021-04-07" version="1">MPRHPLAAVVLAAGEGTRMRSERPKPLHRLCGRPMVLHVLHALVGLGLERAVVVIGHGGDRVAKAVGDELPEGLAVEFVEQRVQRGTGDALSVAMTAFDDDPDEAGDVLVVPGDTPLLRATTLATLVRGHQETDDAATLLVARLEDPTGYGRIVRGRTGSVARVVEQGDATEEERAIDEVNTSVYVFRRSVVAPALRRLSPDNTQGEYYLTDIVGVLHDAGYGVGAVAVEDPIEVSGVNDRVQLARVEAELRRRVNLTWMARGVTMVDPAHTYLDVTVELAADVSLYPGTLLQGATRVERGAELGPNTHLADCTIGPRAVVTGTVGRGAEVGGDAQVGPWAYLPPGSRVPAGRITGPGFSASVEPEGPGPSGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS04</accession>
    <name>A0A7K0JS04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000369">
        <property type="protein sequence ID" value="MST32721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="79"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="32578" checksum="6E4171495049792D" modified="2021-04-07" version="1">MPPRSRSTARCSPTSPCATPPPSPPWWRWPARPCRRPTRPRPDRPERFLPALGYRHQRIQRLRRLSGRRSARQAEGAFVVEGPKLLGEALAAGAVESAYLAPGAGPTERALAERCLDAGARVFELEDGVLERVTGTVTPQPILGVAADPSRPLAAVGESAPSLVVVCADVRDPGNAGTVLRSAAAAGADAVIACDGSVDLLNPKTVRASAGALFRVPIVNGGAPEAVLDALAAWGLTRLGTAAHGGTDYLEVDLAAPTALVLGNEAHGLRPEVAGRLDGAVSIPMAPGAESLNVGIAAAVLCFEAARRRRVPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA1</accession>
    <name>A0A7K0JSA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000400">
        <property type="protein sequence ID" value="MST32821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="9776" checksum="C2A190D4145A7BF4" modified="2021-04-07" version="1">MSSVIADALLALGVLVIAASSVGVAVLDDPLHRLHLVTPAALLGVPLVAAAVVVRDGFDAAGFAAIAIAVVSVAASPFLAQALARSIEIRRRAARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF3</accession>
    <name>A0A7K0JSF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="26758" checksum="F6FD64007B6C4AE5" modified="2021-04-07" version="1">MTAGVCDMRLGRVSVGVLATGLGLAACGGGGVTTSSYRSVREAIVRSDGRTIVAEATWGGCQPRPHLVLRGGTSIIRVALTFPPPLSGNCTTEGRFAPVTATLPSPLQHRRLVQLTTGKAVPTVLEADLPKPRGLPPGYHLSTILPTVMAAGLPSGTLGATQTYQRSPASSPDLVLADVPGEHLPTAVHGWRSREITLGARPARLLVDQQPPPFVQRAVAWTAFGQTLELIARYRPGQPTLPQPALLATARSVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG9</accession>
    <name>A0A7K0JSG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">GHK86_09175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000421">
        <property type="protein sequence ID" value="MST32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="232"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="261"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_00563"/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MST32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="474" mass="51471" checksum="4F2D3FA2FF592AD2" modified="2021-04-07" version="1">MTDTLPAPAYRVADIGLADFGRRELDLAQVEMPGLMALRAEYGDSKPLAGARISGSLHMTVQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAWKGETLEEYWWCTTQALRWPDGGLPNMILDDGGDATLLVHLGVEAERSGEVPELGAEDSEEYGVILATLRRTLREDPTLWTRTAESIKGVTEETTTGVHRLYQRAAEGKLLFPAINVNDSVTKSKFDNLYGCRHSLTDGIFRATDVMLAGKTAVVCGYGDVGKGCAQSLRGQGARVIITEIDPICALQAAMEGYQVLTLDDVVETADVFVTATGNRDLITAEHMSRMRHNAIVCNIGHFDNEIDMAGLARVPGIRRDNVKPQVDAWVFPDGHAVLVLAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFTRTEQYPVGVHVLPRHLDEKVARLHLDKLGVRLTTLTDRQASYLGVDPGGPFKAEAYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH1</accession>
    <name>A0A7K0JSH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000315">
        <property type="protein sequence ID" value="MST32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
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    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="68"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
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            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32519.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="597" mass="61709" checksum="ED659E696257FF6B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ5</accession>
    <name>A0A7K0JSJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_09260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="8">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="435"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="713" mass="74617" checksum="AFDA310EF98987D3" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST5</accession>
    <name>A0A7K0JST5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redox-sensing transcriptional repressor Rex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000455">
        <property type="protein sequence ID" value="MST33012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Put_DNA-bind_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8952" checksum="0115B7659B1F4B3C" modified="2021-04-07" version="1" fragment="single">MSIRRLPEATVARLPVYLRVLTETTEGTISSDHLAAGAGVNAAQVRKDLSHLGSYGTRGVGYDVAYLVRQISRQLGLGADRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT23</accession>
    <name>A0A7K0JT23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000481">
        <property type="protein sequence ID" value="MST33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="476" mass="49826" checksum="0B4EE9D495FBCBB2" modified="2021-04-07" version="1">MVCGDLGGLEVAFREFASGFDAGLLTPGGAAAVVACCGRIEASVSAVRALAAARAAESGGWEREGYRSAADAMAAVTGTSAGAARRAITTGRRLAAQPEVAQAALSGALSAEQTEAVADGVAADPGSAGALLAKAEAGSLAELNEEVAAVKAAATDLEERRRELQRRRSLRRWVDRDGALHAHLFGHVEDGARLWRALDPIRRRLNVLRRQAGVRDSFEALDYDALVLLAKVAAGVEGELGFAELCELGLFPQHGEHCPSTPPGGGSSGPGGGGALSLFDDPAPPDGRGGNGDAAAPGGGPPARRVKKLAGSPAKIIVRVDLDTLLRGAPISGEVCELVGYGPIPVSVIEQLAAQDNAFIVGVLTHAERVLSVYHHRRRPNAAQRSGLEFLQPSCAAAGCNVKVGLQYDHRVEWARTHYTVFDLLDRLCPHHHNLKTRDNWALVDGTGKRPFVPPTDPRHPHHRGTDPASRGDPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT44</accession>
    <name>A0A7K0JT44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="8">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">asnB</name>
        <name evidence="8" type="ORF">GHK86_10300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000488">
        <property type="protein sequence ID" value="MST33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="637" mass="69600" checksum="45BA720C92BF8FF7" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF1</accession>
    <name>A0A7K0JTF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1326 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000527">
        <property type="protein sequence ID" value="MST33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="354" mass="37172" checksum="FAA012FA50591DC6" modified="2021-04-07" version="1">MLKGARMTICKRRSMDEIVSSRNRSARRCPSGGGGVLASCSDVGLSRVLSEVSATRFTSPRLVATEAFRAPPGVDRGGSHLPRRRASGPGVARAVRLGANPRRPSTGRRSAPERLGTFGPVRALPPDLGCKPPSGVPGVARGDGCNAPTSEGGWPVSWSIEGSYVENCNCDVVCPCTWSGFNRKATHERCLVLGGFHIDRGEIEGVDVSGLHFGLVIDAPQQMTDGNWRVGILVDEAASDQQAEKLQAVASGRLGGPITLFGPFIGEALGVARVPVSWQEADGRHQIRFGDVADVTLQDMESIEGKKMTLGNVPHPAGPSFTLSPSTASTVSAFGVSFGAPDTNGITTPFSWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU0</accession>
    <name>A0A7K0JTU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_09820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000456">
        <property type="protein sequence ID" value="MST33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="12859" checksum="135B31F8EF8F48EB" modified="2021-04-07" version="1">MRGQAQTGGAAVVDVEQRREGGWTVVRPVGDLDRFSSVAFQQEFADLAGTAVVVDLAEVPFVDSAGLGALVAGVRTVRGAGGDVAVVGARPALRRLFDMTGLDHFVRVLSTIDEVAAPAGLEGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU08</accession>
    <name>A0A7K0JU08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-II family nitrogen regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000586">
        <property type="protein sequence ID" value="MST33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="12273" checksum="6991FB0FEF71FD50" modified="2021-04-07" version="1">MRLITAIIKPFKLDDVKNALQEYGVSGLTVSEVQGYGRQRGHTEVYRGAEYRIDFVPKVRIEVLVDDDQAGDVIDLVVASAGTDKIGDGKVWSVPVDEVVRIRTGERGTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU30</accession>
    <name>A0A7K0JU30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000602">
        <property type="protein sequence ID" value="MST33456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="38"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="493" mass="50986" checksum="7979F4AD75C00BA8" modified="2021-04-07" version="1">MFEASVPANRSTTGWHRLLTEPARPRRIAQRPGAHWYAVAAVCIGAFMGQLDASIVTLAFPTMERDLHATVGAVQWVGLAYLLTLVATLTAVGRYADMAGRKLLYTYGFVVFIVGSALCGFAPDLPMLIGFRVLQAVGAAMLQANSVAIITAAVPADQLGRGIGIQGAAQALGLALGPAIGGVLISLGGWQLIFLVNVPVGIVATGLAWVLIPRSRHLSERATFDWLGLGLFAPVGVALMLALSLGGQVGWASPFELAMIVAVVVFTLAFLRREKRAAAPMVDLALLRIRAFWLGLVSGWLIYLVIFGVLFVVPYLLELGLHRSAAQAGVELLAMPLAIGISAPLAGRLADRTGARPLLLVGMALSTAGLVAMAFAHDSLPVLVVELLATGAGLGLSTAPNNAATMGAIPRTSSGVGSGLLNMARGLGTALGLALTGLVFTAFAGAHPHHAGPVLVGFHWAALLLAAASAAVVVLTLLRENGRLSDDPTAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU39</accession>
    <name>A0A7K0JU39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000599">
        <property type="protein sequence ID" value="MST33450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="5770" checksum="BF06179A1C703BBF" modified="2021-04-07" version="1">MKDRLPEHGAGVERTHDRVMITRHGRAAAVLISIDDLAALEAARLHPHVGPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU87</accession>
    <name>A0A7K0JU87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_12320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000616">
        <property type="protein sequence ID" value="MST33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="23876" checksum="B8A4CE1560907FD1" modified="2021-04-07" version="1">MSAAAEAGIDDAALLEALRAGDEASFEVLVCRHHRALFTLARSYVRSETVAEEIVQETWLGVLRGLDRFEGRSSLKTWIFSVLINQARARGRLEQRRAATSLDEGPPGDGPAEDPRRFVPPGDAFEGYWVTAPRCFGHLPEEQVTSTETLEAVAEAIRSLPARQREVITLRDVEGWSAEEVCASLGLSEANQRVLLHRARVRVRSVLEGHFAAEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU88</accession>
    <name>A0A7K0JU88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000622">
        <property type="protein sequence ID" value="MST33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="18097" checksum="F568DAE8F6F2C296" modified="2021-04-07" version="1" fragment="single">VAAVLAACDEAQVPVTPAAGRSGVCGGAIPVFGGVGLDLTGLAGIRSVDDTSLLVEVAAGTWGDDLEAALAADHGLTVGHWPQSMAISTVGGWVACRGAGQYSTRYGKIEDIVAGLEVVLADGRVVRTGGRAPRSATGPDLTQVFVGSEGTLGVVTAVRLRAHPTPPADGRRGWAWPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI0</accession>
    <name>A0A7K0JUI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnA</name>
        <name evidence="3" type="ORF">GHK86_12685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000643">
        <property type="protein sequence ID" value="MST33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="26830" checksum="135DF25E7BF58635" modified="2021-04-07" version="1">DDRAAAAAALIATRPTAVNLRWGVERALVADDPVAEARAVAAEDAARNRALGAFGAALLARGARVLTHCNAGSLACAEYGTALGVIRAAHEAGKQPTVWVDETRPVLQGSRLTAWELARLGIPATVLVDGAAGSLMARGEVDCVIVGADRIAANGDVANKIGTYALAVLAHHHQLPFYVAAPLSTVDPACPSGAAIPVEQRGADEVAVVGGRRLLPEGTAVTNPAFDVTPAELVSGIVTEVGIARAPYPSALVGLVAAGGGVRAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP8</accession>
    <name>A0A7K0JUP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000686">
        <property type="protein sequence ID" value="MST33672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="435" mass="46027" checksum="25FA4E565AF940FF" modified="2021-04-07" version="1" fragment="single">MPSRRPPARPGRTDTRSTPVAEREAPAGRSRPVGTTPGPAPEWGVARFVVACTPLHGHVTPLLAIMAELTRRGHEVIGCTGRRFANEVTGVGARFVPLPAEADYDDRRVEAVFGGSRPDGRLRRINADISRLLADPLPSQHRLLGRLVAEWAPAAVLVDTTFLGAFTWRSVQTTPHPPLAVANITFLALRGRGVPPPGPGLRPAPGLGGGTRDVLVRTVTDRLLVRRGLLRLDRAAREATGRAIPGLLFDGPRLADLVLVLTVPSFEYPRSDLPSSVRFVGPVQPPARAARTPPWWSDLDGSRRVVHVTQGTMDTSDLGALVAPTLRALADQDLLVVATTGGRPPEAVPGPVPSNARIARYLPYVSLLPRVDVMVTNGGYGGVQQALAAGVPLVVAGSGEDKPEVAARVAHSGAGIDLRTGHPRPAALRAAVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU1</accession>
    <name>A0A7K0JUU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000694">
        <property type="protein sequence ID" value="MST33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="96"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="30143" checksum="7894DF903175084E" modified="2021-04-07" version="1">MAPDPTPIVQHHLEALGRYPDPERATRVLAETMGVQPQHLLLTNGGSEAIALAGAVLGGTVEEPDFSLYPRDGGPLWRSNPNNPLGTLAPPAAAAGVWDEAFWPLATGTWTRGDHLRGAIVVGSLTKLLACPGLRLGYVLCADEALMLQIRRNQPEWSVNGLAAEALPDLLRPLDLPTWSARTSALRDQLVDVLRSHRLAVRAGHGPWVLVDRSGPLRAKLLTEGIVVRDCTSFGLGGTIRVAVPRPDQFGRLERALRHHCDTGSEPQPAPPEAETGKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV25</accession>
    <name>A0A7K0JV25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000733">
        <property type="protein sequence ID" value="MST33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="13245" checksum="09C7F873ED4A2776" modified="2021-04-07" version="1">MSKYTVNDAGVAHARELIEAHHYDLHTEWSEAAPSADQGNDEIDRHGYDGYGRWHLAVDTEASEGTKDRYGFPYGDFRRVNRAALIHAKQRASQNGHDQVAGAADRLLQQLDERAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF3</accession>
    <name>A0A7K0JVF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000773">
        <property type="protein sequence ID" value="MST33921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15711" checksum="FB301ED1A2F8E528" modified="2021-04-07" version="1">MTIGEPVSAGARSTRSAAAVIGRPHHVVIDCPAPHELAVFYSELLGLPITYRSERFVVVAESDHASGYAFQRAPGHQPPRWPDPSSPQQVHLDVMIDDLVEADRAVSRLGATRLAADAPVYADPAGHPFCLIPRPDWAPPVHPDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK1</accession>
    <name>A0A7K0JVK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000796">
        <property type="protein sequence ID" value="MST33980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16135" checksum="D79FB5E625EFB896" modified="2021-04-07" version="1">MYSVLAERQATARRSRSLRRMSLVAALLVVVQFGLGMGVNLYVAVPRGHPGSTGSDYFARSARSVGWAVGQGTPTLAAHAALGLLLVVMALVLAVRALTARAGAAGGLCVAAAALVIGAAFNGASFLDFGDALSSLLMALLGLGALVCYVLAAYSLGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW37</accession>
    <name>A0A7K0JW37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA topoisomerase IB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisom_I" evidence="5">
        <location>
            <begin position="83"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="37748" checksum="73484C1C0852CD04" modified="2021-04-07" version="1">MPRLRRSDPTAPGIRRRRAGRGFVYLHPDGTRVTDQATLARIRGLVLPPAWEDVWIAPWPNGHIQALGTDARGRRQYRYHDAWRAHRDREKFEHVVRFARRLPDVRRRCAEDLASPGMSRDKALGCAVRLLDLGFFRVGGDEYAEDNGSIGLTTLRREHTHLEGDEVIFDYPAKSGRHRVQSVVDPDVRTVIDELRRRRGGTRLLAYREGRRWHELHADDVNRYLRDLAGVPASAKDFRTWHATVLAAVGLAVSREAAHTPTAQRRAVRRAVCEVADYLGNTPAVCRRSYIDPRLVDAYLDGRTVAHALPRLGREGLPATRGAIEAAVIRLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB9</accession>
    <name>A0A7K0JWB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000913">
        <property type="protein sequence ID" value="MST34246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="6042" checksum="131075F6C2FD0D6A" modified="2021-04-07" version="1">GVVVGATFVGSDVAELLHSATVAVVGKVPLDLLWHCVPSYPTVSEVWLRLLEARRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG4</accession>
    <name>A0A7K0JWG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANTAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000933">
        <property type="protein sequence ID" value="MST34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="167"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26229" checksum="D22A6EA67D6F0A1A" modified="2021-04-07" version="1">MTREQTIIQTLVRIADNLVADFDVVDLLTGLADRCVDLLDIAASGVMLAGPDGELRLIASSNETMRIIEVFELQAAEGPCLDAYRTGSPVDQVDLGTAGGRWPHFAPAAREAGFRSVLALPLRLRDSTVGALNLFSDHTAPIPEPDLLVGRAFADLAAISIVQRKLMTEAQGLNEQLSAALHSRIVIEQAKGVVSERAGVTLPEAFARLRSYARARNLRLTDVAHAAVDGTLDPGAWNERAAGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG5</accession>
    <name>A0A7K0JWG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000762">
        <property type="protein sequence ID" value="MST33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10011" checksum="6308A1A1BA4ADCBD" modified="2021-04-07" version="1">MSEFGGVVMAFRRATVERGAIERELLGLAETAVTPPHSRTGAVFMAAQDGSLAAIASVGQRFVVLTETPPTGSGVLPLPGGRLAWDARQLVEHDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH6</accession>
    <name>A0A7K0JWH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GHK86_14450</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000770">
        <property type="protein sequence ID" value="MST33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="248"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MST33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="380" mass="40704" checksum="FBA1A0E4CC1BB5B3" modified="2021-04-07" version="1">MTTTDDSHHSTSFSVRPGAEGPGVGHADVPESLLPGTEEYVEDPRHYGIEHGVPWPEDVPRGQNDMHWRYEGDPRGARRAELRIAACWTVTMLCGIGLAWVYVAGGQAQVEGALLFCAFAGLGVGFVLWARDLLPGHDVIASRGGLTHVSDEADRRLAVQSLGRGLEPMARRPFLAKMLGGVLTVFGIGLLFPIASLGPRVKGQFAVTAWRRGIRAVSENGTPVRPSDIEPNGVLTVFPDTGEDLGSPAMAQSSVLLINVAFAPFQVQPGRENWHIGAVGSGDCIVGFSKICTHAGCPVSLYDWSAHKLVCPCHQSTFAVLEDCKPIFGPAPRNLAQLPLGVDSAGYIVARSDFNEPVGPGYWNRPIRVNPNTGAAVRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK9</accession>
    <name>A0A7K0JWK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000922">
        <property type="protein sequence ID" value="MST34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="4">
        <location>
            <begin position="274"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="441" mass="48597" checksum="195CA9740979B41B" modified="2021-04-07" version="1" fragment="single">MTRKVAVVPHTHWDREWYAGFPYFRLRLIEVMDQLLDRLERDPAHRFFLLDGQMAMVDDYLEVRPEAAARMRELVRTGRLSVGPWYVLMDEFLVSGETIVRNLQLGVTRAAGLGGHLPVGYLPDMFGHIGQMPQILREAGFAHAVVWRGVPRAVDRTAFWWRAPDGSTVRAEYLPAGYSNGASIPDDPDALLRRLRAHEAQLSPFLGEDAPLLFMNGTDHQAPQPWLPAVAAALNDEQKDFELRITPLSEYLANAPTEALPSWVGELRSSARANLLMGVASNRVDVKVAAARAERGLERLAEPLAALWIPAGEWPQQQLDLAWLEVIRNSAHDSICACSADEVGVAVLHRYADAATIASGVVEQVQRGLRGAFGRRGPVVVNPGQRTRSGLVELVLPGADAPAGMQLVDRVTAGSVEREARGRDLARVLAELTETGWLEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP5</accession>
    <name>A0A7K0JWP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000941">
        <property type="protein sequence ID" value="MST34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="30"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="20820" checksum="2E291A122B0BF3CB" modified="2021-04-07" version="1" fragment="single">MVNGDDAPSRVLIIVQNLPVPFDRRVWLECRTLVQTGVEVAVVCPKAPGDPTFELREGVELYKYAPRTATGGAAGYAVEYLWSFAATLALALRAARRGRFDVVQACNPPDIFWPIALLLRRLHGTAFVFDHHDLCPELFDSRFPGGSPAVRRALVWLERRTLRSADQVCSTNDSYRAVALVRGRLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ1</accession>
    <name>A0A7K0JWQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000971">
        <property type="protein sequence ID" value="MST34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="61" mass="6540" checksum="813582017F032011" modified="2021-04-07" version="1" fragment="single">MDIDHERLDPLRRGHGPIPEHVIDELVAGRLSRRQFLSRATKVGLGLPLAAAILEACGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU5</accession>
    <name>A0A7K0JWU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000962">
        <property type="protein sequence ID" value="MST34352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="58" mass="6464" checksum="1E84E377DC0D6CB6" modified="2021-04-07" version="1">MGIILLVLLLALILAGIGAVVHLLWWIAIVVFVFWLVGWAVARGEAAGSGRRRWYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX13</accession>
    <name>A0A7K0JX13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_17410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001034">
        <property type="protein sequence ID" value="MST34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="11">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="12">
        <location>
            <begin position="90"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="19124" checksum="43BB3E0F92A1007C" modified="2021-04-07" version="1" fragment="single">EPERRGLVPPRTILNVPITGSRRYAAQGWPLDEIRQVAKAAGGTVNDVVLAMCAAALRAYLLERDALPEDPLIAMTPVALRGHDGGGEGGNAVGAILCDLATDVADPAERLARIRESMREGKEVMSGLTPLQAAAYSALQVAPLALSAVRTLGGLVPQPFNLVISNVPGPARTLYLDGARLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX83</accession>
    <name>A0A7K0JX83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="12"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="28525" checksum="8C53F987BEAABFAA" modified="2021-04-07" version="1">MSRFPVLDHPGPLPIAHRGGSTEAPENTVAAFEHARRLGYDYVETDVHLSSDGVVVVIHDPVLDRVADRPGSVHGLPWPELRQARLGGSEGIPRLDELLAAWPGMRWNIDAKHDAVVTPLVEVVRRAGALDRVCITAFSDRRIALARRLAGPALCTSTGPAATTALRMASLVPGSPSLGGGPRRVAWGPAGAAQVPLRWGAVPVVDHRLVTVAHRSGLAVHVWTIDDEAEMDRLLDLGVDGIMTDRPTLLRDVLRRRGQWFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX88</accession>
    <name>A0A7K0JX88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GHK86_17800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001073">
        <property type="protein sequence ID" value="MST34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="9642" checksum="1FF0FA8533D96049" modified="2021-04-07" version="1">MSAQQLDDLWQGRAACRGPNTLIFFPPSHFERKDDREARETKAKSICGSCPVRRDCLDYALRIREPHGIWGGLNETERRVLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI0</accession>
    <name>A0A7K0JXI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001087">
        <property type="protein sequence ID" value="MST34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="5554" checksum="5B6EC9167AC2BC36" modified="2021-04-07" version="1">PKVRAMQIIDELEPVKRGPYAGPLSCVDGGMPGAAAGRGRRVLPPAGRGRALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK4</accession>
    <name>A0A7K0JXK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.399</ecNumber>
            <ecNumber evidence="7">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">serA</name>
        <name evidence="14" type="ORF">GHK86_18380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="6"/>
    <dbReference type="EC" id="1.1.1.95" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01001147">
        <property type="protein sequence ID" value="MST34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="13">
        <location>
            <begin position="336"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="404" mass="43430" checksum="93A463028AA8C7A2" modified="2021-04-07" version="1">MDDAPDQPRALLLEAIHPDATALLQEAGWSVETADRSLSDHELAGRLEGVQLLGIRSQTRVTEALLDKCPELVAVGAFCIGTNQIDLPAAAHRGVAVFNAPFSNTRSVVELVVAEIISLTRRLTEKDRAMHAGQWEKSAAGAHEVRGRRLGIVGYGNIGTQLSVLAENLGMAVFFYDTADRLALGNARRCSSLEELLASVDVVSLHVDGRPDNRNLFGEEEFAAMRPGSLFLNLSRGFVVDHASLRRHIVSGHLAGAAVDVFPSEPSGKGEPFVSELRGLPNVILTPHIGGSTEEAQVDIGHFVAHKLIDYAKRGSTALSVNLPNVELPERSGAHTFVHIHRNTPGVLATINAVFAEEGVNIEGQALGTRGDIGYVVSDVASDFSPDTRHRLAALEETIRLRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ9</accession>
    <name>A0A7K0JXQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000939">
        <property type="protein sequence ID" value="MST34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="195" mass="20893" checksum="436635B3FACA43E0" modified="2021-04-07" version="1">SLASSLAAAPVGRRLGTVRAISAVRLLGGALLVPMVLAPTFWLAGAVYFVRMLVQRIGLPLRQSFTQDMAHPEERASVAALSNLPAQAAQAGSQALAGYLFEEVSLAAPFELAAVLQCANAVLYTLLFAFRPPRPALQPSDPRRRPAEAPDRPQGEQHQPGQQVGHPAHVERPAHEWEVHQPVETPQRGELGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR0</accession>
    <name>A0A7K0JXR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit</fullName>
            <ecNumber evidence="2">4.1.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kgd</name>
        <name evidence="2" type="ORF">GHK86_18695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.71" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001189">
        <property type="protein sequence ID" value="MST34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008683">
        <property type="term" value="F:2-oxoglutarate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="11"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="207" mass="21651" checksum="AAA86DA99F9D5190" modified="2021-04-07" version="1" fragment="single">GPAPAPAPVGTPLRGAAARVVANMEASLEVPTATSFRVVPARLLEVNRRLLNEELSRTGTAGKVSFTHLIAYAVVEALKAVPALNSTFVAPDGADPKAPASVVRHEHLGLGLAVDVEKSDGSRTLLVPVIRDADTLDFRGFWLAYEDLIRKVRTNKIGADDFVGATVTLTNPGTIGTVQSVPRLMPGQGAIIGVGAIAYPAEWQAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU1</accession>
    <name>A0A7K0JXU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">GHK86_18915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001213">
        <property type="protein sequence ID" value="MST34785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="126" mass="13931" checksum="7913617805D371D1" modified="2021-04-07" version="1">MHVPDELRYTSDHEWVKLEGTKVRIGITDYAQDALGDVVFVQLPEPESRYDGGQTFSEVESTKSVSDIFAPLSGRVVEVNGELVDSPQLLNQDPYGEGWIALIEPDDAEAYGRLLDAAAYQTLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX1</accession>
    <name>A0A7K0JXX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001180">
        <property type="protein sequence ID" value="MST34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="25961" checksum="F4CD21462F8E36B7" modified="2021-04-07" version="1">MTAGWPSALWLVRHGESVGNAAAADAWRRGAEVVGVAPRDADVDLTARGRIQAEAMGRWLATLDDDRRPEVAVVSPYLRARHTLGIALDGLPGAVPVRVDERLRDRELGVLDRLTVRGIEARHPEEAAARRRQGKFYHRPAGGESWTDVLLRLRSALADLRADHAGQRVLVVAHDVVVVLFRYLLEGLDEAQVLEMSRRAAPLNCGVTYYEHEGGGLVLRNYNLAVDGEGRSEEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ2</accession>
    <name>A0A7K0JXZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_16885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000978">
        <property type="protein sequence ID" value="MST34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="24"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="704"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="818" mass="91814" checksum="3C7FB26A9811573B" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE5</accession>
    <name>A0A7K0JYE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001288">
        <property type="protein sequence ID" value="MST34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="7916" checksum="D7ED091D3C44E3F2" modified="2021-04-07" version="1">VDDTRFDLTPQERQIAELARSGLSNPEIATRLFVSPRTVEYHLGKVFAKLGIRTRGELQAVLGTGPGRGPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF4</accession>
    <name>A0A7K0JYF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001296">
        <property type="protein sequence ID" value="MST34912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="235" mass="23241" checksum="0350610AFE501C01" modified="2021-04-07" version="1" fragment="single">MGAPAAPTGRRVVGPRWRSLEGLPVGPLIAVLVLGAAMQLPSGLYDSLWSRMLTNRGASALLIGISLSVFGLPFIVLAPLGGRLAERRGPFLAAGLGLVGSDLFMAAYGFVPWPLLIVLLGVGEACVASVAIPGGFAAVGRVFPDDRMATGQGLFGGFGTIAAGSAAVIGAPVFAALGPGAAFAGGAAVSALLVGVAFLVWRSDGLGRRPVVAVASPSALAPVAGTETMMPAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ7</accession>
    <name>A0A7K0JYJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001094">
        <property type="protein sequence ID" value="MST34604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="355" mass="37270" checksum="CB385725911D819D" modified="2021-04-07" version="1">MTSATGGTAHGVSIGLSLYTGQADGGGPRFVDLPLLAAAAEGAGFDAFWVSEHHGFDDGYLPSPLVALAAAAQATSTITLATGVVLATLQHPVRLAEDAAVVDHLSGGRLLLGLGSGYLPAEFTRQGTPMAGRGRRLAEALEVLRLAWTGERFTYHGRLWSLEGVRVTPAPLRPIPVWLGGYADAAIDRAATTAGHLVGRASPELVDRADRRLRASVRAGDPTFTFGVMLTLAGDGPRAAGASARAAFARQQLGYERAQTEGDAYAGRLPRPAGDRLLLGGIDAYIQLRGDAATLVEGIVTTAASLRHWPSLHLSLRALYPGEETGLQVERVAWLGDEVLPEVRRRLGALQDVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK2</accession>
    <name>A0A7K0JYK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001383">
        <property type="protein sequence ID" value="MST35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="19093" checksum="1E937979AFB9B9CA" modified="2021-04-07" version="1" fragment="single">MDGRDLRLLPKAHLHLHFVGGMRHATLVEWADDRGIDLPLALRAGPPPLGGAQGWGRFQRLYDIARTVVRTESDVVRLLREVAEDDRAAGSGWLEVQVDPTSYAPLFGGLNPTLEVLLDAARRAAVATGVGIGVIVAANRTRHPQLASTLARLAARYTGAGVVGFGLSNDERAAGAAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK5</accession>
    <name>A0A7K0JYK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001369">
        <property type="protein sequence ID" value="MST35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041202">
        <property type="entry name" value="BaeRF_family10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18854">
        <property type="entry name" value="baeRF_family10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="356" mass="38332" checksum="EC6EB4A237DD81DA" modified="2021-04-07" version="1" fragment="single">MDASTARTTWPATAVSLPKVRRLCGHRGDPCTSSVYLDVDGAHRPVAATYLQAFGRLADELSRRARATGDERTVRSVEGDVDAMRTWLEQGVDRSDTCGVALFSCAAEAYFDVLQLDVPVHDEAAIATSPRVRQLVERLDEPAPFLVALVDHAHLRLLRVHDHHVEELPSLVSPPERAVDTSTEIGSWERHRAEAVRTHLRRAAHALDDAAGRRGAVPIVVGGPDDAVAEIQRLLHPTTTSLIVGRVRVRVTAAAPEVVAAARAVAEHAAHRHETDLVEELRQRVTGNHGAVAGILPTLDALAQRRVALLVVQHGFTIGGGRCPACGHVGLDVPRCPACGARNVLVDDVVEVAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL5</accession>
    <name>A0A7K0JYL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001332">
        <property type="protein sequence ID" value="MST34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="25806" checksum="DFC99723B3BB2D8C" modified="2021-04-07" version="1">MGPFSLEGRTALVTGGSRGIGAGIARALDAAGARVAVAGRHRGALDDVAAALSRGPVVLEADLADADAASALADRAVDALGSLDILVNNAGIGRRLPTEQLDAATIDALHAVNVRAPLLLIARLVPVMKAAGGGAIVNLSSVSGIVGTPNRAAYAATKGALDAATRSLAMELGPHGIRVNSVAPGVVDTQMWARNKAVPGVVEGVEAQTALRRWSQPADVADVVVFLASDAARFVTGETIAADGGMARTLDLYAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP5</accession>
    <name>A0A7K0JYP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integration host factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001403">
        <property type="protein sequence ID" value="MST35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="11604" checksum="F778473B681CCEBC" modified="2021-04-07" version="1">MPLPPTLSAEQRQAALEKAAAARRVRAELKEKLKMGSLSLRELLEQGDRDEVIGKMKVLAVLESLPGLGKVKARRLMEDVGISETRRIQGLGEQQRKKLFEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW1</accession>
    <name>A0A7K0JYW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001445">
        <property type="protein sequence ID" value="MST35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7281" checksum="D247BC241411A3A0" modified="2021-04-07" version="1">MADQTRPSDVTRAEEAREARAPADAGRGPTEEEARAADGHRPDPSTADHEEEMLRRGADQEGEGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ3</accession>
    <name>A0A7K0JYZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001201">
        <property type="protein sequence ID" value="MST34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14072" checksum="E45DDC24D8FC1223" modified="2021-04-07" version="1">MAELRVEGPDLVLALGPLERVGSFRGRDLRVPLSAVRRVRVPISPWIALRGWRSAGIAVPGWVAMGTRRHGEGWDFTLVRRSGPAVVIELNGYRFDELVVSVADAPATGARLAAAAGIAFDPTPDRGPLGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ82</accession>
    <name>A0A7K0JZ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001568">
        <property type="protein sequence ID" value="MST35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="27200" checksum="EDD60401A377C34D" modified="2021-04-07" version="1">MTGIESVNLAPPAVALAVGAHPDDVEFGCGATLAKWAAAGCRIHHVVCTDGSRGSWDPAEERATLVARRHEEQREAARRLGGGPVTFLDWPDGELEAGLRQRWQVAHEIRRVRPDVVLGHDPWRRYRLHPDHRNAGFLVTDGIVAARDPLFFPEQGLAAHRPTALLLWEADEPNHLEIVEGWEERKLHAIAAHRSQYRSTMGYGGPDGPTLEEEAAFRGRILGRLLQQGALAGRGPAEAFRLLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ91</accession>
    <name>A0A7K0JZ91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001579">
        <property type="protein sequence ID" value="MST35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="19602" checksum="08734731DBB134FA" modified="2021-04-07" version="1">RRRAPQATVVAGRAEMLPFAGDRFEAVTVAQAFHWFDVPRASRELRRVLRPGGRLALVTNRRRLTQPWLRELWAVVGRYERLAPRPPSSRTWRADLEAAGDFAGFERHRLPNLQRFGSLDEFDARFLSISFVILLAESDRRALLRDLHAVVAGVDPLVVPLLTEIEVATRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD6</accession>
    <name>A0A7K0JZD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001641">
        <property type="protein sequence ID" value="MST35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="180" mass="19335" checksum="94A4B5037D7DA61E" modified="2021-04-07" version="1">MPLVCRDQRVEVAVLVDVAEPGQERESLLAGIATVSPATSVCVLSAASHDIWLTYLGQGATGLLDEHAGPEVVTAAVRAIHAGTWVFSAEVARFLVRIAAGSPRGQHHLTRREAEVLRLVAAGAPNRRIAEMLDVSEKTVRNYVSRVYHKLAIEDRSQLVRQATATPDALLTAPTASTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG3</accession>
    <name>A0A7K0JZG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001582">
        <property type="protein sequence ID" value="MST35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="10558" checksum="8AB443E017823A84" modified="2021-04-07" version="1" fragment="single">VPGAVVTAGGAATPAQRWVAGCADTTPGVARPTTIDTRFDLASLTKVVATTVLVLGLVAEERLALGDPVARRLPGAAGGHPGVTVERLLTHTAGLPATVRLWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG4</accession>
    <name>A0A7K0JZG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001330">
        <property type="protein sequence ID" value="MST34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6110" checksum="9504EC34F923707F" modified="2021-04-07" version="1" fragment="single">MGRRRGAAVAVVRPGDTAEVAAVVAACAGAGVAVVPQGGNTGLVAGGIPRGGEVVVSTRRLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZU4</accession>
    <name>A0A7K0JZU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001690">
        <property type="protein sequence ID" value="MST35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="9052" checksum="87667BEC954F5AF2" modified="2021-04-07" version="1">MPDKKRWKDLSPRTRRLIVAAGTAETLLKLAALLDLRRRPAAAVRGSKVKWGTAIVVVNSLGVVPIAYFLYGRRPVDRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZY7</accession>
    <name>A0A7K0JZY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001442">
        <property type="protein sequence ID" value="MST35114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="30932" checksum="06FC960F45D26EBE" modified="2021-04-07" version="1">DHEDGAGPPQIPGLYETLDRTLGASLRRQIGLDQARVLVAAAAPSHPDLIRWFHAVGLPILDLYGQTEGCGPTTANRIGNVRIGTVGVPFPGMEVRVADDGEVLLRGGNVCLGYLDDPEGTAALLEGGWMHTGDLGAFDEDGFLRIVGRKKDLIITAAGKNVSPQGIETDLRNQPLISEAIVIGEGRRYLTALITLDPEELTRWAAAHHRLGDVEALGADPDVLAEVQAAVDVVNARRSHAEHIRRFQVLSRDLTGAAGELTPTMKVKRAVVYDRYRDVIDELYAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN02</accession>
    <name>A0A7K0JN02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000031">
        <property type="protein sequence ID" value="MST31283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="3">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="19596" checksum="BD95FA809A166220" modified="2021-04-07" version="1">GHALFIDFASDTTETVPLAGVGPLVVVDTGVRHDHTTGEYGARRRDCEAAAAALGLPDLRAADLAMVETRLSGRLAARARHVVTENERVGQAVARLQAGQEIGHLLSASHRSLRDDFEVSCPELDVVAEAVVRSGASGARMTGGGFGGCVIVAGMPEADVRVVASAALAKLGQVPAAVFEALPSGPAARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN99</accession>
    <name>A0A7K0JN99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="336" mass="34981" checksum="D575942A0BFFECE3" modified="2021-04-07" version="1">MTTQSLTRTPDAAPRRPGFRFRSEAERFAVVGAWIVIVVIFGALRPATFLTVGNMGTIFGSDAVLVVLTLGLLLPLRAGDYDLSVAGTLTLSAMMVGLLNGGHHDNIWLVMIAALAMGVVVGLINGLFVLIFGINPFIVTLGMGTLLAGIVLLISNDQTFAGISPGLVSAVVGDRFLGIPLEFYYGLVLCLFVWYLFEFNAVGRKLLFVGTGRNVARLSGIAVGRVRLGALVGAGALAALAGILYAGTSGSADPTSGTAFLLPAYAAAFLGATTIVPGRFNAWGTIIAAYFLVTGVTGLAILGLGSWVQDVFYGGALIVAVALSQLARRRAEQEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JND8</accession>
    <name>A0A7K0JND8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_2_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000081">
        <property type="protein sequence ID" value="MST31490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="PTHR43536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="21382" checksum="66EB5671991BF2D0" modified="2021-04-07" version="1" fragment="single">MDLGGRWLAARADEELRRRLPEPDLDDGGWEAVPVPGQWGLVPAFADSDGPLLYRRRFEAATPGPGRRQWLVFDGIFYQADVWLDGSYLGETEGYFAPHAFEVTDHLAARREHLLAVEVACAPQRDVRRKRNLTGVFQHWDCLPRSWNPGGIWAPVRLAETGPVRLRALRVSCREANAERATLELDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE9</accession>
    <name>A0A7K0JNE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">GHK86_01315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000048">
        <property type="protein sequence ID" value="MST31371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="32"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="468" mass="51168" checksum="6F7EC107A9EBBF66" modified="2021-04-07" version="1">MASPLTDPATDFPRWYQDVLVAAELADNGPVRGTMVMRPWGYAIWELVQGEIDRRIKAAGADNAYFPLLIPESYLRREAEHVEGFSPELAVVTHGGGKELEEPVVVRPTSETIINSFFAKWVHSYRDLPLLINQWANVVRWELRPRVFLRTTEFLWQEGHTAHATERDARDYALRILREVYLPTMVDLLAIPVVTGHKTDRERFAGAVRTWTCEGMMGDGKALQMGTSHELGQNFSRAFGTQFSTETGTLEYPWQTSWGASSRLLGAIILCHGDAAGLRLPPAVAPAQVVVVAVRDDEGAVTAARALRDDLAAAGHRARLDDRVDVGFGRRSVGWEIKGVPVRVEVGPRELAEGQVTLVRRDTREKATVPLGGVVAEVGRLLGEIQQALHDQALAAQRARTTRVATVEEAVEAGGAGWAVLDWDRLGPEGEDRLGAQALTVRCLQAPDGGLALEEGAGGLLAVVGRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF0</accession>
    <name>A0A7K0JNF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="463" mass="50098" checksum="042C574DB56DA15C" modified="2021-04-07" version="1">MTTTQGETPTDAAADPATGVEVLDLDRAHVFHSWSAQRTLTPLPIARTEGTAVWDYDGRRYLDFSSQLVYTNVGHQHPRVVAAIQEQAGRMCTIAPQHANDVRGQAAQRITARTPAGLDWVFFTSTGAEAVENAIRMARLHTGRRKIISTYRSYHGNTAAAIVATGDPRRWPNDVGIAGHVHVFGPFPYRSPFWSADDAEECERALSHLRQVIEFEGPETVAAILLESVPGTAGVIPPPPGFLDGVRQLCDEFGILWIADEVMAGFGRTGSWFAFQHWGAVPDLISFAKGVNSGYVPLGGVILSQAVYESFLDRPYPGGSTYSGHPLACAAAVATLDAMEEEGMIEHARKLGEDVVRPGLQELADRHPVVGQVRGLGMFWALDLVRDRSSRQMLVPYNASGAANAPMAELAAACRRRGLLAITSQNRLHLVPPCNVSVDELTEALGAVDDALGEIDHYYTGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF5</accession>
    <name>A0A7K0JNF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000073">
        <property type="protein sequence ID" value="MST31468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029688499" evidence="1">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="27551" checksum="B4D8F464EFBD82D6" modified="2021-04-07" version="1">MTAALVALLWIPIYTTKASAARPTAVCFPSPTGGVICGGDKGGGGQSGTSGSSGSSAPLTGQVWIQIGNLLAASAAHPECWVWMADNVTGDSQATIRQIEQFWAKVEQIFPPCPGVAATTASQWASEYWTAYWYGRQLPRPQPSVPPGYAITGLPAYLVCGDGALVTVDRGTPLGELTITARASYDVAWGDGTTSDGLTGPCTRWPDGTVQHTYDNVGTYTVTVDETWHVTWALGGANGAFADVQTTGTLPGLRVRQVQAVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW4</accession>
    <name>A0A7K0JNW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000111">
        <property type="protein sequence ID" value="MST31662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="32311" checksum="E0BB764742169D47" modified="2021-04-07" version="1">MSSDVLDVPLVQEYRRRLLAAMRRLPAAEAARLHEQIDAHLRDALPPDAVDGDVREVLRRLGPPEDLVAASAGDETAGTVRPGPFRRLRRMRRRSLALLAVSLCVAGVLLGWGIDYATSPSLVTGGTFGWWPGQAGGPETTTTIGGLTQSAVPFAFGKTQGFYVALHNPSGWSQTIVGLPPYTPSMANSPLHIRLALFDTDHQDSPTSYRYHELPFTIPPGGYAFLHEYWTTYDCTSAGVTTSTDRAIVRVRVGGLFTRRETIPFAGMAFALVAPPDTPKHQHCPTNVPESIVLGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ9</accession>
    <name>A0A7K0JNZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000033">
        <property type="protein sequence ID" value="MST31299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="440" mass="45943" checksum="5E16BFF0874C2D3B" modified="2021-04-07" version="1">MDEPEQDVLGADEVVVEQAGLFLGQDQDSPGSICETFEQVNRLHRGVSDVGGDPGPVPGGCRHPRAPVSATTWSSVATVYPRLPAREPTPRSRPRRCGFAVGNPARVLSPVVNVLEQLQLPGLDGHLSRVEGALRLAVAAEDPFLHEVAGHLVHAGGKRLRPALAVASALAGGAAVDDDVVQGGVAVELVHLGSLYHDDVIDQAGSRHRVDSVNARWGNLIAILAGDFLLARASEIAARLGTEVAGLLAATIGSLCAGEVAQLQAAFDTARSEAAYVRAVEGKTASLFSASCRIGALVSGLPREWVDALTGYGRALGVAFQIWDDVRDLVGTEDVLGKPAGHDMVEGTYTLPVIRTLARPGVGDDLRALLGRPLDAPTRDKARDLILGTDAIESVTVEGRRWADRADAALGPLRAGGAPLETLDGLAGLGHSLFDNLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP37</accession>
    <name>A0A7K0JP37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baseplate protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000110">
        <property type="protein sequence ID" value="MST31657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="16737" checksum="2DA877CB37EBD66D" modified="2021-04-07" version="1">MDPQPRSRPLPDTSGDPAFIGRGFAFPMRVDAAGRIALTDGAGDLDCSLRVVLATAPGERVMRPTFGCAIWDLVFEPINDNTLGLMAEVVREAIAMWEPRVTVQEVRTIPADDDQHNALVNIEIDYVVRATNDRRNLVYPFYLIPREEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP93</accession>
    <name>A0A7K0JP93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="2">
        <location>
            <begin position="128"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="36380" checksum="2EDA98E4D5B03798" modified="2021-04-07" version="1">MSELLLAANPDPDSSLPFLLRVPLGGGLVFRVKATWPRTNAVFAYPVPSDEWPDDPDIVERIPLRSVARRGAAIDIVAARGREQRSQLVYTKARGRDMVFWQSPRTRKQARPDVTLPTARAAGIAGLQVLVDTREQRPYRFATQQVTTVKAPLACGDYAVAHDGALVAAVERKSLDDLVGSLTSGRLRFALGELATLPRAAVVVEERYSAIFALERIRPAVVADALAELQVRWPSVPIVFCDNRRLAEEWTYRYLAAAHTWARDETRALERIGLTPAPTPAVAAPVIGPTVAEVRAWARDAGYAIPDRGRLRAAIVEAYEAAHGVGAPPSSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB2</accession>
    <name>A0A7K0JPB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CocE/NonD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000141">
        <property type="protein sequence ID" value="MST31812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S15" evidence="1">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="385" mass="42230" checksum="96AD89651ABDE27B" modified="2021-04-07" version="1" fragment="single">MTATSRLVGRLARLRPPEHEDVGVERDLAMTADDGAVLLADRWAPSGVPGAPLVLLRSPYGRRTLDLVGRLLAERGYQVIIQSVRGTFGSGGRWEPFRHERADGAATLRWLAAQPWWPGVVGTFGPSYLGLTQWALAAAAPDGVQAMALSVTSSAFRHAVVYLGGTFTLETGATWMNLLEHQEGGWRRALRAQLRSRRGLGPAYTALPLSTAEAAILGRTIEYYQDWLEHERPGDPWWDEIDFGRDVRRMPPVSMVAGWFDIFLPYQLDDYDALRAAGRPVRLTIGPWTHSSLRLSAAALADGLDWFDRHLGGRDGAAGATIGGGQEGAGPVVGGASRWQRAPRGAARGARPARQAGVRLRLVGRRRWVEIPEWPPPADTVRWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG7</accession>
    <name>A0A7K0JPG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000152">
        <property type="protein sequence ID" value="MST31835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="24116" checksum="417AD0A2FD1436F8" modified="2021-04-07" version="1">MPLEVETKDCTALSDGELAEMADSVTDGPAGFDIGLLSKQAEEWVLVTQVREAGKLQGFSFCTLERIGGTPCLLWGLASVRRNAKRDQVLKALTADQFRRAVLAFPDEDVLIGTRFIDPGAFAAFKGLEEVCPRPGHKPSGEERAWGRRLAKRFGAEGRIDDRSFVVTGDGAAPGVFDFAAAKPEDVEADVAAFFAPLDHARHDVLIAFGWGMAEDLAARYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG8</accession>
    <name>A0A7K0JPG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000149">
        <property type="protein sequence ID" value="MST31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="41"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="538" mass="58705" checksum="7D050E7A525E00AB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH0</accession>
    <name>A0A7K0JPH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000069">
        <property type="protein sequence ID" value="MST31444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="53"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="27559" checksum="120F0F11197E6B60" modified="2021-04-07" version="1" fragment="single">WGLLTRAGAIRTDGRRGTTVAPPRPGPTRYRRALPVSPAFELDLSTGVPDPELLPDLVPSLAQLPRAWHAGSYLDAPVLPDLAEALRADWPYPPPALAVVDGALDGVDLVASALVRYGDRVVVEHPSFPPLLDLLDALGARVVGVPVDDDGLLPDALAAALEARTRAVFLQPRAHNPTGVALTAARAERLAAVVAATEAMVVEDDSAGAISAEAAVSLGSWLPERTVHVRSFSKSHGPDLRVAGVSAPGDLLERVNERRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN3</accession>
    <name>A0A7K0JPN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000088">
        <property type="protein sequence ID" value="MST31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="485" mass="54318" checksum="9857C5ADB1BD2253" modified="2021-04-07" version="1">MSMEDALYPLLPAYRSLPGSAREAVGRAYRGLPETVRFGPRYAGFRRLAAEVEDWSAEQVEAYQLAELRRVLSGAAHSCPFYARSFADAGFRPARLDSLADLAACPTITSRDIVEHLEGMASADDPRRRRLYVSTSGSTGTPVGFYLEKGVSRPKEKAFLAAQWRRAGYDETCRVAVIRGQVVSRNEREPIAYHDPTRDWLVLSAYHLSVARLPEYLEHIRRFRPDVLHAYPSAALQLAGFLQRTGQSWPVPLRCVLAGSERLTDPQRRLLEAVFGCRVYSWYGHSERVVLAGEGRQSRSYYFWPTYGYVEFGPPDATGLREVIGTSFHNRVMPLIRYRTGDYVRVHDPDRDGPREYPWAAASAVEGRVQEFLVTAAGCRVALTSMMIHTHDFDGLYAIQFVQDRPGSAVVRYVPGPRFRDEQLVAIQRVMHQKLGQDFDLTMRAVAEVEKTPRGKGRWLVSSLPQATAAVDVAAPDETSAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ0</accession>
    <name>A0A7K0JPQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000174">
        <property type="protein sequence ID" value="MST31915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="27888" checksum="B1C8D0735F7614CC" modified="2021-04-07" version="1">MSPHVDWGASLDGVDIEGLPDGVEVAIRDSLLSQVPVSVVIPTLNEAENLPHVFARLPAGLHELIVVDGLSTDGTPERARALWPGVRVVNQSRPGKGNALATGFWAATGDIVVMLDADGSTDPREIPRFVAALLTGADVAKGTRFVTGGGSADITTIRRMGNWALTSVVNWLWSVDYSDLCYGYNAFWRRYLPDIVPDCNGFEVETLINIRAAKANLRIVEVPSFEADRVHGVSNLHARRDGMRVLRTIIAERVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU1</accession>
    <name>A0A7K0JPU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000099">
        <property type="protein sequence ID" value="MST31574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="117"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="342" mass="36273" checksum="138CB257A0EF9DFF" modified="2021-04-07" version="1">MGGRGRSRPPTASPAPGGTLAVADPLAASSSVPTGGRASPALVGRPDASRRRLARLGWSFTAPALIVIAAVTIFPIVYSVVMSFSNVSVTGNGYALNGTTLHNYSLVFNYGPWRYALGFTVLYTFVTVAVELVLGTAFALVMERLTRGRGMLMAILLIPWSLITVISAFLWKYMYDSQYGIIVGILRGLGLGSPNILGTQVGGVIALCVADIWKTTPFVAIIVLAGLVMLPQDVYEAAEVDGATRWTTFWKITFPLLRPTIALAVLFRVLQAFGLFDLPYVLTNGGPGHATTSLAILGYFVMFQLGDFGPGAAIATTTALLVVLGCLLFLKVFRAQVGSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW3</accession>
    <name>A0A7K0JPW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000190">
        <property type="protein sequence ID" value="MST31985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="191"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="407" mass="44643" checksum="26CA07E4244755B9" modified="2021-04-07" version="1">MTRPAAGDRLRVLHLIKGFDVGGAERIISLLVQVGDRERFDYAVAHALAGADGLAGPVRAAGVAVHDLGAAGQWDLRWVARLRRLLRDGGFDVLHVHLPYTAGLGRIAAWSLGPGRRPRVVHTQHNMWSRTEWPTRLLSGATWWMDDADLAVAESVKADLPPLLARRTEVVLHGVDRREVSVEAATAVRGELGVKVGEVLVVTVANLRREKAYEVLLEAARRLVDEGLPVRFAAVGHGPLEQEVRALHRRLGLGERFRLLGLRTDVAEILAAADVFTLASHHEGFPLSVMEALGAGVPVVATRVGELPAVVRDGVDGILVPPGDRDALAAALRTVVADEGRRRAMTVAARDGGARFDIRAASQRLEGLYATIGRPPPDRRHGWIWKLRPGERRRRHFRRSAWRYPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ09</accession>
    <name>A0A7K0JQ09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4900 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000187">
        <property type="protein sequence ID" value="MST31977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032601">
        <property type="entry name" value="DUF4900"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16241">
        <property type="entry name" value="DUF4900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="628" mass="65570" checksum="14E4EDB61091B3E6" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ21</accession>
    <name>A0A7K0JQ21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000112">
        <property type="protein sequence ID" value="MST31669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="74"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="32241" checksum="D079B3C7E61860EF" modified="2021-04-07" version="1">MPETRAPGGDRNATALVRLPAPEQPPEQRRGDVDEWGRSERVRDRLRRLYDPVYRLWFRAEWEGLEHIPRTGGALLVANHAGAVPTDAPLLMHGIETELRRPVYGLADSLFRAAPFVGTIWARGGGVAAHPDNAYRLLREQQQLVLVFPEGTKATGKPWSQRYELQRFGRGGFVEIAMRAGVPIVPITIVGGEEAMPTVATFPTLARLLGLPYAPLTLNMLLLGPVGLVTSFPAKFRFRALPPVRFDVAPDQEHYRRGMVYDAAEAIRQQMQESLLDMLRHRRSVWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ94</accession>
    <name>A0A7K0JQ94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoyl synthase</fullName>
            <ecNumber evidence="3">2.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lipA</name>
        <name evidence="9" type="ORF">GHK86_05170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000216">
        <property type="protein sequence ID" value="MST32116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="37"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="30174" checksum="F149B64B8491DCA4" modified="2021-04-07" version="1" fragment="single">VPARMGEEYRSLRKTMRSLSLVTVCEEAGCPNIYECWADGTATFMVNGDRCTRACGFCLVDTRKPLPPDPDEPERVAEAVDRLGLAHAVVTTVARDDLADDGAATLAETVLAIRRRTPATRVELLISDCRGHEPSLERIFAARPDVLNHNVETVPRLQRAVRPSASYARSLAVLARARAAGLTTKSGLIVGMGEETDELLATLADLHGVGVDIVTVGQYLRPTSHHLPVARWWTPAEFAELAAAGEAMGIPHVEASPLTRSSYHARAAAEGVLAPAAGGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB7</accession>
    <name>A0A7K0JQB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system RelE/ParE family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="10097" checksum="B6D3E406793E8E0E" modified="2021-04-07" version="1">MSDRYRLRVAGPAARALAELLPEKVAAAAYEFITEPLLDAPHRVGKPLAPPMAPAWTARRGTYRILYLIDDAHRTIEVTAVRHRSDAYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC3</accession>
    <name>A0A7K0JQC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000211">
        <property type="protein sequence ID" value="MST32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10988" checksum="5CE53A40D9AEF598" modified="2021-04-07" version="1">MQELLALIQSAGHRDFRDARGPMGFTQRQAGGRFTRDEADDYIRRLQEAESDPAEPVEAQGWRHTAQEQLLGRMPAEQLAAELRRRGWMTIEPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE7</accession>
    <name>A0A7K0JQE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF971 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_05445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000231">
        <property type="protein sequence ID" value="MST32170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBBH-like_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="TauD" evidence="8">
        <location>
            <begin position="114"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="360" mass="38907" checksum="79C1544D3A39DCD3" modified="2021-04-07" version="1" fragment="single">MIAVPAVWLRDNCRCAACRDPRSGQKRFRLADLPADVAVERVEWAGEGAARTATVVFAPDGHRSVYPASWLEGPPPPDGDGRRDESTKRLWVAADLPGPPTASWGAYCAGGDVRRRVLEAVQQVGFALLRGTPTAPGTVLEVAGTFGFVRETNYGRLFDVRVEADPTNLAFTGLAIAPHTDNPYRDPVPTLQLLHCLTNAVEGGESGLLDGFRAFADLRASDPDAYGVLRRTPLPFAWTDGHAFLAAERPAVETDPAGRIAAVRWNDRSLGTLRLPVAELGPVYAALRRFARLVAEPSRLLSLRLDAGDCLIMDNTRVLHARTAFAESAAGHRHLQGCYADLDGLDSTVTRLRREAEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS1</accession>
    <name>A0A7K0JQS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000177">
        <property type="protein sequence ID" value="MST31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="11285" checksum="7FA94BE59247EE4D" modified="2021-04-07" version="1">MSAPTAAERLEAAERAASRLEAALRRTGPQDPFPPALAALFAAPFPRFDDLPLDPGARGRLAAVIDRVEAVRNEVAARQRRVAGRLLAVSGALHHQSAAGATIDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS6</accession>
    <name>A0A7K0JQS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000266">
        <property type="protein sequence ID" value="MST32305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="110"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="110"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="24810" checksum="690B766D7C044AE0" modified="2021-04-07" version="1">MVRALDLAGYPWKAVGSPAEPDVVAPDGGWAGAVIAADGDLEGALAACRALRHRELPLSPLLLLVGAGHLPALDPADDLFDDFCVVPFDPPELELRLAHLLRRAGQGGRPELVEYGSLVLNLETYQAAIAGRPLDLTYMEYELLKFLATHPGKVFTREALLSQVWGYEYYGGARTVDVHVRRLRAKLGEEHAALISTVRSVGYRFGQTRWAAGWPGCGGTARAGRSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT9</accession>
    <name>A0A7K0JQT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000184">
        <property type="protein sequence ID" value="MST31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="50"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="41788" checksum="8F404E7CB4FA1970" modified="2021-04-07" version="1">MARTLIRGGTVVDGRGGEPAAADVAFEDGRIVEVGPGLDGDEAVDAAGMTVLPGLFDCHVHVTMDGPDLLRSLGQPFSYQFFRAAANLSATLDCGITTVRDAGGADLGVKTAVDDGLVEGPRMQIAITILSQTGGHNDQWVPSGCSLELVGGGHPGQPSPIVDGPEEMRRKVRELVRAGADVIKVCTSGGVLSPRDDPRHPHFRDDELLVCVTEAAAADRFVMAHAQATDGIKAAIRTGIRSVEHGIFLDDEAIAMMLERGTWLVPTLVAPHAVLEAAAGGARVPPESLRKAEEVVGHHADSFARAVAAGVRIAMGTDSGVGVHGTNLTELELMAKGGMAPLEVWRATTSSAAELMGLGDELGALEPGKRADVVLLAGDPTDLGDLKARIRGVWKDGARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV3</accession>
    <name>A0A7K0JQV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="329"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="555" mass="58936" checksum="0A4EB99DA0812159" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR30</accession>
    <name>A0A7K0JR30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_06605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="348"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="591" mass="62836" checksum="C0BC7175134BEA3B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR83</accession>
    <name>A0A7K0JR83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000213">
        <property type="protein sequence ID" value="MST32104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="421" mass="45197" checksum="D412F146A8FFF670" modified="2021-04-07" version="1">MHDETIALHGGYESDGTRAVAVPVYQTVAHDFTDAAHAGAVFDLEQPGFHYNRINNPTNAVLEHRLAALERGRAALTVASGMAAVSYSVLTVARAGVNLVSTPQLYGATYTYFAHVLPTFGIEVRFAADDRAESIAERIDERTCGVFCESIGNPAGNVVDLQAVAEVAHARGVPLIVDNTVATPLMLKPAEHGADVVVHSLTKFIGGHGTTVGGALVDTGRFAWSEHAGRFPLFVEPEPAFHGVRFAVDFPEAPFAVRARSIALRNTGATLSPFNAFLVLQGLETLAVRLERHEANARAVARWLAGDPRVAWVSYSGFPDHPSHALAERYLAGRAPSIVTFGPKGGYDAAIRFFDGVKLFKRLVNLGDAKSLVAHPASTTHRQLRPEEHAKAGVTPDMIRLSVGLEHIDDLVADLDQALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB9</accession>
    <name>A0A7K0JRB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acsA</name>
        <name evidence="3" type="ORF">GHK86_05290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000220">
        <property type="protein sequence ID" value="MST32139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="42"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="473"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="576" mass="62931" checksum="C3A966BBD8142A61" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC5</accession>
    <name>A0A7K0JRC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15710" checksum="A5E866D8F0C98922" modified="2021-04-07" version="1">MTGNVAQVFVVEEDWRATLAAIRASLRGGGRLVLETRDPARRAWEEWTRAATWTRVQVPGVGEVETWIDLTAVALPLVSFRTSFVFHADGAVLTSDSTLRFRDRAEVTASLTAAGFVIDEVREAPDRPGREMVFVATTGQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ3</accession>
    <name>A0A7K0JRJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4143 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000327">
        <property type="protein sequence ID" value="MST32550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4143" evidence="1">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="10980" checksum="CCAD32279D96992A" modified="2021-04-07" version="1" fragment="single">MAGASPGSPVPRDGTYLGALFESLAVLSVRTLAQRHDARVHHLRTRGGRHEVDMIVEGEDGFVGVEVKLSATVDDRDVAHLRWLRQQLPDQCADLVVLNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS2</accession>
    <name>A0A7K0JRS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_07765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="18665" checksum="920EA057868AEA27" modified="2021-04-07" version="1">GGWSAEPPPPGYAPPPPPGYAPPPGYGYGPPAGFGYGAPPVVYAGWWYRVGATIIDGLIIGVIRTIIDGVSGAGAVTTTNRAAGALAVASLVGLVVTLLYQGLLLAYRGQTVGMMAVGTRIADADTGGGIGVGRGVLRAVVMTVLAILVLPGLLDIFWPLWDRRNQTLHDKAVHTVILRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU7</accession>
    <name>A0A7K0JRU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000353">
        <property type="protein sequence ID" value="MST32660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="19854" checksum="26C5B76F9C45FE96" modified="2021-04-07" version="1">MPGSLEWARPARWSDLRTLRSLWDRADAEIGVGRGGERLVGAIPRPPELDAPPRQGSDEVLPAGGDRLLVVGGIDEVVLGFVAAGIDRSQPAPVALLHVAFVEQEARGVGIGEAMVELVLAWAERSGCAGVDAYALPGSRVAKAFFEDHGFVARLLTMYRRLPVPSPAPAPPPVGGPPPAGGPPPSGGPGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY4</accession>
    <name>A0A7K0JRY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000273">
        <property type="protein sequence ID" value="MST32334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="91" mass="9553" checksum="26A73CD23CD6B19C" modified="2021-04-07" version="1">QRDDRAVVRRFAKPAEDDPAAGTLGGHPVVTATTGAPILAAAAAWLDCELRHALPLGSHTLFVGEVVDCGLPSGDEVTPLRMEDTRMNYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS51</accession>
    <name>A0A7K0JS51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000381">
        <property type="protein sequence ID" value="MST32760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="26233" checksum="7F15DCD8290FA7C5" modified="2021-04-07" version="1" fragment="single">MVDGGLGAREQESLHSAAPGITTVAAVVLTFRRPRLATQVVRGLLEVEGLAPSHVVVVVNGEGGLDDPALEAQVTVVRLPANVGPAGGFRAGMLEALRLPGVRWVYLCEDDVGLFDLPSPRVGALVARVEALEDASVGAVVSYGRDRRGRGGHTLPHRVSGPHGFEEVDAAAWGATLVVRAALDAGVLPDPAYFFGYEDFDFCYQLRAAGYRVLVDREAAGAGRETAAGRAQAFAGQRPNDRDEPWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS71</accession>
    <name>A0A7K0JS71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000391">
        <property type="protein sequence ID" value="MST32796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="6992" checksum="8369C54C0269F57C" modified="2021-04-07" version="1">MRLAPTEIGRRLVATVTERRRATIARLLVSTFPEDAWLFAVSLQKLAAASGEPPSQDWGAVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF8</accession>
    <name>A0A7K0JSF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">GHK86_09080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000415">
        <property type="protein sequence ID" value="MST32870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="20702" checksum="1EC5DC3FBA6CBDF6" modified="2021-04-07" version="1">MPAVSTNDLKNGMSLNLQEGLFSVVEFQHVKPGKGGAFVRTKLKNVRTGAVIERTYRADEKLDQALIDKREMQYLYPDGDSFVFMDTTDYEQINAPRTALGSAADFLKEGDSAVLQMYEGEIVGVDLPAAVELEITETEPGVQGDRVSGARKPATLETGLQIQVPLFVNIGDRVKVDTRSGEYLTRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI0</accession>
    <name>A0A7K0JSI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="14792" checksum="8AEE91720704276B" modified="2021-04-07" version="1">MTAEPTDDEVELAKWDTDVAPDQWARDREWAHPSPEFGPALAEARRQTEAAHAIVTSLAALRRAAGLNQTELAERWGHTQSFVSRVERDPAGVEMATLVGYVEALGGRLTVTVEAGDHIFYEDLVVGRQPSSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ3</accession>
    <name>A0A7K0JSJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FmdB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000423">
        <property type="protein sequence ID" value="MST32893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="11296" checksum="523F682430547147" modified="2021-04-07" version="1">MPTYEYACKSCGEHLEVVQSFKDEALTECPNCHGPLRKVFGNIGIAFKGSGFYKTDSRAASSASKPAEPKSSSGGDAKPAAGESTSSGGGSSASSGSGSSSGSGSGSGSSSAAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM7</accession>
    <name>A0A7K0JSM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_09460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000439">
        <property type="protein sequence ID" value="MST32942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="93"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="32840" checksum="CB0F1ADD8C7C5622" modified="2021-04-07" version="1">MPRLVGPLNENLRLVEEAFAGTRIVNRGNEFIIDGGDATTAARLIDELRLILEQGHSVDPSMVSRTIDMVRADERPSEVLTAEVLRPVRGRAVRPKTSGQKRYAEAIRDNTVTFGIGPAGTGKSYLAVALAVQALQAKSVDRIILTRPAVEAGERLGFLPGDLMAKIDPYLRPLYDALYDMLGTEGARRLLDAGTVEVAPLAYMRGRTLNNSFIILDEAQNTTPEQMKMFLTRIGFGSKVVVTGDDTQIDLPGGRSGLLNLEPVLTGIEGLAWVHLGRRDVVRHRIVADIVSAFEAADASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP5</accession>
    <name>A0A7K0JSP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase subunit CobN</fullName>
            <ecNumber evidence="1">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobN</name>
        <name evidence="1" type="ORF">GHK86_09550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1185" mass="127627" checksum="CBDBB26FAEDFEE80" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW2</accession>
    <name>A0A7K0JSW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_09960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000464">
        <property type="protein sequence ID" value="MST33042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="30688" checksum="FEF4B2F381A9150E" modified="2021-04-07" version="1">MVLASGWKLAVRSFLENKLAVVGLLIVVLMVLFCFVGPVFYHGNIYAANPANSDLAPGGAFPLGTDTNGFDILAQLMHGGQESLEVGFLAAAIATVIGTIWGAVAGLAGGVVDMVMMRIVDVLLAIPFLFIVLILATKFSATVVTLSIVLGIFSWLVPSRLVRGEVLTLRTRDFIAASKVMGATQRRQAFRHLIPNALSVVIVNVTFQVADAILALAFLGFLGFGLTYPHVDWGDMLSNAEQALSDGYWWQVYPVGFCLVIVIMAINFIGDALRDAFDVRLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY7</accession>
    <name>A0A7K0JSY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000462">
        <property type="protein sequence ID" value="MST33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="492" mass="47059" checksum="8A72A927C2D75F79" modified="2021-04-07" version="1" fragment="single">VATPTADGATLTATVPSGATVEGGVYTFWVKAANAVGADVFPVTVELDSAPTFAASATGCPAGSGTPASIDPSAGVTLPVGSPAAEAACVVAFAYPVPAVSETVTGPAGTNALPTGVFFTDLGNGTGELTGTPAAGTPGTYDVTLQAESSSGTTTESFTLTVDQAPQFSGTTTVPVTLGSTGGSANATVDVSASPLPTTLGVGSCPVAGCSVTAGSAVPSTSVADTEAFTVSVSLPAGTGSGDYPVQLSVTAAGVTATETLHIEVTASPGFVSKAVDALLPTGQPDTVDIQTSGGAIGYVCLATTGTGFGLNLPSNPAPGGDPTLASGCAYVDGSGTVALSGTPTVAGHYSTTVYGCTAGAGATSCDAGNAIDTATLDVNIVQPPSFSPAVSAGTLQLAPSGASLATTTGSDATCGKLSSLPADGLTVPLVGEPAESWEPAGTCTTVRVAAVDGQTTAAATDQFDLTYGQDPTTGAAPTTATLTTDAAHPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT05</accession>
    <name>A0A7K0JT05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000476">
        <property type="protein sequence ID" value="MST33086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="22032" checksum="4246A1E8181476C3" modified="2021-04-07" version="1">AGPVLGIAAMAFVWLLGILHRHRVSGNWVLVGPLVAFSALGALSIAYPQLLGNGRDLAQNLFRGELPLATVAVLLALKPLVTLVCWGSGAPGGMFTPVTAYGALLGALLGRLWSMAWPGMPAGAYALVGATALVTTAMSAPVTGVLLMIELTHQLTPLLVPVILAAGGALLVAWALGGGSIYSARAPLPRPDGPSPPRPGTSPPAPSPDGPSPTPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT71</accession>
    <name>A0A7K0JT71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IstB_IS21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000368">
        <property type="protein sequence ID" value="MST32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="2">
        <location>
            <begin position="35"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="14458" checksum="4FDA6B54BAA995CF" modified="2021-04-07" version="1">MTPRNAATTTAGPPPASHPAALAGSATIDRLETLTRRLRLPYLRTTAAEVLPVARSQMWDPAEVLVAVLDAEAAGRDRATITARRRAARFPAGKTFDAWDPDQSTIPAPTQQALRSLEWVTRAENLVVCGPSDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT87</accession>
    <name>A0A7K0JT87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000503">
        <property type="protein sequence ID" value="MST33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="70" mass="7504" checksum="C54E3294AB7BDA4E" modified="2021-04-07" version="1" fragment="single">MSASRPDLEVPEAQASSSREVSPALVRALFGFAPPWVRDFTDLAYEWQRVVAEVVGTFLLVLVAAGAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB4</accession>
    <name>A0A7K0JTB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000505">
        <property type="protein sequence ID" value="MST33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15118" checksum="1EB94BDFC8E7042A" modified="2021-04-07" version="1">VRLAHRLQLTLVIHTREAWDDTFAILGREGVPERTVFHCFTGGPDEARRALGAGAWLSFSGIVTFKGADDVRAAARLCPPDRLLVETDAPYLAPVPHRGRPNRPAWVTVVGAAVAEARGERPGEVEDATWAATAAAFGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE9</accession>
    <name>A0A7K0JTE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000527">
        <property type="protein sequence ID" value="MST33225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005134">
        <property type="entry name" value="UPF0114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03350">
        <property type="entry name" value="UPF0114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="16701" checksum="D710101FAE356911" modified="2021-04-07" version="1">MLRRLQIVILAPFSILLVLSVGSFVYAGYLTVQLAFNTSWSSGGVSDNIVQALQVIDVCLIGTAALVIAAEALVMFMANADASRGVAWLGPDSVDSLKNRALSMVVLILVVTFLEVVVHPQNGRSELELGLAVATVIVSIALYLLASRSNTGGAGRSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI1</accession>
    <name>A0A7K0JTI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="316" mass="32738" checksum="0844E4609107FDE3" modified="2021-04-07" version="1">MGERSVPVATRRRPREGEQGAPRASGAAGGAPPRSERGTPVKPAEIDQLVAEVRQQARARAAARLTEELADRLVEDGRRRLGLDNGTQTAARAVPPPSALGDAGALWVYGLVRPGGPVPAEPGVGGGQVGQVAGEDLAVLCSPLDHGFDAEDADAVAQAAHAHDAVLRAAFASGTVLPLRFGTVLRGADTARLLADAGFAAALAAVEGLGEWRVALHAQTAAGPSPAAGESGTSYLARKATQLRASTPGAVRAVIDERLAAVTVARSGDHVLVDRRKEDEFVSTVDGLRDELEPLWRIEITGPWPAFHFTDLAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK3</accession>
    <name>A0A7K0JTK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000539">
        <property type="protein sequence ID" value="MST33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="10406" checksum="3DC7B3AE6EFBDEB1" modified="2021-04-07" version="1">AGLLAAVPGAVATVGAAPVAPGFAHLCIEGVESEALLVLLDEVGVCASAGSACASGALHASHVLLAMGIAEERALGSLRLTLGPTTTDAEIDVALEAVPAAVARLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV4</accession>
    <name>A0A7K0JTV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000575">
        <property type="protein sequence ID" value="MST33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="456"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="567" mass="61488" checksum="4B3E6680EFBB9D73" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX6</accession>
    <name>A0A7K0JTX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000574">
        <property type="protein sequence ID" value="MST33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021074">
        <property type="entry name" value="Formate_DH_dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11390">
        <property type="entry name" value="FdsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7379" checksum="851E01E5A0068DFB" modified="2021-04-07" version="1" fragment="single">MSDSELPEVRMANQIAANFRHHPDDQAAAEIAGHLRLYWTPWMFERLFAVVDAGGDGVDTLVLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU55</accession>
    <name>A0A7K0JU55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000611">
        <property type="protein sequence ID" value="MST33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13330" checksum="96B9B914BED50E1A" modified="2021-04-07" version="1" fragment="single">MVTRRARSRAALVEEIEDAARAELAEVGAAALSLRSVARRVGLAPSALYRYFDGRDGLLTALIVQAFECLAAAVEGADDPGAPPGERWLAMGRAMRTWAVAHPQDWALVFGSPVPGYAAPATTVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU96</accession>
    <name>A0A7K0JU96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7993" checksum="000515BA7E43FE33" modified="2021-04-07" version="1">MQTHPEHRRQGLAGRLVAAASRTARTRWDVERFVIVADPDGPAINLYRSLGFNDTELQVQLERPPQPPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU99</accession>
    <name>A0A7K0JU99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_12450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000628">
        <property type="protein sequence ID" value="MST33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="339" mass="36052" checksum="47E91D9214B62D10" modified="2021-04-07" version="1">MATLTEIARRAGVSVSVASRVLNGDPNLRTRPETRERVVQAAKDLNYTANYAGRALRLARSKALALIVPDVSTPLFADLLAGAADASGEQDHTLLLGRSDRVTAGGDLVRRLVGEGRVDGFVLQRSDDLSDQALENLVANDARIVLVASRTPRRRGSVVLDDVAGGRLATEHLLALGHRRVALIGGVERSDIARRREQGYTEALHDAGLRKRDAWVTRLGYSPDVAAAAARSLMATSPAPTAIVVANVNGAIGALTALRQGGFDIPGDVSVIAIHDQWMAAHTWPPLTTVKMPFYEVGYLAVRLLLDQLAGAPAEDIVVRDPAPLLILRESTGAPNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE0</accession>
    <name>A0A7K0JUE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="11353" checksum="FDBAA9333800C1EF" modified="2021-04-07" version="1">MAATRREDESMRDVGSDLAKLVLAYAKQETLDPLKALGRFALFGVLGAVFTVLGGFLLSLAFLRALQSEFSSTLSGSLSWVPYVGAIAVASVFVVVALTRMLKTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI4</accession>
    <name>A0A7K0JUI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000662">
        <property type="protein sequence ID" value="MST33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="11030" checksum="8758FA7D5E057CA4" modified="2021-04-07" version="1" fragment="single">MDSTVVNVAFPDIRTAFPHSSLGDVSWVLNAYNVVFAGLLVLSGRLADLFGRKRLFLAGLVLFAATSGLCAAATSVPMLIAFRVAQGAGAALVVPTSLAIVVHASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI6</accession>
    <name>A0A7K0JUI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000663">
        <property type="protein sequence ID" value="MST33612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="12005" checksum="DD606153BBC41BFE" modified="2021-04-07" version="1" fragment="single">MVVDTAHREATAGRTEQGAGGLEIAFVNNMPDGAFIDTERQFLRLLGAHEPDSPVRLRYFTAAARAESPAVGAHVRERYGTLEELVATSPAGVVVTGCEPGAGDVRLEASWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM6</accession>
    <name>A0A7K0JUM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="17446" checksum="34CB5E3D3B3AB1D4" modified="2021-04-07" version="1">MPAITPFLWFDDQAEAAVDFYCSVFPDAEVLHVARYGPAGPGPEGAVMAVRFSLEGAEFTALNGGPSHAGFDETISFVIDCADQAEVDRYWAALTEGGEEIACGWLRDRFGLCWQVVPAGLPEVLGDPVPERAERAMRAMLQMKKLDLDTLRAAADGIPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS9</accession>
    <name>A0A7K0JUS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000694">
        <property type="protein sequence ID" value="MST33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7402" checksum="5109CA7466E563A6" modified="2021-04-07" version="1">MVTRLHRDGVARLAARGAQLLEVLPAAEYDDEHLPGALNIPLKDLGPRTAARLERARPVIVYCWDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV19</accession>
    <name>A0A7K0JV19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16S rRNA (uracil(1498)-N(3))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_13955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000736">
        <property type="protein sequence ID" value="MST33817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="32052" checksum="4950AD0AEE0B61DC" modified="2021-04-07" version="1">MAGGTGPGACRAGSAAVPGRAGATVNAPRPGRAGGVRERSVRAAAAHVYVTDLEAPALGDDDRHHLLRVLRLRPGEPVSAADGEGGWLPCRLTGEGELEPAGPPARAPRPDPLITIALAVPKGDRAEWAVQKLTEVGADRIIPLVADRSVVRWPADRAGRQVERWRAIARAAAMQSRRLWLPQVEAPRTTRQLLAAAASAGGRPALPERAGHQRAQGTPAGGSAEPGGGATGAVAGAGVALAEPGGEAPGLSRPTVVIGPEGGWTEEELEAAPATVALGPSILRTETAAVVAATLLAALRSGLVGQVATPPGAITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV34</accession>
    <name>A0A7K0JV34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000736">
        <property type="protein sequence ID" value="MST33820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="31482" checksum="37F846B22DB12F29" modified="2021-04-07" version="1">MSTTTSPVRRSGTFEFGGMTVHRLGYGAMRLTGRGIWGEPKDRDEARAVLRRALELGVDFIDTADSYGPYISEDLIREALHPYPEELVIATKAGLTRTGPDEWHPVGRPEYLRQECEMSLRRLGVERIDLFQLHRIDPKVPAEEQFGLLRDLLDEGKVRAVGLSEVSVEEIEAARRVVPVVTVQNLYNLANRQSEEVLDFCEQQGIGFIPWFPIAAGDLARPGGPVDDVVKESGATPSQVALAWLLARSPVMLPIPGTSSVGHLEENCAAAEVQLTPEQVSALTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV69</accession>
    <name>A0A7K0JV69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000750">
        <property type="protein sequence ID" value="MST33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="361" mass="36631" checksum="77CC2FA12E1C30A0" modified="2021-04-07" version="1">MAAALTLLVFLVLILSALADGLYYGATGALRAGRADLYTFSADSRRQFARSSLPAGDAGTIASVPGVAAVGPVGTLQATGRCSGRCPGNLIDLALFGYLPGHPGGPDRAVEGRLPGAAEDGVAAADISLRDDGVRIGDRVTVAGTTVTLRIVGFTSDSRYLLQPTLWTTIATWRKVQSQARPELAGAGDTVQAFAERLRAGASPATVAAAVDAALGNRTATVGRRTAVLSLPGVKEQRSTLDQIVYATLAVAGIVTALFFALITLEKRTQLAVLKAIGASNRYLGAGVVVQSLILCALGTALGLLFTRLAALLVPAAVPLSFTAASAATAAVGTFVMGLLGAAFSFRGLARIDPATALGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA7</accession>
    <name>A0A7K0JVA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000759">
        <property type="protein sequence ID" value="MST33878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17471" checksum="9C0969941C438277" modified="2021-04-07" version="1">MVPESRTFAADPASVAEARRFVRQTLAGWQAEHFEDRAVHVLSELATNSVIHARSSFVVELSLDPAGLRLCVSDDSGRRPVRKSRSAQATTGRGLALVEALSAAWGVDRNGDGKTVWVLLTAQPDEGREPTGRSTPLALFAPPEDVDADPDEGIRACLTRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI8</accession>
    <name>A0A7K0JVI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing)</fullName>
            <ecNumber evidence="7">3.7.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iolD</name>
        <name evidence="7" type="ORF">GHK86_12465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.22" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000629">
        <property type="protein sequence ID" value="MST33529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102481">
        <property type="term" value="F:3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="223"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="420"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="625" mass="66562" checksum="411E6298BC40D235" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP9</accession>
    <name>A0A7K0JVP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argF</name>
        <name evidence="5" type="ORF">GHK86_15035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000819">
        <property type="protein sequence ID" value="MST34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="143"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="300" mass="31550" checksum="1D348598CC851F7D" modified="2021-04-07" version="1">MMRHLLDIDDLAPAELATVLDLAECPAPRPVLAGRGAALIFEKPSNRTRNASEMAVVALGGHPIAIRGEEIGLGVRETPEDVVRVLGRYHAVVGARVDDHRVLEAMAATDAVPVVNLLSDLAHPSQAIADLLTLRQRWGTLAGHSLAWVGDGNNVARSLVLAAAMAGIEVRLASPPGYRLDPVVVDAARALGGTVVEADRPADAVAGADAVATDVWVSMGQEDQSSARIDAFAGYRVDAAMMREAAAGAVFLHCLPAHRGLEVDGEVIDGPASLVWEQAGNRMHALRGLFSWLLGERACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ5</accession>
    <name>A0A7K0JVQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000668">
        <property type="protein sequence ID" value="MST33634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="17971" checksum="E205BF121C10910F" modified="2021-04-07" version="1">MPRYAIDDREPTIDPEAWVHPDAVIIGDVTIGPRSSVWPCAVLRGDYGSIVIGAETSVQDGAVIHATEELATIVGSRVVIGHLAHLEGCRVEDASLIGVGSVVLHRAVVGRGATVGAGAVVTNDLVVPPGALAVGVPAQVKEGRSNPAMIEQSAAIYVDNTARFRRGLRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR6</accession>
    <name>A0A7K0JVR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000823">
        <property type="protein sequence ID" value="MST34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005134">
        <property type="entry name" value="UPF0114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03350">
        <property type="entry name" value="UPF0114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="23479" checksum="CCB8A067929B1F46" modified="2021-04-07" version="1">MSGKGSSHARRSAGRRPHVAGSRPVAATAASSGHPARPVRAPVTDASPDGPEPPGDRHRLEDAFERVLAATPKLVIVPVVILLLAGVGAFVYDADVLVESIREVIRHPVPVGNKIGLFLLIVDLALIGATLIIAAIGLYELFISRVDTGGHRRLPAWLEVRDLNDLKARVIAMIVLVAAVSFVEVVVDLGSGLEILEVGGGIALVIGALTLFVRFGSQGSGGSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT1</accession>
    <name>A0A7K0JVT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_15125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000823">
        <property type="protein sequence ID" value="MST34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="26265" checksum="57A1D0E45B8AA358" modified="2021-04-07" version="1">YGYGRAEDLAGVFVVLVVAASAVVAAYEAVGRLLHPTPVDHLPWVAVAGLVGFAGNEIVARYRLRTGRRIGSAALEADGYHARTDGFTSLAVVASAIGLAAGWRTADAVFSLLITVSILVVVRSSARDIYRRLMDAVDPDLVARAESVLAGTPGVQRVETVRLRWVGHALHAETDLVADTTLTLGAAHDIAEHARHRLLHQVRRLDSVTVHMNPCGHDGTDPHAVTAHHAQAPALTGQTPTDQRSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT4</accession>
    <name>A0A7K0JVT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000680">
        <property type="protein sequence ID" value="MST33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="26820" checksum="794CED522B39072B" modified="2021-04-07" version="1">MSGLNALAIDDEAPALDELGFLLRHCPLVDRVEGASSAEDALRHLQREAFDVVVADIRMPGLDGLELARVLRHFAAPPEVVFVTAHEGYALEAFEVGAAGYLLKPLDAGRLAEVLTRVRAARSGGTAPDDLATLAVELPGRIRMVARNDVEWVEASGDYVRLHTVDGDSALVRIPIGLLEERWSEHGFARIHRGHLVALGAVRELRTDGTATYARVGTRDLPVSRRHVHDLRERLVRHAGHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW63</accession>
    <name>A0A7K0JW63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000884">
        <property type="protein sequence ID" value="MST34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="65" mass="7035" checksum="E468178956C677BD" modified="2021-04-07" version="1">MTCDGRGLCAELLPERVRLDDWGYPIIDPRPLPPALLGPARQAIAACPMLALRLRAVTEGPAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW93</accession>
    <name>A0A7K0JW93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GHK86_16035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000903">
        <property type="protein sequence ID" value="MST34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="11213" checksum="22BFC6152CE2BBF0" modified="2021-04-07" version="1">MAWRQATWDGTHWREDAACRDVDAGLFFPTGSGPEALEQTAHAKLVCSDCPVAQECLIFAVTTNQEYGIWGGLDEEERREVRRQWRRASRRRVQHAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC7</accession>
    <name>A0A7K0JWC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF2156 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_16155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000914">
        <property type="protein sequence ID" value="MST34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="391" mass="41975" checksum="24EB5336985011E2" modified="2021-04-07" version="1" fragment="single">RRRRGSTAGEEAAAALARARAVVARHGSGTLDYFALRPDKEFFFWGDTVVAYAVYRGVCLVSPDPIGPPTEREPAWRAFRRFADEHGWAVGGLGAGEEWLPVYRATGMHTLYVGDEGVVRTDRFSLEGGRFKGLRQAVNRVAKYGYTISFHDPAHLDPALRAGLQSVMTKSRRGDVERGFSMTLGRVFDPADTGLLLAVVHAPSGEPVAFCQYVPAPGIGGYSLDLMRRDDGEHPNGLVDFAVVETIRHLAAEGRTGLGLNFATMRAVIAGESGEGPWQRAQAWLLRRMGDSMQIESLWRFNAKFDPEWLPRYAIYDAPENAVAVAMAVAQAESFWELPVIGRFLVPRGDREPATAAPIAGGGDPGPGEVGVEPAPATGPSAAGASGAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC9</accession>
    <name>A0A7K0JWC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COX1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_16200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000917">
        <property type="protein sequence ID" value="MST34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="8">
        <location>
            <begin position="105"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="646" mass="71593" checksum="7D40DE95DCD5E14E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY6</accession>
    <name>A0A7K0JWY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001009">
        <property type="protein sequence ID" value="MST34446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="490"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="709" mass="78427" checksum="3071DF89D939FF3E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX75</accession>
    <name>A0A7K0JX75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001067">
        <property type="protein sequence ID" value="MST34551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029812264" evidence="3">
        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="31706" checksum="DC7A826C3E681B0A" modified="2021-04-07" version="1">MALALTLIFSLLTAVTNAASATIQWDAAKKAPPEEAKGFRLALYLARRPEYLAAIGALTLSFLFQAAALHEGELAVVQPLLVTELPFTLFLSAAWLGLGLDRRELLGAAAICVGLGVLLGVGQPHGGRLTVPPETWAVTGAAVAAALIGLVLGARRGGSLRRTTLFALASGIGYSVTAVLVKATTDRASGGIVHLLTGWEPYAMIIAGMLSVLLQQQALRAGALAVAKPVTTIVNPVVSVVLAIVVFDESLRGGGLVAVEVLAMLVLVGGILELSRSPLVTGQRRDDQRHEGRLGGGRRHGADRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA7</accession>
    <name>A0A7K0JXA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001079">
        <property type="protein sequence ID" value="MST34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="17555" checksum="3293FA57E951E7E9" modified="2021-04-07" version="1">MALFGDERRFGWGSPERSRWYRWFADPGERRLHAPVDHERLSRSYAAALRVATGRHPDDRRAQQLVDRLAAVSTEFTALWTDHDVSWRPGTEAKHFIHPEVGPLELDCDTLVADSDSQILLIYTATPGSESADRLRLLGVLGDQHFVVPALARPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB1</accession>
    <name>A0A7K0JXB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001087">
        <property type="protein sequence ID" value="MST34591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="46"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="553" mass="59785" checksum="105DEE47E1788788" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD1</accession>
    <name>A0A7K0JXD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PglZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001101">
        <property type="protein sequence ID" value="MST34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="6663" checksum="0B88E85E6507DC38" modified="2021-04-07" version="1" fragment="single">MAPVPPPTLPDYGGACLSSLVPALLAPPGERPGWLPAPVAAARQVVLLVLDGLGWRQLAERRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ8</accession>
    <name>A0A7K0JXJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001099">
        <property type="protein sequence ID" value="MST34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="446" mass="47154" checksum="12D7CB588274868E" modified="2021-04-07" version="1" fragment="single">MQYAPAVGIDWGADGGQRRADGEGATDLDAWQAFGANAAAARDRLALALSVGGLGLWTWDRETRRIAWDARLLAAFGRSLATAPATIEAWLELVHPDDRPDVAALLAEAARGPEPARMEFRLVRADGQVRWLECSGRALFEHGELIGAIGVMADVTERHETEARTQNLLRLVQLNADLSMTLSASLDPDVILQRLADRLVPDLADVCVVDLREGLGSRSQVAVAARQPELRGVMEEAERRLPRRHNPASALARTLASGVPTLVADSARGYISSVVPDAAVAGLYQQLGMRSLLVAPLVARGEVLGAISLVRTVPPGGTAHERGPGGTAHERGLYGPDDVDVAMEIGRRAGLAVDNARLYAGERAIAEALQRALLPAIEAPPGVAVAARYLPASASVGGDWYDLFELPDGGTSITIGDVVGHDLRAAASMGQLRSVIRSYASEGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK7</accession>
    <name>A0A7K0JXK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_18405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001150">
        <property type="protein sequence ID" value="MST34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="23354" checksum="DAC86236C7BBF644" modified="2021-04-07" version="1" fragment="single">MASSRITDSVGRVLGQRYRLTRPIGSGASAHVYVAEDVVLRRRVAVKVLHPGLAGDEAFLRRFRAEARVVAPLRHPHILRIYDWGEDEGDPYLVSELLEGGSLRSLLDQGALLTPTQAATVGYEAASALDHAHRRGLVHRDVKPANLLFDDEGRVSVADFGLARALAEATWTEPAGAMVGTARYAAPEQVQGQPLGDRSDVYALALVLTEATTGSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK8</accession>
    <name>A0A7K0JXK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001108">
        <property type="protein sequence ID" value="MST34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6158" checksum="A51BC264A1791A79" modified="2021-04-07" version="1" fragment="single">MASPAPARSAIGRRLTLLLAVACGVSVANLYYAQPLLSTVAAGLGTGPGTAGLVVTLSQVGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT0</accession>
    <name>A0A7K0JXT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001201">
        <property type="protein sequence ID" value="MST34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="26071" checksum="6E9754607F3546C4" modified="2021-04-07" version="1">MPERPVAVVTGASSGIGAASARALAAGGWHVVLGARRVERLESLAAELGPEAATALPLDVTRPASVEDFARQVPSCRLVVHAAGGALGLDPVADADEDRWRTMYDTNVLGVLRVTRALLPALLDSGDGQVVLISSVAAFEPYAGGAGYNAAKAAASSLADVLRIEHVGQPLRVSEIAPGMVETEFSLVRFDGDAERAAATYEGMTPLTAEDVAEVVAFVASRPPHVDLDRIVLRPRDQARVWLVHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY57</accession>
    <name>A0A7K0JY57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001019">
        <property type="protein sequence ID" value="MST34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="69" mass="6933" checksum="B1DD4DB494B7C22D" modified="2021-04-07" version="1" fragment="single">MGAAVVGLACCVALLALLVAGLTRRVVRAERLVDELATMARPGTSRPERAPLVGAEAPPVRGVDAAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG1</accession>
    <name>A0A7K0JYG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001342">
        <property type="protein sequence ID" value="MST34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="16260" checksum="1290530CDF5D57ED" modified="2021-04-07" version="1">MAAAARAAHDLHEAGWAHGDIRGGTILLDAGQGLLDLPLATATDLPPTVARVGAAEELDGVEPDRLWGAGPTRASDVYALGAVLHRHLTRGLLHPDLPGDPVVTAVQRVLVERPRVDTELHGPAADLVRACLDPDPGRRPSSALAVAERLEELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK1</accession>
    <name>A0A7K0JYK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_18060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001105">
        <property type="protein sequence ID" value="MST34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="294" mass="32225" checksum="96E263635080FACC" modified="2021-04-07" version="1" fragment="single">MLPSAAPLAAAMPMGREPVVDLHNVLLAWTWSPFTIGVDVAIVAVAAWYLRAVDRLDARHRTWSPWRTLSFLAGLATVWLALCSSVATYTGYTFVAHILQHLLLMVVAPPLGALGAPMTLLLQTSNRRFKTAVLKALHSRVFAVVRHPVPVFFMYYLSMYAFFLSPALGYAMAHMWLMDLINLGFLFGATLFWWPMVGIDPIPGGRINPGLKLLNLSLGVPVEAFLGIAMMMKRAPLAPIYSLASSHHGGALLWGASEMATVLAGIPIFVEWVRSDERAARRIDARLDAGLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP6</accession>
    <name>A0A7K0JYP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001415">
        <property type="protein sequence ID" value="MST35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="295" mass="31343" checksum="03145D61C68ADACF" modified="2021-04-07" version="1">MGRRPEQRHRAGGRLGVLQGVHRDPIGHGADSPRSGRLVRRAGGETELTEQRAVDGLHLEVDGGVVVATIDRGEANLVSMEMCGALTDLLFDPPAGTRVLHLRAAPPVFCLGRDRGATDEDGLRVEAETLVALNRALREGRLLTVAEVGGDAAGYGVGLAALCDLSFTAPSARFWFPEVDAGLAPTVVLAWLPSLVSRTHAFRLTATGARVDGREAARLGLVTAVAERDEDLSALVTAEIGRLLSRSEHAQSEIRSFLRDSAGADAETVDRLAVDRLVANSLFLRRVAGGELADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ4</accession>
    <name>A0A7K0JYQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001361">
        <property type="protein sequence ID" value="MST35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="130"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="573" mass="61526" checksum="107C596E47526F21" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ7</accession>
    <name>A0A7K0JYQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001143">
        <property type="protein sequence ID" value="MST34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="21789" checksum="A780EC3A4CC72913" modified="2021-04-07" version="1">QYGYAAVFVLVGAESLGVPLPGETILIAAAIYAGSTHRLSVWLIFAVAAAAAILGDNIGFWIGDRGGYRLLHRYGRYIRVKDKEIKVGRLVFDRHGGKVVFFGRFVSLLRTYAAFLAGTLKMRWRRFLPYNAAGGIVWAALYSFVPYAVGNAIKHTSHTIAIVLGIAAVVVIVAAIFLVRRKAAQLEAAAEAAYPGPLPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV9</accession>
    <name>A0A7K0JYV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001466">
        <property type="protein sequence ID" value="MST35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="12536" checksum="15EAD479156DC428" modified="2021-04-07" version="1">MTGGADPGPSRSGVVVHLDDPEPAKHAGVVTNVANLLADLDDGSPVELVVHGPAYTAVLRDAPEAGRIGDLLARGVIVAVCANTLRGTGTSEDQLLPGVTVVPAGVGELVRRQREGWAYLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX3</accession>
    <name>A0A7K0JYX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2236 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001190">
        <property type="protein sequence ID" value="MST34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="33161" checksum="4ACBE41821D69DCC" modified="2021-04-07" version="1" fragment="single">MSGTRPSHAGGCGERPGPGPGSLSWSLVGDARGLLLAPATIVLQLAHPTVGAGMAQHSDFTRHPWGRLLRTINSSIRSTYGSERVAAGEAARLREMHAGITGVDDRGRRYAALDPAASAWVHLTLSRYFIDVQSLLGRRLPDSDAERFYREWRTVGLGLGVPDAAMPADWGAFGRYFDTVVSDVLEDNQAVRHALALTRRPPPPARWLAGPLWDRLTDRPAALHELFTVGALPGQLRERLGLAWSEAEERKLQRWATGIRRAGEALPAPLHYYPQVAPHVLAAALYGRRPGGPLRRRPPVARCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ36</accession>
    <name>A0A7K0JZ36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001233">
        <property type="protein sequence ID" value="MST34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="412"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="502" mass="52799" checksum="1A7CF83DFB623007" modified="2021-04-07" version="1">MTETIAALVARAAQGGSLATVEGEEVRGGDLGAAVERFAGALRSLGLGPGDRVGIVLPNGPEMALALLASMVVGSAAPLNPKYREEEFRFYLEDLRPAAVIVGADDAGPSDVVAAAVPAGVPLVRVAGQGFAAELTTGDGQAGGGQRSGRAPSGADEALVLHTSGTTSRPKIVPLRQRNLYSSARNIAASLRLTEADRSLAVMPLFHIHGIMASLLAPLSAGGSAVVTPGFDAFGFHRWLAESAATYYTAVPTMHQMVLARAPKDRPHALRLIRSSSARLPAAVREGLEERFAVPVIEAYGMTEASHQIACSPLPPGPHKPGSVGVATGVDVAILDREGRQLPAGERGEISIKGPTVITAYENNPSANEAAFTDGWFRTGDEGVLDEDGYLFITGRLKEQINKGGEKISPLEVDEVLLRHPQVAEAVTFAIPHDKLGEEVGAAVVLAPGEELSDVELRRFLSERLAAFKVPRTIVFVDEVPKGATGKLQRIGLWERLQADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ89</accession>
    <name>A0A7K0JZ89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <ecNumber evidence="4">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_21075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001521">
        <property type="protein sequence ID" value="MST35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="91" mass="9068" checksum="9CE4D5AE6C7C03E0" modified="2021-04-07" version="1" fragment="single">RVGQGFDVHPFSDDPHRRLVLGGVELPGPGLDGHSDADVVAHAVADALLGAAGLGDLGTRFPASDPALAGADSMVLLAQVVAAVRAGHEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH2</accession>
    <name>A0A7K0JZH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="2">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tilS</name>
        <name evidence="8" type="ORF">GHK86_21495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001591">
        <property type="protein sequence ID" value="MST35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="25317" checksum="0E0A6C86E6F9B40D" modified="2021-04-07" version="1" fragment="single">PPVTDLDGLAERCRWPVRPGGTATAAVSGGADSLALLVLARRAGLDVLAVHVDHGLRPGSAAEADHVAAAARRLGARFEARRVSVTPGPNLESRARAARYAVLPPGVMVGHTADDRAETLLLNLLRGAGLDGLSPMRPSPRLSRPLLALRRRETVAVCAAAGLEPLHDPSNDDLAFRRNAVRHRLLPLLAEVAGRDPVPVLCRQADLLGDDADLLEGWAAGLDPTDARALRAAPRALARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH6</accession>
    <name>A0A7K0JZH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-2-hydroxyglutarate oxidase</fullName>
            <ecNumber evidence="2">1.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lhgO</name>
        <name evidence="2" type="ORF">GHK86_21915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001682">
        <property type="protein sequence ID" value="MST35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="295" mass="31519" checksum="F6784445BF228A9F" modified="2021-04-07" version="1">VPGLRRVSPAEMREIEPHVAGVAALHSPATAIIDYVAVAEALAGEVVAADGDLRLGWPVQSVARRGREIVVGSPEDELVVDQLVVCAGLQTDRVARLAGDDGYPTIVPFRGEYHRLRTEREHLVRALVYPVPDPAYPFLGVHFTRRVGGGVDVGPNAVLALAREGYRRRTVDLRDLLATATDPGFWRLARRHWRTGMEEMCTSLSVAAFVGRARRYVPELQPADVVRAPAGVRAQAVGRDGALVDDFVLGGDGAVVTVRNAPSPAATSSLAIAEEIVRRLPPPAAAGGRAGPAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZL7</accession>
    <name>A0A7K0JZL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001622">
        <property type="protein sequence ID" value="MST35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="1">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="30641" checksum="9ED6D6BB0CAE082B" modified="2021-04-07" version="1" fragment="single">HPAAALAGDTPVLDGGAAVLAGDTPVLDGGAGVLAGDTPVLDGGARGAGVLAETRRGLASEADALAEASRCLQCPDPTCVRGCPAHNDIPAFIAALREHDLRRAQRVIRQTSFLPDVCSRVCDQAVQCEGACTWSLAGGTPVAIGALERYVSEAAAMLPLEAEDDLGAGTTVAVVGSGPAGIGAAFELVRAGASVTVLEARDRPGGLLDWGIPGFTLPADVARRPWDDLLLAGVDLRCGVEVTPADLEDLLATFDAVILAHGAGVPLRLPVAGADLDGVCDATEFLLDAQGALEGGSPSRLVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZL8</accession>
    <name>A0A7K0JZL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001638">
        <property type="protein sequence ID" value="MST35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029476187" evidence="2">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="50" mass="5279" checksum="383AD8828EE0C2D9" modified="2021-04-07" version="1" fragment="single">MHLVLLTTLFAAVAGKASTPAKASAGGSSFFLIVLLALAVLYFFVLRPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0I1</accession>
    <name>A0A7K0K0I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001577">
        <property type="protein sequence ID" value="MST35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8067" checksum="53E365CED258E8B9" modified="2021-04-07" version="1" fragment="single">MPLPQPHPDLAGLDLLVSVGELGSITAAAEAHGVTQPAASMRLRSLERVLQVELLERSRTGARLTAAGAATAEWAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU7</accession>
    <name>A0A7K0JMU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GHK86_00880</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="WJHE01000031">
        <property type="protein sequence ID" value="MST31286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="39"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MST31286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="707" mass="77831" checksum="84B2531210CFF694" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV7</accession>
    <name>A0A7K0JMV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="26403" checksum="002A0D951C143884" modified="2021-04-07" version="1">MSTNRTRVPQAERLKPGRGRRPAGEVRRAALGAAGELLLAEGLSGVTFAKVAALSGASKMTLYKWWPSPGVLAYEAYGEALEVPLAFPDTGNVRQDIAEQMRAFVRHLRRNGKVVAELIGAAQSDPDLAKALSAHYVKRRRHLAVDRLGLAQRRGEIRPDVDLEAVVDQLWGACYHRLLLPALPVTTKFVDELIDNVFAGIRVTSGGENSDLPAPPVRVRDPGGGLVEQRNGSSGDSSPRHGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX7</accession>
    <name>A0A7K0JMX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000021">
        <property type="protein sequence ID" value="MST31227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="27124" checksum="2A6F1D6B96599432" modified="2021-04-07" version="1">MSARGRPGTGARDPAPDVSSGTADGGGAIRVLIVDDQALFRRGLHVVLGTEEHIDVVGEADNGEEAVALAERLAPDVVLMDVRMPRLGGIDAARRIRELAPATRILMLTVSDEEEDLYEAIKAGANGYLLKEISVEEVAEAVRAAVQGQSLISPSMASKLLKEFNSLARRAAEQEQAPTPVLTARELEVLRLVARGMSNREVAAALFISDNTVKNHVRNILEKLHLHSRMEAVMYAVRRRLLDPHHPEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN28</accession>
    <name>A0A7K0JN28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_01290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000047">
        <property type="protein sequence ID" value="MST31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="213"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="340" mass="36387" checksum="63187FA2795DB9D9" modified="2021-04-07" version="1">MSGSLLQRAQAGDQQAFADLTAPHRRELHRHCYRLLGSITDADDLLQETLVAAWRGLPGFAGRSTLRVWLYRIATNRCLNAIRDGKRRPPTVPVPPFEPPPPSRHDAVTWLQPYPDAWLDDPATAPPARVETRETVGLAFVAALQLLPPRQTAALVLGDVLGFPVADGADMLGVTPTAVKGLRQRARHAIRQRGAVAEGRVAAGVHGAQAELVRRFADAFAADDVDAVVDLLTDDAWLRMPPAPHEYRGRPDIAAFLLASAAGRAGRRLTLRPTRANGQPAFTCFLPTSRGAALEPSGVVVLDVVGDAIAGVTRFLDPRLPELFDCPVGGAAGPLAPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN40</accession>
    <name>A0A7K0JN40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000046">
        <property type="protein sequence ID" value="MST31365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="349"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="443" mass="46617" checksum="FEA455A0B524F564" modified="2021-04-07" version="1" fragment="single">MTTERHTRLVVIGGGPGGHSAASTAARLGADVTLIEKDVYGGAAHLWDCIPSKTMIATGGALTFAQRITGMGLEQLDAHLDQSAQRRRVDRIEGYLNGQVVQLLESQGVRMLKGVGRLKGPHEVVAETATGVEEIDADAVVIATGTRPRIPSWAEPDGDRILTTRQAYPPPSIPEHLVVIGSGVTGVEFVHMFSAFGAKVTLIVSRQQVLPNKDPEVAAALEDNLLRRGVRLFKGARAEMIQRTDDGGVAVACDDGRAALGSHALFCIGSIPNSDGLGLESAGVDLDRGGYVVVNQHCQSNVPHIYAAGDVSGKLPLSSVASMQGRKIAEHAMGLHTREHQHIDYDKAASAIFTEPEIADVGLAETEAFASGRKIRVTKVPYQSTAKALINDDPGGFVKIVSDPATGVVLGGSIVGRHAAELISVIALAVTAHLKVSDIVESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN77</accession>
    <name>A0A7K0JN77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000064">
        <property type="protein sequence ID" value="MST31422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="20429" checksum="7C19411DE4F76905" modified="2021-04-07" version="1">MARWKPNARERLTQAALDLFAERGYEDTTVIDIAQRAGLGKTTFFRHFQDKREVLFGDGTLDALLGRMIAAAPPDATPLDAMAGALDALGQRSFTAARRGFLARRQAVIAANPELQEREALKNLGLTASIAKALMERGVPEVTARVTAELGALASRIAYERWSASTGDEDFGTALRLALDEVQAVSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU8</accession>
    <name>A0A7K0JNU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000097">
        <property type="protein sequence ID" value="MST31567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17590" checksum="AB533CAFA2DF819D" modified="2021-04-07" version="1" fragment="single">MTTLNLWQDPFADVEQLVRTVFGSQPDRPQGWTPASEVFRDGDDALVQVEVPGLDPARDVTVEIERGHLVIRGERRQQSQTSTRRATVGERRYGSFRRVFRLPDHVGPEALTATYDAGILTVRVAGAYAPPAPVKVAISTGGPAPVDTTAGAPSSEPVERATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP92</accession>
    <name>A0A7K0JP92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000138">
        <property type="protein sequence ID" value="MST31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="27925" checksum="C066DD379F8CDD6A" modified="2021-04-07" version="1">MAPCSASRFLSPRRYPRSRRLPSILIIDDDPDLLGVCRVGLEAFGYDLHTAETGNDGLTQTAIRAPDVVVLDLGLPDLDGVEVCRRIRQWSRAPIIVLSADGSEDRKVEAFDRGADDYMTKPFGMRELNARLRVALRHRTVGADDDQPTEITVGPLHLDLVHHEATLEGQPLDLTPKEFDFLAYLAHNVGKVCTRRLILEHVWGPGYAKEQQYLKVYAYRLRRKLKDERGRLLQSDPSVGYRLVAPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD2</accession>
    <name>A0A7K0JPD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine cleavage system protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="16704" checksum="4CB50FC549C79AFC" modified="2021-04-07" version="1">MPTPTWAGCAVPADLLYDVGHDVWVRVEHDEVTVGMTDVAQTRCGRLVAISWKAAGRRVRRGRPLCVIESSKWVGPVLSPLTGTIAATNELRFAEDIAIANRDPYGEGWLVRLRPEDLAGEAAHLAGGEEAYEQYRRVIDEQGIRCFRCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK6</accession>
    <name>A0A7K0JPK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="5" type="ORF">GHK86_04035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000168">
        <property type="protein sequence ID" value="MST31896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="8399" checksum="D0AA98DCF109277F" modified="2021-04-07" version="1">MPNKKEDAIVLEGTVSEALKNATFKVELANGHEVLAHNSGKMRMNRIRVLPGDKVQVEISPYDLTRGRITYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ1</accession>
    <name>A0A7K0JPQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar filament capping protein FliD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fliD</name>
        <name evidence="2" type="ORF">GHK86_04240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000177">
        <property type="protein sequence ID" value="MST31936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliD_C" evidence="1">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="294" mass="28055" checksum="269A5AC599AC1F02" modified="2021-04-07" version="1">AAYAANPSTVAATFTQGGSSTQPGISVYQGSDATQSGSYAVDITQAATQASVTGAVVTSGAISGPETITLSASGGTASYAATSGETLTAIAAGINAATAAAGVGVEASVANGALTLTSTAFGSGGDFQVSSTAAGSGSTGLVSTANTPVSATGLDVAGTIDGKAASGTGQLLIGALDSPAQGLLLQVTASAAQVGSGGLSSTVSYSPGIAAALANAAYNAVNPVSGTIVSATNGLQTQANDLQTQIANWNPILSQKEQTLQQEYTAMETSLAALDNTKSQLGQSFSSSSTPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV8</accession>
    <name>A0A7K0JPV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000190">
        <property type="protein sequence ID" value="MST31986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029446749" evidence="1">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="207" mass="20661" checksum="D62D300D452DA8F9" modified="2021-04-07" version="1">MLTAGAVATGAVWAAPAIESFTSVAAAQSGPAKPHHGTGVSYVTVLLGEGNGDVATVYRLKATLTTQPSAGTPTVAASLEPGFTATDGGCFTGSSPFRVPGSDPTTAVPSSIIQQSGLPSGVAGSFVYQAGQQVFQLTNSSSTPYTLAAWVVHQGQCCAVGEPNLVHPGATTYPGPTSSSGSADPFLLAPNGGTITFPWPSNNMDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ65</accession>
    <name>A0A7K0JQ65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">recA</name>
        <name evidence="13" type="ORF">GHK86_03065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000121">
        <property type="protein sequence ID" value="MST31709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="11">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="12">
        <location>
            <begin position="189"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST31709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="36733" checksum="398A933AF20422D4" modified="2021-04-07" version="1">MALGQIEKQFGKGAIMRMGESTHMQVESISTGALSLDIALGIGGLPRGRIVEIFGPESSGKSTLAMHVVAEAQRNGGICAYIDAEHAMDPVYAKAIGVNVDDLLISQPDTGEQALEIADMLIRSGALDVLVVDSVAALTPRAEIEGEMGDTHVGLQARLMSQALRKLTGTLNKSNTIAIFINQLREKIGVMFGSPETTPGGRALKFYSSVRLDIRRIESIKDGAEVTGNRTRVKVVKNKVSPPFKQAEFDIMYGRGISREGSLLDVAVELGIVKKSGAWYTYEGEQLGQGRENAKTFLAENLEVLLEIDQAVRQQSGVGQLDGEGGVPLGADPLDDEPISLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ99</accession>
    <name>A0A7K0JQ99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_05200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="19654" checksum="A01709E702280D77" modified="2021-04-07" version="1">MDRAVARGADSLTGGSASPDEEMLSQALAAVRPALRRYLRRRVPTSEVEDLLQVVSLEMWRSWFRFRPGGNLEAWAFGIAHHRSADWWRNWGRQPALGVAADLTDPDLEPGEAVAVSVTARAALAALPDGPRTAVTLAYFGGYTQPEIASQMGLPLGTVKSWVTRSLRHMAASLLDADTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA0</accession>
    <name>A0A7K0JQA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000211">
        <property type="protein sequence ID" value="MST32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="26134" checksum="51F32912493B2CFE" modified="2021-04-07" version="1">MTTHSGGRASVAPFGIRVRGSGTAPGATMAHPSGGAPAAGLTSGHGPLPRQSDAPQDGTARLGARSPDRGIVFPVDTPVFVVVDGPAASGKSTLAPALAQRLRLPLLAKDTIKDALMEATPPADVEHSQQLGQAAVRVMLALATASPIGAVLESNFYRSRAAVELARLPGRVVEVFCRCDHEIAKARYRDRSGTRAAGHFDHLRADSELWNPEVAEPVAGGWPVVEIDTNTPVELSAAIAALGQAAPWSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB6</accession>
    <name>A0A7K0JQB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoyllysine-residue acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000220">
        <property type="protein sequence ID" value="MST32136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="9739" checksum="31AEB672F281CDA5" modified="2021-04-07" version="1" fragment="single">MGEFRMPSLGADMDEGTLTRWLVRPGDRVAKGDIVAVIDTEKSTIEVEIFEGGTVEQLVVPEGTRVPVGTVLARVGAAPSAAAGAGAAAPEGPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB9</accession>
    <name>A0A7K0JQB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="15190" checksum="579A78574661FDA4" modified="2021-04-07" version="1">MDLDEARSYLRANHHSVLIARKPDGSPQPSPVVHAVDDAGRLVVSSREPAYKVRNLRRDPRVTLCAFPDGFFGTWVVAEGRATIVPLPDALEPLVDLYRQVAGEHPDWEEFRAAMVREQRVLIRVDLERAGPDVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD5</accession>
    <name>A0A7K0JQD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YceI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000226">
        <property type="protein sequence ID" value="MST32156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="3">
        <location>
            <begin position="87"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="259" mass="27168" checksum="7EBB17D232F6F1B3" modified="2021-04-07" version="1">MGQTHPDRGIVGSVPSSPETRQRPAGSPARRAGGRWWLWAGIGSVALAVVFGVLLALDLSSHTPAPLALPRVAGASSGLAAGPVSGTWTVSPDSQVGYRVHEVLFGLNHTAVGRTSKVSGGVTLSGSEVVAADFTVQMHAVKTNQAGRQVMWDDFIMNTGAYPQARFRLTEPIHLGGVPAVGKVVPAHATGALTMRGVTRVITFAIQGERVSPTTIDLHAAIPITFADWKIPRPNLAITKVSKSGTLEVLLHLHPAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE5</accession>
    <name>A0A7K0JQE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_tran_28_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000228">
        <property type="protein sequence ID" value="MST32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="249"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="406" mass="42834" checksum="5888A7479047221C" modified="2021-04-07" version="1">MRTATPLARVLLYSHDTYGLGHLRRNLVLARRLLSSPPAPQVVLATGSPVIDRMPLPAGLACVSLPPVVKTGADQYRPLEPSLDISLVRRARSAVLSDVVRRWKPDALLVDHAPHGMKGELIPVFETIRRSAPGTKVILGLRDILDEPERVVASWRADGVVETLERVYDAVLVYGERSVFDLARLYRLPPSVAGRLEYCGYVAGPPPAAPVAPPGLSPGSDYLLGTVGGGGDGVEILVATARAAASTGLQAVLCTGPLMPAADRARLLHAVGARPDVIVAEHLPDLAGVAAGARCVVTRGGYNTLCELVGLGVPVVVVPRPAPRREQVLRAEAFARRGLVRMVDEGDDLGGSLLEAVSGTTAGPGRPRERLALDGSTRAVDAVRRLVEERPAPPYAATADRLGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG5</accession>
    <name>A0A7K0JQG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF429 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000234">
        <property type="protein sequence ID" value="MST32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="28665" checksum="77E50F9695567269" modified="2021-04-07" version="1">MIVAGVDVAEERKGLDLVLIDVDRRILGSFGRLTVADVVSLLLREHRPDLVCVDSPSGWSRSGASRRAERELAAMGISAFATGADPGDHPFYRWMRVGFRLFRDLAASYPLFAGGALEGRAAEVYPHASAVLLAGRDRAEGETKVAFRRSILRSQGVDEVTLPNGDRVDAALAALTGVHALEGHWTCVGDPAEGVVLLPIGGGLRRGGGRHPQGQPGPVPGGSEQPFELRLGAPEGHQAHTFGYVDEQVHVALGALLPPGDTAEDRGLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY1</accession>
    <name>A0A7K0JQY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="5">
        <location>
            <begin position="11"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="21352" checksum="340F9E0794CB4102" modified="2021-04-07" version="1" fragment="single">MGATAAGEELDILVVGGGVVGAGAALDAASRGLTVGLLEARDWASGTSSRSSKLIHGGLRYLEQLELHLVTEALTERGLMLERLCPHLVRPVSFLYPLTHRGWERPYVGAGLVLYDTLGLGRGWGRGLPLHRHLTRRGVARVCPALRPDAHVGGVRYWDAQVDDARHTMTIVRTAASLGALAANRAQVVGLTRLGERVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ7</accession>
    <name>A0A7K0JQZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="6">DXP synthase</shortName>
            <shortName evidence="6">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">dxs</name>
        <name evidence="8" type="ORF">GHK86_06400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="6">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000276">
        <property type="protein sequence ID" value="MST32351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="316"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="6">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="6">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="628" mass="66234" checksum="A85DFD9B112EB9BA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR05</accession>
    <name>A0A7K0JR05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000280">
        <property type="protein sequence ID" value="MST32376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="490" mass="52017" checksum="C39ECBCD6D3A368C" modified="2021-04-07" version="1">MLGSVRSGWLIPSGPCQRLFDFSRHRLRGEPSDPEEDSMSRLVRSRSRLAVAGVAAAASLLLAACGSSGAASGGTGNAAGTGSSPGTAGSGNVVNLTFWSWVPGIQTSVNLWNKTHPDIQVHLDETTSGTAGTYAKMFSALKAGNAPDLGQVEYSVLPNFEHVGGLDNIAPYVNGFKKDFLGWTWNQVSLGSDVFAVPQDVGPEALFYRADLFKKYGLAVPTTWQQYLSDAEKLHAANPNAYIAAFPAADTQWFAGLAWQAGSDWFTTSGNSWLVNFTSNSSAKVASLWQELISKHLVKVEPDFANGWYKDLSDGTLLTWPSAVWGESTLMTNAASTKGDWRVAPLPSWGSTPSDGDYGGSTTVVFKDSKHPKQAAEFAAWLNTNQQSITSLITKGGLYPADAQGEKQSADNSPVAFYGGQNIWKVFAQGAAEVNTNFRWGPIMSTTFTQLGDAFSAAAAGSGTLSSALSKAQSETLSTMKQQGFAVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR38</accession>
    <name>A0A7K0JR38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000280">
        <property type="protein sequence ID" value="MST32377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="440" mass="47596" checksum="3E43D8AC271F098C" modified="2021-04-07" version="1">MPLGFVDVMELMVEPRRARVHEAGWQSWSPEGTYRVDTTSPRPRRAVWQTMAFRPGRPGPASGFQGEGLLAIDPGDGSPVRLVQGAALPADVPSIRAELVGSGRLRVSADGPVRVVEVAGSLAASLAAWATDTALGAEVSAPARIPPVWCSWYCYWRDVTSEHLLTNEADAHRLGIDVDVIQIDDGWQAAIGDWDLTDPRFGDLGRTVGELRSRGRSVGIWLAPFLAVPDSRLALEHPDWLLPDTDAGFNWGAPLRVVDLTHPGAREHLHDCLRRLALLGVSYFKLDFLYAGAMEGRRHRDVATIDAYRDGLRLLRDGAGPGATVVGCGAPLLPSLGLVDAMRVSPDIMPTWEPPDGDVSQPGGRSAVLAGSARTHLDGRFWVNDPDCLLARPGVERREVWADHLRSVGGLASSSDPLASLDEWGLSVTRELLQRRAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR90</accession>
    <name>A0A7K0JR90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="391" mass="41735" checksum="4A34CAFA80D02AD4" modified="2021-04-07" version="1">MSAAEQWSDLLPEGFEPGAAQVDDARRILLRPASTIQVRPVHWLWEGRLPTGSLSLLAGREGIGKSTAAYTLAGDVTRGRLAGRFYGQPKSVIVAASEDSWSHTIVPRLMAAGADLDRVFRVEVTVADVLPGELVLPDDIDALVDHVRDVDASLVLLDPLISRLDGRLDTHRDAEVRRALEPVAHLADRTGAVVLGLIHVNKSGGTDPLSTVMASKAFVAVARSVLYAMTDPDDEHRRLLGLAKNNLGRLDMPTLRYRIDGCVVADTDEGPVWTGRLIWDGETDQSITDALEAASAPGGKSAMAEATAWLADWLEQQGGGAESSAAKAAGKAAGHSRATLERAAKKLDVAVDQHGFPRRTYWTLPASPRPSTGVGALPVILGLAAWRASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ7</accession>
    <name>A0A7K0JRJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000246">
        <property type="protein sequence ID" value="MST32209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="22097" checksum="130B0256DD12E9E1" modified="2021-04-07" version="1" fragment="single">MHVEHGVEHREVLVGDRAQHLLRKHVGVRHLDSFVVRLGGAPPRSQATRRWPSPGGCDRGRARRCHAAGDGRRGKVWWLPQDIARGADRPVIHVRGDLDVGSASRYLRIVRQGLGGGDRRIDVDLAGVTFVDVAGLRALLDAERAARRSGRELRYCQPSGAVVRLARLLVLPHVRSSIGLDVAGDGGLCAAATAARRCRRPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL4</accession>
    <name>A0A7K0JRL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000336">
        <property type="protein sequence ID" value="MST32588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="23600" checksum="F038245AE189F87B" modified="2021-04-07" version="1">MTTGQIERKRDRIIQVAMRHFAESGYDGARVDDIAREAGVAKGAVFGYFGNKAGLFLAVYQAATRSFDAYLDAPPEVVEQGFFATLGYWFDHTAHLIEESWVPYRVSLLGNYCSDLRTRREITQFLVREDPYGTRAFVQFGIDRGEIRDDIDPKMIVSLVNWSVDGCQDAIVAEELDPGLFAINAPSPERTREYVRQFLELLRSAIGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL6</accession>
    <name>A0A7K0JRL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14532" checksum="45B087D560E90068" modified="2021-04-07" version="1">AQPPLLERAVLNVLDNAAKWSPPGGTVEVRLTRGPTWVLEVRDHGPGIDAADLPHVFERFYRAATARAMPGSGLGLAIVRNVIADHGGTVEAELPPGGGTLVRITLPTVEEDEPVSPAGWSDHPPAPPEPRPRVGQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP0</accession>
    <name>A0A7K0JRP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000339">
        <property type="protein sequence ID" value="MST32602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029578793" evidence="2">
        <location>
            <begin position="30"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="20541" checksum="15E6DD3CDC297678" modified="2021-04-07" version="1">MSAITRWVAVVVLMTVGLVGCSSSSRHQASGTTLGSSSTTRPPVTSATSRPPSLVAPVGKCVASSLRVHGGRQGDGPGASGDLILTETGTTPCVLSGYPTVTLIDQAGLALATASGPPTIEQRARTLHPGASADLVLFWSNWCAKAPGPLWVRLALPAGGSVTGPFNGPPDYNFVPSCLSPGQPSKLSITYAYNNSASGVPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX3</accession>
    <name>A0A7K0JRX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="389" mass="41483" checksum="E82BC0711E2D6926" modified="2021-04-07" version="1">MASFAWSGASRTSRRGVVAHLSPAYLLGRLVGRRVPVVRGVSRLRVRAPGWAWHLVESATLRAGDDAGRMPSPEELDALLAEAGVVGTLAGVTELPSSSGLAVAVLAVEDPARELVLKVAVEPQAVAELRADASVRSRLSEDRRAGEWGRLLPHVLASSLDRSPATSLEQRIAGIGGAALMVGAGPTWRRAYDSAAAAIVELHSRTSEHVRVDADRLRAWVDDPVAVLDGVFAAGGWQRVALRRLQEEISRSLTGRSIAVGWTHGDYSPGNLIFSPGGELAGVVDWGAGSPEGLLQVDTATLGLTTAMLRRRREFGDVVMGALQEAQPAPGGGIGRRPPAGPLSWREAVLLAWLRHVTLNLTKTQRYRRRDVWRAVNVDGVLSVVTRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ3</accession>
    <name>A0A7K0JRZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">GHK86_06330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13813" checksum="72AE857C230AEF4D" modified="2021-04-07" version="1">MIVVDASAAVSALLNAGPARRALAEEQVHVPHLIDPEVANALRRGVAASRVEPGDAWTALGRWRRLGMSRYAVFHLLERVWELRENLSAYDASYVALAESLGCALFTADVRLARAPGLRCPVTVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS08</accession>
    <name>A0A7K0JS08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000369">
        <property type="protein sequence ID" value="MST32720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="11056" checksum="BE73C43CA34DAA21" modified="2021-04-07" version="1" fragment="single">MSDPVGLEDLPDPTVVLDASQRVVALNAAAERLVARPRAEIVGRSLADGAGLTDEADRPVWSGGWGAAARLRGVRLIPEQPARLRRPDGRSVPVLATAAFRRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS16</accession>
    <name>A0A7K0JS16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4396 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000371">
        <property type="protein sequence ID" value="MST32732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="85"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="25691" checksum="28916F46E7915C5E" modified="2021-04-07" version="1">MPPTWLTDLSWAALALAGASAVWIARDQWVRGHRQQMRIMEVVWPVTALYYGPVAVWGYRRFGWPKSPQWRAERRLEHAPERPRWSGVATGVSHCGAGCTRGDLCAEWAVFGFGATIIGLSLLPEYIGDYILALAFGIAFQYFAIAPMRGLGLRAGLLEAAKADVLSLTSFEVGLFGWMALVQLVLFPHHLRPDHAAFWFLMQVGMIVGYFTAWPTNVWLIRRGIKEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS28</accession>
    <name>A0A7K0JS28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000381">
        <property type="protein sequence ID" value="MST32756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="31878" checksum="E9048405E5B45560" modified="2021-04-07" version="1">MSSMNRSGARRATRWPGRAMRRRLTTTAVITNYNYGRYLRRAVASVLGQSAPADRIVVIDDGSVDDSRQILSEMPREVEVILQENQGIIASRNRAIDMCRTSHITFLDADDVMGRRFLELTRCAWSLPHSDRLALAYTAVRLRGPNGTRVMTSAPWSQKMLGRQNYIVNTSLFQLEALKDIGGYSPRFESLGFEDWDLMLKLAESGWRGRFVPLCLVSYFPRPEGRNYSSIRKNGDAVTRALLEEHPWASPGPQGRAYRLGQLLVNAPRAVADRAARLAYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS61</accession>
    <name>A0A7K0JS61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylosuccinate lyase</fullName>
            <shortName evidence="11">ASL</shortName>
            <ecNumber evidence="4 11">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">purB</name>
        <name evidence="14" type="ORF">GHK86_08555</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 11"/>
    <dbReference type="EMBL" id="WJHE01000384">
        <property type="protein sequence ID" value="MST32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="12">
        <location>
            <begin position="67"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C" evidence="13">
        <location>
            <begin position="344"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="471" mass="51229" checksum="053DE67038E3FF13" modified="2021-04-07" version="1">MPQPYPAVGSGTPAGYARPVPISPLDGRYAAQLVDVEAEVSEDALFRWRFAVEVAWFRALAGEPGVVELPPLESALDAALDGWVAGWGAADTAAVRAIERRINHDVKAVEYYLKEKLAAQGVPAEQREFVHFACTSEDINNLAHALMLRDALARAWLPSAEQLVADVAALARAHARMPMPSHTHGQTATPTTLGKELAVWVARWRRQLDGLRALRLTGKLNGATGTFGAHVAAYPEVAWPELSRSFVEGLGLAWNPLTTQIEPHDTLGEAFHLLMRFDAILLDFCRDVWEYVSRGYLRQRPAAGEVGSSTMPHKVNPIDFENAEANLGIADALLGHLAGKLAVSRMQRDLSDSSAIRNMGVAVGHSLLAIRAARRGLGRVEPDAAVMAAELDGQWEVLAEAVQTVMRRYGLPEPYEQLKALTRGERVDATRIKEFVVGLGLPADVEARLLALSPATYTGVAAELVERYLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS67</accession>
    <name>A0A7K0JS67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000389">
        <property type="protein sequence ID" value="MST32785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="353" mass="36589" checksum="53328D850F1D3CCC" modified="2021-04-07" version="1">MSGPLRAGLPGVLQLPGLARWHLAAGRLVTEVATPPGWRYRLVRIGTASGTGAAPTVGTRRESRGHSPGVVDLHRPGHRELAVDVGRDVVTDGSFARGPWQTQVGNCDAVDGRNVGAAVTGNVLAGAGPAGELALRLRASTDSACESTTLRWPGGPLLLSMWVRNLGGAPPRICVWETARRHCAAGTAVLPDSSTWTHVQAVLTPNPAAGSLRLYAYADSLAPGQATVDEYAGIAAYPVRRVGPLALLATPDRTVLRDLRLADSSYTSAWSAPRGRHVLVDGMRNGWLPDAGGAPGGPVRFAPARLEREADLVSLGAALVACALAAMAVARATGRYRHAPIRSGPGQSVGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB0</accession>
    <name>A0A7K0JSB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_08865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000402">
        <property type="protein sequence ID" value="MST32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="26222" checksum="87CB88358392C7F5" modified="2021-04-07" version="1">MTPLLVYGRFEVGRLLRSWRFLLITIGFPVTFYMLFLGDRGAGQVVGGTAWRVYLMVAMCSFGSLVAALTAGGARLSAERSSGWSRQLRVTPLPGWAYVGVKVTASMLVILPVIVLVEIVGATFGGVHLGAGTWVALTAVLWVAAVPYAVLGALIGFLVHAETAFPVVTALLFVLGYFGGLFNPVSEMPGPLRTVARLLPSYHGAAVGLVTVEGRGPLALHWGALAAYVVVLGAVIVVRHRALEAHAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG6</accession>
    <name>A0A7K0JSG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_09105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000417">
        <property type="protein sequence ID" value="MST32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="204" mass="22034" checksum="2D2063F19F7591C6" modified="2021-04-07" version="1">MRPRRQRAPGRGVAGQDHRYTPRIASDDEPLVAEARSGDTRALEALLRRHQDRLFAVCRRLTGSDADAADALQNALIAVVRGLPRFDGRSSFATWSYRIAVNASLDELRSRARRPEPGALADDGPSVADRSDGVAARLDVDAALLRLAPEFRAAVVLRDVCELDYAEIAEVLDVPPGTVRSRIARGRAALVSLLGGRPEPVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ5</accession>
    <name>A0A7K0JSQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-4 C(11)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobM</name>
        <name evidence="7" type="ORF">GHK86_09600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="26577" checksum="6649D921399E3566" modified="2021-04-07" version="1">MISFVGAGPGAADLITVRGADRLARADVVVWAGSLVAASLMDRCRPGVVLYDSSGMTLDEVIRVFAAHPEAAVVRLHSGDPTLYSAVAEQIDWCRANGRPYEIVPGVSSMSATAAAAGRELTVPGVAQSVVLTRLARRTAASVPDHESVAALARRGATMALYLSAGDPEALQRELLCEGSAYTAATPVVIGYKVSWPDEIVRRSTLGHLAGDLSALGKRTSVMILVGDALADLDVPAVSHVYSSAFGHAFRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT48</accession>
    <name>A0A7K0JT48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000364">
        <property type="protein sequence ID" value="MST32699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="19599" checksum="532D176526FBD032" modified="2021-04-07" version="1" fragment="single">MVKRHPVTARRLGTSTLAAFVFLSLPAAVLVLARAPLAEAAHVEQVFTALGVTAGGLACLVSARATGRAFDGWVGVTLVVSGVLVAATADLPLFGFAPTAEGRALQSLVTAAALTPLWVRTYQANEVEAGLQPLRLISLGVIGAVAGVAGVGLLARDGLLLPAGDGAGWREVLAASAACWLGCALQAALVATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA9</accession>
    <name>A0A7K0JTA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000509">
        <property type="protein sequence ID" value="MST33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="74"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="27466" checksum="0D57E83A0204418F" modified="2021-04-07" version="1">MGSRSTQTGDAGSRRPARRWRAVIAAATGALLVATAVVVIVSRRTTANELASVRVSGMPPGISVPVSDLMGLDSLPHRAAPGFQLTDQRGRSLSLRSFRGRVVVLEFMDPHCTDICPIVSQEFVDAYHDLGSARSKVAFVAVNVNQYHLKVSDVAAFSAEHQLDTIPDWHFFTGSYPTLRSVWSAYNIAVESRGPNADVIHSSIIYFIGPHGHERFLASPEVDHTAGHKAYLPADQLTAWGRGIARVAKDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC6</accession>
    <name>A0A7K0JTC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000519">
        <property type="protein sequence ID" value="MST33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="9787" checksum="49CAEE287D464855" modified="2021-04-07" version="1" fragment="single">MVAVVVFVETLFFTAITPLLPHYVAMLHLTKSGAGVLVAAYPLGTLASAVPSGAFAGRAGVKTAVVAGLALMSAATLVFGLGRSELVVDLARFAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD8</accession>
    <name>A0A7K0JTD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Divalent metal cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000525">
        <property type="protein sequence ID" value="MST33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="180" mass="19308" checksum="5FC5758B1076B9D1" modified="2021-04-07" version="1" fragment="single">MKTGPAVRARRDTTAQDGSPIRESERIRVEELRRRKRRWQLAMMLVGPGILTMVGENDGPSMISYAATGRAYGFGLFLPFILVTFAAAAVCQEACLRVGVATGRGFGELVAQRYGPLWGALAAGDLVVSNAVTLVAELVAVRVGFAYFGIGAPVAVGLGLAVLGLGLAGRRYRRWERRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG4</accession>
    <name>A0A7K0JTG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Squalene--hopene cyclase</fullName>
            <ecNumber evidence="6">5.4.99.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">shc</name>
        <name evidence="6" type="ORF">GHK86_10930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.17" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000531">
        <property type="protein sequence ID" value="MST33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051007">
        <property type="term" value="F:squalene-hopene cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="4">
        <location>
            <begin position="332"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="658" mass="72503" checksum="6AA42D593C8EAAD7" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP0</accession>
    <name>A0A7K0JTP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000553">
        <property type="protein sequence ID" value="MST33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16721" checksum="91A2A07032CEEB3F" modified="2021-04-07" version="1">VAVVTGAAKAAACLAWGADVVVDLERGGLLEQLRAAVGPGGAEVVVDNVGGGAFDDLRRVVAFEGRLVVVGFTAGGIGTVPANHVLLRNYSVVGLHLARYRREDPDLLRRVHAELVGLWGRGVIEPAIHRVLPFEEAVAGLAMIARRQTIGRVVLVPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT7</accession>
    <name>A0A7K0JTT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000572">
        <property type="protein sequence ID" value="MST33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="17253" checksum="919247567D94A43D" modified="2021-04-07" version="1">MAFYDASIAALDGSPLDLGRFRGRAVLVVNVASRCGLTPQYEGLERLQGRFGDRGFSVLGVPCNQFAGQEPGSAEEIAAFCSTTYGVTFPMTEKVEVNGPGRHPLYAELTAVPDATGEAGDITWNFEKFLVAPDGAVVGRFRPQVEPESDEVVAAIEEVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU9</accession>
    <name>A0A7K0JTU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000459">
        <property type="protein sequence ID" value="MST33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="32785" checksum="2FE61EE8AB81A5C8" modified="2021-04-07" version="1">MSRTEGWHAPGRWHRVTGAAPDGQAPGERAGADGWMSGLGVRRGSFVPLHRQIHDLVRHEIVAGRLHPGTRLPAEGWLAERWGVSLAPVRQALVDLAAEGYLDRERGRGTFVRQPKFDEKLSILSSFSGSHAEQGDRPELTLLYSGRVPAPAEASAALGLRARKLVLIQRLAYLDSSPVALLSAFLDPARFPGIERRDLHEGSLYRTLDAAYGIELVRAESVIEVVRAADDEAVPLGVGAGAMVLRVDSVTYDKADAAVEFSRVLYRVERFRFSLDSYRLDDRVLHFPASHVRKGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX3</accession>
    <name>A0A7K0JTX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000579">
        <property type="protein sequence ID" value="MST33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="113"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="228"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="447" mass="46069" checksum="DEEEC15E33E9636B" modified="2021-04-07" version="1">MSELLELASRVAGWARDGEQVEAYVARGRETDIDVFGGEVESLSSAESAGIGIRVVRGARQGFAYAGSLDADVVAETLEEARDNAGFASPDEWVGLAEPDGVAAADLDLWRDDLAAYPTEEKVARALELEAMVRAADPRIRQVQSAGWSDSAVETAVASSTGVTATGRRTVCSVSTYVAAGDGDETQTGYGWSVGRSPADIEVSVAAADAVERATRLLGATKPPSRHLTVVLEPMITASLLAIIAGTLDGEAVLKGRSLFAERLGQAVAAPALTLVDDPTDPDAFGAVAYDAEGLATRRNVLVGDGVLRRFVYDSYSARRAGTTSTGSAVRAGYKSGPHAGTRALAPVPGPLGKEQLYAAVGDGLLVQSVSGLHSGVNPVSGDFSVGAEGLLIRGGAPAEPVREINIASTLQRMLLGIAHVGGDLERLPGMAAGVSLAIDEVSMSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU38</accession>
    <name>A0A7K0JU38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000599">
        <property type="protein sequence ID" value="MST33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="9503" checksum="6B642D53C0AD8392" modified="2021-04-07" version="1">MRRARIPGAAGVDPAIGSVLDLARTATVVDVRRAVRRVASGDGTARVDAVLTHVEAAELVAALGSLMDTSTGVSRGEESTRADGPPAALAAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU78</accession>
    <name>A0A7K0JU78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ring_hydroxyl_A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_12295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000616">
        <property type="protein sequence ID" value="MST33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ring_hydroxyl_A" evidence="3">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="27552" checksum="138F129278BAEF1F" modified="2021-04-07" version="1">MDCREFGLAAIRVESWQGCLFVNLSGDAPPLEQWLDEQEDQPRNFERWDLGSLRVAHTTVAEIKANWKILIENYAACLHCPGVHPELVALIPAYRSGSVSEGREDFGVSLATRSSALTATGVTALPALPHLTEQEATSYYGAFAFPNAFLDVSGTFATLTALLPRAADHTTLVTEYLFAPGTMAADGFDPSDVIAFNELVIAQDNGICERVQRGVASRSFVAGVYPDKDSGPHEFDQFYLRHMEAAGVSEPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB1</accession>
    <name>A0A7K0JUB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000630">
        <property type="protein sequence ID" value="MST33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="6861" checksum="F60F3D12707ABC89" modified="2021-04-07" version="1">MPETRMYTVAGMTCDHCTRAVASEVGAVAGVTAVEVDLGTKLVTVTGDGLSDEALRAAIEEAGYEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB3</accession>
    <name>A0A7K0JUB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hflB</name>
        <name evidence="5" type="synonym">ftsH</name>
        <name evidence="9" type="ORF">GHK86_10305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000488">
        <property type="protein sequence ID" value="MST33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="211"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="219"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="636" mass="67124" checksum="3F57321F6B94DD14" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ8</accession>
    <name>A0A7K0JUJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Addiction module toxin, HicA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000666">
        <property type="protein sequence ID" value="MST33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7522" checksum="4B2ABDD4862593B7" modified="2021-04-07" version="1">MKVREVIRMLERGGWSLDRQRGSHRQFRNPRFPGTVTVSGKPSDEVPPGTLASIMRQAGRSGEGERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK8</accession>
    <name>A0A7K0JUK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose-6-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000658">
        <property type="protein sequence ID" value="MST33603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="482" mass="53059" checksum="FA7F3A801B48B005" modified="2021-04-07" version="1">MRGVAGTRETPVVVVANRLPVDQVTLGDGSTEWRPSPGGLVAALEPVVQSSGGTWVGWPGAPDTELDPFDADGMHVVPVALSAEEVAEYYEGFSNGTLWPLYHDVTGEPVFERRWWDAYRTVNQRFADAVAEVADGPGTVVWVQDYQLQLVPDMLRRRRPDLRIGFFDHIPFPGWEIYARLPWRKQIIDGLLGADLIGFQRGGDAANFLRAARSTSGVVTRGSVIERGDGRQLRAAAFPISVDAAALDELSRRPETLARAAELRRDLGNPTTIVLGVDRLDYTKGILHRLRAYGELLDEGRLGAPDVVLVQVASPSRERVEEYQRLRDEVEVTVGRINGDHSAVGHPAVHYLHQTFPKEEMAALYLAADVLLVTPLRDGMNLVAKEYVACRHDERGSLVLSEFAGAADELRQAFLVNPWDIDGLKDAVLRAIAVAPAEAARRMRAMRRRVSEFDVHRWASAFLGGLEMVAESKAERAAPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL9</accession>
    <name>A0A7K0JUL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="23425" checksum="1FF47599C28E76DD" modified="2021-04-07" version="1">MSWSSGKDSAAALAAAREDPDIDVVGLLVTVNAAADRVAMHAVRRQLLEAQAERLGLALHVVEIPSPCPNDVYEQLMSASMDVAIDEGVEALVFGDLFLEDVRAYREQALAATGIRALFPLWGRPTDRLAHEMISSGLRAVLTCVDPAKLPADFVGRRFDEALLRDLPPGVDPCGERGEFHTFVWDGPGFARPIGVRTGEVVTRDGFVFCDVVPVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ0</accession>
    <name>A0A7K0JUQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000674">
        <property type="protein sequence ID" value="MST33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="486"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="574" mass="61681" checksum="DE0E10A7578DBFAA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV05</accession>
    <name>A0A7K0JV05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfurylase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000730">
        <property type="protein sequence ID" value="MST33795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="3">
        <location>
            <begin position="100"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="28846" checksum="31DF71B9ADB70A76" modified="2021-04-07" version="1">MAGLFEALAAALRAGEPVALAEVIEGPEEHFGAKLVVRPGGDPVALGTLGDPDLDRVVTRDALGELAAGLSVTRHYGRHGEARARDVGVFIESFAPPPRMVIFGAVDFTAALARVAKVLGYHVTVCDARPVFATRARFPMADEVVVAWPDRHLAEVGPLLGPRDAVCVLTHDPKFDVPAITAALRTSVGYLGAMGSRRTTLEREGRLREAGVDDRGLARVMAPIGLDVGARTPEETAVAICAEIIASRTGRAAPSLRDAEGPIHRDAPAPAPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV40</accession>
    <name>A0A7K0JV40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000738">
        <property type="protein sequence ID" value="MST33826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8393" checksum="6482069EA1FDF6BB" modified="2021-04-07" version="1">ALRGAAARLEAALAGAGVPHDVKEYPDAGHGFMDRLNAGPAVVALRVAGLGYHHPSAEDAWARILRFFAEHLGDGAPGNAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV50</accession>
    <name>A0A7K0JV50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000745">
        <property type="protein sequence ID" value="MST33845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17509" checksum="8B5F4775251C3054" modified="2021-04-07" version="1" fragment="single">MTVAASEEAVTPVGRPRPVPVAAWAPPGVTTLRADQQAILQLVFDTFCRQFAEELTTVIRLPVELRVRPARLLLWRDVLAELPEPYSACLARWSPDHAGGLVVVSVPLAVAYVDRLLGGPGAPSEHPGPLTEVENELVADLHRRVAAAYAASLAAVAAVDANVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA3</accession>
    <name>A0A7K0JVA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000762">
        <property type="protein sequence ID" value="MST33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029595718" evidence="1">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="199" mass="21086" checksum="CD96028002431681" modified="2021-04-07" version="1">MIAVATALVLVFAAAAVASPLEVSSGRVAYHRAWTVRVTQADRCVRLSATGVFAYEVRPILFGLGHVWYHVVLQDPTVHASLHPYRGCRSRTATAASVHLSQSWSGYRCPYQPQLAANTGSTDIPACASGDRAEYVTSYGSGSTFSQYNSGAWTYFPGRFGNSFSARKCFGFGAGVSFTDNGVTTSAGSPPGSRVCLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF4</accession>
    <name>A0A7K0JVF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000613">
        <property type="protein sequence ID" value="MST33489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="320"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="393" mass="40523" checksum="E12B78126393FF45" modified="2021-04-07" version="1">MHVVVVGASLAGLRAAEALRHEGHDGPITVVGDEPHRPYDRPPLSKQLLTGKVAPEATALDAGDLGAEWRLGVAAAALDLDRRRVRLADGDELGFDGLVVATGSRARSLPVLGAREGVHLLRTLEDGVALRAALTGGARRVVVVGAGVIGLEVASSARACGLEVTVLEMAGTPLERVVGAELGPAVAALHRAHGVDLRLGAVVVDVEGRDRVEAVRLADGATVAGDVIVVGVGAAPAVGWLEGSGIDLDDGVRCDAHLRVLAGGRPVPGVVAAGDVARWDRPGAGPTRLEHWTNAVESAAVAAATLVRGDAAAPYDPVPYVWSDQHDRKIQVVGLHAPGDAMTLVDGSIEERRFAAAFGRDGRLVAGVGFSRPARVMALRRLILDGAPWPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF5</accession>
    <name>A0A7K0JVF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/arginine repetitive matrix protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000756">
        <property type="protein sequence ID" value="MST33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013610">
        <property type="entry name" value="ArdC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08401">
        <property type="entry name" value="ArdcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArdcN" evidence="1">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="293" mass="30916" checksum="3A1DB6E82A7F30ED" modified="2021-04-07" version="1" fragment="single">MSRGDRHAAATTVAAAQEVLAREVDRLVSGEDWQRFLRLQSRLHGYSFGNLLLIEAAHRVAFQEGRVAVAEPSMVAGFRTWQSLGRHVIRGQRGYPILAPLVVRSRPDPAVPGEGAAPEKRAGPTGGRVVVGFRVVHVFDVSQTDGAELPAPPVPSLLVGAAPVGLLQRAGRLIEREGFIVGSAPDAAALGGANGVTDWTARRVLVRADMDDAARAKTLLHEAGHVLLHGDGAGRRLPREVKEVEAESVAFVVGSACGLRSDVYSFPYVAAWFPLPAMSPSTTCTAEGGGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG2</accession>
    <name>A0A7K0JVG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription-repair coupling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mfd</name>
        <name evidence="10" type="ORF">GHK86_14535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000776">
        <property type="protein sequence ID" value="MST33931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="620"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="806"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117596" checksum="51056F6655301FBF" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI4</accession>
    <name>A0A7K0JVI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ACR3 family arsenite efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ORF">GHK86_14390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000766">
        <property type="protein sequence ID" value="MST33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="37838" checksum="1BA22A6F42E206B3" modified="2021-04-07" version="1">MGRLSFVDRFLPVWILAAMGLGLGLGRGVPGLNRALDSVQVTSGTSLPIFVGLLVMMYPVLAKVRYGQVGAVSRDRRMLVSSLVLNWVVGPAVMFALAWLLLPDLPAYRTGLIIVGLARCIAMVLIWNDLSCGDREAAAVLVALNSLFQILMFSVLGWFYLKVLPGWLGLSTVGLHLSIGRIAETVAIFLGVPLVAGFLTRTIGERAKGRAWYEQRLLPRLGPFALYGLLYTIVILFALQGHTITTHPGDVARIALPLLAYFALMWFGPFLLGRRLRLGYERTATLAFTAAGNNFELAIAVCIGVFGVTSGQALAGVVGPLIEVPVLVSLVYVSLWARRRFYPAAPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN1</accession>
    <name>A0A7K0JVN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000806">
        <property type="protein sequence ID" value="MST34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="74"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="584" mass="61405" checksum="AF8CE0496F38C747" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU1</accession>
    <name>A0A7K0JVU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_14945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000811">
        <property type="protein sequence ID" value="MST34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="19073" checksum="C7D69C223D7B26AF" modified="2021-04-07" version="1" fragment="single">MTAGTNGPGWPGGTGVPGGGDRPGSSPEDALFARRIVQLRGPLDEATAGDLAARLMYLDGSGDEAVTLYVDSPGGPLHAAFSVLDTIALLGVPVDTVCVGRAEGTAVAVVAAGRRRHAAPHARFRLGEPDVSVSGRADQLQSWATYHAEQAARLAGALAAATGQPAEHVEADLAAGRWLDAEQAQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY9</accession>
    <name>A0A7K0JVY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000854">
        <property type="protein sequence ID" value="MST34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9721" checksum="480860DEC646B194" modified="2021-04-07" version="1" fragment="single">MKPTSSPTTRSSCEEPDEPSRYELAWQLAHSGLEPDDAIDAVAYALGVPHGVASGLVWAEMARPVACRPRLHWEDGRPPAREGMWRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW47</accession>
    <name>A0A7K0JW47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000883">
        <property type="protein sequence ID" value="MST34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="412" mass="44939" checksum="6F17EB60B439FE69" modified="2021-04-07" version="1">MAVASMIDPVGWLGKYLEDPEADTDLPRAMLKSFAEAVMSAQASLQCGAGYGERSAERENSRNGYRTRPWDTRVGTVELSVPKLRRGVYSPEFLLTPRRRAEQALVAVICQAYVEGVSTRRVEDLVAAMGIEGISKSQVSRIAGELDQLVGEFLSRPLDAGPYKYLWVDALTQRVREGGRVVNVSVVIATVVGAEGRREIAGIDVVTSEDTASWTEFLRCLVERGLTGVELVISDAHGGIKAAIASVFAGAAWQRCRTHFMANLASRVPKSSWPMVATLVRSIFEQPDRDATWAQLETVVDKLTGTGFADAAAFVLDAAEDILAFTAFPVEHWPKIRSNNPQERLNKEIRRRTDVVGIFPNRAAVIRLVGAILAEQNDEWAITKRYMRAESLKTATAALAAGPPAPDQTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW85</accession>
    <name>A0A7K0JW85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_15605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="WJHE01000867">
        <property type="protein sequence ID" value="MST34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="303"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="238"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="416" mass="43783" checksum="57B6B3F09017EEEC" modified="2021-04-07" version="1">MGAGYVGLTTAACLAHLGHDVTCGDVDEQRVAALADGVIPIHEEGLQELVRAGLDAGRLRFVVGAGPAADGAAFAFLCVPTPQGQDGSADMRIVQEVAAEIGPRLGQDAIVVNKSTVPVGSTRVVERSLGRRLAVVSNPEFLREGSAVHDFLHPSRIVIGADDQAAAIRVVDLFDGVGAPVVVTDPPTAETIKYASNAFLATKVSFVNAIANVCEAVGANVREVTLGMGYDRRINSEFLRPGPGWGGSCLPKDSAALVRIAEDAGYDFRLLKGVIEVNAQQQERVVAKVIRAAGGSVRKKRVAAWGLTFKAGTDDLRESPALVVIDRLVDAGATVTAYDPTRKEPLPGMAVAADPYDACEDAAVLVVLTEWDEFRWLDLAIVRNRMATPHIVDTRGLIEPAAARRAGFALSGVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU3</accession>
    <name>A0A7K0JWU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000995">
        <property type="protein sequence ID" value="MST34415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="82"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="30847" checksum="67E937F030A39628" modified="2021-04-07" version="1">LPADGSDVSSPDGAGSRPGLLPGSTQHLANPPTAVPTHDPGVEAWLKERARADEAMQAAAETRTAEPPPIAGEGSTEDVIDVLGWDHNQVKFLLEQLEAIPGVRKGGTETQLHQRLSIVDMIRVRLSRHEVVEEAHFWPAVREMLDNGDTVADHAEQQEQEGKDLLQALAKLDADEDEFDQKVEELVLALRKHVAYEDSVFLAFRPSTTDEQRAQLGRRVLHAKEHAPTRPHPHAPDEGTAAKVAAAMAAPLDRARDRLGDRPAQQKGKPSQRQRPRRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX3</accession>
    <name>A0A7K0JWX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3604 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001011">
        <property type="protein sequence ID" value="MST34448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022028">
        <property type="entry name" value="DUF3604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12228">
        <property type="entry name" value="DUF3604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="443" mass="48038" checksum="DDF09CC851639E22" modified="2021-04-07" version="1">DEPELDDFYRYAFDVCEYDFWAVTDHAENTSPYQWWSIQKLADVLHVPDRFVPFYGFEWTSATGHQNVVYESATRGAPIYSSTAEGSATPAQLWAHLRDAGQRSLTIPHHPGSAMVPFDWSYHDEGMMRLVEVFQACRGNYEADGCFRQFSDGTLSGTFVQDGLLAGHRFGLIGSSDHGNGAGYVGAYAEALTREAIFDALHARRTMAATTRDVVVDARLDGTFMGGVAAPSSHPTLAVRAQAYGELARIEVVTPAGVVRRAAREPEVPAGQVAVPLRVEWSTGETSHTDWSGRLRVEGGTVLATRYWSPEIVDVTVDGIAWKAETRNFRSQYGAQRGGVELTVLGPPDAVVRVDTAAGAGAVRLGDLATPTTVGAGRVELARGEQGTLMLQRGTGGLLGLGTDALTTSWELDVTEPTWVYVRVILEDGEMAWSSPIWVAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY1</accession>
    <name>A0A7K0JWY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001019">
        <property type="protein sequence ID" value="MST34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5117" checksum="CD37E5DAB00C10A2" modified="2021-04-07" version="1" fragment="single">MADTITISLPDGATRELPAGATGADLAAAIGPRLAKAAVAVVVDGAEADLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX69</accession>
    <name>A0A7K0JX69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hflB</name>
        <name evidence="5" type="synonym">ftsH</name>
        <name evidence="9" type="ORF">GHK86_17670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001063">
        <property type="protein sequence ID" value="MST34543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="217"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="225"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="684" mass="74367" checksum="C9498F97CA3E3DA1" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX71</accession>
    <name>A0A7K0JX71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000866">
        <property type="protein sequence ID" value="MST34139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="445" mass="47860" checksum="9DABB223D4D84084" modified="2021-04-07" version="1">MFEFDEQLAELVLAYCRERLALAPVPLDLPGAKAELEDALAGLLRPGGNDPAHVLEIFAEKLAPAVLSCDSPRFLSFIPAAPTKAALLFDMVVSCSSLQGTSWLEAAGAVSAENQVLRLLADLAGLPDTAGGVFVSGGSAGNLSALVVARDLSRRRGVTVDRPKVAVSEQAHTSVAKALHVVGMDALVVPTEDRRLTAGQLRAAVAGHEHELAAVVATAGTTNAGIIDDLEGVGALARELGVWFHVDGAYGGAALFSERIRPRYAGLRHADSFVVDPHKWLFAPFDCAALLYREPRYAKAVHTQDAGYLEVLHTDAPEEWNPSDFAYHLTRRARGLPLWFSLAVHGTDAYRDAVDAALDLATAAVELIGQRPYLELLREPELSVVLFRRPGWTAGDYHTWSFRLLADQVGFVTPTVWDGETVARFCFLHPGTTPAMVAEILDTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB2</accession>
    <name>A0A7K0JXB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001089">
        <property type="protein sequence ID" value="MST34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15327" checksum="96C13F739AB3130A" modified="2021-04-07" version="1" fragment="single">MLLQRAALVARVDRNRGPDPLAGLKVDDDDVAALLAELPGLESDGVAAGDRLHAALEDHVAEARALLHEGVAAGADRFASLAHGARLAAPDVEVLAVLCAVEADPRRQRLVGYLHDDVTLRRVTPWLLARLFATRDAPLAAVGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC0</accession>
    <name>A0A7K0JXC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_17950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001090">
        <property type="protein sequence ID" value="MST34597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="255"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="405" mass="43898" checksum="0B5C465EABB78405" modified="2021-04-07" version="1">MSQFSLELDEDQLQIVKWVHDFAEGVVRPVAAEWDEREETPWPVIEEAARVGLYSLDFVTNCFADPTGVLLPAVMEEMCWGDAGITLAIFGTSLGVSGIVNNGTPEQIGEWLPQCFGTPEQPALAAFAVSEPDAGSDVSSMRTRAVYDEATDEWVLNGAKTWITNGGIADVHVVVASVDPALKGRGQASFVVPKGTRGLSQGQKFKKMGIRASHTAEVILDDVRIPGRNLLGGKDKLDARLARAREGRTGQRGQAAMATFEASRPLVGAQAVGIARAAYEYALAYAGERRQFGRAIIENQGIAFKLADMKVAVDAARLLVWKAAWMARNGKPFEAAEGSQSKLFAGETAVRVTEEAIQILGGAGYVKDHPVERWHRDSKIYTIFEGTSEIQRLVIARAISGMHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF2</accession>
    <name>A0A7K0JXF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001116">
        <property type="protein sequence ID" value="MST34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="20762" checksum="EAB160F641A01965" modified="2021-04-07" version="1" fragment="single">VGFEDPGAADDDATAPADDPLTAADLGRELRHTPEVAEALDRMWPVLTPQALLHDLLGAPALIDLAGEGILTGEERAVLHRPRSATLADVVWTDADVPLLDEAAALLGPTRRRAGAEEELRTYGHVVVDEAQDLSPMQLRMLARRSLSGSMTVVGDIAQATGGWAPTSWRQIVEHLPARRGWRLAELTVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP0</accession>
    <name>A0A7K0JXP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001175">
        <property type="protein sequence ID" value="MST34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="455" mass="50748" checksum="7E342B92B71270B6" modified="2021-04-07" version="1" fragment="single">MHQRLEELTGGRRLRHRDAARDLTRLPDPAVPAGTDRVPQIRHVVILMMENHSFDNYLGTLGHGDGLPDPLPTNPAADGRPVAVRHFRSVAQREGAPSQSWRASHVQWHEGANDGFVRSVEELDVAAPDDAAMGYWDADDLPFYADLARTFPLADRWFCSCLGPTFPNRRFLVSGTANGLIDDELASIIDYPRGGTIFDLLDRYGVSWANYHHGSGRELSRGRFLAGGRLQLDRRARLLGRHLFPRFVGQVRGQLQCTANLYPLGFLRIRRHLLPIERFFAAAGAGTLPAVSIVDPDFEHASEENPQDVQLGEGFAAAVVDAVLRGPGWRHTLLVWLYDEHGGYYDHVPPPAAVEPDGVRPRSLLDAGQPLRWLLRHSGLGRHVREDDGAAGRYDRLGFRVPAVLVSPWSKPGFVSSEVYDHTSVLKLIEEKWNLPPLTERDAAARAPWDMVDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ5</accession>
    <name>A0A7K0JXQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001180">
        <property type="protein sequence ID" value="MST34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="294" mass="32066" checksum="A15D0A6635F7D920" modified="2021-04-07" version="1">MTEGHADAACTRDGRRPGGVPVVSTARGRTQLGNRLLDALPLPDRNRVAALLARERGEHKQILYAPGARIEALYFPVDAVASILTTLTDGAGVEIATVGNEGMLGSPVVLGSDAMPSREFCQVRVPGELLRMDRSSFAEVLSQDDPFRHIIQLYVQALFTQIAQQVACNALHSVEERCCRWLLLTHDRVQKDSFPITHEFLAQMLGVRRASVTLAAGALQTAGLVSYRRGEMTIIDREGLEDVSCECYHVLRDEFDRLLGPTLPKGAVAPSATRRSQRPAAKRARRSSARAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT8</accession>
    <name>A0A7K0JXT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001160">
        <property type="protein sequence ID" value="MST34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="16317" checksum="14B8F8B26E8DEF3E" modified="2021-04-07" version="1">MAAAGVPAHITLIVPWLPPDAIRPADLDDLAEVAATTASWDFALTEVAWFGRRVLWLVPEPDEPFRALTLRLAERFGTPPWEGAFADVVPHLTVGHASGDPEALERIEKKLSAKLPVRCRAGELWVMVAADRQWKVRARCPLARPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX3</accession>
    <name>A0A7K0JXX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000971">
        <property type="protein sequence ID" value="MST34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="7541" checksum="1D8C9AACEB8D2E52" modified="2021-04-07" version="1">DAADATEMAAAVPGVPPGGPANAAVVATLLALSRLVTDHPEIDAVDVNPLVLGPGGGVAVDALVVVGSPHHPQPQGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY41</accession>
    <name>A0A7K0JY41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001274">
        <property type="protein sequence ID" value="MST34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="148"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="408" mass="42630" checksum="75257B30EC09C111" modified="2021-04-07" version="1" fragment="single">SRLHLRRLPTEGPAVLVGPGENAGVVDAGGGVAVALRIESHNHPSAIEPYQGAATGVGGILRDIFTMGARPIALMDPLRFGSLDDDRSRWIAGGVVAGIAGYGNAVGVPTVGGEVVFDDTYTGNPLVNVLCAGLLPKDRLVLGRATGVGNLAVLLGSSTGRDGIGGVSVLASAGFTDDAAAEEAKRPNVQVGDPFEEKRLIEACLQLLDEGLVIGIQDLGGAGLACATSETASRGGVGMDVDVTAVHRREPGMEAWEVMTSESQERMLAIVTPGHLDRVLEVCARWEVRASTIGRVTATGQLRILDGWDGEVLADVPAATLHEDAPLYDRPRRRPADFEQRAADDPARLAPPEDPGKDLAALLIDPAWVYRQYDHQLFLNTVEAPGGDAALLRLAAPGVPSDRGPGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY63</accession>
    <name>A0A7K0JY63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VUT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001287">
        <property type="protein sequence ID" value="MST34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="15852" checksum="23D4101DD8E66F02" modified="2021-04-07" version="1" fragment="single">NWMIAHVGRPLGPNHVLPVGFGLVAPSGVYLAAVTFVARDLVQRFGGPRVGLAAIVVGAALSAFVASPRLALASGATFLVSETCDFLIFTPLQQRNLPVAVLGAGLVAEVVDSVLFLTLAGIPLAVALPGQLVGKGWVILAGGAVTALLRRARPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD7</accession>
    <name>A0A7K0JYD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001333">
        <property type="protein sequence ID" value="MST34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="17304" checksum="9C04603B8A4B317B" modified="2021-04-07" version="1" fragment="single">PDWSVGDLLEHTGSVHRWAAAVVEGGERVRRRDLPAGPPGDAVLDWFAEGLERLTGVLLASDPARRVWSFAAGSPSTVAWWVRRMAQETGMHRRDVEAAGGGAVRGFDPRRAADGIDEYLFDFLPGIPDEDLAALSGPGGGGGSLHLHATDTGVGGGGEWVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ5</accession>
    <name>A0A7K0JYJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001362">
        <property type="protein sequence ID" value="MST35016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_assoc_2" evidence="3">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="MgsA_C" evidence="2">
        <location>
            <begin position="216"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="286" mass="30067" checksum="6D3965C8D5AA2D3E" modified="2021-04-07" version="1" fragment="single">LSELHLTGSKDVHGLALVDDVAGKTTLAQLIAGATTREFVPLSAVTAGVKDVRETVERARRLLGEQGRGTILFLDEVHRFNKAQQDALLPAVEDGTLTLIGATTENPFFSVNAPLLSRSTLFRLEPLGPDALRAVVRRALAAEGASATDAAVDLLVGLVDGDARAVLTSLEVAIALAGDGPVEVATIEAARSTRALRYGQDEHYDVISAFIKSIRGSDADAGLYWLARMLAAGEDARFIARRLVILASEDVGMADPLALVVADAAARAVEFVGLPEAQLNLAQAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS9</accession>
    <name>A0A7K0JYS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001443">
        <property type="protein sequence ID" value="MST35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="12361" checksum="9470098E27960EDC" modified="2021-04-07" version="1" fragment="single">MLAVVITLAVVVGLLGVLVTGLLRSHADIVRALHGLGAGVGDPAAAPPAGPGGVGVGVELRLPAERSAGVHDLEGATPAGDPVVVSVAASPRTLLAFLSAGCSSCAPLWEALGDPAERGLLPPGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY5</accession>
    <name>A0A7K0JYY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mraZ</name>
        <name evidence="10" type="ORF">GHK86_20850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001483">
        <property type="protein sequence ID" value="MST35168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST35168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="16637" checksum="8FB137AD8046BB0F" modified="2021-04-07" version="1">MFFGRYEHSLDAKGRVVLPARFRLSFDSQAYLTQYLDGCLALWTPEEFGKRLAEYSQAQARSSADRNLARVWAAGSQEVEIDRQGRLALPQHLKEFAQLDRNVLVVGAMERIELWDPTQWEARVRPAELNLTDPVDVASAPLDDSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ00</accession>
    <name>A0A7K0JZ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001476">
        <property type="protein sequence ID" value="MST35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14441" checksum="AB515DAFB22A5199" modified="2021-04-07" version="1" fragment="single">MVVGVDGSAGSLRALRWALEEATLRRAALQAVMVWRGVEADDETAFEFATFRSLADYDRGVATLAGEHLRALLSQALGEAAGRVEPIVLEGHPVAALCAHAAGADLLVVGSRGHGAVAEVLLGSVSAACARRSPCPLVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ01</accession>
    <name>A0A7K0JZ01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001207">
        <property type="protein sequence ID" value="MST34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="13075" checksum="90D6671AA89AFC5C" modified="2021-04-07" version="1">MHLEIGIDCSDPDRLADFWEAALGAPGRRGDGRPYVQLLDVPGLPPVYFQRVPEGKVVKNRLHLDLFVADIEREVERLVALGATAHEEVHEGGERWRVLTDPEGNEFCICKEGGSAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ47</accession>
    <name>A0A7K0JZ47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001548">
        <property type="protein sequence ID" value="MST35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="15250" checksum="EB220D9DD7BFE347" modified="2021-04-07" version="1" fragment="single">MSPAIPLAVAAGLCTAASTTCQRAGALRAPDDGQIDAGLLLRLVRQPIWLLGVVSMVLGFVLQATALHFGSLAMVQPILASELLFVFAYLALANPHLVRRRDGLSAVGMAVGLGAVLFTADPSGGRAAAPSGRWALAGVVGAAVVGVLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ48</accession>
    <name>A0A7K0JZ48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001534">
        <property type="protein sequence ID" value="MST35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="28531" checksum="D0FD0FEA7107CDBF" modified="2021-04-07" version="1" fragment="single">RLVTHPDVDAVVLTGSWDTARMFLGWRPGLHLHAETSGKNAIVVTAAADLDRAVADLVHSAFGHAGQKCSAASLAIVEASVYDDERFRRQLADAAATLRPGPAWDPATTIGPLIRPAEGPLADALTRLEPGEHWLLAPRQDPRNPQLWSPGIKLGVAPGSPFHLTECFGPVLGVMRAADLDEAIAWQDQPAYGLTAGLHSLDPAEISRWLERVQAGNLYVNRHITGAIVRRQPFGGWKRSVVGPGGNMAYLRRELLSIGGFDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ72</accession>
    <name>A0A7K0JZ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.68</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cofC</name>
        <name evidence="1" type="ORF">GHK86_21385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.68" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001568">
        <property type="protein sequence ID" value="MST35271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="21433" checksum="32886AFA2D6D9758" modified="2021-04-07" version="1">MATPSAAAPGWFGPAAVLVPVKAFADAKLRLSAVLSPGRRADLARRMAEAVVRSGRGLPVAVVCDDREVAAWAREQGALVVWAPGRGLNRAVQQGVAHLAGYGAELVIVAAGDLPLADDLRWVADFAGTTIVPDRRRDGTNVLAVPTSSRFAFSYGPGSFARHLAEARRLGGPVRVVEAPTLGWDVDVPGDLAGVAGAAGMLPPDTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB0</accession>
    <name>A0A7K0JZB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001597">
        <property type="protein sequence ID" value="MST35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="1">
        <location>
            <begin position="13"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="27494" checksum="9A6D40E5A74B9608" modified="2021-04-07" version="1">MEVVIVDRPGDGAALVAGAIAALVALRDAPVLGLATGGTPQPVYDRLADDCSAGRLSLAGASAFLLDEYVGLPAGHPASYRQVIEREVVARTDLRSEAVHAPDVAGEERELPAACARYDDAIDAAGGVDLQLLGVGSDGHIGFNEPGSSLGSRTRLKTLTARTRADNARFFDGDPEAVPHHVVTQGIGTILAARHLVLLAWGDGKAEIVARLVEGPVSASVPASALQLHHHVTVIVDEPAASRLERAGYYRETWASKPAWQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZM6</accession>
    <name>A0A7K0JZM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001652">
        <property type="protein sequence ID" value="MST35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="9452" checksum="9643D226DD4C8CFA" modified="2021-04-07" version="1" fragment="single">MVEQGVIERVLGAALRTGGEFAEVFAEDRRGTAAVLDDGRVENLASGRERGAGIRVVAGDTTGFAHTSDLSEEGLRAAAAAAAAAAQRGGGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZR9</accession>
    <name>A0A7K0JZR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine-phosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001697">
        <property type="protein sequence ID" value="MST35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="10249" checksum="CCEA7DFFB1337AB7" modified="2021-04-07" version="1">AMVDVSDGFAADLWHLADASGVSFELDEVPVAPGATTAEALGGGEDYQLVFAAPEPDEAVLDAFGALPKPAKVGFCTSRHGTGRLGGKQLPATGWEHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0F0</accession>
    <name>A0A7K0K0F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001550">
        <property type="protein sequence ID" value="MST35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="8103" checksum="8AAE5A6016089BBD" modified="2021-04-07" version="1" fragment="single">MRKDDSEPAGTEEPCDLPATELARLLRGRQLSAREAVTAHLARLERTNGLVNAVVTVTAEAALQAAARADDHLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0F9</accession>
    <name>A0A7K0K0F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001559">
        <property type="protein sequence ID" value="MST35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="224" mass="23947" checksum="C035E7524E5291CF" modified="2021-04-07" version="1" fragment="single">MLDGRFRRGVDRCVRPFGAALVRTGVSPDVLTATGLLLAVPTAWAIGSGHLLLGLALLIFSAVPDLLDGALAKAAGRATVRGAFFDSVSDRVTDTLVLGGVAWYLQGRDGGHAFALPLAVLGASLLISYQRAKAESLGFDAKGGLMERAERVVVLCVGLAFPVLLLPVLWVMLALTLVTAGQRFVKVWRQASVDVPAPARRWAPTGSRPRRSWLEVAERRRVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0P0</accession>
    <name>A0A7K0K0P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_21760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001648">
        <property type="protein sequence ID" value="MST35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="9512" checksum="67A29EA2979B9B11" modified="2021-04-07" version="1" fragment="single">LAVGSLTALLGFLVAGGLANGAMQPAVNLLLARTVDDRRQGLAFGVKQAAIPTSTLLSGLAVPALALTVGWHVAYLVAAGLALLVGAMLVLPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0S6</accession>
    <name>A0A7K0K0S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001665">
        <property type="protein sequence ID" value="MST35359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="195" mass="20730" checksum="20A5BB109A195A63" modified="2021-04-07" version="1" fragment="single">LVDSEPISAAVTAELLTARGVPLATEDVLARFTGLSAATTKAIIEERFGVRLGEDFDRDKRRRLDAAFDARLRPVPGMPELVGSLAATGRRFCVASSSTPHRIDRSLAVTGLDRHFPPAVRFSATMVRHGKPAPDLFLLAAARLGVEPAACVVVEDSPFGVEAGLAAGMTVVGPWTPSRSSPTEPALRNRHEQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JME4</accession>
    <name>A0A7K0JME4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="16230" checksum="0BD5D174C522EB22" modified="2021-04-07" version="1">MRREQIAGFEVRLDVAYDPGTHLWVEVLDSGRVAIGLDPLVVESNGTLAAVAFGVVGTRVARGEPFGSLEAEKFVGPLTAPLEGVLAAANGAVVAQPSLVHTDPYGAWLVELDASDAERDRVQRSWISGEATVRSWFAAEVAEYRLKGVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMS7</accession>
    <name>A0A7K0JMS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="30954" checksum="D0D40125261EC730" modified="2021-04-07" version="1">MDALLELGTLLRTWRGRLQPVDVGSPFGSTSTRTAGLRREEVAWLAGVSPDYVKRLEQGRAHPTASVVYALARALRLSEAETATALRLAGHASDLRTLMPRRITPSVRRILDRLPDTPVGVFDAAWTRLDQNPLWTALTGDPRGHGSRDDNLVWRNFLGEPSRVRHPQPEEYRASLVADLHRVQIRYPNDSELASLVAALRQHSGEFARLWDCSVLGEHGNERKTIDHPELGPIELDCDIVTVQGTELRLIVFTAEPDTTAADQLQLLSVIGSQRLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN47</accession>
    <name>A0A7K0JN47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AarF/ABC1/UbiB kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000050">
        <property type="protein sequence ID" value="MST31375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="461" mass="50461" checksum="9FD5D70E8F6718F7" modified="2021-04-07" version="1">AGRALELARLGSRVGGAWVGDSARQVFASAGRREQLRSDRQLRTTAEVVETLGSMKGAFMKLGQMASYLEAGLDPEVRRQLAQLQADAPPMSTELAASVLEAELGAPPGEVFDTWDPEPLAAASIGQVHRAITRDGRAVAVKVQYPGVDAAIRADLDNSATLLAVIRLAFPGLDADSLVAELRARIGEELDYTLEARNQQMFARYYEGHPSVHVPAVVPELSTRRVLTSELVVGSRYEDVLGWSQAERDLAGETIFRFVFGGLYSMHVFNGDPHPGNYLFHGGGRVTFLDFGLVKWFQPAEVDLLAGMVRAAVTERDDHAFRLAVERAGFLRHDPSLSDAQVAGYFRHYYELVLEDQEVRFSADYASDTLRHFFDAGDPVLKRANVPPPFVVLQRINLGLYAVLAGLGSQGNWRRVAEEVWPWVAAPPSTALGEAEVAWRARTGRLQVGDPTLRRDGVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN49</accession>
    <name>A0A7K0JN49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GYD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000056">
        <property type="protein sequence ID" value="MST31392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014845">
        <property type="entry name" value="GYD/TTHA1554"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08734">
        <property type="entry name" value="GYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="12969" checksum="2E45BF47FBB77178" modified="2021-04-07" version="1">MPKYLVQASFAAEGARGTLHEGGTQRREAVAKLAESLGGRLESLYFAFGDEDVYCILEMPDNVSMAAASMTVAAAGHHHVRTAVLLTPEEIDQVRASTPEYRSLEVGDTLTEHGPGPFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JND0</accession>
    <name>A0A7K0JND0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10840" checksum="540D194B50805EBD" modified="2021-04-07" version="1">ALWRAAWERFTPFLAFPASIRKIVYTTNMVESVNFQMRKASKTRGHFPDDDSALKLLRLIARGISTTRGGEAGTGTWGWTEALNAFAMHFPNRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JND6</accession>
    <name>A0A7K0JND6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_01705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="514" mass="54362" checksum="AC242FB0B91D5F49" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE7</accession>
    <name>A0A7K0JNE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_01840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000075">
        <property type="protein sequence ID" value="MST31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="350" mass="35789" checksum="9C7EB7B6F1BAF741" modified="2021-04-07" version="1">MTTVVYPLIIATLLTALLLPVQARLQRLRLPRAVAALVTLSVAVVVLGGVLVAVVDRATSQAPELGHQIDRLVPHVQHWLRRGPLHVASPTVNHLAASVTRLLGKNSSGIASAALSTGKAAIDLVAGIVLAVFITIFLLYDGEGVWQFLLRAVPRAGRERGDAAGRAAWATVSHYVRGTLILAAFHGAAIALTLALLGVPLVVPLAVVVALGSFVPLVGAVVAGVVAVGVAGLTQGLGAALLVIVVLIADSLIEAHLLQPFVVGRYVRIHPLGIVLALATGAILFGIMGALVAVPVAASVNSGVRALVGTPEPPEPMDPARVPPEPPTPSTAGARTGHAREEATVPGDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH1</accession>
    <name>A0A7K0JNH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="2">
        <location>
            <begin position="102"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="274" mass="30232" checksum="45C2BF87D4CA0232" modified="2021-04-07" version="1">MSGYEAKAYLALLQAGTPVNGYEVAKRSGVPRSTVYETLSKLVARGAAFEVRDGSSNGSTAYLALPAESLLSRLRRQFDTRMAALSTSLPEVVAPVDASLMHNIRGRPNVIERARGLIDSATEDLFVSIWPVDAESLLDNMERAAQRGVEVFVMSFGALGRSIGYTYEHQFSSDEVVLERTGVRLFTICPDRRSVLIGGAFEGDMWAMWSDDPALVLVAAEYVRHDIAMQVLVERMGADAVKAFWDVDPALVRLQHGRGAARLPVRRTVRTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN4</accession>
    <name>A0A7K0JNN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000016">
        <property type="protein sequence ID" value="MST31194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="344" mass="37944" checksum="2207BD2A8D437643" modified="2021-04-07" version="1">MEHRTLGRTGVKVSPLCLGAMMFGAWGEPDHDESVRIIQRALDAGINFIDTADVYSQGESEEIVGKALAQVDRSQVVLATKFHGSMGDDPNRSGNSRRWIMQEVDNSLRRLGTDYLDLYQVHRPDPTTDIEETLSALTDLVRAGKIRYFGHSTFPAHQIVEAQWAAQRRGTERFVSEQPPYSMLVRGIEAAVLPVCQSYGIGVIPWSPLGGGWLSGRFGSGKDNSSRRAERLPGRYDLSKPANQRKMEAVDRLQALADEAGMSLIHLALAFVLEHPAVSSAIIGPRTMDHLEGQLGAAEIRLDRDLLDRIDEIVPPGTDFSLDDAGYVPPALARPELRRRPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT3</accession>
    <name>A0A7K0JNT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemerythrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000023">
        <property type="protein sequence ID" value="MST31239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="41"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="23402" checksum="9C9B76E0A93AE138" modified="2021-04-07" version="1">MAASYPPAALSRLHPGGAGGCPGGPVGYARRQEVRTMTDAFTVLKADHTEVEALLTRLTGGAGPASAASPDPARDAETLVMAESRHEAAEEMYFWPTVRERVADGDALANEAKAQEAEGKRVLDELRTCAPGDGRFEELVATFAAAGRAHIDFEETQVWPKLRAVLTPADADKLGDELTRAKAAGPTRPHPDAPDSPGALKTTGVAAAAMDKVRDAVSGRGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV1</accession>
    <name>A0A7K0JNV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_00665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="WJHE01000025">
        <property type="protein sequence ID" value="MST31244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="12">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="146"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST31244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="942" mass="102539" checksum="C5A95DDB1DDDFEA5" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV5</accession>
    <name>A0A7K0JNV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SidA/IucD/PvdA family monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="414" mass="45262" checksum="6B6A95329F06AFE0" modified="2021-04-07" version="1">MTSDTDVVVVGGGQAGLAVSEHLGALGVRHVILERHRIVERWRTERWDSLVANGPAWHDRFPSLEFFDVNPDGFASRDQVVEYFITYAEKIAAPVRCGVEVTSVRAHAGRLGYRVETTDGIWDARFVVAATGPFQRPVIPAILPADAGVEQLHSSAYRNPGQLPDGAVLVVGAGSSGAQIADDLRRAGRSVHLSVGPHERPPRRYRGRDFVWWLGVLGRWDAETPPQGAEHVTIAVSGAGGGHTVDFRSLAAGGVNLLGMARSWEDGNLRFADDLERNIAAGDASYLALLDDADAWAEHNGAGLPEEPAARQLGPLPDCVRNPQTELEVAGLGAIIWATGYTTDYGWLDVDVFDERGKPRHRRGVSAQPGLYFLGLPWLSRRGSSFIWGVWHDARYIADHIATQRSYLAYERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ7</accession>
    <name>A0A7K0JNZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000031">
        <property type="protein sequence ID" value="MST31284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="50" mass="5698" checksum="D210156F54DCB8C2" modified="2021-04-07" version="1">MSEWRFERRQDLEAVLRMELPADVADPWLARHPAATGLSCGYVLFAAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA9</accession>
    <name>A0A7K0JPA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10575" checksum="11EAED0D20D38354" modified="2021-04-07" version="1">MYMPTLPVAEARAQLSRLIDEATATHERFEITRNGRRAAVLLSADDYDMVQETIAVLSDPELLAAHEKGRAAIDGGDFLDADQLAHAMREAGRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL8</accession>
    <name>A0A7K0JPL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1638 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000172">
        <property type="protein sequence ID" value="MST31910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012437">
        <property type="entry name" value="DUF1638"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07796">
        <property type="entry name" value="DUF1638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1638" evidence="1">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17871" checksum="6E9E0EB6B5D1923E" modified="2021-04-07" version="1">SALLHDRPERIAPAVARLAGELRRDGRRVAVAYADCGTYGALDEVCRTEGLERLPGLHCYDLLAGPEAVQQLLEEEPGTYLLTDFLVGSFTRTVVAELGLDRYPELVGDYFAHYRRVVWLSEDPTPRLEAEAAAIAGRLGLPLTTLVVGRSRLERALGQLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR3</accession>
    <name>A0A7K0JPR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca(2+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cax</name>
        <name evidence="8" type="ORF">GHK86_02210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000094">
        <property type="protein sequence ID" value="MST31544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029516947" description="Ca(2+)/H(+) antiporter" evidence="6">
        <location>
            <begin position="24"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="7">
        <location>
            <begin position="36"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="7">
        <location>
            <begin position="206"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="351" mass="35538" checksum="19A2C3FEFE8AD096" modified="2021-04-07" version="1">MSTALTPTLRVSLAASAALTVGAAVAVGLGAPAAARFAVSGLALAALAAVIGETIEVVGDRTGPGITGLLQSTLGNLPELLVGIFALRQGLVEVVRATLIGSILGNALLVLGLAFLVGGLRHGTQRFDPEEPRLYGSLLLLAVGALLIPTLAHHLSIPAAHHTQALSDVAAVTLLVVYACTIPFLLRRGAAEPTPTGTAVALPLAVGALVAGSACTALVSDWFVAALEPATRALGVSQTFTGLVIVAVASNAVEHAVGVRFALRAKPAYALSTTLASPLQIALFLTPVLVLLSGAVGPTPLTLVFPALLVASLGVGTLVVVVLIYDGEYTWIEGVALLALYTIVVTAFWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS0</accession>
    <name>A0A7K0JPS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3' terminal RNA ribose 2'-O-methyltransferase Hen1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_04365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024026">
        <property type="entry name" value="3'-RNA_MeTfrase_Hen1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024740">
        <property type="entry name" value="Hen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038546">
        <property type="entry name" value="Hen1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="PTHR21404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12623">
        <property type="entry name" value="Hen1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04074">
        <property type="entry name" value="bacter_Hen1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hen1_L" evidence="8">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="9">
        <location>
            <begin position="293"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="472" mass="51770" checksum="B86A2F602FA524C3" modified="2021-04-07" version="1">MLLSISTTHAPATDLGFLLHKHPDRAHEASLPFGRARVVYPEASAARCTAALLVDVDPVGLVRGRNGGPRGRDASLEQYVNDRPYAASSFLSVALGKLFGTALSGRSKDRPDLAGEALPFEVHLPVLPCRGGEPVLHALWEPLGYEVAASGRALDDDFPEWGPSPYLDVRLSATVKTQDLLQHLYVLLPVLDDDKHYWVGDDEVDKLLRRGGEWLAGHPERDLITRRYLRHDRRLATAALARLVEADGAVDDPDAQAEARDAEEEAVERPLSLNAQRLDAVIAAVRAAGARSVIDLGCGQGTLLGRLLRDTDARLAGVDVSHRSLEVAARRLHLETMAPRQRERIELFQGALTYRDARLAGFDVATIVEVVEHLDPPRLGPFERAVWGYARPATVVVTTPNREYNRLFPTLPAGHLRHRDHRFEWTRAELATWAAGVADRHGYTVQLTGIGAEDPDAGQPTQMAVFSRAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS1</accession>
    <name>A0A7K0JPS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplS</name>
        <name evidence="6" type="ORF">GHK86_02260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4 5">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="13289" checksum="E5B2C2BB17AD1881" modified="2021-04-07" version="1">MNPTDVVDQDSLRTDIPDFAPGDSLKVHVRVVEGNRERIQVFQGSVIRRQGSGVRETFTVRKVSFGVGVERTFPVHSPVIAKIEPVTRGDVRRAKLYYLRERTGKAAKIKEKRQVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS4</accession>
    <name>A0A7K0JPS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="464"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="556" mass="58954" checksum="425014A9594A25A8" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU0</accession>
    <name>A0A7K0JPU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrolipoyllysine-residue succinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000180">
        <property type="protein sequence ID" value="MST31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="2">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25611" checksum="7F6B0EDD059D2872" modified="2021-04-07" version="1">RQGPRSTACTSVGAVGSTPPAEHMVRSKHTSAHTMVAVEVDFAGVEKVRAAHKAAFKEAEGISLTYLPFIARATVDAIAEFPHVNSSVGDDALIVHGDVHLGIAVDLDFEGLLVPVIHQADGKRLRQLAREVAGLAAKARSRRLTMDDIAGGTFTITNAGPFGTLITVPVINQPQTAILSTDGVKKRPVAIELPDGSDGIAVHPVGNLVLSFDHRAFDGAYAAAFVARIKEIIETRDWSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX2</accession>
    <name>A0A7K0JPX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000186">
        <property type="protein sequence ID" value="MST31973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9027" checksum="1D76999195FB8697" modified="2021-04-07" version="1">MISAAVVGLIIGALARLLLPGRQPIGLVATALLGLMGSIIGSFLGYHVFHIGGFTILLEIGAAVLGVALYTGRQRRTQSLGRSDKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ8</accession>
    <name>A0A7K0JPZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000198">
        <property type="protein sequence ID" value="MST32026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029559440" evidence="2">
        <location>
            <begin position="40"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="237"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="366" mass="35732" checksum="86ABEE54449B7EDC" modified="2021-04-07" version="1">MTAVGARAAVAAGAVLTLALCLVLATLGGALGASSSQGAAPLEVALTTATEGCGASGPVTGLSARQAAMAADVVAATFAVSGENRAAARIALMTADTESSLEDLGPRAGNDGSLGLFQQRATAGWGTPAEELNPAEATGMFVSRLLRVPGWAALRPWVAAQLVQRSAFTGVPSAANGGSSVVGGNYRAHWAASGAILAAVVGHGTASGCGQGVPGGVVGPVSGHGLPPGYQIPAGTGRAHATAVRFALDQLGKPYVWAAAGPAAYDCSGLTMAAWATAGVSLAHYTVDQQHEGAPVSASGLQAGDLVLTPGSDSPGPGLAGHVGIYLGYGLVESAVDPQLGVVVQAWSLFVSGGIDALVDPDPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA6</accession>
    <name>A0A7K0JQA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="32121" checksum="C365FFA53D207B77" modified="2021-04-07" version="1">MTLAGTLDLWNPTHVAGLAIGVTAFLLGMIHGITPDEHTWPITFSYAVSGYSTRRGLRTGLTFSLAFTAQRALASELASLGLARLFTFASVDNLVYLVVGALMLAAGVMVVQRHRTIHLHLRLPGRHRHHHDDDTETALHDPRWWMPAVHGFVAGWGFGAFAVIIYTVLAPAEHSLVWGWVPGALFGLGTTVVQVLAGGLFGLIAARRGLQPEAIRRVALRTAGATLTWGGVAFMAGGAIGLLFPRAVSLTVATGLHVHNLDHLGLPLVLVIVSVVGVGLTTLVRATRAEARATRTVAASAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB5</accession>
    <name>A0A7K0JQB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000220">
        <property type="protein sequence ID" value="MST32140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="17043" checksum="824F44A002DE6CD0" modified="2021-04-07" version="1" fragment="single">MSEREEAMDPTDRPPEPAAPGTAAVNRPAVFHRLVGAPSHRIFATFDRPQRATQALEELESAGRLVHDGDVWVFAQDEGIRRLDAAGTHHGVRGAVVRLVQRCMSADARYLRTLDAALRRGGVVVAVRVTGDDAGAVAAVLEAHGAHSIARVAHWDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI9</accession>
    <name>A0A7K0JQI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000236">
        <property type="protein sequence ID" value="MST32191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="18745" checksum="2078368A18471AAB" modified="2021-04-07" version="1" fragment="single">MNCSAVAVDAHLAALLREVVGDAVDDRPRRLAEYSSDASNYRVVPTAVVFPRHVDDILAVAEVCRREGVALTARGGGTSCAGNAVGPGVVLDLSRHLGRVLAVDPDARTARVEPGAVLDTLQAAAGRHGLRFGPDPSSHSRCTLGGMIGNNACGAHAMAYGTTAANVASLDLLDGRGRRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK5</accession>
    <name>A0A7K0JQK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000250">
        <property type="protein sequence ID" value="MST32230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="19168" checksum="EF0A3B082D5CE26A" modified="2021-04-07" version="1">MHVRQVRREDAEAVRAIYNREVTESTVTFDLVPRSLEDQLQWIDAHSGAHPAVVAVDDGGDVAGFASLSPYRSRPAYRTTVEDSVYVARDARGAGVGRLLLEAALQQAADHGFHAVMARIVGSHEASIRLHRACGFELVGVEREVGRKFGRWLDVALMQCLLADAGSNQRPPLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL8</accession>
    <name>A0A7K0JQL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000253">
        <property type="protein sequence ID" value="MST32245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029447017" evidence="1">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="15853" checksum="0C2ACE59C8783272" modified="2021-04-07" version="1">MKAGVVAGTAVWVAPAVESFVSPAAAASGPTTECLTGIASISWLALIIKQGGSYYIAKIDPGSSPAWGTATGKFPCGKHSFWKVPDHTYQSGAPSGVTVTATTSSAVTVNVASGYEIVTVEAHGGAGPRGGGSICVPGPSGLTGPGTFTFVPCTPTVKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR33</accession>
    <name>A0A7K0JR33_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000203">
        <property type="protein sequence ID" value="MST32064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="61"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="36097" checksum="56A2E13A8275D467" modified="2021-04-07" version="1">MAEPVTAVGEPEVHTLADDHAVVYRGACARVYEGLEPATTHDLDGVAVHTLPRPGGALLATIATVNDVHIGELECGRVHGRDDIGPILSSGPGEPPYPALMSVAAVAEMAAAAPDLVVAKGDLTSVGAREEYLGFEAIYRPAFGDRLAVTLGNHDHPASGPCFDVEPVAFHELDGVLVAVVDTTQAGQGGGAFDAERLDALDERAARADRPMLVFGHHPVADPELVALTGDGSALDQASTDALVALVARRPAIAGYFAGHTHRNRVRRFEATGAVPFAEVASTKDFPGSWAEYRVYEGGILALHHRIGDAGALGWSERCRAMFFGLYPGWALGALADRCYVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR50</accession>
    <name>A0A7K0JR50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="15"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="27671" checksum="ECF7862702F5ADED" modified="2021-04-07" version="1">LDAIEGFCRAGGGHIDDDTVAGPDSYDAALVAAGAGPDVVGRLRAGEADAAFVAVRPPGHHATPRRAMGFCLFNNVAVTAAGLAEDGERVLIVDIDAHHGNGTQEAFYRDPRVAYVSLHEWPLYPGTGWLDQRGAGEGEGTTVNVPLPSGATGDVYLSAVHDVVGPLAARFDPTWLIISAGFDGHAADPLTGLELSAGDYAAVVAELVALAPPGRVVAMLEGGYDLDALRASTTATVDALLGLRHFPEPPTKGGPGHEMVLAARRLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD1</accession>
    <name>A0A7K0JRD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000223">
        <property type="protein sequence ID" value="MST32149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="21574" checksum="47BC67A88986C6F4" modified="2021-04-07" version="1" fragment="single">MQAGGCADVVEFLFWGGVPGWSVAYQRGPLRFDPSGRPARVPGRVHLVVRLSPASGTDPVTGAAVYGGPTAMLPARPSAIRGLRRLGDFEAVTTWAVGLPSRRPFAVRVATGRLLITIAAPSPRPRRCLLRQAHLRPGYPPGWFADLTPEWACGYFGPRPFPIVPNSDAFTWTVTVRTTTLPPAAVVAAALRNGGLRRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS20</accession>
    <name>A0A7K0JS20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsT</name>
        <name evidence="9" type="ORF">GHK86_08440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000379">
        <property type="protein sequence ID" value="MST32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="10039" checksum="5E7809AC2933837C" modified="2021-04-07" version="1">MANIKSQIKRNRTNEKARLRNKAAKSEIKTRIKTAVRAAETGSETSGEDLRLAVKRLDKAVSRGIIHKNQASNRKARLMRRINQLTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE9</accession>
    <name>A0A7K0JSE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2237 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000312">
        <property type="protein sequence ID" value="MST32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="PTHR37466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11913" checksum="BD282C2E83DEF5C7" modified="2021-04-07" version="1">MTGFYRDGCCTTGPEDVGLHTICAVVTAEFLDHQRRIGNDLSTPVPLWGFPGLVPGDRWCVTAANWLRAYRDGCACFVVLASTHESTLEVVPLEVLRELAVDVPPGPDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ2</accession>
    <name>A0A7K0JSJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sigma70_r2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000325">
        <property type="protein sequence ID" value="MST32539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="10272" checksum="CBC8AFF130790377" modified="2021-04-07" version="1">MATLRRRRVPHSVAGRCPLGVMDMRSRLAEVPGPAERSVASSFETFYRQHYPPVVRLAQSVLGDFHAAQDVAQEVFLAAHQRFRGDVERAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM3</accession>
    <name>A0A7K0JSM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000334">
        <property type="protein sequence ID" value="MST32574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="373"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="547" mass="58527" checksum="459C4CBAB41C40FF" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ1</accession>
    <name>A0A7K0JSQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_07695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000339">
        <property type="protein sequence ID" value="MST32604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="18575" checksum="1B5EE52D769CE960" modified="2021-04-07" version="1">MRTSTTRDATGEEAGPGGFAGFLAGLYPDLVASLGVYASSRAVAEDIAQEALAAAWQHRGRVEALRDPRAWVYRVAINRSRSLWRRALVELAYQARLRPAAGGTGDAVEDGMAVRAAVRRLPRRQREAVGLRFFADLSVEQTAEVMGCAAGTVKALTSQAMASLRGQLDQEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS9</accession>
    <name>A0A7K0JSS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_09725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000449">
        <property type="protein sequence ID" value="MST32995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="28101" checksum="61513FC85845CB9A" modified="2021-04-07" version="1">MPSVPAALRFDAVDLDRVSTPVLRQVAFTVEVGERWAVLGPNGSGKTTLLELASGYLHPTRGTVEVLGERLGRTDVRALRPRVGLVSSSVAKMLQPGLTGTEVVMSAAHGALEPWWHRYDDRDRARARALLETAGFGHTAERPFGVLSEGERQQVLLARTLMAEPDLLLLDEPAAGLDLGGREKLVARLASLAADPGAPPIVLVTHHVEEIPGGFDHALLLRAGEVVAAGPIAEALRAETLSATFGLRLALDRSDGRWSCRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU0</accession>
    <name>A0A7K0JSU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gyrA</name>
        <name evidence="9" type="ORF">GHK86_07565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000335">
        <property type="protein sequence ID" value="MST32579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="30"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="830" mass="91250" checksum="37E1915E9825FFF7" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV6</accession>
    <name>A0A7K0JSV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000460">
        <property type="protein sequence ID" value="MST33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="117" mass="12615" checksum="6BF99828440368D3" modified="2021-04-07" version="1">MTRRIDLFIASDLPLGELAVAVAERTGLEVVPGPAGDTVSLRRGDVVVELGEHHRADGDELRLSRYRYVLSGTTDAAGHLGDVPETQLLRRSAGQLADGFDVLLVLDLQFRDPQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX2</accession>
    <name>A0A7K0JSX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_09975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000466">
        <property type="protein sequence ID" value="MST33045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029874312" evidence="7">
        <location>
            <begin position="28"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="8">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="24272" checksum="F31107F8D99994D3" modified="2021-04-07" version="1" fragment="single">MILLLVGVAGAVARPFRLPAWVTPVAAAAVALVAGAAGVGASEAALRSLASPIAFLLAAVPLSVLLDDLGFFEAAATVLTSRTRSVGGLWILAAGVTTVLNLDAAVVLLTPLYIRIARQKGLDPLTVAAMPLVLSWLASSALPVSNLTNLIAASETGATSTDFLVHLGPPSLAAVVVGWLCYRWGLRPGAMRAGGDRQLTAGDRRALAVGGGVVLAVLAGFVAGRAVGIAEWEVALAADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT64</accession>
    <name>A0A7K0JT64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">GHK86_10350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000491">
        <property type="protein sequence ID" value="MST33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="37" mass="4478" checksum="40AF4540714F5BD8" modified="2021-04-07" version="1">MKVRPSVKPICEHCKVIRRHRRVMVICTNPRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT66</accession>
    <name>A0A7K0JT66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartyl/asparaginyl beta-hydroxylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000501">
        <property type="protein sequence ID" value="MST33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018193">
        <property type="term" value="P:peptidyl-amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asp_Arg_Hydrox" evidence="1">
        <location>
            <begin position="53"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="28901" checksum="729CBB91A6638391" modified="2021-04-07" version="1">MQTTRDRAIWAANHVGARLLHGLERVVIRSSEVPTSPFLPLDTFSWIPELEGEWRTIRAELDEVLAYREELPSFQDISVDQASISDDDGWKTFFFFGYGFRSDANCRRCPRTAALLEGIPGMTTAFFSIFSPHKRLPVHRGPWRGVLRYHLALKVPEPSSAAGIRVGGEVAHWEEGRSLLFDDGYEHEAWNETDDVRVVLFADVLRPLRPPTDQVNRALIKAIGRSPYIADARNRHEAWEERFESLRGWERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM4</accession>
    <name>A0A7K0JTM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000547">
        <property type="protein sequence ID" value="MST33288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="7713" checksum="58B5C1A1ACDF8D8B" modified="2021-04-07" version="1">MTHPIPPPATRRRGHHDERGEGVISAAIAVLVMAFLGVAMWIAFSGTLSTAVKHVNNQVSCVTGATGGAASNKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR5</accession>
    <name>A0A7K0JTR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Sulfate adenylyltransferase subunit 1</fullName>
                <ecNumber evidence="12">2.7.7.4</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">ATP-sulfurylase large subunit</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="12">Sulfate adenylate transferase</fullName>
                <shortName evidence="12">SAT</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Adenylyl-sulfate kinase</fullName>
                <ecNumber evidence="13">2.7.1.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">APS kinase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">Adenosine-5'-phosphosulfate kinase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">cysN</name>
        <name evidence="13" type="synonym">cysC</name>
        <name evidence="15" type="ORF">GHK86_11485</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">APS kinase catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="12"/>
    <dbReference type="EC" id="2.7.1.25" evidence="13"/>
    <dbReference type="EMBL" id="WJHE01000564">
        <property type="protein sequence ID" value="MST33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00062">
        <property type="entry name" value="Sulf_adenylyltr_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="111"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="471"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="639" mass="68939" checksum="D7D1D93E917EF60F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS7</accession>
    <name>A0A7K0JTS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_11415</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000559">
        <property type="protein sequence ID" value="MST33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029814671" evidence="12">
        <location>
            <begin position="21"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="453"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="470"/>
            <end position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="813" mass="85576" checksum="541A2782403589A4" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU32</accession>
    <name>A0A7K0JU32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000600">
        <property type="protein sequence ID" value="MST33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="29528" checksum="1F9571125F4E657C" modified="2021-04-07" version="1">ATPVGGTATTAADPAALSPPPARPPCRGTPAPRRWRHVVWIIEENRSFAQVAGSPSAPYLARLARECGLATHYDGIAHPSLPNYLALTSGSTHGVTDDAGPAAHPIGGASIFSLLGGRWRTLAQSMPAPCDPATSGTYAVRHNPAVYYTAVRRACARQDVALGARPDLTAAFTLIIPNVCNDMHDCSTATGDAWLAHELPLLLASPAYRSGTTAVFITWDENDAGGRRVPLYVIAPSVRPGTRAAGAFDHYSLLRTTEELLGLRPLLGKAAGAPSMRAALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU58</accession>
    <name>A0A7K0JU58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyl-phosphate reductase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proA</name>
        <name evidence="2" type="ORF">GHK86_12195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000610">
        <property type="protein sequence ID" value="MST33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="7559" checksum="C3EAEE89A4B76EBE" modified="2021-04-07" version="1" fragment="single">MAPPALEELGARAVAASRAVALAPTRAKDAALAIAADLVEERADELLAANADDVARAERGEASPTVVDRLRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU74</accession>
    <name>A0A7K0JU74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_12125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000604">
        <property type="protein sequence ID" value="MST33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="745" mass="81754" checksum="6AA7516C013305C7" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA2</accession>
    <name>A0A7K0JUA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000483">
        <property type="protein sequence ID" value="MST33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="245"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="407" mass="41375" checksum="C22A5F76ED743EE6" modified="2021-04-07" version="1" fragment="single">AHMDAAAARARAALPAQGGFGPAIARIALGQVGVSDTPTSDNFGLDCDPYSTMVGPAFPNAIGCGVDARFHVVNENETWCSDFAKWVWQQAGVTAGMDRINAGSVSFYGWGRSQGERLTVDSTHPRVGDAVVFFPPGPVSASDYADHVGIVTAVNPDGTVDLVNGDFAGATTIGVQYDQHVDLSTWASQVWNPGEQWVFVAPPSGAQAPTPWAAVTGPHQAVTGTPVSFRSHAAQPGGSVASDLWTFGDGGTASGANATHVFGEPGPHTVTFTATSAAHTVTTRTWTVDVAGASSPATADPSNAVWYSATPVTQHVFRRGAGGTLMEERSNGGGWTATDLPVVLAAGTRPTALELPSTNDSLQPVVLADTTSGTVVAASPSGAGWSTTTLPGAPAAGSTVAALAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA8</accession>
    <name>A0A7K0JUA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000625">
        <property type="protein sequence ID" value="MST33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="173"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="35477" checksum="B20F60CAB5007A0F" modified="2021-04-07" version="1" fragment="single">MTTASPASAKLRAAGEVERRRGDLVDLSHRVHAEPELGFCEEKASGWVAEVLRDGGFEVDLGVCDMPTALSATYGNGALTLGICAEYDALPDIGHACGHNVIAAAAVAAGLGLAAVADDLDLTVKVLGCPAEENGGGKVLLLDRGGFAGVHAAMMVHPSPDEDPAPRTLAISDLKATFFGRAAHASGRPYDGINAADALTIAHVAVGLLRQQIRPEERVHGITTRGGEAPNIIPAETSAVYFTRAVDFEALEALEQRVRRCFEAGALATGCEVTIEPICPPYSHFEPDADLVALYLDNSRDRDRPPAKARESLGSTDMANVSLRIPAIQPMIAIEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB8</accession>
    <name>A0A7K0JUB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD+ synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000506">
        <property type="protein sequence ID" value="MST33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="277" mass="29044" checksum="1A4FC15FDBA74D76" modified="2021-04-07" version="1" fragment="single">MSRLRVALCQLDPVVGDLAGNTDAILDALARAEEAGADLAVFGELAVTGYPPEDLLLKPGFVADNVAHLAKIAAATADGGCAAIVGFVAEDLDLYNAAAVCAAGEVRGVYRKQQLPNYGVFDEQRYFGAGTGAGQLYTVGGVRVGVSVCEDLWDPAGPIAEQAAAGAELVVNINASPYHADRLAEREHLLATRAADASCPLVYVNQVGGQDELVFDGASMVVDADGRVLASLPQFEEAFAVVDLEIRPAYRKRLLDPRGRRRAPAPLPVTTVTTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC8</accession>
    <name>A0A7K0JUC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GXGXG motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000633">
        <property type="protein sequence ID" value="MST33541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXGXG" evidence="1">
        <location>
            <begin position="75"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="27792" checksum="DA48DD8E41CB3B77" modified="2021-04-07" version="1">MESVGERALTYDARGLAEPDAVAPKVAEIDGSRAVFDAAGLSTRQINLELRRLLYESGVDEVTVRNPGAKHSLGVGILRRCKLRFEGSLGYFGLGIIDGPEITVTGRVGWSVCENMMSGVVVIERNAGSLTGAAIRGGDLVIRGSVGARTGIDQKGGTILVGGNAGLLTGFMMQRGRQIICGDAGNGLGDSMYDGTIYVGGKVAGLGIDCVEAELTDADHEVLGRKLGIYGFDQPTSGFRKFVCGKKLYNYDSLEPSERKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP6</accession>
    <name>A0A7K0JUP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000687">
        <property type="protein sequence ID" value="MST33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="PTHR10605"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="27370" checksum="68776B799318A8E1" modified="2021-04-07" version="1">MGPPDVVGIGVQKAGTTWWHSLLARHPDVYAHPGIHKERHFFARFYAGGLQDADVAAYHRWFPRPPGKLTGEWTPDYLCQDWVPAQLHRAAPDAKLLVILRDPVERYRSGLQHDLEYRGRLSPASAMEAFRRGLYADDLARYEAVWGRDRLLVLQYERCRDDPANELARTLRFLGLDDTWRPDDLAARVNRTARADGVVLSEARRRDLAEAYAPDLARLATAHPELDLDRWPATQLASSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP9</accession>
    <name>A0A7K0JUP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000687">
        <property type="protein sequence ID" value="MST33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="424" mass="45937" checksum="7EBC771060F0C33B" modified="2021-04-07" version="1">MTVTEGTWIGLLTALVLFLLVTPLIARHLVRSSGDPAMFRITMWGSGIKLAAAPAYLWVIAHFYGGIADANGYFGQGARLAAQMRHGNFTLYAGKFIGDGATRISAGFVELAVGPHKLPTWFIFSFGAFLAEVMFYKAFELAVPGGARRRYAKLLFFFPSMVFWTAAPSKDCVTVLGLGLAAYGGAVLYDRRLRGFLWLGAGAALMTIIRPNVALIALLAIALPYPLGRVPARSVLTPIAAWVGGAIFIVGGVVLAGITAHHFDIHSLSRASVEKVLKQNAYNTGTAARSQLGAFNSSGATSTSLSISAIPKDFYYVVMRPLPIHAHGFTQLASSLENVYLLGLLVTSWRRLGEVIRTCLRRPYLLAALIFSLVWIVLFASIGNLGILARERTQLIPFLLVLVSVKARREPTSRPARREVLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX0</accession>
    <name>A0A7K0JUX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000700">
        <property type="protein sequence ID" value="MST33723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="27862" checksum="C1507DA71E30B870" modified="2021-04-07" version="1" fragment="single">MPPWAVAYEDAVAAAPPGRARGPWGRSGDDLLLVYTGGTTGLPKGVMWRQDDLFGVLNRSAAVRYPDDGGLDGVRERLRRPDRHPSPRQVPGPPLMHGTGLFTAIAALDSAGCVVLPPSRRFHPEELLDLVEAERVTEVSIVGDAFARPLLAALDAHPGRWDLSSLWLMVSSGVMWSAEVKAGLLRHAPRLTMVDTLGSSEAVGIASSRSDGQRGTVATAGFQLGPHTRVVDEDGRDVAPGSGRPGLLALRGRGPVGYYKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ9</accession>
    <name>A0A7K0JUZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_11445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000561">
        <property type="protein sequence ID" value="MST33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="29776" checksum="73F0CBBBA2AA4283" modified="2021-04-07" version="1">MLAEGRTYSFEFFPPKTDEGRRHLARALVELQPLEPSFVSVTYRGGPSSREPTHDLVAGMLKTTTLNPMAHVTCVGHTRLELADILVQLRKAGIDNLMALGGDPPAPGVPQGELRYAQELVELARAIGGFSIGVAAHPSVHPRAASREADRAHLAAKLRLADFAVTQSVFSVREYVSLVEDLAALGVDKPVLPGIMPITALSSIDRQRELGAVVPDDVEARLRAARREADVRAVGIELATELCAALLDAGAPGLHFITLNRSSATREIYGNLGIVASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV13</accession>
    <name>A0A7K0JV13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000733">
        <property type="protein sequence ID" value="MST33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="16517" checksum="470E8C08FD2D4274" modified="2021-04-07" version="1">TTDRVRRLQAAEATAGPSAGPVGTRSQAAWITERVFPGASASLLRPPGRARWKSPLRYGRLSAGLDASYAVTTSGRLRRVTDWVPLAKVQSVRYVQGPVQRRLGLASIHLDTAGRSVFAVLRDRDEREAAAWFATLPDACRLARAEAPPTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV29</accession>
    <name>A0A7K0JV29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000739">
        <property type="protein sequence ID" value="MST33827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="17508" checksum="38145C168C1F1749" modified="2021-04-07" version="1">YSSDHRPTGRLLLVLPVLGMAAVGLIAIGYPYVLGNGRDLAQLAMTGSVGLVGLVALSLLKPVATNLTLGSGVSGGLFTPTFSFGAVLGAFLGHAWARLWPAGDPASFAVVGAAAMLSAGMQAPVAAIAFALELTGSSDRIMVAMLVAAAGAVLTCRRFEQRSVYSARLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV39</accession>
    <name>A0A7K0JV39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000741">
        <property type="protein sequence ID" value="MST33837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="17464" checksum="6F7716D4005FDA2A" modified="2021-04-07" version="1" fragment="single">MIGPRPAAVPAGDGAGRQGRRRRGAASDRLDAVDEAIVRHLQDDGRRPFREIARSLGVSEATVRARVRRLTDADALRIVAIADPFRLGFRVLAFVLLKLEPGRRRQVIETLTPWPEVTYISSLTGRADLYIQIVCHSHEDLWELLSERLPAIPGIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE7</accession>
    <name>A0A7K0JVE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Decarboxylating 6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gnd</name>
        <name evidence="6" type="ORF">GHK86_12205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000610">
        <property type="protein sequence ID" value="MST33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="339" mass="36075" checksum="F05B88BD5A835EFA" modified="2021-04-07" version="1">MQLGMVGLGRMGANMVRRLTRAGHTCVVYDVNPDAVKSLEAEGATGAASLEDFAAKLDTPRAAWVMVPAAFTGETIDQLAAVFEAGDIIIDGGNSYYQDDIRRAAALRERGLHFVDCGTSGGVFGLERGYCLMIGGEDDTVRHLDPIFKSIAPGFDAAPRTPDSRGEPSTAEQGYLHCGPNGAGHFVKMVHNGIEYGIMAAYAEGLNVLHKANVGAEHAGGGDAETAPLDHPEYYRYDLDTAEIAEVWRRGSVISSWLLDLTAHALRQDPALGGFAGRVSDSGEGRWTIHAAVDVGAPAHVLTAALYERFSSRGEADFADKLLSAMRKEFGGHDEKPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF8</accession>
    <name>A0A7K0JVF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YggS family pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_14520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000774">
        <property type="protein sequence ID" value="MST33928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="23482" checksum="2840C219E8D94CA5" modified="2021-04-07" version="1">MDERPAPPPVDPDAVIERLEEVRARIAAVGDPDRVRIVAVTKGFGPDAVAAAVAAGLADCGENYAQELLAKAAGAPAGTRWHFLGAPQRNKIASLAPVVHLWQAVDRRAVVDRLAAVAPGAALLVQVDVVGDPGKAGCPPEEAPGLVEAARAAGLRVRGLMAVGAAGDPEGTRGVFEALARLGRSLDVEELSMGMTDDFEAAVAAGSTMVRLGRVLFGPRPGRAAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG0</accession>
    <name>A0A7K0JVG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000781">
        <property type="protein sequence ID" value="MST33940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9424" checksum="818F8DA92A6E4967" modified="2021-04-07" version="1" fragment="single">MTAGGDGAAPLGDRLCLAVDLGTGGPKVGLVTLDGRLVRWEHVPVETSWLGDGGAEQDAAGWWEVIRDPATWRTSGSPLEGDPARTRDPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS7</accession>
    <name>A0A7K0JVS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_15175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000829">
        <property type="protein sequence ID" value="MST34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="20607" checksum="0F3CC6C40218D4F9" modified="2021-04-07" version="1" fragment="single">MNERIRAREVRLIDPDGGQLGVKPLPEALSIARSMDLDLVEVAPDASPPVCRIMDFNRYKYESAQRAKESRRKTTSTSIKEMKYRPKIGTGDFDTKTRQVAKFLGEGHKVKITIMFRGREMSHPELGKKILDHVAETVGPVAKVEAEPKLDGRNMTMVLAPDRRAQQAGRVEGRRPEAAGDGAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS9</accession>
    <name>A0A7K0JVS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000825">
        <property type="protein sequence ID" value="MST34051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="12555" checksum="C0F3704FB500BDAA" modified="2021-04-07" version="1" fragment="single">MDARVKVAVIGGGVAGCSVAYHLGRLGCPDVAVLEADELTSGSTWHAAGLCTQYHSSLQLMKLLRTSVELYDGGLAADTGADVGYHRCGSLRLASTPARVDELHARRAMAESVGIPFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW4</accession>
    <name>A0A7K0JVW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000850">
        <property type="protein sequence ID" value="MST34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8689" checksum="62961F8272BBA811" modified="2021-04-07" version="1">MSVGTYRVPATGTDDQDPHAEDELYVVMAGRGRLTAGGETVAVVPGDVVFVPAGEVHRFHDVTEDLSLLVVFAPAYSGDGGDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY2</accession>
    <name>A0A7K0JVY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">moaA</name>
        <name evidence="14" type="ORF">GHK86_15430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="WJHE01000853">
        <property type="protein sequence ID" value="MST34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="251"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="34342" checksum="0FE7D297E490BA29" modified="2021-04-07" version="1">MRDLRLSITDRCNFRCTYCMPQEGMQWLPRAELLSFEEMERIVGVLVDRYGFESVRLTGGEPTVRAHLPVLIRRLAALGVELSMTTNGATLGLVAADLAEAGLGRVNVSLDSLRADRFAAITGRDSLHRVLDGIDAALAAGLAPVKVNCVLVRGVNDDEILDFAELGRRSGAEVRFIEWMPLDGDGAWAGDRVVPAAEVLKVLAGRYELEAVGGGAIDGPAPAERYRYADGGGHVGVIASVTRPFCGTCDRIRLTAEGQLRNCLFSVRETDLRGILRSGGSDDDLATAIEAEVGRKWAGHSIGQVHFIRPARSMSQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY6</accession>
    <name>A0A7K0JVY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000858">
        <property type="protein sequence ID" value="MST34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="15357" checksum="B2AC51DE3844FD46" modified="2021-04-07" version="1">RRSQWPQIVEARLREVRLWDALKDRLKESPFRLSGGQQQLLCLARALAVGPDVLLLDEPTSALDPISMQAIEDLLRDLTPALTMVIVTHNLAQARRLSDYTMFFNQGHLVEFGETGRVFEDPDAEETAHYVSGRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW32</accession>
    <name>A0A7K0JW32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000876">
        <property type="protein sequence ID" value="MST34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HisKA_3" evidence="1">
        <location>
            <begin position="263"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="442" mass="46681" checksum="4D13689CFE4ABA02" modified="2021-04-07" version="1" fragment="single">MGGAGGVSAEVRSGGVAAADRIAPWRRGAVDPRFWLVQGLVVAIFVANEVLTGPSGSSAAGRVTDLAVEALFLAPILYAALNFGVPGSLATAAGVSLLVIGGDLSVDLVNRRLADAGSDVVMLVLLDAVALFVAWRVSVEHDARSRYFSLFEIDAQPVFLLDASDRVLELNAAARHLLSARPAPAAGRPLASVLGVAAGELTDGATVSVPSAPGEYRLVTRRLAGRSGAARQQVVLEEVDAQRRKEREARIFARQLLRAQEEERRRVAQEIHDGPVQRLVQLCRQLDVVDETPGLPDGARNGLADSRAVAELAVEELRDLLRGLRPPALEHLGLVPTLRRLVEAMPARSGIRSHLIVDGRERRLGAEVELAAFRIGQEALTNVERHAGATSVTVTCRFRAAVLELVVADDGRGLVGDPRWAEGWGGVRGPGAAEGPGGEGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW35</accession>
    <name>A0A7K0JW35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Decaprenyl-phosphate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.45" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000880">
        <property type="protein sequence ID" value="MST34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="293" mass="31188" checksum="982FDA3D94AFA891" modified="2021-04-07" version="1">MSRIRALVAAARPRQWTKNVLVFAAPCAAGVLDHASPALRALAAFALFCVVASGSYFVNDALDAEADRAHPVKRHRPVASGAIPVPAAIAVGAALEAVGVVLAALIDWQLAVTMLVYVAVQIAYNIWLKHLPVWDLVCVASGFVLRAIAGGVAVAVPVSQWFLIVATFGSLLMVTGKRLAELLELGDGGGAHRRTLSEYSATFLQTILAISAGGAMIGYALWAFDLRTALRHHSAPIWFELSIVPVLIALLRYTFLVEQGQGARPERLVLGDRSLQLLGLAWVVLLGIGVYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW99</accession>
    <name>A0A7K0JW99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000903">
        <property type="protein sequence ID" value="MST34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="32988" checksum="32A5F1E46D8F3A24" modified="2021-04-07" version="1">MSARSRTLPRRSCHAVPGSSERFLEKAPGLGADEVFLDLEDAVAPAEKVAARSRVAAAVRSADWGDAVVCVRVNAWDSPWTVGDLLEAVAPAGQRLDTVMLPKVERAAEVVALDLVLTQLERTVGLPVGHLGIEAQIETARGLIEAEAIAAASPRVEALILGPVDMSASMGMPSLAGGLDIPAYPGDYFHYVLVKILMAGRAAGVQVVDGPYVKVRDLDGLRAYATRAQTLGYDGKWSLHPDQVPVLNEVFSPSPAQFERACTILDAYARATEGDGRGAVMLGDEMIDEASRKVALALVARGERAGLRRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB0</accession>
    <name>A0A7K0JWB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GHK86_16025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000901">
        <property type="protein sequence ID" value="MST34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="11330" checksum="D5009ED933BFC16C" modified="2021-04-07" version="1">MTDIWSLSLLVAADEDRSWQRQANCMGVDPDLFFPERGASTREAKEVCRGCVVREDCLEYAIVHSEKFGIWGGLSERERRRIRRSRALERTSGPAVGGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE4</accession>
    <name>A0A7K0JWE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000894">
        <property type="protein sequence ID" value="MST34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="9130" checksum="96582B4EA037435C" modified="2021-04-07" version="1">MTTVREAASPTGSRQQRRNQRRRLVREQALAVVVLVALFLVTVLLLGLQWLHAGPTGTHRGAGTLPTPLAEVSWMRFAVMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG0</accession>
    <name>A0A7K0JWG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000923">
        <property type="protein sequence ID" value="MST34273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="560" mass="57689" checksum="93740157D3624D81" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS7</accession>
    <name>A0A7K0JWS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000983">
        <property type="protein sequence ID" value="MST34398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="211"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="623" mass="67609" checksum="F5A4AC898AC87FD1" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU1</accession>
    <name>A0A7K0JWU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000997">
        <property type="protein sequence ID" value="MST34421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="18654" checksum="18356B02CC0342EF" modified="2021-04-07" version="1" fragment="single">MPLPALVVVTDGSLTGGRPLPEVVAAAVDGGARAVLLREKHLPRPERRALAAGLSTLLRPVGGILLVASDPAIPSDGVHLASGDAVPDPPPPRWGRSCHMAADVVAAAAQGCHYATLSPVFITTSKPGYGPPLGPPALAGHPLPVWALGGVDDANAGACLRAGAAGVAVMGFVMRAADPAAATAALCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ8</accession>
    <name>A0A7K0JWZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001025">
        <property type="protein sequence ID" value="MST34475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="32228" checksum="DB9B64A35FF339C3" modified="2021-04-07" version="1" fragment="single">MNSMPEPAADGSGLVSMRTIGAAFRRHRRILVACVVVGTLVGGAVHLVVPRRVSASEDLYLAQPPGTDTAVEVANDQSLLQTWAVADGAVRALHLDMTPTNFLKTYRSKAVSTAVVSLTLSAPTAQDAVTREEVLARTFLAFRAARYSQQVDAEVANLRVQATTLQREIAQLSASVPTSSTNGASAGRIARALNRESSDTSALASVDSQMQQAQLGLRALVGGSEILDPAVATIPSPARVWAEDALAGLAGGLGLGLLGVLVAASLSDGLLWRDDVAAVLDAPVGASVGTSASRFLGRRAARARRRRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX63</accession>
    <name>A0A7K0JX63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MsnO8 family LLM class oxidoreductase</fullName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001062">
        <property type="protein sequence ID" value="MST34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029442670" evidence="2">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="30527" checksum="812843CA074F0B6F" modified="2021-04-07" version="1" fragment="single">MTLRRAVPLSVLDLAPVPAGATAIEALARSTELARRAEAWGFRRYWVAEHHNMPGIASSSPAVLLAHLAAATRTMRVGSGGVMLPNHAPLVVAEQFGTLASLHPGRIDLGLGRAPGTDPATASALRRSAAGLSADDFPEQLGLLLAFLEGDLPADHPYARIQAVPRAPEPPAIWLLGSSGYSAQVAGMLGLPFAFAHHFSPANTLPALELYRSRFRPSEILQEPYALVGAAVVCADTDEEARWLHGSMRLSMLQLRTGRPGPLPSPEDAAAYAYTPDEERIIEAATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA1</accession>
    <name>A0A7K0JXA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001080">
        <property type="protein sequence ID" value="MST34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="235" mass="23975" checksum="6A8D7F9DAC491F6F" modified="2021-04-07" version="1" fragment="single">LDGALAVVTGAGSGIGRATALALAGRGARVLAVDLDEGRAEETASACGGWAARLDVTAREAVDAFVATTLERHGTPDVLVNNAGAGMTGRFLDMQLADWDWIVGTNLLGAVQLTRAFGPGLLARRSGHVVNVASGLAYVPRATEPGYVTTKAAVLAWSQCLRADWHAAGVGVSVVCPGVTDTAIVRANTRYLGGRADPSVRARIEAAFARGAPPGLVAAAVVDAIERDRSVVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE9</accession>
    <name>A0A7K0JXE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaB</name>
        <name evidence="10" type="ORF">GHK86_15955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000897">
        <property type="protein sequence ID" value="MST34209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="32582" checksum="2FE5A6238629D52D" modified="2021-04-07" version="1">GAPADVGLAEQPGESVDHEPAPRQRSRAAAYLALTKPRIIELLLITTVPTMLAADRGVPSLALIAATVAGGTLAAGGANAANMIYDRDIDAVMTRTRHRPLVTGEIRPASAVAFVVALEVIAFAALWAAANLLSAVLAVGAAAFYVFVYTMWLKRRSPSNIVIGGAAGAVPVLVGWAAVTGTVAPAPLLLFALIFLWTPPHFWALAVRYSRDYARAEVPMLPTVATPSATARRIVAYAVATAAVGVAAGVVAHLGWVFGAVATVLGAAFVGYALAFRRSPQGRRALHLFHFSITYLTLYFVAMAVVVVVAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI1</accession>
    <name>A0A7K0JXI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001134">
        <property type="protein sequence ID" value="MST34663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="297" mass="31806" checksum="2A715DD5E397C333" modified="2021-04-07" version="1">MGWSAEDIPDQSGRRIVVTGANSGLGRVTATELARHGAAVTLAVRDEAKGREAAAAMPGSVEVRRLDLADLASVRAFAEAWEGTLDVLIDNAGVMLTPERRTKDGFELQFGTNHLGHFALTNLLLPKLTDRVVVVSSAAHRMGRIDLDDPNWERRRYRSWGAYGQSKLANLLFVWELQRRLDEVGSPLRAVAAHPGYAATNLQTRMANPVANGVSALATRLLAQSAADGALPTLYAATQELPGRTYIGPGGFMEQRGAPKVVGRAAAASDDGTARRLWELSERLTGIEFPLTSGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ1</accession>
    <name>A0A7K0JXQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001180">
        <property type="protein sequence ID" value="MST34733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="22108" checksum="98365454F8DE52C5" modified="2021-04-07" version="1">MIRVLVVDDHPVVRSGLVGLLGLEPDVVVVGEAADGAEALRLAAERAPDVVLMDLRMPVMDGVAATDRLAGTVPAPRVLVLTTYDTDSDIVRAVEAGATGYLLKDTPREALVDAVRRAARGETVLAPPVAARLLQRVRRRDLELTPRELEVLTEVGRGLSNAEIGIKLLVGEATVKTHLLHVFAKLGVSDRTAAVTVAISRGLLPTSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY69</accession>
    <name>A0A7K0JY69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001294">
        <property type="protein sequence ID" value="MST34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="3">
        <location>
            <begin position="37"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="477" mass="52161" checksum="6C85449AF1F233C8" modified="2021-04-07" version="1" fragment="single">VAAAERFPTVVMPLVAARLRAELAGYVLAAEPWRLRRHLARRRAEGIRLNLNLLGEAILGDEEADRRLEGVLRLLRRPDVDYVSVKVTSVSAQINHADFDREVERIAGRLRRLYDVALAGRPAKFVNLDMEEYRDLELTVAVFRSVLSEPAYRGLDAGIVLQAYIPDSLPVLRELISWARDRRAAGGGRVKVRIVKGANLAMERVEAELAGWEQAPFATKAEVDANYKRMLDVALEPSNADALRIGAASHNLFELAWALTVAAERRVPGMLEVEMLEGMAGSAAHPVRDAAGGLLLYAPIVARADHESAIAYLVRRFDENTAPDNFLRNQFAMRVGSPAWGAEQRRFAASVTERERPTVATRRTQDRTRPGPGPTTPDGFANEPDTDLTRPANRAWLAAHLGGPDWGPEHVVPAVVDGAVVDAPAAGRGVDPSEPGRTIYRWVQAPRELVDRAVAAAVAGQEAWASTPGAARAKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY79</accession>
    <name>A0A7K0JY79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4157 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001300">
        <property type="protein sequence ID" value="MST34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="111" mass="11236" checksum="06C3B5D61E7DC638" modified="2021-04-07" version="1">RAAVPEVGRAGGGLDAGTESAIASARRSGGAPLPDRSRSRFEAAFGGADLSGVRLHTGPAASELNERVSARAFTIGRDVFFHGSTPDLGSAAGQELLAHELTHTIQQTGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB9</accession>
    <name>A0A7K0JYB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Segregation/condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001325">
        <property type="protein sequence ID" value="MST34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="29418" checksum="1EB4C87418E9A3E2" modified="2021-04-07" version="1">MPYTVSTPVFEGPFDLLLHLITREQVDLWEVSLSAIVDEYVAALEALRADLDLETATEFLLIAAVLLELKARRLLPGEDDADLDEELALWEERDLLLARLLECKTFKDAAGALTRMMDGAARSWPRTAGLEDRFVGLAPDPLEGVTAERLRNALRAALAPKPVPRVTLDHVGVIRVTVADAVAELVDELPRVGRISFRRLTAGLVERIEVIVRFLAVLELCKQGQVELDQAGSFEELHVRWLDDDERERTDGVRLEEIEEYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG6</accession>
    <name>A0A7K0JYG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_19615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001304">
        <property type="protein sequence ID" value="MST34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Tricorn_C1" evidence="7">
        <location>
            <begin position="88"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Tricorn_PDZ" evidence="8">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="214" mass="22935" checksum="F68B1EE07256D5E6" modified="2021-04-07" version="1" fragment="single">GNLGQGRAQPGGEAAKARLEHLDLATGKLTTLADAVDAVAVTAEGRALVVRKDVALTIVPADRPAGDDPAAKLELDLSRVLVTVEPAAEHVQMYEETARLLRHHYWVEDMAGIDWDAVVARYRPLAERVATRDELHDLIWELNGELGTSHAYVFHHDDQPTAQQRVGHLGADLEPADGGWRVAAVPHAEPSVPGARSPLEPAGVTVGDVIESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH4</accession>
    <name>A0A7K0JYH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001351">
        <property type="protein sequence ID" value="MST35000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="14643" checksum="8F6026DCB87D0951" modified="2021-04-07" version="1" fragment="single">MTPVLELRGVTRVFGHGETAVHALRDVDLAVTAGELVAVMGTSGSGKSTLLHLAGGLDTATAGDVVVEGRRLADLGAAGVAALRRRAIGYVFQQFNLVPSLSALENVMLPLELDGVALRTARSQASVALADVGLGGLERRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL3</accession>
    <name>A0A7K0JYL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_20265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001386">
        <property type="protein sequence ID" value="MST35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="19940" checksum="8D0C2374A06A548B" modified="2021-04-07" version="1" fragment="single">AAPLLALGRPLTMAAQATGRPLQRRVVRLANSRVLHAVTHPVPTTAVYYGTMYAFFLSPLYAYAVTHQLVHDATHLVFLAAGYLYWQPLVGGDPGRSRRSHMGRIATLLVGSPFEGVLGVVLSGASWSISPVNTVAQTQAGGQVFLAMSMLASGLWALWLGWDWLADATRTAGRDDRRAALAVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR9</accession>
    <name>A0A7K0JYR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001151">
        <property type="protein sequence ID" value="MST34689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaA_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="11140" checksum="7663756E90C9A90A" modified="2021-04-07" version="1" fragment="single">MSTAQELWTSCTQHLRGQVTDGTWQPWFSGIRPLDYDGGTLLLAVPSSVVRSRLEERYLPLIEGSASDAAGRPIRVQLRVDPRAPAEEAGTAHVGAPAPGGAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ18</accession>
    <name>A0A7K0JZ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001500">
        <property type="protein sequence ID" value="MST35186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20106" checksum="18E90AD6CF9785E6" modified="2021-04-07" version="1" fragment="single">VGAGGLQVRSPEAAAADLGHWGSFGGPIDLAGDQRPNDGQALCFDLPVATEAVELLGFPHARLRVAADRRAAIVAARLCDVAPDGTSRLVTLGFLDLTHRHGHDRVEALHPGEPCSVDVALNAVAYRLPAGHRWRLAVSSTYWPWIWPVPEPATLTLHPGSSLELPVLDPGTPTHAPPPHFAEPEHAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ81</accession>
    <name>A0A7K0JZ81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001269">
        <property type="protein sequence ID" value="MST34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="80" mass="8911" checksum="F9850D3053CB5BB9" modified="2021-04-07" version="1" fragment="single">MSLTLDQSATRCGGHCWIERRLFEVLGAWGAAAGAPRVVILLDRHSQHAAWRAGQWWERLPVRAGLDREGLVQPPPGWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ88</accession>
    <name>A0A7K0JZ88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001516">
        <property type="protein sequence ID" value="MST35202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="15673" checksum="5F16291C559D8D66" modified="2021-04-07" version="1" fragment="single">MDIEVVIEIPKGTRNKYEADENGVLWLDRMLFTATSYPEDYGYVPGTLAADGDPLDAMVLLDEPTFPGCHVLARPIGMFLMRDEEGVDAKILCVAAHDPRRAAVTELEHIPSHELDEIAHFFTIYKALEPGKKSEISGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE8</accession>
    <name>A0A7K0JZE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3054 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001318">
        <property type="protein sequence ID" value="MST34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021414">
        <property type="entry name" value="DUF3054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11255">
        <property type="entry name" value="DUF3054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8002" checksum="AFA928F5F85B23A2" modified="2021-04-07" version="1">GRLAVGRRSGLRWAPETLRAGVAITVVTVAVGMVLRVIAGQGTAVPFVAVSLGFIGAFVLAGRGLLVAVTRRRLAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF6</accession>
    <name>A0A7K0JZF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001641">
        <property type="protein sequence ID" value="MST35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="29011" checksum="ABB1DB4227832405" modified="2021-04-07" version="1" fragment="single">MNEQDFDTRRTLAAIRRAKRMVVAVGIAGLACGVGLAVARPGPDQATAIVLLPGVLSQTPGSTTPDVQTQVVLAESTPVLSAALAQTHVRMSTRTLGKHLQVTSSSPELLRVTVQSRSGTEAERLANAVAAGYVDYVTSTGTGSGSAGLSSEVSQLNGQLASLHNEMARLSATLRSTSLSAATRAQDTAALATLENERASLSLQIDSLNSQIAQARLNTILSSGSVRVLQQAATYVDTAPIRLALFGGAGLVLGLVLGSGAAILRAGRRRRLYSRAELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG1</accession>
    <name>A0A7K0JZG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fabI</name>
        <name evidence="12" type="ORF">GHK86_19850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01001332">
        <property type="protein sequence ID" value="MST34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="259" mass="27286" checksum="FAE23C59ECA10DA3" modified="2021-04-07" version="1">MSGLLAGKRVLVTGVLTDDSLAYGVARVAQEQGAEVLLTSFGRAMSLTRRVAKRLAGPPEVLELDATDPGTVDGVGAWIAERWDGRLDGILHSIGFAPASCLGGGFLEAPWEDVAQALQVSAFSLKTLTAGLLGPLRAAGGGSVVALDFDNRVAWPGYDWMGVAKSALESTARYLARDLGADNVRVNLVAAGPIRTVAARSIPGFSRFEDVWDERSPLGWSVTDPEPVARACVALLSDWFPKTTGELLHVDGGYHAMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZP3</accession>
    <name>A0A7K0JZP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3151 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001663">
        <property type="protein sequence ID" value="MST35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014487">
        <property type="entry name" value="DUF3151"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11349">
        <property type="entry name" value="DUF3151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="9326" checksum="94F922181D5B50AB" modified="2021-04-07" version="1">DPVASYAYARVGYHRGLDALRANGWRGNGYVRWRHPSNRGFLRSLEALRAAAGRIGEDAEETRCRLFLLQLDPDWERRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZP4</accession>
    <name>A0A7K0JZP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001383">
        <property type="protein sequence ID" value="MST35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17715" checksum="966B83D58C60FCC4" modified="2021-04-07" version="1" fragment="single">MLDVVVIDTPTLGDRSYLVHDGTIAAVVDPQRDLDRVLAAAAGAGVQIADVVETHIHNDYVSGGRALAEACGARYHVNVADDVAFRRHAVHPGERIQVSATLALRAVAAPGHTHTHLAYVLEERGAPVAVFTGGSLLYGSTGRTDLLGPEHTLELAHAQWATAHRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZU0</accession>
    <name>A0A7K0JZU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001417">
        <property type="protein sequence ID" value="MST35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15612" checksum="27FC3698E9C01A65" modified="2021-04-07" version="1" fragment="single">MPLDRNGLEILPRDACLELLRSRTIGRVGLTRDALPTILPVNYRLVDEQIVYATGTGSKSLAALHEQVVAFEVDDADSTRREGWSVVVVGIPRELDDGDGHAARAVAMGLRPWIGERAPYLFRLGTERLSGRRVAVRPAASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZW5</accession>
    <name>A0A7K0JZW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4349 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001438">
        <property type="protein sequence ID" value="MST35109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="22289" checksum="6EB6699AAA375B2F" modified="2021-04-07" version="1">ALTVRVGKAAAVAAGASTVEALAARDGGYVQASSVGSGPHPTASLTVRVPDPRLPAAMASVAALGSVRHRSQSGVDVTGQVVDLAAEQLNLQNEEGAVRKILDRATKVSDVLTIQQELFALQGEIQQLQAQRNSLANQVAYADLAVTLVAAPVAAARPPQPGVLARFWHLAAGHTVATVRGFVLAVGWAFPGLVAVLVAGGLYLAARWLRRRSQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0B5</accession>
    <name>A0A7K0K0B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001548">
        <property type="protein sequence ID" value="MST35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="32002" checksum="244F96FE44177044" modified="2021-04-07" version="1">ARRVDTAGALLGAGALTAAVFAVIEGESAGYASAGVVVLFAVAAVGLAAFVRRERRAAHPLLDLRYLRRPAFSSANVAAFCTYFATFAIFFFTALYLDEVVGDSAFRIAGTFLPMTVLLVVAAVTAGRLTLRVPTGRLVGTGCLLFAAGLLATAALLSPDPSEAALTVALAVAGAGIGLTVVPITGSALAAVPAARSGMAASAANTSREVGAVTGVAVLGALVNGELQSHLGARLRALGLPPDLQSLVIRGVESGGLPSNGHTTGAGGAAGAGHAGEVHEVIAAAWAAFGSGLEVALLVSAALVLLAGALAAFTLRGRPGADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0L7</accession>
    <name>A0A7K0K0L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001625">
        <property type="protein sequence ID" value="MST35324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-oxidase_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8611" checksum="98689C1A35B3DE4C" modified="2021-04-07" version="1">PAARVAAEAYYRAAWDAVTDATLTRGGALSHHHGVGLNRGRYLAGALGSGFAVLEALKATLDPHGILNPGKLGLASPFGPPPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMJ6</accession>
    <name>A0A7K0JMJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroK</name>
        <name evidence="3" type="ORF">GHK86_00345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="17312" checksum="C8A51A832A9AADEC" modified="2021-04-07" version="1">MMGAGKSTTGSLLAQRLGAAYLDSDAEILRRTGRTVPEIWHQDGEPAFRAEEARVLADALHRHGPTVVGVAGGAVLDPVNRELIRRAGTVVWLRARPETLARRVGAGEGRPLLEGDPAANIARLDAERRPVYAELAGVVVDVDELSPPEVVDRIVTAAGLATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMN9</accession>
    <name>A0A7K0JMN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000016">
        <property type="protein sequence ID" value="MST31195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="8458" checksum="323B47A38BB93E71" modified="2021-04-07" version="1">MSTPDTGDLPANPRGNWFYCFKHGKVETREECDRGDRLGPYETREAAEHWRDRVAARNEQWDEEDEEDDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMP1</accession>
    <name>A0A7K0JMP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000005">
        <property type="protein sequence ID" value="MST31137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="8325" checksum="915340423D2FBDB8" modified="2021-04-07" version="1" fragment="single">MARPVGDVVGDLQEAVRAGAELVGRGRSAWDADRVHRLAGEAIISRVGEAVVQLPEEVRAAMPAVPWREWRAQRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMR7</accession>
    <name>A0A7K0JMR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="18710" checksum="8D06FEBD0FB7CA5E" modified="2021-04-07" version="1">MLTAQRAGADPRPGDEAGFTLVELLVTALVAVITLAIAGGALESMTTASNRATGAATSMSAVSLAVSRLSSDLRSTHALTVASATSFTATVNQADGTTATVVWSITGGDLTRTAGGGSPETFLTGLASGSGFAYDTPSGTPAAPSCTSRVVVDLIEPTGQTAVTPYQEHVSIAVTDQAMNIAEGNVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMS0</accession>
    <name>A0A7K0JMS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000007">
        <property type="protein sequence ID" value="MST31151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="16741" checksum="851054FF24FB5120" modified="2021-04-07" version="1" fragment="single">QMTNYAVLLQVFLLTHRSLAVGLVGLAIAAPTIVVSLGAGPWIDRIDRRRTVLTCTGIQVGVSAALAVQAFAHLDRLWLLYLLVAVQASVGGVSAPARRTFMPMLLPKDQLAAGAALQMLTMHGSATIGPALAGLLTAAAGLRVCYVVDAVSFAFALYGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMT2</accession>
    <name>A0A7K0JMT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 127 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000028">
        <property type="protein sequence ID" value="MST31276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="582" mass="63084" checksum="44DF999AF6F9261E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV1</accession>
    <name>A0A7K0JMV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_00560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000021">
        <property type="protein sequence ID" value="MST31223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="58"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="206"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST31223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="32407" checksum="D6F2BC4026C7BF66" modified="2021-04-07" version="1">MTLSSRYLLRETGDNLRRNLVMTVAAVVTMVVSLAAAGGVLIMREAIHKQAIQWRGGVQVAVFLNASVSQSEVHAVGQLLAQDRPGNGGGPGLVKRYFYVDKAEAYREFRTIFGGDPALVRALGPAQMPPSYRVVPLKPGDVTSIGDQFQSQPGVFRVTYARQAIQALENRFHTLSEIAVALAIGVMVGAVALIVNTIQLAIFARRREVAVMKLVGATNWFIRIPFMLEGLVDGVLGALLAFVPIYFARGSIASFVGSESLIAQPLYVTPHDAVMTGLVMLLVGAAVGALGSAFAVRRFLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN21</accession>
    <name>A0A7K0JN21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000029">
        <property type="protein sequence ID" value="MST31277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="11473" checksum="401107ED02D15C99" modified="2021-04-07" version="1" fragment="single">MTAGACGTTGTPTGAPSGKPVVGGTATFAEAPGSPPNYIFPLDALQYFNTTDINQFQNLMWRPLYFFGQGDNVVLNQQLSLAEPPVYSNGDRKVTIHLKAVHWSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN78</accession>
    <name>A0A7K0JN78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydropyrimidinase</fullName>
            <ecNumber evidence="4">3.5.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hydA</name>
        <name evidence="4" type="ORF">GHK86_01615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="56"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="470" mass="50587" checksum="CA8E07909DF5780B" modified="2021-04-07" version="1">MTILITGGTVVSPTGASAVEVLIDGERIAALLEPGSSAAESLAGNADQVIDAAGRYVIPGGVDGHTHMEMPFGGTTASDTFETGTRAAAWGGTTTIVDFIVHRAGEPLLDGIGAWHDKADGRCAIDYGFHQIVSAVDSDVLKGMDALMNEGVTSFKLFMGYPGVFYSDDGQILRAMQTASDSGALIMMHAENGIAIDVLVEQALARGETAPGYHGTTRPWETEAEATYRAIMLARIAHAPLYVVHMSAKQAVANLAEARRAGWNVFGETCPQYLYLSLEEHLFADGFDGAKYVCSTPLRARAEGHQDELWRYLRTDDLSVVSTDHCPFCLKEQKELGIGNFSKIPNGIGSVEHRMDLIYQGVVDGHISLPRWVELCSTTPARLFGMYPRKGILAPGSDADVVIYDPAGRTRISVETHHMQLDYSAYEGTEIAGHVDTVISRGQVIVDAGRYLGRAGHGRFVKRGLPDCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE2</accession>
    <name>A0A7K0JNE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000081">
        <property type="protein sequence ID" value="MST31492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="466" mass="50825" checksum="B61C083A6D88435F" modified="2021-04-07" version="1">MTSRAATLGQLRDSGWRSLPVKEEVRRNAARRIAAGQPLVESVLGYEHTVLPQVENALLAGHDIIFLGERGQAKTRMIRSLTGLLDEWLPIVAGSEILDDPYHPVSRHARDLVAEKGEDTPIEWVHRDTRFGEKLATPDTSIADLIGEVDPIKVAEGRYLSDELTLHYGLVPRTNRGIFAINELPDLAERIQVGLLNVLEERDVQVRGYKIRLPLDVMLVASANPEDYTNRGRIITPLKDRFGAQIRTHYPLDVDTEIAVVHQEARPLDDIGVRVEMPAYMAEVVATLSHLARQSPQVNQRSGVSVRLSVANYETLAASAARRALRLGEHEAVPRVSDLEGLAASTAGKIEIESMDEGRDGVLVERMLSQAVLTVFRARVPMDTLREAIGAFDGGIVAHAGDDLSSAQLVEVLGQVPSLRPAVVGLAGSESPAALGAAVEFVLEGLHLSKRLNKDAAGARATYRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI5</accession>
    <name>A0A7K0JNI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03560 family F420-dependent LLM class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="30399" checksum="E119085D5AFE6551" modified="2021-04-07" version="1">MRISVKLQPQHASWEQLRQMWMAAEATPEVDAAWLFDHFYPINGADPAGPCFEGWTAAACLAAQTERLRFGLLVSGVTYRHPAVLANMCATLDVASGGRLEIGLGAAWNADEHAAYGIPFPTVGRRMDMLEEACEVIHLLLTESRADFAGSCYRLTDARCEPKPLQSPRPPFVLGGQGERRTLRIAARWADQWNFPGREPDVLAAKLEVLRQHCADVGRDPAAIEVSVHLFDPTVAPDAAAQARRLVAAGADHLVLYFQTCFEPGVLRDVSAAVADAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ1</accession>
    <name>A0A7K0JNJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fpg/Nei family DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000011">
        <property type="protein sequence ID" value="MST31159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08971">
        <property type="entry name" value="AcNei2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044090">
        <property type="entry name" value="Nei2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="13193" checksum="545B27AAA56506CA" modified="2021-04-07" version="1" fragment="single">MPEGDTIFRTAASLRRWIGGREVTAARCVRLGVDLAPLVGQRVEAVDARAKHLLIHFSGGRTLHTHMRMTGSWHVYPTGERWRKPAHQARVVLECGARTAVCFNAPVIELLDERALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM9</accession>
    <name>A0A7K0JNM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type II secretion system F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_00390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="71"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="274"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="407" mass="43945" checksum="AB9A224ED2DF5F2B" modified="2021-04-07" version="1">MPTTFAYKVRDTSGKLVTGQLEADNTALVVSKLREMGLTPISVDKANSGFKREITIPGLGNRVKLKEVAVFSRQFATMIDSGLTLTRSLAILVGQTTNKHFAGVIDRVRADVESGLSLSQALDRHPKQFPRLYVSMVRAGETGGSLDQTLLQLATTLEKQVELRGKVRSAMTYPVSVMALVLVILAIMLVVIVPIFKKMYESLGSHLPVPTQVLVSISNLAVVLVPVLLGVGIVGLFVFRRWVATDRGRLAWDSFKLRLPIAGALARKTAITRFAGTLSTLMRNGVPLLEALDITRGTVNNAVVARAIEAAAEGAQRGEPLTQALAQHPVFPYMVVQMIGVGEETGAVDDMLAKVAQFYEQEVEATINSLTSILEPLMVVVLGSVVGSIVICLYLPMFDIYKAVGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR5</accession>
    <name>A0A7K0JNR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000084">
        <property type="protein sequence ID" value="MST31501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="24505" checksum="080DD0F2461460F7" modified="2021-04-07" version="1">MTDHGGAPGPPPPAAARSLLRFDGVERAVHWANAALFAVLVLTGAALYVAPLTALVGRRVLVERVHVVAGLVLPVPVVLALAGSWGRGLRRDLARLNHWSADDRRWLRTVGAPAVRRQVALRVGKFNAGQKLNAAFTAGGGLVMLGTGCLLRWYRPFPLAWRSGATLVHNWLAAAFVVVITGHVLLALSDTVALRSMLSGRVGRDWAGRHAPEWLAELDGEPIRRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS1</accession>
    <name>A0A7K0JNS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11643" checksum="1BCB03AD8B3BE970" modified="2021-04-07" version="1" fragment="single">MSRSQLQQITELLRTSPLDLGGDVTVMRQVFDEMLAATPVPPEVRTTPVTLGGVPAIEVVAGPDTGPGAILYFHGGGYALGSAARSVNLGADIARRTHRPVYTVDYRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT1</accession>
    <name>A0A7K0JNT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="18143" checksum="2E01FA5A100B54CD" modified="2021-04-07" version="1">MGDSAVSVVVGNPKPGSRTLAVARAVAEVAAHATGQSGPPWVLDLADHRDDLLDFSSARIPPLVEALGRCRIAIVASPTYKATYSGLLKAFFDWVPQTGMSGVAAVPVMVAATANHALAVEVHLRPLLVEVGAMVPTRGIFFTEGQLADPLPVIERWLGTASTPLRALSARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP53</accession>
    <name>A0A7K0JP53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_03290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="7">
        <location>
            <begin position="121"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Ada_Zn_binding" evidence="8">
        <location>
            <begin position="214"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="29134" checksum="0073BB9402E0CE52" modified="2021-04-07" version="1">MNRAVPSPSDSTTRALRALRSEPPPGFAGRVLARVGLVEPDRFVRVDSPAGPLFVAFNSVGVCHVLVAAVVDDDPQRFVARHEARFGRPATPADHPPAGLVTAARTSRGRQLRYDLRGLTDFEQAVLGAALDIPPGEVRPYQWVAEQIGRHKAVRAVGTALGRNPIPVLIPCHRVIRSDGQPGDYGYGPQLKQHLLTHEGVDLARTERLARAGIRYIGSDTTHVYCLPTCHAALRITAPHLVPFRSPEQAGVAGYRPCEQCRPTPAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP69</accession>
    <name>A0A7K0JP69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000114">
        <property type="protein sequence ID" value="MST31681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="239" mass="25070" checksum="32A9ADE5FE25B713" modified="2021-04-07" version="1">MNPDGVAAALAAQAEGFYSAEAAVGLLIEHRSWLARADFRAFVDVTPSLVDDRVMMASVDWEAALTANLPASSSETQMLAVAAELAGVDTGRSLQDLICGLDRANTTLVVRAVLHSQRGADAAAVTVTPFRPADGNLDRNAEPRVEVPPAGGRRDAARRAGAMTAQPPVPCDSSRTGGRRRPGVLGDECRYYDEPGRFDGSDDAVQRLHPGRAEHDGRTAQPGGRCVVDGGDDLGPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC8</accession>
    <name>A0A7K0JPC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000134">
        <property type="protein sequence ID" value="MST31783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="12033" checksum="B4AEE04F574F4430" modified="2021-04-07" version="1">MPPVVKINAISVPPERAEEMAARFAARAGEVESMDGFEEFQLLRPTDDRDTWLVYTRWRDEAAFEAWVSSSAFTRGHAQPQGPGGPVARHSELWSFELAQDARSTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG5</accession>
    <name>A0A7K0JPG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="955" mass="108273" checksum="32DE6E0F4EAA57EB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH5</accession>
    <name>A0A7K0JPH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000155">
        <property type="protein sequence ID" value="MST31858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="274" mass="28900" checksum="A2C0B4ECBC014575" modified="2021-04-07" version="1">MAVHAHPDDEATSTGGVLARYAAEGVRTVLVTCTDGSCGDGPGGVKPGEPGHDREAVAAARLVELRRSAELLGVGALELLGYRDSGMMGWATNDEPGAFWGMDVAEAAAPLVELMERHRPQVVVTYDANGFYGHPDHIMAHRIATAAAATSGVPAKLYHTAVPRSGLAEFAAALREAGVEPPGPSDREEGQFAEAEEPAWGTPDELITTAVDVSGYVEAKFAALAAHASQADNVFFLRLGPDLYGRFFGREWFVRASDRSGAAVPEDDLFAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI7</accession>
    <name>A0A7K0JPI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybutyrate CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000155">
        <property type="protein sequence ID" value="MST31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="1">
        <location>
            <begin position="255"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="413" mass="43968" checksum="9982E19DC2995DCD" modified="2021-04-07" version="1">MRVVGERQLEAALAAVGGGEPRVVVGGNFATPRALLGIWDRAVPRYRLFMINAQGPLPGRDEVIFETPFVGPGMRDGGRRLDYLPMRLSLVPQLFARSRPPDVVLVQTSPPRAGKVSLGTEVNILVAAVEQTRARGGTIVAQLNPAMPYTFGDGELDVGLFDLAVEVGEDLPSPAPPGPLDEVTASIGAHLGGMVADGATLQIGIGTIPDAALGTLGDRRGLAVWSEMVSDGVLALERRGCTERERPIVTSFVFGSPELYAWADRNPRLRLARTETTNDPARIARQRLMTSINTALQVDLCAQANASEVRGRIYSGFGGQTDFIVGALHAPGGHAVIALRSWHAKSDSSNVVPLLPVPVTSFQHSAIVSEHGRAEIFGRSQRAQARLITERVAHPDARAELAEAAGRLGLHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN2</accession>
    <name>A0A7K0JPN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000164">
        <property type="protein sequence ID" value="MST31883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="21679" checksum="111CB45ACDEFBB03" modified="2021-04-07" version="1">MPDGWCGARWSWKAAGRASRRRAPTSPVVAVGVIVGLLAAVTALRWELDRAGEAVALLYVVPIALAGVRFGRRGGLTVAGFGVAAFAGLELVRARGDVDLTGWVAPLLAMALMGGLVGHLSEASARSEAALQVQARHLEELRHTRSAAIRAGDSMVQQLAAARWMLEAGNGEGALAALESTVAVGISEFSSSLPPLSPNRSAPGGLLDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP1</accession>
    <name>A0A7K0JPP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000172">
        <property type="protein sequence ID" value="MST31905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="142"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="364" mass="38874" checksum="35CF74BA30D27EED" modified="2021-04-07" version="1">MGELEAEVDPGSLGDDGPGPGGGSGGGDEGGEAAERDVGHGILLRCGVGVIVSIRPQGLVGHRLGRGSRTAPPAVVAYSRRCRRPAEARCHDDGGMDATPQFRVDLYRGTAHDYDRYRVPYPSALIADLARRAALSGTGRLLDLACGPGRVTFALAEHFADVVAIDQEEEAIRYAAAVAGERGASHITWRSGRAEDADLEGPFELVTVGDAFHRLDRPRVAARAAQWLQTAGHIALLSTSMPWQGSAPWQEAAMELVVHWMELTGSLRNIPANLADTVAESPHLAVLAGAGLEVVGTYEFTAPHRWTLDGLIGFAHSTSILSRAALGDHAEAFERDLRDRLLAVRPDGDFEDSVHFAYDLAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ8</accession>
    <name>A0A7K0JPQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="25483" checksum="E32F9C6D1371B49F" modified="2021-04-07" version="1">MGEGGGPQEQPPCRRPSRPAALGRLDLVGADEDRLQAVPRAQGAAPVEGLPAPGDPSLAEKVQQAAGKVIGTGRPLGGEEGEGVAGEQHGEPVGRPEPRPQAPDHLDVVAGGAGGGQHALAQAEQAHGTQQVVQGGERGEVLLDRGGAAEQIPAGVVVLDLAQHRVRQATARSQLHAVDGQVEQEADRGRHRTGGPLDEQIGAGQVEAVAPGTRPTPQVVVMGVPGVGHTAAGRTPGAWYYRVTPRPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ9</accession>
    <name>A0A7K0JPZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_02755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="192"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="410" mass="43005" checksum="50C91E2939CFF554" modified="2021-04-07" version="1">MALEPAGPGADSSVEPSISRPAVERAKQHVARTLACDAEQLVRLSERLHANPETAWEEHRAAGWVAELLDEAGFVVTPAYLGLDTAFLATYGTGPFRLGLCAEYDALPGLGHACGHNLIAAITVGAARSLAALADDAGLTVEVYGTPAEEGGGGKIELLERGAFAGLDLAMLAHPAPVDIAEAEALAVSHSHVAFTGRAAHAAAFPEQGINAADAFTVAQVAIGLLRQHLPQTVRVHGVVTDGGVAPNAVPDRTEGRWYVRAERLEALAEVERRVWHCFEAGALATGCTVEVTPESKPYAEFRTFEPAQRAYVANAARLGRRFDQDSPGRRMNRASTDMGNVSQAVPAIHPYIGIDSLPALNHQPEFAAHCVGPAAERALLDAATALAWTALDVATGETIAPAATPDSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ25</accession>
    <name>A0A7K0JQ25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000192">
        <property type="protein sequence ID" value="MST31997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="9696" checksum="5BD82C6E9C98E17E" modified="2021-04-07" version="1">MAMSLEEMELETVEFVPAREVMCTVWYQPPTHCDGGQGQGGYGNGGWSGGGGHETTTTFTQNSQGTYCANGGQGFSILSGNNVLDGNNVSIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ66</accession>
    <name>A0A7K0JQ66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000210">
        <property type="protein sequence ID" value="MST32090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="16091" checksum="A261C251F9F86A22" modified="2021-04-07" version="1">MSSPGHPDASGGDIEPVPASPLPSPPGPAGSWDLDLAAASLRMDTGDTDALFEALGDKLERILGSRAQVTREGGLRRRTKRVVKIVVDAGAARLEAARGRAGASFSEAHAVRGITLRTTELAAEEWLDRLVAIVEAEAARSNDVRTALGRMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM2</accession>
    <name>A0A7K0JQM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">menA</name>
        <name evidence="7" type="ORF">GHK86_05800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000251">
        <property type="protein sequence ID" value="MST32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="28754" checksum="F05B258F77881853" modified="2021-04-07" version="1">MSNRWVLGARLRTLPASVVPVAVGTGVAAAGGHVVGWRAGLAAVVALALQVGTNYANDYSDGVRGTDEVRVGPTRLVASGLASPGAVKRAALLAFAVAGVAGLVLAATVSWWLLAVGAASVAAGWLYTGGPRPYGYDGLGELFVFVFFGLVATVGTAYVQLERITALAWVAAVVPGLLAVALLVVNNLRDIHGDAAAGKRTLAVRVGAPATRIGYALCLGLPFVAAVGIATAFRPWALLALLALPLAVGPMRAVLAGAKGGDLIAVLGATGRVQLVVGALLTIGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX8</accession>
    <name>A0A7K0JQX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000269">
        <property type="protein sequence ID" value="MST32317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="231" mass="24701" checksum="D151581C2FF139F2" modified="2021-04-07" version="1">MTLATRSPAPGGSQRRRSDAEVEGNARLTASTGLVLLVLFAVQVGTVVASVKSHLTPHVVVGLLLVPPLLVKLGAVSWRFVRYYQRDPAYQRKGPPAPALRIMGPALLLATLALFVSGITLLLAPTAFGGPRGAMFYVHDGSFYLWTLLLLGHLAGHRRDIRRLALRDWVGRSRATVRHAPLRQAIVLLSLAAGLALALALVGQVRGYQHVLHHARVASSFAASPKGGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR59</accession>
    <name>A0A7K0JR59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="3">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_05000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000209">
        <property type="protein sequence ID" value="MST32084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB_4TM" evidence="11">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10893" checksum="2B7E76E0C590F6F0" modified="2021-04-07" version="1">MTTGFVGDVTIFVLALLVGFEVISKVPATLHTPLMSGANSIHGVVLVGVIVLSAEVHGPLGYVLTFLAAAFAGANVVGGYAVTDRMLQMFKKRPAPKPAEAKAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR95</accession>
    <name>A0A7K0JR95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000296">
        <property type="protein sequence ID" value="MST32451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9091" checksum="9081066E9DD73515" modified="2021-04-07" version="1" fragment="single">MAMRDDCKYFQRRAYASGETAQFCALGLAPEAPWRCPDDCPRYARRPDLPGSGPGGGVEVRVEPDLHPDAVAVLSSAEEIIGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR99</accession>
    <name>A0A7K0JR99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000290">
        <property type="protein sequence ID" value="MST32433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="22673" checksum="BCBA0E30E0A72938" modified="2021-04-07" version="1">MPGAGVLLDLDGTLVDSNYLHTLAWKRALADCGEWAPSNAIHRLVGMGGDQLVPTLLGREVPAAAERRAEHYARLLPEVVAFPGAGELLSRLRAWGLAVVLASSAPGSELDPAVGLLGGRERFDAVTGADDVTRSKPDPEVFRVATQQAGLDPGRVVTVGDSVWDVEASRAAGYACIGVETGGFSRHELAEAGAVAVYRDVAELVAQARTSPVAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE7</accession>
    <name>A0A7K0JRE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="12122" checksum="532E7BF0B9195CB1" modified="2021-04-07" version="1">MVVDRAELEPAAALFRSLGDPARLVILQRLAAGAARVVDLTAGLGLAQSTVSKHLACLQGCGLVSLRPVGRASMFALARPELAGLLGAAETIPAATGNAVALCPTYGTAAQRGTPPGTGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI0</accession>
    <name>A0A7K0JRI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein GHK86_07445</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000329">
        <property type="protein sequence ID" value="MST32556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="27498" checksum="44532C2883C688CD" modified="2021-04-07" version="1">MSGHSKWATIKHKKGAADKARGKLFAKLIRQVEVAAREGGGDPDSNPTLRTMFQKAREASVPLDTIDRAIKRGTGELEGVRYEQISYEGYAPCGVAVIVEVLTDNRNRTGAEVRSAFSKNGGSMAEPGAVSWQFERKGVILVPKAPSGRGPVTEDELMLVVLDAGAEDIAEAGEESWQVTTPPTELNAVRAALDEAGIPAESTELSMVPTTVVALDSEADAKKVLRLIDVLEDHDDVQNVYANFDIPDSVLELVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ9</accession>
    <name>A0A7K0JRJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_07475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000330">
        <property type="protein sequence ID" value="MST32561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="233"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="295"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="521" mass="55118" checksum="5FA2635140B87F92" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR8</accession>
    <name>A0A7K0JRR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetolactate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000346">
        <property type="protein sequence ID" value="MST32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="57"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="18773" checksum="716975F1BB946CF3" modified="2021-04-07" version="1">GARPARPSGPIEPASLAAAVGATLPDDAIVVDESISASFGLGSGLAGAAPHDLLTLTGGSIGFGLPCATGAAVAGGGRPVVCLEGDGSAVYTLPALWTQAREGLDVTTVIVDNGAYAILAMELDRLEAGTPGPGGRSLLDLSGPSLDFVSLARGFGVPATRATTAEELAAQLEAAHAEPGPHLVDAVMTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU1</accession>
    <name>A0A7K0JRU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">galT</name>
        <name evidence="15" type="ORF">GHK86_08030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="12"/>
    <dbReference type="EMBL" id="WJHE01000355">
        <property type="protein sequence ID" value="MST32668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="13">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="14">
        <location>
            <begin position="72"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="11">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST32668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="24385" checksum="94DB404265835A7A" modified="2021-04-07" version="1">GRVRMLVDVWADRTEILGAEPAVAYVMPFENKGEIVGTTLSHPHGQIYGYPEVPPRARRELDAARAHRARTGRCVHCDVVAAELADGRRLVACVDGWAAWVPFWARFPYEVHIAPSAHHPALPDLPHREREGLAAMLTRVAGAYDRLWGFSLPYVMAFHQQPTDGNPDWPALSHLHVEFAPPHRAADRLKHLAGSELAGGAFVTDVAPETAAAELRAALPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS24</accession>
    <name>A0A7K0JS24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="32518" checksum="E6222C91D7686C66" modified="2021-04-07" version="1">ATAGAIALTGDPRRWASEPGMPGVVHYWGPYLYRSAFHATTEAEECERALAHLRDLVTVEGPQTVAAILLETVVGTNGVLVPPDGYLAGVRRLCDEFGIVMIADEVMAGFGRCGEWLAIDHWGVTPDLITFAKGVNSGYVPLGGVILSDAIAATFARRPYPGGLTYSGHPLACASAVASIGIFEEEGIVEHARALGDDVIGPGLAALADAHPSVGEVRGLGVFWAVELVRDRQTREPLVPYNASGPDAAPMNEFAAACKQRGLWPFTHFNRTHVVPPCTTTPEEIREGLAILDEALAVADRYYTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS25</accession>
    <name>A0A7K0JS25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliD</name>
        <name evidence="8" type="ORF">GHK86_08395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000375">
        <property type="protein sequence ID" value="MST32740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="411"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="582" mass="56034" checksum="851E9DDC1A7C1A8C" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS79</accession>
    <name>A0A7K0JS79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytoene/squalene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000390">
        <property type="protein sequence ID" value="MST32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="33000" checksum="9B37663CA50EDF2B" modified="2021-04-07" version="1">MAAVDLEASYRRCRRLNRRFGTTYYAATWLLPPSKRRHVHALYGFCRYADDIVDDLGPVPLAAREEALGDFGDRFFADLAAGGSDDPILAAVVHTVRALGIDPDCFRRFLRSMAMDLRVATYDRFEDLLDYMDGSAAVIGEMMLPVLEPASEEALGPARDLGIAFQLTNFWRDVGDDLLRGRVYVPQEDLDRFGARAALAERRVTPEWVALMRFEVERARAFYRSADRGIALLPPVSARCIAGARILYAGILERIEEAGYDVFHGRARVPGWRKAGVAARLLRPTPPAVLLPDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA9</accession>
    <name>A0A7K0JSA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000403">
        <property type="protein sequence ID" value="MST32836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="23056" checksum="221EEE6AD0FFE33D" modified="2021-04-07" version="1" fragment="single">MLVAFDEFQDVLAAGNADAVIRSEIQHHGEAASYVFAGSHVGMMRELFGDRRRAFYSQARPIELPPLPAEELADWIGHRFTASAKDVGTAIGPLLETAAGHPQRAMLLANALWAVTPRGGAAGEEEWAAAMERADSETRDEIKTVRGALSTTERRVLTTTAEGGRGLYARGGPGPRGGSVTAAVRRLEDLGELVAAPGTPSGYRVVDPLLARWVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD4</accession>
    <name>A0A7K0JSD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sulfate exporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_08985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000411">
        <property type="protein sequence ID" value="MST32852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="23313" checksum="51C6C7E568D17617" modified="2021-04-07" version="1" fragment="single">ALAVLPGTAAAAAIAAVATGLAHFAPVVGAPVIAILLGIAAALVRRPSARMRPGMAFTSKRVLQGSIVLLGLGLSLGQVVSAGRHSLPVLVGTLVIALLAGWLAGKALRLPGDVATLVTVGTAICGASAIAATDAVIDADGADVSYAVTTIFTFNVAAVLLYPTIGHALGFSQHTFGLWAGTAINDVSSVVAAATTYGPVAASYGVVVKLTRTLAIIPISLGLGLLRSYRSSGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG5</accession>
    <name>A0A7K0JSG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribulose bisphosphate carboxylase large chain</fullName>
            <shortName evidence="9">RuBisCO large subunit</shortName>
            <ecNumber evidence="9">4.1.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbbL</name>
        <name evidence="12" type="ORF">GHK86_09135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:23124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="4.1.1.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterohexadecamer of 8 large chains and 8 small chains.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RuBisCO large chain family. Type I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.39" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000418">
        <property type="protein sequence ID" value="MST32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08212">
        <property type="entry name" value="RuBisCO_large_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01338">
        <property type="entry name" value="RuBisCO_L_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020878">
        <property type="entry name" value="RuBisCo_large_chain_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020888">
        <property type="entry name" value="RuBisCO_lsuI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00157">
        <property type="entry name" value="RUBISCO_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="8 9" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="7 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="11">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="10">
        <location>
            <begin position="147"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" description="in homodimeric partner" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="476" mass="52636" checksum="95836E75C99C9FC9" modified="2021-04-07" version="1">MSDRWSAGVIPYAQMGYWEPDYEPKPTDVLAAFRVTPQPGVPPEEAGAAVAGESSTATWTVVWTDRLTANTHYQAKCYRVDPVPGNPEQYIARIAYDLDLFEEGSIANLTSSIIGNVFGFKALRALRLEDLRIPAHYTKTFQGPAHGIVMEREYLDKYGRPLLGATVKPKLGLSARNYGRVVYEALRGGLDFTKDDENINSQPFMRWRDRWLYCMEAVNKAQAETGEVKGHYLNCTAGTMEQMYERAELAKELGSVIVMIDLTVGYTAIQSMATWARRNGVILHLHRAGHSTYTRQKNHGVSFRVIAKWMRLAGVDHIHAGTVVGKLEGDPHSVAGFYDTLRLDHVEPDPAKGLYFEQDWVSMPGVMPVASGGIHAGQMHQLLHHLGEDCILQFGGGTIGHPMGIAAGATANRVALEAMIKARNEGRDYLVEGPDILKAAARRSRELDMALSTWGDVTFTYESTDVPDVVETPTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK1</accession>
    <name>A0A7K0JSK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000435">
        <property type="protein sequence ID" value="MST32926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029449631" evidence="2">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="7992" checksum="AC57C78123BAFF72" modified="2021-04-07" version="1">MVKASVVALLLAVAMGVVVSHGLGPAVAWMTQGLQGGPRSLPAQTVRLVSAACAALVFLWWFSSSRRTVVRRGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM2</accession>
    <name>A0A7K0JSM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">rRNA maturation RNase YbeY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ybeY</name>
        <name evidence="9" type="ORF">GHK86_09455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000439">
        <property type="protein sequence ID" value="MST32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20184" checksum="F1079218BE0BFAD1" modified="2021-04-07" version="1" fragment="single">MTVEVFAADEQHDQPVDTLRLVRLAEAVLADEGVRGDAELSVLFVDEGSIAELNKKFLGKDGPTDVLAFPIDEEPTESGRSPDSGGSGPGFTGEVEEAPALLGDVVICPAVAHRNAPEHAGSYEDEMALLVVHGVLHLLGMDHLDDDEAEEMEERERELLARHHGVMTNPRFRPRPAGAPGGPGPAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP1</accession>
    <name>A0A7K0JSP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000441">
        <property type="protein sequence ID" value="MST32955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13820" checksum="72CC5C838AA51C32" modified="2021-04-07" version="1" fragment="single">MRTEYEFVLPRGFVDLSGTVHKRGVMRLATARDELEPLRNPTISGPDDPRLTLLVLERVVTQLGSLPLVTMAEMEGLFAADLAYLQDFYGVINFGTEEDIEQLLAARAHQQQPGAEVAQLVIPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP3</accession>
    <name>A0A7K0JSP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000440">
        <property type="protein sequence ID" value="MST32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="111" mass="12456" checksum="0D04B1B629CA9D38" modified="2021-04-07" version="1">MPFFALFLFLSFGVMALTMLGERGYRRAREARPILATGWGVALAWLADVNMWSGWGIPNLRYDWVGTTLTGLALGGTALLVYALFGFFFGMSRKLDDQAEQIERTELRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR6</accession>
    <name>A0A7K0JSR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ORF">GHK86_09730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000449">
        <property type="protein sequence ID" value="MST32996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="459"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="584" mass="62144" checksum="BE714DE347EBE7C7" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT07</accession>
    <name>A0A7K0JT07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000367">
        <property type="protein sequence ID" value="MST32714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="118"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="548" mass="59220" checksum="6D9D2340FAFD27AF" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT41</accession>
    <name>A0A7K0JT41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000381">
        <property type="protein sequence ID" value="MST32754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="508" mass="51253" checksum="484D048A4DB661ED" modified="2021-04-07" version="1">MPSTIPSNCSADATSALNTLFASLPAGAVVNFPDNGCYLVSGSATSDLLIANTTGVTLNGDGTTFRQLTYKTPSGADACGVLIRDPILTLQANRDLTVNNLVLDGPHGSGTQYDCGGAMNEGDAGLLIGGPADAVGNHGVTFDAVTVENTDGDGIDLYPQLATNSGANSNIVFEDGALQNWGWFGIVGEGVQGFSFSHNNVIGGGFMDVEVDNACPANCLNPDGTLRGDGVAAMTISNNTFQVGSFLVSEGGRGCMPQTNWVISDNNFGSGNAGVSLDGSYGEPACPLDNTGFTYTYNSGGTTGSACGSSYGTPPGFCAGLNLAGWAKVTIANNDIGFPIGVLGTRRTITGASISTTGGVSSLTSSTATFAASDVGDLVVAQGVTLGDTIASVTSPTTATLREPAAADGSNLTVAIGEGSYYPDAPLIQAVGLCGVYGATIANNVFDGAYSAWAPTRCFDETGYPTPTTGVTACGNTWGVIHPQPYYAFTSLTPKPAPKPAPLADAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT63</accession>
    <name>A0A7K0JT63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rpsD</name>
        <name evidence="9" type="ORF">GHK86_10365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000491">
        <property type="protein sequence ID" value="MST33120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="8">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="24257" checksum="25DF5E56ED3A851B" modified="2021-04-07" version="1">MARYTGPVCRLCRREKMKLFLKGPKCDSMKCPIERRPYPPGEHGRDRMRQGSEYLTQLREKQKARRIYGVFEKQFRNLYEEANRQTGITGENLLRMLELRLDNVAFRAGWGASRAQARQLVRHGHVMVNGKRVTIPSYRLRKGEVVSLRPKARQMIVVRHNLDTLDRQVPAWLEGGADGHEVTVRELPLRDHIDVPVRESLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD6</accession>
    <name>A0A7K0JTD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF86 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000412">
        <property type="protein sequence ID" value="MST32854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="70" mass="8043" checksum="1444AE87B7B367A4" modified="2021-04-07" version="1">VRAAMPAVPWREWRAQRNLVAHVQHRIDPQLLWVTLDRDLPSLGRALGRWQQRSLQQESTRTPAPAALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG7</accession>
    <name>A0A7K0JTG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2182 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000527">
        <property type="protein sequence ID" value="MST33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018688">
        <property type="entry name" value="DUF2182_TM_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09948">
        <property type="entry name" value="DUF2182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="224" mass="22904" checksum="628638B7CDBF82D9" modified="2021-04-07" version="1">MVYEATVMGNGPGTMGLGPAPFVAIWALMMAAMMLPSVAPTASFYARALGPHAGGRLAGFSAGYLAVWALTGIPAYAVMALSGRVVAHDPVAARVGATALLAAAGTWQLTGAKDVCLVRCRSPLGLLVRYGSYRGRWRDVRAAVHHAGSCLGCCWALMALFVVFGVMNVAAMGAIAAVVLLEKLAPRGRGIARLVGLACLGLAVVVMAVPGLAPGLHASPMHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG8</accession>
    <name>A0A7K0JTG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="11098" checksum="69D34A09B31544B8" modified="2021-04-07" version="1">MQRSQESLADVLERVLDKGIVVAGDIAVNLLDIELLTLKVRLLVASVDTAREMGIDWWENDPFLSRRAGDLEKENKELRERLERLEALLPAASEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI5</accession>
    <name>A0A7K0JTI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stp1/IreP family PP2C-type Ser/Thr phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000405">
        <property type="protein sequence ID" value="MST32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="25736" checksum="D3CCC442A84D029C" modified="2021-04-07" version="1" fragment="single">MTRLVAGSATDVGLVRAVNQDHMLVAEPLFAVADGMGGHAAGEVASETALDALLGAIGAAPPEGGWTAAELGDAVRAANRAVWEEAQANPDFRGMGTTLTALALIRDGGADRLAVANVGDSRTYRLRGEQFQQLTVDHSLVAELVAEGQIRPDEAETHPQRHVLTRALGVYPEVEVDVLLTDLQLGDRFVLCSDGLSREVSDAQIASVLRRLADATDAARELVAMAKLHGGSDNVTVVVVDVGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL7</accession>
    <name>A0A7K0JTL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_11240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000548">
        <property type="protein sequence ID" value="MST33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="513" mass="53420" checksum="4152801152A738C9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ5</accession>
    <name>A0A7K0JTZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DsbA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000585">
        <property type="protein sequence ID" value="MST33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="220" mass="24180" checksum="CFA90D9E19DEFDFC" modified="2021-04-07" version="1">MQVDIWSDVVCPWCYIGKRRFERALVEFEHADEITVGWHNFELDPAAPKASNLPMAEQLSRKYGRSLEESQAMLADMDRLAASEGLDYHLAETTGGNTFDAHRLIQLAGSHGLAGVMEEALFAAYFVQRVPIGDHDILRRVAGEVGLPADEVDEVLAGDRFADEVRADEALATEIGATGVPFFVVDRKWGIPGAQDTDTILSVLRRAWERRGGEPAAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ3</accession>
    <name>A0A7K0JUJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1810 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014937">
        <property type="entry name" value="DUF1810"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036287">
        <property type="entry name" value="Rv1873-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08837">
        <property type="entry name" value="DUF1810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008546">
        <property type="entry name" value="UCP008546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140736">
        <property type="entry name" value="SSF140736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="18098" checksum="0E71C771AC6AFECD" modified="2021-04-07" version="1">MNERRAVGPGAFDLLRFRTAQEQGGTFDGALGELRAGRKQTHWIWFVFPQLAGLGRSPTSRRFAIASLDEARAYLDDPVLGPRLREAASALLAHADRPAAAILGELDAAKLRSSMTLFRRAAPGEAVFARVLDAFFHGQPDPATDRLLADADADADADADADGDGPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN4</accession>
    <name>A0A7K0JUN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000681">
        <property type="protein sequence ID" value="MST33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="9263" checksum="F8269F4E29770313" modified="2021-04-07" version="1" fragment="single">MLAEVRAAGYTGSARSLRRAVAVSKKRWRAQRRVYRPWVPVPGEHLVFDWTTEGGWQVFCAVMAWSRWRFVRVARDQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY1</accession>
    <name>A0A7K0JUY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bac_transf domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000707">
        <property type="protein sequence ID" value="MST33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="16779" checksum="FE85F8D01D201E04" modified="2021-04-07" version="1">VVKLRTLPPQAEPDTTWTGAPAPGGLPGFLRDRHLDELPQLWNVLRGDLSLVGPRPERPFFAARFAEEIEGYAGRTRAPAGLTGWAQVHGLHGDTSLVERARFDNAAIEWWTPLQDLVVLARTLAAAWRGATRPSSAPKQATGAHRPPRLGGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV44</accession>
    <name>A0A7K0JV44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000733">
        <property type="protein sequence ID" value="MST33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047669">
        <property type="term" value="F:amylosucrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11324">
        <property type="entry name" value="AmyAc_Amylosucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044077">
        <property type="entry name" value="Amylosucrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="109"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="659" mass="72881" checksum="F03B7F18FCB7D918" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV72</accession>
    <name>A0A7K0JV72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000753">
        <property type="protein sequence ID" value="MST33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="8795" checksum="BC30F0FFD015CA90" modified="2021-04-07" version="1" fragment="single">MTEQGGSGELMSCRWLRPPEGPGPSWTTSVISEWELRRATYTDRHPHEEVNVVLEGVLHVTTAGVTRTARAGEVVVVAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV79</accession>
    <name>A0A7K0JV79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ORF">GHK86_12130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000605">
        <property type="protein sequence ID" value="MST33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="28023" checksum="0A8EAA493D12012B" modified="2021-04-07" version="1">MDLDGLDPNRMPRHVACVMDGNGRWATKRGLPRTEGHRAGEEALFDAAQGALELGLPWFTVYAFSTENWRRPGDEVRFLLNVIADQLLTRRRDDLHALGVRIRFIGRRDWRVPRWVGRRMDEAAALTAANTAMTLTVAFNYGGRAEIVDAVRSIVAAGVPASKIDERTVARHLYDPTIPDPDLVIRTSGEFRISNFLIWELAYSELVFSDVLWPDFRREHLLEAIREFQARDRRFGNTGRHDGIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV92</accession>
    <name>A0A7K0JV92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amt</name>
        <name evidence="10" type="ORF">GHK86_11905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000586">
        <property type="protein sequence ID" value="MST33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="459" mass="47680" checksum="A10331841CB8DAFB" modified="2021-04-07" version="1">MEAVALSAQAFNPDKTGGINPGDNAWILVSTALVMFMTPGLAFFYAGMVRRKNVLGMIMQNWVCIGIVSVVWVLVSYSLAFGVDAGGLGLIGTLHFAGLGHIDSQPVPGEALTISPVVFVLFQAMFAVITPALITGAIADRVKFGAFCVYVALWSVVVYAPIAHWVFSPTGWLYKLGAEDFAGGTVVHINAAMGGLGVLLVVGNRKGWPSKPMKPHNVPFTVLGAGILWFGWFGFNAGSALAANNLSAHAFLNTNTATAAAMLTWLLTERIRFGKATTIGGASGAVAGLVAITPSCGYVNLLGALVIGAVAGVLCCLACNVKFRLKRDDALDVLGVHFVGGVVGAVLIGFFGVDTFNSAAAKGLFYGGGPALLGKQALGVVAVAAYSLAASYLLALLIDKTMGLRVTEEQEEAGMDISLHDESAYDFETVLSSITHGLTGGEPVNPFATQATGTREVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE6</accession>
    <name>A0A7K0JVE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000752">
        <property type="protein sequence ID" value="MST33862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="381" mass="38991" checksum="AD8AE4F1CEA49BF2" modified="2021-04-07" version="1">MAGLGITATGKVWGRTAAQLAADAVRLAADDAGLSMGELDGLLVSSGVTGGVHLGLARDLGLRDLALLTEMQAFGSTAAAMVQVASLAVQSGMAKAVACVFADAPLRPGGRSGSAYRRAPRVPAGWDGLLAASGVLGVNPLYALAARRHMERFGTTSEQLGHVAVAQRAWAAGNPRAQYRDPITLADHQASRFVADPFHLLDCCLVSNGGAAVIVTSAERAADLAQPPVTVLGWGQCHPGRFLRRHDDFGLVTGAARSGPAALAMAGVRLDEVDVAELYDCYTFTVVVTLEDYGFCPKGEGGPFVASGVLGPGGGLALNTGGGQLSSYYLWGMTPLSEAVIQARGAGGARQAPHHDTVLVSGNGGVLDHHATLVLGGPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH3</accession>
    <name>A0A7K0JVH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000793">
        <property type="protein sequence ID" value="MST33967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6283" checksum="FA49DF54A39CB28C" modified="2021-04-07" version="1">MGAATYTTEQLAELCGLSAWALYSSVRRGDPPVQPIRVGRRIVWPKAAVDALLGIGGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI0</accession>
    <name>A0A7K0JVI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(Fe-S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000624">
        <property type="protein sequence ID" value="MST33519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25179" checksum="01CE4ACE3E3EDC91" modified="2021-04-07" version="1">MRIALMVTCLVDGLFPDVGRATVAVLRRLGHVVEVPDGQTCCGQMHINTGYGPAAVGVVRHHVEAFAATDVVVAPSASCVGSVRHQHAALARQAGDTALAAAAEALAARTYELSELLVDVLGVTDVGAYYPHRVTWHPTCHSLRVLGVGDRPRRLLEAVEGLQLVDLPDAESCCGFGGTFALKNAAVSAAMLDDKLRRIAATGAERCASGDASCLMQIGGGLARSGSPTRPVHLAEILAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL8</accession>
    <name>A0A7K0JVL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000797">
        <property type="protein sequence ID" value="MST33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="15586" checksum="4DBAEE4E82AE1EBA" modified="2021-04-07" version="1">KVSLDPEVVAELAGHPRIIGTKDSSGDLEHLTRTARLTAGTDDFSVLTGTDGGFLDALTAAGDGLIGASVNVAPGFAQGLYEAARAGDADEARAIQRRIAAVVAACDQLGFPAGWKAALHVLGVCGSDPAHPLPGPDPAGLPALRATLAELGLTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL9</accession>
    <name>A0A7K0JVL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enterochelin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000786">
        <property type="protein sequence ID" value="MST33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15431" checksum="946003365F7B077E" modified="2021-04-07" version="1" fragment="single">MVASPRGLVGSIDEVVVDSAALRGNPLGDPASRPLWVYLPPGYHDDADRRYPVVYVIQGYTGQLAMWANRSPFRPTYLEAVDTLFAAGGTPPCIVAFVDAWTAYGGSQYVDSPGTGRYHTYLCDDVVGFVDAHYRTLADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN3</accession>
    <name>A0A7K0JVN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_12770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000651">
        <property type="protein sequence ID" value="MST33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="24300" checksum="E9BB094A71259401" modified="2021-04-07" version="1">MSMARVLVVDDDRALLRAMRVGLAAKGHEVTVAARGQEGLTKVAVEAPEVVVLDLGLPDLDGLEVCRRIRGWSDVPIVVLSADGLEARKVAALDLGADDYVTKPFGMAELEARIRTALRHRAAVGAPPAELVVGDVELDVVHRQARRGGRDLELTAREFELLAYLARHAGKVCTHQMILGAVWGGEHGGEGESLRTHIYRLRRKLDDPDGLLLRTSPGIGYSLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT3</accession>
    <name>A0A7K0JVT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="13">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ribA</name>
        <name evidence="15" type="ORF">GHK86_15155</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="WJHE01000829">
        <property type="protein sequence ID" value="MST34053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST34053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="29115" checksum="1A959C4BC81C640F" modified="2021-04-07" version="1">AAVDLARLAGLPPAGVLCEVVSADRLSMARRPELEAFAAEYHLTLITIADLVRYRRRTERLVDRVSSARIPTDFGEFECFAYKSELDDITHIAIVRGQPAGRDNVLVRVHSECLTGDVFGSRRCDCGNQLHQAMRMIDEEGLGVIVYLRGHEGRGIGIARKLDAYRLQDRGYDTVDANLHLGLPVDSREYGIGAQILVDLGITTMRLMTNNPAKRGGLEGYGLQIVERVPIVTEPTAENIRYLQTKRDRLGHHFPEAGADHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT5</accession>
    <name>A0A7K0JVT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000832">
        <property type="protein sequence ID" value="MST34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13305" checksum="2DE9A4B73C867949" modified="2021-04-07" version="1" fragment="single">MLRKEDARFLRGQGHYVDDVSLPGMLHGAVLRSSYAHARINAIDTSAAEAHPRVKAVITGKTLESLGLAWMPTLSGDVQSVLATDKVRFQGQEVAFVIADDEYAARDALELIEVDYEPLPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT6</accession>
    <name>A0A7K0JVT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000832">
        <property type="protein sequence ID" value="MST34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17454" checksum="3F5D8CEB6D8621FC" modified="2021-04-07" version="1">MQIHVTVNGQETGHEVEPRLLLVHYLRNVVGLTGTHWGCDTSNCGACTVWLDGVPVKSCTTLAAQADGHAVRTVEDLDAGGDLDPLQQGFMEEHGLQCGFCTPGMLMTLRALLDRDPDPDEATIREAISGNLCRCTGYENIVRATRWAAAHAAAGAPEQEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW07</accession>
    <name>A0A7K0JW07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.99.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">betA</name>
        <name evidence="11" type="ORF">GHK86_15535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>A + choline = AH2 + betaine aldehyde</text>
            <dbReference type="Rhea" id="RHEA:17433"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15710"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.1" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000862">
        <property type="protein sequence ID" value="MST34128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008812">
        <property type="term" value="F:choline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011533">
        <property type="entry name" value="BetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01810">
        <property type="entry name" value="betA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="9">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="10">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="565" mass="61868" checksum="4F04811D2CCC8725" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW69</accession>
    <name>A0A7K0JW69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000732">
        <property type="protein sequence ID" value="MST33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="563" mass="58972" checksum="1C5D8DC1FE502DE9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF4</accession>
    <name>A0A7K0JWF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000898">
        <property type="protein sequence ID" value="MST34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="145"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="392" mass="41201" checksum="7AEDDAC68A4F5086" modified="2021-04-07" version="1">MSRRLGVGLLGVGWMGALHTRAYRRLTDHYPELDVRCELVAAADVGESGRRRAVEELGYARAEPDWRAVVDDPDVDVVSVTAPNALHREMALAVLAAGKALWVEKPVGRGLAETAAVAAALGPGAVTAVGFNYRTVPLVEHAGALVAAGALGRITGFRGWFLNDYASNPWGPLNWRFSRDGAGSGALGDLMSHVVDLATALLGPLREVVAVTDVAIARRPYAAGEGEHFATLGPGALEPPGDDVPTGEVENEDSARVLARFASGASGFLEVDRAAVGPHCSLGFEIHGSTGSLSWDFERMNELQLYLADTTGDAGYRRVLARPGHGDYGRFQPGPAISMSYDDLKVIEAARFVGAVLTGDPLAPGLAEALSAARAVDAMERSAASRAWEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI0</accession>
    <name>A0A7K0JWI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">truB</name>
        <name evidence="6" type="ORF">GHK86_16460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000938">
        <property type="protein sequence ID" value="MST34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5786" checksum="AEADCC19D4D6656C" modified="2021-04-07" version="1" fragment="single">MTSHDVVGRCRRAFGQKRVGHAGTLDPDATGVLLVGLGRATRLLRWMTGLPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM7</accession>
    <name>A0A7K0JWM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000962">
        <property type="protein sequence ID" value="MST34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="4">
        <location>
            <begin position="411"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="615" mass="67118" checksum="CF226C7A95BA2B22" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN0</accession>
    <name>A0A7K0JWN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000931">
        <property type="protein sequence ID" value="MST34292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09022">
        <property type="entry name" value="Aldose_epim_Ec_YihR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037480">
        <property type="entry name" value="YihR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="33095" checksum="DDE5E7CC78F142C9" modified="2021-04-07" version="1">MWIPAPSGRQVVLRHGEQHAVVVEAGGGLRTYGAGGVAVLDGYAEDEACEAGRGQPLLPWPNRLGDGRYDFDGTSFSLALTEPERHNAIHGLTRWSSWEVLEAATDRALLGHTLHPQPGWAWTFELRIDYRLGDTGLDVGLQVRNRSARRGPFGAGFHPYLAAPSGRVDDLEITVPASERSVTDERGLPVRVEPVAGTDLDFRAPTRLGDRQLDTAFGHLARDAQGMAVVDVTDPGTGRSVQVRMGPAWTHVMVFTGDTLGPRARQGLAVEPMTCPADALRSGTGLVVLEPDEIWDATWSVTPGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR1</accession>
    <name>A0A7K0JWR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000974">
        <property type="protein sequence ID" value="MST34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="22045" checksum="5E14CA2C9D3F3560" modified="2021-04-07" version="1">MQPVSAPGPTAILVRHGETEWSRARRHTGRTDLELTARGEEQAKAIRPLLEQAPPDVVLCSPLQRARRTAELAGLTPFELDDDLREWDYGEFEGRTTPDIAESLPGWTIWDGPWSGGETVEQVGERADRVLRRVLGEPAGSRVAVVAHAHLLRVLAARWVDEPARFGRLLGLDTATVSELGWEHGRRVVRRWNVAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV3</accession>
    <name>A0A7K0JWV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001000">
        <property type="protein sequence ID" value="MST34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="36"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="28353" checksum="21519C3C1343ABE7" modified="2021-04-07" version="1">VGSVLAARLGELDGAAAGRRAALTARSGVDPVELPPGRYEVVLEPRCVAYMLDFFTVYGFNAKAVQEGRSFARLGERQLDERLWVWDDATDPRQPGPAFDAEGTPKGRVYLVEEGHVTGVTHDRRTAAKAGGGAESTGHAVPGGAAMGAIARNLFLEGRDPVAVDDLVRGVERGLLVKDFWYTRVLDPKTLVVTGLTRNGVFLIEDGRVGPPVGNLRFTQSPVAAFGPGQVLGVGDDAVLAPGGLHVSWHHTPSLHLAGWNFTGNASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX7</accession>
    <name>A0A7K0JWX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001016">
        <property type="protein sequence ID" value="MST34455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="14"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="28875" checksum="5FFD7CF07E1293C6" modified="2021-04-07" version="1" fragment="single">MERDAHDYERHRYDVVVVGAGGSGLRAAIAAHEAGARTAVICKSLLGKAHTVMAEGGIAAAMGNLYPEDNWKVHFRDTMRGGKLLNHWRMAELHAREAPERVWELEQWGALFDRTSDGLISQRDFGGHRYARLAHVGDRTGLEMIRTLQQRTVALGVDVFMECTVTDLLKDGDRIAGAFGYWRETGRFVVFEAPAVVLATGGIGKSWKVTSNSWEYTGDGHALALRAGASLLNMEFVQFHPTGMVWPPSVRGILVTESVRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX26</accession>
    <name>A0A7K0JX26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4Fe-4S binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001041">
        <property type="protein sequence ID" value="MST34500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="519" mass="56346" checksum="7652D53AFB5BC44B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX43</accession>
    <name>A0A7K0JX43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001051">
        <property type="protein sequence ID" value="MST34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="13125" checksum="3EAFA27114DD0629" modified="2021-04-07" version="1" fragment="single">MPDRSTPQPPDVNQLVADAERALKDGAYVAVGLGVLAFQRAAVQRRQVVKRIERRRAAWQEHAGSGPLDRPMSRVVDQLGDATVALSSRLDEVGRSLAANADSTRAQLRELARSVDEAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB3</accession>
    <name>A0A7K0JXB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_17895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001083">
        <property type="protein sequence ID" value="MST34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="653"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="776" mass="81421" checksum="3E45919755B448A7" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC4</accession>
    <name>A0A7K0JXC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">GHK86_17965</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="WJHE01001091">
        <property type="protein sequence ID" value="MST34600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="127"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="246"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MST34600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="399" mass="43032" checksum="6493FA1910C61D36" modified="2021-04-07" version="1">MNRWTFTSESVTEGHPDKVADQISDAVLDAILTEDPAARVACETLLTTGLVVVAGEITTTAYVEIPTLVRDVVSGIGYTSSEMGFDGRTCGVAISIGSQSPDIAQGVDHAYEVRAGTAGEEDILDAQGAGDQGMMFGYACDETDDLMPTPIWLAHHLSYRLAQVRKDGTLPYLRPDGKTQVTFEYEDGRPVRLKTVLVSTQHTATVDIPTLLAPDIADHVIRPVVADRWGDGEYEVLVNPTGRFEMGGPHADAGLTGRKIIVDTYGGAARHGGGAFSGKDPSKVDRSGAYAARWVAKHVVASGAARRCEIQVAYAIGVARPVSIMVETFGTEQVAPETIEKAVREVFDLRPAAIIRDLDLRRPIYRRTAAYGHFGRDDAEFTWEQLSRLADFRAAVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ3</accession>
    <name>A0A7K0JXQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001178">
        <property type="protein sequence ID" value="MST34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="25183" checksum="609BAB2F8D8BA1C1" modified="2021-04-07" version="1">MATSQPYDAHEGAQPRDALETLELQDRLVVDLLDRWKAGTRHLSEQGDDVNTRWERGSEVKLLLQHLAVREEAKGRVRDALVDAGRDDLAARLEGDGPGRRADLDVLEEAARGLVAMNLNNPEVDRAVLRIDERVRPELLEESRLLRAVGEALGPVEDRGLPSDRNVRMHSVTHPSPEPRWFDKVGPLRAARAWYDHLRGSPHSGTSPKVDEAREYVPGPKHHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY21</accession>
    <name>A0A7K0JY21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001253">
        <property type="protein sequence ID" value="MST34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="20516" checksum="E45F0FF0435AFB02" modified="2021-04-07" version="1">MSRDPELGTFGRFVETPVEQMDAVTRAAYDLTRELLGLVPGPHRIWLANPTLAETIAPVGAYFQDRSTLTKAEIEIASCVVAGRWRASYATSEHERIGEDVGGLDPREVQALITGLPAAFDDVRQQVVYELASTLLAARVVPLGLFRRARDLLGDAGIVDMTVLLGWFTAVSLTLTAYDVPSDATGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY90</accession>
    <name>A0A7K0JY90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dala_Dala_lig_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001293">
        <property type="protein sequence ID" value="MST34907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dala_Dala_lig_N" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="25219" checksum="20D3B3D30A025BC5" modified="2021-04-07" version="1" fragment="single">GVAAPLAAWRAADEHAEGRRPVVVLFGGTTAERQVSVLSGTNVWLKLLHSDRFEPRPALLDRDGDAWLLSYPTALRHTVEEIVAACEEAAGAGEATGRVAGDVRRRLALEPWQLSAGDDRPRKVGLEELVAAHGFVFNALHGGAGEDGTLQRRLDALGVAYNGSGPEASALAMDKERTGRAVVAAGIAGVTSAPRRRVGLPADPAAAWADAVEACGTATLVVKPLADGCSAGVVPLAGEGEWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY92</accession>
    <name>A0A7K0JY92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_19585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001299">
        <property type="protein sequence ID" value="MST34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="29929" checksum="BA358BE0C42BCFB9" modified="2021-04-07" version="1">MVAVDAAVYGGEGMRKASPTVASRRRRASAVWRPVLLLAVGAYFVLPFVAALRYALQSDTGKFSFSAFAGITSQQGFGPAIGLSLRLLVLTVALTLGLMVPTAVYVHLRLPRLRRILDGITILPIVVPPIVLIIGVLDVAPTFAKASPYLLGFEYVVLAMPFAYRSLAAGLAAIDVKTLFEASRSLGGGPLQTLRRVLVPNLRAALLSATVLTVALVLGEFTMASLDQYQTFPVWIVAFDQNNSHVSTAVSFLALFATWALLMVISLLDRRGRTSPAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA4</accession>
    <name>A0A7K0JYA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001317">
        <property type="protein sequence ID" value="MST34941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="28482" checksum="D1AC9FC03EB8A2EF" modified="2021-04-07" version="1">MSSGVVQVGPGPIGSGARAAAAGAVTVTVNGAPLKGGGAGSTLLAGCSIDVGVSGLGAGAHRVGVTVSATEPSGSGAVVSVDEPEVTGAFDTGSRNLSTVLTGGFRRSGNGYHLRVTAAVDGVTIASAPYWLACGAVQHAGHAVQIALSVEWVDRAGKALAGPPKGIAKSYRLDATSSQGSGRCAYTARELVCRYRATTEDSTADAAAPPLGVRVSGLGTYVVVEHGLPSQWSPSLATVGQFAADPTIRQWWAVGEDAGVAPLVRGPSESGGGPPLIAHVVVNRQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE9</accession>
    <name>A0A7K0JYE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001343">
        <property type="protein sequence ID" value="MST34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="336" mass="36103" checksum="E46C87C2C483769C" modified="2021-04-07" version="1">MAGGPNRIAVVTGGSGGVGRATVREMAGHGYDVAVLARGRAGLDAAAEEVEAAGRRALAVEVDVADHDAVMAASRRVESELGPIDVWVNVAFEGSLAFFWDTTPEEYRRMTDVTYMGQVNGTWAALSVMRPRDRGAIINVCSAMSYRSIPLQSAYCGAKHAVKGFTESVITELLHEKSHVHLAMIQLPGLNTPQFNWNLNKMPEHPMPVAPIFQPELAARGIRYLAEHPRRRNMWVGVSTAMTILGERLAPWLVDLYLARTGVSSQQTGKEAPRLGANLDEPRDAEEDRGAHGAFDDKAHGHDPVLWMSTHRPAVLAGTAAAGMAGAALAGAKLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI8</accession>
    <name>A0A7K0JYI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001349">
        <property type="protein sequence ID" value="MST34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="5445" checksum="7FC19ECCD6F13391" modified="2021-04-07" version="1" fragment="single">MGPRPAEHDDRSIPDRADGDRVETALAAAARRRADVAARLPDEVEHPDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN1</accession>
    <name>A0A7K0JYN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001378">
        <property type="protein sequence ID" value="MST35037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="86" mass="8827" checksum="FDC49A0755ACAA3E" modified="2021-04-07" version="1" fragment="single">MPPTPHGRARPHPPARDLPALLLLLGVSASAFGRVFSGDGWVPAVLAPAVGVPLVDALAGRWLRAARAALIDVAALALIVVWGVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT8</accession>
    <name>A0A7K0JYT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001168">
        <property type="protein sequence ID" value="MST34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00032577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="35974" checksum="2CAD02D392E10831" modified="2021-04-07" version="1" fragment="single">LPKPCVDTGAGMERVLTMLQDVRSIWETDVIRPVIATAEALTGRRYGDDEAVDVALRILADHARSMAFLVSDGVFPTNEDRGYVLRRLIRRAVRFAHQLGVEQPVTAGLVHAVADVMGEAAPDLARNADYVAGVVTREEERFRSTLRSGMSILEAELAEGAALPGAVAFRLHDTFGFPIELTREIAAERGGAVDEEGFRRHLEDQQQRSREQGKGVALLPADRVEAYRALLADHGATRFVGYHATTATGTVLAVLDADAGAGEVEIFLDTTPFYAEGGGQVGDTGVIETDTGRARVLDTTRALPELTRHTAVLEDGELHPGQVASAAIDADRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV8</accession>
    <name>A0A7K0JYV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_18620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001178">
        <property type="protein sequence ID" value="MST34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="6">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="20737" checksum="8E8C8C6280B452B5" modified="2021-04-07" version="1">LVRAARRYDPERGIPFPGYAAPSILGELKRHFRDRTWSMRVPRRLKELYLQAREVRDEIVHRTGVSPTVPELAERLGCDPDTLLEAMEAGHNFHAASIDGLDEAAGRQLPFADGGFDGALDRYRLRQLLPLLTADERRILQMRFTEERTQSSIAAELGVSQMHVSRSLERIFAKLRSGMDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ13</accession>
    <name>A0A7K0JZ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001448">
        <property type="protein sequence ID" value="MST35122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="10703" checksum="F9A7FE3996C99483" modified="2021-04-07" version="1" fragment="single">RVRPLLAGICGSDLATLGARSSRWFESIVSFPFVPGHEVVGLDDAGRRVVVQPVLGCVPRGVEPPCPACAAGRTNHCVHLAAGHLQPGLQTGFCTDTGGGWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG0</accession>
    <name>A0A7K0JZG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001617">
        <property type="protein sequence ID" value="MST35317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="293" mass="32189" checksum="69A497C39AC1F70B" modified="2021-04-07" version="1" fragment="single">MFLKSLTLKGFKSFADTTTLEFEPGVTVVVGPNGSGKSNVVDAVAWVLGAQGPRTVRSAKMEDVIFAGTPKRAALGRAEVSLTIDNTSGLLPIEFSEVTITRTLFRTGESEYAINRVPCRLLDVQELLSDTGVGRQQHVIVSQGNLDAILTSRPEERRLVIEEAAGVLKYRRRKERSERRLEATEGSLLRLQDLLREVRRQLRPLEKQADAARRHDDVVAELTALRRFLAGRELAAIESRLSGAAERKDELVAAEAQLRDSLADLDAEVTTGEAELAESRERSDVADLAEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZK2</accession>
    <name>A0A7K0JZK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001356">
        <property type="protein sequence ID" value="MST35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="23058" checksum="FCC538774F76F913" modified="2021-04-07" version="1">AEGAAVATFDLPGTDGPGALHLALDVTDAAAVAAAVARVEDELGPIDVYCSNAGVAAGRGLGDDDDWDRSWAVHGMAHVHAARAVLPGMAGRGRGHFVVTASAAGLLLMMRSAPYTVTKHASVAIAEWLAVEYGGRGVAVHCLAPQGVRTPMVAGGDERSRRELEAGGAILEPGEVADAVVAALRSGEFLVTPHPEVRAYEAAKVADRTAWLARMRRLRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMZ1</accession>
    <name>A0A7K0JMZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000035">
        <property type="protein sequence ID" value="MST31308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="205"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="434" mass="44578" checksum="D0D5A262E85B39B6" modified="2021-04-07" version="1">MVPASASPSAATAVVSGLREVRGWAADLYRDLHAHPELSHQEHATAAKVAARLEASGVEVHTGIGGTGVVGLVRNGAGPTVLLRADMDALPIAEATGLDYASHATATDGTGDTVPVMHACGHDMHVACLLGAVHLLASRREQWSGTVIALFQPAEETGDGDRAMLEGGLAGVVPTPDVALAQHVLPAPAGLVGTHVGPTLSAADSMRITLHGRGAHGSMPQAAVDPVVLAAMVVVRLQTIVARETRPGEPAVVTVGSIRAGTKSKVIPDHAVLELNVRTYSDATRASILAAIRRIVDAECEASRCPAPADYELFDRFPLTSNDAETTGKVAAAFGSYFGERAGALPMQTASEDFSDIPDALGVPYCYWGIGGIDPDTYHRAEAEGRVAEDIPVNHSASFAPAIEPTLSTGIEAMVVAALAWLGAPAAGDGQGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMZ8</accession>
    <name>A0A7K0JMZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000038">
        <property type="protein sequence ID" value="MST31336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="6215" checksum="EC10C98C791B35E0" modified="2021-04-07" version="1" fragment="single">MRRLAVRYGTQRSQIGELWHPGGGQGPFPTVVLVHGGFWRAAATKRLMRPLAAALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR3</accession>
    <name>A0A7K0JNR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029603434" evidence="1">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11168" checksum="1FD228C8C74C6CB8" modified="2021-04-07" version="1">MKPSRPLLVASLASFLFAAPIVAMAAGGGVVVIAAGNVVSGMGLAVAVALWDTATQTRVSPEYLARVSAFDWLGSEALRPVGYALAVPLLDRGRAGDSLLAASTSSAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT7</accession>
    <name>A0A7K0JNT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_02660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000108">
        <property type="protein sequence ID" value="MST31632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="211" mass="20975" checksum="ED37B01D22AC7BC2" modified="2021-04-07" version="1">GDGLITNVSLVLGVAGASAAGPAVRLAGVAGLLAGAFSMAAGELVSVRAQDELMRREIDVEAEELRREPEEEQRELAAMYEARGVPSDDAATVARILSADHAIALDTHTRLELGIDPDAVGSAGAAGASSFFSFALGALLPLLPWFFVSGTAAVVASIVIGALAALALGAVIGAFTGRGVARTAARQLAAAVVAAGVTFAVGTLFGAHGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ2</accession>
    <name>A0A7K0JNZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar porter family MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_02980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000117">
        <property type="protein sequence ID" value="MST31692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="489" mass="51452" checksum="E021BD73D41E8C53" modified="2021-04-07" version="1">MATGAGQDRNVLSALDERTPSSFYWQLTVLATLGGFLFGYDTSNIGSALNFIPYHLTGFALGYLVSGASLGAAVGAICAGPISDRFGRKYLLVADAALYATGAILSAVTPDAAVLLAARTLIGLAIGADSAIATAYIAEYAPKGRRGALSMLQQWMITVGILLAYIVALIILRLAPGSAGSVDWRLILGLGAVPAVVGLAFRTQMPESPRWLLRHGRYEAVQRALATLGTEVTLEQVRSTAEVVHQRDTRRRSRHNWTPGVRRAVVVVAVFMAFQQITGINVPLYYGPHLLGPIFSGAHASLVASTIAGVEVTAIMTAVNVGSTYFGFRWIDRFGRRALSIGGYVGMAVFALVAAVGLAELSGTVRLVVIMLGLDLFIASFAIGVGGTGWTLQGEVFPTAVRGEAAAIAATVDWLANFALVEVFPVWHSAISLAGVMVCFAALCLLAIAFIGRFLPETKGLGVEEVIALFEDQQRRGGEGLDPGAPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP62</accession>
    <name>A0A7K0JP62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superoxide dismutase, Ni</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sodN</name>
        <name evidence="1" type="ORF">GHK86_02875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000112">
        <property type="protein sequence ID" value="MST31671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="15564" checksum="7710567710A4FAC4" modified="2021-04-07" version="1">MTVLSRLLGLADRVGAPAVAHAHCDLPCGVYDPAQARIEAESVKGCMEKFNGSDDATFKTRAVFIKEQRAELVKHHLWVLWTDYFKPPHLETYPQLHELFWKATKAAGEAKKTNDTAVADDLLAQIAEIDRIFWETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA1</accession>
    <name>A0A7K0JPA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="19112" checksum="F7F2114736923FC1" modified="2021-04-07" version="1">MPVRTARPSDVQALAALNAVVQHLHHVALPQQFKAPDGSAVEAYLAERLAKPETVALVAEDWGGTAVGYALGEVLDVQESALKWAGRLMHVQHIAVEPSEARKGWGTALMDAIEGEGARRGADEVRLDYWSFNERARRFFTALGYEPYNVRATKVLRPERRFRPTSADPAHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD4</accession>
    <name>A0A7K0JPD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000150">
        <property type="protein sequence ID" value="MST31830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="44"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="19656" checksum="C90D3397DB840902" modified="2021-04-07" version="1">LGVSPTPVREALRRLEQDGLVERVSARQLRVVERSPETLRELLLTAAVLRALEARFATAKITDAALDRMAALVDSLTPDGRRANAEYLRIAREFDQEIERAAGNPTLRGLIQSLSILGQGRRDLAVQSMRQRREVARSRIQGHRDILVALRARDPDAVEAAVRRHATTGVDLLLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE0</accession>
    <name>A0A7K0JPE0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B3_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3_4" evidence="1">
        <location>
            <begin position="73"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26725" checksum="C41F620A630B5BC5" modified="2021-04-07" version="1">MAEGGRGETFLARCSVDAGVFALRPDYRVVLVAAEGLVGGPTDETSDALLREAERTAQVLLADRPPEALASVAAWRDAYRAFGAKPQRTRNSLEALLRRVASGLPRVNRLTDLYNAISVRHLLPLGGEDLDRYAGPARLALASGDEPFETVTSGDVRFEHPEPGEVVWCDDEGVTCRRWNWRQTHRTRLGEDTTAALFVLEALDPMPDEALAAAAADLVDHLNAYAPQAGVARRLITAPSRGARRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK8</accession>
    <name>A0A7K0JPK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acs</name>
        <name evidence="5" type="synonym">acsA</name>
        <name evidence="9" type="ORF">GHK86_03930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000160">
        <property type="protein sequence ID" value="MST31875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="92"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="536"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="393"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="417"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="655" mass="72064" checksum="7153A1DD951E10A8" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ11</accession>
    <name>A0A7K0JQ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific DNA-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015855">
        <property type="entry name" value="TypeIII_Mtase_mKpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="85"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="608" mass="67194" checksum="623613D432F17939" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ19</accession>
    <name>A0A7K0JQ19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="485" mass="54137" checksum="F8BF7D45C1DD3AD3" modified="2021-04-07" version="1">MRRTSHPAATFSTAYGLTLTATDDWFDPTLHTDTALFVDPFLMFSEHQPPWSTVEQRLVDFFNEALLRVAASRSGARLERETAAAMLSFPEPAALCLGYGNKTIFGLGSGAGLGQAMLQAANDAITAGITNITEFGDLLLFGEGMGCDRVSDVVGNVIKPDFIAYTQAVATRHGIPMTPYLLPHVGYDHQGHRWRREYVNLPANPCWEKTPVILVPRRFLDDLPGLDDDAFWEWVYGSHNEQLRHDLNLAIGSKLKRREIIALAKRRSTLRVRYGQLYVAASRQQPPKPYDLERDPKGLVLPKRVAVSLTQVEPPSSPEGFADYIFSLANDVKRLVEGGLWRYFWDGNRPRGEANAQGLFRAAVTLACRDRDIDVSPETNAGAGPVDFKFSQGWSRRSIVELKLASSSSFWNNVEEQPPAYMDAEGISCGVIVVFQLEDKHCTEAFTAQAQDAVDRAAKERKLDYRIVFVDTRQKPSASKRKRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ27</accession>
    <name>A0A7K0JQ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000111">
        <property type="protein sequence ID" value="MST31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="67"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="259" mass="28385" checksum="264B9CD537F77316" modified="2021-04-07" version="1">MTDSVDPVAYNRAAWDREVESGNEWTRPVGPEVIAGARAGDWSVVLIGYQAVPRAWWPDDLAGMEVLCLASGGGQQGPVLAAAGAAVTVFDNSPRQLERDREVATREGLEVRTVLGDMRDLGVFPDACFDVVFHPVSNVFCPDLLPVWREAFRVLRTGGILMAGFMNPDVFIFDIPALEESDELVVRHPLPFSSLDLPDDERRRSYGDGPIEYSHTLTEQIGGQLAAGFTLTHFVEAPHHVGATARYMSGYFATRAIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ46</accession>
    <name>A0A7K0JQ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000207">
        <property type="protein sequence ID" value="MST32078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="331" mass="33936" checksum="B2F9239CFCF43B67" modified="2021-04-07" version="1" fragment="single">MVDGAADGRPAVVAGRYRVLRAAAGGACTLELHGYDERLGRAVSLEVLRPEWRSDAGLRASFAAAARRAARLQHHHVLRVFDVVSDDGAPAVVTELAAGGTLADRLRGGILDEAAAQRLVLAVLAALDAAHGTGLLHLDVTPSNVLFDEHGTVEVARFGVLDALYRAVRATPGAGAEAAAEGPDRLVLPVPMARQAPECRAGAEPTAAADLWSVGALVYRALTGSPFSTGRPADAPLSPLASLASLRPGVDRGLAAVVAKALDPRPEHRFASAVEMAAAVAPSRRSTTVAPALVPADPAPPRSDDRETDRTGPVGAVRTGPVGAVRTGPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC1</accession>
    <name>A0A7K0JQC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000221">
        <property type="protein sequence ID" value="MST32142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="11064" checksum="C50805FC4C4A5968" modified="2021-04-07" version="1" fragment="single">MIGHAPPPPGSTMQAAVLRQVGAPLSLEEVDVPHPGPRQVLVRVEACGLCGIDVRIAREEWPGRLDLPRTLGHETVGRVAEVGSEVSHLRDGDRVVVPRLAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH0</accession>
    <name>A0A7K0JQH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000236">
        <property type="protein sequence ID" value="MST32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="21323" checksum="0DEE815CC83FF03F" modified="2021-04-07" version="1">MTTTPAKRAAFRSFAESTAEDWAIITPQLEVTQAAVPDRVLEQLRYLGSDHGGYPVDRLEHSLQTATRAERDGRDEEYVLCALLHDIGDALSPYNHEAIGAAIAQPFVSEANHWMMAHHGYFQGLYFWHHLGADRNARERFRDSPYFEHTEEFCAKYDQVAFDPDYRSEPLEHFEPLVRARLASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ3</accession>
    <name>A0A7K0JQJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="42005" checksum="732ECCF3A01F1DE8" modified="2021-04-07" version="1">MPAFVFPGQGWQRPGMGRQWTDHPSWELVDDASEAAGRDVAHLLLDADADELTETRNAQLATFTLSLVLLDAVERLGIEPTAAAGHSVGEYAALVGAGVIGFEDGVRLVAERGDAMQAAADAEPGVMAVVAGSDAETVDIACRLADGPVWLANDNSVTEVVIAGEGDAVERAGARALELGARGLRPVPVGGAFHTPFMAPARNRLTKALAEVVFHRPEIPVVANVDGRVHTGATEWPTRLLAQLTSPVRWRQSVLRLGALLDERAERERLFVELGPGSSLSRLAGQTLPGIRSLSISAPDHLDQLVDAIAGDTPLHAFAAGHHGEHLYVSERVVIAPAAGVFEPAPGLDTAETLVEVGSLLGAVSGADVRSPFAGRLMGMLAAPGERVQTGQPVAWLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ8</accession>
    <name>A0A7K0JQJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029606637" evidence="2">
        <location>
            <begin position="32"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="293" mass="31207" checksum="387D6EB8683F8F2E" modified="2021-04-07" version="1">MRNSQPVPAALALLLFAVLAIGAGRLPEAGAAGRPAPATVRSPLPTGSRRLPRPTPGCRQRALLPAYFYPGPAWRAELAAVQPGSAIIVNPDSGPGPSRNADYVQVVDAARSKGALLWGYVDTRYGAVPPASLAAQVRAYRRWYGITDIFFDDVSSLAARVGYYRTANRIVRSAAPHASVILNPGDYPAPVYASLGDVLVVFEGDSSRYTKAYPPAWTRRHPPGMFVSLISAVPPSRLGATLALARARRSGWVYVTPHADDSDLYEQLPAYWSAELHVLAAAPPMGPAPTCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW5</accession>
    <name>A0A7K0JQW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="12319" checksum="B574FBA668CFAEAB" modified="2021-04-07" version="1">MARRVAGHTREARETLRAAYDGAGHCGAAVLAEQAHAELLASGARPRRQQLTGLRSLTASERRVCELAASGLTNTQIAQRLFVTRSTVEKHLSHAYDKLGLASREGLTDLLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY0</accession>
    <name>A0A7K0JQY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000191">
        <property type="protein sequence ID" value="MST31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="33032" checksum="23FFC373BBAAD7C7" modified="2021-04-07" version="1">MRYRQLGDSGLTVSVVGLGCNNFGGRIDLDASRLVIDRAIDLGVTLFDTADIYGNRGGSEEVLGEVLGRRRDDIVLATKWGNEMGTGDREARGGRRYIRRAVEASLRRLRTDHIDLYQLHNPDPKTPIDETLAALDELVDEGKIRYAGSSNFAAWQVADADWAARTHGWERMISAQNHYSLLERDVEGELLPACRRFGVGILPYFPLANGLLTGKYRRGEPRPEGTRLAGREIDEATFDRIEALEGFAAQHGHSLLELAFAGLLAHPEVSSVIAGATRPEQVEANVAAGEWQLDAGELPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR12</accession>
    <name>A0A7K0JR12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIGR04053 family radical SAM/SPASM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_06455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="392" mass="41222" checksum="2B89FE8AE47EB442" modified="2021-04-07" version="1">MPSSAPTPTADGNIRRLRFDVSARPFLVLLELTRACDLACRHCRAEAIPEREADELTTSEVAAVLDDLAALGPPRPRLVLTGGDPLRRPDLDQLVWHASGAGLSVAVSPAGTPRATPDRLGALRAAGAGAVSFSLDAASAPAHDAFRRVDGSFHWTLAGCEAAHAAGLRLQVNSTVTAATINELPALARLVSELHVGMWSVFFVVPVGRAGADQALSAAQTEDVLRFLQAVADWVPLKTTEAPAFRRVVSQPATSRPGPLYRALTRRLDEVWPVAARPSVRRRAPLAVGDGRGVVFVSRRGDVQPSGFLPLVAGNVREAPLTTIYATAPLLRALRDGAARDGRCGRCEYTDTCGGSRAQAFARTGDPLAADPSCPYEPGAGGSPLHAAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR44</accession>
    <name>A0A7K0JR44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="439" mass="46325" checksum="F3C069F85587CBD3" modified="2021-04-07" version="1">MEGSVREPRVLVVGGGFAGFECARRLARPGGPAVTLVSPEDYFLYTPLLPEVAGSVLDPRHAAVPLAESLPGVRVLRGVVADVDLDEHTAEVAVPDAAGGRTERWDRLVLTPGSVTRVLDIPGLAERARGLKTLAEAVYLRDHLLGQLERSASLPPGDPACRACRTVVVVGASYAGTELVAQLRGLAHDAALHYRFPASDLHVVLLDVAAEVMPEVGSRLGRRALEVLRSRGVDVRLETTLRSVQSDTVTLSDGQTLPCGTLAWVTGVTANPLVGRLPLELHQGRAVVDEHLQVPGRPDVFAAGDAAAVPDPTEPGSVTPPTAQHATRQGRTLARNVLASLGGDRLTPYRHRDLGLTVDLGPGFAVANPFGVPLSGLAAKAVTRGYHLAALPRRANRLQVGLDWLLMATSPRPLVSLGLVHPERVALDGGQREAAAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR45</accession>
    <name>A0A7K0JR45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">panB</name>
        <name evidence="10" type="ORF">GHK86_06750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="31361" checksum="B1023FF9580978E7" modified="2021-04-07" version="1">MATTVTAPEVRARKGGDRLVMVTAYDAPGARIADAAGVDLILVGDSVANNVLGYEDTLQVTVDDIAHHVAAVGRTRPRALVVADLPWLSYHTGVGDAVRNAGRLIRAGAGAVKLEGGRKRLPVVEALIDAEIPVVGHLGLTPQSVLAMGGFKVQGRAGQAVRRLLDEALALADAGVFALVLEGIPDRVAELVTDSVAVPTIGIGAGAACDGQVLVFHDLLGLGDRPVPKFVRAYAALGRDATEAIARWAADVRSGAFPGDAESYHLPAETARELGLEPHPSAPGPAEPAPGVPSSRAPAPTGSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR67</accession>
    <name>A0A7K0JR67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000210">
        <property type="protein sequence ID" value="MST32089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="259" mass="28547" checksum="ED914451D16E2FDB" modified="2021-04-07" version="1">MRRLQELEGRGEQRPFFTSDLSVNEFLLVKEAGFDPRGLVYGSSIYHIGLQRRNWSSNMELEKLTQAMYTARELAMARMEAEAEVLGADGIVGVRLDINYYDWGKHSAEFIAVGTAVSARGAEGSWRTDEGKPFTSDLSGQDFWTLVQSGYLPLGLVLGTCVYHVAHRGPMAAALQSMANRELENFTQGLYDARELAMTRMQDEALRLGAEGIVGVHLEEKSHFWGSHVIEFLAVGTAVRPAPGAAGPGHPQLMLPMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA0</accession>
    <name>A0A7K0JRA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">GHK86_06925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000296">
        <property type="protein sequence ID" value="MST32452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="127"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="466" mass="52226" checksum="4F351C4FCF53D46B" modified="2021-04-07" version="1">MATAELDLGRYKLGWSDIEDFYVFKPKKGLSEDIVREMSWMKGEPEWMTSNRLKALRRFQARPMPSWGGDLSGIDFSDIFYYIKPTDKQVDAWDQLPDSVKATYEKLGIPEAERKYLAGVTAQYESEVVYHKNREDLEAQGVLFCDMDTALKEYPELVKQYFGKVIPANDNKFAALNTSVWSGGSFIYVPPGVTVDMPLQAYFRINAENMGQFERTLIIADEGSQVHYIEGCSAPVYTSDSLHSAVVEIVVKPSARVTYTTIQNWSNNVYNLVTKRARVEAEGHMEWIDGNIGSRLTMKYPAVWLVGPKASGEVLSVAYAGPGQHQDAGAKMVHAAPETTSTIISKSISKDAGRTSYRGLVEFKEGATRSKSFVRCDALLLDDISRSDTYPYIEVAEQDAQVGHEATVSRVGEDQLFYLMSRGLSEQQAMSMIVNGFIEPITRTLPMEYAVEWSRLIELQMEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF7</accession>
    <name>A0A7K0JRF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_07150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000313">
        <property type="protein sequence ID" value="MST32497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="333"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="403"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="458" mass="48288" checksum="F1919272AA660B10" modified="2021-04-07" version="1">MQAADSLLDLIGNTPLVRLDRTARDLSCTLLAKLEYLNPGGSVKDRPALRMIEAAEREGLLGPGGTIVEPTSGNTGVGLAIVAARRGYRCIFTMPDKIAEEKRALLRAYGAEVVVCPTSVPPEHPDSYYSVAERLAETTPGAFRPNQYANPHNPEAHVRTTGPEIWEQTGGRITHFVCAIGTGGTISGIGRYLKSKNPAIQVIGADPEGSVYSGGTGRPYLVEGIGEDFWPATYDREVADRVIMVSDRDSFLTARRVTREEGILVGGSCGTAVAAALEVGHDLGPDDVVVVLLPDSGRGYLSKVYDDGWMADHGFLRAGGDDLAAVLGRKAVDLPPLVHVHPDETVRSAIAILKEFGVSQMPVVQAEPPVALAEVVGTVSDRLLLQAALEKPETIDGPVSAVMESPLPTVGTGEPIDLAAARLAGGASAVLVMDEGRPVGIVTRSDLLEYLAGPPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ5</accession>
    <name>A0A7K0JRJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000325">
        <property type="protein sequence ID" value="MST32537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="7714" checksum="CEADED44DBF10B81" modified="2021-04-07" version="1" fragment="single">MPIAAGAVPSLGTGDAEVEEIVARRAVTPLFQPLVHLSSGETVGFECLARGPEGSSLRAPGALFAAAARAGLLGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN1</accession>
    <name>A0A7K0JRN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000337">
        <property type="protein sequence ID" value="MST32592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="11539" checksum="BB64668CF5D25B1F" modified="2021-04-07" version="1">MATTPPAPDEQRLDAAERRALENEIAALRERLRHREAALTALNRRLVALERFDATQGAPVPGDAEARARAAEEELARVLNTRTFRYTASARGVYRRVRRLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW2</accession>
    <name>A0A7K0JRW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000352">
        <property type="protein sequence ID" value="MST32657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="15349" checksum="DA3A7A4AF9A56B6E" modified="2021-04-07" version="1">MRDPRPGLGWSRRRAQTRTRYERWMASQAWRARRRAWLAAYVTRTGVQPRCAVCDRPWTLTDGELHHRSYRHLGAETDTDLVQLCVGCHQLLHRILEGHPGWLRQAGRPHATDVIIARLRAANACPRPEEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW5</accession>
    <name>A0A7K0JRW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000362">
        <property type="protein sequence ID" value="MST32688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="14211" checksum="DE377A495A012D28" modified="2021-04-07" version="1">MHLMGMRYGVVIVAGAGVALVLVLGGLAAAWRRRRLRGRRQAPPPFEPRPGFRILYDADEIEHSAAKAANRDYELAMTLLLRGSSHMPSMASAPDGGVGGSVSRIRTAPATSEMVRRIGRLPAAHGGAAGTSLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY1</accession>
    <name>A0A7K0JRY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000364">
        <property type="protein sequence ID" value="MST32695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIP" evidence="1">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="7466" checksum="5A8A6024D777C0CD" modified="2021-04-07" version="1">GAGEPGVQLLDALESLGLPDGGAGGAAYVGGEAKAVAAIRGWLIGHGWPAEAIAAKAYWRADKSNQDHGEPEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS26</accession>
    <name>A0A7K0JS26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000376">
        <property type="protein sequence ID" value="MST32742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="411" mass="41761" checksum="BF1E3E96FD54AC43" modified="2021-04-07" version="1" fragment="single">MLVDVKPAVVTARPGVPVHLAVTVTNDGTLISEHRVQVLGVDPAWVSLDRPDLKLFPDASGTVLVTVTFPTGIPAGSRRVDVEVVELTPPRERVVVPVDLKVPADLRLGLRVDPVSATGGRQSVVAVIGENRGNAPIDLQLTGLDDEGVVDFAFDPPDPVLGPGEQLIVKARLRAPRPLFGSPKIRPYQVQAGPASAPTVAQGAWVQRPRFSRGSLTLMGLLATATVFAVVVAVALSQVVSTSNANSNLALQAAAAQASDTAGSGRAQIGGTVTSVVTGAAVQDVTVVLYAASATSSPVVSTTTDQAGGYLFQGLPAGGYKLHFTSSAASSSQFGGLWYPDSLTVSGARTVTVGPGAKDTHVDVRFEGVPASISGRVTGSGVSGAQLTIEAAGSPAVATGSAAAAWRGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS35</accession>
    <name>A0A7K0JS35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000379">
        <property type="protein sequence ID" value="MST32752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="36" mass="4093" checksum="3B08485244FCBA89" modified="2021-04-07" version="1" fragment="single">MWWVRRDLRLADNPALAAAADAGVVLPVFVLDDRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS74</accession>
    <name>A0A7K0JS74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliW</name>
        <name evidence="4" type="ORF">GHK86_08590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000386">
        <property type="protein sequence ID" value="MST32777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14155" checksum="9926ECB87E5C1BB2" modified="2021-04-07" version="1">MTDVLMPVLSTIRFPQGIPGFGTLREARCEPWGGDESPFVLLSAEEPSVRFVVAPPHIFFPDYRPEVPADIRADLALADGEGLLLVILTLGSGPADTTANLLGPLVVNPATGRARQAVLNAAEWSPRTPLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS87</accession>
    <name>A0A7K0JS87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000395">
        <property type="protein sequence ID" value="MST32808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029752408" evidence="2">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="21984" checksum="D195A07971E61F6D" modified="2021-04-07" version="1">MKRWIWPAAAAAAAVGLAGCGSATNTGAASGSTTSTSATTAPASSTGTTGASGTTATSATSGTSGTSGTTSSTSGTTSTTAVSGVAECTTSQLSGTLTDANGAAGSVYYHLVLTNKGSGTCFVQGYPGVSFVTTPEGAPVGAAAKRQADPSVSGTPRVTLTSGSSAHSILRIVAAGNFPASSCGPTKVPGLRVYPPDQKASLYVTSQQEACSNASTNVLFVEPLVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA7</accession>
    <name>A0A7K0JSA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000395">
        <property type="protein sequence ID" value="MST32807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="25640" checksum="B6FE8606120147DC" modified="2021-04-07" version="1">MELRRQLAHLERVLGADLPGAQRRAREVVGEERWPVTLAVAVAIVLQATLSGRLALGPSGLIVGLEAALGIALLIANPRRINRRSRVLRVLSIALVALTSLANAWSSYALIRAIVVGDHHLTAVSLLASGGAVYLTNIIVFGLWYWEWEAGGPVERAHSGRPYPDFLFPQDSGGAPVPPGWAPTFADYLYVSYTNATAFSPTDTMPLSRWAKLLMMVQSAVALVTIGLVVARAVNIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB9</accession>
    <name>A0A7K0JSB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2662 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000405">
        <property type="protein sequence ID" value="MST32841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="23736" checksum="E974669E9FDF14CB" modified="2021-04-07" version="1">MGLQQFERRLERVVEGVFARAFRSGLQPVEIGRRLTREMDLQRTLAPRGTLTPNHFVITLSPEDADRFAPIEDELVTELVSVARDHAAREDYVFIGPVIVELEVDEHLVEGTLDLASEMTRTGGGATVVLGDGRRIPLGSNPLVIGRLPECDVVLADGNVSRRHAEIRPHGDGWVLADLGSTNGTRLNGFRLTAPRELRSGDEIAVGNSLLHFEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI4</accession>
    <name>A0A7K0JSI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF222 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="336"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="411" mass="44879" checksum="C2F44505BE2CF63F" modified="2021-04-07" version="1">MGSVGGGYRPGRALVWWWSVWVAGRVRGGRGVAMATSVLGGEEQVGAAGSELGSWLVAQACGACSWEAGWLAALVRFDRAKQWAADGALSCADWLIGRVRLARSTAFEKLRVAHELARRPVVAEAFAAGEITYCAVREITRATGTDPAIDEVLVELARTATVLDVRRAVRRVLLLAEQDREPQERQATRGVRIVANGDGTTRVHAVLSDLEAAELAAALDTLMDHSSGVSQSEESTRADGSPAALADWEDRPWHHRRADALMDLVRAHTARLCGADRYLVHVVVLTAGGAEILGGEPLDPATTARIRCDCSTVTHWVSETGQPLHLGRKQRSWNLAQRRAITVRDRGRCRFPNCERTHTDIHHVQPWEHGGPTDISNGILLCPHHHTLIHDGWTITGDINHTLVFRRPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP6</accession>
    <name>A0A7K0JSP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_09630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042518">
        <property type="entry name" value="SirC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="7">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="24215" checksum="27527B5F046111B2" modified="2021-04-07" version="1">MATLAAEETAVPTTVDPSEEIAASTAGHYPVSLVIEDQPCLVVGGGPVAASKVRGLRIAGARVTVVAPSVVPVIERLAVQEPAVVVHRRTYRSGETAGYRLVITATGVADIDAAVARDATSRGIWVNSADDPANCSFILPSVHRDGRVTVAVSTGGASPALASWIRRRLARCCGQDMGALAELLGQARKRVQASGRPTNSVDWQGLLDGCLPGLVNVGRLEEARRLVELLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST2</accession>
    <name>A0A7K0JST2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000447">
        <property type="protein sequence ID" value="MST32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="56" mass="5776" checksum="83333BC933011452" modified="2021-04-07" version="1">MTVLYGAAAALVLAQLVGIYGLVTRKADLVFSLLMVVLVVIAAVLAVAGINALRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ8</accession>
    <name>A0A7K0JSZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000464">
        <property type="protein sequence ID" value="MST33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="358"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="402"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="697" mass="74960" checksum="66049A8999736A28" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT34</accession>
    <name>A0A7K0JT34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">GHK86_10345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="WJHE01000491">
        <property type="protein sequence ID" value="MST33116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="22608" checksum="1E019B90DA792609" modified="2021-04-07" version="1">TADLDRVARDVLERRGARSNFLNYHGFPAVICTSPNSMIVHGIPGDYRLEEGDIISIDCGAIVEGYHGDAAFTMGVGTISGEAEKLLRVTEESLWAGIAKLRDGNRLHDVGLAVQQVAEGAGFSVVREYVGHAIGTAMHEEPQVPNYWPGTPGPKLKSGMVFAVEPMVNVGGPETVTLDDGWAVVTADGSLSAHFEHTIAVTDDGPEVLTVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT49</accession>
    <name>A0A7K0JT49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminomethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000382">
        <property type="protein sequence ID" value="MST32764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="1">
        <location>
            <begin position="10"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="31552" checksum="33350CF19B0507A6" modified="2021-04-07" version="1" fragment="single">MDVTEMTGFHKAAEAAGARFVEYEGYWLPTAFGDDILDEYRACRQGVAVIDLSPLRKFDVSGPGALALLQATVTRDLTRLADGQVVYTAMCNDEGGMLDDGTVFRFDGQRFRWVGYTDDDGPWLRQQAERLGLDVSIEPTTSRVHNVAVQGPASRDLLRAVAWTPSDRPSLDDLTWFRFTEGRIGGETGPAAVISRTGYSGELGYEIWCHPDDGAAVWEAVWSAGRAHNVSGLGLEALDPLRIEAGLIFKGYEYEAGVQDPFEAGIGFTVTASKTDDYVGRDALARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT72</accession>
    <name>A0A7K0JT72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF302 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000496">
        <property type="protein sequence ID" value="MST33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="2">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="134" mass="14339" checksum="D7E462A00B1F0C1F" modified="2021-04-07" version="1" fragment="single">MAYTRSITLPLPFEEAVPAVKAAFQGQGFGALTEIDVRATLHEKIGEELEPYLIIGACNPRLAHRALGADPQVGALLPCNVVVRQADGEVVVDALDPSVMIGLSDSPELRPVAEEADEWRCHGRPDGDAADGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT84</accession>
    <name>A0A7K0JT84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="26297" checksum="8D34C24070A6325D" modified="2021-04-07" version="1">MARNQRLADAITQRGWDLRRFAADVGVDAKTAERWVTQGRLPHPRLRDRSAASLHVPAGVLWPDAAAPAVGIGELVALYPTRTDMAPATVRSLVAGAEEHIDVLAYAATWLWDAVPRFVDTLVHKLEGGCDVRICLGDPDSSAVALRGEEEGIGDALAARCRIALTYAAPLAKAQPSAVRRSDKILYASLLRFDDEVLVNTHLWGNPAACSPVLHLRRADDRGVAATALESFERVWAAAQPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT89</accession>
    <name>A0A7K0JT89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000504">
        <property type="protein sequence ID" value="MST33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="9303" checksum="AD12BD056A35F7BB" modified="2021-04-07" version="1" fragment="single">MASQSGIVVGTCSWTDRTLVAETDWYPKRSMSAAERLAFYAEHFAVAEADSTYYFPPGPDLTRGWAERTPAGFTMDVKAYALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE1</accession>
    <name>A0A7K0JTE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000524">
        <property type="protein sequence ID" value="MST33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="14621" checksum="8E09C770DEC6FBF5" modified="2021-04-07" version="1">MESPQRARRRSVRLPADPTSAAAARRYVQDWLADLDRQEPSVCDAAVLCVSELLSNALQHTASRAVTLTISRDDAGMRIEVGDESSVDPVVRVAPDGERGRGLGIVSSLTCGWGVEHHADDGKSVWATIALDAGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN1</accession>
    <name>A0A7K0JTN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000553">
        <property type="protein sequence ID" value="MST33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="227" mass="23784" checksum="57524E5A2FF65AF9" modified="2021-04-07" version="1">MAHDDVVPAREARRALRPTGTDLAPAWRGRLHRWAAVVSAPAAVALVLHRPTPAVGGYAAGLVALFAVSAAYHLAPVSPGARQRWRRADHAVIYLFMVLSYIPFCQQAVGGTLGAVLLGLALAVGAAGLGVKLFGFRRSGVIGAVLYMVLGWMAAVALPGAVGTLPGVELGLLAATGLLYTGGAAVFARRWPDPLPAVFGYHEVWHACVVVAAACYFAFVWQLPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY1</accession>
    <name>A0A7K0JTY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000580">
        <property type="protein sequence ID" value="MST33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="173"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="42643" checksum="77F8536A9175AD8F" modified="2021-04-07" version="1">MIDHHVHGVVRSVLPRPAFELLINEGGWVAPPGTSHFDSSLGAAIRRWCAPVLGLDPLCPPDTYLGRRAELGDEANRLLLRAAAGAGLVGAYVDTGHRSGEVCTPEELGALAGVPAWEVVRVESVFEEAAAAAAAEGRVAELPDRWAALLRRRALTAVGLKSVVAYRHGFDLDPTPPAPGEVVVAVERWLQDAVAGAPGDRPPRLRVADPVLLRHILWEAAAVGREQRLPLQLHAGFGDADLDLHRVDPVVFTPWLRAWRSLDLPVVFLHCWPYHRQAAYLAAIWPSVYFDLGASLNYVGARAPAVLAEALEVAPWSKLLYSSDAFGLAELVHLGAVAFVRGLDAVLSRWVESGELTAVDADRVRSLAGAGNARRLYAGAPGLRASGAGPAGTPGPAAPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY4</accession>
    <name>A0A7K0JTY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000580">
        <property type="protein sequence ID" value="MST33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="141"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="490" mass="53919" checksum="D9AC6C8067BFD7FC" modified="2021-04-07" version="1">MAERGVGKQGFVAEHGLLTPEQQEAGERSLALVEQHGLRTVRMVWVDQHGAPRCKFMSAADYAASLRSGIDFSGAVLNLDTTNHVFALAFAEGGGLGIPELTGFPDMMLVPDPTTFRVLPWADRTGWVLTDAYFDNGKPVPLDTRHLLRRQVQQAKDAGFDYLSGLEVEFYVLRREAPGRIELDQTGWPPPVPAVSAFQQGYQYLSEVRLAGVNDLVERLRDAMLEVGLPLRSIEDEWGPGQLEVTFDPLGGLGSADAMVLFRGAVKQICEQQGLHATFMCRPGLPNFFSSGWHLHESLVERATGANCFVSDDGAQALSPTGRRFVAGLLEHARGMTVFTTPTINGYKRFKPYSFAPDRVTWGAENRGTMVRVQGGPGDKGTHVENRLGEPAANPYLYLAANIAAGLDGIRRELDPPPAAGPDPYSAEAPMLPTSLWEAVDALEADPFFASPDVFGEGFVRYLALMKRSEIGRFLSEVTDWEMREYFEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU61</accession>
    <name>A0A7K0JU61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000612">
        <property type="protein sequence ID" value="MST33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCV_T" evidence="1">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="2">
        <location>
            <begin position="277"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="366" mass="39732" checksum="2289ECD04A17786C" modified="2021-04-07" version="1">HGAKPLVAGQWIRPDHYGDPDAEVATVRNKVGIIDVTPLGKLDLRGPDVPKLLNLLYVNKWSKLAVGSVRYGVMCAEDGVVLDDGVTGRLAEDRWVMSTTSSGAATVWEWAESWLQTEHPDWQVHVTPVTTAYASINIAGPASRELLGRLCTDVDLSGEAFPYMQVRAGTIAGVAGCWMWRIGFTGELSYEIHVPAGYGLHVWESLLDAGADLGVGAFGIEAQRIMRLEKGHFIVAQDTDGLTKALGAGLDWLVKLDKDDFAGKPELAWQAGEHYQRLVGLQPLDGDIVPPEASQIVAGETRIVGRITSSRRSPTLGRSICLGFVEPDLAAAGTIVTVLLPDRRRIPARVMEHHAHYDPEGVRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA5</accession>
    <name>A0A7K0JUA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_12495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000632">
        <property type="protein sequence ID" value="MST33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="25018" checksum="3B64A91D01E237DC" modified="2021-04-07" version="1" fragment="single">LITVPGDRPNVARTERELLVAFPGPAGWVFPVDGVGFELAPGEMVGIVGESGSGKSLTALAVAQLVDPGGEVAAGTLRFDGVDLIAAGAGARSLLGTSLSMVFQDPLSALNPAIRVGPQLAEVTRVHQGQSKAAALARAVDRLGAVRLPNPARRADQYPHELSGGMRQRAVIGMGLMGAPKLVIADEPTTALDVSVQSQILDLLQSVRDEQGAAILLISHDIAIVGQRCQRVLVMYGGRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF5</accession>
    <name>A0A7K0JUF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_12755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000650">
        <property type="protein sequence ID" value="MST33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="213"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="387" mass="41436" checksum="87C29EE09DB02FBD" modified="2021-04-07" version="1">GALAANRAQVVGLTRLGERVTGAVVRDLESGEELVVRARRVVNATGVWTDDTQRLATDRGAVRVRASKGVHLVVPRDRIRSEVGLILRTETSVLFVIPWGRHWLIGTTDTDWDLDRAHPAASAADIDYLLEHLNAVLQTPVTRDDIEGVYAGLRPLLDGESEATSRLSREHTVVTPVPGLVVVAGGKYTTYRVMARDAVDAAVHGLPAAVPASCTDQLPLAGAEGWPAVRNSAPRLAAESGLHPDRIEHLLGRYGALVQDLLELVAADPSLAEPLPGEGADDYLGAEVVYAVAAEGARHVEDVLARRTRISFEAFDRGVFAAERVARLMAPLLGWDAEREAGEVAHYRARVAAERRSQQAADDRTADATRLGAPDVIPTVPLGAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL6</accession>
    <name>A0A7K0JUL6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">GHK86_13080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="WJHE01000672">
        <property type="protein sequence ID" value="MST33647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="144"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="354"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="56"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="560" mass="59642" checksum="A256FEAE6330B9CA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN2</accession>
    <name>A0A7K0JUN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000679">
        <property type="protein sequence ID" value="MST33660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="7414" checksum="37A16285F25D31BE" modified="2021-04-07" version="1" fragment="single">MSPAARGAAPRRLVHGLVRTLEVLLATAIGVGGVYGGLHLYDTLQRHPGAARTGGRAAHVAPRQVASAAVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN6</accession>
    <name>A0A7K0JUN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">atpH</name>
        <name evidence="7" type="ORF">GHK86_13035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000670">
        <property type="protein sequence ID" value="MST33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="18650" checksum="0A9C258DD3C0C22F" modified="2021-04-07" version="1">EGIDGQGPLSELEDQLFRFERALDASPELTQVLTSRDLPVEARAGVVHDLLAERALDATRRLATYLTHVGRPRDYLELLQALVARIGEEAHRRVALVRSAVALTAEQEDRLSAALSRIVGQQVDVRVTVDPTVLGGFVATIGDTVVDASVRHRLDLLRERLTTLPEATTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS0</accession>
    <name>A0A7K0JUS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000687">
        <property type="protein sequence ID" value="MST33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="34069" checksum="C25DDB8158D692DC" modified="2021-04-07" version="1">LAASAACWLGCALQAALVATRRRLPRWPAAVPAAAGLAALLRSTSAASTDVPLSAALLAGVAAALVVAGAGLELRHLLRFLDRRDFGLRMDLDSARREMEDQRAQLHEQLHDLRNAVSALRCADTTLRTRAEHLDPAARAALADAMSLELARLQVLIEPGRRAVVADFDLRDALEPVVTAERNLGAAITLSVDRVRAHGDATGLAQAVQNLLVNARRYAPGAHVLVTAEPCPGSGRVALLVSDDGPGIPEAERDRIFLRGARGSTAAGTAGEGLGLHVARRLVAASGGQLSLLDRPAPGACFLIDLPAPGGSPDRSAASSARALSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV7</accession>
    <name>A0A7K0JUV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000703">
        <property type="protein sequence ID" value="MST33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="24851" checksum="45F8C25CC291D814" modified="2021-04-07" version="1">MSAIAASTTDETDPRRLQILRAALDVIADRGYGDTRIADVAERVGVSPALVMYYFKSKDRLLAEAIRYAEDLWYAEGTRRIEKIPTAAGRLEELIRLTCLPQQDVGLSESWSLWIDLWAQSVRRPEVGTVRQEFDEHWRQTVRAVVEDGQRAGEFADLDAEEAAIALCALLDGLSIQIALRDPVVTEERAFANAMSFASAMLGFSWERPAAKRRRRRPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY3</accession>
    <name>A0A7K0JUY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000706">
        <property type="protein sequence ID" value="MST33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="24514" checksum="65ACCECFE23A0C7E" modified="2021-04-07" version="1">MTAPGGVGGYNRSCCSASRYGTHVPFVNPFPRSVRPVSTPSPPPDPARPRRADARRNRQRILEAAAAVFADEGLAVPIDVIASRAGVGVGTVYRHFPTKDALFEAIVVDRFDQLLCRVDELSERRDPGEAFFRFIAEMGVLGTEHKDLIEELGRREADAPGLKADVKAHLEAAVGRLLGQAQACGAVRKDVDVTEVMGLLMGTCMAAAHIGSPNLVRVLSDGLRPAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ6</accession>
    <name>A0A7K0JUZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000697">
        <property type="protein sequence ID" value="MST33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="21365" checksum="3745F033728FB387" modified="2021-04-07" version="1" fragment="single">MLALLNFTHFVATSGYAAIFLLSVLQSCCVPTSSELTLGFAGVLAAEGKLSLPGVIIAGAAGEIVGAYIAWAIGYFGGRPFVERYGRYVLMTPEDLDRAEGWYQRHERFGVFGSRLLPVIRNFVAVPAGVAEVPLVRFGVLTAAGSLLWDAAMALIGYGIGGSWRSVMKGFSDAGYLLGAAVVVAVAAVIWHRWKTYKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV42</accession>
    <name>A0A7K0JV42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000741">
        <property type="protein sequence ID" value="MST33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="25704" checksum="D6DFA03F501D2933" modified="2021-04-07" version="1">AAVVAAGRDPDRLDAVRRDAERAGGPGTVRTIRADLRDETEVGRLADEAWAQGPVDILVNNAGVGTAEPFLDITADGWREVLATNLTAPFLLAQHAARRMVAAGGGVIVNVASTDAFVAESPFAHYCVSKAGILQLTRCIAWELGHRGVRCNAICPGLTLTPMVEGDLGPAFESAYLPRIPLGRAARPEEQARAILFLASDDASFVNGAALLADGGQLAGFWYDPRFAPPPPDVAAPPAPIPTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV80</accession>
    <name>A0A7K0JV80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000753">
        <property type="protein sequence ID" value="MST33866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="415" mass="44483" checksum="74CD1E2C946D6964" modified="2021-04-07" version="1">MAAEVGAGPSPIGRMTTPEGIADPYPVFDELRAERPVCRDDAYGVWVCTSHAAVQQVLSDPTVSSRRSEAYWDADRLPAEVRATARAVYAALGQRMLMQDPPEHTATRKVMGAAFGKRAVALLRPRIEALVDELLAPYAAGGSIDVVADLAVPLSIRTIAEVLGVPPDDVGRIGAWAEDFATTKDVRPGEPDREAAAVRGVEALLAYLGELVGRRRAGPPRDDVLQLVVDAADATGPREDARLAANLAGLLVGGHDTTTGLVSAGLLSLMRFPGELAVLQDDPGLVVPAIEELLRFESPAQWILRTTTRAMDLEGSEIGPGQLVGLFLGAANRDPAVFAQPARLDVRRRPTQHFAFGRGRHLCVGAPLARLEAELVLSALVTRYRRLEPAGPAPVWRPNFAQRGLARLEIRLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV84</accession>
    <name>A0A7K0JV84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000747">
        <property type="protein sequence ID" value="MST33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7725" checksum="00642424D8C592B3" modified="2021-04-07" version="1" fragment="single">KPVYSQGNTVVTVNMNKGWKWSDGSPVTSADVKFFFELEAAGAKAGKYAPYVPGEMPDDIASVSYPSPYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV94</accession>
    <name>A0A7K0JV94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000735">
        <property type="protein sequence ID" value="MST33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="41"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="36137" checksum="E83A772C28F2C133" modified="2021-04-07" version="1" fragment="single">MDVFTTLRRTVPRRLATRRIGVPPEQGATIVDALVANGTRLRERTAMRHREASGEWTSTTWGQYLLGVRQVAAGLAELGVAPGERVAILGANRPEWHLADLGAMANGCVTVPLYPTSSGEQIAYVCGHAHVVACFVDSHAQLGRLLEIRDQLPALRHLVVAEGARRAADDAVVGLDELRAAGADRLLADPAAVDTRIQQIDPAGVATVVYTSGTTGPPKGTMISHANIMWTLRATTPPYGIGEGDRWLSFLPLSHIAERMMSELAPIGVGGETWFARSLSTLAEDLPACRPTVFLAVPRVWQKLRERVEDALQKQPPAVRAAFARYEALGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV96</accession>
    <name>A0A7K0JV96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000762">
        <property type="protein sequence ID" value="MST33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="358"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="529" mass="55220" checksum="C3F66964026E3704" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC7</accession>
    <name>A0A7K0JVC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycothiol conjugate amidase Mca</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mca</name>
        <name evidence="3" type="ORF">GHK86_14430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000768">
        <property type="protein sequence ID" value="MST33910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="37541" checksum="13EAFC45CE361411" modified="2021-04-07" version="1">MGARGGHRRRRLPPHPPHRVREPLRAGLARRFPYREPVPELSILTVHAHPDDESSKGPATIARYHAEGVRTTLVTCTGGEEGDILNPAMDLPGVKERLPELRREELAEAARVIGYDEVVWLGYRDSGMPESPANADPRCFARAPLEEAVGRLVAAVRAARPQVMVAYGPDQKGYPHPDHLRVHDVAVEAFDAAADPDRYPEAGPAWAPDRLYYVGWSAGRSRAIHEKFLELGRPSPFEGERLERLLQAPERPADAPEPTVVDVHGFTAVRRLGLLAHRTQVDPESPHWFGLPPEIADELYPLDEYELGRSRVTPSGEGGDDLFAGLRDGTAVRADGVGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ0</accession>
    <name>A0A7K0JVJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000787">
        <property type="protein sequence ID" value="MST33953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029539555" evidence="2">
        <location>
            <begin position="35"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="335" mass="35994" checksum="63FB1EB533579865" modified="2021-04-07" version="1">MRHPRRTALVAGAVASAAVLVAGLATGGSGRQGAAVLAASPGHGGHDPAVSVRTTTPIKHLVVIFDENVSFDHYFGTYPDAANPAGEPAFHAAAGTPTVNGLDYALLHDNPNLSNPQRLDRSQALTCDQEHGYNPEQSAFDHGLMDKFVQFTGNQTQDPVAGCTGTPEEGRCGMGPRLPFMVISPYAKRDCVDNQIVDQSSIPRFIEDNWALPRIGNGSTDAITGTIDAMFDFSHPDDRPLSVSPTAWEVLGAGRPHRTWRWAGPTARTGRSARTVATVTDRAVVTLHPEGRWWPERLSPGQQGTPFPGGLLSVDRRGLTWLRPSRGGARTSQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS8</accession>
    <name>A0A7K0JVS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000830">
        <property type="protein sequence ID" value="MST34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="3">
        <location>
            <begin position="3"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="4">
        <location>
            <begin position="743"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="898" mass="99180" checksum="32D0EFE863709674" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW7</accession>
    <name>A0A7K0JVW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional folylpolyglutamate synthase/dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000851">
        <property type="protein sequence ID" value="MST34100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="135"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="283" mass="29631" checksum="B11A03217F11E536" modified="2021-04-07" version="1" fragment="single">MTAGASGAEAWLDGLYDVERTGRMGPPTLERIAALVEALDHPEGAYPVVHVTGTNGKGSTSAMTAALLHAAGRRVGLYTSPHLEHPAERIGLDGRPVTPEQLWTAVGAVAEAAERAGVRPTWFEAMTAAGLWWFRESGVDVAVVEVGMLGRWDATNVVHGQVAVVTNVALDHTEVAGPTRAHIAAEKSGIIEAGATLVLGETDPELRGLFEREQPGRILTRGTELAWSGRRPLGLDGQLVDLRTPWAEHPGVRVGSLGAHQCDNAVLAVGAAEAVLGAALPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX8</accession>
    <name>A0A7K0JVX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aceA</name>
        <name evidence="8" type="ORF">GHK86_15360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000849">
        <property type="protein sequence ID" value="MST34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="392"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="508" mass="56050" checksum="C4E234F52419A528" modified="2021-04-07" version="1">MGAPRGDPRRRHARDRRAGALAARRRRRGGGRRRRRPGDGRRRTRGLRAGRPGRAVRPLPDPARLRPADLDPRKDPPVVTSPFTAAAAELEARWASDPRWSGVERPYSGADVLRLRGSVGVEHTLARLGAERLWELLHSEDYVNALGAMTGGQAVEMVKAGLQAIYLSGWQVAADANLSEQVYPDQSLYAANSVPAVVRRINNALRRADQIEWSEGGYEGGQRRWLVPIVADAEAGFGGPLNVFELMKQMIEAGAAGVHWEDQLSSEKKCGHMGGKVLIPTQQHVRTLQAARLAADVLDVPTLVIARTDALGATLLTSDVDERDQPFVTGERTPEGFYRIRNGMDIAVARALAYAPYADLIWCETSTPDLDEARLFAERVKAEYPDRMLAYNCSPSFNWKKHLDDETIARFQKELGAMGYAFQFVTLAGWHALNESIFELARGYARSGMSAYVELQEKEFALESEGYTATRHQREVGAGYFDQVVTTLAAGSSTLALAGSTEEAQFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW26</accession>
    <name>A0A7K0JW26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANTAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000875">
        <property type="protein sequence ID" value="MST34156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="261"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="34408" checksum="E27BE4E4AA24040C" modified="2021-04-07" version="1">VPDGRILYTNPAACALLRASAAEISRRGRQGFAPPGDPQWKAAVEERARTGRVHFVGPMLRADGSRFVAEVSSSIFTGADGQEHAIVIIRDSTRQIRLQQRSSALQEITGALLAGASSDEVLTMVGHHARLLLDASDAAIFTAGEAPGHVVVAAVDGRAITALAGRDYGPTSLAARTMAQRCSVVVDDLTEAATTSDGRRVGLGPGILAPIVAGTRAFGALMVGAEPGSPPYDGGDLEDVRVFAESAAVALELGEARAAVEAAHRRTAEQLQRALESRIVLEQAKGFIAASRGVGPDEAFARLRGFARRHNASVHETASRVMDRTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD7</accession>
    <name>A0A7K0JWD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000917">
        <property type="protein sequence ID" value="MST34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="19158" checksum="DF635F66B8D0251A" modified="2021-04-07" version="1">MGAIGTGPRPSWVSYLIQRPDGKWVHTTLFSVPAHATVHVKLYQYDSVGALRNPLLATVTGTVGSKVYVTGWVDNKKVNHAPYHVLPADASGHIFDVPAMGINVPLPGYPGSNLCGTPAPCQPSTKYKYDIENFSFHTGAPGVFRWQCFVPCGLSFLDGNGGPMQSIGYMMGFMKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE6</accession>
    <name>A0A7K0JWE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000922">
        <property type="protein sequence ID" value="MST34271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7354" checksum="652781F495F35241" modified="2021-04-07" version="1">MATGTVKWFNSDKGYGFISQESGPDVFVHFSAIEGSGYRNLEENDRVEFEVNQGPKGLQASNVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE8</accession>
    <name>A0A7K0JWE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">coxB</name>
        <name evidence="17" type="ORF">GHK86_14295</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000760">
        <property type="protein sequence ID" value="MST33884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="16">
        <location>
            <begin position="106"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MST33884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="27805" checksum="0AAEC036FAD6065E" modified="2021-04-07" version="1">MIPLHTGVLATYWGSPKGVTTYSKLVHDLWSLNYYIALPIAAIVLGGIVWCVVRYRARPGEDRKPRQFQYHIPIEATYTIIPLILVAVIFGYMYGIENKETRVSKHPGLVIKVQAFQWGWRFTYPNGHQELGSVATEPNINDESALPVLYMPIHETVQIDLSSVDVIHTFYVPEFLYNRDAIPGVKNQVDFNVTTAGQWIGECNQLCGIYHAFMRFKVDAMPKAAFDAWYHAQKPNSLTIAGASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI1</accession>
    <name>A0A7K0JWI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000937">
        <property type="protein sequence ID" value="MST34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="8756" checksum="161A663BA22919CB" modified="2021-04-07" version="1" fragment="single">MNDDQARELTRSLLHTIAPEADLDRLDADEPLRDALDLDSIDFLNFVAAIHERTGVDIPERDYPAVSTLAGCAAYLSGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM2</accession>
    <name>A0A7K0JWM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000791">
        <property type="protein sequence ID" value="MST33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="41"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="231"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="43347" checksum="04102FE10EA0A663" modified="2021-04-07" version="1">MSTGEMEIVPGVAEAEERSVAAAPPYPARVLILSAEMGEGHNAAAAALTTAIADVWPGCEVERFDTLELRGLPFARAASWGYGFQMKSAPVTYEVFYDWLCKFDWFADLSKRAIGSFFGRRLEGFIADRRPDLVISTYPFGSAALQWLRVHRGVHIPTVTYIPALHVHPLWAYAGIDQTYVMYDTAHVHARTEGFEARMRLGAPPVRPSFGTVGKDEARRRLEIDPAAFVVLVTGGAWGLGGIDRAVTALVEAPTPVQILAVCGKNGALAADLRALGQPRDRLAVFDYVDNMHELMAAADVIVTNGAGVTVLEALRTPRPTIAFNPLAGHGKASTAEMIRRDLALQADDVPALVAAVARLATDPELYARMEQAGRAWVEGRDLRESVREMTVLVQGGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT0</accession>
    <name>A0A7K0JWT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000952">
        <property type="protein sequence ID" value="MST34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="243" mass="26058" checksum="73BD8F7FC9A5E0A1" modified="2021-04-07" version="1" fragment="single">RARPAVLYGYGGFDISLSPSWTSAAAAWVAAGGVWAVANLRGGSEEGEAWHRDGMREHKHHVFEDFEAAADRLVADGWTTPGQLAILGGSNGGLLVGAALTRSPERYRAVVCSAPLLDMVRYERFGLGATWNDEYGTAADPEELGWLLSYSPYHHVEDGVAYPAVLFTIFDNDTRVDPLHARKMAAALQAATSGSPEDRPVLVRREGEVGHGARSQRRRAVLDADELAFLAACTGLALPAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV6</accession>
    <name>A0A7K0JWV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_17080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001002">
        <property type="protein sequence ID" value="MST34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="36334" checksum="2D1B1807FB8E3B43" modified="2021-04-07" version="1">SEFGAGTMPDWAWTLLIVAALTLLAYLGVQVSTRFQLAMALISLTVLTIFFIYVIVKLGGANSARAFNPSSAADGWSGIFLGVLYGVLLFVGFETSANLAEETPNPRREIPFAVMFTAALALGYFVLATYVEIAGFHFDMKQIVAAAGGPVFALGSPASAGGYGAVWLRRVLELVVLFDMLAVLMGIFVSASRGIFGMARDRRLPAPLARVDPGRGTPVVAIGALSALCVVFVLLDQFFPGLWALPKTPHYFAMFAWGSTFGAFSMVIVYLLMCVGALRRPQGGGALLPVASVVGILITAGALFGSVYKVTAPTIWAPWISLIWLGIGIVVTTLTLGRRPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX0</accession>
    <name>A0A7K0JWX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000824">
        <property type="protein sequence ID" value="MST34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10308" checksum="B256D9C83397C0D5" modified="2021-04-07" version="1">GRGRTVQEVLEILPADVGTSLAVEESVPAAFGVLAAVPDDPWLACRVAASLGGDTDTIAAMVGAVAGAALGVDALPAHARETVAAVNGLDLGPLAEGLLALRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX6</accession>
    <name>A0A7K0JWX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malto-oligosyltrehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">treY</name>
        <name evidence="3" type="ORF">GHK86_17130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001004">
        <property type="protein sequence ID" value="MST34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="20"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="813" mass="88910" checksum="63E597345D8FB00B" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX12</accession>
    <name>A0A7K0JX12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001026">
        <property type="protein sequence ID" value="MST34476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_4" evidence="2">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="197" mass="20336" checksum="1CDDF28FD80DC768" modified="2021-04-07" version="1">TGQSVGPAVLLYGAASALYSPSSWPTLGQALQSLQQGDGAPILSMFDTYVGRNRNGTFANTDEAETAIDCATSPAPTLGQIRAAAPAAERASPVFGLLDLYSLASCAVWPVRASGPSGRVRAPGSPAIVVVGSTHDPVTPYAWARGLAAELPHGVLLTRDGGGHTAYFQSRCIELAVDRYLTTTVPPRPGTTCPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX27</accession>
    <name>A0A7K0JX27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001004">
        <property type="protein sequence ID" value="MST34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="9681" checksum="43A91693B2D0D5E0" modified="2021-04-07" version="1" fragment="single">MTPPSAATRKALAADSRVALLEALTAVGRPLDAAEAGRLVGLHRNTARVHLEQLADAGLVERRGEDRSRPGRPRVLYATTTEVAAERAAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX34</accession>
    <name>A0A7K0JX34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <ecNumber evidence="12">1.17.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_17505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="12"/>
    <dbReference type="EMBL" id="WJHE01001047">
        <property type="protein sequence ID" value="MST34510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="22101" checksum="3DD3875A1570FD1D" modified="2021-04-07" version="1">RRAITIGADTGALIDAGAEVVVDFTVRDAAVRNLPAYADAGLHAVVGTTGLGADDLAAAADAYPADGPLGCVVAANFAIGAVLLMRFAELAAPWFETAEIIELHHDAKADAPSGTALATAQRMAEASGKWAPDPTRTETVPGARGALGPGGIRLHAVRLRGLVAHQEVLLGTEGQTLTLRHDSLDRVSFMPGVLLAVRSVPARPGLTVGLDPLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX40</accession>
    <name>A0A7K0JX40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001044">
        <property type="protein sequence ID" value="MST34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3_4" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="10836" checksum="F99617C155EFD0F9" modified="2021-04-07" version="1" fragment="single">TTAPPADPSVGSADVVVEAADLCPRFTATVLTGVRVGPSPAWLAQRLTRAGMRPINVVVDVSNYVMLDVGQPNHAYDRDRLGGGGLLVRRARDGERLVTLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX45</accession>
    <name>A0A7K0JX45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001051">
        <property type="protein sequence ID" value="MST34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="23929" checksum="56A4F7509A3C3E6D" modified="2021-04-07" version="1" fragment="single">MASDRSVPPVVAVVVTCQPGPWLEETLRAVGGQDYPNLSVLVVDGDSGDGDDAHGADLAERVAAVLPDAYLRRRDRPGGFAAGANEVIGAVDGASYFLLCHDDAAPAPDAVRLLVEEAFRANAGIVAPKLADWQDPDRLLAVGATIDRVGTIQPVVERGELDQGQHDTARDVFLAPGGATLVRSDLFEALGGYDPELPAGGEDLDLCWRALIAGARVRVAPAARVRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX53</accession>
    <name>A0A7K0JX53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenylalanine--tRNA ligase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_17610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001055">
        <property type="protein sequence ID" value="MST34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="19006" checksum="74BF2DA89A6310AB" modified="2021-04-07" version="1" fragment="single">MLAPLSWLRDYAPFDRPVGELAAALSDLGLVVEGVERVGQGLDGVVVARILDIRPHPNADKIRLVDVDAGDGEPLQIACGAWNMQVGDLVPLARIGAVLPGGMEIARRKMRGEWSNGMLCSPEEVGLAAVPGVDGLLILGPGSAAPGQPMVDALGGEDVVFDLDVSPNRPDALCMAGVARDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX66</accession>
    <name>A0A7K0JX66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_17695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001064">
        <property type="protein sequence ID" value="MST34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="100"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="26854" checksum="7AD43B7E2199BCCE" modified="2021-04-07" version="1">MSAAVHTRPDEYAQHGSPFWLPLASRDWQVGAQRRPHRGTATWLGRGVRLLRRLQEPLVRHRGSPDREADPRQGSGQDEGRGHATTARDRRRRAHRRGVADRQAFLEHWLTTVVAGRVGERTRDSYERIVRKHLSPALGHIRLEKLTPEDVDRMLAAKAATGLCRAYITRMRIVLADALEHAQRRGLVVRNAGALAVMPRTAAPTPRRPSTSRSCSGTSSGPRRAAGELVARQRHGTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX73</accession>
    <name>A0A7K0JX73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7284" checksum="27E23795790B1DBC" modified="2021-04-07" version="1" fragment="single">MATVLVVDDERDICELVRINLELDGHRVAVAHDGDAALTELERVRPDLLILDVMMPGRDGFSVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX86</accession>
    <name>A0A7K0JX86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001073">
        <property type="protein sequence ID" value="MST34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="32959" checksum="8BD4A2D08C3951F1" modified="2021-04-07" version="1">PDADPDATSRGLSPVVLPRPVSSAPPASADTPPPAGKRRSRALRTAAALTVVFALGAAASGGALFGYYQHELNGNTRRVNALVDGYKRQFARAEADLRSVAAAGRAQIQSAATADRQGGTAPSTQQALVRSLAPSLFVVMTSSTAGQPSVGTAFVVASSATESLLLTSYTTVQAATTIPGPRVEVRPARGSGRARPVTVRTWDPTHDLAVLVLPVGNLPVVRLAPAHPGPQLGQPVFAVSALGATGGAIAAGEVDDVSSSGIADDIPIGAAYQGAPIVDSRGDVVAVASRSYAPLGVAPGGIWYAPFVGMACDEVLNCPGGSLSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA8</accession>
    <name>A0A7K0JXA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000889">
        <property type="protein sequence ID" value="MST34184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="32070" checksum="A9DCD15740A2FB55" modified="2021-04-07" version="1">MSRRSEIVTNGPVTVETYLDGRRSPVRGQDVLVLPSYGRDGGEDFDPLAAALAAAGHSVFRPQPRGIAGSSGPMEAVTMEDLADDVAAVIDQLGHAPAVVVGHAFGNWVARVLATNHPDKVGAVILAAASGRTVDPEVNAAPFRAGDLSLPDHERLAALRLAFFAPGHDPSVWLSGWHPTTLTMQHEAVKRLHPAPYRDAGNAPILEIIAEYDPFHTRGEWGDLRAALGDRVTTTVIADAGHTLFPEQPDTVAETIIGYLSCMPERDHVGAEQRRPRRSSRSVRPGSLVAGPPGATGSIVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY86</accession>
    <name>A0A7K0JY86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001033">
        <property type="protein sequence ID" value="MST34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="230" mass="23443" checksum="8635B3451F95D559" modified="2021-04-07" version="1" fragment="single">MTSTSLTPAHRPPGPDLRHGPDASGGPGPGGPPPGDEGPRRHRGRTVLVVEVVVLALVVGFAAEEAPGLASEIARDLARLRHPSASGLTLAVSAEVVSLLAISQVPRWLLRRGGVRLGPVDAVALTLAANGMAIILPAGAVSSTVWTAHQYSRRGARAALATWTVLASGFASAVTLLAVAIVGALAAHVARPSLLLGGSVVFVGATAGIVALTHRAEGLRRPDHPPLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB2</accession>
    <name>A0A7K0JYB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001322">
        <property type="protein sequence ID" value="MST34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="62"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="167" mass="17823" checksum="E4BC10BC849F64C1" modified="2021-04-07" version="1" fragment="single">MEALARGLDVLVAFDAGHRTMTLSEVAGAAGLPRPTARRLLLTLEQLGYVRSDGGAFALTPKVLALGMSYVSSLGMWDIARPHLERLVARTGESSSMTQLDGSDIVYVARVAVPKIIALRVEIGTRFPAVQTSQGKVLLAALGPEELDRTLAQPSRSGLPPYIGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM9</accession>
    <name>A0A7K0JYM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001125">
        <property type="protein sequence ID" value="MST34649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="47" mass="4676" checksum="F5C71037FE796AD9" modified="2021-04-07" version="1" fragment="single">MTPFAEPRTDGPLARSALVVNIMGLGMLTAGVAVQLPPAGSRQAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV4</accession>
    <name>A0A7K0JYV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_18595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001177">
        <property type="protein sequence ID" value="MST34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="15330" checksum="5D91E2C7F04A1923" modified="2021-04-07" version="1">MVATLVRSIFEQPDAEATWAQLETVIDKLNSTGFADASAFVLDAAEDILAFSAFPVEHWPKIRSNNPQERLNKEIRRRTDVVGIFPNRAAVVRLVGAILAEQNDEWAITKRYMRPESLKTVNTTALAAGPPDADQLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW4</accession>
    <name>A0A7K0JYW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001180">
        <property type="protein sequence ID" value="MST34734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029488047" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="47" mass="4698" checksum="F28240B7B8F15F61" modified="2021-04-07" version="1">MAVVAVVAVVAVGRRATVTRTVVPAAPVTTSTPPPASVARDRMPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY1</accession>
    <name>A0A7K0JYY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001485">
        <property type="protein sequence ID" value="MST35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="31"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="24948" checksum="D9AD0E4E3E28A004" modified="2021-04-07" version="1" fragment="single">AGDPVLQTVAAAVLPSAFVVGPGLHPTRNAALVTAATEVSSSPQVVDYRINPDAAWSDGTPVTAADFVYTWEADSGQRRFRDTGGHLFTPASTAGYDRVASVAQGAAGPGSVVVRFATPDPDWRALFSPLLPAHVGRRVGFDTGFTNPVTDLVSAGPFVVQSWRPGVDVVLARNPAWWGQGSALSTVTVDEVPNAGIGGVSLQQGQLDAAQLPFTPGGAKTLRATPGLSVWTGGSGVYDDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ37</accession>
    <name>A0A7K0JZ37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001535">
        <property type="protein sequence ID" value="MST35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8227" checksum="F0A7A247041B7F95" modified="2021-04-07" version="1" fragment="single">MLTDADRVPLAARAWIADGVRGALVAADGTIDWYCPDGFGGAPALFHLLDPAGAAIRVGPVRQGTGSARRLPPGGQRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ50</accession>
    <name>A0A7K0JZ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001532">
        <property type="protein sequence ID" value="MST35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7222" checksum="E1378B6C3BF73E83" modified="2021-04-07" version="1" fragment="single">MSRRTSFSDHAGRLALAWVFLRAGSDVLRDPGRAARTAGPLLGRLRRRAPVALPDDAVLVRANAATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K008</accession>
    <name>A0A7K0K008_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001470">
        <property type="protein sequence ID" value="MST35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="14501" checksum="CD45463043ECE8A0" modified="2021-04-07" version="1" fragment="single">MRRRGVGRPVRVERCFAFVDLCGFTAFADRRGDDAAVAVLTALRTALREIAARRGVRVVKWLGDGAMLSGTDTSHVVALVVEITAQAGAGTIPLPLRAGLAEGPVIMFEGDDYVGRPANVASRLCGAAEPGQVLATPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0T4</accession>
    <name>A0A7K0K0T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001692">
        <property type="protein sequence ID" value="MST35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="12223" checksum="7437792898A39D50" modified="2021-04-07" version="1" fragment="single">AADAVVEGVHADLSLLGLDDLGWRAVVANLSDVAAMGGTPGHCVVTVAGPPDLDLDALYDGIAAAATTYGCPVVGGDLVDAPVAVVTVAITGWVDGPPVLRSGARPGDALWVTGPLGASAAGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV5</accession>
    <name>A0A7K0JMV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">aroC</name>
        <name evidence="11" type="ORF">GHK86_00350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="385" mass="40944" checksum="7A0C89E0315DF44E" modified="2021-04-07" version="1">MLRFLTAGESHGQALVVVVEGLPAGMAITEEQIGSELARRRLGYGRGPRMRFEQDRLTLVGGIRHGVTLGSPVAIEIANTEWPKWEQEMSPAPGRTEKPLTKPRPGHADLVGMQKYGFDDARNILERASARETAARVAAGALAKVLLAELGVAIVSHVVAMGPVTTKGDRRPGPADLEAVDASEVRCFDPEVEAAMIAEIKAAAKVGDSLGGVVEVIGYGVPVGLGSHVHWDRKLDGLLGQAMLSIQAVKGVELGDGFDVAHRRGSEAHDPITWDPATGYGRESNWSGGLEGGMTTGEPLVARVAMKPLSTLNRPVLKTVDTVTKEETVSFKERTDVTAVPAMGVVAETMMALVLAGEALRKFGGDTVAELRRNHDAYVQSLDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN59</accession>
    <name>A0A7K0JN59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase HrpA</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hrpA</name>
        <name evidence="4" type="ORF">GHK86_01510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000061">
        <property type="protein sequence ID" value="MST31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="81"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="279"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="840" mass="93940" checksum="861D9BC186D15294" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN94</accession>
    <name>A0A7K0JN94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000068">
        <property type="protein sequence ID" value="MST31442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="23863" checksum="2AF70B4629E1F775" modified="2021-04-07" version="1">ALALAAAGVDVVITYRTQDTLAKQAVDEVRASGRRAAALQLDTTDLDSFPAFADALRAELPAGTLDILVNNAGSALYSPLATTSRADFDRVFTEHVAGPFFLTQTLLPLLADGARIINVSSALTRVSFPASGPYAAAKSALETLTRYQALEFAERQITANVVAAGAVPTDFGDAHLRSDPALQATMIGFTALKRLATPDDIGQLIAGLTTASGTWVTGQRIEASGGMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF6</accession>
    <name>A0A7K0JNF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000078">
        <property type="protein sequence ID" value="MST31485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="5867" checksum="9905B856A3FDC98F" modified="2021-04-07" version="1" fragment="single">MSRSARLWAVLVANLALVGALIGVGLAAHSLGVWAEGADYLADAAAIGVALAALRLQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM6</accession>
    <name>A0A7K0JNM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">GHK86_02265</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="129"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MST31555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="27595" checksum="BE293C3CD30103E0" modified="2021-04-07" version="1">MRIDILTMFPELVAPWLDASLIGKARRGGRLDLRVHDLRAGADDPHRSLDDAPFGGGAGMVLAPEPVFRAVEQAAPARPLLLLSPSGRPFTQRWAEDLAAGGSLGLLCARYEGVDQRIADHLVDGEVSLGDFVLAGGEVAALAVVEAVCRLVPGVMGNEASAREESFAEGLLEYPHYTRPAEFRGWAVPEVLRSGDHGRVDRWRRAQALVRTARRRPDLLAARGGLSDADRALLAEFGMLGELDGTGPVVAPGEDPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN6</accession>
    <name>A0A7K0JNN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000097">
        <property type="protein sequence ID" value="MST31565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="30" mass="3031" checksum="4D3E0FC89E4F5E48" modified="2021-04-07" version="1" fragment="single">MLEGGRRVTVLTGAGISTDSGIPDFRGPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP4</accession>
    <name>A0A7K0JNP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA ATPase forming ring-shaped complexes</fullName>
            <shortName evidence="2">ARC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">arc</name>
        <name evidence="5" type="ORF">GHK86_00465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer. Assembles into a hexameric ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000018">
        <property type="protein sequence ID" value="MST31204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="241"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="252"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="564" mass="62914" checksum="0BA9A64F43A4047E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX1</accession>
    <name>A0A7K0JNX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000106">
        <property type="protein sequence ID" value="MST31613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="132"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="573" mass="61654" checksum="8D2407182A72AB97" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP23</accession>
    <name>A0A7K0JP23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000118">
        <property type="protein sequence ID" value="MST31695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="4">
        <location>
            <begin position="364"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="700" mass="75319" checksum="FD0A0570B6BECE35" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP45</accession>
    <name>A0A7K0JP45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">codA</name>
        <name evidence="2" type="ORF">GHK86_02765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="42"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="446" mass="48963" checksum="9B29416DB6F8BB64" modified="2021-04-07" version="1">MLVQRARRLAQPTAPPVSVWVDQGRVVAIDEDAVGDSAAAKDVLDADGSLIAPPYVEPHVHLDTALTAGEPHWNASGTLWEGIARWSERRETLTRDDVIRRAEEVIRWQVANGVLHVRSHVDITAPDLVGLDAMLEVRDRVRDLVRLQLVAFPQEGICSSPGGEHRLEEAVRRGVDVVGAIPHFEDTREDGVRSVELAVRLAEREGLPVDAHCDEIDDEQSRFVEVLATLALRTGLRERVTASHTTAMGSYNPAYAYKLERTLRRSGINLVCNPMVNLHLQGRLDDYPKRRGLTRVKEMLAAGVNVAFGHDDILDPWFPLGTANPVMVAHVGALATQLMGPAEIAECYRMVTDRAAEVLGLGDRYGVEVGRPASFVILPAADPFDIVRRQVRPSHVVAHGRVVARTPATVTDLHWPGRAPETVDFVRRGKLSVPGGAGRARRSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE9</accession>
    <name>A0A7K0JPE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000150">
        <property type="protein sequence ID" value="MST31828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029874795" evidence="1">
        <location>
            <begin position="36"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="418" mass="43143" checksum="63F8F37E834E2946" modified="2021-04-07" version="1">MAGVHRRTRRAQRVLAVLGVLLAGGGLAGCGPSRATQPSASVPTPEKLARCTHTTAIAPRLSPPRPMATVPGPPGFPSTPVGVVADRGWAFVTEMAGYRPDTGLVSVLRLTPGTGRVARTVAVPGVPFGAALADRNLLLIANYAGGLDLLDVRRLETGQLTPLVGTLRSPGSGDAEVAVDGAYAFVSEENSADVAVYRLSAPGPDLSGRLRRPGRLVGEVPVGPRPVGLAVDRQDHTLYVVSQAGGPSGQGVLTAVGLGLAEHHPAAAAEGTVPAGCDPVRVALSAHGALAWVTDRGANAVLAFRLDPRRRSPGTLVAAARVGPAPVGITVVDHGAVLLVADSNRFAQPERRQTLAALDAADLLARRPSLIGYLPAGAFPRQFSTDPTGDVLFTNFDSLTVGILSPTDLSWLRHQRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT9</accession>
    <name>A0A7K0JPT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="26946" checksum="22A7919163EBFDE9" modified="2021-04-07" version="1">MSPRPYNLGRRQDQIAHSRRQILDAARALLGDTSGYAAFTVEAVARRADVARATVYYQFHSKTGLLEAVCDDLADLGGLQRLSAAFSAPEPADAIGHFVTAFGHFWAADRPAMRRLRALAALDPDVHQVVAQRDQRRRDGLAVLTDRLRPDLQPSRRNRTINVLATLTSFETFDSLAGPDRPLTAATTDIIVLAIAAIAAIAAIPVAPSRPDESNTRAPAARSKNHSITPTRTAARNNRRNDPSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ39</accession>
    <name>A0A7K0JQ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000200">
        <property type="protein sequence ID" value="MST32033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="9083" checksum="4E1E977A22BE6718" modified="2021-04-07" version="1">MGEVETWIDLTAVALPLVSFRTSFVFHADGAVLTSDSTLRFRDRAELTASLTSAGFVIDEVREAPDRPGREMVFVTTAGQRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ45</accession>
    <name>A0A7K0JQ45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000116">
        <property type="protein sequence ID" value="MST31684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="95"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="16516" checksum="566F87BC6ABD4923" modified="2021-04-07" version="1">IAAGLALTGGGHAARVAGGSSPSTSPATTPTSNGGTSGSGATASPSTTTPSSGSSGAGTAPTTTNGSSTTTGSTSTTTSTTTTSTTTGPPAAGAPVLASVTPAAGKAGETVTLTGRNLYSSNGQISVVVGSSAAGVTCPSETRCVVTLPALRTHGQVPLRMTTSGGRSNTVMVTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC7</accession>
    <name>A0A7K0JQC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000223">
        <property type="protein sequence ID" value="MST32146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="6945" checksum="D73BDB72DC38771B" modified="2021-04-07" version="1">MQATTSKPAPSTANGSYELPLLHARLPARAVEAGFWGSLAGATLLGAIDPPLALLVGAGVLVARHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR5</accession>
    <name>A0A7K0JQR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_05975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000261">
        <property type="protein sequence ID" value="MST32271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="12">
        <location>
            <begin position="289"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="802"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="954" mass="105335" checksum="56759F3977D11D53" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS4</accession>
    <name>A0A7K0JQS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS30 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_06060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase IS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001598">
        <property type="entry name" value="Transposase_IS30_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01043">
        <property type="entry name" value="TRANSPOSASE_IS30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="207"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="389" mass="43478" checksum="B4286F2CE580061C" modified="2021-04-07" version="1">MCPVSLAPPSGRYLSLAEREEIAIARAEGCGVRETARRLGRSPSTISRELRRNAATRTDSSGYRATTAQWHAERRARRPKIAKLAANDQLRAYVEDRLAGLISRPDGTPVAGPTVRFKGRRHGPRQDRRWAKAWSPEQISARLRVDFPADETMRISHEAIYQSLFIQGRGALRRELVACLRTGRALRVPRARVKGRGKHFLTPEVMISERPAEVADRAVPGHWEGDLIIGLNKSAIGTLVERTTRYTMLLHLPPMEGHGRAPRERNGPPLAGHGAAAVRDAIAETFAALPEQLRRSLTWDQGTEMADHARLRIDTGLAVYFCNPHSPWQRGTNENTNGLLRQYFPKGTDLARHRRDDLDAVALALNNRPRKTLGWTTPAEVLDELLQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT2</accession>
    <name>A0A7K0JQT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_04255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000178">
        <property type="protein sequence ID" value="MST31939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="10"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="FAO_M" evidence="5">
        <location>
            <begin position="374"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="430"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="4">
        <location>
            <begin position="755"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="838" mass="90566" checksum="AC46EE3957B68A51" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU6</accession>
    <name>A0A7K0JQU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polynucleotide kinase-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024028">
        <property type="entry name" value="PNKP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16536">
        <property type="entry name" value="PNKP-ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16542">
        <property type="entry name" value="PNKP_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04075">
        <property type="entry name" value="bacter_Pnkp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="182"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP_ligase" evidence="3">
        <location>
            <begin position="468"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="2">
        <location>
            <begin position="791"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="850" mass="92219" checksum="E88B03F0FC0CC4AC" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX0</accession>
    <name>A0A7K0JQX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000190">
        <property type="protein sequence ID" value="MST31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="321"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="422" mass="44946" checksum="1999A3A4D5D0982B" modified="2021-04-07" version="1">MSTSGAVVVIGQGYVGLPLAMRAVEAGYDVIGLDADAGRVKRLGSGQSYVEDISDEEVAAAVATGRYRATTDYADCAGFSVAVVTVPTPLREGTPDLSHIEESVRALAPQLTAGATVVLESTTYPGTTEELVGPLLEEGSGLAVGRDFHLGYSPERIDPGNPTWRFANTPKVVSGVDAASLEAVAGFYASVVERVVPVSSPAVAETTKLLENTFRHVNIALVNELAMFASDLGIDVWEAIEAASSKPFGFMPFRPGPGVGGHCLPIDPSYLSWRVKRRLGQSFRFVELANDVNEHMPDYVARRLTAAFNRQRRAVNGSRVLVLGLAYKPNTGDARESPATVVVERLLGLGAEVLAADPHVEESHVDARVQRVDDPVAAAADVDAVVLVVDHADFPLEDIAAAARYVLDTRHRLAPAPHVEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX3</accession>
    <name>A0A7K0JQX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21651" checksum="843D95DB6B36FFD5" modified="2021-04-07" version="1">MNIALIGATGQVGSRVLAELLLRNHTVTAIVRRPEEVPVRPGITARRGDAANEKDLSSLLAGHDAIVSSLRFSQVDPHKLLGAVRASGVSRYVVVGGAGSLEVSPGVKLIDTERIPQQVRPEAAAGVVFLDLLREEAELDWTFVSPSVTFAPGERTGSFRIGDDALLTGPEGSRISFEDFALALVDELETTAHPRRRFTVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR00</accession>
    <name>A0A7K0JR00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">GHK86_04720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000199">
        <property type="protein sequence ID" value="MST32029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="139"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="243" mass="25901" checksum="67240C0B2788419A" modified="2021-04-07" version="1">MGDTSKPWSRVVLKLSGEAFASPAADETIDGGVVDRIAKEIAEVCHDLGVEMAVVVGGGNIWRGATGSASGMDRASADYMGMLATVINALALRDALERQGQPTRVQTAIGMSELAEPYIRLRAIRHLEKGRVVVFAAGTGNPFFTTDTAGALRAVEIEADVLLKGTHGNTDGVYDADPATHPEATKLDEVSFDEVIAKDLRAMDLTAITLCKENGMPILYFSIMEPGNLRRALSGERIGTLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR19</accession>
    <name>A0A7K0JR19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_06430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="1 3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="6">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="5">
        <location>
            <begin position="184"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="291"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="554" mass="60049" checksum="1397E855AC1D1750" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC9</accession>
    <name>A0A7K0JRC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000302">
        <property type="protein sequence ID" value="MST32463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="16090" checksum="9D6F4DDA64F137F7" modified="2021-04-07" version="1">MPVRDARPGDVAEIAAMVREHADHEGALEQCRFDAGAGRAALFGPSPALRALVAHPEGEAERPAGFALWYPTFSTWAATAGIWLEDLYVRPEHRRSGLGRELLAALRATTPGRIEWDVKHGNDDAAAFYRRLGAAPVEGWTKYRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT3</accession>
    <name>A0A7K0JRT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TraM recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000352">
        <property type="protein sequence ID" value="MST32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TraG-D_C" evidence="1">
        <location>
            <begin position="230"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="392" mass="41109" checksum="6E5C0A9C2D0774B6" modified="2021-04-07" version="1">TTSTRPDNLALTLAERSGRGPVMVFDPEGLAGPLPAGMTQLRWPLWRGCEAPGVAIARAEILVGDGSGSGVENSNFWRNQAVAVTRCLLHAAALAGAGPDVLYRWSHTAGHARAALEVLGGHPGASAGWDSALDAVISHDPRTRDSIWSMVANAFALLADPQVRTTLDPAAGKALDPTALIALGGTVYLLGTASGAGRSTSRLVAALVEDLVGAARHLAARSPGQRLDPPLTMVLDEAANYPLECLPGLMAEGGGSGIATVTVLQSLAQARDRWGREAAQAIWDAAIVKVVLGGSANAEDLADLSRMLGERAEQEWSRTLHPHQPGASLSSSTRWRPVVEVAQLRALPFGQALLILRAAPPILLRLSPWTARRDHHRLEAGRAAWEQAAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU4</accession>
    <name>A0A7K0JRU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000354">
        <property type="protein sequence ID" value="MST32666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="318" mass="33662" checksum="DDC8AF23580A6FAA" modified="2021-04-07" version="1">MLLLAVGLSVLFSSPDKPAVTLRQWADAQPTGFVATAASELEGTSTTATYGQPFNTTPGAAQKLGPISIQKWFGVVYPIDPARSFVLDPLSTLPSTPALRTAIHRYEAAGPAQQHAWAAAYAKLLASRSLSAGLPPVTTSAEGPVPTLLSSLLGMARSGGLDSALVAHSSFYNDDYTKPLMFLGDSATAQDNSYWNKIVTAEHLQGSQWGVMNETGSWPGQPWLWLYSMWYQVPPMSTSGNADILVIAIVAVLSVALLLVPFIPGLRSIPRWIPLHRAIWRRYYNEAPVAATDPAAGTAAPPAPGKDLPAGALGTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ4</accession>
    <name>A0A7K0JRZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">GHK86_06360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="262"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="412"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="502" mass="55106" checksum="2D478A33925337E0" modified="2021-04-07" version="1">MPGTHVLAVDQGTTGSTALVLDPDARIVGRGYAEIPQHYPRPGWVEHDPADLWEVSRRVAEAALADAGIRPGDLAALGITNQRETVVLWDRRSGEPVANAVVWQDRRTARRCEDLRSRGLERFVRDRTGLVIDAYFSGTKVAWLLDHVDGLRRRAERGELCFGTVDSWLLHRLTGGRVHATDVTNASRTMLFNIDTLEWDEELLAELDVPREVLPEVHPSLHEFAETAPGAFLGASVPVAGILGDQQAALFAQACFASGQTKNTYGTGSFVLSHTGGQRHFDQTAMLSTIAASVEGEPTQYALEGAVFATGSAVQWLRDELGIIRHASETEALARSVEDTGDVWFVPALTGLGAPHWDPYARGTVLGLTRGTSRAHLARAVLESIAYLTRDVVEAMQRQSGIRIGELRADGGASANGWLMQFQADMLGIPVDVPEQIETTSLGSAFAAGLRTGVWKDRAELARIRRTAHRYEPSLDQDRREARYRRWKQAVERSLAWAAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS64</accession>
    <name>A0A7K0JS64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ORF">GHK86_08540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000383">
        <property type="protein sequence ID" value="MST32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="35029" checksum="DDACA4D632002EE4" modified="2021-04-07" version="1">MTVNDGVRDVVIVGSGPAGLTAAIYTARATLAPLVIEGEPSSTSDQPGGQLMLTTEVENFPGFVDGIMGPELMATMRAQAARFGAEFLTTRATRVDLSERPFRVWAPDPATGAEVEHRARAVIVSTGARSLMLGVDGERELLGYGVSTCATCDGFFFRGHQIAVVGGGDSALEEAMFLTKFADTVTIVHRRSELRASKIMQERAFANPKIRFVWDSVVSGVVGDTKLERVRLHNLVTDEDSELEVTGLFVAIGHAPNSDLFKGQLDLDDAGYIKTLADSSFTTVPGVFACGDVQDHVYRQAITAAGSGCMAAIDAERWLEAEAHQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS70</accession>
    <name>A0A7K0JS70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rplL</name>
        <name evidence="8" type="ORF">GHK86_08605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000386">
        <property type="protein sequence ID" value="MST32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="6">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="13243" checksum="ACAB83AB30EE9496" modified="2021-04-07" version="1">MATKEEILDSIANLTVLELSELLKEFEERFGVTAAAPAVVAAPAAGAGGGAAEGPAAEEKDEFTVVLASAGDKKIQVIKEVRALTSLGLKEAKDLVDSAPKPVLENVSKDDAEKAKAQLEGAGATVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF5</accession>
    <name>A0A7K0JSF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M24 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_09085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000415">
        <property type="protein sequence ID" value="MST32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="9577" checksum="A947C4C3E16BF758" modified="2021-04-07" version="1">IFAWWAERITGGGADAHERLTGFVHGTGHGVGLDVHEAPSVAATSTDTLKSGHVVTVEPGVYLPGQGGVRIEDTVVVTDDGCTPFTLTPKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL4</accession>
    <name>A0A7K0JSL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000435">
        <property type="protein sequence ID" value="MST32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15681" checksum="7D230676BDFCB1A7" modified="2021-04-07" version="1">ASDAVLRHRPGPGANTVSWLVWHLTRVQDAQLADALGHPDTWQTEGWEERFGLPFEPGATGYGQDPDEAARVTAGRELLAGYHEAVAHHVHEWLAGLGDADLDEVVDPGWDPPVTLGVRLVSVLADALQHVGQAAYVRGLAERAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST9</accession>
    <name>A0A7K0JST9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="3">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="12132" checksum="CA733A4B7849C76D" modified="2021-04-07" version="1">RRVPDVLARHVGPLVDELCRRNGRTASGVAAWAVHPGGPRVVDVVADRLGLSDEQVHESRLVLAERGNCSSATILLVLEEIRRHRDLRPGDAVVALAFGPGLTLYAALLEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV2</accession>
    <name>A0A7K0JSV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000459">
        <property type="protein sequence ID" value="MST33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="354"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="526"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="686" mass="72169" checksum="918E9F3B78F65A62" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW1</accession>
    <name>A0A7K0JSW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000463">
        <property type="protein sequence ID" value="MST33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029650474" evidence="1">
        <location>
            <begin position="31"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="26816" checksum="61D953EC78691701" modified="2021-04-07" version="1">MTLGRRRMLMGVASLVTVGAMALAPGSAIAAGHGGRKGGGGGETTVANNLSVPAVFVDNPGFGLTTADLQVPTGEPSSGYQVPGEYFVQGINHWQAEFEVVPAGVATATAAWGDNLTGSASLAAGHPIRVEMALTDDQVVLPGYTVVKLDTTVADRLAPYGTKAIPGPDGTYTAETTDMPARVWVAGATLSVTDPAGATTTFPMPGEINATGAVVFGYNWRPSEPGGYTLAFHVPAGSVNITNSTTLAVTVKSGSGGGRGGGGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY5</accession>
    <name>A0A7K0JSY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="5" type="ORF">GHK86_10025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000469">
        <property type="protein sequence ID" value="MST33055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="10667" checksum="B688823F2AA58925" modified="2021-04-07" version="1">MARRTKETGRVTPKGGRPARTSAATATTTVSGRYTPPIPDEYRSSPWWVPALVLAFMGLGVLAIVLNYLSLLPASPTNWYLLGGLVGVIAGFIVATRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB3</accession>
    <name>A0A7K0JTB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000508">
        <property type="protein sequence ID" value="MST33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="28110" checksum="15ABFBBAB56484B1" modified="2021-04-07" version="1">MSHLLRRHAPISEAAWAQIDAEAVARLRPQLAARRLVDFDGPKGWAASAIDLGRVETLGDPPSPGVEAQRRRVLPLVELRVPFTLERAALDDAERGDPAIDLGPLAGAARQLALAENAAVFHGYAAAGIRGITEESSHSLVAVHGEWTAYRNAVASAVARLRGSGVSGPYGLALGDEAWLGVSETIEAGYPLLEHLTRIVGGPVVWAPGLSGGLLVSQRGGDFVLHVGADVGVGYREHDERTVTLYLEESFTFRVLEPDAAIALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK8</accession>
    <name>A0A7K0JTK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protocatechuate 3,4-dioxygenase subunit beta</fullName>
            <ecNumber evidence="6">1.13.11.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pcaH</name>
        <name evidence="6" type="ORF">GHK86_11120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.3" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000538">
        <property type="protein sequence ID" value="MST33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024756">
        <property type="entry name" value="PCDO_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012785">
        <property type="entry name" value="Protocat_dOase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12391">
        <property type="entry name" value="PCDO_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02422">
        <property type="entry name" value="protocat_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="5">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="24705" checksum="EAC878ACD9FE89F9" modified="2021-04-07" version="1">MNLDPPYDFPPYRSTALRHPTRPLVPMAPGPIETSGPLLGGGRVRPGDHDLTRQGGGEPLGERINVSGRILDADGRPVRGQLVEMWQANAAGRYHHRVDQHPAPIDPNFAGAGRCLTDDEGRYRFVTVMPGPYPWGNHPNAWRPAHLHFSVFGTAFAERLVTQMYFPGDPLQAHDPIFHGVRDPKARERMIAAFDWATTEDSFALGYHFDLVVSGRLATPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL0</accession>
    <name>A0A7K0JTL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD synthase</fullName>
            <ecNumber evidence="4">2.7.7.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_11175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RibF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000543">
        <property type="protein sequence ID" value="MST33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD_syn" evidence="11">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="18297" checksum="26C2D1DE625B9DFA" modified="2021-04-07" version="1" fragment="single">APVAAPGVLARGAAVSIGAYDGVHLGHRALIGRTRQEASRLGCASAVVTFDRHPATVVRPASAPRLLTDLDQKLALLASTGVDVTVVVHFDERRAAEEPAHFVREVLVDLLHARAVVVGEDFHFGRARAGNVELLRTLGAELGFSVTGFGLLADGGQPVSSTRIRALLAAGDVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ2</accession>
    <name>A0A7K0JTQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Family 65 glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_09285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000428">
        <property type="protein sequence ID" value="MST32909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="329"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="745"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="626"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="793" mass="86776" checksum="002D59D86F040632" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ3</accession>
    <name>A0A7K0JTQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="20969" checksum="819CECE3C2EE4126" modified="2021-04-07" version="1">MIYLVRHGQSEWNLLRRTQGWTSHPQLTDLGRRQASVAARAIRADAEANGQPVRSVVASDLVRAVQTAQIVAGALAAPVYIDRRWREQCLGRLEGLGYAETDAELDGNRADPDAPIGGGETARQVAQRAATALGDLDRTEVSVVVTHGDTIRCLLAHLTGIAPTFEAASPVPNGAVIALDSLSGARIRPLVVPSLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW4</accession>
    <name>A0A7K0JTW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-2 C(20)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_09595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="81"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="32741" checksum="3FCD598BF68645F7" modified="2021-04-07" version="1">MAPGERTAGRGDAGRSRATMRKTSVYLSDDLKAALSIAAARSGRSEADTMRLALEAFVRSAGSAPGGERRSRRPIPGGPCLVGVGVGPGDPELLTDRARRILLAADRVLAGSISEDATGRAEAVVHAAAPGVAVERVVLAVGPDVRARRRSLAAAAERIAALLQQGELVAFATLGDPHLYSPFPALANAVQALQPEAVVEAEPGILPFQQLAAATSTTVAQGEERVTVVVLGDEPAELDALFDHDDSTVVIYKGGRELPAVATALARRDRLGAAVAGELLGQPGEGCLPLADLATGPGPYLTTAIVPARRSPAVGERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY6</accession>
    <name>A0A7K0JTY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="25942" checksum="7D5DAE703733C382" modified="2021-04-07" version="1">MPGWSGRADLAQAHLRLAAGHARRGGGPGLRSWLHAVAAECLARSGRVADALVQIERACETLAAGGAHDDPWWLDFYDPRRLDGFDAVVGLATAHAVLSRDATQRDARHARDWVERVLRLLPQPAEGPGLTPQDCVTLLDRAIGTALVGDDDGALRLVETAASTNSLTARVDRPATPEESAARTSSPWALRTGSAVGPIMRSSNRSGGDIELAPLCTSGCERFERRGVWGLAGGADDGVSCVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM2</accession>
    <name>A0A7K0JUM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_11105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000538">
        <property type="protein sequence ID" value="MST33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="270"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="393" mass="40143" checksum="3F714B80A520AEBC" modified="2021-04-07" version="1">MAEVWIVDGVRTPVGRHGGALARVRPDDLAAVAVGALVDRRPDLDPARIDDVLLGDANGAGEDNRNVARMAALLAGLPTSVPGATVNRLCGSGMEAVVEASRAVAVGDASVVVAGGVESMSRAPWVLTKPEAGFARGHETLWSTTLGWRMTNPAMPAEWTVALGEGAEILADEFGIDREAQDRFAAASHAKAAAAWGAGEFGDEVVPVPGAELARDESIRDDTSLEKLGRLRPAFRPDGTVTAGNSSPLNDGASALLLADDAGLEAAGGRPLARIVSRAVSGVEPHRYGIGPVPAAARALERAGLGWGDLASVELNEAFAAQSLACLASWPDLDPDRVNPAGGAIALGHPLGCSGARLLTTLAWRLHRAGGGYGLAAMCIGVGQGIAVVLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ1</accession>
    <name>A0A7K0JUQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_13275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000691">
        <property type="protein sequence ID" value="MST33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="181"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="691" mass="71642" checksum="2C445B5E5A3CBFD2" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU9</accession>
    <name>A0A7K0JUU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_11180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000544">
        <property type="protein sequence ID" value="MST33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="15707" checksum="6E6CAE2CC2A9C1EF" modified="2021-04-07" version="1">GATSALITAQGVGAVAGALALTPLARRVGRRRLLLADLVAVAAALGVYGAAPDLAVAVAAMVVVGSGYIGVLAGCNTIIQLHAPASLRGRVLGIYMMALGVLYPVGALAQGAVAERVGVRAVTIGGAGLLVAAAVLVLRGVIPSTVDRQPVVAASADDAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ7</accession>
    <name>A0A7K0JUZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="12753" checksum="797E4DB3E480A579" modified="2021-04-07" version="1">MPAPRKYDQETRDRAVRLYQERRRDHASESAIESRRRVGELLDIKPETLRGWVERAEIDAGARPGVTTEENSEIARLKKENAELRRANEILKTASAFFAAAELDRCCRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV17</accession>
    <name>A0A7K0JV17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two-component system sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000727">
        <property type="protein sequence ID" value="MST33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="21879" checksum="9A743414D4E0A63B" modified="2021-04-07" version="1" fragment="single">MGGGLRQLVAEKDWSATPLGPKEGWSEALRTTVETCLGSRFPVIIFWGPELVQVYNDAYAPIIGAKHPQALGQTAAACFPEVWDVIGPMLHGVLESGEATWSDDLLLMLERNGFAEECYFTFSYSPAGGAPVEGVFCAVIETTRRVVGERRFDALRELSTALTGAHHVAEVLDAAATTLGRHPPDLPAGLLVRETTAGARDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV63</accession>
    <name>A0A7K0JV63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000746">
        <property type="protein sequence ID" value="MST33850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="28387" checksum="DCB21046AA7BEAF9" modified="2021-04-07" version="1" fragment="single">YQFVVHLKKAYNPNWFTGNQLTWVYPLPQQAWDKTCATCAVGHNASTPAGALKVFNFLYKASSSVSTYSTNPLWKTVDGPWVIKSYNPTTYHTVLAANPRYTGPGKPKLAGYQIYSFSSDTAELDAVRSGTVDFGFIPFSDVGEISHFRSSGYNVEPWSYFYNEDVEFGYTGPWKALVSQLYIRQALQHLVDQPLYLKQALHGFGLADYGIAPDYPGSKYVAPALRTNPYPYSVSAATKLLTSHGWAKGANGIDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV77</accession>
    <name>A0A7K0JV77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000743">
        <property type="protein sequence ID" value="MST33843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="19446" checksum="F09C94CDB0BD7496" modified="2021-04-07" version="1">VLDAALVLMADHEVAASTLAVRAAASFGADPYAAVLTGMAAASGPRHAASSLHVRPVLARAAAQGPAVALGEVLGRGAPLHGFGQPLYPGGDPRATELLGRLRALPIDLTAVDGLLQLAASRRMPPPNCDFALAALAQATSMVPGASEAVFVLARTAGWVAHALEEYEQRTPFRLRAAYVGPRETGDGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB0</accession>
    <name>A0A7K0JVB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000766">
        <property type="protein sequence ID" value="MST33905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="514" mass="54061" checksum="352D5C0036B0ADFF" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD6</accession>
    <name>A0A7K0JVD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">GHK86_14515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000774">
        <property type="protein sequence ID" value="MST33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="19275" checksum="56A9EC750B9FACD9" modified="2021-04-07" version="1">MATGFMRKAMVFLGLDDEELDDYDTAYEPEMAVGSSGSRRYQSEVSEPTIVEPPRGIRPLPREPVQDPSGPVAVPRPRPVVAMPGAKVHMVAPTRFADAQEVGDRFRGGQPVAVNLQTAEDPGLARRMIDFCSGVTYALSGTMDKIADQVFLLTPHGIEVSADEKRRLREQGSFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ7</accession>
    <name>A0A7K0JVJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glu_synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000794">
        <property type="protein sequence ID" value="MST33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14908" checksum="B7D318A78D819D5B" modified="2021-04-07" version="1">GHSALMALNCNKEIPGVTDYEGTIGVPAGKCYHCHTGRCPVGVATQDPELRQRLVVDEAAERVYNFLHTLTLEVQMLARACGKTNIHSLEPEDLCALTVEAAAMAKVPLAGTTYVPGVTEERALAEIKTLLAKHVADLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM7</accession>
    <name>A0A7K0JVM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">der</name>
        <name evidence="12" type="ORF">GHK86_14915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000807">
        <property type="protein sequence ID" value="MST34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="187"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="5"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="52"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="240"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="439" mass="47283" checksum="85B54862FC5B8BF1" modified="2021-04-07" version="1">MAVVGRPNVGKSTLVNRIVGRREAIVEERPGVTRDRKPLDAEWAGREFTIVDTGGWLAADGGLDRAVSAQSERAVAEAAAVLFVVDATIGITDEDAKVARLLRATAAPVLVVANKVDGDSRETDAWAFARLGLGDPHPVSALHGRGTGDLLDDLVAHLPVPPPAGDETVTGPGGGPAPGTDGELRVPAVAIVGRPNVGKSTLFNRLIGDERSVVHDMPGTTRDTIDTVVTTDDGELRFIDTAGMRRRAKEAEGAEYYSLVRALQAIDRADAALLVIDASAGITRQDQRLAERVDAAGNPVVILLNKWETLDPEQRRSVVIDLEDRLSFLAYAPVLKISARTGLGVHKLLPALRKALEAYGRRVPTAELNRVLAEAQAAHRSPHGRILYATQGATDPPTFTLFTSAKLPPTYLRYLERRIREHFGFGPTPLKLRVRRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN7</accession>
    <name>A0A7K0JVN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formamidopyrimidine-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000813">
        <property type="protein sequence ID" value="MST34016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="5">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="15094" checksum="31C1270382E60A1B" modified="2021-04-07" version="1" fragment="single">VPAELAHLGPDALEGVPDAASLGRLLAGRRRRIKPMLLDQQVIAGIGNIYADEILWAARIGPDRPAGALGGAALRRLHPAIRATLLAAIAHRGSSIADEQYRDLAGVVGSYQLHHQAYGREGRPCARCGRPIRRVSDGGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS3</accession>
    <name>A0A7K0JVS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000821">
        <property type="protein sequence ID" value="MST34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="56" mass="6616" checksum="5CA7C7DB44719E01" modified="2021-04-07" version="1" fragment="single">MFLGGEVDVLWNEGVLALFRWRRERRQRLAEAAALVREAERWLAAQHPGSRPDELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV8</accession>
    <name>A0A7K0JVV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000847">
        <property type="protein sequence ID" value="MST34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="152"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="598" mass="64506" checksum="8A96CD3FC1336091" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY1</accession>
    <name>A0A7K0JVY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobA</name>
        <name evidence="9" type="ORF">GHK86_13350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000694">
        <property type="protein sequence ID" value="MST33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="251" mass="25719" checksum="3E1297FE0942A805" modified="2021-04-07" version="1">MTVYLVGAGPGDPGLLTVRGAELLRTADVVLYDRLVRADILTLVRSEALCIDVGKRAGTDTPDADRRQHEIGQLLIEHGRTSAVVVRLKGGDPFVFGRGGEEVEILEEAGIDWQIVPGVTSALGVPGAAGIPVTHRGLASSVTVVTGHTLDSGKTSHPGHEPNWDALARTGGTLVILMGMASRKAVAAALVDAGRAADTPVAVIQDGTTPAQRMVRTTLAGLPDVDLGAPAVIVVGPVVDVAPRAPGAPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ2</accession>
    <name>A0A7K0JVZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pstS</name>
        <name evidence="7" type="ORF">GHK86_15480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000858">
        <property type="protein sequence ID" value="MST34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029774477" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="39"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="82"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="406" mass="41300" checksum="BF51711EDA15699E" modified="2021-04-07" version="1">MHFAKPTRIAVAAAVAALALGACGSNSSSPSSGTGASGSSTTTSTGSASGTSASGTSASGTSGSTSGASGSTAATVYSPPSATVNVSETGSTLLYPLFQEWQKGYHALHGNVSITPQGTGSGTGISDAEAKTIDIGASDAYLPSSAFSQYPGIENIPLAISAQMINYNLPGVSGHLKLSPTVIAKMFYGQITKWNDPAVKALNPGVNLPDLKVVPLHRSDGSGDTFLFSTYMTDGAPNVWKLGYNTTISWPNVPGALSAEGNGGMVTTCGQTKGCIAYIGISYRSETQKAGLGEAMIQNKAGNFVLPSSSTIEAEASSFISQTPKGESLSLIYGPGSDSYPIINYEYAIVNTKMQSASAAQAVKALLSWGLDPSNGSSGTYLDPINFNPLPASVIKLSDAQIAKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW20</accession>
    <name>A0A7K0JW20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000865">
        <property type="protein sequence ID" value="MST34133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="18972" checksum="A35D956DBAEF9A17" modified="2021-04-07" version="1" fragment="single">MPAYVVRLWMPDRPGALGAVASRIGAVRGDLVGIDILERGGGRAIDELVVELPDASLVPLLTSEIGQVDGVDVEDVSPAPEEPVDPRLDALETAAVLVAQIAVPDLLEALARHSMRDFSADWAAVLDPSGPIPLAEVGAVPPVAWLAAFVAGSRVSVTPELVDAGPDDVAWADLPAAELAVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW28</accession>
    <name>A0A7K0JW28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="6" type="ORF">GHK86_13615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000708">
        <property type="protein sequence ID" value="MST33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="68"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="32700" checksum="51CA9C145FD19284" modified="2021-04-07" version="1">MTLEESADGGTGGPLRVSSPTEERNPRTLDIDAVPVLTLLELINDEDATVAGVVRRVLPDLATLVEITVERLRAGGRVHYFGAGTSGRLGLLDAAEIPPTYGLASGVFVAHLAGGDDAFRVAREGSEDDDAQGEAEARAAVAPGDVVIGLASSGYTPYVRGGLRGGRGVGAHTALVTSNPGAPLAAEADTFICVDTGPEVITGSTRMKSGTAQKLVLNTFSTAVMVRTGRTWSNLMVEMVPSNRKLQGRVLRMLGQATGQDEARCEAALSAAGGEAKTALVMLRAGVGAGAAREALTASDNVVAAALDRLRGREGAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW51</accession>
    <name>A0A7K0JW51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">GHK86_15710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000878">
        <property type="protein sequence ID" value="MST34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="4"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="22839" checksum="B1DA6ABEF7E6F3A7" modified="2021-04-07" version="1">MRVIAIDGPAGSGKSTVARAVAAALALDYLDTGAMYRAVTFAAMRRGIDPEDTDLVAELARALSLEVADTVTVDGVDATIEIRSPEVTRAVSTVAANPAVRRELVQRQREWAAAHGGGVIEGRDIGSVVFPDATLKVYLTADDGERAMRRSKEMLNLQYDQVAADIARRDHADSTRQASPLGVADDAVRLDTTSRPVEQVVEEVLRLAAERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW71</accession>
    <name>A0A7K0JW71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000889">
        <property type="protein sequence ID" value="MST34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="3">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="18721" checksum="C9251B76A8CF4ACD" modified="2021-04-07" version="1" fragment="single">MIVQVEPMRPVFGPAETAELSERLDSAIQRLQLPGSPSGDADRWEMGVPDEWLRDLLGAWRRFDVAAFQDRLDALHHLRVSIDGLALHVIQARGHGPAPVPLLLTHGWPGSCLEYLDLIAPLTDPAVHGGHPRNAFDVIIPSLPGYGWSAPPPYGGLTAAQVALLWHRLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW80</accession>
    <name>A0A7K0JW80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">M48 family metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GHK86_13940</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000735">
        <property type="protein sequence ID" value="MST33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="14">
        <location>
            <begin position="215"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="418" mass="45529" checksum="8D0B42F28081F986" modified="2021-04-07" version="1">MVRDPPEVVVTVVLVVVVVVLVALAMGAILAFNGLVRRRNRTREAWAEIEVELERRHDLVPNLVETVRGYASHERGTFEAVTAARAAAVSAGASGDPSTIAPAEDQLGRSLRSLFAVAERYPDLRAVEAFDQLQEQLTATEDKIEFSRRYYNTSARDYDNALQSFPRNLLAEAFGFRPATYFEAPPGDEAAPRVSFDGGGPGGAQPRSPTGITPPQVYVVDDPSPNAFATGVGPRRAAVTVTTGLLALMDREELEGVLAHEMSHIRNYDVRLLLVVSTLIGMAGLLASVVWRTVIVVRPRGRDAEEVVAAMALAGLLLAAVAVVVGPLIRLALSRRREQLADVSAVELTRNPAGLIGALRKLERNDRPMEHVNHATAAMCIDDPLQHHEGWFHRLFDTHPPIRERIAVLEGILEAHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB4</accession>
    <name>A0A7K0JWB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000907">
        <property type="protein sequence ID" value="MST34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ_C" evidence="2">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8034" checksum="6DCE39177EC3C94C" modified="2021-04-07" version="1">PTLDKPVTVKIPAGSRSGRTLRLRGRGVPARSGAGDLLVTVEVAVPTAPTPEQRDLVQSLASVSDGDALRAALFAGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI9</accession>
    <name>A0A7K0JWI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000936">
        <property type="protein sequence ID" value="MST34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="21846" checksum="6BC9624DD1B0B7FB" modified="2021-04-07" version="1">MIDLGSTAVVADRMPLARVGIAAALRLANVVTLELCDNVTVAFDAARRLGAGYLVVGASDEAETDTLRRRLAGSQACVIALVGRVDRDALVGLLDAGVAGVALRTVLPEDLAAMVRSVTAGERAIAPALMSLLVGFEAPAGSPPGAVVASPLTAKEQQVLAHLAQGESNAAIAEALYISPATVKSHLASIYAKLEVRTRHEATSRAVALGLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK3</accession>
    <name>A0A7K0JWK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000946">
        <property type="protein sequence ID" value="MST34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="444"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="661" mass="70491" checksum="035D5C8BF86AF254" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM3</accession>
    <name>A0A7K0JWM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000962">
        <property type="protein sequence ID" value="MST34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="25359" checksum="FD36162C7928FDBB" modified="2021-04-07" version="1">MGATVLQLSDTHLAADPGARVHGRDPARRLAAVVAAVGCPVDLVLLTGDITDDGSDAACRRVADLLAPLGSPVVAVPGNHDAGPEVEAVFGPPLPAELGGWSVVAVSSRLAGRIEGAVEPDDVLDLLDGAGGRPTLLALHHPPAGPSTHPWFQLGGAAGLLAGLATRPQVRLVLSGHLHQPFERRLDDLVLLGAPSTLYAIRHDGDHWHADDSLTCGARLVHLDGGGAWRSELVGIGAEVGAGAPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT3</accession>
    <name>A0A7K0JWT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_16920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000981">
        <property type="protein sequence ID" value="MST34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="212"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="367" mass="39225" checksum="F9E604266301ED5F" modified="2021-04-07" version="1">MIQGTVRSFVDKAVRPNIAAWFEEGVAPRELASELGSLGLFGMHLTGYGCAGTNAVSYGLACLELEAGDSGLRSFVSVQGSLAMYSIWRWGSEEQKQEWLPRLATGEAIGCFGLTEPDFGSNPAGMRTNARRDGGDWILNGAKMWITNGSLADVATVWARTDEGIRGFLVPRGTPGFSAGDIHHKLSLRASATSELSLQDVRLPASAMLPEGRGLSAPLSCLNEARFGIVWGAMGAARDCLNTALAYAGDRVQFDRPIAGFQLTQAKLADAAVELSKGLLLALHLGRLKDQGRLRPEQVSVGKLNNVREAIDIARVCRTVLGAAGITTEYPVLRHANNLESVLTYEGTSEVHQLAIGQALTGIPAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT9</accession>
    <name>A0A7K0JWT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_17010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000994">
        <property type="protein sequence ID" value="MST34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="37034" checksum="C8668FC365FFE023" modified="2021-04-07" version="1" fragment="single">MSQGRGAVTLRAVAARAGVSKSLVSRVLQGSPHVSEERRQAVEAAIRELGYRPNATARSLSQRRTHAVGVLMHDLRQPWFVDFLEGLDRTLHANGLHPLVGDARVDRASNERLLEAFMEMRVDGLVLAGTLPPSTTVAEAAAWLPTVVAGNRDVELPRVDVVAQDDWSGARLALDHLASLGHRRIGHVAGSGGRVFELRRASYEAWMREHGLEDRVAVAGCDTTEEGGYQAARRLLDRRRGRPTALFVANDLPCLGVMAAARELGLQVPDDLAIVGFDNSVLARMRFVALTSVDIAPGRAGELAGTALVERIADPTRPARHQLLTPTLEVRRSSGPPRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV1</accession>
    <name>A0A7K0JWV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000823">
        <property type="protein sequence ID" value="MST34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="369" mass="37271" checksum="603C8FAC45EFCC92" modified="2021-04-07" version="1">MRRGRTARSCKGPRRRGYRPVRSPHGRPPRLAGARRRRYSTYIHTFLLATVGLHVQVGLGIAAGLAALGIVAGWLGAAIGIGGGVIVVPALVLGFGFDTKVAVATSLIAVVATSAAAGSAYAGAGQTNLRLALALEIATTVGGLVGGVVAVLIAPTAIDAVFAAVMLLTAALVLRGRDEHGSVEEADEGDAELTHQASPPAPEAAAGGGVAQLVAAGKRVGWEERGSLGGAYLDQATGTLVRYRAVRLWIGWSVSLLAGMLSGLLGVGGGFLKVPAMHLGMKVPIKVSAATSNFMIGVTAIASLFVYFARGYVLPLAAAPVAVGIALGAYAGARSSQRVSAATLRRILAVVLVLVAVQMGLKAVGGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX09</accession>
    <name>A0A7K0JX09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001030">
        <property type="protein sequence ID" value="MST34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="15708" checksum="DC2754ECAE74F81D" modified="2021-04-07" version="1">MHLELEHDYRFRADFGAGLPALHLDEPPPLGAGSGPNASAALGAAVGNCLSASLLYCLRRAHVDVEGMTTDVEVSLARNEHGRLRVGAIRVQVSPQLADGAEGRVGRCLELFEDFCVVTEAVREGIDVDVTVAGLTGDGGHDAPAASQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD9</accession>
    <name>A0A7K0JXD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_18050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001103">
        <property type="protein sequence ID" value="MST34617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13161" checksum="8323CC5A3E3A46AE" modified="2021-04-07" version="1" fragment="single">AEQALVAVICQAYVEGVSTRRVEDLVQAMGIEGISKSEVSRIAAELDALVAEFLSRPLDAGPYKYLWIDALTHRVREGGRVVSVSTVIATVVNAEGRREIAGVAVVTSEDTASWTEFLRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE1</accession>
    <name>A0A7K0JXE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001109">
        <property type="protein sequence ID" value="MST34625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="24602" checksum="E3D51DCC38CA2BE1" modified="2021-04-07" version="1">MSDASAVSRADPLWMRDCRAYVVQADLDEPCRRRLAEVQDRLTGVLPGSVICPPASLHVSVAVLLSVRRDYPAPKDALWAQWGSRWCDQLRALAEGFPPFELRFERLEVSQAAVIALADPVAAVESLRRRAAALQQDAGLVSYQPSIVHCTLLRYGTSGLQLSGLDRVARAVPLQARTVVRQLTVRRELVYPSVVSEAVDRFDLWGRPPDDGRRPPLRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG3</accession>
    <name>A0A7K0JXG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001121">
        <property type="protein sequence ID" value="MST34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="28538" checksum="944C4BC41074996F" modified="2021-04-07" version="1" fragment="single">MEEGEGVTSATHRPVPFLEVEGLSAGYNRVPIVHDVSVRVGLGEVALVMGPNGAGKSTLIKAITGELAALSGRIVLDGRDVTRLREEDRNAAGIGYVPQVRDVFGPLTVSENLEMGGYRLKKAEIAERESEIFELFPQLPPLRRRVARTLSGGERKMLAIGRALMAQPRLVVLDEPTAGLAPGIARSVLHDIVARLAESGRALLLIEQRVSLGLEVASWGYVLTDGRLRLEESCADLRARPDLATLFLGQGGVRMAGAGQPGGAHVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL7</accession>
    <name>A0A7K0JXL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001158">
        <property type="protein sequence ID" value="MST34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="7604" checksum="32FE5F6E8977D805" modified="2021-04-07" version="1">MAVGRDATRVGDPTPGEGEFCEPVVVPLVSFRRQLAAGCLTDTDLGYLALDHLGLLGGGPPGAAARPEGSQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM7</accession>
    <name>A0A7K0JXM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001167">
        <property type="protein sequence ID" value="MST34708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="220" mass="23149" checksum="3C272D61669D0D7D" modified="2021-04-07" version="1" fragment="single">MPPSSLAPAPDVAVSFGQALLDNLGRVVRGAPGALTAAVVAALAGGHLLIEDVPGVGKTVLARALAASLGAELSRVQGHPDLLPSDVTGVAVYSPGKESWEFRPGPVFAHVVLADELNRTPPRTQSALLEAMEEHQVSVDGRSWPLPDPHMVIATQNPVSQRGTFPLVESQLDRFACATSIGYPDAEAEARLVLQDGGRAALERLAPVADVRAWREVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS4</accession>
    <name>A0A7K0JXS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001191">
        <property type="protein sequence ID" value="MST34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="385" mass="41171" checksum="C6DCE8AC91956F12" modified="2021-04-07" version="1" fragment="single">MSLLAAVDGASPILPPVRTGSVLWYGPYLNPSGYGEEARGFLGPLQQAGWSICARSSGDDSVAFAGSLQGSPFEASLGQALVLQPVDPVIAVIHLPGSAAQPVRGAVRTVMRTMFETDGLPPGWAGVLNGVDEIWVPSAFNVETFRRAGVTVPLHVVPGGVDTELFRPDVAPLAVPGARGRVYLSVFEWSHRKAPDVLLRAWAAAFGPGDPVSLVLRCFPRDRFDGDTTAAVEALVDEELARLGRSRADVAPIVCLGESLPPGAMPHLMAAADVYLGVARGEGWGRPLLEAMATGLAVVGTRWSGNLAFMDDDNSLLVDVERLVEIDERMDLDFYRGQRWAEPSVEHLVDILRRTADDRGLVEAVGARARADADGRWRWTHAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS7</accession>
    <name>A0A7K0JXS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001197">
        <property type="protein sequence ID" value="MST34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="41"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="20429" checksum="12B74700FBDDB8F6" modified="2021-04-07" version="1">MGAASACRPGASTAPRSALRCRQSEEEERRVPADPPRTTSRILLVEDDPGDVLIITEALEQARLDHELFTVSDGDAALDYLYRRPPFEAALRPDLVMLDLNLPRRNGREVLAEVKAHQGLRSIPIVVLTTSEAEEDIVRAYDLHANAYVPKPVDFAEFVRVINQIDDFYLTVARLPPRSDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT4</accession>
    <name>A0A7K0JXT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000949">
        <property type="protein sequence ID" value="MST34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="320" mass="34900" checksum="FBBC8A0E2EBBBFEB" modified="2021-04-07" version="1" fragment="single">GATYPTGTQPGLMIFDRNGWLVFFRPQTPKDAQPFNFQVQTYNGQPVLTWFQGTLGPGFGTAGQYFLADAAYRTIRTVQGSNGIPPDLHEFLLTAEGTALHTAYEYLPDQKLYNGHAMEVDVATGALVFDWSCYPAVPVAKTFLPGNADYFHINSIDLWPGSARNLLVSSRNTSAVYLIERASGQILWQAGGKGSSFAMEGPGTRYEYQHDARALPDGSGFSVFDDASPPSPERQAWAKVLQVDTAAGQVRLAQQMPHTTLPLVVDSQGNNQLLADGSRFVGWGADPYFSQYDPTGTMVLDGRFPAGVESYRTFTASWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT6</accession>
    <name>A0A7K0JXT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001197">
        <property type="protein sequence ID" value="MST34757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="903" mass="101598" checksum="96B6B963E5B26EDD" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY5</accession>
    <name>A0A7K0JXY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_19070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001232">
        <property type="protein sequence ID" value="MST34816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="25807" checksum="923145C5FDA2D939" modified="2021-04-07" version="1">MSATVLIVEDELKLRDLLRRYLERESLTVLTAGTGADAIALGLGADLDAVVLDLGLPDIPGEHVAAELRRSGDPPILILSARASDDDRVRGLELGADDYLTKPFNPRELVLRVQALLRRGRADGTAAEARSFGEGMLLVDEGRHEIQVKGLPVELSRSEWGILLTLARVPGRVYSRYELVNAVRGYEWSGYERVVDTHIKNLRRKLDETSDGSGRLIVQTVVGAGYRLGLAADRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY00</accession>
    <name>A0A7K0JY00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001248">
        <property type="protein sequence ID" value="MST34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="32444" checksum="455E3C5049DAF480" modified="2021-04-07" version="1" fragment="single">PHNAPADLFTVRTTHPSYWQLTTLDEFSGSSWAPGQVTYVGIGSQLPGTRAPGPGRQRETFTVQSLGSPWLPTGLDPLAIHSATPDLQYSARTGSILSPRSTSDGLHYTVTSSRALLHLTTADLAALPRLQRNQAPPRSLQLPTDLPRSVGRLARRITAGAHTEVAEALALQAYFHGARFHYSLHPPIDGSGVEALTGFLFVTHTGYCQQFAASFAALARSVGLPTRLAVGFTTGTPIGHHTYEVTDADVHTWPEVWFPKVGWVPFEPTKGSGRSAFAIPGAPWTGAGGGGTPALVTAGTGGVGAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB4</accession>
    <name>A0A7K0JYB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001307">
        <property type="protein sequence ID" value="MST34927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="205" mass="21158" checksum="8DD57C9713886D59" modified="2021-04-07" version="1">GIGSAPVRLDHVAADTAERLGYLFERRGVALGADLHPVTVSGDADRLGQVTANLLANAARYTPPGGTVQLAVTAESGVATVTVTDTGPGVAPEERERIFDRFVRGAAASGTAGSGIGLAVVRELVTAHGGQVRVTDGPGGGSRFVVTLPAVPAAPDLTATTHDPDIHPTGGVSHGNWIHHTARIHPQQPRRNQSHGQHHPRILPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB5</accession>
    <name>A0A7K0JYB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001316">
        <property type="protein sequence ID" value="MST34940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA_C" evidence="1">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="18397" checksum="A8FD1557B3493B70" modified="2021-04-07" version="1">VVRLVEGDRFPLGELDGERTPRARQIAELFTGAGFKSRVVADIRAQIWIKALGNVAMNPISTLTRAALDEITGFEPTRGLAAQMMGEASAVADELGLRVRMSVEKRLAGIDEVGAHKTSMLQDLEAGRPLEIEPIIGSVVEIGRLTGTAMPATEAVYALLSLLERHRATGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD4</accession>
    <name>A0A7K0JYD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001060">
        <property type="protein sequence ID" value="MST34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="15239" checksum="ACBB3CE0FF9B3191" modified="2021-04-07" version="1" fragment="single">MPDLAVPVGDTDLPAYLALPPVGTGPWPAVVVVHDAFGLTDHTREHADRLAAAGYVAVVPDLYGRGSAVRCVRQTFRELGARRGRAFDDLEAVRTWAASRPDTTGKVGVIGFCMGGGFALALRIFRAARIVVDTALHTGGMTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH8</accession>
    <name>A0A7K0JYH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001311">
        <property type="protein sequence ID" value="MST34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="36363" checksum="124A91B0B51C7364" modified="2021-04-07" version="1">MLRPNLLQLPDARALVAAPRAPRVSGRRHRRGGTFVQDGSTEPGDTGRRGPREDRCAGEVRENTAGDSVAGSARRADGDVRLVEDGKQEAPAVLLLGNAAASTYCWDPVVPLLASSFRVLRVDLLGNRGSANPPGGHDVSSQARRVAAALDGIGVSRVVVIGHSSGCTVATAFAEQRPEAVAAVALLDFGPGLADKLPEPLAVRLLLTRVPGRVLWRLRTKDAVRKAARGSFVRPVEIPDAWIDHVLRMTHREFVNALRAPVDYLDERSLPDRLRALGLPLLVVFGADDGRWRASSARSYECVPGARVEVLPGVGHTSMMEDPETTGRLLAEFATATAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI9</accession>
    <name>A0A7K0JYI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4255 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001089">
        <property type="protein sequence ID" value="MST34594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="24043" checksum="8296F0136599D7A5" modified="2021-04-07" version="1" fragment="single">MIQHVDRALERLLRLSPALGESLVDISFDAPDRTWGAARTRPTVNAFLWEISRNPMYRSAGVQLLRDVDSGAVVGRRPVTPVVDLHYMLTAWTTEKRDEHQLLGALVECVLAHQELPDGVLPEPLAGKKCRVQLAPHEKRPPGEFWSALDGRLRPGVQLEISIPLEVFSWTPMAPPPTSVAVSASRLPEPAGPDEPGRAILARRRANGAVVMEGRTAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK9</accession>
    <name>A0A7K0JYK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AURKAIP1/COX24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001108">
        <property type="protein sequence ID" value="MST34624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="32" mass="4050" checksum="2ACD592DA3055124" modified="2021-04-07" version="1">MGSLIKKRRKRMRKKKHKKMLKATRWQRRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR5</accession>
    <name>A0A7K0JYR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001418">
        <property type="protein sequence ID" value="MST35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="10576" checksum="5E09ABE16545A258" modified="2021-04-07" version="1" fragment="single">MPPTAADAVLPVLHEVVTAIRRELDGLDDWGLVGTSDAQYRHDLVADRVGVDLLDAAGFGILSEESGLHRPERDVVVVIDPVDGSTNASRGLPWYATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ8</accession>
    <name>A0A7K0JYZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ORF">GHK86_20840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001483">
        <property type="protein sequence ID" value="MST35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="34921" checksum="EFC2398D6F03E2EF" modified="2021-04-07" version="1">MTPEPPAPEPIGPPDGRRVPRFAAPDTFARLPTLDAVGAAAVAVVGVPFDAGVSYRPGARFGPQAVRAGSKLLRPYHPALGVEPWRVQQVADAGDLAVNPFDIAGAIEAVAAGAADLLGRAGHLVAIGGDHTIALPLLRATAARHGPVALVHFDAHLDTWDTYFDAPYTHGTPFRRAVEEGVLALEASAHVGIRGPLYAPRDLIEDHDLGFATVTTLEVAERGVADALARIKARVGGRPVYVSVDIDVLDPAHAPGTGTPEPGGLTSRELLALLRGLDGVHLVGADVVEVSPAYDHAELTALAAANVVYDLLGLFALQAGRQPAGRRSAGGAPATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ54</accession>
    <name>A0A7K0JZ54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001551">
        <property type="protein sequence ID" value="MST35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="10441" checksum="0EE6D177984413BF" modified="2021-04-07" version="1" fragment="single">MATCVATLAASARSPATQASRSADAETDGVAGRAAGNVVVVVVLVLVEVLVGGGTVVVGGSVVGGLDAVDVVGSGGLPLAALPHAAPTRPRPATRATIPSARLPSARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD7</accession>
    <name>A0A7K0JZD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001634">
        <property type="protein sequence ID" value="MST35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="131" mass="14157" checksum="6229B650A99C23CC" modified="2021-04-07" version="1">VPQLEADLREVYLGEWEGGAYRRHAAEGHPIARRVLAEERWDVIPGAERAADFDARVRAGIGRIARRHPDELVAAVTHGGVIGSVLAQATGSRPFAFVGADNASISLVVVAGDRWLLRVFNDTGHLTHGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG7</accession>
    <name>A0A7K0JZG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_21845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001667">
        <property type="protein sequence ID" value="MST35361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="4">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="13968" checksum="77FBBB820CC26099" modified="2021-04-07" version="1">MPAYRISQAARLLGVSDDTVRRWADSGRLPVTRDESGRRSIDGAALADFAAGLIEDGADPAAGRHSSRNRLTGIVTNVVRDQVMAQVEMVAGPFRVVSLISREAADQLGLERGVVAVASVKATSVSIELPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZJ8</accession>
    <name>A0A7K0JZJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001683">
        <property type="protein sequence ID" value="MST35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="16139" checksum="DE67692BEA03DFCA" modified="2021-04-07" version="1" fragment="single">MSVPSPTARGRRRRRDEGLPGFEEYLAESGNALFRLAVVLSSDVRAGEDLYQETLDRLARHWGTLDNPSAWARRVMHNLAVDRHRSRRARLTEVPSTDAAEPPDVASGDPLEAAELRPLLLAALRDLSDAQRLVVALRYLEDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZL9</accession>
    <name>A0A7K0JZL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001372">
        <property type="protein sequence ID" value="MST35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="36770" checksum="EC52B811610DFD41" modified="2021-04-07" version="1" fragment="single">GHYDFAVPAGATAWGRIAARVVAAGYDGWMEDFGEYTPLDARTGDGSSGTGAHNRYPTQFHAAAAGEAAALEAVAGRRLARFVRSGWTGTAPVAPIVWGGDPTCGWGFDGLASAVIQLLSMAASGIALWGSDTGGFFSGEQRLTPELLVRWIQFSAFCPLMRTKAAGVELPPYRRPQIWDDDVRPHWARWSVWHTRLNDYLMAAHDEYRETGRPIACPLPLVEPGLPGGTLDDEYLLGRDLLVAPVLHPGATSRSVTFPSGPWVDLWHPDRPVIVGPTRRDVAVEPDEIPVWLRGGAVLGLLPDTVASLAPYGPGVPPRRDLWVYPTAAWQGRLGPGIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZS9</accession>
    <name>A0A7K0JZS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001410">
        <property type="protein sequence ID" value="MST35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="24488" checksum="510EDD496D6103CA" modified="2021-04-07" version="1" fragment="single">TTAPSGSASAPAGSAAALDRAFVAAVARVRPDVVEISTSSGLGSGVVYDHRGDIVTNDHVVGSATTFTVHLADGRTVAATLVGRYAPDDLAVIRARSTDGLSPATFGNSATVLVGAIVFAVGNPLGLASSVTQGIVSYNGRPVSEGNGVTLPSTIQTSAPINPGNSGGALVDLAGKVIGIPTLAAVSQQSGGEAVGIGFAIPSKTVQLIVPQLIATGHVAHSDRAALGIQGGDAVDASGAPAGVIVAAVTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZX1</accession>
    <name>A0A7K0JZX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001435">
        <property type="protein sequence ID" value="MST35104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5355" checksum="97DC9D7BA13BE4ED" modified="2021-04-07" version="1">GHDAAILAAHVPAAMLFVRNPTGTSHDPAESATVEDCLAGVDALTAVLEDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0S5</accession>
    <name>A0A7K0K0S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001679">
        <property type="protein sequence ID" value="MST35374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="61"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="24630" checksum="A0DC8E24520AC878" modified="2021-04-07" version="1" fragment="single">QVVAAAAGGRHVFCEKPLAPDLAGVDAAVAAVDRAGVVLHVGFNRRFDPSFSGLAATMASGRLGRLLQLRITSRDPEPPPPSYPRGPGGLFSDMAIHDFDVARFVSGEEVVAVSAAGASLVDPLAGAAGDIDVATIILHLASGAIGLIECCRQSTYGYDQRVEVHGSDATAWSTNPLPSTNVMADGAGAVTVPLHRFFPERYEQAYPAELAAFLAACRGGEPSGPAPATGTDARAALVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0W0</accession>
    <name>A0A7K0K0W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001697">
        <property type="protein sequence ID" value="MST35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="65" mass="6639" checksum="F8F1B57FA97BB39A" modified="2021-04-07" version="1" fragment="single">MVASPPASMDALADDLERLDAAAVTAGVEALAESGTPLDELLDAMLLPAWDRVDARCRAGEADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMG1</accession>
    <name>A0A7K0JMG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000008">
        <property type="protein sequence ID" value="MST31152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="8232" checksum="40D62C36BAC3D78C" modified="2021-04-07" version="1" fragment="single">MAPPADDEDVASGPLDGRVGLRELRALVAVADTGSFRRAAERLGYTQSAVSHQIAVLETALGAALFTRPGGRAAVALTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMJ3</accession>
    <name>A0A7K0JMJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029739551" evidence="1">
        <location>
            <begin position="43"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="410" mass="41389" checksum="9906FD9DC3567763" modified="2021-04-07" version="1">MLKRASLRRRAPHDERGSLIVVLLVILVLATLAAALLTQVVASDKTAFSAQNHDAAVAAAEAGVSDALFRLDQQTGSSPDFCVLGTGKSTITSTDCPSPVATSVPGAGDVSYLASYDRSTGRYTIRSEAWVNGSEGAVQVTATHTVAYPFAVYGQTKLKFDGTNEFRYYNDANPQSDDNPASSGTGGTTVAIGTAGQVDCTGGVGSVETVLYTSAASQTNCPDVQAPAGNYAMPSTTAPSGALACPGTGTGGGTIGSSGSTTYLPAGTYLCATAVTLSGTIDLTGPVKLYIAPPAGTTNALTISGGAEVNVPAAPALPQASLLQIFSGSTAGFGNYNGAGTFTFGGTIDAPNGNLVGDGCKSTFYGSLVLNTDTCNGAHLSMYYDTSLSSLYSSWSISGYTEIPASDVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMK1</accession>
    <name>A0A7K0JMK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000016">
        <property type="protein sequence ID" value="MST31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="114"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="282"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="459"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="635" mass="66847" checksum="DDEA50BF0E35A3F3" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMR2</accession>
    <name>A0A7K0JMR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="482" mass="51113" checksum="97DE7F7FE510560A" modified="2021-04-07" version="1">MATNPSPPGSVRFARRSTRGLLLGFSTPRVIALGVAISIAVAALFTAGAMGFVVTGIIWMPLAATAVVRVAGRPAIEWSATAVHYGARKAGGQDQFRARPTKPRPAGTLALPGDTASLRLHIDEAAGAAMIHDPHRQTLTAVLPVSHPAFALLDDADRAGRVGRWGRVLAGLASSGTCAAIQVLESTVPDPARGQHEWWAAHGTHDGGWADIQYRALLDQVCLDSSTHRTTISLSLDMRAAARAIRAAGRGVKGAAEVLRGDMAGLADGLRSAGLRPGRWLGEADLAALVRHVFDPTIQLDSRADPGANLGRAGPMAVSETWDRLRHDSAWSQVLWIAEWPRISVPPDFLHPLVFAPGVRRSLSLVARPVATDAALRQIRREKTEAVADSAQKAKIGQLADLSDAQEYDDLLARERSIISGHTDVIFTGFVTVTARSAETLEAACATIARAAGQAACEIRPLYGHQLQAFVAATLPLARTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMZ5</accession>
    <name>A0A7K0JMZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_01085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="196"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="28106" checksum="171D6FBDBE9D9A5A" modified="2021-04-07" version="1">MTPTPSQRDELRAKFVEYAETGDVALRDELVAAHLGLAEYLARRFANRGEPLDDLVQVASLGLLKAVGRFDASRGVEFSTYATHTIVGELKRHFRDKGWAIRAPRRMQELYLRLGKVVATLGQELGRSPTIAELAAEVEVSEEEVLEALEAGQAYRFASLDAPVAGDGESETLGARMGAEDPEMEDAERRATLSPLLRQLPERERLILHLRFFDGLTQSEIASRLGISQMHVSRLLARSVAQLRSSADLPSAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN74</accession>
    <name>A0A7K0JN74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000044">
        <property type="protein sequence ID" value="MST31353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="32788" checksum="35D9AE5B41E36CB5" modified="2021-04-07" version="1">RWTHAAGVASARLEALSASPADPPGERAHAGITATTNREPAPEAGETGVAGVELYQLTAQALEGLHQVVSQLAGAVAELQRHVPVFSASSLPVPAELVIAQADGRPAIGYVDGSTAPGYRGFEDVFRGSEELIRQRQRYYLPYLVDRAPVLDVGAGRGEMLELLRQAGVPAIGVDTDVTMAERARQKGLDVRCADAVDVLSALDAGGVGAVFSAQVIEHLDHGALGAMLQAARRALAPNGVFIAETVNPHCPAARKNFWLDPTHRTPIFPEVAVSLCRQAGFARAVVVFPGGTGELATDLLTMPDYAVIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH2</accession>
    <name>A0A7K0JNH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000006">
        <property type="protein sequence ID" value="MST31144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="10522" checksum="08F8798B62DEA5ED" modified="2021-04-07" version="1">MFVCLDGSPPGQDAAAWAEALAASTGADLIADEAERLGSLASPPDLVVVGAAAGQWYPALHLDQPAHALVARAGWPLAVVPGGAPPGVRHLVVGVDGTPASLDALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ5</accession>
    <name>A0A7K0JNJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000064">
        <property type="protein sequence ID" value="MST31421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="85"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="28802" checksum="D58946149E97D166" modified="2021-04-07" version="1">MLDPVPRRGEVAPGRRSRAPVRAAGEKAWWLLRDPAARRAVWLWRRHPANLFQPFNDTGTDRYPEVFSCLRSALARVERPLVVSFGCSTGQEVFTLRQYLPSARLIGLDINPANIRDARRALAGAPDGDVRFEVAGDTASIPSGAADAVVAMAVFRHGDLAEHPSPSCSHRLRFAAFERTLADIDRCLRPGGLLAIEFSSFRFADARTAEGYDCVLAVQRPPHPRVPLYGPDEQLLEDQRYGELVFAKRGGGPGSVPPAPGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU1</accession>
    <name>A0A7K0JNU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="3" type="ORF">GHK86_02275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10131" checksum="E2F9008138DC83E7" modified="2021-04-07" version="1">MAAGAEDALEDGAATPAGDRSRDVLEYLARSLTDEPDAVRIEESPTRNGTRLSLQVAPDDMGRVIGRRGRVAQAIRTVVRAAAAAEGRDVSVDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP88</accession>
    <name>A0A7K0JP88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000137">
        <property type="protein sequence ID" value="MST31790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="543" mass="59018" checksum="EF7F71E8A9FC2CAB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD0</accession>
    <name>A0A7K0JPD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000128">
        <property type="protein sequence ID" value="MST31747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="134" mass="15266" checksum="141801679CAB2BB5" modified="2021-04-07" version="1">MDYHPSSIEEAGPFLRGRQRAVLSTIGPDGGPHQVVVDYALDAEGILLNGRVDRRWVRNLRRDPRASALVHDPADVSHWVRLTGAARLLREGDEEAVEDAMVMARRYGDDPEQFRGQHRVSWRLVPHQVLERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF3</accession>
    <name>A0A7K0JPF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="344" mass="37087" checksum="4AF6B2BE6AB13E7E" modified="2021-04-07" version="1">MDYRTLGRSGTAVSTLALGTMTFGSETDEAAAHAQLDRFVEAGGTLVDTADVYGGGASEEIIGRWIAQRPADIRDRVVLATKGRFPVSDEPNGVGLSRRHLRRALEASLRRLGVDCVDLYQVHAFDALTPLEETLGCLDDLVRSGRIHYVGLSNFTGWQLQRAVDLAEFRHLTPPVTLQPQYNLLTRQVEWELVPACLAAGIGILPWSPLAGGWLTGKYARDERPSGATRLGEDPDRGMEAYGPRAAEHRTWQVVDAVRDVASGRGVSMAQVAIAWLAARPAVSSVILGARTLEQLEDNLGAAGLHLEAAEIDRLDGASAVPVGDYPYGPLGVQQRHRPIAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT0</accession>
    <name>A0A7K0JPT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar type III secretion system protein FlhB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flhB</name>
        <name evidence="3" type="ORF">GHK86_02310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000096">
        <property type="protein sequence ID" value="MST31564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="386" mass="41177" checksum="CD245D3BF4D1996C" modified="2021-04-07" version="1" fragment="single">MAGDRSQRTEKATPKKLQEARKDGMIARSPELSGWGMVLLATVLVPALVRKGYALTARLLAQGSDAMAQPTASADLRLLGAGLSGYFDTLLPVAGVFVALAVVVGLLQTRGTLSPGALRPKVSHLNPIAGLRNLWSPQSVWQTAKSLLRVGLLAFVGYRAIQGVLSPLLGQGAMDLLSSWALAERTALSVTRTVAAVSLGIAFADYVFQRRRMAKQLKMTKQEVKDEARQYDGNPIVKQEIRRRARSLSRKRMIAAIASADALVVNPTHVAVALKYDPGSGAPRVVAKGADELAARLRLEAEIHEVPLVRDVPLARALYGACDLGQEIPPELYEAVAKLLTFLYSLRASGRLRRIDGGAHAPLASFLPGAGRADSPVDSLDGDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU8</accession>
    <name>A0A7K0JPU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000187">
        <property type="protein sequence ID" value="MST31976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="527" mass="57274" checksum="F7AA1FF04D45F1FF" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ28</accession>
    <name>A0A7K0JQ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000202">
        <property type="protein sequence ID" value="MST32058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="182"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="4">
        <location>
            <begin position="431"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="580" mass="62697" checksum="1D8C6045F7C446FB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ40</accession>
    <name>A0A7K0JQ40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000203">
        <property type="protein sequence ID" value="MST32066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="17014" checksum="258D907397AF692A" modified="2021-04-07" version="1">MCIDPAKRYSAEMVTSKGTMTIALDPIAAPKTVNNFVFLARYHYFEGIVFHRVIPGFVLQGGDPTGTGRGGPGYRFEDELPPAGRYEVGSLAMANAGPDTNGSQFFVISGPQGVRLPPQYSLFGKVVSGLDVVATIDQLGSGSGKPKEAVTIESVTVTEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ64</accession>
    <name>A0A7K0JQ64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="27521" checksum="E90A8DED562804AA" modified="2021-04-07" version="1">MALLMAWRTIAWVRRRRRPSWEQMSGNPPLRRRPRRHRRFGDYRRRREAAETARAFVAMIAAGGHDPVAHLGAGVVLQPGESPWVHARARLATWDTHVVQVSSRRVRWWGRRVENVAREMTLRGWQDRGEGDWLITSLRLVGRTRPDGELTSIWWSGLAGVQLDLGADTVHLDGNNGWRGELIGPGVAPIAVAAVAACHGPEALLVHPGLARLRGSGTQAETSPAPEPLALGPGDRMPSTWSQERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ81</accession>
    <name>A0A7K0JQ81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_04945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000205">
        <property type="protein sequence ID" value="MST32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="7">
        <location>
            <begin position="161"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="42191" checksum="0C86BB244907FC47" modified="2021-04-07" version="1">MSAGRGSYLSVTWTDEVTGREGYLVVDRLIRGLASGGLRMRDGCTVEEVRGLAEAMTRKEALNYTPGARYIPLGGAKGGIDCDPRSDEAQGMLTRYLVAMGPYLERVWATGEDLGLTQTMIDRAVADAGLESSIQALDPYLDDPDRAKARLAAGFAVTVDGVGLDTLVGGYGVAAAALVALDQLDRPRAATRAFIQGFGSMGGATARYLVKAGVAVVGVSDADGVIANPDGLDVEHLLRHRDHLGAIDRSALGAADTQLPRDAWLDVDAELLVPAAVSYAIDAVDADRVRAGLVVEAANLPVTPPAEAALTARGVTIVPDVVANSATNSWWWWTLFGDIGPTADEAFARIDTAMGDLVGRLFDRSAKDGTTLRAAAHAIAEENHADLVERWGRRRPADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG2</accession>
    <name>A0A7K0JQG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp/Glu/hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000226">
        <property type="protein sequence ID" value="MST32161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029558249" evidence="1">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="26257" checksum="C3AD66E206D5FDD8" modified="2021-04-07" version="1">MRVLVVNVNTSASMTATIARAARRNASAGTEIVALQPAFGAEGVDCAFESYLAAVGVIDRVVTYRERYDAVVLAGFGEHGRDGLQELIDAPVVEICEAAAHAAMMVGRTYSVVTTPRRSAAAVEDRLRLAGLDQRCASVRATDLGTAEIDRDPVLAMEAIIGEARLAVEEDHAEVICLGCAGMAGLEEAITESLGVPVIDGVGAAVRFVEALVGLNLRTSKVGAYAPPERKEIMGWPLSHHLQLGGPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM8</accession>
    <name>A0A7K0JQM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="321" mass="33292" checksum="41B9EF13D94F95EA" modified="2021-04-07" version="1">MRAAHYERTGPAAEVLHVGEVDRPEPGPGEVRARVTVSAINPTDVKSRAGVTPRPIEELQIPHQDGAGVIDAVGAGVDPGRVGERVWLWLAATRRWGTAAEYTVVPAEQAVALPDGVSDELGASLGVPAVTAHHALFADGPLAGASVLVAGGAGAVGHFAIQLAKRAGARVATTVSGPEKAELARAAGADLVVNYHDADAADRLHDWAPRVDRVVEVDLGANLDLDLRLAGPGTSVVVYAATPEDPTLPVRRCMTANVVLRFMLLYGIPREDLLRSVDEVAAAAAAGALSELPAHRFALDDIVAAHEAAESGVVGKVFVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS2</accession>
    <name>A0A7K0JQS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000263">
        <property type="protein sequence ID" value="MST32282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="16906" checksum="0D61D6FE7292A985" modified="2021-04-07" version="1">MHDGDVHEAGDVRPGLTRRRVLQGAVVAGGAVWAAPVVESFVTAAAAASAPALPFSYILSAQQVSSTDTGIPQLTVNVSFTNTSSFTEQVAFAGHVQYGTTTKALGLIAVDVAAHSAMPTIAKTYVLTGATSGEQVTVKLTITVQPLATGQSKSHVTVSKTIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU2</accession>
    <name>A0A7K0JQU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lepB</name>
        <name evidence="7" type="ORF">GHK86_06160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="WJHE01000267">
        <property type="protein sequence ID" value="MST32306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="20331" checksum="679BC4C09AD7DDE4" modified="2021-04-07" version="1">VEWIVILAVALLAALVVKTWVLQAFVIPSGSMEPTIKIGDRVLVDKLAYDFKPVKAGNIIVFRKPATDITGGNIKDLIKRVVGLPGQTLRSGPHGEIYVDGRLLHQPWLSAAARRSPGPPICDPGPSYSHVDCVGSTLHLPKGEYFVMGDNRGDSDDSRYWGPVSSNLIVGQAFLRIWPPSRIHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV5</accession>
    <name>A0A7K0JQV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="10889" checksum="68D0D4F7652B9CAF" modified="2021-04-07" version="1">MPLSRSAALKAVIADCNEGPGTRLVVAGLVKGPDNTGSPLYWAVFVDPPGKHIAPSAETPALATRLNWIGGFVPVRAPAQLFCDFGHASNLPRLPVFEHSPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX7</accession>
    <name>A0A7K0JQX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FA_desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000275">
        <property type="protein sequence ID" value="MST32346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="34475" checksum="D49CC562FFE24903" modified="2021-04-07" version="1" fragment="single">MATTMVPGPELLPAVLPTDRLSARARPLPPIREELRRIANRRNAVTVAGALLQSVGVVVAAAAVDRWWAYVAAVLLAGRGFALLNILGHEAAHRLLFDDRRANDAVGRWLLAYPALTPFDLYRRAHMAHHRDELGPDEPDRRLYAGYPVTRASWARKLLRDAVGVSGWKNLRPLLAALGERGRRPVALRILAAQLAVAAVLTAAGVLLAGAWWLYPLCWLLPWMTVWRVLNRLRAVAEHGGMARSDDRRVTTHVVRQRPVARFWMVPYHTGWHLAHHVDAGIPWRNLPELHRELVRAGWVTPGLEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR55</accession>
    <name>A0A7K0JR55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000208">
        <property type="protein sequence ID" value="MST32079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="2">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="332" mass="34809" checksum="A00E97B4018F4BFC" modified="2021-04-07" version="1">MSAHRIAVIPGDGIGTEVVPEALKVARAAGADLEAVTYDLGGRRYLATGEVLPDAVLEELRGFDAILLGAIGTPEVPPGLLERGLLLRLRFALDLYVNLRPFRAAASVGAGVPLDVAVVRENTEGTYAGEGGFLRKGTAQEVATQGSVNTRFGVERCVRYAFGLARTRRQHLTLVHKTNVLTFAGDLWQRTFEAVAAEHPDVTTAYQHVDAACIHFVESPQRYDVIVTDNLFGDILTDLAGAVAGGIGRAASANLNPDRTGPSMFEPVHGSAPDIAGTGTADPTAAVVSAAMMLDFLGEADAAARITKAVADLAPERGRSTAATGDAIAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB0</accession>
    <name>A0A7K0JRB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="19732" checksum="7BDD6D9109267AA8" modified="2021-04-07" version="1">MFDLDELLDEYDRARAYTDTLWRDLSEDEVRWRPRPAFSPIGWHLGHQAAVAHFMVRNLTAAEPSPDADLEPIMDSANPEEDRGALPSSERIAGYRTAVAARVHARLRDIDQGRVHAPAQLRIVGRHLLVALINHEYQHDQWISEVRAGELGRPLPSAPVSDRLSEIDGYTVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE0</accession>
    <name>A0A7K0JRE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_07165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="PTHR31937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="18547" checksum="E49C4ADB2BC2C95B" modified="2021-04-07" version="1">MCAEATLGLWQGLTAGSIALTGWALGSGVEGVASVIVVWRFSGPRAVSETAERRARKAVAVSFWLLAPYVAAEAVRDLVVHHHAATTVIGMAVAGSSLLLMPALGRTKRRLAARLDSGAVGGEGVQNYLCAAQAAAVLIGLAVTAAWPGGWWIDPAIALGIAAWSVREGIESWRGEDCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE1</accession>
    <name>A0A7K0JRE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21560" checksum="E691B1A3EAD38DC2" modified="2021-04-07" version="1">MSESPYQKRRILRLSKDQTQRADARENRRRLVEAARSAFASGESVALEDIAARADVGIGTLYRHFPKREALVAAVYHDQIEDLRAGADALLAWHAPLEALRRWMDLFAEWATAKRGMVETLAAMRRSGALDFDASRGEIEGILATLLAAGRDAGVLRADADPADVRSLLAGALAVAEDPTQAGRLFDLVLDAVKAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ6</accession>
    <name>A0A7K0JRJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS110 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000242">
        <property type="protein sequence ID" value="MST32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="43327" checksum="C4493D6FB87DE948" modified="2021-04-07" version="1">MFVGHDWAEDHHDIQINDETGRRLSRARLPEGVEGVARFHALVGEHAEDPAEVVVVSETDRGLFVGALVAAGYEVYAVNPMSVARYRERHATSGAKSDPGDAATMAELGRTDRHHHRRIAADSEGAEALKVLARAHQNLVWLRQRQANQLRSTLREFYPAALGLGELHGFDALGVLAVAPTPERGRLLSRSKIAAAIGRAGRQRHLDARAGELQAVLRAEQLAAPAAVSEAMGASVTAVVAVISTLNTQIARLEEQLEEGFDSHPDAKIVRSLPGLGTILGARVLAEFGDAPGRYADAKSRKNYAGTSPVTRASGKSRVVLARHVRNRRLGDACYLWAFAALSSSPGARAFYDAQRAANRTHNQALRALANRLVGVLHGCLTHATLYDEHTAWAHRLQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW9</accession>
    <name>A0A7K0JRW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000354">
        <property type="protein sequence ID" value="MST32663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="183"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="439" mass="47125" checksum="051DAB4A0C1C5EDE" modified="2021-04-07" version="1">MPGGRGEVDLRSLLGAVEEAFPIDVVDVLAGQLARSVDARHAALLIANFSGSALARLSHVECSGRGQDGRNERAESLSLRGTDHERVLFTQQPAVIARSHDWLVLVPVTERGDAIGVLEVSFGEEPATEAVGHLVAGAHALAYVLIASRRHTDLFEWAQRDIPFSISAEIQRRLLPSAYSLEAGPLTLAGWLEPSHDAGGDTFDYSLDREHLYLSVTDAMGHSVDASLLATLAVATLRNRRRALAPPAELADAAGEALRVHAEPDQFVTGLLMRVRLADGSAEVVNAGHPAPFLVRNGAVVPLDVTVQPPLGITDTAYRADQVVLAPGDRLLVITDGYLDRDARRVDVEAILASTTDRHPRQVVQELARRLLEVTGGELRDDATSLCIDWYGPTGVRSATGGASPARATNEPDRSRWEEEPASAPMLVDELPVPGDDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX0</accession>
    <name>A0A7K0JRX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000362">
        <property type="protein sequence ID" value="MST32685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="439" mass="46816" checksum="DD15085B6F119FDF" modified="2021-04-07" version="1" fragment="single">MRPVQPSSPYAQDRRDEGLSGPLPILPDYWMQRDRLHQQLPATPRQRLTLVTGPAGSGKTLLVAGWARSAAPGSRRWISLPRHREVSPSFWSDLLGDVGWEALTRGSDPEAGALLVIDNVETLACRETGAGLLDLLAAVPTAVRIVLVGRHAAALPLIDVSLDEAVAEIGGADLDFTAGEVVELYRMLGRPPSADVARAAMEQTGGWALGLRLAGVPTLRAPGGSAGLPAGDLGLLTEFFEREALAGQPQDVRELLEKVAVAPRLTVDVAEAISGRPDAGGVLERLAAENRFVRRDGEGRFALHRLFATVLVHLLAGQGAGSVVAARRRAAAALLDAHEEEASARQLVAARDYDDALAIRLRALRQRLEWQPGGSLEPALPGGMPDHFLCADPWRMYATCVALLVGEDLDEAAVWLVRLEVAAALPGAPAGMVQRAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX8</accession>
    <name>A0A7K0JRX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000358">
        <property type="protein sequence ID" value="MST32677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="15969" checksum="53920E30BDC18A0A" modified="2021-04-07" version="1">MDIPGPVLSGGGAEGVARPRVLIAKTSLDGHWRGVNVVSRALRDAGFEVLLAGMATAATIARIAADEDVDLIGLNVGGRVEVVERILDVLAEQGVEAAVFAGGTLPPYAVRRLEARGVRCFPPGSTLEAIVAAARDLTGWSPAPGTGAGLGPRGVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS06</accession>
    <name>A0A7K0JS06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ORF">GHK86_08230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000366">
        <property type="protein sequence ID" value="MST32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="22973" checksum="B9A37E883D559C06" modified="2021-04-07" version="1">MSGAAASPGAAGGRFIVLEGGEASGKSTQAARLAERLGALLTREPGGTPLGERIRSLLLDPAPSPDPSAPGGAGGLAPRTEALLLLAARAEHVAAVIRPALEAGADVVCDRFAGSTLAYQGWGRGLPVAELRSLSEWAAAGCEPDLVVLLQVPPEVGAARLAARGRAADRMEGAGASFFERVEEGFAALAAADPDRWAVVDGDGTVDAVADRVAAAVAERLAARAPGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS19</accession>
    <name>A0A7K0JS19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_08425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000378">
        <property type="protein sequence ID" value="MST32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="311" mass="34387" checksum="ADADCCEDB15D579F" modified="2021-04-07" version="1">MAKTTSDSGEQDLVRLYLDGIGKYPLLTKDDEVTLAKAIEAGRTAEAELAKPGRLPAAKTRELRRAVRAGDVATEAFVNANLRLVVSIAKKYQSADMPLLDLIQEGNLGLIHAVEKFDWRKGFKFSTYATWWIRQAIGRGIDNSSRTIRLPVHAGDQIRRLLRVRGQMEGELGRLPTAAELSEVMQMPEEQVTELLQYGAEPVSLETPIGSEGDTELADIVADLSAPTPFDLVAQGMLSSEIDKLLAPLDEREKQILRLRYGLDRGDPRTLEEVGSALNLTRERIRQIERTALSKLRHPSADNGAHDLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS43</accession>
    <name>A0A7K0JS43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA-acylating methylmalonate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mmsA</name>
        <name evidence="5" type="ORF">GHK86_06575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000282">
        <property type="protein sequence ID" value="MST32384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="19"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="495" mass="51480" checksum="68BD777CC6BC2886" modified="2021-04-07" version="1">MQRISHWIGGQRVAGRSGRSGPVFDPATGQQTGAVDLADVGEVDEAVASAVAASRDWRRASLAKRAAVLFAFRELLHARQDDLAAVVTAEHGKVLADAAGEVARGLENVEFATGVPHLLKGGYSEQASTGVDVYSIRQPLGVVAGITPFNFPVMVPLWMCANAIACGNAFVLKPSEKDPSASLLLAELWQEAGLPDGVFTVVHGDKTAVDRLIDHPDVAALSFVGSTPVARAIYEAGTARGKRVQALGGAKNHMVVLPDADVDLAADAAVSAGYGAAGERCMAISVVVPVGAVADPLIDAIAARIGKLRVGAGTEPGTDMGPLITAEHRDRVAGYLDAGAGAGATVVVDGRQATLPASGFFLGASLVDRVEPSMSVYRDEIFGPVLSVVRRDSYDEALALVNANPFANGTAIFTRDGGAARAFQTDVEVGMVGINVPIPVPVAAYSFGGWKASLFGDTHMYGPEGLNFYTRGKVVTSRWPDPASSSVDLGFPRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS68</accession>
    <name>A0A7K0JS68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000387">
        <property type="protein sequence ID" value="MST32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="25487" checksum="59BF492E36F3551C" modified="2021-04-07" version="1">MNDLTLAPADFEPKMLVPAYFHPVERPQLWAAMADNPDKVGIVILNVANGPGHERDGVWLEAVEPLLSAGIDVVGYVDTGYGRRPRHEVVADIGCHLLWYQVTGILFDQVATAPEHVETVGSLARHARDLGARLVVFNHGAYPAEGYAEHADILGTFEGSWGAYVDLSVPVWTRRLPERKAYHVVHSVPLGHFADAALLARSRRAGYVYLTDRDGPNPYDRLPAVPPTAWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS96</accession>
    <name>A0A7K0JS96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000401">
        <property type="protein sequence ID" value="MST32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="45"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20104" checksum="03F22B46EDA7F40A" modified="2021-04-07" version="1" fragment="single">MAWLGGPDAAAGVALDVAGDGTLAAVTAGVERPPEGATVLRGLTLPGLVNAHSHAFHRGLRGWTQGDGGTFWTWRERMYGLARRLDPDRYLALATAAYAEMALAGITTVGEFHYLHHDPDGRPYATDAMGEAIVEAAARAGIRLTLLDTCYLWGGIGTQPDPVQRRFSDGVGGAGAFFLLLDDPEVYGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS98</accession>
    <name>A0A7K0JS98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000391">
        <property type="protein sequence ID" value="MST32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="450"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="551" mass="59300" checksum="6B0B02A25A179059" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB3</accession>
    <name>A0A7K0JSB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gatC</name>
        <name evidence="2" type="ORF">GHK86_08910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000404">
        <property type="protein sequence ID" value="MST32838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="11066" checksum="C5842CBBCFB5D7C8" modified="2021-04-07" version="1">MAVMADRITAGDVAHVARLARLQLTDDELDRYTGQLAAVLDHARDIEALDLAGVPPTAHPLPLENVLREDVARPGIDRAEVLAAAPSVEGDRFRVPRILGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD3</accession>
    <name>A0A7K0JSD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR04076 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000304">
        <property type="protein sequence ID" value="MST32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="11897" checksum="0630224A73080AD9" modified="2021-04-07" version="1">MAGDETVVWDLRVTVERVEGRPVCGLAPGDWFEVVGSSRLQLPEGRHFCIYALAAVLPLLPAKQRTLPAGDWLERDTLVACPDPDERLVMRIERTQRRVLATDDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE1</accession>
    <name>A0A7K0JSE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="484" mass="53032" checksum="C0D379F5FCFD68D1" modified="2021-04-07" version="1">MRAEALDEPELEFGGASRHIDPRFGICSYGPADLAVPGAPRAIRVGLVGPSASLDGLRNWLERCRDPIPAKDERYPHLFPAFPGFDTDRSLHSTLVFSDRNTRGLSSQVLRRMVGPDKAEALELAVAAYADEVSALAEGNRVDVILIARPDELTDTGTTVRRQRRAVRSSSAGTSAAAMPLGPQTANFHDVLKARVLHLGPPIQIIRRGTWDETVATSAGRRRQDEATRAWNLHVAMYYKAGGVPWRLPRATTDLTVCFIGVSFYRNVYGTAIETSVAQVFNERGDGVIVRGGPASINSDDKQPHLSAADAHGLLNEALEAYRREHRTLPARVVLHKSSRFTEPELDGFQRAADGRGVDALELVWIVGSEPAHLFRPGAAPPLRGTLLTLEDHAAALYTKGSVQFYSTYPGMYVPQPIGIRPAMTDRSIREIAAELLALSKMNWNQTQLDGRLPVTLRTANQVKAILRFASFEPATSTTYAHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH9</accession>
    <name>A0A7K0JSH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000319">
        <property type="protein sequence ID" value="MST32524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="12546" checksum="336E676C73D9794E" modified="2021-04-07" version="1" fragment="single">MALSGATRVAAVIGDPVEHSLSPALHNAAFAAAGLDWVYVAFPVPAGQGTGAVRAVRTLGLGGLSVTMPHKRDAAGAVDRLTPAAAALGAVNTVIPTPSGLLGDSTDGDGLLDALRADPGFDPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP2</accession>
    <name>A0A7K0JSP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000338">
        <property type="protein sequence ID" value="MST32594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="19675" checksum="3DA54D97D8F83AD2" modified="2021-04-07" version="1" fragment="single">MPDPVRTRAHLLGDGLALGTFVALGLPDGMLGTAWPSMHHSLRAPVGDLGLVLLASTAGSVAVAAFVGSLLRRAPVGSLLAAGLGCAAGAAVGFSLAPAFGVLVGVAVLFGVSAGVVDGGLNTVVGLSGRRRLLNLLHGAYGVGTSIGPLIVTAAIVSGSWRPAYLVLLGVDVALGGSWLLHRRSATGRQPASPAPVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR0</accession>
    <name>A0A7K0JSR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5,6-dimethylbenzimidazole synthase</fullName>
            <ecNumber evidence="3">1.13.11.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bluB</name>
        <name evidence="3" type="ORF">GHK86_09625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.79" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="572" mass="60099" checksum="43BDEC8FC02C574F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS6</accession>
    <name>A0A7K0JSS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000347">
        <property type="protein sequence ID" value="MST32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="8855" checksum="EA961B7BF8464902" modified="2021-04-07" version="1" fragment="single">MTQEAGRVERCAPPLAGIDRGEGPVVVLLHGQPGTSADWSAVVPLLADRFRVLAPDRPGYGRTAGPAAGFAGNAEAVLAHLDRAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU1</accession>
    <name>A0A7K0JSU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000449">
        <property type="protein sequence ID" value="MST32997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="PTHR10363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6720" checksum="15EB9BD8B656F860" modified="2021-04-07" version="1">SWGKDRGKDGFYTMNDSWFDEYVFEIAARRDLLPPELQAALDQPPIVLPAWDPMGALAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT28</accession>
    <name>A0A7K0JT28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription termination/antitermination protein NusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nusA</name>
        <name evidence="9" type="ORF">GHK86_10185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000477">
        <property type="protein sequence ID" value="MST33087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="394" mass="42862" checksum="8B3931B7BBE70306" modified="2021-04-07" version="1" fragment="single">MKDQFAFLDALQQIAKDKGISVDTLLDALANALVAAYKRLPDAAEEAVVTIDPETGDIRVYGQELDEDGNVVREWDDTPSDFGRIAAQTAKQVMTQRIREAERDLKYEEYAGREGDIVTGIIQQSDNRYTLLDLGKVEALLPQAEQVPYERYEHGARLKAYIVEVRKTTKGPQIVVSRTHPGLIKRLFELEVPEISSGVVEIKAAAREPGHRTKIAVWSNDGNVDPVGACVGARGARVRMVTNELRGEKVDIVPFSDDPREFVMRALQPAKVKEVHLDDLTGTATVVVHDFQLSLAIGKEGQNARLAARLTGWRIDIKSETQMAEEEAYANEDWAEGEWVTNAEGEMVWQPAEGGEAVSAEAWSLGEGGTPEDGEGGGEAASAAEPAPADGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT32</accession>
    <name>A0A7K0JT32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heme lyase CcmF/NrfE family subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_10200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000479">
        <property type="protein sequence ID" value="MST33090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003568">
        <property type="entry name" value="Cyt_c_biogenesis_CcmF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01411">
        <property type="entry name" value="CCMFBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="90"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="CcmF_C" evidence="9">
        <location>
            <begin position="317"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="468" mass="50409" checksum="DA273AADC94912C8" modified="2021-04-07" version="1" fragment="single">MLDSAVGQSAVIVALVAALAGAATLLRGLRTGRSELLRMGRSYVWVILLGAVVATAAMQHALITHDFRLVYVGQNDSLQTPLLYRVTAMWSALQGSILLWALILSLYLAAVAFHFRRRALDPLVGWASLVGYLIAAFFFGLMATASNPFVTTAHPVLNGPGPDPLLQNRVLVAFHPPMLYLGMVGFTVPFCFAIGSLVTGRVGEGWMVETRRWTLFAWMFLSGGLVLGAWWSYEVLGWGGYWAWDPVENAALLPWLTATAYLHSVMVQERRGMLRVWNLSLVLATFSLTVLCTFLTRSGVLASVHSFSNSDIGPELLTFFAVVVATAVGLLAWRGDRLRSPGAIDSPLSREGAFLANNLLFGAFAVVVLLGTVFPLIVQAVNGSQITVGGPYFNTMTLPIVICLLFLMAVAPVLPWRKASAELLRHRLLWPAVAAAVTLVACVAGGLRGLLPLLAFTLGAFAGASALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH0</accession>
    <name>A0A7K0JTH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17351" checksum="87F0CB2D6D5B192A" modified="2021-04-07" version="1">MSRHHYGALASVIVGWIVCRVVAVPLVRLAGDIGGHTRGGDVAVGVVVAAVPFAVLVVYSLIRLTNRSGLLRLPSVRGLLWFGWFAAGGVMGLLPYSEMGAELSLRTREAHAAPGFLHGMDMTILAGLFLVVALLLIALRARPDHTTGPVAWLEHQVEDEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ6</accession>
    <name>A0A7K0JTJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000409">
        <property type="protein sequence ID" value="MST32849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029524225" evidence="2">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="55" mass="5695" checksum="E1C09FA9673C14FC" modified="2021-04-07" version="1">MLLALLTAVNLYSPAAANDSHAAEATAIVAAIMIGFVLVVAGMASVGRRPRQRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR8</accession>
    <name>A0A7K0JTR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000566">
        <property type="protein sequence ID" value="MST33341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="16563" checksum="A53F2D3B94D533C8" modified="2021-04-07" version="1" fragment="single">MVFAALLLGVAVEVLAFVAVADQIHVLPALGLLLVVSALGPLVVKRVGLGVLANARTRLAAGEEPTRELLDGLLVLGGGVLLCIPGFVGDAIGLLLMVGPVRHVVIRLAGHRVAQGARVVRFDRGGVVDASTHDRPAPGRDGGEPPARFIGRPGAASESDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS8</accession>
    <name>A0A7K0JTS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThuA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000567">
        <property type="protein sequence ID" value="MST33345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="231" mass="25088" checksum="865ECFE365484643" modified="2021-04-07" version="1">MTVRNLILSGGVNHPCRETSARLAELLAEVGIESEVTEDLDAAMAGLASAPVDLVTVNALRWRMGAERYAPQRDEWALHLSSAARTGMLAHLRRAGGLLGIHTASICFDDWPEWGRILGGAWDWDRSSHPPLGEARVSVAPGGDPLVSGLGDFATVDEIYGFLRTEPDVEGLLVATHGGVAHPVLWRRHFGAARVVYDALGHDLRGYEPSTQREVIRRAGRWAATGEWSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT6</accession>
    <name>A0A7K0JTT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpaF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000570">
        <property type="protein sequence ID" value="MST33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="80"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="379" mass="41602" checksum="E25FB6FE83409893" modified="2021-04-07" version="1" fragment="single">MHEPAWESPLEAIERAVQERAKDRALDVGASGARDELRRLIDDEVERWHADYQRGRRGFDLAEPARTAERALRNLLGYGPLQPLLEDPDVWEIEVNAPDAIFVRRHRGESGYHDEVFHDDDHVLRVLTKILDDAGRSHRKLDPAEGLQDAQLDTGARLHIVHSDIGRDGHVLVNIRKFTGLRLRTLGELVELDMLDRAVADFLRAAVRAGLSVLVAGPPGSGKTTLLSCLTAELNPALRVVIAEEVFETDCGLPNVAHMQTRPARSDRPAVDLRRLVAGFLRMAPDVAIVGEVRDREALPLLLTLSSGVQGFTTIHAGSARQALSRLRFVAALADNRELTLAALSSLVAEAVDVVVHCCRLDGVPQVTEVVAVEDLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX4</accession>
    <name>A0A7K0JTX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="18961" checksum="453A6283391D4506" modified="2021-04-07" version="1">MSFSPVRLNHAVLFVTDLERSERFYHQVFGMEVIAREPRANAAFLRLPRSGNHHDLGLFGIGPAGPKRRGVGLYHLAWQVDTIEELAAARDELMAAGAYTGESSHGATKSVYGADPDGNEFEIMWMLPREAWGDYEHAAPIDHLDLPGELRRWSGMRTAGSFVPGGEEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX7</accession>
    <name>A0A7K0JTX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000579">
        <property type="protein sequence ID" value="MST33390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_M" evidence="3">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="141"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="39608" checksum="A8A0C54682EF2E07" modified="2021-04-07" version="1">RGGGGVREVALSPLDAPRPTEIAVLPETVAKDVKVALLRRADEAARAAGAAVRQVSASYGDSRRRILVANSDGVLATDDQVRTRFAISCVAEGDTGLQTGRESIGATVGFELFDTKDVDELARRAAARAIAKLAARPAPAGTLPVVIKQGSGGILFHEACGHGLEADHIVKDLSVFAHRVGERVASPLVTLVDDGTMGPEWGAFAIDDEGHPAGRNVLIEDGVLTDYMWDWLRARKEGRASSGNGRRETYQHLPMVRMTNTFLANGTEDPDEIVRQTPHGVYVAQLGGGQVNTATGDFTFGATEVYLIEDGEITEPLRDTNLIGNGPEILRLIDVVGNDFAMGSPGTCGKQGQGVPVGTGQPTLRVSALTVGGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU24</accession>
    <name>A0A7K0JU24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000584">
        <property type="protein sequence ID" value="MST33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5307" checksum="E6EB5B9EE94F4C4D" modified="2021-04-07" version="1" fragment="single">MTPPADDPFERATNLAWEVAGDAAVVVDAEAGTAHALTPTAADVFRALGTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU71</accession>
    <name>A0A7K0JU71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_12200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000610">
        <property type="protein sequence ID" value="MST33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="30809" checksum="E27A6F05C3EAA7A3" modified="2021-04-07" version="1">MWKGLKRQWKYQSAKINNKLEERADPKIQLEQAIQEAQEQHRMLVEQAANVIARQKQTELQLNRAMDDLAKTNQSTRQALVLAQQAQASGDAAKAAQYNQAAEGFANQLVAIEQRVQDLKQISLQTAQASDQAKAAVQQNSTRLQQQLAERNNLLNQLEQARMQEQLNAATSQLSQTVGGDVPSLDQVREKIESRYAKAVGTSELGNATVESRMLEVQQAVIGVQAQSKLDQIRAQMQLEAGGDTGGAGARTGATLEAGASGELPEGSPGTPDAAQPIEDAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM3</accession>
    <name>A0A7K0JUM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_13125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000677">
        <property type="protein sequence ID" value="MST33656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="26929" checksum="C3BB2A76E84310CC" modified="2021-04-07" version="1">QPGRRLAPGTPLFAGGPDPVAEVGERLGDGMRAVRLLPAPGQALEALLAGIGTVPLPPYIHTALADPDRYQTVYAERPGSVAAPTAGLHLTDEVLARCRDRGVAVASVDLAVGLGTFRPVTAERVEDHEMHEERYHVPEATLVACAAAQRVVAVGTTVVRALETAAATGRTSGRSDLFIRPGHTWRAVDALLTNFHQPRSTLLLLVEAFVGPRWRDLYALALAEGYRFLSFGDAMLLAGGRGGGRSSGGRSSDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR7</accession>
    <name>A0A7K0JUR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxogl_dehyd_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000534">
        <property type="protein sequence ID" value="MST33249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxogl_dehyd_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="8273" checksum="9257712A5EF0ADC0" modified="2021-04-07" version="1" fragment="single">MPEDPPTRELFGPNAWLVDDMYEQYRRDPESVSPSWREFFEGYRPGGVNLARPSLSLPAEAAGAPAPALPAAGAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV4</accession>
    <name>A0A7K0JUV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP</name>
        <name evidence="3" type="ORF">GHK86_13545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000704">
        <property type="protein sequence ID" value="MST33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="27219" checksum="F53FF8DFE5F6F8EB" modified="2021-04-07" version="1" fragment="single">MSLVMGVLNVTPDSFSDGGRWLDHDRAIAHGLRLAAEGADVVDVGGESTRPGAAPVAEDEERRRVLPVIAALAPHVRVSVDTRKVAVAEAAVAAGATIVNDVSATLWPVAASAGVGWVAMHLPADPAVMADYAARYRGDIVADVVTHLVARAEAARDAGVGEIWIDPGIGFGKTAAHNLLLLRHLDRLVATGWPVAVGTSRKRFLGPLSSLPGEEPAAPADRVEASVATATWAVLQGAAMVRVHDVAPTVWAVRLAAGAPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW9</accession>
    <name>A0A7K0JUW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000708">
        <property type="protein sequence ID" value="MST33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14353" checksum="ABC5A5234E0970F1" modified="2021-04-07" version="1">MRAVTGRAVALDAADVRLPTGGGDAVAAAAEAFLGLPYLWGGASGWGVDCSGLAWLCHRRCGRRIPRDAHDQAASGVAVGRAELRPGDLVFFARPGQPVHHVGVALGPDEMIHAPGTGGPVERAGIDAPGRGAMAGARRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV23</accession>
    <name>A0A7K0JV23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000569">
        <property type="protein sequence ID" value="MST33349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000470">
        <property type="entry name" value="CbxX/CfqX_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00820">
        <property type="entry name" value="CBXXCFQX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_6" evidence="2">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="22264" checksum="BC2D1A8942FBC2A4" modified="2021-04-07" version="1">AVTRDDLVGQYVGHTAPKTKEVLKRAMGGVLFIDEAYYLYRVENERDYGQESIEILLQVMENQREDLVVILAGYKDRMDTFFSANPGMSSRIAHHIDFPDYAVDELAAIGELMLRDSGYELSPEARAVFTDYLRRRREQPRFANARSVRNALERSRLRHAKRVLASGRPLDREALVRLEPEDFLGSRVFADPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV49</accession>
    <name>A0A7K0JV49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000741">
        <property type="protein sequence ID" value="MST33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="41"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="366" mass="41624" checksum="D89C444135AD6E61" modified="2021-04-07" version="1">MLDISEELGAGIDAGYTLPADWYLGEEVLREEQKLIFERTWQYVGRTDQLREPGDYLTATVGHVPVVVVRHHDGGLRGFVNVCRHRCAEVVLEAGHRNVLQCHYHAWAYDLDGALISAPRSDREPDFDPAAFGLLPVAVDSWDPFVFVHVGPDPVPFRDYVGDLPERMRADGIDLANLEFRQHGEWEVAANWKVVVENFDECYHCPVAHPSFTRVMEVDPVGYHLEEGAWWSRAVTGIRRSAREPGANLPYPLAGPLERGQFGFVWPNFTVVQNPGPDNLMAFWFVPDGPERTRVVMDYWFGREVTDEAAQQIIDFNVVVGAEDQRLVESVQRGLRSGRVRQGRLLLDSERLIQHFHRLVHRSLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV75</accession>
    <name>A0A7K0JV75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000580">
        <property type="protein sequence ID" value="MST33399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="494" mass="51502" checksum="304388DCB9304A19" modified="2021-04-07" version="1">MSESVPIVDVTSSSGQLARGSLRTSDAIAISVSVLAPGMAMALNTGGVASVAGGSTPLSFVLGGVACLTLGFVVIGFTRRMAVAGYAYTYASRSLGKQVGFLAGWMYAFGMAAFVPMTMAGVGYLAASLLGLDPGYWILFFLIGMALLMTLSIVRINVTTKLQIGVAVVTVAILVILDLVITAKGGAHGQSLQPFTFSKTASGGFHGVFYGIIFGVTSYIGFETAADFGEETANPRRAVPIAVIVSVVFAIVFYVWTTYAATIGFGVNALKHNPSGWVDNGLIPVATRYIGTWFGKLIDIGALLAAFIVSVACATASSRTLFAMGREGVAPAWMGRTHAKYKTPVNATAVVATVSVVLALVIGYGFASANTGGPALTIYYFWATVGTLAIILVYITICIGGIVFFKRTSPRFNPLTHVLIPLVGAVIFGAAWYGSVYPVPAAPINATPYLTAAWLVIGIVVLVWLNRTRPGSVARIGSILGEEGGELVEALDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA4</accession>
    <name>A0A7K0JVA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000756">
        <property type="protein sequence ID" value="MST33871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15298" checksum="F4FC6F51D6E5DBF0" modified="2021-04-07" version="1">MLDLAAAGTALVLLVLAPLFPPSSLWATPAVLLVVAGQLLTVRERRYVSFRHLPLLARREQLIARVAFTFFAGLGLLLLAAAGVLTVHTDNGPACTAGATVCHVFNHAFHDMVVAWFGCIFTGHAAVLVNRYRRLGSSPLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD8</accession>
    <name>A0A7K0JVD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhzF family phenazine biosynthesis isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000606">
        <property type="protein sequence ID" value="MST33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="277" mass="29381" checksum="BC506FA9EA73115F" modified="2021-04-07" version="1">MRTFTQVDVFTDRLGLGNAVAVVHDATGLTDDALARFARWTQLSETTFLLPPTDPDADYRLRIFTASSELPFAGHPTLGSARAWLEAGGRPRRPDRLVQECGAGLVELRRSGDRLAFRAPPRLRSGPVAPGEVARLTAGLGLRPDQVVDARWADNGPGWVALLLDSAAAVLGIEPRLDLLRPDEMIGVVGPHPDGSAARFEVRAFFAGRGLEEDPVTGSLNAALAQWLIPAGLAPSSYVAAQGTCLQREGRVHVEADGPDVWVGGDTVVGVTGTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF7</accession>
    <name>A0A7K0JVF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000779">
        <property type="protein sequence ID" value="MST33936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="49"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="31077" checksum="9C6CD23DFB37268D" modified="2021-04-07" version="1" fragment="single">MVNVPTVREAAEQLWQGQGDLVGSDHPLAGFGQGRAEELDDGILYLKSLSSVTALDSGAGLVLLDTGGQYDTDTVFDAVRRWRPATRLAAAVYSHHHVDHVFGTARFDAEAAAAGWAPPTVYGHADLPDHFRRYRRTAGWNTAINVRQFGLPVDGFAWPVEYRFPDVTYRDALTVRVGELTFELHHARGETDDATWTWVPERRLVHAGDLFIWAVPNAGNPQKVQRYLGDWAAALRAIAARRPEVLVSGHGLPIFGAERIATALADTAELLDFIETRTLALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU8</accession>
    <name>A0A7K0JVU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000840">
        <property type="protein sequence ID" value="MST34080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="24205" checksum="16CC401164188F42" modified="2021-04-07" version="1">PRMDETAAPEAAAAGANRRALVVDDHALFAEALARVLTTQGFACQVASLLDVEGEIHAFRPHLVLLDVNLGGVDGLELVPPAVRAGAKVVIVTGTRDDDRLAVAAALGASGWVDKSSALPELVDVATAVLAGRPLWDAARHADLVERGRRELARQADLRWRFDGLTSREWEVLERLDLGHSVPAIGAELHISVPTVRSHIRGILAKLDVPSQLAAVALYNERRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ9</accession>
    <name>A0A7K0JVZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000697">
        <property type="protein sequence ID" value="MST33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="8836" checksum="17492F5034EC5958" modified="2021-04-07" version="1">MPRSMDWGPPRTYDLADPTDRRILYERVLREASGSEELCAWIHGPSLAALWAKLWLPRRVRDAWEDRFPELRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW50</accession>
    <name>A0A7K0JW50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000724">
        <property type="protein sequence ID" value="MST33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="454" mass="50145" checksum="2EC5C787194A5EFD" modified="2021-04-07" version="1">MTDPESRPESRPAAPDPSKPEPPILDPSIRRGFNEPRLSRRQLLRMAGLGAGALGAGAILEACGVSGAKVQSTADAGKTGVGSASWWAKQDLHHVVNFANWPYYIDVVNGKHLSLEHFTAMTGIKVNYSEPIDNNVPFYEKIRPSLTAKQYTGFDLIVMTNNSPPLGYLIEYGWLTPLDHSMMVNFEKYAGPLVKNPSWDPGNKFTMAWQSGWTAIGYNSSVIPSPGSSVEVLFDKKYAGRVGMMSDPQELGSVGLLAIGVEPATSTESDWKKAAKKLQQQKSDGIVRAYYDQSYIDHLKNGDIVVSQAWSGDIFQADLNSKYRNLKFLMPNEGGMFWTDNMCIPAYSQNPKDAMTLMDYFYDPGTQAVVEYYNDYVCPVPAARQVLLHPSGWAATALKEMAPSIGLPTSVTANAPTVFPDQQYTQLSRNYYSYKSQDELTAWNNLFLPIIQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW67</accession>
    <name>A0A7K0JW67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000726">
        <property type="protein sequence ID" value="MST33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20172" checksum="D5A8030E190D6272" modified="2021-04-07" version="1" fragment="single">MDPVNDDATGVAEAGNGTRPRPPGSDIELVDAFVAASRALVAVAARSLAGMGEDITLPQYRALVVLASRGPQRAADLAASLDVTPSTASRMIERLVRKRLVGRARTKEDRRTLRVYLTRSGRDIVAAVTDRRREEITRILGEMPDEGRVPLASALRAFAAAAGEVPEQDWALGWDAAGTDGELADDGPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD0</accession>
    <name>A0A7K0JWD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000752">
        <property type="protein sequence ID" value="MST33864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="7882" checksum="1151FDADDC42432F" modified="2021-04-07" version="1">MGRQGGQLPEGYGLWRILRWLMVAVVGYMALLVLVPQRPTFSFVYMLVVIGALIAFFVRVQRRRRQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE0</accession>
    <name>A0A7K0JWE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000917">
        <property type="protein sequence ID" value="MST34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="22942" checksum="9009DD94201B6A0B" modified="2021-04-07" version="1">MTGRFLTQPRSRTRSRLRPWYQKRPYQLAVAAVVVATAVVTDRYDRYDPVQQQHRLTSLASTVRSDLQFCRDGVALVERRWAALPADATVAQRRQVGTIASDAEPSCTPVGQDGGVYSLASLQPPRGLPHTNELTQALYDATEWAYPSAARYLLAVETLARNPGDAGAELQATDAQQSMRSFRSEADALVAKVAHGLAMHKAPSLGLPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF5</accession>
    <name>A0A7K0JWF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000926">
        <property type="protein sequence ID" value="MST34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="27254" checksum="875244CA75D0EF30" modified="2021-04-07" version="1">AARLGRPEQGKAAIFPTCLVEYQAPDVGQDLVKVYERNGVSCSLVDGAGCCGAPFLHAGDFDGFLAQARRNVPALAAAVRAGKDVVVPQPTCGYVLKRDYPEYVDTAEARLVGEHTFDASEYLWRLHKGEGTELDTEFAGQVPATTAYHVPCHLQAQNIGLRSRDLLKLTGTKVTVVNKCSGIDGMWGLRADNYELSRKVAQPLKAALEKADAEVVAGDCHLANGAIVQEAGRAPRHPLQQLARAYGIEEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK6</accession>
    <name>A0A7K0JWK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiaminase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000783">
        <property type="protein sequence ID" value="MST33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="234" mass="25213" checksum="76028F6597AE8207" modified="2021-04-07" version="1">MSAAPTPGFCERAWSATAGLQEQLVHHPFNEALAAGTLAPARFAYYLVQDSRYLKDFSVALAEAGRRSDVAAEAEFFAGSAQRALGVERALHAGYLSRLLGPGDAERVRTSAACGAYTAFLARAAAHQPYPVLVAALVPCFWVYRHVGQRILARTAAQADHPYRAWIDTYADAAFAAAVDQVKAIADRRAREAADQVPAMLAAFTAATRHERSFWDAAWSASLSDLPDPPYGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM5</accession>
    <name>A0A7K0JWM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid racemase</fullName>
            <ecNumber evidence="2">5.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000785">
        <property type="protein sequence ID" value="MST33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="25926" checksum="92905CCC473F46F8" modified="2021-04-07" version="1">MTTGTGLAERIGIVACSAEGAALCYRTFCAEAAAILGPYAHPDVCLHGRSLACYVELLDQGDWEGVAGLMLSSAEALARAGADLLVCPDNTIHQALPLLRHRSPLPWLHIADVVADEATRRGYTRLGILGTQWLMEGSVYSTVLGSRGVSAVIPQLDDRGAIHTVIMDELVHGLVRQESLQRCQDAVLRLSDLGCEAVVLGCTELPLLLNDANTPLPTLDSTRLLARAAAVATCGLPHHVPPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN5</accession>
    <name>A0A7K0JWN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate, phosphate dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000797">
        <property type="protein sequence ID" value="MST33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="11411" checksum="659D1B2F902A051B" modified="2021-04-07" version="1">GDAVVLVRPEATTEDIAALAECRGLLTGTGARTSHAAVVARQLDIVCLVACRELAFDAGGGIRLGGVEVAEGDWLTLDGDGGRVYAGRLPVVEERPDELIRRVRGWAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP3</accession>
    <name>A0A7K0JWP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000796">
        <property type="protein sequence ID" value="MST33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="13388" checksum="2203E67F233F6FB9" modified="2021-04-07" version="1">SLLAWSGYFLAAKRASRRCEPLEYTAGATLVGGIAAAVLVVATGTVPVLHAGAWLWIGLLAVVPGTAHLLMNWAHHRVDAGLSSVLVSINPIVASAAGWVVLGQRLGVVQIVGALVTLVAVSLVARPDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ7</accession>
    <name>A0A7K0JWQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_14905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000806">
        <property type="protein sequence ID" value="MST34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="11">
        <location>
            <begin position="95"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="10">
        <location>
            <begin position="458"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="567" mass="61377" checksum="E30D90B751200EF9" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV2</accession>
    <name>A0A7K0JWV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S Mo/W bis-MGD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000995">
        <property type="protein sequence ID" value="MST34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="19875" checksum="1FC05DA6FEAFCD02" modified="2021-04-07" version="1" fragment="single">MRNPISHWPVVRQLREGDLYGRGIAAKSGTSASLAPRTVTADKVVKSVCPYCGVGCAQNVYVKDDKIVHVEGDPDSPVSRGRLCPKGANTLELSTSPARRYHVLHRRPHGTDWERMPLDEALDMVAERVIATRREHWDAEFKGKTVNRTMGIASLGGATLDNGGGTEVLAAVLGRLRPAGVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW7</accession>
    <name>A0A7K0JWW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Patatin-like phospholipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001009">
        <property type="protein sequence ID" value="MST34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="11550" checksum="0E39F8240A0D57D4" modified="2021-04-07" version="1" fragment="single">MRVGVALGAGGAVGVAFHGGVLAALQEATGWDPRDAEVLVGTSAGSLSASLLRLGLTTADLRAVSEGQPLSDVGQLIAGPGGPHRPRTDLRAFLRPRPPASVAAVARGLLDPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX8</accession>
    <name>A0A7K0JWX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="5">SHMT</shortName>
            <shortName evidence="5">Serine methylase</shortName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glyA</name>
        <name evidence="8" type="ORF">GHK86_17215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001015">
        <property type="protein sequence ID" value="MST34453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="7">
        <location>
            <begin position="6"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="350"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="412" mass="43865" checksum="6CA4D91DC09CB140" modified="2021-04-07" version="1">MSSVADDPELFGLIERELERQNTTLQLIASENFTSRAVMAATGSVLTNKYSEGYPGKRYYGGNQVVDDVEDLARRRVCELFGAEHANVQPHSGSNANLAVYLATLDAGDTVLGLRLDQGGHLTHGSPVNISGRYYDFVSYGVTDSDERIDVDELRRLAEQHRPKLIVAGATAYPRVIDPAPIREVADAVGARFLFDAAHVAGLIAGGVHPNPTGVADVVTFTTHKTLRGPRGGCILSGGELAAAIDKAVFPGLQGGPLDHVVAGKAVAFHEALQPEFKAYAAQIVRNARALAAALAGHGLRIVSGGTDTHLLLVDLRRFDADLTGKKAQESLDRAGITCNKNTIPGDPRSPFVTSGLRLGTPAVTTTGMREAEMEQIAELIARVLRRPDDAGELAAVRDLVASLCSKFTPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ1</accession>
    <name>A0A7K0JWZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001020">
        <property type="protein sequence ID" value="MST34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="114"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="487" mass="54152" checksum="8525FED08EFB0A3A" modified="2021-04-07" version="1">EGLEGDVTMTTELVIRCSYGEAVPWVVQSGRGLSAVAGPDGLCLDTPVTLQGRDHRSVGTFRVARGEQVTFCLGWHASHEHPPSPIDPAAALEETAAFWEQWCDRVRRVHGPWEDAVLRSLITLKALTYAPTGGIVAAATTSLPEDLGGVRNWDYRYCWVRDASLTLDALVEAGCREEAERWMAWLVRAAAGAPDQLQIMYGPAGERRLTEFEVDHLPGYEGSQPVRVGNAASEQFQLDVYGELMDATDRARRHGIAEPPEAWALQRAVMDFVSAHWRDPDDGIWEVRGPRRHFTHSKVMAWVAFDRAVRAVERYGKDGPVDEWRRARDEVHAEVLEHGWSETRGAFTQYYGGDALDASILMLPIVGFLPPDDRRVVSTVEAVERELLADGFVRRYQNDSGVDGLPGQEGAFLPCSFWLADCLALIGRLDDARSLFERLVGLANDLGLLSEEYDHRFERLVGNFPQAFSHVGLVNTARNLAARDSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX70</accession>
    <name>A0A7K0JX70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001065">
        <property type="protein sequence ID" value="MST34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14315" checksum="70212AC277389F45" modified="2021-04-07" version="1" fragment="single">MTQCHDPYEPKDWGSGLHVVRDRSPEAAGCHDPYAMDFALPEWAQGGHGCEVREVRRGEVCILRLTGRLDWMTASEFAAFVCSECADPGVVIDLTDAEVDAAGTGALLKTAADRRRHHRQLVVVVADGPGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC2</accession>
    <name>A0A7K0JXC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GHMP_kinases_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000892">
        <property type="protein sequence ID" value="MST34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="251" mass="24968" checksum="75885EBDF51BF352" modified="2021-04-07" version="1" fragment="single">MDCSSRSLSVAVSRAGGPLGDLGSPVPTSSVRTGRRLPAVFAPVVGARGPSAPPRPPHVLRCGVGAVEVGAFTGLGACAPERCAAGAPRPAGAPTWPRSGPLRRQAGALRHCRSPHFDPNPSYRLARPPRPSPPVPARATAGAGEGAEGARETPALASAAMRARAPGSAANLGPGFDALALALDLHVVVDVEPAERLAVTATGHGADLPQDAGHLAAQVAVAVAGTDRLAIHVHSDIPVGRGLGSSAALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH8</accession>
    <name>A0A7K0JXH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000912">
        <property type="protein sequence ID" value="MST34244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029666989" evidence="1">
        <location>
            <begin position="38"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="15721" checksum="37BEBCAA9E38E21C" modified="2021-04-07" version="1">YLSVRAALPALLEASGAVVLVSSVAALAAPPASVAYAVSKAGLLALGRSLAVDHGADGLRANVVCPGWTRSEMADREMDALAARDGDGRERAYDQATQLVPLRRPATAAEVGEVIAWLLSPAAGYVTGAVLTVDGGLTAVDPGGVAFGHHLRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI7</accession>
    <name>A0A7K0JXI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001143">
        <property type="protein sequence ID" value="MST34675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="145"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="368" mass="39712" checksum="4979E2C4BC66BB11" modified="2021-04-07" version="1">MARSSDAVDAVDTRVYTIPTDHPEGDGTLAWDSTTLVVVTVRAGETTGLGWTYTSAAAKDLIDDKLAGTVQGTDPLDVVGTHETMVRAVRNTGRPGLVSCAISAVDTALWDLKARLLGVALADLWGRGRADVPLYGSGGFTTYDDDTTRRQVEGWLGAGMSRVKIKIGESWGSEPQRDLHRARLVRRLVGDDVQVFVDANGAYTRKQAVRMGLRLAEEAGVVWFEEPVSSDDRTGLREVRDQCPQDVAAGEYGYLPHYFAELVTDEAVDCVQADVTRCGGYTDWLRVAGLVACHGLPISGHCAPNLHAHVAVHCPHLAHLEYFHDHVRIEQMLFDGALSPRGGALVPGSDPGHGMALKTADAEPYRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX4</accession>
    <name>A0A7K0JXX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001225">
        <property type="protein sequence ID" value="MST34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="13455" checksum="6591641746D2E2B5" modified="2021-04-07" version="1">MLPIREWPVPEIRVDEMVDGGELVIRAELPGVDPDKDVELTVHDGALDIRAERREEKETEEKGYLRRELRFGSFSRSLPLPQGVAEEDIKATYKNGILEVRVPHREPQEAKKIAVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY01</accession>
    <name>A0A7K0JY01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001232">
        <property type="protein sequence ID" value="MST34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="180" mass="18699" checksum="6927806F091E16B9" modified="2021-04-07" version="1" fragment="single">MKVRADTLTARIATGFALMTLTALALFAAGALVLIDADLNAAAHRQETTSTAAIAGALRRAYREDRRWTAADLAPSVALARAYGVDLRVSTGSGTILSVTARSADGPVRSFDVTEGGRVVARVRLQQPASGLSPADATLRRALSRSVLVTGLVATALAVVAGVLLARRLARPLERLRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY29</accession>
    <name>A0A7K0JY29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001254">
        <property type="protein sequence ID" value="MST34850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="61"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="412" mass="42992" checksum="64408367EDC9E14E" modified="2021-04-07" version="1">MTPAPEIVLRNCRVWDGVVETPIADAEVVVRDGRILACGPAASGDRSLRPGAVDVDLHGATVLAGLVNMHTHLSLSLPGPGGDAVAGLSPHALALHMADQATRTLRAGVTTVRCVAEKDHAEFALREAIAAGWVPGPRIFTAGRALACTGGHGHGSTDTLECDGADGFRRGARAQIRAGADLIKVMISGGIAGEHEAIDTPQLTSAEMAAAIETAHAWGRKVTAHAGPAPVIEEAVRLGLDCVEHGYQLTPAVARLMAERGTSLVPTLVVTRCREFFDRLGVPAWMQQRSLGAGERHAASYQMALEAGVEVMLGSDMPPAEPFEGTTATVRELEHMVALGLSPRAALAAATAVPARWLGAGDELGTVEPGKWADLIAVDGDPTADVSALRRLWWVMKGGVVVRDDRRAAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY39</accession>
    <name>A0A7K0JY39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001261">
        <property type="protein sequence ID" value="MST34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="323" mass="34027" checksum="E7B7AD2D5047FC17" modified="2021-04-07" version="1">GQAVLDPDVRLDVPLGRLRATGGDPRALVRLRSTLRDLAPDVVVAHGGEPLKYLAPLADGRFALVYYAIGTVTAAARSGRRAELYRWLLKRCDAVAGVSAETLEEATAVFGVRPDREVLLPNGRDPSLFHPAAREGEDGAAPVALAFVGHLTATKRPGWFLDLVGRLRAGGRDVRGVLIGDGPLEGALRAAAPSGVELLGRRADVPDLLRAADVLIFPSEPESEGMPGVLIEAGLTGLPVVATRVAGAATVVAHGRTGFVVPHDDFEALVAHATRLVDDRQLRREMGAAAREHCVARFSQDAVLDGWRTLLSSLAPLPGGMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY43</accession>
    <name>A0A7K0JY43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein</fullName>
            <shortName evidence="2">P2TMN nickel insertion protein</shortName>
            <ecNumber evidence="2">4.99.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nickel-pincer cofactor biosynthesis protein LarC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">larC</name>
        <name evidence="4" type="ORF">GHK86_19430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide</text>
            <dbReference type="Rhea" id="RHEA:54784"/>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <dbReference type="ChEBI" id="CHEBI:137372"/>
            <dbReference type="ChEBI" id="CHEBI:137373"/>
            <dbReference type="EC" id="4.99.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LarC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001276">
        <property type="protein sequence ID" value="MST34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="454" mass="47027" checksum="EFE72CF5D8910622" modified="2021-04-07" version="1">GDGAAGDAGELRRRPGGGGGGQRLRGRARRGPEPGGRGKATGRGRRRGTGGAAVRGGTAVSRRVAWWHCFSGIAGDMALGSLVDAGADLAAVERELAALPVGGWSLEARPVQRGGLAATEVVVQVRDTAVVRTHAHIVGLITEARLPDRARRRALAAFAALAEAEGRLHGRPPAQVHFHEVGGTDAIVDIVGTCVALEILGVDEVRASAVAQGSGMVRSAHGLLPVPAPAVLELLAGAPTYGTDVPFELTTPTGAALLAALAEGFGPMPALRVERVGRGAGSRELSGRPNVVQVVVGTAAEEEAAGHPVVLLETNLDDVTGEVLAHTLAALLDAGALDAWVTPVVGKKGRPAHQVSVLADPERAASLRALLVAETGTLGVRGRRLERWTAAREQAEVEVEGYRVRVKRSPAGVKAEHDDAARVARLLHRPLRDVARQAEATAGQESRPQLEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY76</accession>
    <name>A0A7K0JY76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ORF">GHK86_17345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="WJHE01001026">
        <property type="protein sequence ID" value="MST34479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="224" mass="23790" checksum="434BE0C7998B5007" modified="2021-04-07" version="1">MLGVHGELTVVDDLPGAFARTVIEAWQARTGELFHFALCGGSTAGPCYERLAAESENVIDWLSVDVYWGDERCVPGDDPDSNQHLGRQALLERVGGANAVYPMSCDEGPDAYALRLGEVGKLDVIHLGMGPDGHTASLFPGSEALDADPGQLVARNVDPSGRNKLPRMTLTFSAIARARLVVFTVAGAAKRDTLRAVIDGADLPAGRVTADRVVWLVDRDAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL1</accession>
    <name>A0A7K0JYL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="10" type="ORF">GHK86_20225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001382">
        <property type="protein sequence ID" value="MST35043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST35043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="396" mass="43595" checksum="65A297B46048FF69" modified="2021-04-07" version="1">MSKQKFERTKPHLNIGTMGHVDHGKTTLTAAITKVLSERDPAGNAAVAFDQIDKAPEERQRGITINIAHVEYQTPNRHYAHVDMPGHADYIKNMITGAAQVDGAILVVSAADGPMAQTREHVLLARQVGVPSIVVALNKSDAVDDEELLDLVELEVRELLNEYEFPGDDTPVVRVSALKALEGDKAWEDKIIELMEAVDSFVPEPQRDLDKPFLMPIEDVMTIPGRGTVVTGKVEQGKIKVGEEVEIVGLRNTQKTTVTGVEMFHKLLDQGQAGDNIGALLRGTKKDEVERGQVLCKPGSITPHTDFEAQIYVLSKDEGGRHKPFFNNYRPQFYFRTTDVTGSIKLPEGTEMVMPGDNTAITVELQKPIAMEEGLRFAIREGGRTVASGRVTKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL9</accession>
    <name>A0A7K0JYL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Circadian clock protein KaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001388">
        <property type="protein sequence ID" value="MST35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02978">
        <property type="entry name" value="KaiB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039022">
        <property type="entry name" value="KaiB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011649">
        <property type="entry name" value="KaiB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41709">
        <property type="entry name" value="PTHR41709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07689">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01248">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="11158" checksum="C16C6EE9C737F7D0" modified="2021-04-07" version="1">MSAADAATDGPWHLRLYIAGRTARSEAALHNLRQICEEHLAGMYSIEVVDLLERPQLAQGEQIVAIPTLERRLPPPVRKIIGDLSNTERVLIGLDLLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM7</accession>
    <name>A0A7K0JYM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_20335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001396">
        <property type="protein sequence ID" value="MST35065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_51K" evidence="8">
        <location>
            <begin position="45"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="9">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST35065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="274" mass="27791" checksum="7ED76C8D72DDF37D" modified="2021-04-07" version="1" fragment="single">RPTGAADPTALPRLLQGAPLRSPADHLRVWGPLPQPRRAQLLAEVEAAGLTGRGGAGFPLAAKLAAASHGPAGTVVVNATEGEPVSAKDATLLAASPHLVLDGAAAAAHATGAAAVVVCLKRSHADLARQVEEVVGLRRRAGLDRVRIQVTTAPDRYVAGQETALVRWLNGGEARPTTVPPRPTSRGVGRRPTLVSNAETLAHLALITRFGAAWFRSLGRPDAPGTTLATVSGDLRAPGVYEVPLGVPLGDLIAAAGGDPAANGGVLVGGYFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN4</accession>
    <name>A0A7K0JYN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001400">
        <property type="protein sequence ID" value="MST35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13145" checksum="15FCAADBEBB33AAA" modified="2021-04-07" version="1" fragment="single">MVTKPGRQGRPTGRPSVVGPALARHPFLAVGAWWVWAMTEVSVVLFVVYRHSFTPWGAVAAQVIAYAVLVAPVLLLRSPVQAPVSSSRWWLSVGLGGVVLVAAIAVVASAHAPGFTARQVVKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN7</accession>
    <name>A0A7K0JYN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_20385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001411">
        <property type="protein sequence ID" value="MST35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="101"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="33779" checksum="50FC73B62DA0E5D3" modified="2021-04-07" version="1" fragment="single">RAVAVGARLAPLADVLLALTLAVVLAVGAAQVHAHRLSVGGLVVFLTYLGALQQPVRALSTLSRTLGQGQASRERLDELLAAPELPDPAGGRILGHRPPVIALHHVGFRYADGRVALDDVSGWMPAGRMTALLGPNGAGKSTLLHLLARLDDPAGGVVTLDGVDARAYDLRSLRSRVALVPQDGWLLDGTLTDNIAYGTPGATDEAVRAAGEAALVDEFADRLPEGWATPLGEGGHALSAGQRRRVALARAVLQDRPVLLLDEPTTGLDADAQRLVIEAIRVVAAGRTTVVVTHEPALAALADHVVTLRAGRVAPAAGAAGAAELAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB7</accession>
    <name>A0A7K0JZB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001550">
        <property type="protein sequence ID" value="MST35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="49"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="15974" checksum="88C7A8DF60EBCDF0" modified="2021-04-07" version="1" fragment="single">MTEQATLVLRGGRVRTPGGFAEALAATGERITAVGTDDEVAELIGPSTRVVELRGRLAIPAFGDAHIHAISGGVESLRCDLTGLRTRPEYLERIATHVAGLAPDAWVLGGGWSMEAFPGGVPTAADLDAVCGGRPVFLPNRDHHSAWVNTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZS7</accession>
    <name>A0A7K0JZS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001691">
        <property type="protein sequence ID" value="MST35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="16157" checksum="82B6163A445BAF26" modified="2021-04-07" version="1" fragment="single">MPSTHPKPRSHEVTDGFERAPARAMLRAVGMTDDDWGKPQIGVASSWNEVTPCNLPLDRLAKRAKEGVREAGGFPLEFVTIAVSDGISMGHEGMRASLVSREVIADSVETMMHAERFDALLTFAGCDKSLPGMLMAAARLNVPAVFLYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMG3</accession>
    <name>A0A7K0JMG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_00160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000005">
        <property type="protein sequence ID" value="MST31143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="290" mass="30923" checksum="348EACF62DA217E1" modified="2021-04-07" version="1">PRLRAELDARGDFAVHARVAPDQTSAEADIAHGRVVVVVVVGADGRPARVLIDGSNLLTATTAQRELTVLQKAAPTSGPPLGVRVLYNPSFNSTTFMIPGLIGIIMTQVGLVLTALGVVRERERGTIEQLMITPVRKLELIVGKTVPYLLIGLGDFLVVLLVAWALFGVPVRGSVPLLFGEALLFLVATLGMGLLISTVARTQLQAMQMSVFVQLPQMLLSGLIFPLAAMPWGVRWISYALPLTYFVSVSRGVLLKGVGPGELVPETVALSVLAVAYVGLAAVRFRKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMN4</accession>
    <name>A0A7K0JMN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilM</name>
        <name evidence="3" type="ORF">GHK86_00370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01175">
        <property type="entry name" value="pilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="565" mass="57740" checksum="CABC84D5F12821F2" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX2</accession>
    <name>A0A7K0JMX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000031">
        <property type="protein sequence ID" value="MST31288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029807443" description="RCK N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="322" mass="33168" checksum="4F1B9004EA28C6B5" modified="2021-04-07" version="1">MPSILALLVSRLTRSQAARLVAVGAVCLLGGAGAFAVTQHLSFGTGVYWAITTATTVGYGDVTPKDTAGRVIASLVMLTTIPLFASAFALFAGAVAAAHVRRLLAVVRAEPTGGEVVVYGDAPVVPQVAATLAGAGRRVIVVSRDQPSGLPQDVRHLAADPTSEGAVRRSHPDRASSLLVTGASDADVLVTAVLLRQAAPGVPTVALARSASVCRALRELGVPVQVSADEVVVQTLAKSLEAPHAGEILLRLMDSDGYRMRELPAGPDDVGQPLGQVRGRHRGLVLGLVRADHVSIGVIEDPVVEAGDQLLVVEPLSPSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN03</accession>
    <name>A0A7K0JN03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000038">
        <property type="protein sequence ID" value="MST31335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="353" mass="35196" checksum="BEA966727D435813" modified="2021-04-07" version="1">MLADTWLLESTPQGDNWVPVTTPVHPAASQGATAVSTGSETLLVGGQQGTGSSAALSGATWAWNGRTWSMLPTRTAPPARSAGVVADDEALGGVVAFSGTGVHGLLDDVWILRGDRWLRLATSPPPAARSGAVGVYDAASRQILVFGGATTGNRAVGGTVVLAALPPVAVSSPTTTASTSTTTTSGTGSTTARSTPGSTASHHRTGSASASSSTTVTTTPVVSKGATPTRIRGGDVVTLDGGGFAPGARVVVTFEPTHRVVAVTRADASGNFRVEVTVPDGASAGRHDFRATGAGRHGPIALVTPVQVAAYTTPAHVSPATTASLVGLAVAVPVLTLLGLQLAGRTRRHPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN97</accession>
    <name>A0A7K0JN97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="159"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="381" mass="42240" checksum="D3B65F53AE5D568E" modified="2021-04-07" version="1">MTIQPWAATSGGGARIVRVDTVPVRAPLAREFRGSYYRMSNRATLVVQVHTDAGVTGEVYVGDEDETLLTIESIVQREIAPRLIDRDVLATERCWEAAHPVTFDILRDRRLGLVALAGVDAAIWDAVGKILDQPLWRLWGGYRRSVPMVAIGGYYGEPLGPLAEEVAHYRELGLAGMKLKVGGASPEEDARRVSVAREAGGADFVLTLDANQGYSARDALELCRRVDGLGVRWFEEPVRWENDRRGLRDIRLMTALPVCAGQSEHSAAGCRDLMEAGAIDVCNFDSSWSGGPTAWRRVAALAHTYGVEMGHHEEPHVAAHLLASQPHGTYVECFHPDRDPFWWNLVTNRPPLEGGFLTLSDRPGFGWDLDWDYIGHHRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT6</accession>
    <name>A0A7K0JNT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9755" checksum="EADF16C1EE31E7F4" modified="2021-04-07" version="1">MLAVASEPGPLLFIVDHAHWLDRSSARILAFMARRLVAEPVGVLFATRDPGGDKRERSQRSPAVHSDRRRWSQPGSVPSHRGPNPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY7</accession>
    <name>A0A7K0JNY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_02395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000100">
        <property type="protein sequence ID" value="MST31581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="342" mass="37619" checksum="D29CB847017D7DF5" modified="2021-04-07" version="1">MRSPDGEVLLRAREVVKDFPVRANVGGRKKGVVHAVHSVSLELRSGETLGVVGESGCGKSTLARLVTRLLPLTSGTVEFEGRDITKLSRRGLRPIRREMQLIFQDPYASLNPRRRVGDIVAEPLRVHRLADGAAARRRVQELFEVVRLDPSHVDRYPHEFSGGQRQRIGIARALALQPKLVVADEPVSALDVSIQAQVLGLMADLQQEFGLTYLFIAHDLAVVYHVSDRIAVMYLGDLVELGPADPLYQAPLHPYTEALLSAAPELDDGTGAARPRIVLTGDVPNPIDRPSGCSFHTRCPHAQDRCRVEQPELREIEPGRFAACHFPRPAPTPRPQAQAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP19</accession>
    <name>A0A7K0JP19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit NuoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuoE</name>
        <name evidence="8" type="ORF">GHK86_03120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000124">
        <property type="protein sequence ID" value="MST31720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="239" mass="25189" checksum="B2F70355F8333A7A" modified="2021-04-07" version="1">MARLTPHNEQRARDLIAVYPHPRSALIPLLHLLQEQDGHLTADGMEHVGELVGLEAAEVRGTASFYDMFHTEPVGKYLVAVCTNIACLLQGAYELLEHAEERLGVAPGGTTPDGLFTLEDAECLALCGNAPCLTVNWRFFGDVDRERFDEIIRRLAAGELDGEVPPHGTLARVRRTVGVPAAGVSVHGAGGPDPEYVPAPPAESAEPGAPADGVADGVDLETHATTPAVASLDGPGEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP29</accession>
    <name>A0A7K0JP29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000036">
        <property type="protein sequence ID" value="MST31314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="758" mass="79685" checksum="1593D86E92644009" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP59</accession>
    <name>A0A7K0JP59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">kdpC</name>
        <name evidence="12" type="ORF">GHK86_03035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000119">
        <property type="protein sequence ID" value="MST31703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="20199" checksum="709F587EC432FF7E" modified="2021-04-07" version="1">MKALWSALRLVLVSTVVLGLGYNLLIVGVGQAAFRHQANGSLVRYHGKVVGSSLIEQQFTSARFFSGRPSATSPPYNAAASTGSNFGPTNPKLIQEIKGNLAAFLKANPGVKASQVPPDLVESSWSGLDPDISPAAAYLQVPRVAKANHLSVATVRSLVAQHTSGRFIGIYGDPIVNVLQLNLALLKATAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC9</accession>
    <name>A0A7K0JPC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_03285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="21880" checksum="E18A1F8A501AD6EF" modified="2021-04-07" version="1">MAVFTSYVTSVSASATLSEADLAAAAAEDLDGTFPEIVRRYGPALYTLAVRLCGQRADAEDLAAASFERAYRALRTQPARQTAALRFRPWLVTIALNQWRNQLRSRSRRPATAPLELGHDPPAAGADPAEHLPGDPAVACALAALPHPQRLAVLLRHVAGLSTSEVALALDCRPGTAKSHISRGLTALRAALEAPSPPTPNPEPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD7</accession>
    <name>A0A7K0JPD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANTAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000063">
        <property type="protein sequence ID" value="MST31414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="171"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="26195" checksum="BD23B51A1D85E676" modified="2021-04-07" version="1">MESLSGGFQRAAAFVATTSPLLVVDTELVIQDANPAYVAVMGRTRAELIGAPIFDAFPDNPDDPDGRGSRQLEASFEAVFRTARRNRRPLHRYDIPAPHGRGFARKHWIVTNSPLRSQDGRVIGALHHPEDMTAVAELLAAPPEPGSAAPSTDEQLWRSLVATLAFEADGHRQAQRGVRELQRALESRVVIEQAKGVIAARNQIDVEEAFRRLRRHARDNNAGIHQVAQAVIDSRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF0</accession>
    <name>A0A7K0JPF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000064">
        <property type="protein sequence ID" value="MST31424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="19343" checksum="1BFA07B85A00C965" modified="2021-04-07" version="1">MVRSPQTLSEVDRRLVAGWAADCAERVLRLFEAEVPDDERPRMLIARARAFARGELNTAEEIRRRFAGGVGANEVKAPAAVAAARSAGQAVGVCHMGAHALGAAGYAALAAGLAAPERPEAVQDEVRWQVAHMSEEVRDALRTLPLIGKNRSGPLGPGLLASGRLGRIIRELQTDLARPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH2</accession>
    <name>A0A7K0JPH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mycofactocin radical SAM maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mftC</name>
        <name evidence="8" type="ORF">GHK86_03535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034480">
        <property type="entry name" value="Heme_carboxy_lyase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023913">
        <property type="entry name" value="MftC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00316">
        <property type="entry name" value="C-terminal_tyrosine_decarboxyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01385">
        <property type="entry name" value="heme_carboxy_lyase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03962">
        <property type="entry name" value="mycofact_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="378" mass="41238" checksum="FF7F204D30830347" modified="2021-04-07" version="1" fragment="single">MIPVRADEPRPGGGRLVDQFEYGLDAPICLTWELTYACNLACVHCLSSSGRRDPRELSTAEAEQVVDDLQRMQVFYVNIGGGEPTVRADFWHLVDYMVDHRVGVKFSTNGVRLDRSRAAQLARSDYVDVQVSLDGATPEVNDRIRGDGSFATAIRALEHLAEAGVRGCKVSVVVTRDNVGQLDRFKALADRYGAQLRLTRLRPSGRGAEVWDRLHPLPDQQRELYDWLVAHGEGVLTGDSFFHLSAYGDALPGLNLCGAGRVVCLIDPIGDVYACPFAIHDEFRAGSVRDEGGFARVWRSSPLFASLRRPQAGGACTSCSEYDACRGGCMAAKFFTGLPVDGPDPECVRGFGEAALAARDGTPPPRSPVDHSRSRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN7</accession>
    <name>A0A7K0JPN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000176">
        <property type="protein sequence ID" value="MST31930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="130"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="34491" checksum="A8B5071EF1AA2B88" modified="2021-04-07" version="1">MPWPSSLIVAFIEANRDEFGVEPICAALQVAPSTYYAARRRQIAPSARAVRDVVMTQLLMALWVANRKVYGADKLWKAARRAGHDIGRDQVARLMRTAGMVGVTRRRKVFTTRADPDATRADDLVNRAFKAERPDALWVTDLTYVPTRSGMAYVCFIVDAFSRRIVGWRVAANMRTDMVLDALEMARRSRGGRRLVGLVAHSDAGSQFTSVRFTERLAEIGARPSIGTVADSYDNALAETTNGLYKAECVYGPDANGWDDVEHLELATLGWVHWFNETRLHGYCGDVPPAEFEAAFYAAQHTDHPVVGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS6</accession>
    <name>A0A7K0JPS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="6290" checksum="06F7086FCB082C24" modified="2021-04-07" version="1">MKLVRLGVVPHRMVGNRHRFNASDVLAFREREERRREEILAGMAPAEGCHTKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT5</accession>
    <name>A0A7K0JPT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">6-chlorohydroxyquinol-1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_04090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000172">
        <property type="protein sequence ID" value="MST31907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dioxygenase_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="7">
        <location>
            <begin position="105"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31685" checksum="367433D3C246444C" modified="2021-04-07" version="1">MADDRRPVGPGEITRAARASFAGAPDERQRFLLQRLVECLHGYASDVGLTRAEWEAAVAFLTETGQTCSERRQEFILLSDTLGLSMLVDALDHPSPTGATESTVLGPFHVAGAPLRPMGSSTVEQDGSGEPAWVTGTVRGTDGRPVAGALLDVWQNAANRLYAVQDAAQPPGNLRGRFRTGTDGTFAFWSVRPVDYPIPDDGPVGRLLAATGRHPWRPAHLHVMVSAPGYRPVATHFFDRASPYLDSDAVFGVKPSLVADFVPHAPAEPGAPPGWEGTWYSLEKDVVLAPLGDEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU7</accession>
    <name>A0A7K0JPU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="16" type="ORF">GHK86_04140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="WJHE01000174">
        <property type="protein sequence ID" value="MST31917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="13">
        <location>
            <begin position="25"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="141"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="14">
        <location>
            <begin position="404"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="15">
        <location>
            <begin position="482"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="627"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="1070"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1171"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST31917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1191" mass="132588" checksum="DBA04BBA9FBFAFBD" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX1</accession>
    <name>A0A7K0JPX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13230" checksum="52ED5A2DD44ECACF" modified="2021-04-07" version="1">MIPTLSSRDEAARRRAMNDPSAAAEQRQREDAAREAEHARQLAERDRLAAAEAAQRAAVMDAIRLVEGVVQAAERAATDAVTERRAAVAAGDFETALAVEQRRLAAVSLAGEARGQLRELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY3</accession>
    <name>A0A7K0JPY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_04600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="9">
        <location>
            <begin position="299"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="492" mass="53543" checksum="B0B7D42D7E1D34FF" modified="2021-04-07" version="1">MTSTELRPAALEPLSRHPERASGSTGIDHGHRLRLLPWALPFLLLADIAATVTATTVGLAASSALSPRALLPALVIDVPVALGFLTGYGLYRRARRRLVPSSFPDLSRLVHACLIGTTAAYILARVADRELGTARIPTEGAVIIAPAEIILLVVCRMVVRWAVTKRRSRVLVVGSGIVAGNILQRLTAIPYLEVVGYVDDNHGLEPHDSRPSARALGALQHVASIIEEHDVDHVLVAFSPVPESHVAALLRGLPGHVRISVVPRMFDLLSVRSSVDDLAGLPIIDVAPPELGLIDRTAKRSMDIVGSATALLLLAPVMIVIALLVRLTSPGPAIFRQQRTGRGGRPFHILKFRTMHVGSEGQRSRLITDNQGTGPLFKLHTDPRVTRLGRVLRATSLDELPQLVNVLKGDMSLVGPRPFIPLEARDIAGWAALRHTVRPGITGLWQICGRSDLPYDELRRLDYSYVASWSLGWDIRILWHTPASVLRRNGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ82</accession>
    <name>A0A7K0JQ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000125">
        <property type="protein sequence ID" value="MST31724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="274" mass="28697" checksum="0E6D8F645CFEAF29" modified="2021-04-07" version="1">MKIFVSSDMEGTAGVVDWDQVRPGSPAYPAFVELLLAEVNAAIEGAAEAGAGEFVVNDSHGRMANLPPDRLAGRARYLSGRLKPRYMMEGLDGSFDAVFLVSYHGSMSARASTLSHTYFPAAFAEVTLNGAVVGEAGINALVAQHYGVPVVLITGDETTAAEIGAVCPGIRAAVVKRSVTRFAAESLHPHAACELIREQARLAVADLAGAAPPAIALPATLGLRFHNTDYADLATRISGVARTGDLEAEITGADPLALFTTFITVVLLCRGFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD1</accession>
    <name>A0A7K0JQD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EthD family reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02118">
        <property type="entry name" value="TIGR02118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="10632" checksum="A1D60834EA6EDD0D" modified="2021-04-07" version="1">MVKLIVLYGHPTDPAAFDAHYSSTHADLVAKMPGVRRFEVAKCTSVDGSASPYYLQAELWFDDAAALQGCLASPEGRAAAADVPNFATGGATMLTGEVLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG9</accession>
    <name>A0A7K0JQG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000228">
        <property type="protein sequence ID" value="MST32163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029844163" evidence="1">
        <location>
            <begin position="34"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="20412" checksum="285C94103A13EE44" modified="2021-04-07" version="1">MRHPILAVLGVTAVLAVAAASGSAALIARPARAAELGPAPGMCSGRSDADLRIIAHANGGPGAVPKFILNLTTDSTGQPTGALIVYRGPRHLTVTDFCRAWQHLPGQPTGDCEEGYPPGAVTAHAVGLGSLDGRPVLVRADVRKLADGEKLFRLRYRAWPPGETAVAGDSGCEDATWTWIPGEEAWAPLDQLQVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH3</accession>
    <name>A0A7K0JQH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000241">
        <property type="protein sequence ID" value="MST32198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="12"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="507" mass="55778" checksum="B3B32DCB777847A5" modified="2021-04-07" version="1">MSSWPDQPVIWEVNTAAWLRELGGPAGGRRRLDDVSSAEWDALLPPGVDAVWLMGVWERSPAGIAIARGNAGLRSDFRAALGDVTDADIVGSPYCIRSYSVDPAFGGEEGLAAARAELARRGLRLLLDYVPNHVAPDHAWTTEHPELFVHGSSEDVGAHPEAYLEVGGAHLAHGRDPYFPPWPDVVQLNAFEPRLRQATASTLAAIGDRADGVRCDMAMLMMNAVFARTWGANAGPEPAADFWPEVLAQVRATHPGMVFVAEAYWDLEWDLQQQGFDFCYDKRLYDRLVHEDAGAVRAHLGADLGYQHRLVRFLENHDEPRAAAAMDKGRERAAAVVIATLPGATLWHQGQLAGRRVRLPVFLDRWPDEPVDPDLLAFHERLLAATEERKVRAGDWALLGVEGWPDNDSAHQLLSWSWGDATHRAVVVVNLSAQASQGRVALPWPDLEGRWWRLTDIVSPGTTFDREGGELAAAGLYVDLPPWGYNVFAVGEIPAFLMRPDPTHAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH7</accession>
    <name>A0A7K0JQH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000244">
        <property type="protein sequence ID" value="MST32205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="17563" checksum="5C6B958D7287E017" modified="2021-04-07" version="1">RDPARRLRGRLAAPVTVWTAGGGDGGGGGGTPAEPVGLTVSSVLVAEGAPPEVVGLLGPLSDFWDAARATKRFVLHVLGAGQADLAERFAGHYPGDPYEGLRVSASPAGPVLEDCDTRAACSLTGQLEVGHGLLVRATLDEITVGGELVDPLVHFRGRYLTIASRLAGGHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI0</accession>
    <name>A0A7K0JQI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_05600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000241">
        <property type="protein sequence ID" value="MST32200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="8">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="7">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="15384" checksum="20067318D0A914EE" modified="2021-04-07" version="1">MFVASSYPLLDVFWTTLWIMGFFLWIWLAVLCFTDIFRSRDMGGFHKAAWVIAIFVLPLVGVLVYLLVRGGKMQAHAEEAAAAQDEAARQYIKSVTGGNGNGSTGTADELTKLVRLRDSGALTPEEYDREKARILAGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN4</accession>
    <name>A0A7K0JQN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000253">
        <property type="protein sequence ID" value="MST32242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="28064" checksum="5BCF6B715916C50E" modified="2021-04-07" version="1">MRGFPAGEGEGADTGEWEIVESLGAPTVGGRFDVRRDGTPKVQGVELAVAVQEFMWHLTHDAIGNLGCGVGLHAGVVAGADGRAVLLPAPSGSGKTTLTAALVASGWEYLSDELGILDPSGVAVQPFARPLCLSRSAISLIPGLMDRIPVELDAEGCEKIQVRPDDLRDAAACRTAAAVGAVVFPRYESGAATTVEALSRVETLVELLPNTFGLAAAGQPAMDTLAALCRVAPGYRLVSGDLQQAASAVRAIVRGRAQEELPEQQGVAASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU7</accession>
    <name>A0A7K0JQU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crotonase/enoyl-CoA hydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="26516" checksum="12CED73B2F6118DB" modified="2021-04-07" version="1">MSVEVTVEDHLLVVTINRPEARNAVNDVVAQGIEAAIDRLEAEDDLWVGILTGVPPVFSAGADLKMINAGRAADLATARGGFAGITRRERSKPVIAAVDGPALAGGTEMVLACDLVVASESASFGIPEVKRSLVAAGGALFRLPARIPFNVAMEWALTGDAVDAATAYRFGLVNHLCPAGGALDAARELAARVTANAPVAVRESRRAMLEAAGGDEERGWDLSARAMAAAMGSEDFREGLTAFIEKRPPAWTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR80</accession>
    <name>A0A7K0JR80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="69"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="28607" checksum="535EA1CA2AC88E1D" modified="2021-04-07" version="1">MPAAGVLRGVGPLRQDDPVPIDTADSWDRYAAAYQEAARWPATVVHYGPDLPTEDDLRLLGDLKAKRVLDLGCGGGQNAVVMARAGATVIGVDLSVEQLAHARELAAEREVRVELRQGDLADLAYLRADSIDLAFAADAFGYVEDLGRVFRQVHRVLKVGAPLVFSLPHPSWYLVGGGTADPLTVRRSYFDRSAVVRSVGDAQLTEYPHHLAELLTGLVRASYRVDQVVEPEPPVGVPRSGLWDEAATRVPRMLIVRARKEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR87</accession>
    <name>A0A7K0JR87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14941" checksum="5656624A32F29EB4" modified="2021-04-07" version="1">MPKDIKGNAGRKPPEPSASRADIEEWIRRQMPDLQPILVLVDESIQATIPGLQYALKRKRPYYGLPELGWLIEVAAYDVSVNVVFHGGADFECPPPLGTTGRTRYVKLSTLEDAQRPELQGWIEEASRTPGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC0</accession>
    <name>A0A7K0JRC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000307">
        <property type="protein sequence ID" value="MST32480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="360" mass="37294" checksum="70FB62365A82B43C" modified="2021-04-07" version="1" fragment="single">MSRDDTASSPVPQPGPGVWVLTLPSEHRSVSVARRAVTRHLEQVGLDDIVAAAQLVVSELVANAVLHAGGDIRVEVERIPDGARVAVIDHSHVLPVSAAPSESSMTGRGLQLVQRMAAELGAVATADGKRVWADLVVGWEPQDDGDGNPLELWGEEWPDARPAEALVPVELGDVPTGVLLAAKAHVDNLLRECTLATAGADEGVAAGVPLQLAHRVAAAVGGFADARMAMKRQALAAARAQQPRVALRLALPPSRAAAAAAYVAAIEEADAYCEAARLLTLASPPTHRVLRRWYVSEVIAQLEAGGAGGPGPTRTFEEALLGEVERLATSTAAAERAGRLAAVTEALARAGSPEAVSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC2</accession>
    <name>A0A7K0JRC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_07090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000309">
        <property type="protein sequence ID" value="MST32485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="66"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="341"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="754" mass="78462" checksum="B14C216BB23BCA2B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH8</accession>
    <name>A0A7K0JRH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_05545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000236">
        <property type="protein sequence ID" value="MST32189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="111" mass="12083" checksum="2450D59AE92EF5A1" modified="2021-04-07" version="1" fragment="single">MATDLTPRFTLSLRGYDKDEVDEYLESLAAHATDSDGELVASRQRSRDLEAQVQRLSARVGELEDAIRGESPNTVRAIGERISLILGEAEAGAAETLEQAELRADQLLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL2</accession>
    <name>A0A7K0JRL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000336">
        <property type="protein sequence ID" value="MST32586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="269"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="397" mass="42584" checksum="AB4FBA57EF4F4EA4" modified="2021-04-07" version="1">MPDERVFAARLMRLGLADEHGAVIGRIEDVVIGPAFGSSAPRVLGFVAGVQRRRIFVSAGRAAAIGPAGITLRGGTVDLRHFQSRDGEILASALFGRSLGAEIVMDVALAPNDRGDWEVASVALGARRALYRRTRRVVDWKEARTLFDSGPVGAQLAALRDMNPTDIAATVHALPPGRRALIAQAVPDEQLADILEELPEDEQVRLLEDLDLARAADVVEEMEPDDAADLLAAMPPERRAQFLTALEPEDAAALSRLLRYDATTAGGLMTPEPIIVAPDVSVAEVLARLRDPDVPSAIAAQAFVCEPPTDTPTGRFLGMVGFQRLLREPPANPVAGCISDAGHVRPELGEREVAERLAAYNLIAVAVCDDAGRLVGAVTVDDVLDRVLPVGWRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM3</accession>
    <name>A0A7K0JRM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class I fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000331">
        <property type="protein sequence ID" value="MST32563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="37956" checksum="C58079180AF8AD71" modified="2021-04-07" version="1">MDLQELLGDEAEALLSHTCKGIAAEDLCLPGPHALDHVMEQSDRPVPVLRNLAQLYNTGRLAGTGYLSILPVDQGIEHSGAASFAKHPSYFDPAKLVELAIEGGCNAFATTFGVLGLIARRYAHRIPLIVKLNHNELLTYPNRFDQVMFGSAREAYDLGAAGVGATIYFGSDESTRQLQEVSEAFQEAHELGMFTVLWCYLRNDAFKKDGVDYSLSADLTGQANHLGVTIEADIIKQKMAENNGGYRALGYGRTDPLVYDELTTDHPIDLVRWQVVNCYAGRIPLINSGGESKGAGDLAQAVRTAVVNKRAGGAGLITGRKAFQRPLREGVEILHAVQDVYLDERVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ2</accession>
    <name>A0A7K0JRQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR01458 family HAD-type hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000338">
        <property type="protein sequence ID" value="MST32597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="27251" checksum="565956AA217A4A1A" modified="2021-04-07" version="1">MATPRAVLLDIDGVLTTSWKPIDGAAPAVARIRACGLDVAFVTNTTSLSRARIAELLEASGIPVRPDEVVTAARAAAAYLIQQHPGCSCLFLNAGSVGEDLDGVHVVGEGEWDADIVLTGGAGPSVGYTELNAAFRLLLRGAPLVAMQRNFSWRTAEGPQLDMGAFVTGLEQAANVRATVIGKPSPSFFAAVLAELGVTPAEAVMVGDDIDADVLGAQASGLGGVLVRTGKFRPEVLDRAASPPDHVIDSIADLPALLGLPEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU6</accession>
    <name>A0A7K0JRU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ORF">GHK86_08000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000354">
        <property type="protein sequence ID" value="MST32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="274"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="359" mass="37819" checksum="C82B546D409B1414" modified="2021-04-07" version="1">MGLSIGIVGLPNVGKSTLFNALTGNEALAANYPFATIDPNVGVVNVPDPRLERLAGLYHSERVVPATVTFVDIAGLVRGASTGEGLGNQFLAAIRETDAICQVVRAFADPDVIHVDGAVDPRADIETVNTELVLADIQTIDNRLTKLHREAKGKPELRRVVDAAEAARAVLDEGVPVSAAAGRLDLDALGELHLLTAKPFVYVFNIDEAELGDDARAKELAAVVAPASSVVVCAGIEAELAGMDPAEAAELLAGYGQAEPGLVQLVHVGFETLGLQTFLTAGPKEARAWTIRRGATAPEAAGVIHTDFQKGFIKAEVVSYDDLIELGSVPAVRAAGKARLEGKDYVMRDGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS13</accession>
    <name>A0A7K0JS13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="34181" checksum="1C22EFCD859F90C7" modified="2021-04-07" version="1">MIGDTVVRSDPPSPAARPGTLPRLPHWPHQDHPSRTAPGASRRRGSRTRRRGSSGPSGQRRRTAIGHTDRVTASLDGKVAVVTGASSGIGRAIALLFAQEGAQVVVADLHPSPREGGRPTCDAIADAGGVARFVGTDLADPAAIERLVSTVVDAHGSIDVLVNNAATFVGKPLLETSLEEWDRVFAVNLRAVFLLTKLVVGQMLGQPAHAGVRGRIVNISSQHGMLAAPGDVSYGTSKSGVVYITRQVAADYAGRGIICNAVAPGKIVTGTSPADHDDERLAWSRARTPFPRLGEPADVARAALFLAGDDATFISGVNLLVDGGWTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS22</accession>
    <name>A0A7K0JS22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="899"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="966" mass="104063" checksum="4B65E4CF53455EF7" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF0</accession>
    <name>A0A7K0JSF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000408">
        <property type="protein sequence ID" value="MST32847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="516" mass="54854" checksum="C412AB13B0B88D7B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK9</accession>
    <name>A0A7K0JSK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">GHK86_09430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000437">
        <property type="protein sequence ID" value="MST32936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="330" mass="35115" checksum="47B1277AF99AC91F" modified="2021-04-07" version="1">MARDLAIDLGTANTLVYSRGRGIVLNEPTVIALNSRTQDVLAMGRDAWQMIGRTPGYIVAVRPLRKGAITDFEITQRMIRLLLERAGVSRFNRPRVLICVPSAITEVERRAVEEAARGAGANGAYLIDQPMAAAIGAGLPVHEPLGNMIVDVGGGTSETAVISLGGIVALEAIRVGSFDIDAAIQTYVRREYGIAIGERTAEEIKVAIGSAWPLEEEIKAEVRGRDLMSGLPKTVILAPEEVRGAIEEQVGAIVDSVVKCLGAAPPELAQDLITQGIHLVGGGGMLRGLDRRLAEETALPVHLVDAPLECVVLGAGKCLEEFDAVKDLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL2</accession>
    <name>A0A7K0JSL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ORF">GHK86_09305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000429">
        <property type="protein sequence ID" value="MST32913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="425" mass="46752" checksum="9F2D047B66F998D4" modified="2021-04-07" version="1">MAKFGESSDLVKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNDIIEEELSESSEVHFDELPKPAEIFQFLNDYVVGQERAKKILSVAVYNHYKRVQAGGYADNDVELQKSNILLLGPTGCGKTFLAQTLARLLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNILFVCGGAFAGLDRIIESRLGRQGIGFRADIRRAEERGEGDLLAQVLPEDLLKFGLIPEFVGRLPVIGAVSNLDKRALVRILNEPKNALVKQYHRVFELDNVELVFTDDALEAVAEQALLRGTGARGLRAILEEVLLEVMYDLPSRNDIGQCVVDRSVVLERVNPTLVPRTAEPAKENRPRRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM1</accession>
    <name>A0A7K0JSM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_09365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000432">
        <property type="protein sequence ID" value="MST32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="137"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="248"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="387" mass="42874" checksum="05DE637A8A405503" modified="2021-04-07" version="1" fragment="single">MAVDFTFPAEVEDIRLRVRAFVEGTIAPAEARQRSERTGDERVDRRALVGLIGELRRRAREEGLWLPHMPPEWGGMGLGPTAMAAVSAEAARSPIGPYVLNCQAPDEGNQHTLLHWGTEEQRERYLRPLCEGTTRSCFAMTEPEVAGSDPTLLQTRAVLDGDEWVINGHKWFISGARRAGFAILVARTEDQPEVPQAATSAFLVDLPAAGWEIVRDVETLAGSHNHCEIRITDLRVPATSLLGGRGQGHLLGQARLGPARLAHCMRWIAQCETALDLMVGRSLERYAHGSLLADKQGVQWLIADSALELYQAKLMVLHAAYRLEHDLPWKTEVSMAKHFVANTLWRVVDRAIQVHGALGYSTDTPLADMLKQARWSRLADGADEVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST4</accession>
    <name>A0A7K0JST4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000456">
        <property type="protein sequence ID" value="MST33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="430" mass="44587" checksum="3708603AF90FFF6E" modified="2021-04-07" version="1">MTAFREGVPIGRAVLASPGGDGARAVVRPLGVTRYPGLEVVLLEHLAAAARRQGVAALLFATAGDDAPAAELLRVVGLRSAVHGAGDAAMVRLATDPTDAYLRALEEREVHAMSRWLLSLRRPEGIGPSAVVVPEARARAVLDTLRAAGVVDPVVVTAESAGDSRSALAALAGDERVEAIGLASAGPAPQARLAALSRHVGRTKTVVVVDGSGASEGVWAQPGVSRVRSNLELGRIFSRPSRLRRRHPAADAGWSGHLTEVDDLDLRAARGILRRAVAPDGTVRALSQEDVEGLLGAYGVDAGRPVSAAVAVESRPGIGLAATVTVGRAASATSRLLPLTEHDLRVLTTGVGPREARQHLEDVLRRTARMVDDQSEVAQVRLGPGRPPGIVIGPTRDGGDDPWVRRLPDAVGTVPGHGLTPPGDGAGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY9</accession>
    <name>A0A7K0JSY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000468">
        <property type="protein sequence ID" value="MST33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="17769" checksum="EB3AAFF1696FDC5F" modified="2021-04-07" version="1" fragment="single">MELTNDFRVSVPPAKAWEVLTDVERIAPMLPGAQLQEIEGDQFRGIIKVKVGPITAQYKGTASWLEQDEAAGRVVLKASGRDTRGQGNASATITCTMTPDGDGTKVGVTTDLTITGKVAQFGRGVLADVSGKLIGQFVDALEADLKGEGAGGGAGRTAQGRAAPHPPGRAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT10</accession>
    <name>A0A7K0JT10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000469">
        <property type="protein sequence ID" value="MST33053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="275"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="41461" checksum="F323A8AF4AB3A00D" modified="2021-04-07" version="1">MPTAVIVDAVRTAGGKRNGRLSGWHPADLAAETLKALVERNQLDPALVDDVIMGCVMQVGAQSINIARNAVLAASFPESVPATTVDRQCGSSQQSLHFAAQGVMAGAYDVAIAAGVEVMSLVPMGASAAVPNVGVPFGPRVQERYRSLGGLVPQGISAEMIADQWGLTREELDAFGARSQQLAARATAEGRFEREIVAVPARLRDRETGKLVESEELVATDDGIRPGTTVETLAALKPAFKPDGKVTAGNSSQITDGASAVLVMSEEKAVALGLTPRARFHAFALAGVDPVTMLSGPIPATSKVLERAKLTLDDIDLVEINEAFASVVLAWAKEHHPDMDKVNVNGGAIALGHPLGASGTKLAATLLNELERSGGRWGLLTMCEGGGLANATVIERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK4</accession>
    <name>A0A7K0JTK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF177 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000541">
        <property type="protein sequence ID" value="MST33276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="16355" checksum="E84A5882832085F4" modified="2021-04-07" version="1" fragment="single">MGASPWLVPVTALRRAVGTQHHECRSGRLGELRVADTVVPADAETTVDVELSVVVGGIEAEGTVRSTWVGSCRRCLRPVGGSIEAPVRELYRPGGGDDEETYALGTDQLDLEPLARDALLLAMPLAPLCREDCQGLCPTCGADLADGPCGCPTEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM7</accession>
    <name>A0A7K0JTM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 4">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ald</name>
        <name evidence="11" type="ORF">GHK86_11150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 4"/>
    <dbReference type="EMBL" id="WJHE01000540">
        <property type="protein sequence ID" value="MST33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="9">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="39176" checksum="440CCFA5B8A91B1D" modified="2021-04-07" version="1">MRIGVPTEVKNHEYRVACTPAGVHELVRNGHEVFVQRGAGIGSSITDEEFTAAGATLIDSADEVWGTAEMVLKVKEPVEEEYHRLRKDLILFTYLHLAASRPCTDALVGAGTTAIAYETVELPDHSLPLLAPMSEVAGRMAPQAGAHHLQRDGGGRGVLMGGVSGVYAAKVVVLGGGVSGMNAAAIALGMQAEVLVLDKNIAKLREADRIYQGHLQTVASNAYEVERACLDADLVIGAVLVPGAKAPTLVSDDLVSRMKPGSVLVDIAIDQGGCFESSRPTTHADPVYKVHDSVFYCVANMPGAVPHTSTFALTNVTLPYAVEIANLGWREALRRDACLAKGLNTHAGQITYASVGEAHGLESVPLESVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW7</accession>
    <name>A0A7K0JTW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000465">
        <property type="protein sequence ID" value="MST33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029611696" evidence="1">
        <location>
            <begin position="37"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="461" mass="49473" checksum="747254C828BDC0E2" modified="2021-04-07" version="1">MGRVHQRGGFGKLKMGAAAAAVAMLASACGATGAQGNASSGNSGGGGGGSTATGSGGQTIKLITWVNPPAVDAFKKIDAEFHKAYPKLNVDLQTAASITGPYATLLQTSVDSGSADIVTDYPPMKPLPLKPTKSNESTWQYWSTHNVFAPLDGQSFLSRYTSSALKAETYNGKVYGLVSGSYQEGVFYNKTTFAKYHLTPPTTYSQFLSELKTLKAHGVTPLFDALGNVGPVYLQFLYYDLIADDWYPSAPGGNLATDLENGTVKWTAPQFTTVMQQEKTIAKYLEPNFTGVPWEAMPGDFAKGDAAMLLDGSWDMAAVHSANPSAKVGFFPLPGSNTAANNQPYVADNLTFSVLKSSKHKAAAMKWLQFFSKPSIYAQYVAMTGISPSESSGRYAGFTASTMGSWFGKGINDGKLYPVLSPTDAYWDQPANWPKLQQDVINGSKTPKQVQQLYQQDWKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU53</accession>
    <name>A0A7K0JU53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000489">
        <property type="protein sequence ID" value="MST33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="11369" checksum="1D29F39634AEBB93" modified="2021-04-07" version="1">MTRRKIAPGPVGADVDLEQEDIRLPDGSRLTDERATEIAERALVRRRGRPSVTDDESHTPSLTVRVSTTTRAALEEIAASQGRRLADVSREAFEEYIQRHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU62</accession>
    <name>A0A7K0JU62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000492">
        <property type="protein sequence ID" value="MST33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="24127" checksum="D4E5602A7487AA73" modified="2021-04-07" version="1" fragment="single">MAFAHLLAAVRILAYNGAHNPHAEHLSVGADWAVFLVGAGMILAGAFGVILLRNPVHCALFLVITLFGIALEFINETADFLAAVQIIVYAGAIVILFLFVIMFLGVDRKERIAAEPFKGQRPLAFALGLAVLILMLVLTGVTTWTTGAHSLSGALIQGPGPNSGHEGDVARLGQTIYTRFLLPFEMTAALLVIAIVAAVVLARTRHRVAGELSEDEQAAVAQGRPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA3</accession>
    <name>A0A7K0JUA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000613">
        <property type="protein sequence ID" value="MST33493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="22734" checksum="FCEF5EF95865F9D9" modified="2021-04-07" version="1" fragment="single">MSSGLLVPTAARAQSVGSLRAQAAQLEAQIQQLGQQEAALSERYDGATYALSQTQARVAAARSALRQALAKAGHARGVLQTEALDAYVSGSGGSPALTPLKSADQSLLRAEYEQTLANNQTDAMDAYQAASLQASTAERLLHQQEKAQTADLRAIAGDKVKVQAAADQLQQLLGHDKGQIATLVAAQQAAQRRAQERAAQLRIQQQQAAARAAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC4</accession>
    <name>A0A7K0JUC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_12600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000636">
        <property type="protein sequence ID" value="MST33556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="81"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="28121" checksum="CDB70BFC94BFBF9E" modified="2021-04-07" version="1">MTWNPLATIAAVTDAPTGTQAVDRAARLLTEIVDRAEPVTFSELAASSGLAKSTTSRLLLALERNGLVARDEAGAYRAGELFARYGSRTGGLADLAIVARPHLERLGELTGETVNLGVEQSGGVQQIAQVDSPYVLGAANWVGRLVPLHCTALGKVLLAHGAAQLPPGRLERLTERTITSRSALDAELEEVRRRGWAVTDEELEPGLVAVAAPVSDDRGVVVAALSVTGPTARVTPGRVRELVAHCIDQAHALSETLGHRSRREGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF7</accession>
    <name>A0A7K0JUF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_12725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000646">
        <property type="protein sequence ID" value="MST33580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="21758" checksum="7B36D532C53621CA" modified="2021-04-07" version="1" fragment="single">MAVLVDLQGVGARTADRALFDGLSLTVATGDRLGIVGINGTGKSTLLRVVAGVGAPDGGTVRRGRGVSVAYLDQEPDLPAGTVAEAVGPGWEAEAALDRLGMAPHAASDVATLSGGQRKRVALAAVLAHPSDLLVLDEPTNHLDLAAVAWLEERLAVFRGGLVLVSHDRHLLDRVTTRMLELDRGRSYLHEGGYASYLDARAERAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ8</accession>
    <name>A0A7K0JUQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_13285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000691">
        <property type="protein sequence ID" value="MST33686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="457" mass="45694" checksum="A3FEB4558C2CBA8A" modified="2021-04-07" version="1">MSDTAAGELSSTRDGARSTTWPLVAICAGYFMVILDTTVVNVALPALSRGLHASTTGLQWIVDGYSLAFAALLLSGGALADRRGAKAVFCAGVAVFTLCSAVAGTAASAAMLIAARAAQGFGAALAVPASLSLLQATYTDQRARRHAFGIWGGIAGIAAGAGPVLGGALVSAFGWRSVFFVNVPVGVAGLLLAARALPSVARRPHGADPAGQAAACAALTGLTVALIDAGSAGWSAPVVLGGLAAFLVAGTVFIHLEHRTARPMLPLGMFASRQLSAATTIGLLLNLGFYGELFVITLYLQGHLGLSPLLAGIALLPQMAMAVVGSTASGIVMARTGPRLPMLAGLLVGAAGLFSLTAPGAHGPYVVLIVPFLAVGLGMSFTMPAATAAVMEAAPTERAGLASGTLNAARQVGGVLGVALLGTLVTKQRHFITGLHLDMAIAGAAFLLGAVLSLWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV33</accession>
    <name>A0A7K0JV33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000738">
        <property type="protein sequence ID" value="MST33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="4">
        <location>
            <begin position="107"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="5">
        <location>
            <begin position="434"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="528" mass="54208" checksum="FF25010460A1A186" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV46</accession>
    <name>A0A7K0JV46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="391"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="467" mass="49605" checksum="15C26ED94185B0C0" modified="2021-04-07" version="1">MDTAALLLEAASRFRTADVDRAHTIYLEAFAVALQADRMATDGGVARVASTVAAALPSGRPPDARELLLRGLSTAYTEGLAAAAPALRAALDAFRGADRDRSAVAAWAWLPGRIAGELWDEAAWDELSRRGVERLRDAGALATLPAALSVRAFILLYRGELAAVASLVDEIRVATEATGTDLAPYAALVLAAGRGREAELTALTDSTVERASARGEGFALAVIAYLRALLYNSLGRYADAVAAVRHEADPSGEAGLSTRAVSELVEAAAKAGDTALAGRALQRLTESTRAAGTEWALGVEARNRALLARDAAAEALYEEAIRRLASTGLRFELARAQLLYGEWLRRQRRRGDARRHLMAAETAFEAMGADGFADRAGRAILATGQLVRRRVDDTRFDLTPQERQIAELARSGLSNPEIPTRPFASPRTVEYHLGKVFAKLGIRTRGELPAVLGTGPGRGPGRGPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV58</accession>
    <name>A0A7K0JV58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_12030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000598">
        <property type="protein sequence ID" value="MST33444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="207"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="534" mass="60283" checksum="A69F2A311D087359" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV81</accession>
    <name>A0A7K0JV81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000758">
        <property type="protein sequence ID" value="MST33875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_114" evidence="1">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="30777" checksum="FFD8BA23C00D2724" modified="2021-04-07" version="1">PAATAGARHRPVWQPKGFLEWQWELDHPLSLHSARDMGLDTRASNGDRPPRTVPKVFDIDAVLNPASTIAALHRRGDRAICYVDVGTAGNYYTAAQEGIPRTYFAQLRADGDLGHQLQGYPEYFIDITARSAVRIVESMIARQCARKHFDAVETDLDETFGTNEGVTGFPITVADELHYLETLAGYLHARGLAWFAKNLDDTGRPAFIDALAPFAQGVITEQCNQFHTCSLLRPFLAAHKPVLDAEYYLPPARFCPADNAAGISGARFPLSLAGGRLPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC2</accession>
    <name>A0A7K0JVC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000762">
        <property type="protein sequence ID" value="MST33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="466" mass="48118" checksum="3250EA4EA0AFDF4B" modified="2021-04-07" version="1">MLSRRRSRCFAATVSARSHYSRFAPSNGTGARVPHRGANLDATSGATLRQSDGFSLTGRSRPGKNLTYDLGAALRLQTIGAGLEPWPRVVRRVDMRTTLVACLLALVVACGGCGHISTAGTSASSTPRSSSLCSLRELTVREYGQDGVAGTANTVFTITDDTAHACMLPRWASLGASWGSGATAKRLTGERSALPFRPAIPAHLPVSLEPQAANAAGILIRYRDINADNGSCHLITTFTFSLHGPTRPVQLRPPSSEVTWQACAGPDRMPPVSISALYPLAAVASAVQPLPRTTPTSTTTTVNPTTTSTQRPATTACTGSQLRTTEKHWPGGYLGYGLGHSGAVILFTNTSRRTCSLHGYPGAAGINSSGIQVTQARRTPSGYLGGLWGTTTAAPTVTLTPGDTASATIEGTDNPVGNATTCPTLAGLLVTPPNTSVPVHLPAAPADCSGLVIHPVVPGAKGAANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN0</accession>
    <name>A0A7K0JVN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000810">
        <property type="protein sequence ID" value="MST34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="442" mass="46351" checksum="6D8C96A82F4031E5" modified="2021-04-07" version="1" fragment="single">MNRQIRLVGAGIMVLFVAIFVKLNYLQLVHAKALNNSPTNGTKVVNEFDKPRGAIISSDGVTLAQSVAAPKGSSFAYQRLYPTGPLFADVTGYYSFIYGADGAEKTYNDLLTGAVQKSGFPTNLTDLQQLLTAKSSAQNITLTVNDKLQQVARNGLAGRDGSVVALDPSTGAILAMYSNPSYNPESLSQLSTVAEEKAWKQLLAAPGNPLSPGAYRNIWPPGSSFKVVTSSAVYDRKPSLANKSFPRLSGLPLPQTSHLLHNFAGEVCGGQILELFTVSCDTGFGKIGLDLGAHNLYREATQFGFDAVPPIDLPAAAASVFPKPSTFVANRPTLAYSAIGQEDVAASPLEMAMVVGAIADHGTMMTPHILASVSNSQGRVVSHYTDKVWKHATSPATAAKVTTLMESVVNSPNGTGVAAAIPGVEVAGKTGTAETGSPPSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS6</accession>
    <name>A0A7K0JVS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000829">
        <property type="protein sequence ID" value="MST34055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8356" checksum="6BB1957525165469" modified="2021-04-07" version="1">MSGGTAGGRTRRRPGVTTGTVTDFDAEVGLGEVGADDGTVVRFHCTQIADGSRSIAVGTPVSFAVVPGRGGRWEAAAVAPRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU5</accession>
    <name>A0A7K0JVU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-ribulose-5-phosphate 4-epimerase AraD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araD</name>
        <name evidence="3" type="ORF">GHK86_15265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000838">
        <property type="protein sequence ID" value="MST34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="24984" checksum="79221E52304F0B96" modified="2021-04-07" version="1">MAELRAAVLEANLLLPRYGLVTLTWGNVSGIDRAAGVMVIKPSGVPYERLRADDLVAVALDGTVVEGRLRPSSDTDTHLQLYRNFPDIGGVVHTHSTHATAFAQAGREIPVLGTTHADLAPLAVPVARALSEAEVADRYEESTGTILVEAVGDQGPARVPAVLAPGHGPFAWGADPRAAVEVAATLEEVARMALLTYQLAPGTGPLPAHVRDKHFSRKHGPGATYGQGGGPHDPVAGSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW04</accession>
    <name>A0A7K0JW04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000866">
        <property type="protein sequence ID" value="MST34140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="1">
        <location>
            <begin position="126"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="387" mass="42136" checksum="3F33EE534618C808" modified="2021-04-07" version="1" fragment="single">MAESFPRQHARTRRFTLGAPRSFRVSPDGRRVVYLRSAAGDDPRTSLWCLDLDGGGERLIVDGTAVGGGAETAEERARRERVRESASGVVGYSLDRDARRAAFVVGGTAFVAELDGSGAHPVALPTPEVFDARLDPDGRRLAWCASGALWVAELGDDGRVVDGSARRLAADDDPAVRWGQAEFVAAEEMGRRDGYWWAPDGRGLLATRVDDGPVPTVWIADPAHPRQPPAAHRYPLAGSADADVSLWWIGLDGGDPREVTWDRERFPYLPALRWPPGGDGRPLLLVEQRDHRAAQVLAARPEDGSTELLAERHDPAWVAWAEGTPDRLADGRLLWSADLDDTRRLTAGDEALTPAGLQVRAVVAAGETVVFTAWSDPTTVELWRWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW10</accession>
    <name>A0A7K0JW10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_15510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000860">
        <property type="protein sequence ID" value="MST34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="17803" checksum="B168B9CBBE38F7FC" modified="2021-04-07" version="1">MSSNERPPSELVIVQSPNAEDGEEPSAETVEQPAKVMRIGSMIKQLLEEVRQAPLDEASRTRMREVYDTSVKELASGLSSDLREELDRLTLPFGPGEVPSEAELRVAQAQLVGWLEGLFHGIQATLFAQQMAARSQLEEMRRRSLPPGSDEARPTTPGTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW57</accession>
    <name>A0A7K0JW57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000889">
        <property type="protein sequence ID" value="MST34186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20970" checksum="A3E63A42282768FF" modified="2021-04-07" version="1">MLLHEDKDFGTFGRFVETPVAEMDDVTRNAYDFTLNLRGLVPGPHKIWLANPKLLETIAPIGSYFQKDSTLTKAEIELATCVITGHWRASYANYEHERIAERLGGLPPQKVEALLAGLPVAFDDARQQIVYDLASTLAGARALPAGMFRRAQELLGDRGIVDVTVLLGWFSAVSLTLLAYDVPSNAVGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW75</accession>
    <name>A0A7K0JW75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000864">
        <property type="protein sequence ID" value="MST34132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="19525" checksum="571A7FC1D3B605DF" modified="2021-04-07" version="1" fragment="single">GAGGLLWIESPSNPLLAVADVPALVAGAHTAGFDVAVDNTFATPLLQQPLRHGADVVVHSATKALSGHSDVLLGVAVTTRPDLHAALRRRRTLHGAAPGPWEAWLALRGIRTLALRVERSQANAGELARRLQAHPGVERVHYPGLPEDPGHERMRRQMAGAGFVVSFVVRGGGAPAEAAEAVAAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM0</accession>
    <name>A0A7K0JWM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000948">
        <property type="protein sequence ID" value="MST34333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="18520" checksum="5AEE6E45F52009CB" modified="2021-04-07" version="1" fragment="single">VPADRRARLLGGGEEAEHRQATVAFIEFSGIDALTEAGGGELVARHLDPVICAAQAAAERFGVNFHETDIGADGGKVVLLGGVPLQRGNDAERALRVAHEVVAGHPADSPVRLRAGVNTGRVFVFCHEFARAGRRVFAVTGDAVNLAARVMGRAAPGEVLATRATLDGVVHPFETTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN6</accession>
    <name>A0A7K0JWN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000963">
        <property type="protein sequence ID" value="MST34358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16964" checksum="6D3F57CA6AFF974E" modified="2021-04-07" version="1">MAGVERATGAAPASGARLTYLVKQLELAIRADMDVMARAHGLTTLQYTALTVLRRHPGMSGAQLARRSFVSAQAGSEMIATLERKGLISREPDPGNRRILRVSLTSEGDAVVDACDGWMDKLEKQMVHDLGAPERKALRAALDSCIRALSPPGADGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV7</accession>
    <name>A0A7K0JWV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium-translocating pyrophosphatase</fullName>
            <ecNumber evidence="11">3.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_16750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="11"/>
    <dbReference type="EMBL" id="WJHE01000966">
        <property type="protein sequence ID" value="MST34362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST34362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="775" mass="79297" checksum="7B4E0D3C5F32B8C1" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX1</accession>
    <name>A0A7K0JWX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001009">
        <property type="protein sequence ID" value="MST34445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="37568" checksum="910CDEB52422F9D5" modified="2021-04-07" version="1">MQISTFLGYDGGFQEAARRVADYERVGLDLVWVAEAYGFDGPSFMGFLAARTERVQIASGILPIYSRTPTLIAMTAAGLDALSDGRFQLGLGASGPQVIEGWHGVPYDAPIGRTREIVEICRAVWAREAPLVHEGRYYQLPLPAGRGTGLGKPLKIIAHPLRPRIPVWLAALGERNVALAAEVADGWLPILFIPERADQVWGASLRAGRAKRDPALGPLQISAGGLLAIGDGDDVLAVRDLARPMVALYVGGMGAKGRNFYNDLACRYGFEKEAAEIQDLYLAGRKKEAEALVPDELLALTSLVGPRSWVAERVAAFRDAGVTHLQVTPVPAAGRDELGLLEELRQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX4</accession>
    <name>A0A7K0JWX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_17185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001010">
        <property type="protein sequence ID" value="MST34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="22512" checksum="D7DC49FBD794091F" modified="2021-04-07" version="1">MLLGEEPAPEAARAVEQYLVLTVDHGFNASTFTARVIASTGADPGAAVVGALGALSGPLHGGAPSRALETLEAIGEPEAADAWVRSAVARGERIMGFGHPVYRTVDPRSVMLREVALGLGGGLAARAVAMEEAITATLAELHPEQRLAANVEYYAGVVMATCGLARELFTPTFAVSRVIGWCAHIDEQAGSRRIIRPSARYVGPPPPQPIPQLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX50</accession>
    <name>A0A7K0JX50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_17535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001048">
        <property type="protein sequence ID" value="MST34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="105"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="331" mass="36898" checksum="8603FD928507389C" modified="2021-04-07" version="1">MQVLRPERPDEPVELPAGRPPAVAAPRTPWWQRKSIIPYLLIAPATLCELLVHFIPMIAGVVMSFYGLTLFTLHHWSTAPFVGLANFRVAVNVNGPIGQALLQSVEVTIPYTILAVGISWVIGMVAAVGLNVEFRGRSWLRSALLVPYALPVYVAIIVWSFMLQRDNGVLNTLLVRDLHLLHSPPFWLLGSKAFWSMLAAAVWRWFPFAFLILLAALQNIPNELYEAAAVDGASSWRQFRAITLPSVRSANLVLVLVLFLWNFNDFNTPYVLFGNAPPTAADLVSLHIYVVSFESWNFGLGSAMSVLLMLFLMIVSAVYLRVLRRGGEFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX51</accession>
    <name>A0A7K0JX51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pstA</name>
        <name evidence="10" type="ORF">GHK86_15490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000858">
        <property type="protein sequence ID" value="MST34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="86"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="32006" checksum="D0A25EA2280B0DED" modified="2021-04-07" version="1">MVGLSLGQEGATPGDLLTDSSARTAGRGRRIANGAGWGLGYLALVAIAGPVVWVLAGVFARALPHWQWKVLWTTGAAGTGGLLNEIVGSLLLLLGVAILAGAVGLGTGIYLAEYSKGRLGGFLRTASEVLAGIPSIVLGYVGYIAFVVTFHWSFSLLAGLITLTLMGIPYTAKSTELALRQVPTGYREGADALGMPATHALRRITLRTALPGIATGLLVALALSLGETAPLLYTAGFTSSLPSLQLTHAPVAYLTYAVWTFYNQPSAQAVDLSYDAAVILVVLLLVILVVSRLVVGRSQRYSETSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX84</accession>
    <name>A0A7K0JX84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="362" mass="40022" checksum="2113752C3DBD36FB" modified="2021-04-07" version="1">MTEQPISWSQAARVATAIAGRQPAMAVYERDAMAADFAELTALAEGLVEGETGLRSLAGPARARVIDRVGWVEVNIASFQRLLKPLADRLAATPSTGRRLPRPPDAFTAAVSGAQVGLLLAWMSTRVLGQYDQLLVEDDRPEDQDYVYYVGPNVAAVERRYGFPPREFRLWLALHEVTHRAQFTGVPWMRDHFLSLVERTIADVDPDPKRLLAAVRRAADDLRAGHSPLDDGGLLAVLATPEQRAAIQAIGGLMSLLEGHGDVTMDRAALQRIPNAALFSRTLRERRRQRGATRLISTLVGLDAKLRQYEQGEEFVREVERVGGRPLFDRVWQAPEWLPSLPEIRQPASWIQRAGAVHPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC3</accession>
    <name>A0A7K0JXC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001090">
        <property type="protein sequence ID" value="MST34596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="23700" checksum="08C801A763B46E5E" modified="2021-04-07" version="1" fragment="single">MTDVVAREGSAAPDVGRPKASPVGPVDRRRVSVSTGVIAAGLAAVVLVVRSIPRGGVLSAVLTFSLGIVALPMMASVLEWFVHRFVYHQAVIRPLTAIFTVHTAHHFAYFPTWRYVTGGPARRLSIRRRAPEAHRSPMRNAGVRLAHFSWYLAIGVVVVWTPAWYATRSVPFVAGLIASTAVVSNLFIAVHDTIHRPGSHHIVEAQPWFAFLDRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH0</accession>
    <name>A0A7K0JXH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000905">
        <property type="protein sequence ID" value="MST34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029462357" evidence="1">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="15728" checksum="53762DEF13862EA5" modified="2021-04-07" version="1" fragment="single">MRVAGAGHHPPAVFGTAANLQIASAVLAVAARSAGPASAAGNLSLVGAELQTAGGYTLQGMMGISGLTVPASADGGALVDQGGEVVGITTDLTSVDSSMQGVAFAVPIDTAEHVAVQLLAGQKPADPWIGIQDATDVSTMTASQDGIAGGAEVGAVAPGSPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL2</accession>
    <name>A0A7K0JXL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chorismate_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001152">
        <property type="protein sequence ID" value="MST34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="522" mass="54808" checksum="3835DFDC53A6A8AE" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP3</accession>
    <name>A0A7K0JXP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.101</ecNumber>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="7"/>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001181">
        <property type="protein sequence ID" value="MST34735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="26990" checksum="7340780AC174E18C" modified="2021-04-07" version="1" fragment="single">PARTSGTGATPLRPAGGWPLIVFSQGYAISPAAYSLLLESWTREGYVVAAPSYPFTTPGAGPLDEADIVHHPAELAAVVAALSHPGGVLAGTVDAGRVGLVGHSDGGDVTDAAVNNTCCRIDGVRAAVILSGAELTSFPGTYEPDAAVPLLVVQGDEDPINPPGCGQQIYDAQTGARYYLDLLGAGHHSPYLDPADLAAFRDSDLARAPAYRRVVDAVTLAFWQRYLAGSTHTAASIESAAADPGLAALTAGPAVPIVGACPGAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT9</accession>
    <name>A0A7K0JXT9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">GHK86_18855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001207">
        <property type="protein sequence ID" value="MST34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10332" checksum="28DE7776955E80A9" modified="2021-04-07" version="1">MSLQPLDDRIVVRPSEAEETTASGLVIPDTAKEKPQQGEVLAVGPGRRAENTGELIPLDIAVGDKVVYSKYGGTEITVDGEDLLILTSRDVLAKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV2</accession>
    <name>A0A7K0JXV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001214">
        <property type="protein sequence ID" value="MST34788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="23903" checksum="4AA4D3BAAE3E94EF" modified="2021-04-07" version="1" fragment="single">MSDRGRIVVIEDDPAIARLVEMYLQRDGFEVAVAGDGRAGLEAVRDPATVLAIVDLGLPGGLDGIEVCRRIRSAGDLPLMILSARRAEDDRVDGLEVGADDYVTKPFSPRELIARIHALLRRSPDRPPADALVDIGTLMVDPGRHEVRVDGRPVPLTPREYELIAFLARHRGQALSRDRILDGAWGPGWYGDDRTVDVHVRQLRAKLGDALPLTTVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY14</accession>
    <name>A0A7K0JY14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001260">
        <property type="protein sequence ID" value="MST34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="17115" checksum="15B08FE556223695" modified="2021-04-07" version="1">MDALSLAESVTIDCPPEVLYDMVADVTGMGEWSPVCKACWWEDGTPGQVGSTFRGRNETPERTWETVSTVVVAERAREFAWVVNGGWVRWGYRFEPAGAGTEVTESWEMLPAGIEGFRGRYGEEADAQVAQRRQAALAGMPVTLAALKAAAEAATAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY22</accession>
    <name>A0A7K0JY22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3048 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001247">
        <property type="protein sequence ID" value="MST34840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3048" evidence="2">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="3">
        <location>
            <begin position="178"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="32332" checksum="35D6EE72B0822173" modified="2021-04-07" version="1">PPTTAPAPRPTCPLSGQPAPGGKVPQRAALAIKVGNDPGAWPQSGLDRADIVIEEPIEGAMTRLVAIYQCNESAAVGPVRSTRWIDDQMLPQFGHPGFAFAGGIIPDEALVHAAGLVDLNFDRVPGAYVRTSSRYPPENLYTSTAALWKAMGSGTAPHPIFHYGSPTEAGPPVTAATLEFSSSYSVGWQWVPSLHLWLRTVDGSVDRTAAGHPLHAANVVIERVDTVSGTWPEDVNLALGVHSITVGSGPLVVLTGGRAVSGTWSRSSTAVPARLVTTGGTPITLAPGPTWVELLPRGGFVTGSLTLHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY91</accession>
    <name>A0A7K0JY91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001313">
        <property type="protein sequence ID" value="MST34935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029792033" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="20637" checksum="436998391D773CC2" modified="2021-04-07" version="1">ALAPAARLVVGMSLGGLASLALAAAHPELVPSLVLVDITPGVDGSKTRAITDFVSGPERFESFEEILERTVRHNPGRSEASLRRGVLHNAQRLPDGSWSWRWDPHRGHPSEVENDVEAGHGFASLWEALGATRMPLTLVRGSRSPVVDDADVAELRSRRPDARVVTVDGAGHSVQGDRPLELAALLAPLLAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD6</accession>
    <name>A0A7K0JYD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2510 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001320">
        <property type="protein sequence ID" value="MST34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2510" evidence="2">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="7508" checksum="E85541568D7BD1E4" modified="2021-04-07" version="1" fragment="single">MPTTLPTPGWYPDPASPVDGERWWDGRGWTDAVRAASTVGDHRLPPGAHAAPTAPAGRGSNGWGAPPPGETAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD9</accession>
    <name>A0A7K0JYD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001337">
        <property type="protein sequence ID" value="MST34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="10240" checksum="B2EC62F2C430B4FD" modified="2021-04-07" version="1" fragment="single">MTRTVGERYKWIALSNTTIGILMVTISSSITLISLPDIFRGIHLDPLTPGNTSYFLWLLMGFLLVTSVLVVSLGRVGDMFGRVRMYNLGFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE3</accession>
    <name>A0A7K0JYE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001066">
        <property type="protein sequence ID" value="MST34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="16240" checksum="30CA2A45405B4EE9" modified="2021-04-07" version="1">MAQLRGRGIVVELPPGFEGRILQRAPVGGGIPQPVVHLATFALPPGTADFGGGATPLMGPDDVFVVLFEFGAESVGRELFRARGLPRSVRPSELSPFRLRRGIDGQAGGQWFFTEAGRPFTLYVVVGSFAARARLAARVGELLAGVRVETRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ8</accession>
    <name>A0A7K0JYJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001358">
        <property type="protein sequence ID" value="MST35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029584115" evidence="1">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="6570" checksum="2BBBEF0271DCAA6A" modified="2021-04-07" version="1" fragment="single">MTVLASSPVLLMAPAAMAAGAPHAPGHGLAGARRGAEAVLKQDARRLAAVSSHEQASKVINATDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM8</accession>
    <name>A0A7K0JYM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001122">
        <property type="protein sequence ID" value="MST34644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10198" checksum="BB1E7F390F76CA3C" modified="2021-04-07" version="1" fragment="single">MPDRPPADGAWQRVDRAYADLLTGYEDDDRWLLEQTIVSAPSRRAVHGLLPLPAGATVLDLGTGFGVVAQELAASTGCRAVGLDVDVDRLGRAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ6</accession>
    <name>A0A7K0JYQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001422">
        <property type="protein sequence ID" value="MST35091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="428" mass="46533" checksum="30E981A9396AEE28" modified="2021-04-07" version="1">MSLIDRDQVDRRCDVLVVGGGPSGSACAYWLASAGHDVVLLERKRYPREKTCGDGLTPRSVRQLEQMGLTEELAVAGHRYEGLRSHGFGRTLELTWPSHPELPGYGYVITRKDLDALVAERAAKVGVAVWERAEATAPIIEGGLLRGAVVTRKDAPDAAPVEVRARYVVVADGANSRFGRALGTTRNRSYPLGMAIRGYYESPLHAERWIDSWLDIRDRAGNVLPGYGWIFPVGDGRVNVGVGLLSTFNQWKAVNTTHLMESFVEYAPAAWDLRPETACGPPTGGRLPMGLSVGPHVGPTYLVVGDAGGTINPFNGEGIAYAYETGRMAADAVHLALASGDGMALHSYQDALTDRYGLYYRVARTFVRVIGHPEIMRVLVSTGMRNRSLMEWVLRIMANLLRPDELGPAEAAYRALAALARVVPQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ0</accession>
    <name>A0A7K0JYZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-activated pyridoxal enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001490">
        <property type="protein sequence ID" value="MST35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-ser_dehydrat" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11616" checksum="68E0F7BC03209744" modified="2021-04-07" version="1" fragment="single">AVATEIQAGSYVLMDTAYGQLGLPFGQALTVLATVISVNRSGRWVVLDCGLKALGMDHGNPSVPGGEVWACSDEHLVWSPVGVDPLPAVGDRVHVIPGHCDPTVAYHEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ24</accession>
    <name>A0A7K0JZ24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabT</name>
        <name evidence="5" type="ORF">GHK86_21085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001523">
        <property type="protein sequence ID" value="MST35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="455" mass="46937" checksum="FBC224ED74C500D3" modified="2021-04-07" version="1">MVQTESRTGSQPGAIPQQRVLRTELPGPRSRELAARRSAAVAPGVSSTLPLYIDAAEGAVLVDVDGNALIDLGSGIAVTTVGHAVPAVVDAVRDQVGRFTHTCFMVGPYEGYVEVCEQLNALTPGDHDKTSALFNSGAEAVENAVKIARRATGREAVVVFDHAYHGRTNLTMALTAKNMPYKDGFGPFAPEIYRAPMSYPLRDPSGMTGEEAAQRAIELIERQVGAARVACVLIEPVQGEGGFVVPAPGFLPALADWCRANGAVFAADEVQSGFCRTGAWFACEHEGVVPDLVTTAKGIGAGMPLAAVTGRSEMMASVHAGGLGGTYGGNPVACAAALAGIATMREGNLGAAANRIGETIAGRLDPLVAELPGIAERRGRGAMQALEFVKPGTLEPDSAAAGRIAAACHAQGVVVLTCGSWGNVIRLLPPLTISDALLDEGLGVLIDATRTVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF3</accession>
    <name>A0A7K0JZF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_21340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001562">
        <property type="protein sequence ID" value="MST35262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="22791" checksum="B0B4F777F5E118BB" modified="2021-04-07" version="1" fragment="single">FVAVAARSDASAGFAVYLVAVVVGFGWLLLARDRADGEAVAAGDRVRPLRMVREHRRGFATSGVGAFGIMLLRGSRTAIIPLWAAHLGLGSGSAASIYAWSSLVDLALFYPAGAISDRWGRRAVAIPCIALLSVGHALVPLAHSATSLFLVAFVLGFGNGLGSGIVMTMGADLTPAVGRASFLAVWRVVSDAGNTAGPLVDSVVVGLLSLALAGPVVGLLGAGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF7</accession>
    <name>A0A7K0JZF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001324">
        <property type="protein sequence ID" value="MST34954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="33804" checksum="03F5A84BBAAC084C" modified="2021-04-07" version="1">MARYLLKRLGLAVLTLVLLSVIVFLAGQVLPGNPGRAVLGHTASAQAVAAFNHKLGLDRPLVVQYWSWFTGLLQGNLGQSYQYQAPVGQYLGPAILKSLKLAAVAFVIVVPLSIIGGVVAALQRGKAVDRVISTTGLSLSTVPEFVSGIVLIVIFAIELKVFPPGANPPPGAGFGATLYHLILPAIPLVFVLFGYIARMARAGTVEALESDYVRTATLKGLPRRTVVTRHVLRNSLLPTITVIATQTGYLIGGLVVTETLFNYPGLGRLIFNAAQNKDFPMLEAGVMIIGIVYLAATLVADVLYTVLNPRLRLQGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI0</accession>
    <name>A0A7K0JZI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001660">
        <property type="protein sequence ID" value="MST35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="11100" checksum="AD743C5085FE74CA" modified="2021-04-07" version="1" fragment="single">VEGWGQPAYLPAGIGRARRPRGATAALLSPFDSLIWFRDRALRLFDFHYRIEIYVPAAKRVHGYYVLPVLVGDRLVARVDLKADRPAGVLRVAGAWAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K061</accession>
    <name>A0A7K0K061_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001499">
        <property type="protein sequence ID" value="MST35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8953" checksum="2954047D2B392901" modified="2021-04-07" version="1" fragment="single">MTDHHDVQELLGAYALDALEPDEVAAVEAHLEVCARCRRELAGYREVTSLLGHTGGEAPPGIWDRIAAGMHPEPSSPPLERIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K084</accession>
    <name>A0A7K0K084_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001517">
        <property type="protein sequence ID" value="MST35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10789" checksum="1C6D0DE539F85FB2" modified="2021-04-07" version="1">MIPEEHVLARRRALHHLVDESRRMAAGHRLGSPEHDFYAGVRTAAEDGLSPHHRDAHGEAWLAAQAGPFRDGYTRTAAMIAASHHELSHRYQVPDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K090</accession>
    <name>A0A7K0K090_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001522">
        <property type="protein sequence ID" value="MST35214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="8418" checksum="E1405776A72FBB4C" modified="2021-04-07" version="1" fragment="single">NRLSGGQKRRLDMAIALVGDPELLFLDEPTTGFDPAARREAWDAVRSLASLGKTVVLTTHFMDEAQYLADRVAVMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0D6</accession>
    <name>A0A7K0K0D6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folK</name>
        <name evidence="9" type="ORF">GHK86_21350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001564">
        <property type="protein sequence ID" value="MST35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="15826" checksum="83810CDCE57491B0" modified="2021-04-07" version="1" fragment="single">SGSAARRRAYLGLGSNLGDRWAHLAGAVASLPDVVAVSPVYETDPVGGPPGQGAFLNAVVELDTTLGPYELLAAARRAEEAAARVRLERWGPRTLDVDVLLVGTATVDDPPELVVPHPRMWERAFVVVPLADLAPDLVAAHPAARELLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0V2</accession>
    <name>A0A7K0K0V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001686">
        <property type="protein sequence ID" value="MST35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="10655" checksum="32AF3C06882B25A7" modified="2021-04-07" version="1" fragment="single">MVDAADAPAEGPVERLDAVTLAVTDMARSVAFYETLGFGRASGGGAATFTTFRAGPGFLNLQHQPAGPDQGGRWGRVIFFVDDVDAMHRRAVAAGLHPETAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMN5</accession>
    <name>A0A7K0JMN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="27593" checksum="2AE1BC669B2E1E74" modified="2021-04-07" version="1">MTSTPTAGPVVDTLAAQEFIGEIHRRLDHRDIEAMTAGLAAKATRVRSLLAPDRPAPGLGELHWLLRSCFPSRRQTRAILDAVGVDALGTAMRSLVHGDGDLGERVERFDACLAGFPEVATDLPWELLHLARPDRYWLWTRWMWNPRTETGALALVTAEDVELSAPGPVESYERVGRALAMVHGTVRAVDFAGDGPFGIDVFLACVYGIYMYTVLRMRMTQEFTRIVPELPALCRRLLGIYHREVLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMP9</accession>
    <name>A0A7K0JMP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome accessory factor PafA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000018">
        <property type="protein sequence ID" value="MST31205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="500" mass="55399" checksum="62B42A1DE6DC3478" modified="2021-04-07" version="1">MALAKVLGLETEYGILIKGSAEPNPIAASSALINAYVAALSRRVKWDFEDESPGRDARGFAREGSSPPEIETHLVNAVLTNGARYYVDHAHPEYSTPECSTVREIVLYDKAGELILARSVEAAGRLLPPGQRVVVLKNNSDGKGNSYGTHENYLMDRAVPFTRIVQHVMPHFVTRQVYTGAGKVGCEATGSGTRHVGFQLTQRADFFEEEVGLETTLKRPIVNTRDEPHCNAQKYRRLHVITGDANLSETATFLKVGTTALVLSMIEDDWFVRAGARDLTLQAPVAAMRRVSYDLGLHEPLALADGRSMTALEMQWEELDLARKYAEDLGTDAVGGTEAGAEILRIWEEVLTGLESDPLSLATKLDWVAKYRVVDGYRQRHGLAWDDPKLALMDLQYHDVEPGRSLFARVGMDRLVDPRDVERAVTEPPETTRAYFRGRCLQRWASSIAAANWDSMVFDLGSDPLRRVPMMEPLRGTKAHVDQLLNSVSSPAELLERLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMR0</accession>
    <name>A0A7K0JMR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000010">
        <property type="protein sequence ID" value="MST31157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046229">
        <property type="entry name" value="TnpC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19776">
        <property type="entry name" value="DUF6262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14335" checksum="B91CC3D5CEF0867C" modified="2021-04-07" version="1">MATDNSHHLHAAQRLHHAQLVERVETVLRNLEKSGAPVSFPAVAEAAGVSRAFIYKTESLRCLVDRLRQVNRATAGPAIPARQRRSEASKDALITRLTQENRALREQNKTLADQNAALLGRLRAGAGGEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN25</accession>
    <name>A0A7K0JN25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="81"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="25910" checksum="F9C59F45FAD34E9C" modified="2021-04-07" version="1">MVDTLEVRLGQARAGQIGHAELLHMLCVDELERRDAAAIDRRIKTARFETAATIEDFDFAYNPKLPVAAIRDLATLRFVEASESVILHGPVGVGKTHLAQALGHAACRRGHSVAFTKTSRLLADLAGGHADRTWTARLRRWARPDVVILDDFAMRDLSLAQADDLYEFVTERAGRPIIITANRAATDWYSLFPNPVVAESILDRIINGAHHLHLDGRSYRPNKRPRPNRNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH3</accession>
    <name>A0A7K0JNH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000088">
        <property type="protein sequence ID" value="MST31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="PTHR34002"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029800271" evidence="4">
        <location>
            <begin position="34"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="548" mass="58967" checksum="60027485C4E9EE55" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ6</accession>
    <name>A0A7K0JNQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000106">
        <property type="protein sequence ID" value="MST31610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10099" checksum="E4D4B207C1FC3FC0" modified="2021-04-07" version="1">MPRSVRGNNLPGAAAAPATGPGQVIHRVCLDCDTVLACSEPQRQDPPSAYGWCRHGGGAPVAVFDDFGAAVAPTSLHHCNGRLRAAHRWADRSADTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT4</accession>
    <name>A0A7K0JNT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="10094" checksum="BF03D3BE2D7DF8A5" modified="2021-04-07" version="1">MVTSNPPVGSPMEKALAAARRAGVDLNDERAVQKAALAEAIRCLDHAGMKRKALERHALAMAAEARRAMYANGSTDEDARQAAVDAYRRHGGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU9</accession>
    <name>A0A7K0JNU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000093">
        <property type="protein sequence ID" value="MST31541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="174" mass="18045" checksum="902114339B51D100" modified="2021-04-07" version="1">VGLDRSAAFLAAAGEGRWVRADARRLPFPPGSFDAAICLCQGGFGLLGGPGDVEAFGALASCVRPGGRVAVSAFSSYFAVRHLEEGETFDAAEGVVHEVATVRSPAGEEAPFDLWTTCFTPRELRLLAAGAGLAVDGLWAVAPGRYGRRPPDLEHPEWLLVATRAAGRVAGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW1</accession>
    <name>A0A7K0JNW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="20584" checksum="0E0866FD93C3E8E4" modified="2021-04-07" version="1">MVAIEDEGFALDMVCMALDVPAGVLTSEESKKRAAAAQLARRMPVFANSLWIFEQPDHTPDQQVLDSLTGTINSLVRAVELVSTGWSSGQLDPLLGGFPSPDSRRPWELLHEMAHELSRDMTSLWPSYDVVAATVDDALATAQGSTTAPSDPRRLTFATYFITTLVRVLAEWVGRKGWPLSWETPTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY8</accession>
    <name>A0A7K0JNY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000031">
        <property type="protein sequence ID" value="MST31289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="765"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109288" checksum="2495E153075D6306" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ8</accession>
    <name>A0A7K0JNZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000117">
        <property type="protein sequence ID" value="MST31688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="71"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="311" mass="34902" checksum="E8A9D6386C3040C0" modified="2021-04-07" version="1">MGPRRDFVGYGRRPPAVRWPGDASVVVNVVINYESGAEYSLPDGDGRNDTWGEYSYQVGPEVRDLGTETHFEYGSRAGIWRLTRLFDRLRLPVTLGACAVALQRNPELAEWVTGTGNDVIAHGWRWTDVAGISRDQERAEMARAVEVLRELTGSHPKGWYLRSFPSVHTRELLVEEGGFLYDSDSCNDELPYFVDVQGRPFLVVPYSKVYNDVRYLLAPTYATPRHFYENLRSGLDYLCDEAARGEGRRMMTVGIHERWSGQASRASALADFLEYAADRADVAILGRAAIAEWWIAHHAEWDGPTAAGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP84</accession>
    <name>A0A7K0JP84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">groL</name>
        <name evidence="9" type="synonym">groEL</name>
        <name evidence="12" type="ORF">GHK86_03370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="478"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="554" mass="58485" checksum="C73DE318757F32CE" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA5</accession>
    <name>A0A7K0JPA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_03510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000139">
        <property type="protein sequence ID" value="MST31796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="305" mass="33922" checksum="A317744AFE304E52" modified="2021-04-07" version="1" fragment="single">MAPGAATLTEGLNPVQAQAVTHPGGPMLVIAGAGSGKTRVLTHRIAWLIDQGVSPFEILAITFTNKAADEMRRRVVELVGRVAERMWISTFHSACLRILRRDAGRLGYRSGFTIYDQADAVRLTGYVVRDLGLDAKKFPARAVHAAISAAKNDLVDFETYRAQAAGIHERRIAEVYREYQSRLLAASAMDFDDLLTVTVTLLESFPEVLTHYQQRFRHVLVDEYQDTNAAQNRLVLLLAAAHRNVTIVGDSDQSIYKFRGADIRNILQFEEAFPDAVVVPLEQNYRSTQTILDAANAVIVNNTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE3</accession>
    <name>A0A7K0JPE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_03755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="273"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="349"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="7">
        <location>
            <begin position="432"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="552" mass="55951" checksum="86DDDE017617AFD0" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF4</accession>
    <name>A0A7K0JPF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_03415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000132">
        <property type="protein sequence ID" value="MST31777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="29579" checksum="58600A3D7B3EFF1F" modified="2021-04-07" version="1" fragment="single">MTTTELPPDPAVLEPLGEADGPCQKQMFDQVALAVFLIVPFAALVAAVPLLWGRGLGWRDVAIAVVMYAVTGHGITVGFHRHFTHHSFRAARWLQVALAVCGSMAIQGPIIQWVADHRRHHRFSDRDGDPHSPWRYGRGLAALTKGFFYSHIGWMFEWEQTSQTKYAPDLCADRAVKRVSQLFPLWVTVSMLLPPLVGGLWSWSWQGAWWAFFWGSLVRVGLLYHVTFAINSVCHLSGRRPYRTKDRSGNVWWLALLSMGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM5</accession>
    <name>A0A7K0JPM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">nusG</name>
        <name evidence="10" type="ORF">GHK86_02035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000086">
        <property type="protein sequence ID" value="MST31509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="74"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="27693" checksum="DBD8AF0F6F57934D" modified="2021-04-07" version="1">MSAPDEAAADDVLEAEARAGADEAVDDEEAVADAGPEVADADATGEPVATDAVEALEEEPAPPPRRPESPYDRPGAWYVVHSYAGYENKVKSNLESRIASMNMEERIFEVVIPMEDVIEFKNGKKQVVSKKVFPGYLLVRMDLDDDSWYVVRNTPGVTGFVGLGARPTPLSRKEVENILQVTPEAETEGPRKGRPRLEYEMGESVRVKEGPFADFTGTIAEINEDQLKLKVLVNIFGRETPVELEFAQVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN1</accession>
    <name>A0A7K0JPN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000168">
        <property type="protein sequence ID" value="MST31895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9101" checksum="A6925A60425E1FBF" modified="2021-04-07" version="1">MSKRRRSSGGRKALEAKFWGRSPGADAPRSIRPTPEPGALVRSLGAPPLAIDPAIAERHLIAVYEEAVKAATALAAANGLLDASADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR2</accession>
    <name>A0A7K0JPR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF427 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="13409" checksum="0BEF776A0432EEBA" modified="2021-04-07" version="1">MSTREVKIPGPDHPITIRPAGTRVVARVGDEVVAETDAALALQEASYPEVLYVPLADVRPEVLRPSATSTHCPYKGDASYYDLLAGGRELTDAVWTYREPYDAVAAIAGYVAFYPDRVDVAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ03</accession>
    <name>A0A7K0JQ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_02730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="467" mass="49995" checksum="82D485AB42E5746B" modified="2021-04-07" version="1">MVATDEAGAAAVLEKHTIAPIPLTERHGRPRDLFTIWFSSNVMPLTFVTGALATAVYGLSLPWAVVAIVVGNGLGAFLMALHSAQGPRLGVPQMIQSRGQFGYIGANLVVGIAIIMYVGFATSNLVLGGQALNALSPHISVDAGAIVCAAISLVITTVGYDLIHKINRWLVPVAVASLIIGFVAVPLVHGISAKELHAGSYSFAGFLGMVSIGALWQIAYAPYVSDYSRYMHPEEKVSSTFWNSYWGCNLGSIVPMILGALVGLLAATNQVAALDRDTGGIGWLLMIIFFVAITNTNALNLYGGMLCTITFGQTFRSAMRPGARARAGVSVAIMVVSVLIATAIKGNFLADYNNFDLLLFYFLIPWTAINLLDFYLVRRGRYDVGSFFQPDGGVYGRFDVRALVAYAVGVAVEVPFWDTPGLYVGPLAKDLQTDISWLVGLAVTVPLYLLIVRARRERTPEAVAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ59</accession>
    <name>A0A7K0JQ59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="11958" checksum="317F3D04DA93E787" modified="2021-04-07" version="1">MPATDLTYQPAGDRRHQIAWTAAGLRRAAAGAGVTLPVDFARAVAADGLERADQLAVSRAGAGVVIHTCPATPRQLPVLLGYADARGQWHRDGRRHQPTALPAEQPAAPGLGPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC6</accession>
    <name>A0A7K0JQC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000224">
        <property type="protein sequence ID" value="MST32150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14081" checksum="DB0A1D42E304C63C" modified="2021-04-07" version="1">SPGYPTEGDRDISRFLTDRPPPPGAAELFLPYQIVVADGRTVVGGIGCHRPPDETGTVEIGYGIAPEWRNQGITSEAVGLLVERLRDGGVRTVTARTAPANLPSQAVLRHNGFTQGGLGHDGFVLWLLVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF4</accession>
    <name>A0A7K0JQF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000231">
        <property type="protein sequence ID" value="MST32176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15247" checksum="49E3FDE2B952EE20" modified="2021-04-07" version="1">SAYNTVFADSAGRAVNVEASATDCECSGPDERGAIVHTNHYVSARMAAYEDDPGYAVHSARRRDRVLELLDRPGALPVDERGLRAILSDHGSEPDAICRHPGLGTEVKTVFWCVADVTEGRIGYGRGNPCHSLEQRYAFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR37</accession>
    <name>A0A7K0JR37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_06610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="39"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="354"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="614" mass="65325" checksum="F90368F7470F03D1" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR98</accession>
    <name>A0A7K0JR98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Toprim domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_05185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000217">
        <property type="protein sequence ID" value="MST32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="234"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="368" mass="39225" checksum="3CE2BF0B63992455" modified="2021-04-07" version="1">FPRHGHPDRTPSLRLYLDDDRYYCFGCNARGDIIQWAQDAADLTVTDALRLLDSHQPIPNAWAGAAPQPPSTQVSPAGSGPDPTRTPPERVHAALDAAWTHYTTGEHHGLAVGYLARRGIDITVLERLTGRAEAGATGGRHSLVETLTAEGFAAEELVDAGLARWGSEPRILIDAYRDRMLVPVRDETGRVCGLVGRYVGDRKAPKYLNPPRTATYDKSINLYRPLPAPTCRLGRVVVVEGTLDALAIAVASVRAGTAERCCPVTQSGRELSAVQVRSVLRLSQRPPVLALDGDSAGREATSRLLGAFAAAGVRPTVVSLPEGEDPASLLARDGLRSLRSLDGSRSPVHPGASATPRQPACSAAVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD4</accession>
    <name>A0A7K0JRD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="52"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="28520" checksum="D7D494A8D839542D" modified="2021-04-07" version="1">MTAARRTGTSRSVGLRRNPGVFLRWVELTPDAPRGGYPFELPAVRGLHTVRFRQVTFLAGDNGSGKSTIAEALALLAGFNAEGGSKHLRFETFATHSTLGEHLRPVWQDRPRWGWFLRAETFYSMASHIASDDELAPKFGHLHRESHGESFLDLALSRFHDQGLYILDEPEAALSAQGQLTLLRLMHDSCAEGSQFIVATHSPMLMAFPGAAIVHLDSSGPQELAWEEVPAVQLWRRYLQDPDSVLRHLLEDDPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF4</accession>
    <name>A0A7K0JRF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpsC</name>
        <name evidence="11" type="ORF">GHK86_07225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000315">
        <property type="protein sequence ID" value="MST32512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="26025" checksum="D5024AE9097295B2" modified="2021-04-07" version="1" fragment="single">MGQKVNPYGFRLGVTTDWKSRWFNDREYQDYLIEDWEIRHYLMSQLERAAVSRIEIERTRDRLRIDVHTARPGIVIGRRGAEADRLRTKLAEITKNPKVQLNIQEIKQPELDAALMAQGIADQLAGRVSFRRAMKRTVQTVQKAGALGIRVQCAGRLGGSEMSRREFYREGRVPLHTLRADIDYGFREAKTTYGRIGVKVWIYKGDILPYKVSAEDKISREAAMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH2</accession>
    <name>A0A7K0JRH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2510 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000323">
        <property type="protein sequence ID" value="MST32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="3">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="32583" checksum="2994BCF245D25BC3" modified="2021-04-07" version="1">MTRARHPGWYPDPDDPTLLRHWSGRQWDSRRRHVPAWSIATEEFRLLDPSEPPSEPTPDGPVHTEALPAVMAPFGSGSTRRRLALPPPNWRSPAPSSFGDRPRTGPTVRPRQRWLAGPRRLASLMVVVALIALTVSGAVNAGLRRPGNSLTADTAFLRDANAACVATLGAVRPVAAPSGTTGGPTTPGGRAGGEAAGGGTAGVGAAGAVATVAAVQAARSQLSGLSRRILQLARAPHATAYVTGWLRLWAAWGTARVRQARDATAGTSGGPSPAGVSAAAAAQSDVRQADAFANHHGLNDCTLQGVPTTTILPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH9</accession>
    <name>A0A7K0JRH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000325">
        <property type="protein sequence ID" value="MST32540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="3"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="475"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="509"/>
            <end position="516"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="781" mass="82153" checksum="16F818B866477CC4" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK4</accession>
    <name>A0A7K0JRK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000330">
        <property type="protein sequence ID" value="MST32562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="9985" checksum="DC3245099E65D472" modified="2021-04-07" version="1" fragment="single">MPLGATTLDGVSLELPSPLDDEERSEPAVGMVTTGPSGTTTWVRTGDGADVELVEGPGPASVERVALATAGGTVDDGAAAAAVGGGAAAGGPAGAEAAGLPATGSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL1</accession>
    <name>A0A7K0JRL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase Nlp/P60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000333">
        <property type="protein sequence ID" value="MST32570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029667605" evidence="2">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="213"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="34259" checksum="FBBAA7E2EC6F35F1" modified="2021-04-07" version="1">MKSLIVAMVLLAAAACLPVAAALTAAAAAGGAVLSAAREPVLPTPPPSTGPVAVPGIPLPYLEDFVASGARFDVPWPVLAGIYRVECDFGQAQLPGCNPVGTENAAGAQGPGQFLPGTWRVGLSPHELIPPGPPTSSDAQGFATDGDGDGIADPWDPADAVAATARLLRADGAPGDLPGAIWSYNHSSAYVDEVLALARRYAVEARSAGAAQGAAVEAVLAFARSQLGVPYLWGGASPAGWDCSGLVMAAFARVGIVLPHNAELQYEQTAGEGVPLDQVQPGDLVFFGTSLATIGHVGIVVGAGAMIDAPHTGAVVRVESYRWPDLVAATRPLAAAGGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL9</accession>
    <name>A0A7K0JRL9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">GHK86_05755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000250">
        <property type="protein sequence ID" value="MST32229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="6735" checksum="5DB2A2DA15385EC4" modified="2021-04-07" version="1">MPKNDKRVKVTLACDVCKRRNYITVKNKTNDRERIEMKKYCRWDRQHTLHKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP7</accession>
    <name>A0A7K0JRP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaN</name>
        <name evidence="13" type="ORF">GHK86_07585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000335">
        <property type="protein sequence ID" value="MST32583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="128"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="243"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="365" mass="38682" checksum="1EC298C18A2DB5DD" modified="2021-04-07" version="1">MKLRCERDVLVEALSTAGRATAGRSGALPVLSGVRLETRGDTLMATGTDLDLTISTEATVTGLDDGVVVAPGRLVTDIVRALDPGAVTVEAEEEDLRITSGRSVFSVRTHPAADFPRLPTPSGDEVTLPVEGLAEALRQVVRAASSEDSRPILTGVLMAAEEGGLRLVSTDSYRLAVRDLAGVGILAADQKVLVPSRALNELGRLLGGSGEVSLRLGAHDATFRTGSVSLTTRLIEGEFPNYRQLIPASYPNRLVVGREAFLEAVRRVKLLAKDPVTPVRIALAADGIQLAVITPDWGQAAEDVDAKYEGAEMTVAFNPTYLIDGLEAVPGDEVVLSTLDALKPATLRPVEGEDFLYLLMPVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ1</accession>
    <name>A0A7K0JRQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">GHK86_07825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000346">
        <property type="protein sequence ID" value="MST32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="220" mass="22492" checksum="BA8ADD8BE1E52C2E" modified="2021-04-07" version="1">MAEITLVAEPGRATGSAASRRLRTAGRVPAVVYGHGVDPASVSVDGRELRIALSGSSGVNQLLSLDVAGTRHLALARVLQRDPVRGTVTHVDFQVVSRDEVVSAEVPVALVGEARAVEQERGVVEHVLASLTIKAKPGSIPEVVEVDVTDLRIGDTIRVAQLPLPAGVTTDVDPDEAVVVAAGSSVTTEVAEEEAEAEAEAEAAAGQGEAEETGGTAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU9</accession>
    <name>A0A7K0JRU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I glutamate--ammonia ligase</fullName>
            <ecNumber evidence="5">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnA</name>
        <name evidence="5" type="ORF">GHK86_06150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000266">
        <property type="protein sequence ID" value="MST32304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="453" mass="50488" checksum="32D49E2BABA72AA6" modified="2021-04-07" version="1">MEQQKDYVLRTVEERHVRFVQLWFTDVLGVPKSIQITPAELEVALEEGLTFDGSSVDGFSRVQESDVLALPDATTFQLLPYLADGTPTARVVCDVVNLDGSPFEGDPRQVLRRALDRARGLGLSFFAAPELEYFYFARDGAGDFAGVTDGLAPPVPLDHGSYFDLTTNDLGSELRRQTVLTLEEMGIPVEYNQHEDAPSQHEIDLRYTDALTMADTIMTVRMVVKELAARRDVVASFMPKPLAGVQGSGMHLHLSLFDGGTNAFHDAEDPYHLSPVARQFIAGLLRHAHELTAVTNQWVNSYKRLIVGYEAPVYVSWARNNRSALVRVPPTKAGKPDSTRIEYRAPDPACNPYLALAAVLAAGLAGIEGRYELPPELATNLYDLRSDERRELGIEALPSSLADAVDRLEQSKLLADTLGEHVFEWFVRNKRAEWVAYRSEVTPFELRRYLPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV3</accession>
    <name>A0A7K0JRV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000354">
        <property type="protein sequence ID" value="MST32665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="18001" checksum="AAA72395D165E3DC" modified="2021-04-07" version="1">MQDTVLVPRPVEDVVSALSSGCVALIGASLAGIDADAAEARGRVGPLRSPAGLGKTVEVRRGPLRRHGEATLLAFSWSATGGGALFPDLDGDLEIRPVELDRTLLTLRGRYEPPGGRIGQRMDHLVGHHLAEATIRAFLAALADRLTEGLSRTPCPDRKGAGPEGSTHQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX5</accession>
    <name>A0A7K0JRX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000364">
        <property type="protein sequence ID" value="MST32698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="29180" checksum="1D4ADB640523C765" modified="2021-04-07" version="1">MRSVQALVLTHNSPSTLRRTVEALLAQERRPDAVVVVDNAGRVPAAVTLAELVADGAVRVLRCEDNTGPAGGWATALGHFLQSGLDAAWLLDDDIVAPPRTLTVLLEELDAGWSYVLPSVRQPSGAVTTYPAWHGVLLDRQIVERAGLPRADFFWWSEDTEYLMWRMAKLGHPLHVTDRVVVDHLKGRGARGNPPWAYYYEMRNSVYSHLWLLHGRGRWPRKVAGLTARALLEQRRWACLRLSALGAADGLLGRLGKREEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY9</accession>
    <name>A0A7K0JRY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000362">
        <property type="protein sequence ID" value="MST32687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="75"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="290" mass="30870" checksum="FED99DD89BD93C69" modified="2021-04-07" version="1">MRAPPGLSCFQRPGEEWRRSVSPATHSRRGCDDRPYSSCRDGRDSGRTAAKRGMTGGGAVTAQSEVIWPHTAMTTIVLVGEPQLVAQGLVAALSAAPDIVVGIAHDVREALALFEREQPDVAVLSRRVIQWEGPAAVRRLRAAFPDVQLALLTPDPVENPLRAVLSTACRGYATEDASVGELAELLRVVARGGTMTVGTPPPAGDRDATGAHGQGPALTQREQEVLEALSTGMTPVAIARSLSLSEHTVRNHIRHLLAKLDAHSRLEAVIAAARLGLIDLRDPGVRDQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS29</accession>
    <name>A0A7K0JS29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_08330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000370">
        <property type="protein sequence ID" value="MST32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="254"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="275"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="694" mass="75005" checksum="71A909D52B6A74A4" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS62</accession>
    <name>A0A7K0JS62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000387">
        <property type="protein sequence ID" value="MST32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029655828" evidence="1">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="28083" checksum="276B81AE6413C066" modified="2021-04-07" version="1">MGRHRTVALLGAVVLSVVVVGGVLAAAIPTGSRPRNCPQLFVPAFFRPDDGWAALAKAPAPPGTVLLDLTSLGAGTAPEAGFRPAVAALQKRGVTVLGYSTTIYTHRPMAQVVADVRHYASWYGVHDIFLDQVATGVGQLAYYRALQARIRAVEPKAMIWLNAGTYPARAYMGLGDIVVAFEGPWSNYRAIAVPGWARRYPRSRFAFVVYATPASHLAGTVRLAQRRNAGHLYVTDGTGGNPYGSLPSYFPALDAATAGCASQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS85</accession>
    <name>A0A7K0JS85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000389">
        <property type="protein sequence ID" value="MST32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_21" evidence="2">
        <location>
            <begin position="423"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="613" mass="65546" checksum="94493CBE01D9E535" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD8</accession>
    <name>A0A7K0JSD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000404">
        <property type="protein sequence ID" value="MST32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="18515" checksum="A92F66111DD39098" modified="2021-04-07" version="1" fragment="single">MTTTAVETAAAVRSGERPALEVLDEHLARIGERDGELHAFLAVTGDAAREAAARVDAAVAAGLDPGPLAGVPIALKDNLCTRGVATTCGSRILEGWLPPYDATVVGRLAAAGAVVVGKTNLDEFAMGSSTENSAFGPTRNPIDPSRVPGGSSGGSAAAVAAGFAPLALGSDTGGSIRQPAALCGVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH0</accession>
    <name>A0A7K0JSH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsS</name>
        <name evidence="7" type="ORF">GHK86_07235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000315">
        <property type="protein sequence ID" value="MST32514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="10617" checksum="8ABCFA40130C1621" modified="2021-04-07" version="1">MPRSLKKGPFVDDHLLKKVDDLNSRNEKRVVKTWSRRSTIIPDMVGHTIAVHDGRKHVPVYITESMVGHKLGEFAPTRTFRFHAGQERSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL0</accession>
    <name>A0A7K0JSL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000435">
        <property type="protein sequence ID" value="MST32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="348" mass="37592" checksum="7347C93616021A17" modified="2021-04-07" version="1">MAARPDLEIIEYRPEPDEYAWTFGGAAPVRRLAPGTVVECWTEDCFAGKVRSTDDLSTVVCEYPHFNPQTGPFWVEGAEPGDTVAVHFVSIEPARDWAASTTVPLFGALTATHLTAMLHEPLPEVVWIWRLDRDARTCRFEARDGSWGVDLPMDPMHGTLGVAPANLEVRSALVPDAFGGNMDTPELRAGVTCYLGVNVPGALLSLGDGHARQGEGETCGVAVECAMDTVFVVDLIKGVPCPWPRLESDTHLMSTGSARPLEDAFRIAQADMVGWVSGEFGLSPLDAYQLISQAVESPIANVVDTNYTSVAKMAKRWLPPRDAMDGTHRRLAAVAEAYRASGRRAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN5</accession>
    <name>A0A7K0JSN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000437">
        <property type="protein sequence ID" value="MST32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="11644" checksum="4DDDEAF417F8ABCB" modified="2021-04-07" version="1">MIASLQLQLGPLVYLIVPVAVAVLLIVVVTLRHRRPKSLEANVESFNRGLQALSPDAPSGRRRRRRSAPVSSARPPARTVVPTRMGTGAMAVTSSTTPRPAAGAPASGADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS1</accession>
    <name>A0A7K0JSS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_07460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000330">
        <property type="protein sequence ID" value="MST32559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="381" mass="40094" checksum="79B9193B4D1EA52D" modified="2021-04-07" version="1">MAAVRDTVRLGRIGGVPVGLNWSLIVIVGVFAFALAGNRFPIDAPGYHKEWYAVAGVATALALLASVLAHEFGHAYVARRAGLEVEGITLSWMGGVTRIVGDARTPRGEIAVAAVGPVISLLLGGVFVGIGFGASAAGVGNLTVVAIDWLAVINIVLAGFNLIPAAPLDGGKILHAVVWWIARDRWRATHVSSRAGLLLAGGVAALGLYEILGRGDEVNGLFVLVLGWWLLNAARDEEQLAKVQHLLGGVPVHDVMRPVAAAPGWLAREEFVERYARLYPGWVWLLERWGGGYNAVIAGDTLMAAAPTPPGTRTVELALPVEAAAGADPREEVLAALERSGGHRLLLVVEGERTVGAVLPADIETILRTRHRPGPTVAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS7</accession>
    <name>A0A7K0JSS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000450">
        <property type="protein sequence ID" value="MST33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="13257" checksum="D0ABB3F5E4C2CACC" modified="2021-04-07" version="1">MRHVAMEFPGEPESVREARAFVGDTLEAWGLPSAVEVAVLLTSEVTTNAVRHAGGPFEVTVEERTPEVLVKVRDGSARPATLRVVPVDAENGRGLPMVRILADRWGSTTLAAGKLVWFAVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX1</accession>
    <name>A0A7K0JSX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxiredoxin</fullName>
            <ecNumber evidence="8">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_10010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000469">
        <property type="protein sequence ID" value="MST33052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="211" mass="23316" checksum="60B59D18D7AECDFD" modified="2021-04-07" version="1">MALQLGDEAPDFTAETTEGTIHFHEWLGDGWGVLFSHPKDFTPVCTTELGATAKLKDEFARRNAKVVAISVDSVESHKGWIPDIEETQGTSMNFPIIADPDKTVANLYGMIHPNASDTVTVRSVFWIGPDKKVKAMLTYPQSTGRNFQEILRVLDSLQLTSKFQVSTPADWTSGGDVIIAPAIDDAAAKEKFPKGWETKRPYLRLTPQPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT01</accession>
    <name>A0A7K0JT01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029670315" evidence="1">
        <location>
            <begin position="27"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="31596" checksum="6C10EAF31179C75C" modified="2021-04-07" version="1">MFRVLLAAGVVLRILIPGLTGPTAPAATGQRYWLGTDSSGVALAGRGPFREPRLGGAYGGYFGMIGDWALWQGCGHYRLAWSSADAAAASFDLRRYGRGVGTDGYWFMGGPGVDPRYDGTVGEAAAWGAAQARRALLDLAGSHLQGGVLWMDVELPGSTVFDPVPDNGWNVVYSSTCSPRAVGQVPATLDRAELDGFAGWVRAHSGVRVGVYSSPLVWPAIFGAGPQATVHHLLEWTYTDGTASLARRPEAWCLAGTATCARFFGGVSPTSADAAVWQWSGGGGITNGVGDFDQIDAGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT02</accession>
    <name>A0A7K0JT02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000470">
        <property type="protein sequence ID" value="MST33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="29"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="345" mass="37193" checksum="127F98A9D62567BA" modified="2021-04-07" version="1">PAPAGIDPSGVTAWFATHVPAAEPPLAFRLIAGGRSNLTFAVTDRSGHRWVLRRPPTGHLLPTAHDMGREHRIISAVGPAGIPVPRALGYCDDPAVTGAAFYVMEFVDGHILRVEGDAAAAFDPAGRRRISEHLVDTLAALHALDPDTVGLGDLGRRDGYVARQLRRWYGQYCANRDEQDGPDVPDVDRVHDHLAARIPEQGPAGIVHGDYRLDNTVVAADGSVAAVLDWELCTLGDVLADVGQLLVYWAEPGESSVLAHTATTDGGFLTRAELADRYARVSGRSLDRLDYYVAFAYWKLACILEGVYVRYVRGAMGQDGFDFGGYPDMIRDLAGRASAAAERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT68</accession>
    <name>A0A7K0JT68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANTAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000388">
        <property type="protein sequence ID" value="MST32784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="20645" checksum="BD87A994EBBFEE3D" modified="2021-04-07" version="1">VSLLHGGPGGGRFRTVSASSDRVREVDESQYRSLAGPGIDAMRSGVEIAATLNGRWPSFTADAGAVGIRAAWSLPLRVGDATIGALNLYSYGRPLWDERAGVLARALADQAAVVLANVAALSEAELANRALRRALRTQELIGQAEGILMARQHIDGDAAFDVLRRASQRTNRKLRDLAAEIVDSVSRPAPGPPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT88</accession>
    <name>A0A7K0JT88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000503">
        <property type="protein sequence ID" value="MST33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="15587" checksum="10580C4F2DFB84E7" modified="2021-04-07" version="1" fragment="single">MGEAPAATTSARGWAALGAMYLLWGTYYVSIRVGVRQFPPFLLVGIEFEIAGVVLYLAARRFEPASRAGLTARQWRKAAVAGTLLLVGGDGLVSVGEQHVAASVASVLIATIPLWMVVGDLVRGRLRWGWPLLAGLAVGLGGAALTAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT98</accession>
    <name>A0A7K0JT98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000507">
        <property type="protein sequence ID" value="MST33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="4">
        <location>
            <begin position="148"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="29571" checksum="57B3C8E718DCC250" modified="2021-04-07" version="1">MDDNEARVRLETLTETVRRDLDCEPEATRDAPCPELPEGATPANRRNELERELRLMGPINPLALEEFTALQERHAFLESQLEDVRGGRRELTKVIKAIDEEIVEVFRAAYADVADNFEKLFGTLFPGGQGRLRLTDPDHLLETGIEIEARPSGKNVRRLSLLSGGERSLTAMAFLFAVFRSRPSPFYLMDEVEAALDDVNLHRFLGLIHEFRDEAQLVIVSHQKRTMEAADCLYGVTMPPGGSSRVVSERVGAGGSSNRDPAGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC7</accession>
    <name>A0A7K0JTC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000406">
        <property type="protein sequence ID" value="MST32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="204"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="31926" checksum="F22284401A3BA0A9" modified="2021-04-07" version="1" fragment="single">MPAVTVDNVLTLPRIAPPDPAAARQRPVRSVTTAPAGFEGEGFPVRRAFAGVPQSELDPFVHMDQMGEVEYAPGEPKGTSWHPHRGFETVTYIIDGIFDHQDSNGGGGRITNGDTQWMTAGAGILHIEAPPEHLVISGGLFHGIQLWVNLPSANKWNPPRYQDIRGSEAKLLSSGDGGALVRVIAGQVAGHEGPGSTFTPITLLHATVSPGAQLDLPWPAEYNALAYVLAGRGSAGTEGRPLRVGQLAVFGPGDAITLAADGTQEARSPNLEVLVLGGRPIREPVVHYGPFVMNTREEILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG6</accession>
    <name>A0A7K0JTG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000420">
        <property type="protein sequence ID" value="MST32884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALO" evidence="2">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="12296" checksum="33917EAD5AEDC65B" modified="2021-04-07" version="1">RALAGALARAAFVCEIRAVAADDLWLSPAYRRATVAVHVTWRPDPAGATEAIAAVEDALAPYDPRPHWGKLSGMEPAALAVAYPRLDDFRAVAEALDPERTFANRFVDQALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ2</accession>
    <name>A0A7K0JTJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000538">
        <property type="protein sequence ID" value="MST33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="27442" checksum="B1B6E620BDE351CE" modified="2021-04-07" version="1">MTATYTASEMMAVAASRALADRQVCFVGIGLPSTACNLARATHAPHLVLIYESGCIGAKPTRLPLSIGDGELADTSDTVVPVPEIFNYWLQAGRIDIGFLGAAQIDRRGNLNSTVIGDYDHPAVRLPGAGGAPEIASAAREVYVMIRQSPRTFVDRLDFRTSVGFGDGPGDRERLGLRGGGPKKVITDLGILEPDPETAELVLTHLHPGVEVDAARDATGWDLRIAPDLARTEPPDAGELAQLRRLEATQPTQKKGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN8</accession>
    <name>A0A7K0JTN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mycothiol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000554">
        <property type="protein sequence ID" value="MST33305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9676" checksum="CD526DCA9966F960" modified="2021-04-07" version="1" fragment="single">MVRIERKEHLAPEEVGAINELLAAATAADDHAPLDEHAWLDLVQGGRGGYGGLVAVEEGHPHPIGYAQVTRGPDSWAVEYVVDPHHRVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY8</accession>
    <name>A0A7K0JTY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000580">
        <property type="protein sequence ID" value="MST33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="15171" checksum="E6799A75379BDBF2" modified="2021-04-07" version="1">MPLVPYVPEEEATGEVRAVYDEILASRGLTRVPNFWRAIAHDPAYLRAEWEKLKAVMAERLLDRRTKEIIAVAVSATNNCDYCLHSHTDNLRAMGMTDAELVELLAVVDFFNGSNAVASGLKVDYEPPVSEGGPGPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU43</accession>
    <name>A0A7K0JU43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uroporphyrinogen decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000593">
        <property type="protein sequence ID" value="MST33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="28758" checksum="A1EDB16190AACD7C" modified="2021-04-07" version="1" fragment="single">MTGCVIAAPSASPPGQREGGGYGGPVPARSPVFLDACRGRAVPWTPVWFMRQAGRSLPEYRQLRREGSILDVVRRPELAAEITLQPVRRYGVDAAILYSDIVVPVAAIGFGVDIVPGVGPVAEQPFASRADLGRLRELEPDEDVPWVAETVRILVGELEVPLIGFAGAPFTVASYLVEGRPSREYLRTKALMHGDPTTWHALVDRLASIAVASLRAQVAAGAAAVQLFDSWAGALDPDDYRRFVLPATRRILTELADTGVPRILFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU47</accession>
    <name>A0A7K0JU47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000603">
        <property type="protein sequence ID" value="MST33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15151" checksum="C07B48AB4410B1D5" modified="2021-04-07" version="1" fragment="single">MADLDQTARRLATLLTGGGSGLSDPTARELQFEPTVTLRPLERLAPPPDVWAVDGGQALVADARCLQLYVTRAATVRWTGGRCVQEEEGPLAAHLLGLGEGRAALAATGAPVDADAAVDVNLLRDWGEWQAVAAAVDACEPGGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD2</accession>
    <name>A0A7K0JUD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium:proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000626">
        <property type="protein sequence ID" value="MST33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="32"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="18575" checksum="3C9463B4CFAA0E35" modified="2021-04-07" version="1" fragment="single">MGGYSRPPAPSSVTDVDRFALILLASAGAGLLIIASSRLTARIRVPLPAIVLVGSAAVAALVPSVRAPSRPVDVDIVTVALIAILFDGGMSIGWRAFRSAVVPIALAGIVGTFATAIAAAGVVRVVVGAGWYAALLLATAVAPTDPTVVFSVLGNRRVGGRSGTIIQGESGANDPAGIALMASLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF9</accession>
    <name>A0A7K0JUF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="81"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="31507" checksum="29C8191DE06D5E1A" modified="2021-04-07" version="1">MATAIGTAVVMCLRGTSRTSGRGGLVVSDSAAAVREFDRHERDRWKGRASAYEASVGALCAFTAPLVLDAAGVAAGWRVIDAGTGPGTLARLAAERGALVVALDGERGMLELARTHLASAVFCEAVLPRLPVRGGWADAAVANFVINHLGDPPAGMAEAVRVVRSGGKVAVTVWPSPPPALQRLWGEAFDAAGVTRPEGLPRVPEDRNFARTPRGVTDLLCGSGLRDVDCETITWSHRTDLESWWSGPAGGIGTLGVLMRGQPAETVAAIRREYQRLANGYLNSDGTLALPTAALLAVGTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH1</accession>
    <name>A0A7K0JUH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000637">
        <property type="protein sequence ID" value="MST33563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007136">
        <property type="entry name" value="DUF347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03988">
        <property type="entry name" value="DUF347"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="290" mass="30989" checksum="6B6634B6459FB034" modified="2021-04-07" version="1">MSGAAGPSNAAAGRATPYGLKVPVRITAAFWAIKVLSTAMGEATSDALVHGLDQYLGVLIGFALFVVAMGLQLRARRYDPWRYWFAVAMVAVFGTMVADVLHIGLHIPYAVSSAFYLVVLVVVLRLWSRMEGTLSIHSIFTPRREALYWLTVLCTFALGTAVGDLTATTFRLGYLGSGILFVALFAVPGLAYRCVRADAVLTFWSAYILTRPLGASFADWMGFGPAVGGLGLGHPVTAVVFLVPIIGLVTWVARTGIDMPGCSRPLRPTGAAPSSGRRPAVDQDRRPAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI7</accession>
    <name>A0A7K0JUI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000657">
        <property type="protein sequence ID" value="MST33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="19514" checksum="BBD4931685D329AA" modified="2021-04-07" version="1">MRSSPAAVPAPPEPGTGTSFGVYVHIPFCAHRCDYCAFATWDDRPQLAPDYVLACRAEIDRAVDGGMPAATSVFFGGGTPSLLPAGDLVSILDAIPRRDGVEVTVECNPEHADPDRLAAWRRGGVTRLSFGVQSMGPVRARTARPAPRSRRRPTRRRRCRIGGVCRGVQRRSHLRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK3</accession>
    <name>A0A7K0JUK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenide, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">selD</name>
        <name evidence="8" type="ORF">GHK86_13015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000668">
        <property type="protein sequence ID" value="MST33635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="52"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="171"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="34064" checksum="B78A7D9A1512D4F7" modified="2021-04-07" version="1">MQTPSAAAVRLTSLAHGGGCACKIAPGELEAMVAGLVGVPSPSLLVGLDDGDDAAAVRLHGDQAVISTVDFFTPVVDDPYDWGRIAAANALSDVYAMGGTPILAVNLLCWPVDRLPRELATEVLRGGLDVATLAGCPVAGGHSVDDPEPKYGMAVTGVAHPDRLLRNDAGRPGLPLSLTKPLGLGTLNNRHKQTGEVFPEAVATMAQLNADASAAALAAGARCATDVTGFGLLGHLYKLARASGVTAVVDHRAVPYLEGAREAMAAGHVPGGSRRNLAWVAPHTRFEAGVDELEQLLLADAQTSGGLLVAGEVPGAPVIGELVAREEATLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW7</accession>
    <name>A0A7K0JUW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000552">
        <property type="protein sequence ID" value="MST33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8604" checksum="F1FD03A305770F7F" modified="2021-04-07" version="1" fragment="single">MSAEILFVGAHADPGLGPRSATVGDLSGARAALRACRPPGVLVLALAALGPDPLARLRALTASPRPDPRCMSEPRHRHHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW8</accession>
    <name>A0A7K0JUW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000712">
        <property type="protein sequence ID" value="MST33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="12651" checksum="B11C95E699E627F9" modified="2021-04-07" version="1" fragment="single">PHAACDLSTIWSVAEASTSARILDAALHAFGTAGYEATSLDALAAELGIRKQTILYHFSSKEQLLDAVIDEAGLELIAAVGGGLDGVGPGWERVEAVVRAVFRLAGRRPELPGLLREVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV47</accession>
    <name>A0A7K0JV47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_13935</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="WJHE01000735">
        <property type="protein sequence ID" value="MST33813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="6"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="321"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="49795" checksum="5BDDBF169A90F450" modified="2021-04-07" version="1">MVDDSLSALEAGFLHLESAVTPMHVGSVGVYDGAGWHDRAGRLRLRALRAYIAGRLPDLPRLRQVPRWPAARSGRPIWVDDPDFDIARHVRARHLTPPGDEARLLDAVAAIHMQLLDRDHPLWSFTFLEGLPGGRVALVERLHHALVDGIGGVDLTMLLLDTAPLASSARRSPRVPAHPVQAAAPSAADGVAGTGLASLVREPLAVGRGLAAAAAHPVQAATATRQLASAVASVATRPLAPPSSLNTPIGPTRRYLVVRRSLPDARRTAHALHGTVNDVVLAAVTAGFQALLASRGEPPPPELHALVPVSVRTPDEHRALGNRVATLIVPLPLRVTDPGARFTATHRAAQHAKDHHQAQLATAILEFAEHWPEPAVAACSWLVQRQRIVNVVVTNVPGPPVPLYLMGARMLEVAPIVPLSRNLTVSVGVLSYLDQLAVGLWADADRVPDLPVLAAGIEDGFDALDALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG9</accession>
    <name>A0A7K0JVG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DhaL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000635">
        <property type="protein sequence ID" value="MST33554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="394" mass="40801" checksum="7DD3CEE8E21D966E" modified="2021-04-07" version="1">MLEVAERARSAAADALARTPEQLEALRAAGVVDSGGSGLLLLLDALLHVLDGRPLPACEAGPGALPDVGGVAAETADEGTASCRYEVMYLLDAPDEAVPAFREVWSGLGDSIVVVGGDGTWNCHIHTDDIGAAIEAALDAGRPSRIRVTDLFEEIEEERWVREAAGAAGTVEEPHAHCAVVAVCTGDGIRRIFASLGVHRFVTGGQSMNPSTADLLAAIEDANADEVVLLPNNKNVVAVAEAAAAAASKPARVVVTHGIQEGIAALLDYDPEGSADDNVVAMAASAAHVVGGEVTRAVRDSTSPAGPIAEGDYLGISRDGIRVVAPSVAEAATGLLELLIDVDHHEVVTIIAGEAAHAADTRRITEWIEERHPQLVAEVHPGGQPLYPYLLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH8</accession>
    <name>A0A7K0JVH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_14660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000788">
        <property type="protein sequence ID" value="MST33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="405" mass="43735" checksum="C0423793A45AFE6C" modified="2021-04-07" version="1" fragment="single">MPSKVLIANRGEIAVRVIRTCRELGVGTVAVYSELDREALHVRLADEAYALGGQTAAESYLDTGRILDVAARSGADAVHPGYGFFSENADFARAVTAAGLRWIGPPPEAIEVMGDKISSRIAAAKAGVAGVPGTTEVIRSADDVIAFGEEHGWPVAIKAAYGGGGRGMRVVASAAEAAHALESAQREAEKAFGRSESYLERYLTWPRHVEVQVFADRHGNCVHLGTRDCSAQRRHQKLIEEAPAPGIPAATLDAMGAAAVKVALACGYHNAGTVEFIYQDGDFYFLEMNTRLQVEHPVTEQVVGRDLVALQLAIADGEPLPFTQEEVVLRGHAFEVRLNAEDPAGGRFLPSPGTITRFYRPDGYGVRTDAGYDEGDTVSQYYDNLIAKLVTWGPDRESARRRMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI7</accession>
    <name>A0A7K0JVI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_14715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000792">
        <property type="protein sequence ID" value="MST33966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="34191" checksum="AED0EB3D3CA99B30" modified="2021-04-07" version="1" fragment="single">MPPGDGERSCSTLTATRTRRLLSIQPAADGGGSETALLRMLAALRAEGWECHVAVPHPARLAAEYAAAGATLHVVPMRRITTQGSTLAWAASYLAAWPFTVAALTRLARRLRPDVVHSNSLHSWYGWAVARLVRRPHVWHAREIVVQSGAALGLERALTRRCADLVVAISGAVAAQLDRPDVRVVLDGPAPGEFGPDRAGAFRAAAGIDDEVPLVGSAARLDSWKGFGVLLDALPLIRAERPEVQLVVAGPVVGGKEDLAGELARRARDLGGVHWLGPRREMPELMADLDVFWRLRLRRRPRPERSRRLLLRGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK2</accession>
    <name>A0A7K0JVK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4445 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000636">
        <property type="protein sequence ID" value="MST33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="622" mass="65435" checksum="053397E2E2246603" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP3</accession>
    <name>A0A7K0JVP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hisD</name>
        <name evidence="2" type="ORF">GHK86_14970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000814">
        <property type="protein sequence ID" value="MST34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="32245" checksum="DEB8660D5876B369" modified="2021-04-07" version="1">RELRRPVERAGLYIPGGRAPLASTVLMTAVPARVAGVATLAAVTPPGPGGEVHPAVLAAAAVAGVDEVYRVGGAQAVAALAYGTASIPAVDVIVGPGNVYVATAERLVAQEGAVGVPSAFTGPSEVAVVADGTVPLEWAAVDLVVQAEHGPDGLAYLITWSAEVAEAVTAAVDAIAAASPRRAEITATLERGGYAVLVDGPEQAMEVANVIAAEHLELQVADPDQLVPLVRCAGAVFNGPWAPASVGDYAAGPSHVLPTARSARFGSALRVDDFCRHIHVVDLDRAALAELAPHVVALAEVEGLAAHADSVRLRMAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP6</accession>
    <name>A0A7K0JVP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Benzoate-CoA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000661">
        <property type="protein sequence ID" value="MST33609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011957">
        <property type="entry name" value="Benz_CoA_lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02262">
        <property type="entry name" value="benz_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="294"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="391" mass="41552" checksum="225BF159DCDFB8FF" modified="2021-04-07" version="1">AGTGASVDAAVAVHRLAAVQDADPGEGGAYPSGEDGPAFWLYTSGTTGRPKGAMHRHGAVREVCETYGRQVLGIRADDRCLSAAKAFFAYGLGNSLLFPLSVGAAAVLEPSPSRPETMARRACEHGATLFFAGPTFFANMLKAQLPADALGGVRLAASAGEALPAALYRRWTEHFGVDILDGIGMTEMLHIFLSNRPGAVRPGTTGVAVPGYDLRIVDDGNRDVPDGTPGTLLVRGRSTATGYWCRYDASRLVFQGDWLRTGDTYLRDPDGYYRCLGRTNDVLKASGMWVAPGEVEERLMAHPAVGQAVVVGAADAEGLEKPVAFVILREGAAATEEDLVAFCREALPSFKRPRRIVFVSEYPTTATGKVRRVELRAQAAFALTAVAAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW22</accession>
    <name>A0A7K0JW22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000711">
        <property type="protein sequence ID" value="MST33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="415" mass="44185" checksum="9A9EE07C5F5772CA" modified="2021-04-07" version="1">MRVTPHRATSETLAGAYPFLAEEGLGTAGVLVGQDAWSGTAFCYDPWELYRAKAITNPNIFLAGQIGRGKSTLAKALATRFVAFGRKVYVPGDPKGEWTPVTQAAGGQVIALGGGRPARLNPLDAGIRPPGLSDAAWAAKLAQDRMTLLAALTEATLGRPLAPVERTALDAALSLACQASVPVLPTVVDRLHDPTAAYAGSSIDQLRADGRDAAHALGRLVRGDLAGLFDGPSTVAFDPALPMLSLDLSDISGSDTLLGLVMTCTSAWLEAALRHPDGGQRLVVYDEAWRLLAQPSLLARMQAHWKLSRAWGLANLMIVHRLSDLDAVGDHGTAARSLAQGLLADTATRILYNQPPDEADAARRILGLTTTQTRQLPDLAQGEGLWRVNQRAFVIRHLCTPDELTCFDTDARMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW30</accession>
    <name>A0A7K0JW30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000867">
        <property type="protein sequence ID" value="MST34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="33059" checksum="3230EF1655CABFA9" modified="2021-04-07" version="1" fragment="single">MTEPAPGASRPDGWPARAVVTGAAGLLGSHLCRRLVAEGSEVVGVDNLSTSDGTNLDDLGGHPRFRLVEADVTAGIPVDGPLDAVLHFASPASPPDYLRLPLETLRVGSAGTWHALDLAEANGARFLLASTSEVYGDPLAHPQDERYWGNVNPVGPRSVYDEAKRFGEALTAAYRRERAVDTAIVRIFNTYGPGMRPDDGRVVSNFLAAALRGEPLTLYGSGEQTRSFCYVDDEVAGILALLRSPLPGPVNIGNPAECSVAELARVVLEVTGSSSPVEHRPLPEDDPTQRRPDITLAASALGWGPQVSLRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB6</accession>
    <name>A0A7K0JWB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000916">
        <property type="protein sequence ID" value="MST34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="6145" checksum="EF375DBE1FAE7C2B" modified="2021-04-07" version="1">MAPEDDGSCPAGYPVKAKLRSGVYHLEGMAAYARTRPDRCYPSAEAAEAGGFRRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH5</accession>
    <name>A0A7K0JWH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxo acid dehydrogenase subunit E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000937">
        <property type="protein sequence ID" value="MST34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="2">
        <location>
            <begin position="34"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="251" mass="25770" checksum="CF55C860694E82AA" modified="2021-04-07" version="1">AGPAEAGAPAPAAAPAATAPAPAPAPAAGDRQASLRRAIGALMARSKREIPHFYLATTIDLGAVSSWLERTNAERPVPRRLVASALLLAAAARAVARAPELNGFFVDGGFRPGSGVHLGVAVSLRSGGVVAPAIHDADRLDPDQMMAALHDLVGRARAGTLRSSEMSDPTVTVTNLGDLGVDSVFGVIYPPQAALIGFGRVAERAVVRAGEVVAAPCVTASLAADHRVSDGHRAGRLLADIDRFLQRPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ8</accession>
    <name>A0A7K0JWJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000944">
        <property type="protein sequence ID" value="MST34318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="34913" checksum="D636886B4B89FB29" modified="2021-04-07" version="1">MGEATLAPPLRSDLGARDDVPAIATEKLTKRFGSFTALDGLDLEVRQGEVFGFLGPNGAGKSTTLRLLLGLIRPSSGSARILGTDARDVRHVHGRLAYVPGDVALWPRLTGAQCLTLFGRLHGSVDTALRDELVERFQLDTSKRARAYSKGNRQKVALVAAFATRADLILLDEPTSGLDPLMEAEFVRAVRDVASQGRTVFLSSHILGEVETLCHRVGILRAGRLIEVDDVSRLRTMHGTELDVDVDGPPPDVSHVPGVSRVDRTPEGIRVQLSGEPAPLIHALAPVNVTGLRSREASLEEIFLGYYDSDAAVDGHRDGGTGDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK5</accession>
    <name>A0A7K0JWK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">ftsZ</name>
        <name evidence="11" type="ORF">GHK86_14525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000774">
        <property type="protein sequence ID" value="MST33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="205"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="358" mass="37057" checksum="4A65A8BA765FFB65" modified="2021-04-07" version="1">MAGSAQNYIAVIKVVGIGGGGVNAVNRMIDAGLKGVEFIAVNTDAQALLMSDADVKLDIGRQLTRGLGAGSDPEVGRQAAEEHREEIQEVLKGADMVFITAGKGGGTGTGGAPVVAEVAKSLGALTIGVVTRPFSFEGRRRSEQAELGIQRLKSAVDTLIVIPNDRLLTVSNDKTSMVNAFKMADEILLQGVQGITDLITTPGLINTDFADVKMIMSNAGTAIMGIGTASGENRALTAAKLAITSPLLEASIEGARGILLNIAGGSDLGLFEVNEAAEIIHAVAHPDANIIFGQVIDDAMGDEVRVTVIAAGFDNSSPTPLARSGALGLDDGDGEMEGFQEEEGLARDDDFDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL2</accession>
    <name>A0A7K0JWL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000950">
        <property type="protein sequence ID" value="MST34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="25"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="303" mass="32806" checksum="BAA141BFB07F3989" modified="2021-04-07" version="1" fragment="single">MALDVTAVKKDFPIFDQEVKGKRLVFLDSAASSQKPRVVLEAMDEYYETTHANVHRGVYAIAEEATRRYEDARRRVGAFVGVEDPAEVVFTKNVTESFNLIAYAWGRANLGAGDVVVLTPMEHHANLVPWLQLKAERGIELRYLRLTGDGELDTAALDREVEGARLVSFTACSNVLGTLTPVRQVADAAHAAGALVAVDGAQLVPHAPTDVAALGADFFGFTGHKMLGPTGIGVLWARKELLEAMPPFLGGGEMIRDVRLDGFTPNDVPWKFEAGTPPIAEAVGLAAAVDYLERLGMEAVRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ0</accession>
    <name>A0A7K0JWQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000968">
        <property type="protein sequence ID" value="MST34366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="12648" checksum="C1FB05DA3B02194F" modified="2021-04-07" version="1" fragment="single">MSGLDELMGRVEEVHLPEGAVAALRRVAGSVRSSPVGGDILSGRRIRHPAHPALVVLPLGSWSAALLLDLLGGRSSRRAARRLTGIGVLGAAPAVLAGLDDWLDTTGPEQQVGALHAAANLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX07</accession>
    <name>A0A7K0JX07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_17395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001032">
        <property type="protein sequence ID" value="MST34488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="12747" checksum="C8CCACD8E60A7440" modified="2021-04-07" version="1">MPKPDVTIPEGAPPSELLVEDLTVGDGEEARSGQEVSVHYTGVAWSNGSQFDASWDRGEPFAFHLGAGEVIAGWDRGVQGMRVGGRRRLTIPPDLGYGSRGAGGVIKGGETLVFVVDLLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX56</accession>
    <name>A0A7K0JX56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001054">
        <property type="protein sequence ID" value="MST34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="32921" checksum="1EF90FDACBF72A6E" modified="2021-04-07" version="1" fragment="single">MAEPYPPAHRLDIEETLAGGRVVRDPYRWLEDPDAVETVVWSTEQDERWAAWAAAHPERAPLADRILALTPGFRSAPVVIGERRFWTERAPGQDHAVLLVEDGAGRRALVDPNALDPDGTVVLDGWAPSLEGDRVAYLLSSGGDEESTLWVIDVATGFTLEGPIDRVRYSPLAWLPGGEELLYVRRLPPWEVPAGEEAFHRRVYRHRVRSHAQTDDELLFGQDGRGPDVEPTAYLGVEVSHDGRYVAVTVSLGTAPRNDLWVAELPAAGEVPAWRPALVGADAQAQPAFDRRGNLWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX60</accession>
    <name>A0A7K0JX60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_17585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001053">
        <property type="protein sequence ID" value="MST34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13077" checksum="A7CC502F556BF08E" modified="2021-04-07" version="1">MAALGLLLRVGVAMAVVVAVMWVAARLLQRRVGPSARGGQPPQVEVLARRGLSRNSSVAVVRVGGRTLILGVTDAQVSLLAETGTDTTLFDLTEAGSGTLSLEVAPPPAARTPLVESLRERTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB5</accession>
    <name>A0A7K0JXB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001086">
        <property type="protein sequence ID" value="MST34590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="7775" checksum="FBD788F0AFFDFC20" modified="2021-04-07" version="1" fragment="single">MGASLGEGVRSGVGVVDKAVSILDALELEPRSLSELAGATEMPRATAHRLALALERHGLVDRDAAGRFVLGPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW1</accession>
    <name>A0A7K0JXW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001224">
        <property type="protein sequence ID" value="MST34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="23389" checksum="16328094CC0464B4" modified="2021-04-07" version="1">MIRVILADDQALVRAGFRVLLGAADDIDIVGEAGDGQTAVDLARSAGADVVLMDIRMPGVDGLEATRRIAAAPDLADLRVLILTTFEADEYVFEALRSGASGFLVKDTEPEQLLEAVRVVARGEALLSPSVTRRLIAGIAGRGAQRPLDAAPLSVLTDREREVLALVATGMNNDEIADALYMSPLTAKTHVSRAMTKLGARDRAQLVVIAYETGLVSPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY26</accession>
    <name>A0A7K0JY26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_19320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001263">
        <property type="protein sequence ID" value="MST34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="292" mass="30433" checksum="F03E8D5587BA970E" modified="2021-04-07" version="1">RPNVTSDAAALCLKAGNAALLRGSSAAIRSNQAIAAALRAACAGSGLPADAVQLVEDTSRESATAFMRLRGVIDCLVPRGGPSLIAAVIEHASVPYVIDGDGNCHVYVDRAADLGMAVELVVNGKTQRPGVCNATESLLVHADVAGAFLPRVAAALPGVELRGDEESRRIVGGERVLAASADDWGREYLDLCLSVKVVADLDEAVAHIGRYGSGHTEAIVTGDRAAARRFQREVDAAVVAVNASTRFTDGEQFGFGAEIGISTQKLHARGPMGLRALTTTKYLVDGEGHVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY77</accession>
    <name>A0A7K0JY77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001251">
        <property type="protein sequence ID" value="MST34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10409" checksum="6AFA388D3DE3F214" modified="2021-04-07" version="1" fragment="single">MTEPHQDHDHDHDHSHGHGHDHDHHGGLRGVLEGLFRPHSHDPADSVDDAVASSREGMRTLKVSLGGLAATAVVQLAILILSGSVALLADTIHNFADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA5</accession>
    <name>A0A7K0JYA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001046">
        <property type="protein sequence ID" value="MST34509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="3">
        <location>
            <begin position="127"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="25561" checksum="77EB59F9E354F053" modified="2021-04-07" version="1" fragment="single">GGQPGAGGPPGAGGRAEELGRPRRLHLVGIGGAGMSGIATILATMGHTVTGSDRRDSPTVQRLRSHGITVAVGHDATLVASAELVGASSAVPPSNPELVEARRLGIPVLWRVELLAALCGLRRTLAVAGTKGKSTTTAMVAHILEVAGERPSFLVGGDLPGVDGGARWVGDSPWFVVEADESDGTFLALPTEAVVVTNVEADHLDQYGSMAALREAFTTFARGASGPRIVGADSPDALVVARELEAAGDAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA8</accession>
    <name>A0A7K0JYA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001314">
        <property type="protein sequence ID" value="MST34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="3">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="180" mass="19226" checksum="AC8C3451832BD25C" modified="2021-04-07" version="1" fragment="single">MIPAGDGIRLQKLLAQVGLGSRRVCDELIADGRVTVNDEVADLGRRVDPEVDRITVDGVPVSVRPGLVHYLLNKPAGVVSTASDPEGRPTVVGLVPAEPRVHPVGRLDADTEGLLLLTNDGDLTHRLTHPRYGVEKEYLAHVDGGALRPNQLRQLREGVALDDGVTAPARVSQPSPGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH6</accession>
    <name>A0A7K0JYH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">(2R,3S)-2-methylisocitrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.33</ecNumber>
            <ecNumber evidence="8">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Probable 2-methyl-cis-aconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">leuC</name>
        <name evidence="19" type="ORF">GHK86_17910</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="7"/>
    <dbReference type="EC" id="4.2.1.99" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001086">
        <property type="protein sequence ID" value="MST34589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="18">
        <location>
            <begin position="3"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MST34589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="379" mass="40064" checksum="CDCFEFC52107D593" modified="2021-04-07" version="1" fragment="single">MAEKVWDRHVVHTAPGEPDLLYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTVATADHNVPTTPGPVEDPVSAQQLDVLTRNCEEFGIRLYPRGHARQGIVHVIGPELGLTQPGMTIVCGDSHTSTHGAVGALAFGIGTSEVEHVLATQTLPQQRAKTMQVVVDGELPPGVTAKDVVLAVIGRIGTGGGIGHVIEYRGSAIRSLSMEGRMTVCNMSIEAGARAGMVAPDDTTFAYLEGRPAAPTGRAWEQALDEWRALATDDGASFDRTVTIDAAGLRPHVTWGTNPGQVVALDDAVPDPDSFDDPGRAETARRALAYMGLTAGTPMREVRVDTVFLGSCTNSRIEDLRAAAAVLEGRRVAGGVRALAVPGSGQVKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ9</accession>
    <name>A0A7K0JYJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">GHK86_20170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001375">
        <property type="protein sequence ID" value="MST35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="12513" checksum="7E4048C65A8A609C" modified="2021-04-07" version="1">MPPTQRIRIRLKAYDHEILDQSTKKIVETVLRTQAKVRGPVPLPTEKNRYTVIRSPHKYKDSREHFEMRVHKRLLDIVEHTPKTVDSLQRIELPAGVDIEIKIQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR6</accession>
    <name>A0A7K0JYR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fumC</name>
        <name evidence="5" type="ORF">GHK86_20515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001431">
        <property type="protein sequence ID" value="MST35101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="12"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="404"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="460" mass="48885" checksum="95E7D74DBF6016C8" modified="2021-04-07" version="1">MTDYRVEHDSMGEVRVPVDAKWQAQTQRAVENFPISGTTVERSLIAALAAIKGAAAAENARLKIVERAVAEAIRAAAQEVADGRWDGEFPIDVFQTGSGTSTNMNMNEVLATLASERLGRSVHPNDHVNASQSSNDTFPSAIHLAATQEITRSLVPALEHLAKALRRKSRAWKSVVKSGRTHLMDATPVTLGQEFGGYAAAVEHGVERLQAALPRVGELPLGGTAVGTGINAPKGFARAVIRRLSDELDLPLSEARDHFEAQGARDALVEASGVLRTIAVSLYKCATDLRWMGSGPRTGLAEIRIPDLQPGSSIMPGKVNPVIPEAVSQVVAQVIGNDAAVAFGGAAGNFELNVMLPVIGRNLLESIRLLANVSRVFADRCVAGIEADEERCRTYALSSPSIGTALNPSIGYEEAAKVIKASLAEGKDLRTVVLERGLLSAEEVDKVLDVEAMTRGGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU2</accession>
    <name>A0A7K0JYU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001455">
        <property type="protein sequence ID" value="MST35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIIM" evidence="1">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="17025" checksum="73AC61D309FC9B0A" modified="2021-04-07" version="1">MGSTAADQLTRRILAGMGLQVAEAKTDICWVGDGFEFLGFRITGRSVQPRPAALERFKNRVRAATRRQAPMSLARMIENLNPLLRGWGSYFAVGTVAHLYVDLDKWIRTRLRSKVRGSKARQISNRKMPNRVLAGYGLVSLVELRQARLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ9</accession>
    <name>A0A7K0JYZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_20935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001499">
        <property type="protein sequence ID" value="MST35185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="21232" checksum="4C6DFB99CF621F91" modified="2021-04-07" version="1">MPPSFADVSDAALVVAVGRYHESALAEVYRRHGGAVYGLARRLVHEPAVAEDIVQEVFLRLWNEPERYDPERGSLRSFLLAQTHGRSVDRLRADHARRGREEREARAAATAGYDLEREVIDYTVGEAVREAVAALPEGERQAIELAYFGGRTYREVATALGEPEGTIKSRIRTGLRRMRGSLSEAGVASGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ30</accession>
    <name>A0A7K0JZ30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="6" type="ORF">GHK86_20720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001465">
        <property type="protein sequence ID" value="MST35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="5">
        <location>
            <begin position="67"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="25970" checksum="D95C2933FD01BF1A" modified="2021-04-07" version="1">MTPLDPTGRPSSAGSATATGPVLPPGAGLGDEELAELDAAFERQPPGAIIRWAVEQFHPYLCLTASMTDAVLIDLAVAAEPSIEVVFIDTRYHFPETLETVTAIRRRYGLNLRIMTVPPQARPLWQADPVNCCSAAKVEQLDRALQGKLAWMSGLRRAEAPTRAGAPIVARDARGLVKVNPLATWSDEDVAGYIADHDIPVNPLLERGYLSIGCAPCTQPVAAGADPRSGRWAGSGKTECGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ34</accession>
    <name>A0A7K0JZ34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001516">
        <property type="protein sequence ID" value="MST35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="230" mass="24676" checksum="1D735DAFBAB50E8F" modified="2021-04-07" version="1">MPDAPPVLLVHGFASSFERNWREPGWVDILREEGREVIGVDLPGHGDAPKPSDPAAYTELDVAVEASLPDRPVDAVGFSLGGWVVLRLASRFPERFARIVVGGVGENLFRDEDPEPLARAVETGEAPEGAPEPARAFAQFGRAPGNDRTALAAVLRGTSERLDPVALARVTCPVLVVLGDRDFAGPPQPLVDALPDARLVEIRGLDHFATPKDVRFLDATLEFLSRPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF4</accession>
    <name>A0A7K0JZF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_21790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001653">
        <property type="protein sequence ID" value="MST35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="18247" checksum="C6B274392A6B1D34" modified="2021-04-07" version="1" fragment="single">AARRRAGLPDGVVVTSAIEHAAVRNAAAGAGVPLREAPVGADGVLDLDALAGALDPDVALVSLMLVNNEVGTVQPLAAAADLVRRRAPGALVHTDAVQALTWLDLREEAACADLVSISAHKFGGPQGVGALVVREGTPLVAVAEGGGQERERRGGTHNVAGIVGMAAAAVATDRDRATAAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0D1</accession>
    <name>A0A7K0K0D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001533">
        <property type="protein sequence ID" value="MST35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="273" mass="30347" checksum="FED0E4E9C9651693" modified="2021-04-07" version="1">MLTIGDFARLGQVSPRMLRHYDEIDLLRPDRVDPVTGYRLYDVRQLGRLHRIVALRDMGFGLEQIAQVLSEEVSVDELRGMLRLRRAQIARTVEEEQGRLRRVEAHLRALEWSDTVELQDVVVKQTVPVRVARATATGLSHADIGAAFGRLLPRVLAHLEAAGVAPGLSVGVYEDQGGSVPEGELVLHAGFAIGDRDLPDGDDVHVVDLPVVEVAAATYRGPNDGIVAAWEALVRWVDDSGYRLVGDCRELYHEWDDTDPSRNVMELQQPIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0L4</accession>
    <name>A0A7K0K0L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_21585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001606">
        <property type="protein sequence ID" value="MST35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="63"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="18203" checksum="8BBBED2A470BA626" modified="2021-04-07" version="1" fragment="single">MSTALACRPAPATPPAPRHLALVPDAGADPGPDRGSAGVAGPALDGLWEVYKATGDRTVRAQLIAGYQPLVRAVAARLSAGLPRMVDEADLVGYGTFGLIDAVERFDPGLGHAFEGYAMARIRGAIIDELRGLDWVPRSVRRKARELDRAAARLESRLGRQPTDGEVAAEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMH1</accession>
    <name>A0A7K0JMH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoadipate enol-lactonase</fullName>
            <ecNumber evidence="3">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcaD</name>
        <name evidence="3" type="ORF">GHK86_00255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.24" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042952">
        <property type="term" value="P:beta-ketoadipate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026968">
        <property type="entry name" value="PcaD/CatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02427">
        <property type="entry name" value="protocat_pcaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="286"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="374" mass="38889" checksum="279DDB315D5AA404" modified="2021-04-07" version="1">MIPSHRVDGPPGAPVLVLSNSLGASSAMWDAQVPVLTTRFRVVRYEQRGHGGSPAPAPGPYTIADLGTDLVELLDHLGVERAALCGVSLGGMVALWVAVHHPQRVDGLVLACTAAELGPPEGWAERAATVRAASPSVLAETLVGRWFTPGFVQRRPEVAAAVAAMLAADDPEGYAGCCEAIGAMDQRPDLGRVAAPTLVIAGADDPVTPPARAVELQAGIPGASLLVLAGASHLANIEQAAAFTQAVVDHLAGTIVERGDAMRRRVLGDAHVDRSAADASPLGAPFTDFITRTAWGDVWTRPALDLRTRSCITVAALSALGRLEELELHVRGARRNGLADEEIAEVILHTAVYAGVPAANAALRVARRVLEADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMP6</accession>
    <name>A0A7K0JMP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">GHK86_00535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="11019" checksum="EAD8E818C9BB0D87" modified="2021-04-07" version="1">MKLKKGDRVQVLSGKERGKTGEITRVLPETNRVIVKGVNVAKKHQRQTSTRLKGGIIDKDMPIHASNVAIVCSKDGATRIGYRIDDDGSKHRVCVHCGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMS6</accession>
    <name>A0A7K0JMS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000016">
        <property type="protein sequence ID" value="MST31193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041359">
        <property type="entry name" value="MetOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18546">
        <property type="entry name" value="MetOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MetOD1" evidence="2">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="293"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="447" mass="46580" checksum="4EBFB2B39DC72C69" modified="2021-04-07" version="1">MIVDQLRRRAAAPERAVEAEPLVREALAVPAACLWARLDWERVQPELTVRARAERVDDPGSSLADGVWSADRPTAELAAIFDGGPAVRVSLPVARGPVVDLDLAPSRVVPEDGTAYPGAVASILAGQLESGRTMPEAAAVAGATAAGAALGAWHAEQDRSPTTAAEVADAFLAFVNRAGADFAVVEADGRRAVVANRRCPFGSGSANPEVLCRSTAALLGSLGARLNGRATVVLDESIAAGDHRCRAVLDLDGEPSRWNQRYTWPPAGPAGSRGAAVTQGFRVAISLQLPRDQLSVPLIRHMVSNTLREVGAVDDDVSAVEIAVSEAAGNVIRHSGAGDAYDVEVTIGPHLVELRVIDIGRGFDSESIQGDAPDLSAESGRGMALMHALVDQATFASAPERGTVVHLVKTLHFDEGAPARRLMLSQLAEHNAAGEDPEPGGTAAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMT0</accession>
    <name>A0A7K0JMT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AlbA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="308"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="464" mass="51241" checksum="9C91F161832CBEB9" modified="2021-04-07" version="1">MVLPLSKDVSGKGVNVDQGSLNIKEVIDLLNGDAWVRLVASGAEGTWSLRHLHAVIGSQPPAWPDHDWIYGDIALLRAKLSIDRLKDALVAEDCRRFSVGSIEVEVPEVGPQVGWRRRPSFEQHDRERLQKPTWDLRVSAAQTSQHQLNRSGYLVGRSCPSFPDLQYAFRAFFEGDFSLNGGMSLPSELMVIRVINDEGWIGPIHVTPTHIDVQVDGRDLLGASLELYSTDQRTTTDLNSPNTVTFELPGGLPDTNVWLWLKKDGRWLDYRALYRPWATPDQLEAAGVKIDLPVDPLSTIEALVSGGEGPQVEFKRSLPETKSKDRNPYKTIAAFATMEGGWIVFGVDRDELTVVGLEVDDINGERDRLANLIRARVNPTPPFEATPYVIDGKQIMVLRVDSGVSPPYGIAVDPDAKDRPEYFVRRGASTYPAWPADLREAVMSRQPPAGFPNGMGGLGGAFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMY8</accession>
    <name>A0A7K0JMY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="13916" checksum="073C30A2DFBEE813" modified="2021-04-07" version="1">MATSDDEVRLVVPAMPEYLRLARVTAAGLASRLGFTFDEVEDLRLAIDELCYGLTGSGGRDGTVAIRYVLGADSLVIEGEGQFRSESKVALSELSEVILQALVDEHDLHDGVGGPSFRLVKRRHDTSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN61</accession>
    <name>A0A7K0JN61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside triphosphate pyrophosphohydrolase</fullName>
            <ecNumber evidence="5">3.6.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mazG</name>
        <name evidence="5" type="ORF">GHK86_01040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000036">
        <property type="protein sequence ID" value="MST31317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11723">
        <property type="entry name" value="YabN_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035013">
        <property type="entry name" value="YabN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TP_methylase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="4">
        <location>
            <begin position="248"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="491" mass="52566" checksum="B3DA2B598FB1196A" modified="2021-04-07" version="1">MVTPVAGRIVVVGLGPGDPGLVTAATLAAVDAIPVRYLRTARHPSAHLVGKARSFDDRYEAAARIEDVYDGIVATLREEAARHGEVLYAVPGSPLVAERTVELLRAGGSGREVRVLPALSFLDLAWERLGVDPVAAGVRLVDGHRFEVEAAGAAGPLLVGQTDRRLVLSEIKLSVDGDPGPVVVLQRLGLPDEAVTEVAWSDLDRAVEPDHLTCLWIPRLAEPVAGEVARLVALTRDLRSRCDWDRAQTHASLRRHLLGEAYEVLDAIDELPSDDGWELLEEELGDLLFQIAFHAQLAGEEGRFGFADVARGIHDKLVARHPHLFGLDEDGTADSSDRSWEERKRREKGRTSVLDGIPTSLPALAGAEKLQRRAAGIGLDWEGADAVWAVVEGELAELREADEAPEGPAREAAVEAEVGDVLFSVVNLARKLGADAELALRAAAARFASRVTAVEGLAAEQGLDQAALAALDPDAADRLWQEAKRRAGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG3</accession>
    <name>A0A7K0JNG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein subunit beta/FixA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="21192" checksum="2B116126C4B51292" modified="2021-04-07" version="1" fragment="single">MRIIVPVKQLPDLVEDLELDPSGADIDREYLKFVANEWDEQALEEALLIKEAVGAEVVVVGLDEPDIDQTLYTAIARGADSAVKLTDAGEGWLSTHARAEILAAWLSGQTYDLVITGVQAADDLDGQLAAVLAGRLGLPHAAVVVSLEVKDGTVVVSQELGGGAVGESDVPMPAVIGMQTARQAPRYAPITRIRQAMQAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG9</accession>
    <name>A0A7K0JNG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="26209" checksum="38F2604A89BD2D85" modified="2021-04-07" version="1">MEELAGQVALVTGAGAGLGRAIALEMARAGATVATVDIHEDAAGETAALIAGEGGTATPYVTDVAVREEVDATWDAAARDLGRLDIVVNNAGVSFVGPTILDTTDEAWHKSIDVMQHGVFYGMRAAARHMLPQRSGSVVTISSIRGFSSNPGRIAYCAAKAAALMMTRVAAAEWAPFGVRANAIAPGVQRTPMWEQDAARGAVDEPAILRVLPAGRLGDPAEVGRLAVFLSSRDAAYINGSCVTIDGALTAVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU6</accession>
    <name>A0A7K0JNU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1932 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_02685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1932" evidence="3">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="28317" checksum="1CCA26424E6438F1" modified="2021-04-07" version="1">MDATTAHASSGAAGPDRSPTTPPVIAVLGLGEAGSLIARDLLAAGAVVRAYDPVVSPAAGLVACAGDAEATAGADLVLSLNSAHDALDALLAGLPSLAPDAIWADLNTGSPRLKQQLSDAAAERDRAFVDIALMAPVPGRGLRTPMLASGPGASGYAEVMGPLGAHVDVLGEAAGLAATRKLLRSVFYKGMAAAVVEALTAAERAGQDGWLRAHLAEELSAETVDRLERGTYRHARRRRDEMRAASELLEDLGVAPHISSASGALLADLTDSGKSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP16</accession>
    <name>A0A7K0JP16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000121">
        <property type="protein sequence ID" value="MST31706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029609509" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="19827" checksum="7EAA86363643FE2D" modified="2021-04-07" version="1">MLKRIAVATAIGASMFGLAGVGASSLATGTNNGTVQQSNALTATCQSGLNSTLDFSNVVTKDDVTAARVFQQSVEPKCSGEMLQIALKMNNGAVVYSNKVWIPTSNVTTAQQEAFLLGGSTNLSEFGYAVYGEDLYPQFPQGVCANAVVSTVVTVADQINSPGSNTSSAVDGTLPTCTGHDAFFTNTSKPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP76</accession>
    <name>A0A7K0JP76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000117">
        <property type="protein sequence ID" value="MST31691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="25676" checksum="EB9B0327DCEF8A0F" modified="2021-04-07" version="1">MSVTTRWDTIGAGEQGFDAYCALPEAGSGPGLLVFQEIFGVNDNMRTLAGRLAEAGYVALVPDMFWRIERRFERSDDSGMADAFAVSQRFDLTTARGDVQAAHAHLLGLPECTGRVGAIGFCLGGTLAFVAGTSSRVDGRGPDAVVAYYGSGITDLLGEASRLEAPTLLHYGTRDEYIPADEIALVETALAGRPDVELHRYDAGHAFSNEDSSRFYDPAAAAEAWPRTLAFLRRYLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP86</accession>
    <name>A0A7K0JP86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000119">
        <property type="protein sequence ID" value="MST31701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="34"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="18787" checksum="C3910DD0E36EDC33" modified="2021-04-07" version="1">MAAGGWEAVVMWPRHRLEDPVAVDGIDAADGAPFRRVLVPVESLSQSASALSLAARIGAATAGKLRLVHVRSWDPPMPRGGGRFYPESSEEATAILEAAMTFAWSRGVEASGVVVEAQSSSMGMAILAESAGWGADVIVLPSRPRRWLGLGLWEKAARQIERRAVCPVLLVYPGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA8</accession>
    <name>A0A7K0JPA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">GHK86_01380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000055">
        <property type="protein sequence ID" value="MST31384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="11070" checksum="CAAA51DCD6D410F9" modified="2021-04-07" version="1">MYAVIKTGGKQERVEEGQTLAVELLGAETGADVRFTPILVVDGETVLSKPDELGQASVSARVVGTANGPKIRGLKYKPKARARTHWGHRQHYTTIEITGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB6</accession>
    <name>A0A7K0JPB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000059">
        <property type="protein sequence ID" value="MST31399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="207" mass="21269" checksum="16D255255BF088CF" modified="2021-04-07" version="1" fragment="single">MTGLSWLTQPTAQPNVPPARGPLVHSTRFWVVLAPTALVAGAAATGLKLLLRVVEHAAFSYHGGELIRAAASTSAVHRVATLAVAGALAAGLWWGLRRATGTIGGQMTEAIWSGEGRMATAPTLFSAGLSMTVIAMGASMGRESPPKEAAAALAERLARWGRLSDEERVLLMACAAGGAWAAVYNIPFAGAAFVAEVLMGSLALPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS2</accession>
    <name>A0A7K0JPS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="2">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12913" checksum="24C82CDF48994841" modified="2021-04-07" version="1">MTHPVESLDDVVHQRTRLGILSVLAEVHRAQFRYLAETLGATDGNLSRHLQVLEHAGYVTIDKGYEGRRPRTWVHITPDGRRAFDHEIRTLRQLTTPTAPTPDPPSSVAQDPKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT1</accession>
    <name>A0A7K0JPT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000177">
        <property type="protein sequence ID" value="MST31933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="171"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="510" mass="54165" checksum="CEBDC506E5A21212" modified="2021-04-07" version="1">MSSPSPSSARPPGCIVWEGDQFSDHSLATVNRGICSHLLRAGVDLRLVAGDAPTGEVPAGALRSLLPAVGPPRAGTPVAAVVRQAWPPLLQPPGAGRWVQAQPWEFGGIPRRWIDGLAAADDVWVHSSWVRDCYIASGRDPDRVHVVPAGVDAGFFRPDGARRPYGRGRSFRFLFVGGLIYRKGIDVLVNAYLRAFGPRDDVCLVIKGFGSAGIYAGNTRNQLLQLAARTDLPAIEIIDEEMDAEGMASLYRSCDALVHPYRGEGFALPVIEAMASCLPVLTTGYGAVLDFADEDTARFLPARLVPAPLIEGELGPPAALSYFLAEPDADALVEALRSLPADESRFERARLARARVSKAFSWEAAASVALERLLELTDGSRGHRAPAEVTDLLLPVEPASTNWEGVVRDFVSTFRGSDPIRLRLGVRGGPGDARALGAATRRVIVGAERNPATCAAIEVALLDDRSQADLEASGALVLDESRGGLRAAGYGLPPALRARLGAGELSSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ18</accession>
    <name>A0A7K0JQ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="14343" checksum="13FC3A06407DDE55" modified="2021-04-07" version="1">MGHHQASLAKVRKLRALAQATVAEAMGMDQSEISRLERRTDLLLSTLRRFVNATGGSSTSSLLTPTATSSCWSARPCPKSPVPSPCWTPGPCHIRATTVGQTRSRPGAGGQVERASDLPERTNALVSGGCDSPFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ26</accession>
    <name>A0A7K0JQ26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000197">
        <property type="protein sequence ID" value="MST32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="231" mass="24507" checksum="C9C7BDD3420B23F6" modified="2021-04-07" version="1">MGLQQQDDRHQPVGAHPTRIFPETGQEMAGSGLHALPMTTTDHRSALHRSYEHAATIVAGVRPEQLGLPTPCPDYDVAALVDHLVGAGHRAVALAGGGAPGGDEFPHVELAEAVEQLRAAGKESASAWADDAALERTVTMPWGETYTGRTLVDMYLGELAAHTWDLARATGQLDRIDGSLGTPALEAARSMLKPEYRNVGGPGNPFGAEVPAPEGATDYERFVAFTGRDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ51</accession>
    <name>A0A7K0JQ51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GHK86_05005</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="WJHE01000209">
        <property type="protein sequence ID" value="MST32085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029849960" description="NAD(P) transhydrogenase subunit beta" evidence="17">
        <location>
            <begin position="26"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="18">
        <location>
            <begin position="2"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MST32085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="459" mass="46241" checksum="8D73C4025641E4EF" modified="2021-04-07" version="1">MNLAFLFAAVCFVLGLHFMNSPATARRGNQVSAGGMVVAVAAAFALVADGGTMTAARWLVLLCGALVGAGVGLWAARSVLMTAMPQLVSLFNAVGGGAACMIAIADYAHNIHQGSGTAVATVLDVLIGSITFAGSLVAAAKLQGYASQPVRFPGGRLLNAVVAVVAVGSAAAVVARVESLPVLLVTLVAALGVGLLMVLPIGGADMPVVISLLNAFTGTAVAMAGFVLNNAILTVAGALVGASGAILTKLMADAMNRSVPSIMAGGFGTGAVGVEASAAGGGTVRSVQVDDAALQLAYAEKVIIVPGYGLAAAQAQHELRELASVLEERGVDVAYAIHPVAGRMPGHMNVLLAEANVPYDQLKEMDEVNPEFPRADVALVVGANDVTNPAARRPGNAVSGMPILDVDQAKSVIVIKRSMASGYAGIDNELYTDPKTAMFFSDAKKGLASLTAAAKSLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ76</accession>
    <name>A0A7K0JQ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydantoinase/oxoprolinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000212">
        <property type="protein sequence ID" value="MST32100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="205"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="345" mass="36231" checksum="B957EB39E1F0087B" modified="2021-04-07" version="1" fragment="single">MTYRLGVDVGGTFTDVLLIDETTGVTHRAKTPSTPADQSRGVLDGVVKACGLARIEPSEVAQFLHGTTVATNAILEGKGARVGLVTTRGFRQVLQVARSFVPGGLAGWITWPKPTPLAHLEDTVEIPERVDTRGRVLVELDEDAARAALGHLREQGVEALTIAFVNAFANPDHERRVAELAAKELPGVPVSLSSEILPEIREYERTITTVANSYVRPVVGRYLESLERQLRDGGVGSPVHVLRSDGGLASIATAEVAPVSLLMSGPAGGVAGAVWAAGQAGYRNLLTFDMGGTSTDVALVEDGKPRIGRDTTVGDLTVRASSVDVRTVGAGGGSIAHVPELTRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ98</accession>
    <name>A0A7K0JQ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_03250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000128">
        <property type="protein sequence ID" value="MST31744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="895" mass="94560" checksum="BB82F0C6B22E6BC9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA2</accession>
    <name>A0A7K0JQA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISAzo13 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000206">
        <property type="protein sequence ID" value="MST32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011518">
        <property type="entry name" value="Transposase_36"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07592">
        <property type="entry name" value="DDE_Tnp_ISAZ013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029529827" evidence="1">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="388" mass="42586" checksum="59E7620D898CC356" modified="2021-04-07" version="1">MNERQRRVVAGAMAKALGRGGKTAVAAASGMSRNTVIKAVEEIEVGIEPSERLRAIGGGDKPATEKQPGLLEALDRLVGPATRGDPMSPLRWTTKSAARLADELVGEGYQIAARSVLRLLHQLGYSLQANAKVVEGATHPDRDGQFAYLNNLAGEFLAAGDPVISVDTKKKELIGNYANGGREWERKGEPVRVNVHDFADRALGERAKAIPYGIYDLANNEGWVSVGDSADTAAFSVEAIRRWWNCQGQRRFPHARRLLITADAGGSNGYRLRAWKTELARLATETGLTITVCHYPPGTSKWNRIEHRLFSFITINWRGQPLTTLRTIIELISATTTSTGLTVHAEHDPGTYPKKIRITDAELAAVPLTRHQWHGEWNYTITAQPNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB2</accession>
    <name>A0A7K0JQB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_05015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000209">
        <property type="protein sequence ID" value="MST32087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="444" mass="48279" checksum="07B143597AB2225B" modified="2021-04-07" version="1">MSDPYAITLPLADPPSPHFTGTDVGLIAAVVLLIVLTGFLALSETALTRMSRVKAMSLVEERRRGARTLLRLVERTERVLPVVLFALEVATLVAATLVGVVASDLFGAVGVLIATIFEILVIFVVAELAPKTWAVQHSERAALLAAPVIRFLYAIPPLRWVTRGLIRVANALLPGKGMSDGPYTSDEMIRAIADTAAEEEVIETEERTLIHSIIDFGDTVVRDVMIPRPDMVAVESRAKVADVVDIAINAGYSRIPAWGQGIDDIVGIVFVKDLLRAVRSDEGDEPVSAVLREAHFTPESKRVSELMREMQREKFHIAIVVDEFGGTAGVVTLEDLIEELVGEISDEYDVEATGVERLEDGTVVVNARMPIDEVNDLLPEPGLPEGDWDTVGGLVYSEAGHVPIEGEEVEVEGHRLRAEAVSGRRIGRVRIEPAPPREHEPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG7</accession>
    <name>A0A7K0JQG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_03665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000149">
        <property type="protein sequence ID" value="MST31824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="244"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="472" mass="49801" checksum="2D83E8A006DC5DCE" modified="2021-04-07" version="1">MTRRLLASYLGLAVLILLVLEVPFGFIATRHELDSARSAASRDATEIAVGSTETMETGSRAALKALVQDYFARTGAELAVVGSNGRVLAEIDADRDDDVALQAQMVHAALAGRSQSRIVHDEGHPDAVAAVPIGPTARPLGAVLFTVPVGAFTDHVQDIWLALAGFAAAVLVLTTLVGLWLANSLARPLAELERAVARLGGGDLAARASADLKPAEMRTLAEAFNRMAERLEELVSAQSRFVADASHQLRSPLTALRLRLENLEAELDPVTGEAMAAVGREVQRLSRLVDGLLAISRADQAALDVEIVDVAGVIEERCDAWAALAAERRIALERSADRSLRSTTGLLVPGDLDQVLDNLLANALDAAPGDSTIEVRLEPAAKRGRLVVHVLDEGPGMSPADRVRAFDRFWQGPGSRGGHSGLGLAIVQQLVHRNGGEVALEEAPGGGLDAVVTLRAATDRTSATSRLRAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL2</accession>
    <name>A0A7K0JQL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsG</name>
        <name evidence="10" type="ORF">GHK86_05740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000249">
        <property type="protein sequence ID" value="MST32226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="17686" checksum="998DC711C0A62F1B" modified="2021-04-07" version="1">MPRKGPAPRRDLLPDPIYRSILVTQLVNKVLVRGKRSLAEGIVYDALDQIKEKTGSEPIATLKRAVDNTKPQLEVRSRRVGGATYQVPVDVRPRRATTLSIRWLVGYSRQRREKTMADKLAAELLDASNGVGNAVKRREDLHKMAESNKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN9</accession>
    <name>A0A7K0JQN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_05920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="29293" checksum="95196D1EBFADDBC5" modified="2021-04-07" version="1">MILAGLGSALLMAVGFVVQQHTAEQAPSSERLRPKLLLDLLRRPIWILGIATMVVGQLLGALALDHGTLTLVEPLMAANVLFALPLAAAWHRKRLGRREWVGAVVLMVGLGVFVVAANPGSARRVRVGADAWLTALLGVAAIVGLAVVLSRRFRNAARQATLIAVGAGALYGLQDALTQRTLELGMTPADLFGSWQPYLLVATAVVGLLLAQSAYQAAPIWASQPAMAATEPVTGIALGAGLFAQGLRLSVVPLAFEIAGIAAMIAGIVLVAGSSVVTAPASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR9</accession>
    <name>A0A7K0JQR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_05935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="128"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="436"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="710" mass="73882" checksum="DCE6EFF0B2A9E767" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT0</accession>
    <name>A0A7K0JQT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lipB</name>
        <name evidence="11" type="ORF">GHK86_04280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000180">
        <property type="protein sequence ID" value="MST31944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25559" checksum="83DE8FC70F9A90FB" modified="2021-04-07" version="1" fragment="single">MLRARWLGRVRYGDALALQHGLWADGADDWLLLLEHPHVYTLGVRADPAHVLVDPASVGAELVETDRGGDVTYHGPGQLVGYPIRSVAMGPGAVPRYVHAVEQVVIDALEALGLPGASRLEGYPGVWVGVEEGAPRKICAIGVRLSRGRSMHGFALNVAPDLAYFGHIVPCGISDKPVTSLAAEGVDVSMRAVVDAVVAAASRRFGYERVDRRDVAWRVPAADLAPFTRGEGPGVPVAAGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW7</accession>
    <name>A0A7K0JQW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000268">
        <property type="protein sequence ID" value="MST32311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="49"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="34296" checksum="6D117D971A703160" modified="2021-04-07" version="1" fragment="single">MPDQLVTGGDILTMAGGPSPEAIAVRGGRIAAVGSRDHCAGVLGARYDTVELGGATLLPGFVDAHCHPLMLGQSQTWVDCTPERAPSIDDIVGALGHRAGLRPGAPVRGFGYHQGRLSDGRHPDRHDLDRVTVEQPVMLMHASGHGIVVNSHLLDAIGVDDAMPDPPGGVIHRDAAGHATGLLWDAATDLITGEGGVKITNHGPNFHLPEPMADLLEALDLAQELFLAKGVTSVCDAQVSQREMTVWLAARDAGRLRVRAGMLVLSSLLDEVLRLGLHSTLGDDQLAFLGIKCYSDGSLTSYNAAIDAGYAFDPCHHGHEYHAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ6</accession>
    <name>A0A7K0JQZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_06295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000273">
        <property type="protein sequence ID" value="MST32333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="30149" checksum="B95393D51A1D1B8B" modified="2021-04-07" version="1" fragment="single">MPGRLPRGGGPMANGGPTPTARAQIRRDISEYHRSRTPATRDRIVAAYQGLAYSLAARFAQRGEELDDLNQVALIGLLKAIDRFDPDRGAELTTFATATILGELKRHLRDRGWSVRLPRRIHDLHLSAQQCIDELTQELGRSPTLQEIAERMQVPIDDVVEALDAGGLRHNTSLEASTAGGEEHALTSRLGARDPRLAEIDGKLELSPLLARLPERQRHILELRFVVGCSQTEIASLVGVSQMQVSRLLARSLGDRPAGSSPAARLSTGRRPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR52</accession>
    <name>A0A7K0JR52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="23000" checksum="32CD15C4D0739153" modified="2021-04-07" version="1">MSSTLRRRVGALGALGALALGVAGCGAHYGFDGPLRSTGGKGNLDEMVQEDIAYHTTIDFTDQVQNYGHGPVQLLAVKPIDIPGLRPPKLAHLAVLHSPDIFDGFRGWPPRSLNERLSRHVMAVPRYGQLEKLDGFTVPPGVPGHPVSIRRAVAEVVVGIQLPPGLQAAGLAGLVVTYRAGNSTYHSAAWTAMVLEHHQKGPSADQVFARMKRIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA2</accession>
    <name>A0A7K0JRA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWA containing CoxE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000303">
        <property type="protein sequence ID" value="MST32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="496" mass="51467" checksum="8FF1B1886CB3F65E" modified="2021-04-07" version="1" fragment="single">MTLLRRDARPFEVSLGESPDRMALLAGLGVVLGFVGGLAAFVVVRLVGLISNLALLHRVGFHLPDLRHYHPGPSLIAVAVAGGLVVAALARWTPVIKGHGIPESLEAIILRESRIRPRVVVAKPLSAAVAMGTGGPFGAEGPIIVTGGCTGSLLGQLIPVSAAERRILLATGAAAGMSGVFATPVAAVLLAFELLLFERSLRSLLPLLLGCGIATEIHDVLLGGRPLFAAPGVHGVSGEQLPLFLVVGLASGALAVVLNKGLFFFEDLFRRSPVPPAWHPVVGSLAFALIGLAVPGSLSVGYWAITDAVNGRFLIGAAAVLFAGKLASWWIALASNTSGGTLAPMFLIGATMGEAIGIGFAHLFPALHIQPAAFALVAMGATFGTGSRALLTGGVFALEVTGAFHLVVPMFIALGVAELVVERFLDDRIMTDKLVRRGFRVDFDAQVDPFRTAVAAQAMDALPAGPLDADLPVIPGDAYLRDALAVFLRQPVEQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA8</accession>
    <name>A0A7K0JRA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="6" type="ORF">GHK86_06880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000293">
        <property type="protein sequence ID" value="MST32443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="145" mass="15321" checksum="053C733FEED87763" modified="2021-04-07" version="1">MLRVPLVALDPDLPLPRYALPGDAGADLVARHGAVVAPRGGRVVVPTGVKVAIPEGYAGLLLPRSGLAFRHGVTLANSPGLIDAGYRDELCAIVVNTDASEAYEIRRGDRIAQLVVVPAERAEWDVVEELEPSVRANGRFGHTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD8</accession>
    <name>A0A7K0JRD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000225">
        <property type="protein sequence ID" value="MST32154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="20830" checksum="971EBD081745E99A" modified="2021-04-07" version="1" fragment="single">MARDQGECRRVELPGGRSLTVRPMVPADADGLVALFAAFGEDDLYARFFTAHPPPVQLVERMVRVGGRGGAGLVAVVGAARGEVVAEVSYEPLGNGDGELGIAVARAWRGWLGPYLLDALLAAAARAGVGNLEADVLVANRPMLALLRARGHAVIRHDEGPATVRVVVGTHGAAPSWPAGSDRPRLLVEAPGRWPAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK1</accession>
    <name>A0A7K0JRK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000335">
        <property type="protein sequence ID" value="MST32578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="75"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="19852" checksum="8245A1D2D687F871" modified="2021-04-07" version="1">MSEQSGPAVGQEAASPFPARYGSVRGPVEDVALNEAPRAAPARGGYEQTGSWVPAEEAGGRTQAIPVADGTVPVRRLIRRLDVWTVFKVSLVFYILFGLIVLVAGVVAWIVGVNLHFVRDIERAVRTLADKRKFVLHPLPVLEYAAAAIGVLALLGTVVNTVAAVLYNLISDLVGGIQTVEVLQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN9</accession>
    <name>A0A7K0JRN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000338">
        <property type="protein sequence ID" value="MST32601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029494631" evidence="2">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="16158" checksum="6CE3B34CBAEFBA61" modified="2021-04-07" version="1" fragment="single">MLVVLAALGAAVLYAVASVLQQRAAAEQPEDQSLRLGLLAGLVRRPSWLLGMVADGGGFVLQFLALAAGAIALVQPLLVLSLLFALPLGTWVSGQRLRIADLLAAAAVCGGLATFLDAGAPAAGRAFIPGRTWLALLVAGCGLALVLVLAGRRAGDRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT2</accession>
    <name>A0A7K0JRT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-propeller fold lactonase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="375" mass="39419" checksum="D3394A2EE9DC166E" modified="2021-04-07" version="1">MTAPATARTPEFIHTAVGLGPEGLALDPARRRGYVSCPRSNEVVAFDLDGGGMLGRVDVGREPIPVIYDPTGDRIFTADARSDTVSVIDAATFALLAQVPVAEYPAGLGFDEQRRKLYCGNTAGSSVTVIDVDRLEVLDHTPAALGAGSIAIDPVQGLVYCSNFMDDTITVLDADTHEARGDIRVGAAPCKVTIDAGRRRLYVANSLVATLGVVDLDTGRVVDEYPIGGAPVGIMARPVDEVVYAADRGSGELVVIDTRDGATLARLPVGNGPGDVVWAEDTGIVYVSNAGSCSVTRVADPRASDPRRAATEATQAETTDGAACAVPWATPAVAPHPLIGKPMPAFALPDMTTGEIRTIEEWQGKKYILNFFASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV8</accession>
    <name>A0A7K0JRV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_07955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="391" mass="41796" checksum="CB6769EA267D3F17" modified="2021-04-07" version="1">MSLADTVELPPELGELRATVERFARQEIAPVIAGYYEREAFPYEIVAKMGELGLFGLPFPEEYGGMGGDYLALSIALEELARVDSSVAITLEAAVGLGAMPIFRFGTEAQKQAWLPDLCAGRHLGGFGLTEPGGGSDAGGTRTTARLDEGADEWVINGSKAFITNSGTEITSLVTVTAVTGRDAGRPQISAIIVPAGTPGFTVAPGYSKVGWLASDTHELAFSDCRVPSANLLGEQGRGYAQFLRILDEGRIAIAALSTGLAQGCVDECLRYVGEREAFGHKLETSQVLQFKIADMEVRTHTARLAWLDAAHRMLAGRPFKRQAAIAKLVSSEAAMVNAREATQIFGGYGFMNETPVGRFYRDAKILEIGEGTSEVQRTLIARELGLPAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ1</accession>
    <name>A0A7K0JRZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000361">
        <property type="protein sequence ID" value="MST32683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="23697" checksum="DC0D5EBB2766B743" modified="2021-04-07" version="1" fragment="single">MNGAATLTASEVAATAGWIASVQLPDGMIPWYPGGHADPWNHVEAAMALLVGGRRAEAEAALRWLARTQLADGSWCLYYLADGVEDPRRDPNVCAYLAAGLWYHHLVTGDRRLLAELWPVVEAALGFVLRLQQPGGEVLWSMDADGTPGRYALVTSSSSILHSLRCAVAAATVLGEERPDWELAAGRLAHALAHRPERFEPKERWAMDWYYPVLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS50</accession>
    <name>A0A7K0JS50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000383">
        <property type="protein sequence ID" value="MST32765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="27348" checksum="273A13F1C256B677" modified="2021-04-07" version="1">MPRRLAVANQKGGVGKTTTAVNLGAALAELGYRVLVVDLDPQGNATTGLGINARALESSIYDVILHDVPLEDVVEPTTLRNLFVVPATIDLAGAEIELVPLFSRELRLRRALETVDGDYDYTLIDCPPSLGLLTVNGLAAASEVLVPIQCEYYALEGLGQLLRNVNLVQANLNADLDVSTIVLTMYDARTRLAEQVADEVRQHFGSRVCRNIVPRTVRLSEAPSFGQPIIVFDPSSRGAIAYRELAKEVSGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS59</accession>
    <name>A0A7K0JS59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Flagellar hook-associated protein 1</fullName>
            <shortName evidence="7">HAP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">flgK</name>
        <name evidence="10" type="ORF">GHK86_08580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000386">
        <property type="protein sequence ID" value="MST32775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01005">
        <property type="entry name" value="FLGHOOKAP1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="8">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="9">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="460" mass="45752" checksum="79117854236DE0C9" modified="2021-04-07" version="1">MSDTAGLYIGLSGIQASQQALNIIGENIANAGTPGYVEEQAVLGTIGNASVPGNDAGVAVTSIQRQSNQYLQQQVLTAQSTNQSLSAVQSALSTIQAQFPEPAGTGAFSTQLASFWSDWGSLSTNAGSTSARTALLQQGQVVAQSLNQLSAGISSVGTNAGQQLTSAVSTVNTLASQIATLNGRIVASSAGTGNPDPGLQDQRDTLVSQLSQQLNIQVTALPDGSETITAGNGTLVTGTATQQLTLSGGGASTALTWGTAGTSAAVTGGAVGGLLTVVTSTVPGQLAGLDSVASSLSNAVNTAQAQGYDLTGAKGKPFFTGSTAADLAVAITDPNQIAAASTPVPSGTSPSANIDGSNAANIADLGAGPVTFGGTTVASPTTVYGSFVADLGSAVSQVNSQVSAQSQVVSSTTTTYQNQTGVDTNQELTAMVQYQNSYQAAARYLATVQATMQDLLQTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA0</accession>
    <name>A0A7K0JSA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000397">
        <property type="protein sequence ID" value="MST32815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="30" mass="2990" checksum="7F27243F909E7BCD" modified="2021-04-07" version="1" fragment="single">MVLEGVLHVTTAGVTRTARAGEVVVVAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC5</accession>
    <name>A0A7K0JSC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000409">
        <property type="protein sequence ID" value="MST32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="18144" checksum="399C8512F976DB8B" modified="2021-04-07" version="1" fragment="single">MITPLHEGSGGLRVAVKDLVDVRGVPTTAGSRAVARRAVPAPADAACLAGLRAAMGHGRAQLVGKANLHELAAGATGVNPWFGTPVNPLDPRLVPGGSSSGSAVAVATGAADVAVGTDTAGSVRIPSACCGTVGLKTTWGRVPAGGVWPLAPSLDTVGPMARDVAVGEAGREWGPAGIGAGDHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI1</accession>
    <name>A0A7K0JSI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000322">
        <property type="protein sequence ID" value="MST32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="192"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="448" mass="48052" checksum="26485A402091A8B6" modified="2021-04-07" version="1">MSQSQDPEVVDLLQQLIRNRCVNDGSDTSGHEAASAELLAGLVARSGADIERYEPTPGRASVVARIEGSDPDAPSLCYLGHTDVVPANEDTWSRDPFGGELVDGEVWGRGAIDMLNLTAAMSLAFARLARAGWQPRGTLVLAAVADEEALGSHGAGWLVEHAPDAVTTDYLITETGGMPLAGPGGKLLPVPVAEKGSCWCRLRVHGEAGHASMPFRTDNALVTAAEVVRRLARHRPVAEIHDSWRALVDAMGWPPEVTAAMLDPERVDGALDELAAADLVLVREAHACTHTTIAPTIVHGGSKINTIPDRVDLDVDIRTLPGWGPQEVRAMIADALGDLAPRVEIVDALDDPATASRFDTPLWDRLAALAARFHPDGRLVPTLQVGATDARFFRRRGTVSYGFGMFSDRIGYDRFGAMFHGDDERIDVESLAWSAAAFEQLARDFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ4</accession>
    <name>A0A7K0JSJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000428">
        <property type="protein sequence ID" value="MST32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="49" mass="5670" checksum="12CA0AC5CF869B75" modified="2021-04-07" version="1">MAWVYVLCGVFAVLFISGFLFLTLSWRRRMRDASYSRTRRTGPRAGSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN4</accession>
    <name>A0A7K0JSN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">topA</name>
        <name evidence="15" type="ORF">GHK86_09540</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000443">
        <property type="protein sequence ID" value="MST32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="620" mass="68458" checksum="95BE7FFE2927E00B" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN9</accession>
    <name>A0A7K0JSN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000439">
        <property type="protein sequence ID" value="MST32943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="12320" checksum="6D2BCBF72263D99F" modified="2021-04-07" version="1">MTDCLFCRIVAGELPSERVLDSERTYAFRDISPAAPVHVLVVPRQHIDNAAALTAEHADLVGELLTTARAVADAEGVLERGYRLVFNVGEDALNSVPHLHLHVLGGRSMGWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS3</accession>
    <name>A0A7K0JSS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANTAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000450">
        <property type="protein sequence ID" value="MST32998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="182"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="27132" checksum="4E112FE3FA4068BC" modified="2021-04-07" version="1">MLTRQSGSRRGDGGVELRDFTRGVSFEAVDAPLMVVDTGLVIRDVNRAFLDATERCPGDLVDVPLTEAFPDNPADGRSTSGRQVRLAFEAVFERVDRYQMPMFRHDIPGAGGDRATFVRRHWTSVTTRLQDRSGRVIGAVCHAEDVTSVAEALAASSPSGLRLDAESWSHLLTALAREARGHARAARTAEQLLVALDSRVVIEEAKGFIAARSGIGVDEAFARLRQHARSTNSRLQETARAVIERGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST3</accession>
    <name>A0A7K0JST3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000452">
        <property type="protein sequence ID" value="MST33008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglycosylas" evidence="2">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="9237" checksum="4D8EE52716C61B71" modified="2021-04-07" version="1" fragment="single">SSAPSEAPAATPSQPVQAVQAVQAAPAQSYSPSGVWACIAQHESGGNPATDTGNGYYGMYQFTLGTWQAAGGTGNPAAASAAVQTAIAQRVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY3</accession>
    <name>A0A7K0JSY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1049 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="80" mass="8418" checksum="1F740121B0A72285" modified="2021-04-07" version="1">MPAGVVLAITLLFVLQNLRSTRVSFVSFSGRLPLGAALLAAAALGGLLVFTLGAMRIVQLRRIIHRSHVSSRPGRPAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT61</accession>
    <name>A0A7K0JT61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4143 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000497">
        <property type="protein sequence ID" value="MST33135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="209"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="429" mass="45833" checksum="351BDE8DAA4DB3B5" modified="2021-04-07" version="1">MVEPVTSYRTRVLDAELDALLPGLPAIAIEGPRGVGKTATALQRSAQVLRLDEPAQAQLLAADPRRLGEGPYPILIDEWQRLPVAWDLVRRAVDDDPTGGRFLLTGSAAPRTAPTHSGAGRIVTLRMRPLTLAERGVCTPTVSLAQLLESGVVPDLVAGRCGLELRDYTAEIVSGGFPGLRGGSDRAVRAALDGYLQRIVEVDLPEAGTALRRPETLRRWFAAYAAATSTTASYEAIRGAATAGEGDKPAKTTTGPYRDALERLFVLEPLNAWAPTFNHLSRLSSSPKHHLADPALAARLLGVDAGALLRGEGNQIVARDGALLGSLFESLATLVVRVCAQAAEARVLHFRSWRGEHEVDLIVERGDHRVLGLEVKLGGHVDDSDVRHLVWLRDQLGDDFLGGAVLTPGTHAYCRPDGIAVVPLGLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT78</accession>
    <name>A0A7K0JT78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="117" mass="12757" checksum="ECED6F27682D30C8" modified="2021-04-07" version="1">MPADQLVTRHHPACAVHDFHDVSRGLSDHVYKLEPYANRCSSSSTRISFYRYEVAQRRKEVTYMSKKEQAVIALALGLVAAAVAQTVVSKEAALLGLSAFEIALVGALASSLVRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT90</accession>
    <name>A0A7K0JT90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hotdog fold thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000394">
        <property type="protein sequence ID" value="MST32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="16621" checksum="64F92BD6C48EE1A7" modified="2021-04-07" version="1">MGRPPGPAARKAAAVSPPTPAAGSPERPRVPPNCDLTLGLRCVDKSEPGRTVWTMTVDERFANPVGQVQGGLLGALADSAMAASTITWARGQGLRVTAANTDLAVRFLRPAAARAGTALTCNARVRSGGRRVAFAEADIVDERGTLVATATSTYLLTLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH8</accession>
    <name>A0A7K0JTH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1205 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1205" evidence="3">
        <location>
            <begin position="167"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="2">
        <location>
            <begin position="256"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="364" mass="38494" checksum="266CAC31C177D80F" modified="2021-04-07" version="1" fragment="single">MRILFTTNAAIGHLLPMAPTAQKLIELGHAVRVACPSRFATTVTGLGLRAIACREEPVAVAVVPFPELPDPRARLAWAVMSGWPWDAREWVDTLLEHARIWHPELVVVEPVEYAGRIVAAALGIPWVLHGWGFTLPAAMSADPPSTIADLYTRLAPTRATAPALCTDLGPPSVQADDALPAARYRYRPWSQAEWPRPTCSERRRVLVTLGTYANADAAERTRLIAAAAAGLVDEVLVVLGNSDRGPATDFPPGTVALPWVDMPAAVAACDAIVHHGGAGTSWAALCAGRAAVVLPQAGDQLRNADLLSLAGAALCLQATDLNRSVISHAISRALNEPALAASAARIAAENARLPDLDRLAADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI9</accession>
    <name>A0A7K0JTI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PAC2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000537">
        <property type="protein sequence ID" value="MST33261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="32520" checksum="8C03B82706F74C1B" modified="2021-04-07" version="1">MTDPLRWHRRPELRRPLVVVAFEGWNDAGDAASLALAYLAQTWRAEPFASIDPEEFYDFTETRPQARLSDGRTRSIEWPEVELLSARIPTGPAGSTAGPGRDAILIRGVEPQLKWRTFCGLLADVARGYQAEMSVILGALLADVPHTRPVRVSGSADDAELATRLGLSHSRYEGPTGIVGVLHHALSEAGIPSASFWASVPHYVHQVPSPKAALALVERSASVLGTSVNPLELRVAADEYERQVSERVADDDDAAAYVAQLEEADDADGPSAEPSFYADPERLAEEVERFLRRHHGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL9</accession>
    <name>A0A7K0JTL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000537">
        <property type="protein sequence ID" value="MST33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21594" checksum="D61659C361ADFD8E" modified="2021-04-07" version="1">MLGRNARDRLRRPAGVVGGALDLATLQARLEDLGEAGEYARLLDRDAGAVLAGLLALSPLTTPLVTTYVERLSRPLPDLGFDGGVLATTRGYAAHMAVEAGPGAYGAVEVPVLGNLPVVRNGRPPADLLNRVIRATRRGFEHIRAVDGDVWAGLSACVTHRIHDQAGDEGPFADPVVVDALVRFGWVLRQVDLHYGQAPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN6</accession>
    <name>A0A7K0JTN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_11275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000552">
        <property type="protein sequence ID" value="MST33297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="35"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31821" checksum="464C9D9FFCA85077" modified="2021-04-07" version="1">MATTTTTPRPVSPAGAHIGTAPLRSTAAASWITLGALLLRDLVVLRKHLVEFVLRTLIQPFLLVFVFLYVFPKIGQSVGGGSAGAGDFATVLVPGVVGISVMFQGVQAVALQLAQEFGFTREIEDRVQAPCPVWLVAVAKILFGMIQGILAALIVFPIAAVVHAPGVHADFTLHWPVIVTLLPLVCLTFSSLGLLLGCVFEPRNIGLMFGFIVLPITFLGGTYYEWTRLAPVQVGGFHWLQVLTCLNPLLYANEGLRGAFTDIGHMSLFAVYPALAAFALAFLVIGIRAFRRRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU7</accession>
    <name>A0A7K0JTU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000575">
        <property type="protein sequence ID" value="MST33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="117" mass="12574" checksum="C7941CBEE98DFBD7" modified="2021-04-07" version="1" fragment="single">MSSVEVAYTALRDGIARGEHAAGSRLREEDLAATLGLSRTPVREALRRLQAEGLVEVEPRRGALVATWSADELDEIFELRALVEGYGARRAAARVADAQVGLLEELCEGMEEAVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV9</accession>
    <name>A0A7K0JTV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="26388" checksum="2AB95F4911844211" modified="2021-04-07" version="1">MREALPTRPIRAGAGGLCNRTMQGNVVTRGTSTPSVHYRCVYRTHYAADDGHPRSLAVAEHRVLAALDDWLGAVFDPDHLDSTVEAILAADQHTTTEAEPPTVTQARGAARDAEERIQRHLAALDAGLDPALVVERTKEAQADLVRARAVLAEHEATVTRPALTEDAVRAVIERYQGLAGLLEAAATPEERWALYSGLGLNLTYHRNAGSEHITGELGRGVLLRVGGGTRSVTPRFALPYLQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU23</accession>
    <name>A0A7K0JU23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydantoinase/carbamoylase family amidase</fullName>
            <ecNumber evidence="4">3.5.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_09895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.-.-" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000459">
        <property type="protein sequence ID" value="MST33029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="219"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="415" mass="43547" checksum="D8F624576664FFA5" modified="2021-04-07" version="1">MTLPAEVAAAVDGRRLGALIRDVSTLGGLPGGGLDRQTLTKPDLDARRLMVDRCCSLGAQPWRDPAGNFFLRWPATASDEPPVATGSHIDSQPGGGTLDGAYGVCAAIEVLAALASTGARLRRPVEAVIWTNEEGCRFAPGTMGSSAFADPSALDEFLAATDGSGATFGEGLAQLDAAFPDVPLRPLGVPLHAFVEAHIEQGTTLEDTANTIGIVERIQGSRWFRFQTRGAASHAGTTPRSRKRDALAAAVEVASALYGLLTEGDDALRLTIGRLEVVPGSVNVVPAAVTFTVDLRHPDTEVLDEVEARLRALARPTAGCDVQVMRTMTMSPSLFHPAVVDAVARGARSVGLPSLRMASGAFHDSLRLIRHCPTGMVFVPSRDGLSHNTAEYTDPDDLVAGARVLAHAVAELAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC3</accession>
    <name>A0A7K0JUC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="80" mass="8692" checksum="6B03073F5C026554" modified="2021-04-07" version="1">MSPKSSGPVHGSGPDGRIEIGDIREKLAELRGEVDETTDTVKPYLTYAAVGGAVLVIALAFLVGRRRGRRTSTWVEIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE1</accession>
    <name>A0A7K0JUE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_12655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000640">
        <property type="protein sequence ID" value="MST33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="36"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="363"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="396"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="629" mass="66924" checksum="416AA357B47EA2D5" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH3</accession>
    <name>A0A7K0JUH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_12715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000646">
        <property type="protein sequence ID" value="MST33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="23124" checksum="8BD46283073D397D" modified="2021-04-07" version="1">MSDPRWEAVDTYLHDALLPADPVLDATLADARAAGLPAIDVSPTQGALLQLLALAVGAERILEIGTLGGYSTIWLARALPPGGRLISLEIDPRHAEVARSNLRRAGLDDRAEVRVAPAADSLRALAASGAEPFDLVFIDADKPSNAGYFAAAMDLTRPGSIVVVDNVIRDGRVADAASTDPAVAGSRRVLEAIGAHPRVRATALQTVGLKGYDGLAIALVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI5</accession>
    <name>A0A7K0JUI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2071 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000651">
        <property type="protein sequence ID" value="MST33588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="251" mass="27746" checksum="42F4294634D2A6E1" modified="2021-04-07" version="1" fragment="single">MDRPPSPAHPPGRRLPAPVRAPLMRHRWESVAFLHWPYPVGTVQPHLPPGLAVEPWDGRAWVGLVLFRMHVELPVGRGRHVVPAFPETNLRTYVLGPDGSPGIWFWSLDATSPSAVAAARAAYGLPYCLARMTIEAAPGTVAYRSLRRWPGPRAGHDVAVRLGRQVPDREVGDFDDWLTARYTLWNRDGPFLLRTPVAHLPWSLREAEALRVEQDLTAAAGLPAPAGPPLVHWSPGVDVRIGAPRPRRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI8</accession>
    <name>A0A7K0JUI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000532">
        <property type="protein sequence ID" value="MST33234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="466" mass="49384" checksum="AC50246A99BA7E89" modified="2021-04-07" version="1" fragment="single">MTVDGPGVAALLESVPVGVVLVRDATVVGWNAAAEVLYGRRRSEAAGRPLIEVLFDPADGPAVLETLARVRAGEPWEGNARVRRADGVLLVSGFRAVPVGDDGLVAWVALDHVDQAMAEQERAVLLSAEHAARATAEEALGLVEAVVGSAPVGIAVFDLQLRYVRVNEAFAALSGLPPEEHVGSFVGEVVPLPPEVAADLRRVVTTGRHILDREVGIDTTAGGPRSFQFNFYPVQTTGGELIGAGTTVAEVTALRRAEAAREEMLAEARAAQRRLAVLSTASAALSTTMDLDEMLGRLARSLAPAEADWCLIELLGESGRFERAVASHRSAEKGRVLRATMLASPADQGGDGPIASALRSGKVQRFVRPQVQEAFARAAADRRLERFPGVEDLRSAVVVPIRSGEDPLGVLVLATEGDRLLGDDDVDLAVEVAHRAALAVRNARSYQQEHDIAENLQRGLLPASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT6</accession>
    <name>A0A7K0JUT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tryptophan-rich sensory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_13435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000697">
        <property type="protein sequence ID" value="MST33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="15922" checksum="0AD5EA71A9C1D3D6" modified="2021-04-07" version="1">MRTVGSLVLAAGGSAAAAAVGGVGARRAPQVYARLDKPPWAPPAGIFGPVWTGLYTLMGVSAFRLARRSARAALALHVAQLACNATWPLVFFSARRKRASLGVIATLDALVAAEVAVAARRDTPASWLLTPYLAWSLFATALNASVRAPSEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV5</accession>
    <name>A0A7K0JUV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000697">
        <property type="protein sequence ID" value="MST33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="26667" checksum="EC8D928DD7D94E00" modified="2021-04-07" version="1">MDTLQQRVAAVGLGALEPYGFALAGGYALQAHGLITRPSDDIDLFTDQWDTDRFTEAVQAATTAWEAEGMHVTVLRRAGTFARMALRHPSGSEVHVDLAADARRHAPATMSLGAVISETEAVGSKVAALFSRGEARDYLDVAGILASGRYRPTDLLRLGADADPGFRPAVLADALRAIDRYPDQEFTRYGLPSPDVTRLRSTMRRWAEQIDRQLSPPSQTASPSIPQRRAATPEPPQPPDPPGLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV64</accession>
    <name>A0A7K0JV64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000723">
        <property type="protein sequence ID" value="MST33782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="26803" checksum="388156353FD93C8D" modified="2021-04-07" version="1" fragment="single">AAALRRRVQLAVPERYVATSADGTEVECWAMAPADAGAGAPCPTILNIHGGPFTQYGYNFFDEFQLQVGAGFGVVYCNPRGSSGYSEAWGRAIRWPEAPDDPGSGWGGVDGDGRTYGWGDVAVFYRTNAQSRAVEEELVRRQIPYRVVGGTRFYDRREVKDVLAYLRAVANPADEVSLKRIVNVPKRGVGDTSVDRVDRWARDHGVAFGDALAHAAEAGVTGRALTGIDQVTRLLEEWRAAVAASPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF1</accession>
    <name>A0A7K0JVF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000783">
        <property type="protein sequence ID" value="MST33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="447" mass="46411" checksum="5AEE7624589AF731" modified="2021-04-07" version="1" fragment="single">MSGATPPTAPRCSLPPQPLSAARARRFVRAALAGLDEDLTATVELLTSELVTNAVLHAGTPVEVSVWAAGGRVHVGVHDATADRAVSLRPEDPDAATGRGLQLVEALASSFGVDELDGGKTVWFEVWPGLQGGPVGARRPDREGGSPAWSGSSGAGPAGLSPVVLIGLPTGLARAARRHRDALLREAHLITLGAGAPLDVSAADVRTAQSLNARIDGELDRALRALAARATPCTATLQLPSGCGADSGVLASVLDALDSSAAAGRLLTRPALPEVRRHRSWLLGQVAGQLAGEPPEAWDPATSEVAEVGGAPAAPWAERISDWDLAAVAADDDDRIVAVNDAAARLLGWSPAELRGRRLTVLVPPAWRERHVTGFTELLLSGRSRILGVPVRVPALRADGRTVEVSLLVTVEQSEQGRPLFVGRLTPTDPAWPHRTGEGAPREPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV7</accession>
    <name>A0A7K0JVV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000843">
        <property type="protein sequence ID" value="MST34086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="13675" checksum="97373A71C57477E6" modified="2021-04-07" version="1" fragment="single">MVFADRADAGRRLAARLSYLQGGPMVVLGLPRGGVPVAAEVATALGAPLDVVVVRKLGVPFQPELAMGAIGENGARVVNERVVRLAGVSAAELEAVEVRERAELERRARRFRGGRRWLPLEGRTAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW19</accession>
    <name>A0A7K0JW19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000705">
        <property type="protein sequence ID" value="MST33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="18329" checksum="A4F817FFBD640EA8" modified="2021-04-07" version="1" fragment="single">MQERPQVLAVDVGATKLAAAVVDGRGTLTWRARTPTPSTTDADELWSALADLVATAPPGPALCGIGCGGPMDVRAETVSPLNIPAWRDFPLRARVAATTGLPTWIDNDAKALALGEGVLGAAAGTGNFVSLVVSSGVGGGIVLDGRLLDGAGGNAGHLGHLVVEPGGRRCACGARGCLEAEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW43</accession>
    <name>A0A7K0JW43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chorismate mutase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000881">
        <property type="protein sequence ID" value="MST34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="174" mass="19125" checksum="BB80639CBF22BBF9" modified="2021-04-07" version="1">MPGMSLRSSSADTPPSTMGISTASPVRLSVTVMESVTAPPRGESRWLELLASYRRARFRLPTGAGCGCCQDGPMSEPTPPELAEIRRQIDAVDVELVDLLARRQRLVGQVVTFKRTHHLGVVDRHREDEMLVAIGETARERGLDPRVAQQVLRTIIDGFTLLEVEELGPDPEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW52</accession>
    <name>A0A7K0JW52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000885">
        <property type="protein sequence ID" value="MST34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="24796" checksum="AA7B760817C7938E" modified="2021-04-07" version="1">MPWNKGILRDVARRHLPLRIAHIGDSTSESLVSSNYLPDPAQRLGAQYARVGATHSIMRIQGGTSVVETIGGQPNAYQVAKNLVGSGYHGCWVVALGTNDAADVYVGSNVSFAQRIQRMMSVIGNAPVLWVNTVSLLSSGPYAESNMQRWDEALRQACSSHPDMAVFDWAALAKRSWFISDGIHYSSEGSAKRAAAIADALATAFPATGPAAGGSHCVVRAQPDWNLPSYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW56</accession>
    <name>A0A7K0JW56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000730">
        <property type="protein sequence ID" value="MST33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="6984" checksum="7117FAFD51ADEF5E" modified="2021-04-07" version="1" fragment="single">MNPDPHGGPGAVAAVVLAAGAGSRFAADGPGAPGAHKLLAEFRGRPVVRWALEAAADAGLARTWVVTGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC0</accession>
    <name>A0A7K0JWC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000906">
        <property type="protein sequence ID" value="MST34233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="24306" checksum="5C3CF7284B47A922" modified="2021-04-07" version="1">MTATTAPDFRVLRTDVPRLDAEPGIALTLLVLGADGVCCAGVDLDTGVLVRAWAPAPAERSLRPYDVIRVVVGPDPEEMPDPAAPEALYLSEPPEAIGRLQGRRVERLLRPLLHPTNAPLLSSHGPAVPFWERRRDHPSVALVEPLGPVVLRRDETYLGCRFEWQGTMRELPCLDRRLAAAMDRSGRRRMTAGPRSRLLVALTPPIDGHCHKVVEAVLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD1</accession>
    <name>A0A7K0JWD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000911">
        <property type="protein sequence ID" value="MST34243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="313" mass="34015" checksum="34CB5AF499CCF9F5" modified="2021-04-07" version="1">MTGYVLRRFGQAVVVMIIVSIVVFGILHALPGGLVRAQLGPRASAYSVHQLTIQEGLNKPLVVQYGIWAWHALQGRLGFSYKLNQSVGALLGQYLPRDLLLVGVSLLLAIAIAIPLGLWQGYRRNRPDDHALSAVMLIFYSMPSFLLGVVLIVVFNIWTNVLPSTATNFGNGPGVDFQVLVLPVLALCLGNVSYFSRYMRSSTVDNLLSDHVRTAVAKGASPGRLLRRHVLRNSLTSTVTMIGLTLPYVLSGSLIIEALFNFPGMGLLFWNAAQDRDFPVLLGVVLVVTVATVAGNLLADLGYAALDPRIRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI3</accession>
    <name>A0A7K0JWI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000767">
        <property type="protein sequence ID" value="MST33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="12329" checksum="27E0144538E1C580" modified="2021-04-07" version="1" fragment="single">QLLRGGGGTGGGSGGPGGAGGAGQLELPVWPPGTRHREVTTSDGATLHVAERGRGRSVLLLHGIALSAGVWSEQLRRLPEQGFRVVAPDLRGHGSSGIGREGLALDRVTADIEEVVQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ6</accession>
    <name>A0A7K0JWJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000771">
        <property type="protein sequence ID" value="MST33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="379" mass="38638" checksum="ED1058F26970A87D" modified="2021-04-07" version="1">MLVHHRLIAAGMALATGLSGLATTVPGRPASPSTAHPAVLHTAPRHVPVAAKVAAGWLGRHFQPDGNLPAAEGEPGIDYLPLGIVALVSAQAGSTQIRTGIRFLESHFESYVRIQATKTSTVDAPGRLAQVILAAVAAKADPRAFGGTAPANDLVARLLATQTHTGWDAGLFGSPAAPTYSSTYTQGLALLALAAAGAPNRAGAGWLLRQQCYAGGWMSYRGTPAVCPAPNAAKHEGPDTNSTALAVEGLLATGVSPRHDPLPFFRRSQYPTGGFGYYGGASAAQTPDPDSTAVVAQALEALGALFATRRDGHDALTGLAAFRIGCRAPAYARGAYQFPGVAGPNLYATIQAIPAAAEVPYPVNAGPASAKLPPLPAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM8</accession>
    <name>A0A7K0JWM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_16645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000953">
        <property type="protein sequence ID" value="MST34343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="350" mass="35816" checksum="5E703D70F7FD9CB3" modified="2021-04-07" version="1" fragment="single">SPLAPGGAARISRDGSIAIVDVTYDAPTPQLPKSDGSTLIDTVKRFAAPGFVVAVNGQLAENAQTEKTSDSTALGAVCALIVLGVAFGAFFSALLPILTAMAAIGIGYSMTAMVSHALTTANFAPILGLLIGLGVGVDYALFIVTRHRNGLRAGRSVEESAVNAVNTAGRAVFFAGITVCIALLGQFALGVSFLYGVAIAASITVALTMAASLTLLPALLGVFGDHVLSRRERRRLAADGPQSEDLTAGFWWRWSRSVERRPAVRAGLGLLIVLVVAAPVLGLRLGLTDAGSDPVGTTTRTAYDLVAKGFGPGFAGPFQLVATLPSPHDAAAFARVVDATAHVPGVAAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR2</accession>
    <name>A0A7K0JWR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000976">
        <property type="protein sequence ID" value="MST34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="20031" checksum="15322D5F8D6CD03F" modified="2021-04-07" version="1">MASPEASAIADLAGVIGRWEFDAAGSSAEFRTRALWVLPVTGKVRFLGGYADAAVAADAGDRLAVEGKISLDAMSVTTGNERRDAHLRTADFFDRDRSETIDFVVSGVRLLAPGRVGVEGTLIVNRMARSLAFEADVERAGERVTLHADIADIDRTDYGMDWARFGASVHNRLIVHASFVRATPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS8</accession>
    <name>A0A7K0JWS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase</fullName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_14930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000809">
        <property type="protein sequence ID" value="MST34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="SSF57774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ADK_lid" evidence="8">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21827" checksum="211C10696BEA735D" modified="2021-04-07" version="1" fragment="single">MNPGARLLILGKQGAGKGTQALRLSRHYVVPHISTGDTFRQAVRSGSEFGQKARQYLDAGDLVPDEIVIGMVRERLTRSDTSHRGFVLDGFPRTVAQADALAKMLNPHGLDLALDLEIDTASVLTRLASRRVCVDCGANYSVIDNPPRVPGLCDVCGGEVVQRDDDTEAAIRRRLELYEQETAPLIAWYEERDLLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV4</accession>
    <name>A0A7K0JWV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001003">
        <property type="protein sequence ID" value="MST34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011195">
        <property type="entry name" value="UCP010256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010256">
        <property type="entry name" value="CoxE_vWa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="52811" checksum="669BAE15ECB16A17" modified="2021-04-07" version="1">MAGFVTELRAAGIPVSLTENLDAVEALRHIPLGDRDAVKYALAATMVKNDAHWKVFETVFDVYFAYRGAEYRLGHNPEDDEGEELVRDLLGAPEGDAGGGMEALSAEQLAELLYRALQEGDRAMLAAVARAAVLRYAGMEPGRPVGGTYYLYRTLRQLDLDAVLARLLGESGGEVPDGDLDDRLRREEYEARIEALRKQVEAEIRRRLVDDRGAEAVARAVRKPLPEDIEFMHASREELVALRKAIAPLTRKLAVRLARKRRHGRRGPLDFRRTVRESLSYGGVPAEPVFKPPRPAKPEIVVVADISGSVAAFARFTLQLVYSISSQFSRVRAFVFIDGIDEVTDYFKGTEDISAAIHRINTEADVIWVDGHSDYGHAFETFWERWGRQIDTRTTVLLLGDARNNYHASQSWVLGELARRARHLYWLNPEPRSYWDTGDSIVGQYALHCDGVYECRNLKQLERFVEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX5</accession>
    <name>A0A7K0JWX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000832">
        <property type="protein sequence ID" value="MST34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="32138" checksum="46E3098E3C68976E" modified="2021-04-07" version="1">MQVPASFTYERAHSVEEAVALLERYGPDARLLAGGHSLLPMMKLRLARPETLIDINDLAELDSIRLVPGRGPDALGADGDELAIGAMTRHATVLDSALLAEHYRIFAEAERVIADPLVRNRGTVGGSLCQADPAEDLSGVFAALKGRAVIRSAGGTRTVPLREFHRGPYETVVGDAEILLEVRVPVRPGAGSAYEKVERRAGDWAVAAAGAFVQLRDGVVVDAGIGLSAVGAEHFTCPEAEDVLRGREPTAASIAEAAAICRDRCEPTADQRGPVDFKRHLTEVLVTRALTRSARRAEGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX31</accession>
    <name>A0A7K0JX31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001042">
        <property type="protein sequence ID" value="MST34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="540" mass="52088" checksum="0664AD401AE2A8B8" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX32</accession>
    <name>A0A7K0JX32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001039">
        <property type="protein sequence ID" value="MST34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="15132" checksum="34C1BC762C8E5926" modified="2021-04-07" version="1">MSDVVDFNQQVIAEFRANGGKVGGPFEGAPMILVHHRGRKSGVERVNPLVSLPLEHGWAIFASKAGAPTNPDWYHNLMASPRTTVEVGGDVVEVAVREAHGEERERIWARQKELNPGFADYEKKAGGRVIPVVVLEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX64</accession>
    <name>A0A7K0JX64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001063">
        <property type="protein sequence ID" value="MST34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="55" mass="6014" checksum="8D13791C243B112D" modified="2021-04-07" version="1">MKCPSCRTRELVVITMKVGAEQVALRTCSSCDLRYWEGLDGQLALESVLALVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR9</accession>
    <name>A0A7K0JXR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000944">
        <property type="protein sequence ID" value="MST34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="551" mass="56397" checksum="CED9F8FECE2B17F1" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS2</accession>
    <name>A0A7K0JXS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001197">
        <property type="protein sequence ID" value="MST34758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="79"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="19344" checksum="8DBE144B3E021E4F" modified="2021-04-07" version="1">GVPALGVRVRTAPDGEILARSNHVFAGYWQQPEETSRAVADGWFHTGDEGYVDEDGYLVIADRKKDVIITGGENVSSVEVEDCIYQHPAVAEVAVIGVPDERWGETVKALVVRRPEQTLDEDAVIAFCRDRMAHYKCPTSVDFVDGLPRTATGKLQKFKLRQPYWEGRSRRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY12</accession>
    <name>A0A7K0JY12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001242">
        <property type="protein sequence ID" value="MST34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14817" checksum="E702646219814D7D" modified="2021-04-07" version="1">MASTGSLTGDTSGAGDLGDRRPAADRAVRRVLRVPERRPASEEAAHRIFSVGIVLSALRCLLTYIFLPVLAPLLGVAGGVGPSIGIPLSVVALTFDVMGIRRYWLADHRWRWPMTVLYLLVMGLVVALLVGNIQTLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF5</accession>
    <name>A0A7K0JYF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001348">
        <property type="protein sequence ID" value="MST34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="7348" checksum="CB972CBB6A40A2E3" modified="2021-04-07" version="1">APAGVIVAAVTAGGGAARAGIAAGDVITAVAGQSVTSLADLSTVLAEHQPGDTVAVTVVAADGSQRTVRVVLEELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH5</accession>
    <name>A0A7K0JYH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001343">
        <property type="protein sequence ID" value="MST34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="233"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="506" mass="55009" checksum="54A96B3636904F71" modified="2021-04-07" version="1" fragment="single">MQSEREGGYAPIGSYGLLGDGHGSALVSSDGSVDWLAVPRIDSAPLLAAIVDDPDGGRLLVAPAVDYEVRRRYVGESMAVETTFATGNGRLRVTDSLNQGFLGRLPWSELARRIEADGDAVPVRWLFQPGTRFATCRPWVHERDGVPFVLAGDLLAALILDGLGEPIVEDGLVRGDAVVRPGSPALLGLVAASEGPVRLPSPSEILRRQDHSIEQWEKWSGLIEYSGPHRAEVVRSALTIKALQSVDSGALAASATTSLPERVGTARNFDYRFGWVRDSAFMIDALTRLHLSQEVDASLTWLLQGVRITAPEVHVFYTLDGQPAGAEQHELGLMDGYKGSDPVMVGNKAAAQAQHGSYGDLFGAIARYVENGGRLDTETGLLVVELSDQLCDEWTRPDAGLWELSDYQRYTSSLINAWSALDRAVALVERGEVPAIHVDRWRLTKDAIHRFVDDRCWSESKSSYTFYAGTDDLDAAVLVAARTGFSAPDDPRLWSTIDAIRAELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI3</accession>
    <name>A0A7K0JYI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dCTP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001357">
        <property type="protein sequence ID" value="MST35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010550">
        <property type="entry name" value="dCTP_deam_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06559">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="22008" checksum="B2C190D9D678F430" modified="2021-04-07" version="1" fragment="single">MILSDRTIREELAAGRIEIDPLDPADVQPSSVDLRLDRFFRVFRNHHQSVIDVKEPQDNLTELVQIEPEGAFVLHPGEFVLGSTAERVRLPDDLVARLEGKSSLGRLGLLIHSTAGFVDAGWDGYLTLELSNVATLPIKLYPGMKIGQISFLRMTTAADRPYGSASIGSKYQGQRGPTASRRVCRPPATASSRRRSRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS8</accession>
    <name>A0A7K0JYS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001159">
        <property type="protein sequence ID" value="MST34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="60" mass="6692" checksum="72D0E8E716679B42" modified="2021-04-07" version="1">QAIGARRPDAREARLLGVSRTATLLTMDRVAYDPEGRPIEQGNHAYLADRYAFRVTLGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV5</accession>
    <name>A0A7K0JYV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001457">
        <property type="protein sequence ID" value="MST35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029530211" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="65" mass="6121" checksum="6D761ECE122167FE" modified="2021-04-07" version="1">RRPMDLGAAAAAVAALSRAAAAHPTVAELEVNPLLVTPGGAYGLDARLVVSPATGGGEGSGGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX0</accession>
    <name>A0A7K0JYX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001451">
        <property type="protein sequence ID" value="MST35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="15215" checksum="C26F721320421241" modified="2021-04-07" version="1" fragment="single">MSSLGPFGSGGPFEDIVRNLARLFSSPGPVNWDVARQFAQWAATGGQPEPNVDPVARVRLEELLRVAELRVGEASGFPTASLLSLRAVTPTEWAARTLEAWKPLLERLASAASESMTPPTGEGAPGGGLGDLSGLFGGAFGQLGGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX2</accession>
    <name>A0A7K0JYX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001415">
        <property type="protein sequence ID" value="MST35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="412" mass="43209" checksum="7EFB18CF5E71D03D" modified="2021-04-07" version="1">LTGLEPTDVEQVKPAGVVGDQGIPEWYRYSAALLVADRTDVIPVPGPYLSYTQRFPVGVTATISSFNHPLMIGSKSVAPALAAGNSVVLKPSELTPLTSLRLAELAAEAGIPPGVLNVVVGRGPVAGAALAEHDAVRKVTFTGGTEAGRSVAAAAARRFAKATIEVGGKTPVLVFDDVDVDDAVRGALFGGFVAAGQTCIAGTRLLVQRTVHDRFVERLAAEAARLRLGDPADERTDVGPVITDHARDRILGWVADAVGAGAQLVTGGRPARPDDAPDGYFVEPTVLAGVDNGDAVARQELFGPVLVVIPFDDEAHALALANDSPFGLGSAVWTRDVARAHRVASGLIHGIVWVNDHHRLDPASPWGGVRSSGTGREGGWESYREFTEIRSVTVRTAPGAVDWFGGREERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG9</accession>
    <name>A0A7K0JZG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001667">
        <property type="protein sequence ID" value="MST35360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="46" mass="5261" checksum="F12DB3D8838D297B" modified="2021-04-07" version="1" fragment="single">MDIHDEIRRYWDADAAVYDDVPRHRPTDAGELSAWSATLARLLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0C5</accession>
    <name>A0A7K0K0C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001554">
        <property type="protein sequence ID" value="MST35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038764">
        <property type="entry name" value="GNAT_N_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41700">
        <property type="entry name" value="PTHR41700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="19145" checksum="621C971D5DACE9BE" modified="2021-04-07" version="1" fragment="single">RAGDAATRAGVRVGLLRRPPDLVEAHRLLAQVWGGEPDVGPDLLRAIGFAGGCVAGAHRDGTLVGVSVALVGWHPDDPAPHLHSHVTGTAPEAQGGGIGFALKQHQRAWALAQGFGEVVWTFDPLLRRNAWFNLARLGAGAPEYLVDFYGDMLDPVNAGQGSDRLLVRWRLDSPAARAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0K4</accession>
    <name>A0A7K0K0K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001612">
        <property type="protein sequence ID" value="MST35314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="17912" checksum="BEF81F00F5A2EB15" modified="2021-04-07" version="1" fragment="single">MPGPALAGRRVVLGVCGGIAAYKAVEVCRRLVDAGAWVSPVLTPGATRFVGALTFSALASEPARTSLWDGPEPIPHTRLGQQADLVVVAPATARLLGAYAAGISSDLLTATLLATRAPVLVCPAMHTEMWEHPAVADNLERLRARGVTVLEPGEGRLAGGDHGRGRLAEPADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0R6</accession>
    <name>A0A7K0K0R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001668">
        <property type="protein sequence ID" value="MST35364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041460">
        <property type="entry name" value="Molybdopterin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18364">
        <property type="entry name" value="Molybdopterin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdopterin" evidence="1">
        <location>
            <begin position="44"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="420" mass="44879" checksum="B858D74F2E618B5D" modified="2021-04-07" version="1" fragment="single">MAHWGAFDVEAEAGRLVAVRPHPDDADPSPLLANVLDAARGPARVTTPAVRRGWWEDGPGPSDRRGSDEWLAVGWDEVLDRVAAELARVRDGHGADAVYAGSYGWASAGRFHHAQSQLRRFTGLFGGATVSVGTYSTGAAEVLLPHVIGDDEAVWRGATAWPVIAAHTDTLVAFGGVPAKNATVSPGGVTEHRVAASLRRAAARGMRIELLSPLRDDVAAELGASWHPLRPATDVAVMLGIAHVLLDEGLADLDFCERYCVGTDRLVDYVTGRVDGVAKSPEWAAAVSQLPAATMRELARRMAGGRTLVTTSWSLQRARFGEQPLWMSIALACLLGQVGLPGGGFGHGYGSLADVGGGRDRVRVPALPGAIRQLRSWVPVARAADMLLDPGGSYDFDGQRRRYPDIRLVYWVGGNPFHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMH6</accession>
    <name>A0A7K0JMH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000011">
        <property type="protein sequence ID" value="MST31160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="11835" checksum="214A6E97417E4E10" modified="2021-04-07" version="1">MAGGGAVVHVLAATDPACAYGSALGWPAKGASRAAGAYVVLVDGLASLYLERGGRSLVALREVDGTWEAAAVDGLASLVASLRASRLALQRYPEQLGPVLRDAGFIPTPKGLVRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMM5</accession>
    <name>A0A7K0JMM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000002">
        <property type="protein sequence ID" value="MST31117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="144"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="458" mass="47309" checksum="07FE9F613D0AA117" modified="2021-04-07" version="1">MDPSRSADHARAGVAARLLAATALLAGTALVALLVVFLVANAGWVALGLAGLAVGVAGAWWALTERMPRLAIGLVGAAVGVAMMVGALVAAAGGLGRVLTGIGIAGGLFVVAVTAARASLDADADADAPAVAGTAVRHPPAHPVLICNPKSGGGKVQRFGLVALAESLGVETLTLQPGVDLEKLALGAVERGADCLGMAGGDGSQALVASVAVRHDLPFVCVSAGTRNHFALDLALDRDDPRHSVYAFRDAVPRRVDYATVNDRLFVNNVSLGVYATIVQQDSYRDAKAETTRTMLPDLLGRTEEPFDLQFTAPDGTEVDGAFLVMVSNNPYVLAASPDASQRRTMDSGHLGVFAVTAATGADAARVVTLALAGHAARSGGAHEFTTEEFEVRSRSGHAYAGIDGEALRLPTPLRFRIHPQGLQLLVPAGNLRAASRRRHRDVHLADLLSIARGQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV8</accession>
    <name>A0A7K0JMV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_00950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000033">
        <property type="protein sequence ID" value="MST31300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="421"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="829" mass="91994" checksum="D52E7E74DB90DA32" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW8</accession>
    <name>A0A7K0JMW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF86 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000035">
        <property type="protein sequence ID" value="MST31306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="11855" checksum="39F2403229B824E6" modified="2021-04-07" version="1">MTRHDDERVCDILDATQQVATIVAGGETAFRADRVRQLAVERLLEIIGESARAMSEAGRGRYPGAPWADIVGLRTLLAHHYHRVDPNQVWVIATVSVPELARLLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI8</accession>
    <name>A0A7K0JNI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000075">
        <property type="protein sequence ID" value="MST31473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="10479" checksum="DB3BFB89C851A96A" modified="2021-04-07" version="1">MIAIGSVEHLGLATLLVGVAVIGFALGIVETLEPTVMSVLRSGARTGAGMGALSAARGVGTFAGNLAMGLLYGVGASLAYGYAAVVAALAGVLVLSAIPASRRQAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR2</accession>
    <name>A0A7K0JNR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ORF">GHK86_00540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13570" checksum="489840C3D9AABC5D" modified="2021-04-07" version="1">MIQQESRLRVADNSGAKEVLCIKVLGGSKRRYASIGDVFVATVKDAIPGANVKKGDVVKCVVVRTKKEKRRADGSYIRFDENAAVLINDQQQPRGTRIFGPVGRELRDKRFMRIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS0</accession>
    <name>A0A7K0JNS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="174"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="38905" checksum="800B8DCE16F80C17" modified="2021-04-07" version="1">MGQACRHRRRTAGGPLQRRAGGAVPAAAGEPPPAGRCRPAQASDGFLREGDPVKLDGFIEAEEAAGHSVKHACELFEVSRSAYYARKTHTPSPRAASDAELLEAIRKVHADSDGTYGAPRVHHELLARQVACGRRRVRRLMRIGGLEGRCKRRWRKTTIQDPAAEAEALDLIRRAFGPGRVLDARYVGDITYIPTWEGWAYLATVIDLASRRVVGWAIADHMRTELISEALLNAFHARRPAAGVIFHSDRGCQYTSRDYRQLAVDHGVTLSLGRKGTCWDNAVAESFFATIKRELIDRRSWPTVAGLRRAVFDWIEGWYNTRRLHSTLGYLSPADYEARIHHSTRPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC3</accession>
    <name>A0A7K0JPC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000139">
        <property type="protein sequence ID" value="MST31798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="16078" checksum="3B505BF1A1C02803" modified="2021-04-07" version="1">MGSEHQGRKRAGRARLRQEVVLSSRIEKEFVGTPAAVRQARAFVEAALAAWDLDDVAEVAVLLTSELTTNAVRHARTTFTVAVACRPPELLVEVGDGSDALPVQRPKSVRSEGGRGLQLVAALARSWGTRRRRGGGKVVWFQLDLPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD6</accession>
    <name>A0A7K0JPD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000064">
        <property type="protein sequence ID" value="MST31419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:alkyl sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="102"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="628" mass="67744" checksum="F27DD8F8467AE97D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG9</accession>
    <name>A0A7K0JPG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000135">
        <property type="protein sequence ID" value="MST31787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="425" mass="46086" checksum="5DDB4D2F19484AE2" modified="2021-04-07" version="1">MASNVQPPRGMRDFLPDEKARREAVLAAIRDSFGSYGYREIETPVVEELNRLESGEGGDNEKLIFRIQKRGLDPDAPLPPGSAADLGLRFDLTLPLARFYATHRAELPEVFRAIQIAPVWRAERPQRGRYRQFHQCDIDVVGEPGPVAEVELIVATLDALEALGVQGGSVRLNDREVLAGLLDACGFAPEAQPGVLVTVDKLDREGLEGIAKELAAHDLPAGPSERLLDVLGELTAAEGDFDATLATLPGRAPERAERLLEIRDGVLEAKPDARLVADATLVRGQGYYTGTIFELSHPGYEGSIGGGGRYDGMVGRFLGVDVPACGFSIGFERVVDLVDPARFRAARRRVALVYTDEVPPGRLVAWQRRLIGVGADVRLVPRRRNLGRQLEALGAEGFGEWAELDGTTRPPATSGAAGLDLRDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH3</accession>
    <name>A0A7K0JPH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000157">
        <property type="protein sequence ID" value="MST31866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="29031" checksum="D63FAACBF0446816" modified="2021-04-07" version="1">MTTSDLPKDAGARLQELEHGMFTSDLSVNEFLLVKRAGFHPLGLVMGSSIYHIGLQKGNWGSSQEMTKLSEAMYNARELAMKRMEEEAEQLGADGVVGVRLDVKFYEWGNDSAEFIAVGTAVKAEDGRSYRNNQGKPFTSDLSGQDFWTLTQTGYFPLALVMGTCVYHIAHRGLGQAIGQLGRNGELENFTQAMYDARELAMKRMQDEATNLAAAGVVGMRLEEKNHMWGEHTIEFLSLGTAVARVGDAPVTIPQPTTIISFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR5</accession>
    <name>A0A7K0JPR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000165">
        <property type="protein sequence ID" value="MST31887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="238"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="419" mass="47132" checksum="37B6D60CFC2E8372" modified="2021-04-07" version="1">MPAPRKYDQETRDRAVRLYQERRRDHGNESAIESRRRIGELLDINPGTLRGWIERVEVDAGVRPGVTSEDNAELVKLRKENAELRRANDILKTASGFFRGGGARPQTFLIVDYIDAYKDRFGVEPICRVLSEHGIQIAPSTYYAHRSAQRVSQADWDDAHLANQLADLWRANRSLYGVEKLHAAARRAGIDIGRDQVARLMGIAGICGVTRGKHKTVTTRRDKTAGRHPDHCNRQWDTPTRPDQWWVADFTYVWTLMGFVYVSFVTDVFSRRILGWRVSTSKTTPLVLSALEQALFTRRRTDVRFTSTGLVFHSDAGSQYTSLAFTEALIEAGITGSIGSVGDALDNALMESTIGLYKTEVIGQNARSWTGLRDVEAATAEWVHWYNTTRLHSSIGLLPPLEYEADYLMSTAFPTGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS3</accession>
    <name>A0A7K0JPS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="25882" checksum="14DE17DE65DF807A" modified="2021-04-07" version="1">MATAVPVYPDLSGKVAVVTGGSRGIGAATVRALARNGAAVAAVARDREALAGVVATVGEGGGRAAGVVADCTDEHQLARAVGQIHDQLGVVDILAAFAGGDGMPVPTGSETAEHWRHVVDNELTSCFLTVSAFLPDLTASPTAAVITMSSAAGRQAAGSSAAYAAAKAGVVALSRHLASELAPYKIRVNCIAPSAIENDKMRVWVSAEQRAALATEFPLGRLGQPDDVANAAAFLASQASSWITGITLDVAGGKIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV2</accession>
    <name>A0A7K0JPV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000103">
        <property type="protein sequence ID" value="MST31599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="18090" checksum="107CA18B2A1C9302" modified="2021-04-07" version="1">MRRLERLSAGHDLSRFHSGNEELDSWLRAHAWAAQQMDQVRTFVLIEDDRVIGHFGLTMGSVRRDEPPAGLVRGLPGYPVGMVLLARLAVDADHQGNGVGAQALAEALRRAVTAGEAAAARLVVVDTIDTAAVSFYAHHGFVAVAEHPQRLYCRMQDIRASLDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ24</accession>
    <name>A0A7K0JQ24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="15643" checksum="2624A3DD505D3658" modified="2021-04-07" version="1">MPWPDPGLERVGHRPGSPYVEACWVSVIGPSAAWAWQRLARQAVSHPGSSVEVAELSASLGLGAPHGRNATIYRTLARLASFGAATPGPAATLAVRTALPDLAARHLSRAPQSVRAAHHALTGRPLPPPTRSPLTPDPVIDPHPVPVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ4</accession>
    <name>A0A7K0JQJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000155">
        <property type="protein sequence ID" value="MST31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="344" mass="37266" checksum="E5AF22A005FC2737" modified="2021-04-07" version="1" fragment="single">MPDPEQRPGGGEVAADDDPRLASPHGRQRRLQLPLPDDTHRAVVAQRAVTPRRLLSSGGGRAVLVVHRSERADRLVESLGDLLVVPPDDPFEPEVVAVPTRGVERWLTQRLSHRLGAADDGGVCANLRFPFPGALVGAATAAACGLDPDDDPWRPERAVWVLLDVLDERVEDPGLATLVAHLRATTPGDGGDAGHLRRFSALRHAADLFDHYAVHRPGLVRAWHDGEGEGWQPHLWRLLRARLGVPSPAERFDVAARRLAEDPQLVDLPGRLALFGLTRLPPSHLEILQALAAGRAVHLLLLHPSAALWDRVAPLAVGVAPGLARAEDPTARVPAHPLLRSWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN6</accession>
    <name>A0A7K0JQN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4190 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000252">
        <property type="protein sequence ID" value="MST32241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="12711" checksum="92ADAAAD19943199" modified="2021-04-07" version="1">MTWGDNMSSSGGQGGFPPGYSPGPGPTPQPPWGGPPEQQATNGFAIASLACSVAALLPFVGIVGAILGIVFGFVARSRIRMSGERGAGLAMAGIVVGTVMLVVAVVLLAVILGAVTTVVHNNSPGGLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR08</accession>
    <name>A0A7K0JR08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000279">
        <property type="protein sequence ID" value="MST32370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="9937" checksum="A30A172764E24C08" modified="2021-04-07" version="1">PPATLARRDLEAALDGFDPHGVVVHPRLVEGTVAAALLREARSAELLVVGSSLPRRGVPPLDSVGLSCARHASCPVVVVPMSPSAPAGGRLGRHAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR25</accession>
    <name>A0A7K0JR25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="166"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="399" mass="44202" checksum="B31EB0947041626E" modified="2021-04-07" version="1">MAHIQKRQRGGEVRYYVRWRVDGREKVRSFARARDAETFRRQVEHDQVLGLHVDPSRGAVTFGAYAEEWLRGRRRADGRPLAPRTAELYRYQLDRFLLPALATRPLRSIRTEHVRDMHAGVCEQASPLQAAKAYRLLRVILNTAVEDERITHNPCKLRGAGVERSPERPFVDADLVLALAVAIDERYSCLVLLAGFGGLRLGELLALRRHHIDLERHTVTVAVQTIELKNGERLTTAPKTDAGRRVVHLPAQVAAALAVHLDRYVGPDGDALVFTGPRSSELRRATFYTEWDRARKAVGLDHVHLHDLRHAAGTLAAQTGATTRELMARLGHATPAASHRYQHAATRRDAHIAAALDDMVDRASAASLPLMRGGCGAGALEAPARPPGTTAENAPDQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR35</accession>
    <name>A0A7K0JR35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000281">
        <property type="protein sequence ID" value="MST32382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="24762" checksum="72D9EC4DD49EC4C8" modified="2021-04-07" version="1" fragment="single">MSADASRADRLDRASPLPLWAQLLDDLRSRLGAGELDERFPAELELAADYGVSRNTAREALRRLRNEGTLVSARGRRPRLNPGIRQPLGAFYSLYESVAAAGLTQRSVVRSQQVRKNPVVARRLGLSPSAPLVAIDRVRIADDEPLALDEVYLPEAVGRPLLDADLGSGSLYEHLARLAGVRLSDAEETLGATTATVAQAEELQLPAGVGLLSIERIGWADGRPVEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD6</accession>
    <name>A0A7K0JRD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000311">
        <property type="protein sequence ID" value="MST32492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029761909" evidence="2">
        <location>
            <begin position="18"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DAO" evidence="3">
        <location>
            <begin position="60"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="350" mass="36209" checksum="64A40AE7F1D96934" modified="2021-04-07" version="1" fragment="single">MRGTPSWCPTARRRACGATSPAGATGRSPVSTSGGGSRSGSRPPPAPEVASDPSGGRVTRVVVVGAGIVGLSCAWSLQEHGVEVEVVDRRHPGAGASWGNAGFLSPALTVPLPEPSILRYGLRAVLDRHSPVAVPVPPTGPVLGFLARMVRYCTAAHWEQAMAAYRPLNEQIFAAFDRQTSGGVDALTTPGDLVAAFGHPAEAAGVLAELQGVVAAGLEVVVEILTGEQARAIEPHLSPAVSTAVLVRGQRYITPHAYVAALAEQVRIRGGKITEGLAVSGVERRGDRVVVADTDHQLEADAVVLAAGSWLSPLARPHGVTVPVQAGRGYSFTVPCTTPLRGPVYLPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE4</accession>
    <name>A0A7K0JRE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07719">
        <property type="entry name" value="arylsulfatase_AtsA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044094">
        <property type="entry name" value="AtsA-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="135"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="422" mass="44933" checksum="5529A62D309B7050" modified="2021-04-07" version="1">MATALSLAMLTDAVRSHRMFRSPARLRSERGVVMGNGSSPGLPELAYMGGTTALTTTPIVGTPAQPYADIFVPGQEPIRDAEMRVTVLGSGNPPPTRAQASGSVLVEVGNPDRDMFIFDVGSGCLANFMCLGLPINSLDKVFLSHLHADHTADLITLFGSFRKAGRKGPLYVWGGNGSEPKYGSKVAIEAIAAACAWDTESTRGYTPNEAADMFGTEFDASITSVVYEANGVTITAFPVIHNLHGAVGYRVDFAGLSMVFSGDTRPCWPLVRAAQGTDLLIHECFPPAAVLAQLTGDRIERFETITATHTVPKAAGKVFSLAKPRMAGLWHTLLVPPVVAPILEEVGAVFDGQVVQTQDLTVFNITKEAVVARQAEAVPQAIAVPGKPKVEPTYDHRPTPPDWWSEALIAEELSASQPAGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH0</accession>
    <name>A0A7K0JRH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000327">
        <property type="protein sequence ID" value="MST32548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="14761" checksum="0C4A8886D8D21210" modified="2021-04-07" version="1" fragment="single">MRRVHRSRAAVRYGRRRGREMDGSRTMIGRADEDGLGRLVGASTLSRGRSYAAAGAVLRREWDPSGLSLVGEVQGSASRPYRVAVNLRRVGGGAMEVLDLRCSCPVGVNCKHAVALLLAPAPRRPNLTLLRGGAAGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH3</accession>
    <name>A0A7K0JRH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000234">
        <property type="protein sequence ID" value="MST32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="18300" checksum="9F3AF12692BB8C4B" modified="2021-04-07" version="1">MADRLTEKLEEVARTARQQSLCPHPHDHLAFVRTITASGATNIWWRCSDCHANVLGSGYWVPAEYLEETGVDIDTLEIVSDKRSTTPPCVVCGARGTENHHWAPRHLFGTEADLWPTAWLCRSCHQRWHRVVDHQGKLAVVPLPLEGDGDHPEREPTPRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK2</accession>
    <name>A0A7K0JRK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000334">
        <property type="protein sequence ID" value="MST32576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="201"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="403" mass="42550" checksum="A1D0743350FED6F5" modified="2021-04-07" version="1">MTETAGASVPTEVDRSLLEEAGRLLDDTVALRRRIHAHPEVGNELPTTQQTILEALDGLGLQVATGEAVSSVVAVLDGDEPGPTTLLRGDMDALPMPEDTGLDFASEIDGRMHACGHDTHVAMLVGAARLLRQRRAQLRGRVVFMFQPGEEGHGGAKIMLDEGLLDRHGPIDRAFAIHAIANLPSGLVTTRGGTLMASADEFRVTVTGRGGHASMPHDAVDPVPVACEIVTALQAMMTRRIPAFDPAVLTVTRIQTGTAFNVIPEVAYCDGTVRAVSDASRDRVVEGLREVASHIAAAHRCTAEVDLVDNGYPVTVNDAAAATRTLGVATALLGERHVLAMPTPVMGAEDWSYVLQRVPGSMAFLGVARADDPDPAPNHSNRMLVDEPAMAHGVALHAAMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK3</accession>
    <name>A0A7K0JRK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000330">
        <property type="protein sequence ID" value="MST32560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="24973" checksum="D50354D96D708073" modified="2021-04-07" version="1">MQVLVVEDDPKIALFLERGLGAEGHVVTVAGSAEDSRRWLAALGSQLDLVLLDLGLPGEDGTELLRSMRAGGFAAPIIIVTARDAVRDKVTGLDAGANDYITKPFAFDELLARIRAVRRSAGQPAQTELVVGDLRLDLLTKVAQRGGRQIELAPREWVMLELFMRHPRQVLSRTQILSNVWHYSFEPGSNVVDVYVGYLRRKINLPGLAPLIQTVRGAGYRLQPPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP4</accession>
    <name>A0A7K0JRP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000336">
        <property type="protein sequence ID" value="MST32587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="495" mass="53384" checksum="1297229154FC79FE" modified="2021-04-07" version="1">MAKPRSRWQSRSTEPETHTQRDPRPRPPFRGRRAKRRRSGAPRHPVARRWTEAAADWPGSALLLLVVGLVGSLAFSGVLDGVVVDRGPALWAVVAVSGAGALLGLATRPPDWWRRRAPWVAAATTVVVVLAWAWLRSSGLTGNTPYPASFLVLAWLALFALGSGLTGLHTGPQALRTTRILAGPAAVLGVFLVINAFYGYWPTVGTLLGHPLPGQVSGHRFAAALRQRKPTTATGELGPVSIPGTAVGFQAARAYLWIPPDWSRVRHADLPVIVTLTGIPGTALDWARAGGALAASSTWAASHGGLAPPVLMLNQNGLADHDTECLDSREGAAYSYLTQVVPHYITHVLGIRHVSDRWGLVGFSEGGTCSLMLSLTDHRLFGRFVDIAGDAAPDFGPGGRLTLKVLYHGNRALERAHTPRLLLAHHRYPSLQGWFAAGLQDRGHRVLEPKLAADAARAGIRVSTYWAPGHHTWTFARIAFEHLYPSFVRSLLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR3</accession>
    <name>A0A7K0JRR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="363" mass="39485" checksum="AB1CF2DF6A52D9ED" modified="2021-04-07" version="1">MDAQPWLAAAAVLCLIAAFLWARASSRMARAARRIEAETAGANTGEDAAELARVAYQKDLHNAVLYIVIGIGLGMASLSRSPWFEVPLLLVGVPVAVTLRFAPRVFDEARHSENRSVLERRAEEVLVQQDLAPRRWSERLAPEELPPTEGFELGRVYEPGSGLMAGDFYDVYPTGPNRLACVIGDVAGHGVEPSITAFQVKYLLRNFLLQYRDPAQALEELNKVLSVTGRPEDLVSCCVVVFDTEAATLRHASAGHPAAWLWHDGGMRALRSTGPLLSLDPQGTYVSRELPLQPGDLLLLYTDGLAEARSGGQLFGEDRIAQIVRRDPGQDADTVAKSLLAAARDFASGPLIDDVAILVVRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR5</accession>
    <name>A0A7K0JRR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="19523" checksum="A6F1181B7D8A4934" modified="2021-04-07" version="1" fragment="single">MRASDGGGGRDPAVAAARDPLSLSDLVARTGIPASTVHHYLRSGLIPPPNREAPNRFSYDERHVAALRAVRRLRETRGLSLEEIAAVLPELGAHPELADGPDRPEVDGGAADRLVAVAIEAFREHAFEEVTVADLALRAGVAKGSVYHHFASKEELFAAAVGRVLAETADAFADVVGRLGGPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT7</accession>
    <name>A0A7K0JRT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8886" checksum="741F1BC50601173D" modified="2021-04-07" version="1">MFDQLRQIVARATAIDTARLDPQADLYDRGLTSHGTVQLMLQLEDAFGVEFPDELLKKETFTSLQSIAGALASMGVEASSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU3</accession>
    <name>A0A7K0JRU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="44"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="12994" checksum="F31F55A733D7309A" modified="2021-04-07" version="1">MLTLELAGVSVRFTVAADGDVVWVGAEGSAWAVREAAPESARASGAAGSHGPVRSPMPGTVQAVHVAPGDTVVAGQPVVTVEAMKMEYSVAAAVAGVVATVRVRPGQAVALEEVLAEVHEADPATGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV0</accession>
    <name>A0A7K0JRV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000358">
        <property type="protein sequence ID" value="MST32676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="40"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="464"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="555" mass="59061" checksum="73E4C28562D65D6E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW8</accession>
    <name>A0A7K0JRW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000359">
        <property type="protein sequence ID" value="MST32681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="740" mass="82249" checksum="FA8E8B2AB527C437" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS09</accession>
    <name>A0A7K0JS09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000365">
        <property type="protein sequence ID" value="MST32703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="380" mass="40057" checksum="8E26BC39BB073720" modified="2021-04-07" version="1">MARASTDSHYEVLGVSPSADAAEIEAAYRRLLKVTHPDAGGSAALFRRVQDAYQTLINPARRASYDRDLRGPRREPQGDDGAAGAPGWVRTDTPPPPPPPGSSGPPPGPGSAPPPPPPPGPGRPPPGPDPGWSSPGNRRGPHMASPPSPPPPQPGPSAHAPVWLAARPWILPLGAGLLLSGLPALRGLAVLLVVVGFLAALGSRRVERAVEMGRAGIGQIDQMDGTTFEHYLEELLRTHGYKVKHLGRVGDFGADLLVEREGRRSVVQAKRYASNVGIDAVREAATARQHYGADGAIVITNSAFTRAATELARTNHVELWGRPRLLQLASSVSAVPVPTGPALLGRQLLAGAWVLAKVLGFFALVSLSAGGAPRRRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS66</accession>
    <name>A0A7K0JS66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000382">
        <property type="protein sequence ID" value="MST32763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="4">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="26778" checksum="0C8FF846B02D5BFD" modified="2021-04-07" version="1">MDIAVCVKHVATLGDEVEFDDEGTDVDPDYLEWTINEWDTYAVEEALRLREAAGSGEVVLFAVGDEEADESLRRGLAMGADRAVRIDPGGDAGVLDPLIVARALAGAVGELGPDLVLAGVQSSDAVQAATGTMLGQLLGLPTVAVVKHIELDAGAGRARVHRELEGGLIHVLEVATPAVLTVQTGINEPRYANLRAIKQAKEKEIAVRDLETSEGGCATVLRMFAPPAGETAELLGEDPAEVAARIVELVTARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS86</accession>
    <name>A0A7K0JS86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_08790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000398">
        <property type="protein sequence ID" value="MST32816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="38462" checksum="B40ED4CCE6B45C6F" modified="2021-04-07" version="1" fragment="single">MTLTDHDLSELLAAVQAGDMTDTVRLSVAWVLQQLIEAELTATIGAAPGQRSESRTRQRNGHRPKLLTTAAGDIEVGIPKLRTGSFFPSILERRRRIDRALFAVVMEAYVHGVSTRSVEELVKALGAASGISKSEVSRICGELDSDLEAFRTRPLEGSFPYVFADATYVKARVRGRVVSRAVVVATGVRADGGREVLGLAVGDSEDGVFWAEFFRSLRNRGLRGVKLVISDHHLGLKKAISEVFVGAAWQRCRVHFMRNVLARVPKASTEMVAAAIRTIFAQPDATHVGAQLEEIARMLEAQFPDVSRLLVEARDDLLAFAAFPAAHWKKIWSTNPLERLNGEIKRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI8</accession>
    <name>A0A7K0JSI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000427">
        <property type="protein sequence ID" value="MST32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="7"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="497" mass="52820" checksum="FADC1B023FF3D13B" modified="2021-04-07" version="1" fragment="single">MRSFPSSAIRNVALVGHGGAGKTSLTEALLFGAGALSRMGRVEDGTTVSDFDPEAVKHRISVSLAVAPFEWEGHKINLIDTPGYADFIGEVHAALAVADLAVFVVSAVEGVEVQTRVAWRLAAEAGIPRLVFVNKLDRERASFDRTLEQLRSAFGAGIAPLELPIGEEGAFRGVADLLTETAITYEDGKAIAGPLEEGMVPAEHEVHDALVEGIVVADDGLMERYLEGEVPSVAELEKTMARGVAEATVFPVVCGSATKRIAVDRLATFLCEIGPSPADRPPVQVSAGGGTHPVPADAGGAPLAYVFKTLVDPYVGKVSLFKVLSGTVRPDETLVNTRARSEERLHGIFGLLGKEHLELTEVVAGDIGAVAKLNGTLTNDTLAARTMPVAVPGFTVPEPVLSTAIRPRSKGDDDKLMTALHRLQDEDVTLAVRRDDETHQTVLSGMGETHLAIVLERLARKFGVEVDQEPVRVPYRETITATAEAEGKYKKQTGGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN7</accession>
    <name>A0A7K0JSN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.61" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="12"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="21642" checksum="37B4F0AF290E0D85" modified="2021-04-07" version="1">MTGRSYERDGAEIYRRSFETIREEADLTQVPGDLEKLAVRVVHSCGMVDVVADLRFSAGAGRAGRAALAAGAPILADAHMVADGVTRSRLPAGNDVICTLGDPQVAELASARATTRSAAAVDLWSARLDGAVVAVGNAPTALWRLLELLDSGAPRPALILGFPVGFVGAAESKQALVEAAHGVPYVTVLGRRGGSAMAAAAVNALATERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR1</accession>
    <name>A0A7K0JSR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000445">
        <property type="protein sequence ID" value="MST32982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="106"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="398"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="616" mass="64859" checksum="FAD13AD911D016CE" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD4</accession>
    <name>A0A7K0JTD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000511">
        <property type="protein sequence ID" value="MST33190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="133"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="23496" checksum="2C47DDF1F32F98F3" modified="2021-04-07" version="1">MHVIVVGCGRVGSELATSLVTAGHDVVIVDKHPASFRRLAEGWGGRTVVGLGFDRDTLAVAGVREAGALAAVTSGDNSNVLTARIAREYYQVPNVVARIYDPRRAVIYQRLGIPTVATVTWTVDQVVRRLLPDQLVTEWADATGQVVLVERSLSARWVGRSLDPLEVPDVCRLVSVTRGGAPRLARPGLIGQEGDILHLAVRKDHLDQLQRDLGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK5</accession>
    <name>A0A7K0JTK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="9577" checksum="287C02CA149C7643" modified="2021-04-07" version="1">MLVPAESDSLYTSALHIERGWWLKRHRSRWVRYYIDDAAADGWEREPVDLSGDVLEVMEALHDQWHGSWDSLLEAANLLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP6</accession>
    <name>A0A7K0JTP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000559">
        <property type="protein sequence ID" value="MST33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029911882" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="15113" checksum="9BF58050F6885330" modified="2021-04-07" version="1" fragment="single">MGLVAAACGSSGATTTSSAGASTSGSHTAKATVAVKLAAAHGVGKVLVAADGLTVYSFSKDGKDHPTCAGSCAKVWPPLTVSGTPGAGSGVKASMLGTVKDADGKTQVTYNGRPLYTYVADTKPGQAAGQGINAFGGKWWAMTAAGAAAGSTASTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX8</accession>
    <name>A0A7K0JTX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000580">
        <property type="protein sequence ID" value="MST33397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="40"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="15927" checksum="86C3CCE62D64D6EC" modified="2021-04-07" version="1">MDDRRRRADRDLSVPGGDAGQGLRGRAARDDDRRGATVSLQHVVLFHFPADLPAGEEADLRARVAAWPAEIGGMTAIRFGRARWTDRTRGYQYLLYMEFPDEEALRAYQQHPLHVEFAAWVAGLGNTALAFDYPLDDTTVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX9</accession>
    <name>A0A7K0JTX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate/aminodeoxychorismate synthase component II</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000469">
        <property type="protein sequence ID" value="MST33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="21993" checksum="3A57CE8F8DAB0F9A" modified="2021-04-07" version="1">MARVLVVDNYDSFVYNLVQYLGQLGADPVVRRHDAIDLDGVAALRPDGILISPGPGRPEDAGVSTAVIRAWAGRVPLLGVCLGHQAIGAVFGGRVVRAPVMHGKTSTISHDGAGIFAGLPEPFVATRYHSLVVEEAGLPAELAVTARSEDGTVMGLRLRREGAPVEGVQFHPESILTEGGHRLLANWLAACGQADALARAGEAALTTRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU22</accession>
    <name>A0A7K0JU22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">GHK86_12040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000599">
        <property type="protein sequence ID" value="MST33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15692" checksum="1D2E919CEBDD6CE1" modified="2021-04-07" version="1">MRSVDVNVLVYAHRSDAPDHEAFRAWLDGARGGEEPLGVTDLVLSGFVRVVTHPRMFADPTPVELAWSFAAGVRSSPAVVQLAPGERHWDLFQQLCTATGARGNQVPDAFLAALAIEVNATWMTADRGFARYPGLRWAHPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU49</accession>
    <name>A0A7K0JU49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">lexA</name>
        <name evidence="16" type="ORF">GHK86_12185</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="WJHE01000608">
        <property type="protein sequence ID" value="MST33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="89"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="96"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="23140" checksum="E81D370505326300" modified="2021-04-07" version="1">MSDTELTGKRREILEFIAAQLRERGYPPSVREIGEAVGLTSSSTVHTHLQTLQRQGYLRRDPTKPRAIEVRYDANSGAAIERRPARHVPLVGDVAAGTDVLAQERVEELLPLPEDFTGDGQLFMLRVRGDSMIDAGILDGDFVVVRQQDTADKGDTVVAGIPGDEATVKTFGRRNGKVVLIPHNPTMEPIVLDPEDVHLYGKVVTVLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU52</accession>
    <name>A0A7K0JU52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1565 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_12025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000597">
        <property type="protein sequence ID" value="MST33443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029645763" evidence="2">
        <location>
            <begin position="37"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="129"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="392" mass="39220" checksum="DEFBFA7379182572" modified="2021-04-07" version="1">MKPTATRRRIISALAATTLMFGGAGVATVAATTATAAAAPTTVYVATTGHDSSTCGTSSAPCATIGQGVTNASAGDTVSVAAGTYNEQVVVPKTLMLVGHSAVVDPKGATTGSGTSMDAAAIEVLPAASGTTIQGFTVQGATGEGILVISARHVTIRGNHVSNNDIGTPSTTTYPECQPEGNVPGDCGEGIHLMSADLSTVIGNSITQNSGGVLVTDELGPAFGNLIAHNYVAANLFDCGITLPSHSTTAVGLGGRPVPSRGGVYGNRVLHNRIIGNGILGNGAGVLIAAAAPGGASYNNLVAGNVIYGNGAPGVTLHAHAPHQYISGNVIQGNLIGTNNVSGDPVAKVFATTGVLVYSAVPRVHVVVVIRHNVIIGNVHRIWTTPNVRVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU76</accession>
    <name>A0A7K0JU76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000616">
        <property type="protein sequence ID" value="MST33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="9105" checksum="5734EF82176A9131" modified="2021-04-07" version="1">MSFEDLPCRDFVELATDYLEGALGPEQRLVVELHLGFCRPCVDYLDDMRAAIAAAGALRRTDVPEPVVEPLLEAFRALRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD0</accession>
    <name>A0A7K0JUD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000633">
        <property type="protein sequence ID" value="MST33538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13890" checksum="C0701C6974BE7F14" modified="2021-04-07" version="1">MAPAVKPLALVVTCGCGERGRVLPGASWTCPSCGRSYGTGDVPQEEYAAVVRDVNRTKLRAIFGMALIAAVFVPLGIILGGEVWMTGAVVLAAFYFWYGPRVKRDVRRILRDLPRWEIREQDGPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE2</accession>
    <name>A0A7K0JUE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000513">
        <property type="protein sequence ID" value="MST33194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029636197" description="Cell shape-determining protein MreC" evidence="5">
        <location>
            <begin position="30"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="233" mass="23855" checksum="EEF592B7972796FA" modified="2021-04-07" version="1" fragment="single">MAVVRRPTRLRFLVAFLVLVSLTLITLDASGHGKSALQGARNAFNTVLTPVQSGIHAALRPVGNFLTGAADYGQLQAENRRLRSELAQVRASQVAAGFAQQQADQVLALHHLPFAAGIRDVTAQVINVSGSNFSSTITVNRGRDSGVVYGQPVVAAGGLAGTVSAVTAHTATIKLLTDPSFVVGVHLPGGNTGQAAGRGGSSSLQVTVLPASAPAPKIHKGQVLVTSGLSMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE5</accession>
    <name>A0A7K0JUE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000645">
        <property type="protein sequence ID" value="MST33576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="470" mass="47827" checksum="269DB588B99CF89F" modified="2021-04-07" version="1" fragment="single">PRPSAALGGPARLHVVVLLAAVLGLQSADTGAIGSLAAPIEAAFHVGNVALGLLATASTLIGAITCLPFGVLVDRRNRTLLLQAVCVVWGASTVVSGASTSFGMLLLVRVFQGGVTAVAGPAMASLAGDLFPSDERGRLWGYVLTGELAGAGIGILFTGILSELVGWRVALSALGVPAFVLAWALRRWLPEPARGGAARLQPGATSIPVATGPARTSGGVRRVVLAPPSDVERQAERLGARPYPGTVVQGPDDLDLRAAVRHVLRIRSNVALIVASGIGYFFVQGLETFVELFFRERYGVGQSVASVLFVVIASGAVIGVILGGHAADQLIRGGRASGRMIVGALSFAGVTGAFAPAVFLPALAYAGPALAVAAVFLGAVNPPVDTARLDVVPSFLWGRAEAVRTTLRQSLQGFAPLLFGLVSTAFGAHTGGFGAGVDTARTGISAPTGEGLQAAFALFSIPMLLAGMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP7</accession>
    <name>A0A7K0JUP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000687">
        <property type="protein sequence ID" value="MST33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="227"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="417" mass="45865" checksum="92F4F5B4F61A0055" modified="2021-04-07" version="1">MKIAVWHALPSGGGKRALYGHVKGLLARGHEVEVWEPCGEERRYLPLSDLAPVHQLQLPAISGGRLARAVRQAVFDCDVVHEMYDIHCRRVGEDISDGRFDVLFANTAATVHAPPLSQHAMVPSLLYLQEPQRRLYEALPTPPLSAELVGLRGQPWRRGVALAKWMYETRRKGVRVRNEVADAAGYDCLAVNSFYSRESVLRAYGLNSRVCYLGVDLELFTPRVSPTRDYLVTVGAGTPLKNIKFIVAALGTLPEKERLPLEWIANSAHPAELDGVKELAEKYEVDLRIHINLTDRDLVALLGGALAFVYAPRLEPFGLAPLEAAACAVPTVAVAEAGVREAVVDGRTGVLTGGEVSEFAAGLLEVVRDRAFASKMGASARYFVEERWTLEHASRRLEKLLVDVVLQARVASHKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ2</accession>
    <name>A0A7K0JUQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000685">
        <property type="protein sequence ID" value="MST33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="231" mass="26161" checksum="2C12905F87931BBA" modified="2021-04-07" version="1">MTTTMTAEPSLLQTTIGKKVAMASSGVILMLWLWAHMLGNLKLWLGNGIYNNYAHWLRAGFDPPFPYAWFLDIIRAVTLIALAVHLYFAVVLSIRSKRARRAGYQRTERVQANVASMTMRWGGLTILLFVIFHLAMFTWGWITPGFRYYFGHPAQMVVGAFQLWWMVVIYAAALIALALHIYHASWSMFQTFGVNNRRWNTAVRRFAAVNAAALFIGFMSLPLGVISGAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR5</accession>
    <name>A0A7K0JUR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000684">
        <property type="protein sequence ID" value="MST33668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029800273" evidence="2">
        <location>
            <begin position="34"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="26563" checksum="71E3378E6CF000CC" modified="2021-04-07" version="1" fragment="single">MPSRTPPARRRRGVPSLLALAAAGALLAGCAGSAPVDAGNSAAGNSPVTASGGGASAGGTSGSTSGGGTGGGGATHHGNVDVLSAGSLETILTKTVGPAFHRATGYTLVDTSGGSSSLAAEIKGKTQVADVFVSASPAVDATLEGAANGGWVSWYATFAKSPLVLEYYPRSRFARALRTRPWYDVITDKGFRLGRTNPAQDPGGVLDAEALDRTASSRHLPALAAIAKDPSTEYAETALPGEVQSGQLDAAFAYLADANSTGLPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS8</accession>
    <name>A0A7K0JUS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000556">
        <property type="protein sequence ID" value="MST33314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029848935" evidence="2">
        <location>
            <begin position="37"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="11605" checksum="3138255EA6FE907A" modified="2021-04-07" version="1" fragment="single">MASTTRELGLRQVRNLTGWLAAGSLAAAVFFGVAAASSHPAKTVKSSLGNSSLGNGNGSGLGTTGGDGEGGDDGSGSTGATGASGGTGAGVSLPSSRWDTDWFWCSRAFGVQRPGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT9</accession>
    <name>A0A7K0JUT9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <ecNumber evidence="3">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">treZ</name>
        <name evidence="12" type="ORF">GHK86_13410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000696">
        <property type="protein sequence ID" value="MST33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="99"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="243"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="375"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="576" mass="63169" checksum="F8688E131E65B859" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW1</accession>
    <name>A0A7K0JUW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000705">
        <property type="protein sequence ID" value="MST33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="224"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="32927" checksum="8E4F434BBB6D7E0F" modified="2021-04-07" version="1">MFDAIVHNVGRVLHGKEDAVRLALLCLVSRGHLLVEDVPGVGKTSLAKALASSVRLEWQRIQFTPDLLPSDVTGSSVFDRDSSTFRFRPGAVFTNILLGDEINRASPKTQSALLEAMEERQVTVDGRTHRLPSPFLVIATQNPVEHEGTYPLPESQVDRFLVRLTVGYPDRSSEISMLESHGSLGPDDLEPVADAGDLAFLSELADGVYVAPPLRGYVVDLAVATRNHPAVELGMSPRATIALQTVAKTMAAASGREYVVPDDIRAVAAPVLAHRLVLGAEAELNATSAEEVVADVLHSVPVPAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV00</accession>
    <name>A0A7K0JV00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidored_FMN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000717">
        <property type="protein sequence ID" value="MST33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="131"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="39897" checksum="BE4637CCA3E8BE49" modified="2021-04-07" version="1" fragment="single">MWRLRARAATRSAAAPARTGISRRPIPVPGPPRRLTHSHYRHDAECRSIPVPVVRGAPFVAFGGQAGDPAVAPSTGHRPPGDGPGAWAGAGSPCGRESARGCWADGRPTCGSPAAGNAAAARDVLFGVSILFSPLTLRGTTFRNRAWVSPMCQYSSTEGRPTDWHLVHLGAFARGGAGLVMTEATAVSPEGRISPWDAGLWSDQQAEDYERIIRFVQHQGAATGVQLGHAGRKGSTARPWEGRGAVPLADGGWVTVAPSPIAYGGWPPPEELTVAGIEAVVGDFRRAAARADAAGFDVVEIHAAHGYLLHQFLSPLTNRRTDAYGGDLEGRSRLLREVVAAVRHSWPERKPLLVRLSATDWADGGWTPEETVAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV09</accession>
    <name>A0A7K0JV09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000564">
        <property type="protein sequence ID" value="MST33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="273" mass="28940" checksum="AF7A92B35DD1E611" modified="2021-04-07" version="1" fragment="single">MTDGSHAIGVPAGLGARLAQQIDGLEALAAETRAVIDRVSGADARRLTERWARAQRIAEGAKLLAAHRAEECAAWKPSGERSAAAWLARLSGCGVGEASRDLEGIGQIAEQPEVADAVVSGEVSVDAGAEVARTANQASVPAGNLLQQARTSPLAATRASCRQARGDASADDEAARLRRIHARRYLRCWTDEEGAGRLEGRFTPDAYAEIRAALSPFANQVFDEHRLAGVHERHECRLADALVLLARAAVDRGVRSPSSSPSGKRSPSTRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV51</accession>
    <name>A0A7K0JV51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">GHK86_13960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000736">
        <property type="protein sequence ID" value="MST33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="377" mass="39769" checksum="6C0DABAB75794AE0" modified="2021-04-07" version="1">MAVDDYYEVLGVPRTASEGEIKRAYLKLARELHPDANQGDPATEERFKLVNLAYETLRDPERRRQYDMFGAGGPRQAAADPFGFGGGAAGGFGDIFDAFFGGGGGFATTTTGRRGPRRGEDVEAVLELDFARAVFGGEEDINVRLPSTCGTCNGSGARPGTTPVTCSGCGGSGEIRRVRQSILGQMVTASPCPRCGGTGEEITSPCPDCRGDGRRTVEQSFVVDVPAGVDEGSTLRLTGRGAGGVRGGPPGDLYVHLRVRPHPGITRDGTDLRTTVHVSMTQAALGTHVGLETLDGTDELTIPAGTQGGREFRLRGKGVPHLQSRGRGDLLVTIAVDTPTELTKTQEELLRQLAAERGEDVADADAGLLSRIRGAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV56</accession>
    <name>A0A7K0JV56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="13"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="20382" checksum="AA0042E11F0C3619" modified="2021-04-07" version="1">MTTTALPATLTGTYAIDPAHSRIGFVARHAMVTKVRGAFNEFEGSGYFDAEQPANSRAELTIKAASIDTRNADRDAHLRSNDFFDMDTYPEITFTSTAVEEVDPGQYRVSGDLTIKGVTRPVSIDFEYTGTAVDPYGNTRIGFEGKTTVNRKDWGVNWNAALEAGGVLVSENVTLEFDVSAIRSADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV2</accession>
    <name>A0A7K0JVV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein GHK86_15230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000833">
        <property type="protein sequence ID" value="MST34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="111" mass="11104" checksum="ADCD04255197C4FC" modified="2021-04-07" version="1">MSGDGSVPDLSALLSQIGQVQQDLQAAQEAATTRVVEGVAGGGLVRVVGTGGLEVQAVTIDPSVADPEDLDALQDLVLAAIRSYLDAVRQLQQQALGGLNLGGGLEGLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW36</accession>
    <name>A0A7K0JW36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000848">
        <property type="protein sequence ID" value="MST34092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029875252" evidence="2">
        <location>
            <begin position="34"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="113"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="511" mass="54457" checksum="7F0AE8D5A34A1368" modified="2021-04-07" version="1" fragment="single">MSARRWRLGAAGACLASLLFAACGSGVNSGGSAGSTGSTGTGGGSSGSSGQSAATTAYQPQHAGGTLRLLWSGAGGTLDPQVNYTLEYWQLYQATYDGLLAFQKTTGQASFNVVPDLATSMPTVTNGGKTYTFTLRKGIKFSNGQPVTLTDVVDSFTRLFKVANPNAGTWYNVIVGANACLKTPATCTLKGGVVTNAATNQVTFNLTQPDPDFEDQLAVPFGSILPASAPTKPGGSNTPIPGTGPYYFASYNPNTQLVMKRNPYFKVWSVAAEPQGYPNEIVTTFGQTVENEVTAVENGQADWMGDPPPPDRLTELSTKYAKQVHVNTLTADWYVAFNTRLAPFNNLKARQAFNWAVNRTATVKLFGGPELGVPACTILPPGFPGYTPFCFYTKPAGSTWKGPDLSLAKKLVQESGTAGMKVALVAQNDTVDYNEGQYLVSVLNAIGYKATLKPLSQNIQFTYIQNTNNHVQISLSQWYQDYPQASDFLQVLLSCANFHPGSDSSINIAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW65</accession>
    <name>A0A7K0JW65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000859">
        <property type="protein sequence ID" value="MST34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="15149" checksum="A412E367FF0C435E" modified="2021-04-07" version="1" fragment="single">RRVGRGRRRRRGGAVLAGWVGRDLLEGCAEAIERDPAFAAAQRWRWRHVFVDEFQDLNPLQHRLLLAWLGDRVDLCAVGDPHQAIYGWNGADPDLLDRFTEHWPTAEVVRLDANHRCSPQIVAAAAAVLGPAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH1</accession>
    <name>A0A7K0JWH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3048 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000934">
        <property type="protein sequence ID" value="MST34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029769524" evidence="1">
        <location>
            <begin position="24"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048" evidence="2">
        <location>
            <begin position="55"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="3">
        <location>
            <begin position="208"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="35373" checksum="3FAE17536F2F2C63" modified="2021-04-07" version="1">MRRRRRLVRRLSAAGLVLGTVGALLAGCGSPARVPAAVARCPLTWLPAPGGVVPRRAALAVKIGNDPAARPQSGLSGADIVIEEPIEGAMTRLIALYQCHQAAEVGPVRSTRWTDTRILGQFGRAGFAFAGGTTPEEDMVRSSPLVDLSVNAVPGAYHRIAGRRAPENLYTSTAALWADVPGRAPPQPVFRYGRPLLTGTPVTAATLAFSSSFAVQWRWDPGRRTWIRWVGGRIDRGADGHALQAANVVIEDVATFPGIVEDALGSRGVNSVTTGHGEATVLTRGHATAGTWSRGSVDEPARLTAAGGRPLVLAPGVTWIELLPVGGVVAGSLALEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ2</accession>
    <name>A0A7K0JWJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000943">
        <property type="protein sequence ID" value="MST34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="135"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="359" mass="37642" checksum="334368417E9B4EEE" modified="2021-04-07" version="1" fragment="single">LPAVRVALLFGGPSPERGISLNSARSVADHLEGPGVELGELIYLDGACRPFPVTRPLLYSNTPDDFDFKLGLSSTPLTPDELAARLRGCDLAFPVLHGAFGEDGGVQRILEGAGVPYVGSGPDACAVAYDKHRCAEHLSAAGVRTVAHAVVDAGDDPAAVGERLAALAPPGTPLVSKPSAGGSSLGVAVHPAGADRVAAILARAGRYGRVVVQGWVDGVEVTTVVVDGPGGPVALPPVEVELRRRSGHEILSYRHKYLPSDDTRYHCPPRFPGEVVDAVRATAERAFAVLGLRDFARIDAWLRPDGEVVVSDVNPISGMEQNSFLFIQAAQAGMTHRGTGRPVEGECPEEEVAVEVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ7</accession>
    <name>A0A7K0JWJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_14550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000778">
        <property type="protein sequence ID" value="MST33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="17204" checksum="495C727976CAD325" modified="2021-04-07" version="1">MRDASGRLDERSKQIIEQLQEDGRRSYAAIARAVGLSEAATRLRVQRLLDEGIVQIVAVTRAEAVGFRRQAMLGVRVEGDIRSVAAKLSDLPEAEYVVICAGQYDLLVELICEDDEHLLQVIDNGVRSIPGVRNTETFVYLRLEKESYQWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK8</accession>
    <name>A0A7K0JWK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000946">
        <property type="protein sequence ID" value="MST34328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5595" checksum="86A7156B221F461A" modified="2021-04-07" version="1">MPTITISWAGSPTRRSLDRAVAERISVAAQETLRRSETAGSVAVELEEPGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL1</accession>
    <name>A0A7K0JWL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000945">
        <property type="protein sequence ID" value="MST34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="28141" checksum="AFE708B0D7AAEBC1" modified="2021-04-07" version="1">MQGPAIDRPPRPVGFPGCRLCPYRDGRRPAVCLACLGASPGQQRVVGLGGRCASCGQARPPGASCPTAWCRRRDRGWSVVFAVGAHCGGLRRAVLRYKYGGERWWAGVFGGVVAAYLDAHAGWFEEFDLLTGVPAYTGPGGRRRWDPVGGILAGVAAAAPPGWAVVPGVLVKRSETPPLSGSGRTDRVEVAGSRLREALRVLRPADVAGRRVLVLDDVLTEGSTLREVALALRIAGAREVAGLVLARTPWAGGAASSLPRAGERPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN1</accession>
    <name>A0A7K0JWN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000789">
        <property type="protein sequence ID" value="MST33959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="20265" checksum="3673D3A6260FBCCB" modified="2021-04-07" version="1" fragment="single">MSIARLRSHWGFTRTPFSKDLAPSMLHRHPGHAEAVARITWCVDEAAIGVITGEVGAGKTVAVRAALAELDTSRHNIIYLGNPAIGARGLYTTIVSHLGQVPRFHRCSLIPQTQEALAAEINERGRRVVIVVDEAHLLAPDQLEELRLLTNADMDSTSPFALVLIGQPTLRGRLRLGAFAALDQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ3</accession>
    <name>A0A7K0JWQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000799">
        <property type="protein sequence ID" value="MST33989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="27808" checksum="63B75F19DC5C53C8" modified="2021-04-07" version="1">MSDPAGQPPGLRPGAVTLAIDVGGTGLKASVLDGGGAMEHSRVRIDTPYPLPPDKMVTVLSDLVKPLGHFDRISVGFPGMVRDGRILSAPHFVSPDGPGGVPSDDLTKAWSRFDLQGALGATLDRPCKVANDADVQGAAVIRGEGLELVLTLGTGLGTALFNHGLLVPHLEFAHHPFRKDLSYNEVVGDAARKRSGHKKWQKRVLEAVDTLRALCFFDHCFLGGGNAARLEGDLPEDVTVVSNDAGILGGIKLWERTVSHPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR8</accession>
    <name>A0A7K0JWR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000979">
        <property type="protein sequence ID" value="MST34391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="13"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="32700" checksum="69E6B754A4BA2D66" modified="2021-04-07" version="1">MVAPPAAARTVLDAIGETPLLQIDGIWVKLEYLNPSGSIKARIAKYMVERAEAEGLLRPGDTIVEASSGNTGNALSMVAAVKGYRMLVVMPDGMSPERTAISRAFGAEVMTVGDFHVNDALAKARELGEQPGWWAPQQFESEWNVEENRTWLGPEVLRQLPDGIVPDAVLGGIGTGGTIVGVGQCFRELDPDCLVAAVEPDESCTILCGEIGRHLIEGISDGFVPGIFARHGHVVDELYAVESDEAVAEMRRLASEHGLLVGPSSGAHLVAARRLRERHPERRNIVTFLCDEGEKYLTDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX36</accession>
    <name>A0A7K0JX36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001048">
        <property type="protein sequence ID" value="MST34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="380" mass="39455" checksum="FBF482DF105F1469" modified="2021-04-07" version="1">KVFKGFTQQTGVKVDMQVIPWSDLLQKILTSVTSGTGPDVMEIGNTWAPSFEASGGFLPFSGANMSAIGGAGKFAKSSLAVSGTPGKPLVSVPVYSEAYGLFYNKADFRAAGISGPPTTWTQLVSDGQKLTTHGRYGIAIEGASTSEAAHWAYLLGEQYGNPLYTHGKWDFATAKEAKAVSLYVNMVGSEHIANPSDAQNDSNVAESLFANNKAAMLVWQNPMSTLGQLGMPASAYGAAPVPAPSPLPAGGKDITTFPAGINLAVPASTKHKAAALALVKYMTSPSVQVSVNQTYGTFPPVLAAQKAAPFQAPTYKALESAYNDHAAPLPQVASESTMETDLGGAITHLIARAATGTHLTTSQIEAALKSAQDQLDTSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE4</accession>
    <name>A0A7K0JXE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001101">
        <property type="protein sequence ID" value="MST34616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16771" checksum="C6E2D46F6FE35B7F" modified="2021-04-07" version="1">MKVSTRGDYASRALLSLALHSAQQPTSVRDVAERTGLPQPYLEQILLALKGAGLVRSKRGVGGGYVLARSPEEITLGEIVSAVDGPIVAGDFGAPHENGACDHEGQCVLLAVWAEVGEHMRRHLDSFTLADMVRRATGNGGADWPWLGPSPAAAPVVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS1</accession>
    <name>A0A7K0JXS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000945">
        <property type="protein sequence ID" value="MST34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="22926" checksum="75FC737F282FADF1" modified="2021-04-07" version="1">MQKLCGVSVIDVSVAVPAGNGVEAGMVVLQEDEPPYRRIQMYVGQPEARAIRVAWRAEIPPRPSTWDLFVSTISLLGGSVEGAVLTDVEEGRHYFAELLLRPAGAAEALHITARPSDAIALVLRCPGASLQAYSPVLDGLAAAAVPPDAEGEVEVEGGPGGGAAPLTGTVHRPGGPKKAVAGGRVARRPPLNADEPVVGEPVVGEPLGSSDIAGSSTVDRAAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT7</accession>
    <name>A0A7K0JXT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF3817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001202">
        <property type="protein sequence ID" value="MST34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="126" mass="13801" checksum="0FA30D4C1F6EC4BC" modified="2021-04-07" version="1" fragment="single">MSQFTDLSTLDGALLRYRVLAYIVGTGLALLVFVGVPLQAAGYPQLVTIAGPIHGVFYIVYLVMALDLARRARFSLVEMFAMIGAGLIPILAFVIERRITRRVRAGAVEPWQLPAFLRRGQSPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV0</accession>
    <name>A0A7K0JXV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001219">
        <property type="protein sequence ID" value="MST34795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8239" checksum="9BD84D5C33A00080" modified="2021-04-07" version="1" fragment="single">MTGRFPGAWAVVVAGGSGQRFGGRKQFAELAGRSVLAWSLDAAAAACAGVVVVVPPGGERAAEVLDQCGVAHTVVAGGTSRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ3</accession>
    <name>A0A7K0JXZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000976">
        <property type="protein sequence ID" value="MST34384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="459" mass="46918" checksum="5DCB03BA1CEE940D" modified="2021-04-07" version="1" fragment="single">MSDSDAGIALNGANLTLSEVVAAARGRVPLRLAPGVRERMAASRSVIEQALAADTAVYGLTTGVAERKRVRIAPAQQAAFNERLIATHRVAQGPPAPADVVRAALVVLTNSLAKGAAGVRPALADALLDVLAQGTAPPVRRLGSVGQADLGPMADLAHGILASTGFRLAENEGLALLNNNAFSAAWSALALADADALLRTMDAAAALDLEAFRANLSVLHPVVDEIRPFPGLVTTLERLRRLLAGSALWEQGTARNLQDPLTYRCIPQIHGAARDALAYGTAVVETEINAAQGNPAVAVAEGRVVSVGNFDAGPTAAAVDFVRLALAPAVGAAAERTVKLLQAPWSGLPAGLAADPGSGDDGLAELGVTVQALAVEARSLAAPVSHELVSTTKGEGIEDRTSMTSLAARRLSEMLDLAGRVVAVELVVAAQAVDLGRPHPLGRGAAAVHDAVRAVLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY62</accession>
    <name>A0A7K0JY62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001273">
        <property type="protein sequence ID" value="MST34880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8852" checksum="29EEE5F36D167EAD" modified="2021-04-07" version="1">MAPDPDDEATPEAPRTPLDPKRVMRVILPSFVASMALAAAGLALFVVGQRTIGLILVVVATVGGLAVRTRLVYREQVRQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY81</accession>
    <name>A0A7K0JY81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar basal-body rod protein FlgC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001285">
        <property type="protein sequence ID" value="MST34897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="2">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="13798" checksum="6E56CA6D07ABB449" modified="2021-04-07" version="1">MFDAINTANTGVDMSQTWLNAISNNLANMNDATRTSQKAYQAEFPVVTALGGGQNGTGSGVAVTGVAHGSAAGITVYDPSSALADAKGMVREPNVDLAQQMTDLIMAQRTYQANVNAISTAEQTYQDGLGLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY96</accession>
    <name>A0A7K0JY96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001302">
        <property type="protein sequence ID" value="MST34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="9599" checksum="932D3125FE9EE92A" modified="2021-04-07" version="1">MPELLRTGVPTRAKVVNVVDERVVGPVTRSRLTLQIEPEGGDGVEVVIRHAFPTPSSRAAVRIGGTVAVRYDRDDPKRVLLDPEADAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC5</accession>
    <name>A0A7K0JYC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMC-Scp complex subunit ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="5" type="ORF">GHK86_19690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001314">
        <property type="protein sequence ID" value="MST34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16398" checksum="3DC0C45D27597767" modified="2021-04-07" version="1">HPDLAAYVERFVLEGQHARLSAAALETLAIVAYKQPISRAQIAAIRGVSADGVLRTLEQRGYVGEVGRDPGPGQAVLYGTTPVLLERLGLDSLADLPPLEEFVPGPEVMDALEQGLRADAAAARNAPPAEEGNAGEEEGTEPAAEEADAADGAGPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI7</accession>
    <name>A0A7K0JYI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphopantothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001091">
        <property type="protein sequence ID" value="MST34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="15371" checksum="133EFFFA63E1CEB9" modified="2021-04-07" version="1">VGDAADLVVMAAAVADFRPEPVGEGKWKKADGPPPLTLVPTPDILAGLGARRRPGQVLVGFAAETLTGEALVASATAKLAAKHVDLVVANDVGAPGAGFAHDTNAAVVVGPTGVVADTGLVDKAVVARVVVDAAADLLAARAAAAADLSPIPQEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK0</accession>
    <name>A0A7K0JYK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_20195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001378">
        <property type="protein sequence ID" value="MST35038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="487" mass="51105" checksum="215B703181DF80AB" modified="2021-04-07" version="1">MTVERPAGPGDPTGGSPGDAGHTLEPLLARAVDLVRRWEAGFGPLPDPPALRPDPDRLERAWQEFETRMQGNHPFFHPRFAGQMLKPPHPVAAAAYLAALLVNPNNHALDGGPVTSGMEREVVDDLAAMFGLPAAHLGHLTSSGTIANLEALWVARQLRPGDRVLHGTNAHYTHGRMCEVLGVPATAVPTDPGGHLDLDAAEAECRRGDVGTLVVTAGTTGLGAVDDIGGALELRERYGVRVHVDAAYGGFFRLLAGTGALTPPVDAALRAIAGADSVVVDPHKHGLQPYGCGAVLFADAGVGRLYAHDSPYTYFTSADLHLGEISLECSRAGAAAAALWLTLRALPLEAATGLGPILAAGRRAALALADRLGTSERLRLHVEPELDIVTYFPVEGEGGGAHGGRRPGPAAVTAASERMLTRGMQGPDPVWLSTLRVDAAAFAARHPDLPAADRPVTILRSVLMKPEHEAWGPDLHRRLEALAAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN2</accession>
    <name>A0A7K0JYN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_20290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001390">
        <property type="protein sequence ID" value="MST35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="41"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="243"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="292"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="581" mass="60406" checksum="FA15F66A8159E8B9" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ5</accession>
    <name>A0A7K0JYQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001419">
        <property type="protein sequence ID" value="MST35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="12920" checksum="182DF47AFEC472FF" modified="2021-04-07" version="1">PRPGRSFALIMDTRPCPGAVELARGADLVVCESTFLSSEADLAHRYGHMTAAQAATLAAEAGARRLVLTHFSQRHPDEQAFAREAATIFPDVVAARDLDVVAFPGALSPDQDAAGRRAPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR0</accession>
    <name>A0A7K0JYR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001398">
        <property type="protein sequence ID" value="MST35067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="20339" checksum="528B5E115F2424B0" modified="2021-04-07" version="1" fragment="single">SVTLGFWVGTGSADEPGPLWGASHFLEHLLFKGTEERSARAISEAVDAVGGDLNAFTTKEYTSFYVRLLAEQLELGLDILSDILWSPAFRAEEVESERQVILEEILMHNDEPSDLVHEVLAEAMWPAHTLGREVLGEEATILAMTREQIAAFHAEHYRPANVVFAAAGDLDHDTVADGVARRLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT4</accession>
    <name>A0A7K0JYT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001445">
        <property type="protein sequence ID" value="MST35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="16616" checksum="5E295D4A2A672752" modified="2021-04-07" version="1">MRLEPGQPAPGFELEGPDGQRHRLDEFLQRGPALVYFYPKADTPGCTAQALGLQGILDDIGTTSVVGISPDPPARLGKFRDKYGLVFSLLSDPDHAVAEAYGVWVERSMYGRRYMGIERSAFLVGGDGSLEQVWYKVSPKATATNLTKALAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT5</accession>
    <name>A0A7K0JYT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA integrity scanning protein DisA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">disA</name>
        <name evidence="2" type="ORF">GHK86_20575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001440">
        <property type="protein sequence ID" value="MST35113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DisA-linker" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="24203" checksum="606CA867AD64592D" modified="2021-04-07" version="1">RHALDSIPRLLGRANQALQTLERYRTRLDAVTSSLSAVEVEDLVTVRDVVTVLQRAEMVRRIADEVEGYIIELGTDGRLVRLQLEELMAGVDDDRQDVIRDYLPDTGAEQVAAAMRALADLPSEQLLDPKAVAQLLDLDHSADLDASLQPRGFRLLGKVPRLPQSAVAEIVDRYGNLQKVMRATTDELEAILGVGVVYARMVKDGLSRLAESSILDQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY6</accession>
    <name>A0A7K0JYY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001480">
        <property type="protein sequence ID" value="MST35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="18000" checksum="AB28253AD8020B74" modified="2021-04-07" version="1" fragment="single">MARLGLGRRRPPAGDYLDEDAAADADPVVPDGPMRMRGREPMYGFATAAVLAAGGIANLLDTTGAGAPPHPVLWPTYAGFVLAAGLVASIRLRNRLLSPFVAIFAAFFLTLERGPNSLSYPHIVVLVVAVGFAVALTMRQRREQRALTPARQPGSRRRGNQPAEDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ22</accession>
    <name>A0A7K0JZ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001457">
        <property type="protein sequence ID" value="MST35132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="13209" checksum="A9B4D7E78DA6981A" modified="2021-04-07" version="1">SPRRGLPDMVHAAAARAAVENLAGGLACDWSRYGIRSVCVAPGNIATEALDGYGPETVASWERAVPLGRLGSPEEVAEVIAFLVSPGAAYVTGATVVVDGGVDVWGHGEPPPLPSPPPVAGETTRRASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ40</accession>
    <name>A0A7K0JZ40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001471">
        <property type="protein sequence ID" value="MST35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="15762" checksum="58373110E942B651" modified="2021-04-07" version="1" fragment="single">MPGTRLVRSPRLADTPYAHAATAASGATGGEGTWVWTAGACPLDRSGRVVAPGDAVAQAHQVVANLRLALEEAGATFADLVKTTVYVATSDRADLVAVWDVVHDAVAESGGHEPPSTLLGVRVLGWPDQLVEGHHDREGVAVVQLGDVDLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA4</accession>
    <name>A0A7K0JZA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001585">
        <property type="protein sequence ID" value="MST35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="69"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="289" mass="31147" checksum="099E0CF29CA97299" modified="2021-04-07" version="1">ALGGDLHAAMRRLAAGHIDATAARIRPSRTWADLVLDPDREAQVREIAIRARHRETVFGAWAFDAQPSAGVVALFAGPSGTGKTLAAEIIAGDLGVDLYKIDLASLVSKYIGETEKNLSRVFETAEASNVVLFFDEADALLGKRSEVSDAHDRYANIEVAYLLQRLERYEGVAVMATNLARNIDDAFLRRIHVIVEFPVPEPPERRRIWARSVPTGAPVADDLDLDALADGVEISGGTIRNSVLTAAFLAAEAGTPITMQLAVTAVRRELQKLGRLASAADFRSLGSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA8</accession>
    <name>A0A7K0JZA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidinol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001295">
        <property type="protein sequence ID" value="MST34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="16501" checksum="52C516BB6F3BB6F0" modified="2021-04-07" version="1" fragment="single">MADLTADLELAHELADAADAITVPASGRSDLVVDTKPDRTWVTEADRGVERAVRERLARARPGDAVLGEEDGLQGEGPRRWIVDPIDGTANFVRRVPVWATLLALEVEGRLVVGMVSAPLLGRRWWAARGLRPEWQRARAVQHAVTVSQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB9</accession>
    <name>A0A7K0JZB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001298">
        <property type="protein sequence ID" value="MST34914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="34361" checksum="00D69CA45EE3D89A" modified="2021-04-07" version="1" fragment="single">MSADPLDLLVGGAGPAGLTLALQAAAHGASVRVVERRADPARPSRALVVHPRTLEVLRPLGVTDELLARGDPAPAVRLHLGRREVEARLGAFPLEDTAFPFLLFVSQSAVEEALAGALARQGVEVERGVELTDVADCTGTAVARVRRRSVAEFVDCRYLAGCDGSASRVRAELGVAWRGAPYREEVVLADLELAGDLEAGRSHAAAARSGVVFVFALGEGAPWRLLATRPAGPDRGRPGQPLGPVRREELQAILDGARLGAVVTAVRWSARVPLEHRLASRYRRGPAFLVGDAAHVHSPAGGQGMNTGIQDAANLGWKLAFAAAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC7</accession>
    <name>A0A7K0JZC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001306">
        <property type="protein sequence ID" value="MST34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029911249" evidence="2">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="20547" checksum="CE5FE70B9709D8D8" modified="2021-04-07" version="1" fragment="single">MLGVIAGVVTAKPPAAANPLKTPTTVAPNEYSATALLMPVAAGAPAAQGDPSGLSLSAMAFFATTGDVPRMVAQQLGYRGNPADLASQVSVTTNNTVGVLQISANEPTGAEAVKLVNAFAGQLINYLDNQIKQSYARQRTQANAQLQALSARIASLQQQGSSAVTQAVISALQAQYKSDAAQYAQLQGNPPKTDLTVIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZP7</accession>
    <name>A0A7K0JZP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001657">
        <property type="protein sequence ID" value="MST35353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="8354" checksum="59223C5B2F4C0EE8" modified="2021-04-07" version="1" fragment="single">MPSGGRSSGGTTTSSTTGPAVTTAQVKLVSSSVGVSVYQVPKATPITLVASGPCWVEARSGDTTGPVVFTATMQAGATQRLTGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZY8</accession>
    <name>A0A7K0JZY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001453">
        <property type="protein sequence ID" value="MST35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="134"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="295" mass="31059" checksum="1F221F641891263A" modified="2021-04-07" version="1">MTAPPRVDDGEVLAQLDSLLPSLSPSEQRVGRVILEDPARAARLTITDLAGLASTSETTVIRLCRSIGVGSYPNLRIALATAAGRSGLDQGMPRSPDISPDDDVAAVVAKIGATHARAITETVANLDTAELESVVAAVVAARHVDVYGVAASGYVALDLQQKLHRIGLTAYAWSDPHMALPSAANLGPVDVAIGFSHSGTTIDTIDALAQAREVGARTVAVTNFERSPIVRVADHVLRTSVSETSLRSAAMASRIAALTVVDCLFLGVAQQRYATTVDALDRTRASVRSRHRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K042</accession>
    <name>A0A7K0K042_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001482">
        <property type="protein sequence ID" value="MST35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="30775" checksum="2F1A9F6CCE59547E" modified="2021-04-07" version="1">MSLTDRLAGALERRVSRRSFLVRSTFAGSALAAGRARWLVEPRSAYHELCNSVYCGSSACSCSSTCCAGYTEFCCTLDGGYNSCPPGTVMGGWWLAEGSVYCDGPRYYMDCNAVCHCSAGCGSFCDPGCDGLSCGCAEGSCDHYLTGCFQFRYGQCNQDVGCIGRIHCRVVTCVPPWEIDPSCTRTLATDDFTADQDAACLGPDPTYPPPPFAFRLEEVMFIAKDSESATQWFVSGNTKVPIHSAADLQVYRRVLEKAGLDDTTHILTAGQLKLIPTAVPAAGAAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMF6</accession>
    <name>A0A7K0JMF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_00080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="436" mass="48059" checksum="4B0F777A765A1020" modified="2021-04-07" version="1">MPVGGEKERPVAHEKETATVTSQISGLEWELPGMWNRMFESRVLRDHGTAELQRISALEGGESLEWCYGCGKCVPVCPVDLVGEYGPRKLHRLAQTGTNLLADDRLWLCTTCGNCLRVCPKQVDMIQIAPAAREAAVGAGHVPTELQDVFEKTFRQGNCLGENPRRRHAWTRGAGVPVRVLPSDPSPVDVLFYVEDYWSYHPRGQQAAQALARILTVLGIDFAILGPEEKTLGDSQRLAGERGLFEALMEDVVATLAKYEFARIVTPDPHGFNALRNEYTKRGHHYEVAHYTQLLAPLADRIPWSKSIDARVTFHDPCYLGRHNGEYDAPRRLLQSIPGVELVEMGRCRENGYCCGGGGGGMWLDGLTAGRTTERLSERRVREAAETGAEILAVCCPYEVSRFEDAAKSTGNEQLQVLDIVELIDRAMAGGSAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMM0</accession>
    <name>A0A7K0JMM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000017">
        <property type="protein sequence ID" value="MST31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCV_T" evidence="1">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="2">
        <location>
            <begin position="299"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="373" mass="39595" checksum="822D37CC702A74DD" modified="2021-04-07" version="1">MPAPAELLATPFSAHYPAGIEEWIDVYGYAVPLTFGDPLAEYTAVRTAVGITEYSMLYKWHVTGPGAVPCVDAIFSRSVTSQPTGRISYGVIVTDHGCMVDDVTVAVHRPDLVVVTGGNPDTAHHLAAAAPEGTTVTERRSETAVLSLQGPRSREVLQTLTTTPVDNHALPYYQFRTDLDLAGIPAQVNRLGFTAELGYELQVPVERAGDLWHAVTDAGQPLGLRPFAAAALMMCRVEAGMIMGGLEYDERTSPYECRMGWAIDLDKGPFQGREALAAAKDTAPTRLVSINLGPGQSDADGVTLHHEGVPVGHITMAVPSPHLGGDLLALARITPTAAKVGTALTAALPDGTTRTGQVVATPVYDPQRSRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMQ1</accession>
    <name>A0A7K0JMQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHOCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000006">
        <property type="protein sequence ID" value="MST31147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029582250" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="3">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9385" checksum="1EDD87BAB4A16F9B" modified="2021-04-07" version="1">MPRLLRGVARTAVVAGTATAVSNRVSRRQANRWASDDQQAPAPQQDQQAAASPPRDPVAQLKELGELHAQGVLTDEEFAAQKAKILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV2</accession>
    <name>A0A7K0JMV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">kdpA</name>
        <name evidence="10" type="ORF">GHK86_00910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000032">
        <property type="protein sequence ID" value="MST31292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="563" mass="58885" checksum="986CA34DD55C5AD4" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW3</accession>
    <name>A0A7K0JMW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000029">
        <property type="protein sequence ID" value="MST31278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="20209" checksum="4BDAA22C58B02A10" modified="2021-04-07" version="1">MRQGLPTPELQIGPRLRRARLASHLTLEDVARSTGLTKGFISQLERDMTSASVASLVKVCEALRISVGALFEPASTLLTRSAEAPRINFGGTGLLEVLLTPRGSSDLQVIRSVIEPGGGSGEEPYGLDAKAEVAYIVEGELVVALDAEEYRLAAGDTLTFSAQVPHAWHNPSKRRRAVALWILAPSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN73</accession>
    <name>A0A7K0JN73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000034">
        <property type="protein sequence ID" value="MST31301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029561896" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="110"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="612" mass="66764" checksum="257F2B8051D011D8" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNA0</accession>
    <name>A0A7K0JNA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="23924" checksum="8C32EBABD1C33705" modified="2021-04-07" version="1">MLFVRHGTTPTTGQVLPGRAKGLHLAEAGRDQAATVAGRLAEWTGAGLAAPIPPRGAGRGPGRSNKAPKRPAVTAVYASPLERTKETAAPIARALGLPVTAERGLLECDFGAWTGAALKDLAKLPEWTTVQRYPSGFTFPDGESFVAMQRRMIETVANLCSRHRGETIVAVSHADPIKAVVADALGTHLDLFQRIVISPCSVTAITYGGTGPTVLAVNSTGSLGELRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNC4</accession>
    <name>A0A7K0JNC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="3">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000060">
        <property type="protein sequence ID" value="MST31403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="22493" checksum="009975684CDED3E0" modified="2021-04-07" version="1">TDMVSEVDRGAERLIADLLAERRPDDGLLGEEGADRPGTTGVRWVVDPLDGTTNYLFGVPAWSVSVAAELDGVPVVGVVVDPSRAETWAAVAGRGARCNGTVCRVAEGRSTTATALVGTGFGYDPQRRAAQAEVLRTVLPAVRDIRRFGSAALDLCWVAGGRLDAFYELGLNAWDAAAGTVICREAGGVVDTLDSGVLLAATASLAGPLRDLLGSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNC7</accession>
    <name>A0A7K0JNC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="17475" checksum="A683FEB1B039C842" modified="2021-04-07" version="1">MTESLVKSVNHIGLTVTDLDRSLAFYTEVLECSVVMRQEKKGGYLAAIVGYPDAEVSMAHLRMPGADQRIELFEYRVPRSVERELEPCNVGNAHICFVVEDLDRMYERLVVRGVQTISPPVAVDTGVNKGGAALYLRDPDGITIEIFQPPHRIEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF9</accession>
    <name>A0A7K0JNF9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LytR_cpsA_psr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000053">
        <property type="protein sequence ID" value="MST31381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="110"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="522" mass="55120" checksum="C195B99BE9D850CA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG1</accession>
    <name>A0A7K0JNG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000086">
        <property type="protein sequence ID" value="MST31506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="13535" checksum="8233106B68E95CB1" modified="2021-04-07" version="1">MAQKVQVVLTCDLDEEEVPAVQTVTFGYDGYTYAFELCEQHLEEVNEIFQAWIGAARLADGGRRRRASAATAAPSRARRSGGGGGGSTNGSGDIRTWARDNGFSISERGRIPAEVRRAYEEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN5</accession>
    <name>A0A7K0JNN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000099">
        <property type="protein sequence ID" value="MST31576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="44"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="558" mass="61638" checksum="EA2311A3AE456639" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN7</accession>
    <name>A0A7K0JNN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="29321" checksum="911E0983265001E1" modified="2021-04-07" version="1">MPAPTLRGLEGKVVLITGAGRGQGANHARAFAEAGCSVAALDICAPIPDLYDTATADDLALTAKEVEAAGQRCVTLVADIRDEEAVRSAVSATLEQLGRIDILINNAGMAALDRIGDMRASTLDAVIDTNLKGPMWMAKYVVPHMVGRNAGNVINISSAVTGNGNAMLSHYVASKYGVIGLTKSWAFELAEYGINVNAVCPATIKPGTGHGSGMVRGLADFLGMDPLEAYDMWNKVGNLPGPKWAAEMQDITDACLYLASDNARMVTGHVLYVDGGQATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN9</accession>
    <name>A0A7K0JNN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000098">
        <property type="protein sequence ID" value="MST31568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="83"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="524" mass="56499" checksum="17503E3525051145" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP2</accession>
    <name>A0A7K0JNP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NERD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="2">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="313" mass="34449" checksum="713425C0181DF9D0" modified="2021-04-07" version="1">MLDLQRMAGVADKAVVRTLTLRRADSCVCCGSNLAVGDRAAWDSVAKTVTCLPCLNSVPVAAQPTGEVEPSLDPRALERGTAGKSVAREAARRSERHRQRQEHRIAADREWRARVKAQRPITGRLQAALTPKVRAQPVPQHVQSWVTGTPGEQKVGEALDAIAGIIALHDRRKPRTRSNIDHIAVTPAGVWVIDTKVRTGKKLEFRDRGGLLGRDERLIVGGRDETRMVGDMAWQVETVQRAGAELLSDIVVRPALCFVDVTLGLLDRRPWTVKGVAVCWRASLPDLLLRPGPLDDRRMTEIADRIISRLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU3</accession>
    <name>A0A7K0JNU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="111"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="225"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="429" mass="46675" checksum="9114DE61AEA13967" modified="2021-04-07" version="1">MAGRHQPDRSRRAPLLRLEVHGRQVGGEGAKPAGADPEDREGPRPRRHPGGRAMKGSTLKRGSTWTAYWSVKDPGTGKRVQHSRGGFRTQRLAQEHLTEVLAKVNKGEWRPDTQLTVQALLLEHWLPSRRASLRPSTVSLYRRAADDWIVPNIGAVELRRLVPATADQLAAKLATSGGKGGMPLSPRSVQIAVGTLMSATRWAAKTGLVGRDPLTGHDRPTASSPEMKAWTAEEARRFLGATSGDRLAFVYALLLTRGMRRGEVCGLRWEDIDLEGGYLRVVRTRVLVDGRPQLSEPKTKAGRRSVPLDPKLVALLRRHKAQQAAEKLAAGTAYHEAGWLVADELGRPYYPDAVSGMFDRQVQAVGLRKIRVHDTRHTAATLMLSDGVPVKTVADLLGHDPRVTLATYAHAVPGLGEAAGAALSARLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP49</accession>
    <name>A0A7K0JP49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-activated pyridoxal enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000040">
        <property type="protein sequence ID" value="MST31339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14648" checksum="9C6F96259D938ABA" modified="2021-04-07" version="1" fragment="single">MELDALTTPALVLDADVVEANLAAMSAALPGSRLRPHVKAHKCTELARMQAAAGHPGFTCATVREAEGMARAGLGGDLLIANELFAADRVGDLVAAGHRVTLAVDSPETVRAARDGGVREVLVDVDVGLRRCGVRAEQAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA7</accession>
    <name>A0A7K0JPA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000056">
        <property type="protein sequence ID" value="MST31389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="32500" checksum="D44E5307EC467D68" modified="2021-04-07" version="1">MTALLQPADAPPVEDQAPRQGSNLRAALRAFLRNRLGVLGALIVVGMALFCFVGPLVYHTDQIHTHLNQVHLPPSAGHPLGTDDVGYDVLGRLMVGGQSSLEVGVAAALIATAFGALWGAVAGFASRWADSVMMRVVDALLSVPPILLLLFLATIHRPSVPLLILVVSIVSWLIPSRLVRGEVLVLRERDFVRAARLFGVKRHRIIIRHLIPNSIGTLVVNASFQVADAILLLASLSYLGLGLPPPAADWGGMLSNGINYLYSGYWWLVYPPGVAIVLTVVGFNFIGDALREALEVRLRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE4</accession>
    <name>A0A7K0JPE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="347" mass="37851" checksum="8C2E443D637F9CD2" modified="2021-04-07" version="1">MSHKVKLEPVGIEMDVEEGETILSAAFRQGLMLMHGCKEGQCSACKSFLLDGDLDMERYSTFALADYEREEGYVLLCRSHAYSDLEIELINYDEDMLHSGLPVREALAEVRAIDVLTHDIRRLVLGLVEPADLAFRAGQYVDLTIPGTDHVRSFSMANTPASAGVLEFLIKMYPGGRFSSLLAGELSVGDRLRLEGPYGMCTLRPSSERDLVMLGGGAGMAPLLSLLRSLAETRSGRRIRFYYGARSRSDLFYLDELADLGRRLPGLTFVPALSAPAAGDGWEGETGMVTDVLDRHEDDLGSFEAYLCGPPPMIDAAVPVLIGKGIDESRIHFDKFTVSAEAGSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF2</accession>
    <name>A0A7K0JPF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000150">
        <property type="protein sequence ID" value="MST31825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="16932" checksum="57C856824D618C6F" modified="2021-04-07" version="1" fragment="single">MGTLDEHGRPEPPLQADEEATLVGFLEWQRSTFAWKCAGVDAAGLDVTVGSSSMTLGGLLKHMALVEDYWFSEQLLGRDAAPPWNAVDWEADRDWEWHSAADDTPEQLRALWEERVARSRVALGEALEAGGLGGLVRRPPAGVEPASVRWVLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ0</accession>
    <name>A0A7K0JPJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">groL</name>
        <name evidence="9" type="synonym">groEL</name>
        <name evidence="12" type="ORF">GHK86_01785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000071">
        <property type="protein sequence ID" value="MST31464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="540" mass="57107" checksum="97D8C0D6EAE55A69" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ2</accession>
    <name>A0A7K0JPJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000146">
        <property type="protein sequence ID" value="MST31821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="15966" checksum="22CC5AA437A97D18" modified="2021-04-07" version="1">ALPGDDAGWDALALEAVRSARSAGRLVPGLGHPVHKVEDPRTPVLIRIAEEEGLRGPHLRLFEAVGRVHDQVLGRRLPLNGAGVCGAALADLGLPVELLRGFALLARAAGLLGQLAEERRRPIGMDAYLAVDRNAVYVEPDQEDPAWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ05</accession>
    <name>A0A7K0JQ05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_04590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000195">
        <property type="protein sequence ID" value="MST32003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="66"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="36276" checksum="711515FFFD4EBF50" modified="2021-04-07" version="1">LPPVVPAHRPPAPLAPPRQRAARRPQPGPCLSIRPHHHYDAPDDVALGTAPAVTTLAEYRTSRELFNNLALRELRSKYKRSFLGWAWSLVNPLANTLVYTVLFGVLFHAQPPNGGPSHLKVYALYLLCALLPWNFFQAGVMGSVGSLVGNGNLIKKTYFPRELLPASTIGAALVSHLIEMGLLLVVLLAFGDYWALEWLPMTVVLIFIITIFGLGVGLFFSVLNVYFRDIEHFLGIFFLLWLYATPVVYPTDLVSKHHFPGTHINALRILEINPMTEMASQFRATMFYGGAPDWKAVLYLAAWAFGALAVGLRVFSRMEGRLAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ84</accession>
    <name>A0A7K0JQ84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="378"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="578" mass="61985" checksum="4A6D91594E154EDD" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE4</accession>
    <name>A0A7K0JQE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoicase</fullName>
            <ecNumber evidence="4">3.5.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">alc</name>
        <name evidence="4" type="ORF">GHK86_05405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000226">
        <property type="protein sequence ID" value="MST32162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="33147" checksum="00BA366E73E3E82F" modified="2021-04-07" version="1" fragment="single">MTDRPEPTDDIGHVGLAARLLGATVVAASDEAFGEKEHLLDAAPVDFQPGRYGPRGEIVDGWETRRRRSPGHDWAIVRLGLPGRIASVDVDTTSFTGNFPPECRVEACGLEGYPAPATLSGDGARWHEIVPRSPVRGDGHNVFAVADPRRFTHVRLSIFPDGGVARLRILGEAIPDPRQVDGVSIDLAGQQHGGQVVDSSDGFYGSASTLNRPDEARTMGEGWETQRRRDGGHDFAIIRLGYPGAVQQAIVDTRHFRYNASAAVALWGYRPGPRPALRAPDWRPLLPHQRLEPDTRHVFEVADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF0</accession>
    <name>A0A7K0JQF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000233">
        <property type="protein sequence ID" value="MST32178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="165"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="348" mass="37459" checksum="60B471F766FD6066" modified="2021-04-07" version="1" fragment="single">MPWSSGTKGRAPSPDRTDAPSRSCGATPRSGARPDPGHRPGSPVPGESPDRAGAPGVDPEVSGAGPEHPSVGAALRRIEKNDLSAPARIVEIERTEVAEEGIDVSSARTLWCLGKDRGVPSQLSFWDVSDDESVLPRSLASPLPHRPPGSVAPVASPLSRALTLTICVCTRERPDEVRRLLAHLEDQSDRDFEVLIVDNAPTDGATREVARDPTSLGVRYEVEPVRGLSRARNRGLTESSSDLVAWLDDDERPDRHWVRSLRAGFDHPCRPAAVVGSIFPAELETPAQVLFETYGGFNKGRGLAPEVLRRHTSRVRSALYPSPSLGSGGNMAYLRRELLSIGGFDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP0</accession>
    <name>A0A7K0JQP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="5">2.3.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000171">
        <property type="protein sequence ID" value="MST31904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="19579" checksum="CBDFE1E16D252531" modified="2021-04-07" version="1" fragment="single">GILPLEGLRVTRSLRRAAARYEVRVDTAFPEVIDACADARRPGAWIDAAVRDAYTRLHRLGWAHSVEAWDDAGLAGGLYGVAVGGLFAGESMFHRRTDASKVALVGLVDRLRAGGGRLLDVQWATDHLRSLGAVERTRDEYHRLLDEALAAPQLRLDGAAPPPDCREAGAGGTGGTGGTGEAGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV0</accession>
    <name>A0A7K0JQV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000262">
        <property type="protein sequence ID" value="MST32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="261" mass="28247" checksum="B668E80E5A0962DD" modified="2021-04-07" version="1">LYFLLLTFQLYLVFPPLMRWLTAHPRSHRPLVLAAFAFQLAFTGAIHYRWDPPVLGIWLTHAGSWLPSYVLYIVGGLVAALHFDAVTGWVRTHGRLIAVALVASVALAEVSYVCDLRYLGFSPIHAGGVFQPTVTIEAVTSTLALYALGLWVIDRVADRGRRFLERSADASFGVYLAHPLLVGGILDLAAVTGLDAAVGRLPGGAVEALAVFALVPFVYAVTFTVITRIRRTPASLWLTGRRAPHPARADLTAATASPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR21</accession>
    <name>A0A7K0JR21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="18350" checksum="743312A91A16152A" modified="2021-04-07" version="1">MTDPFAAFLHPVEPSDYDEIDIPAPTRWAAIPAEDAPQAWAELRAWAEQLRERFCLDHHVLPACWWRHNPHVEALAALRDHEAASYLDTAPATAPVDWLRALRDVTALLRAWTGELGCDATHRPGPDTTTAGAAFDEAGWAAYVAADTSRRRSSPQRGETDEGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR75</accession>
    <name>A0A7K0JR75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3418 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000290">
        <property type="protein sequence ID" value="MST32431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3418" evidence="1">
        <location>
            <begin position="1"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="488" mass="53118" checksum="30920B1F5D8A0C6B" modified="2021-04-07" version="1">FDRWWRDARRSEPDRMTLRPADYVRPGAGRIRFEDYPDVWVVGGLRLALAYRYAPLTEEDGVTVAVPLAALPRLADDELSWHIPGYRSELVAALVRQLPKEARRLLGPVPEAVAEFLAARGPGEGDLHDVLASWVIARTGAALPTRLWDRPEDLPAHLRPRFAVVDGRGRELAHSRDLGALRQRLREPLRAAIAGAASSYEHPPETAWRFGTIPDRVEVTVAGQELAAYPGLVTEGAAVAVRVFARRAERDAAAGPATRTLLLLGTNPPTARATRSLPQDAKLALAHVPHASLAAFLEDCAGAAVDQLLEAAGGPVRSEPEWAALLETVRHGLADATTRAVTRAALAVSFHRLAVTRLDRLAEAPTMVLPVADMRAQLRRLVGPGFVTRTGTARLIDVVRYLRAVGARIDKLREDPRRDRERMQRVQALEAALTVAGGGAGFTGDAGVDAVWWMLEELRVGLWAQSLGTAGPVSEARVRRAIDRLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR91</accession>
    <name>A0A7K0JR91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orn</name>
        <name evidence="3" type="ORF">GHK86_06875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000293">
        <property type="protein sequence ID" value="MST32442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="20446" checksum="0E3A5E889DBE5183" modified="2021-04-07" version="1">MLAWMDLEMTGLDPRVDRIIEIATLVTDDDLQLIAEGPDLVVAAPAERLAGMDDVVRAMHTRSGLLTAVESSTLTLEEAGAATLAFLREHIPAPQTVPLCGNSIGTDRRFLAAWLPDIESFLHYRSIDVSTVKELARRWYPEALSGAPRKGGNHRALDDIHESLAELRYYRGAVFRQVAGEDRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB7</accession>
    <name>A0A7K0JRB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000304">
        <property type="protein sequence ID" value="MST32471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="63"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="26784" checksum="8C5F750969FF3649" modified="2021-04-07" version="1">MATSDPQTSTRAVPRGQEANVRSQRRRWTRAVDRWDHHGVVGLEKIIAAVVAETAALHPDLAVDVGAGTGAIALPIAASCKRVIAVDVSQAMLDRLAERAAAQGVTNLETVAAPAEQLELEPGSVDVVVSNYALHHLLDADKRQFVHQAATWLRPGGSLVIGDMMLGRGADSEDRAIIAQKVTLMLKRGPGGWWRIAKNAYRMATRTSERPISMQAWTRLLEGAGFVDVTGRRVVNEAGLVIGRRPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC3</accession>
    <name>A0A7K0JRC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000313">
        <property type="protein sequence ID" value="MST32496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="25710" checksum="9A8CE4D38035A605" modified="2021-04-07" version="1">MEARIGFGVDFGGSGIKGAPVDLATGELAGERFKLATPQPATPEAVAGVVAKVVSHFGWEGPVGATFPGVITGGVARTAANVDPSWIGADVAEVLADAAAGPVVPVNDADAAGLAEVVWGAARDHDGLVLVVTLGTGIGTALVHRGRLVPNLELGHIELEGVDAETRASAAARERERLDWPKWSKRLQRYFRALEDYLWPDLIVVGGGVSRRAEKFLPLLQLRTPIVPATLENRAGIVGAALLATPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF5</accession>
    <name>A0A7K0JRF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000230">
        <property type="protein sequence ID" value="MST32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="18112" checksum="33610FA8A75E0C23" modified="2021-04-07" version="1" fragment="single">MLAHFLFVVDQVQIGAFNEVSGLEMRAETVSYNEGGENGFVHQLPGRMTWPNVTLKQGVINNDNLFAWVGKTSGPGFAGAGNKVSRCTGSIYLMSMDGTHYIRRWDLSGVMPIRWTGPRFALSSNEQAVEELELVHNGFTSSVGVRPHHRPVLLAAVPARCRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH5</accession>
    <name>A0A7K0JRH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MR_MLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000324">
        <property type="protein sequence ID" value="MST32535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="397" mass="42195" checksum="6CF30E17C74C0750" modified="2021-04-07" version="1">MKIVDVRATPVAVPFVAPLRWSLGVCTHAVRTVIEVETDDGIIGVGETSGADAAAAVDAHVAPLLRGQHPMLTTRILQALGAGLNLPYTLPQSVFAAVEMACLDAVGRSFGVPVHSLLGGSVRDAIDVCAIVYYRHAAGATTDEVLDEEALCERVGDLAAATGAPVLKLHGGVRPPREELHLLSLLQERTPGARWRLDPNGAWAVATAREVARSLPETRVDIEYLEDPVAHLEGMAQVRRDSPVPLATNMCVTGFADLAPGIRLGSVDVVLADVHYWGGLRANQRMIAVCDAFQLGVGLHGHAELGVSLAAMVHLAAASPSMTYAIDVQRFDLAGDIVQETLPITEGRLAVPSAPGLGVELDHDAVERAHRRYLEQPTGDRIEDPRPASWGVTIPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL0</accession>
    <name>A0A7K0JRL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000328">
        <property type="protein sequence ID" value="MST32553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="4">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="8921" checksum="FEB0DE8538970589" modified="2021-04-07" version="1" fragment="single">MLVELRVRDLGVIDDQALLLGAGMTALTGETGAGKTLIVEALGLLVGERADPLLVRPGADEALVEGRFAAEPDAAGDAGAGERILARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM4</accession>
    <name>A0A7K0JRM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recF</name>
        <name evidence="10" type="ORF">GHK86_07580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000335">
        <property type="protein sequence ID" value="MST32582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="364" mass="38757" checksum="7E74BBB81139BCBD" modified="2021-04-07" version="1">MQLERLWLTDFRNYAAAELHPAPDGLTVVTGANGEGKTNLLEAVGYLATLRSFRGAPGEALVRAGAPVAVVRAEARRDGRGLLLEAELHPTGRDRVQVNRQPLKRTRDLLGALQVTVFAPDDLELVKGGPAARRRYLDDLLVALHPRHDATQTELDRVLRQRNTLLRQAGGRATPDVVATLEVWDAKLADAGEKLVTARRGLTAALEPLVSSAYAQVAEAARLRGSHVGVRLAYQASWEGGLAAALAAARGDDLRRGVTTVGPHRDELGCWIGDLPARTHASQGEQRSLALGLRLGGHRLVAERIGSAPVLLLDDVFSELDADRSAALLDALPAGQALLTTAGSPPPGAEARHVVRVEGGKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ5</accession>
    <name>A0A7K0JRZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_08275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000367">
        <property type="protein sequence ID" value="MST32716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029652996" evidence="5">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="56"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="28516" checksum="CEF7A005FDB9DDBD" modified="2021-04-07" version="1">MSLAGFVVVVAVVGPFVAPDSPTAFVTTPFAAPGGANVLGGDTLGRDVLSRVLAGGWVLLIMAAAATAFGVVVGSVAGVSAAYLRGRADGFIMRTVDVILAFPQLVFALLLVSIVGPKPWLIVLAVGFTHAPAVARVLRSATLDLSERDYVKAVELQGMKPSKVMRSELLPNLVSPLMVEVGLRLTWSIVLMAGLAFLGFGQPPPAPNWGYMIQENRIGLSSNPWSVIVPAALIAVLTIGTNTFTDAIARVMIGVDRQGDDATLASVISTAGSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS01</accession>
    <name>A0A7K0JS01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000370">
        <property type="protein sequence ID" value="MST32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="214" mass="23008" checksum="DDCE3E9D45A80A7D" modified="2021-04-07" version="1">MPAGSVAAVADVDGRVARRRRNREAVVEAALNLLEEGVLDPSVEQITERSGVSPRSVFRYFESLDEMRSAVLRRNEDRMKEWLAPVPAGGSLEQRVVHLVSGRVAMFDRVAGVARAARLREYQVPGIAADLARVREALRAQALGAVEPELRAKDEAAASETGAAIDVLLSFESWDLCTRVQGMAADQVRRVWGRALVGLLAAQPANAAAGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE0</accession>
    <name>A0A7K0JSE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_08975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000409">
        <property type="protein sequence ID" value="MST32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="49"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="387"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="419"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="630" mass="68107" checksum="D9EFC24E6BC6F3F2" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF1</accession>
    <name>A0A7K0JSF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF929 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000417">
        <property type="protein sequence ID" value="MST32876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009272">
        <property type="entry name" value="DUF929"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06053">
        <property type="entry name" value="DUF929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="391" mass="41422" checksum="ED6B27B7D54E412E" modified="2021-04-07" version="1">MRGVYRWSWPATPRPGARCRRGRMGQAPGAAGLQRLHRYHLSTVATADNDSPQRPSATPVPPRGGKKKGPARPGASSSRSGGARPSASQRSANNRRAAVAAQRRRRNMLLAITAVGVVIIVIAVLVIVKVAGGGKTNVAVGSGINQPVTAAQYNELASIPASTLARAANNFHDTSSTTPLTYPQPIKGPAYPVDGKPGGFYLGAEYCPYCAGERWAVVLALSKFGTWSGLQTMKSSSTDVFPDTPTFTLLKAKFASKYFGFDHWEQETRTYKPLQTPSATANKLFGKYNLQQGIPFVYLDGKYLINEIQYDDAFFRPGGGQNTPGMSFKAALASVTSGSTALSAHVEAAAGSIVADVCRITHGQPGSVCKYFPKAITSPDVTPGDLATSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF7</accession>
    <name>A0A7K0JSF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000412">
        <property type="protein sequence ID" value="MST32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="20586" checksum="5DA235FD4232C13E" modified="2021-04-07" version="1">MRRVTYSMGMSLDGYIVGPDGTLDWAAPDDEVFRFVTDEIRGVGVHLLGRRLYETMLYWETADRDASLNDAELEWAALWKALPKVVFSTTISAVQGNARLASGGLAAEIERLQGEAAEGDIAIGGATLAAEAAAAGLIDEYRVRVHSVLLGGGIPFFPQRERRVDLQLLETRTFRTGTMWLRYAVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG0</accession>
    <name>A0A7K0JSG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="24864" checksum="006640410FCD7498" modified="2021-04-07" version="1">MSKATALVTGATSGIGRATATLLAAAGWDVWVTGPDAAQVEATATQLSCRPLPMDVTDRAGVAAAAKAVSNLDVLVNNAGISPDPEVPLTDAGAELFRRTYEVNVFGVVTVTNAFLPVLRRSPHPRIVNLSSGTSSLAWSTAPNPQFDHHQAAANNGRLAAYRSSKTALNALTLLYAQALADDGIKVNALAPGIRATNLNPTAAARGGDPAEAAAAIVRLAELPDDGPTGQVFSYDGTTVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG7</accession>
    <name>A0A7K0JSG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribulose bisphosphate carboxylase small subunit</fullName>
            <shortName evidence="3">RuBisCO small subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbbS</name>
        <name evidence="6" type="ORF">GHK86_09130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexadecamer of 8 large and 8 small subunits.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuBisCO small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000418">
        <property type="protein sequence ID" value="MST32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03527">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00859">
        <property type="entry name" value="RuBisCO_S_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024681">
        <property type="entry name" value="RuBisCO_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000894">
        <property type="entry name" value="RuBisCO_ssu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036385">
        <property type="entry name" value="RuBisCO_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31262">
        <property type="entry name" value="PTHR31262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00101">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00961">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55239">
        <property type="entry name" value="SSF55239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="2 3" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_small" evidence="5">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="16586" checksum="D7E2116E9116BAB1" modified="2021-04-07" version="1">MRLTQGTFSFLPDLTDDEIRAQIQYCLDKGWAVSVEFTDDPHPRNTYWEMWGLPMFDLADAAGVLAEVVACREAFPERYVRVMAYDNSLGRQTVALSFLVQRPTEEPGFRLERSEGPDRRQRYDLRPYALDRPAGERYGSAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ1</accession>
    <name>A0A7K0JSJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000430">
        <property type="protein sequence ID" value="MST32916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="32153" checksum="C29759AAA43618CB" modified="2021-04-07" version="1" fragment="single">MAAEPQCGAPPAPPSRATCPSHGAALDGIGGWREARRVNGRSSEVRPGEGGAAGGDPAAAGPLTGLLVADFSRVLAGPYSTMLLADLGAEVVKVESPGGDDTRTWKPPVRGEDATYYLAVNRNKRSVVFDLKDDADRAAAQELARRADVVVENFRPGGLARFGLDYDTVAAANPRVVYASISGFGSAPAGAALPGYDLIVQAISGLMSLTGSPDGEPYRAGISVFDVMAGLHATIGILAAVEMRHRTGRGQHVEASLLASAMSGLVNQTSAWVAGGVVPYRMGNSHPSLFPYEPLPCADGDLIVTAGNDGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX5</accession>
    <name>A0A7K0JSX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000459">
        <property type="protein sequence ID" value="MST33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="37849" checksum="39536D0C5CEFB78C" modified="2021-04-07" version="1">MRLPQPMSLLAFQLAGLQATGSIGKGALLVGITGFCGLLGPWTGRRRDRGSMRRRLQGSCLAGSAALAGMGACVHWHGPYGLLVVLAVLQGSAIAGMWAGFRALLVQVAPHDKLRQAHFVESFMVEVSFAAGPLLVMGVVRLEGVAGALICMAVGELAGGAILFGVPDLRGVGAAAGSRVRRFAPGVRRPVLAISALAFVLGLGFSMIEANVPARMAPYGLPPSAAGTYMAALAGGSCLGGLLVSFRPLSRRRSVLQAGVLFGLLGVLSLPSALAASASAYLAMLPINSLALVPLNGLGSAELERRLGQGSRGEAFGWFNAAMRLGGGTGATLNGLLLSILRPADVPLLASGVFLCMPVVLAGAALARRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT20</accession>
    <name>A0A7K0JT20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000474">
        <property type="protein sequence ID" value="MST33077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="12294" checksum="8402A55231DF0AD2" modified="2021-04-07" version="1">MSAARQPAPCARPDCPNPVIRPARRGRPPIYCSPARRAQAQRRPPPEPILVEVDHGSLTAHRRPAGRVWLVRLRRGPHAVTVASGLGRTTADHRAAQIITIIANRSTPAGAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE0</accession>
    <name>A0A7K0JTE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000525">
        <property type="protein sequence ID" value="MST33216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25507" checksum="84B3C97EEADD636B" modified="2021-04-07" version="1">MPERRPAGPTPSAVIEDYLRGIHAIEEVGGSPAATTDLARRLGVSVSAVSGMVRRLSAAGLVDHRRYGRLALTDEGRRAALGVVRRHRLIETFLVEVLGYGWDEVQDEAEVLEHAVSDRLLARMAELLGHPGRDPHGDPIPGPDGTVVAEATQPLSALPAGTACRLVRVLDAPGDLLRWLSDEGVGLGESLVVGSWDPGGTLPVRLREPGRILRLGPSAAARLQVTVADDAGPVPGPGRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF5</accession>
    <name>A0A7K0JTF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000416">
        <property type="protein sequence ID" value="MST32874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="6013" checksum="7E98689FFB57DA92" modified="2021-04-07" version="1" fragment="single">MTRVGLETGERWVFASALDWPGWARRGKGAEAAVEALDAYADRYAAVAGAGFAPGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH5</accession>
    <name>A0A7K0JTH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3068 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000402">
        <property type="protein sequence ID" value="MST32829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="431" mass="45041" checksum="9255CFFA746124E4" modified="2021-04-07" version="1">MPPGPGGADLRPWPLSGAVSRLGAHSDRGFPSMRRTRAMIGIGIALVVIAAGVRFIAAPAFIRFPLGIDRHYTYTGDVTTIANPLTLAPVTLPSGAPLTIDRQIKVVSGSYSTAVVQETDTLKFAGRSSTETYQYALDRRSMKMQNGSDTYAFGNPANAMHVNSSYRVNLPLGASSSSTYQGFTPQSDSLSPLRPQGAAHHDPVSDSTVITYAFSTDHPVAPYYLAHLHSMGFPASLSPAAAAADLRAHGVDVGGLLGSLRARLTPGQLATLTAILAKPVPLNYTYFAKGTVGVDPTTGAVVNSTASREGVAVSPNLAAYASLAPILSRLSGLPAVQSFGKALQGFASAPAIPVLTFNYAQTSASARSAASDASSQATMISLLDWWLPIGLAALGVILIIVGWFTRPRKRPQVAAAKPSPTPQPEEPKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL8</accession>
    <name>A0A7K0JTL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000542">
        <property type="protein sequence ID" value="MST33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="131" mass="14037" checksum="AB377441FB32F071" modified="2021-04-07" version="1">MGLRLVVEVEGEDVRSGEGLSGRAWIINTGSDPVDMRTLRTVFGGVALPGGDRLLGQFRGWQTTVGPSRVRIAAGAAHELHLLVGTDAGWAEPLRRGTYQVLAHAEVLVDGPPQRHVELRAVGPQLELIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN5</accession>
    <name>A0A7K0JTN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000421">
        <property type="protein sequence ID" value="MST32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="13314" checksum="57ACEF2DC03FB057" modified="2021-04-07" version="1" fragment="single">MKLTVLGMGQMGRALATRLLDTDHSVTVWNRSPGKAGDVVARGATEARSVEEAVAGAEAVLTMVTDDDAVRSVLLPGGSPRPLDAVLDCSTVSPTTTRELAAAYGPRFASCPVLGGPAATAGGEAALVVAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ7</accession>
    <name>A0A7K0JTQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000563">
        <property type="protein sequence ID" value="MST33332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="61"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="35991" checksum="0C86B656BF992AE7" modified="2021-04-07" version="1">MQPEGLPIELRSAPFRRILRNGTVAPSTRGGSLPPIGATPGSPSAGAAGTYPLAGRTVARVGFGAMQLPGPGVWGPPADRDRALAVLRRAVELGINHIDTADFYGRSVANHLIREALHPYPDDLVIVSKVGATRDDEGAWVPAQRPADLRAGVEANLRSLALERVDIVNLRVMGSDDHHELPPDQQVDLDSQLAEMVALREEGKIGAIGVSTVTLEQLRQALPAGIACVQNPYSVLDRSGEPLLELCARRGVAWVPYFPLGSAFAGMPKVAEHPTVLDAAARLEVSPAQVGLAWLLAHDERILLIPGTSSLEHLADNVATAEVRLDADTMAALDALGAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU60</accession>
    <name>A0A7K0JU60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GCV_T domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000612">
        <property type="protein sequence ID" value="MST33485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCV_T" evidence="1">
        <location>
            <begin position="58"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="23265" checksum="F06FF39E65687EFD" modified="2021-04-07" version="1">MPTTTPRGCASVADLAVPVARSPIRPVGPATVVDGWEHATGAVTRAGLRLCDLSHLAKVTVRAPMDGQVAAALVVPHGRAVRDAGARRLVIGSGPGEWLVLAPQGEGPALLADIEARVAGTGEFVSVVELTHGRALMRLTGTDAVTGVLAKLCAVNLSDKATPDGTALRTSVAAVVTDIVRDDVDSERSYLLHCERSSGQYLFDALLDAGGDHGIEAHGATDKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU91</accession>
    <name>A0A7K0JU91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000479">
        <property type="protein sequence ID" value="MST33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017003">
        <property type="term" value="P:protein-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004329">
        <property type="entry name" value="CcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036127">
        <property type="entry name" value="CcmE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03100">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82093">
        <property type="entry name" value="SSF82093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604329-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="134" mass="14286" checksum="2C81FE48EA5BDA5C" modified="2021-04-07" version="1">QAVAGCVILAAVGFVAFQGLTNAEQYFLTTKQAVAQRAQLGTKPFRIEGSVEHDVRQSGNDIRFDIYNQGVTVAVDSSGSPPQLFRPGIPVVLVGHWQGNVFASDQIMVKHGARYTAAHPGRLKSQLPAAGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD1</accession>
    <name>A0A7K0JUD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FA_desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_12570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="276" mass="30412" checksum="EBD20064F4694D0F" modified="2021-04-07" version="1">MRTPGAARTTRLPLGQSGTVRRVPGPLLAVIVGLATCQVGLYLTTVVLHRAMSHKALTLTRRPMFAARALIWLTTGIKPREWVAVHRKHHAFTDVEGDPHSPAVSGFFMVQLANVVLYKRAANDPETVRRYAKDLAPDRWDLALFDKGWLGLGIGVGIFFLIFWGNWELVVIASAVHVGSYLLASSAINAIGHRFGKRPYAGRATNNQWLAWLVAGEGLHSNHHAAPTSARLAFKAREIDPGWWVIVALRRLGWAQVRHQEVRLKARATAPAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK4</accession>
    <name>A0A7K0JUK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_13000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000667">
        <property type="protein sequence ID" value="MST33632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10831" checksum="D84AD5242349EFED" modified="2021-04-07" version="1" fragment="single">MPRAMLKTFAEAVMSAQASLQCGAGYGERSEERENSRNGYRHRRWDTRVGTIDLAVPKLRSGVYSPEFLLTPRRRAEQALVAVICQAYVEGVSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ9</accession>
    <name>A0A7K0JUQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000689">
        <property type="protein sequence ID" value="MST33682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="69" mass="7427" checksum="60654211AB595683" modified="2021-04-07" version="1">MTCHHPNPDPLDPDGYYLQRVVITLDIPGGPGTDATAAAALLDVLDHFRHDAIQAHWVTLEISGPTTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS5</accession>
    <name>A0A7K0JUS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycothiol synthase</fullName>
            <ecNumber evidence="3">2.3.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshD</name>
        <name evidence="3" type="ORF">GHK86_13380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000695">
        <property type="protein sequence ID" value="MST33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="19582" checksum="C86411F8F1E7B833" modified="2021-04-07" version="1">GRALYQMRRRLPVEPELVLQPLPPTRAFVPGRDEEEWLEVNNRAFEWHPEQGGWDLATLKEREAAPWFDPEGFRIYEEAGRIAGFCWTKVHVDHDPPLGEIYVIAVDPQATRRGLGRGLTLAGLDHLARRGLQTGMLYVDATNTRAVKLYVDLGFVVNHIDQAYVGDIAPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS7</accession>
    <name>A0A7K0JUS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="9976" checksum="C47080325970FD6A" modified="2021-04-07" version="1" fragment="single">MSEPQLERSVLEAKEREELFAIANALGTRPTSRARKSELISQILQATGVEVAVPEAQAEARPRRTRARKATEAAPGSEQLPLGEGAGEQERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU0</accession>
    <name>A0A7K0JUU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3263 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000702">
        <property type="protein sequence ID" value="MST33727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="13105" checksum="3ECA89D60CE20DBC" modified="2021-04-07" version="1">MPATGEDASSGTVRRCLIRRGQGGRLGRMGLSERDRAILDFERSWWMEPGSKEGAIRARLGLSSTRYYQLLAVLADSDEAERYDPLVVRRLRRVRRERRRARFEGRSAGGRPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU2</accession>
    <name>A0A7K0JUU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000698">
        <property type="protein sequence ID" value="MST33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="17834" checksum="6F7E075D5BCB8A3F" modified="2021-04-07" version="1" fragment="single">MPIRTGGWHGCGSRGAVEAAAVAIGPVDLLVNNAAIWRFAPLEDVDPAEFERVLQVNLLGPFNTMQAFGRQMLARGRGAVVNVVSIAAAHPSPFVGAYPSSKAALVALTRQAAFEWGPRGVRVNAVGPGMIRTDAAGMYHDPEVVAGRAGAVPLRRLGTGEDIAEAVAWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV12</accession>
    <name>A0A7K0JV12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000733">
        <property type="protein sequence ID" value="MST33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="323" mass="36008" checksum="151489380B37C598" modified="2021-04-07" version="1">MEYVNLGTTGLQVSRICLGCMSYGDPKRGNHEWSLPEDDARPFFRRAVEAGINFFDTANVYSDGSSEEITGRALAEYADRDEIVLATKVHGRMRPGPNGAGLSRKAIMAEIDASLRRLDVEYVDLYQIHRWDDRTPVEETMEALHDVVRAGKARYIGASSMWAWQFAKAQHVAEANGWTRFVTMQDHYNLLYREEEREMIPLCRDQGVGLIPWSPLARGRLARPWDTTSARSETDEFGKTLYHESDRAIVDAVGEVAAARGVPMAQVALAWMLGKPGVSAPIVGATKMTHLEDAVAAVDLRLDPAEVERLEAPYQAHPIAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC3</accession>
    <name>A0A7K0JVC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid pRiA4b ORF-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000765">
        <property type="protein sequence ID" value="MST33898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="PTHR41878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="21288" checksum="E8A9B34E01BE3544" modified="2021-04-07" version="1">MSTTDGAGLQLTVHELQVTLLDVSPPVWRRLRVPSAVTLSALHSILQVAFGWQDAHLHEWRVGGRTYGLADEESWGEDLADESSAVLGELAPADSVLHYDYDFGDGWEHLVEVLAVEPYDPTRPPVLLLAGARAAPPEDSGGPLGYEHLLDALADEDDPEHDEMMEWVGDAFDPDELDVQAVNRRLEGMWRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC6</accession>
    <name>A0A7K0JVC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000763">
        <property type="protein sequence ID" value="MST33893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7085" checksum="979F56DB60CC29C1" modified="2021-04-07" version="1">MWLDPAVHDPRRLLPLLEPSPDDGWEAWPVGSAVNAVANDGPALLERVEPPARVEPPDALFPLPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH1</accession>
    <name>A0A7K0JVH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000619">
        <property type="protein sequence ID" value="MST33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="215" mass="21142" checksum="824B423F510AC51B" modified="2021-04-07" version="1">TAGRGMRAAVEGFRFIHQQRPVLGAIVADMSAAFLAMPIALFPAINAARFGGDPTTLGLMTTAVATGGILGASLSGPASRLRRRGLGILAAGTVWGLGIVAFGFADSFWLAALSLLVAGAGDSTAVVLRTAVVQELTPDELRGRVSAAEFAAGAGVAQLGNLRAGALASLTSPGVAAVSGGLSAVAGAVLIGTLVPALVTLDRSPTAAAANRPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN4</accession>
    <name>A0A7K0JVN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">secY</name>
        <name evidence="3" type="ORF">GHK86_14925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000809">
        <property type="protein sequence ID" value="MST34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="438" mass="47558" checksum="4A2ED9907C0592AA" modified="2021-04-07" version="1">MRSSLSNLSNMFRVPDLRNKVLFTLLMIAVYLLGANIPCPGISYAAIHEAATSGTHGGVFSLLNLFSGGALARFAVFGLGIMPYITASIIIQLLMVVIPKFEKWRDEGPTGQKKLTQVTRYTTIALAVLQSTTLVYAFHSGSPVLLGTSSSIDYIPHFSIPLVLLIILTMTAGTVVVMWLGELITQRGVGQGMSVLIFVNVVATMPAGGKTIEAQAGWAALAAIIVVSIALLVAIVFIEQGQRRIPVTFAKRVVGRRMYGGQSTYIPMKVNTGGVVPIIFASSVLYFPFLLSNLLPSKGWGLTVQTWINSHLAQPDDATYIVIYGVLILGFAYFYATLMFNPQQQADIIRKQGGYIPGIRPGPPTERHLQRILNRITLPGALWLAVIALLPALALAFFHIQNYPFAGTTLLIAVGVALETMKQVDSQLMLRNYEGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ9</accession>
    <name>A0A7K0JVQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">GHK86_15085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="WJHE01000821">
        <property type="protein sequence ID" value="MST34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="43"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="18343" checksum="E85359F65D7E9099" modified="2021-04-07" version="1">MALETDAVSALIRDVVDFPQTGVVFKDITPLLADERAFGACVEALADSFDGAAVDKVVGIEARGFIVAAPVALRMGAGFVPVRKAGKLPWRVERETYALEYGTDVLEIHADAIAPGERVLVIDDVLATGGTASAVTRLAGRLGSEVVGFGCIIELGFLGGRSRLDGVPAVSLVSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS5</accession>
    <name>A0A7K0JVS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000829">
        <property type="protein sequence ID" value="MST34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="131" mass="13709" checksum="217C8782296315AB" modified="2021-04-07" version="1">MSTLWTPDGERPIRRGGEQPAAAPAPEPAAPSDAELEAELAEVRDQLARTPAEVVVANHAYGLWQLAALHLSLEAPQLDQARTAIDAFAALVEGMQGRLGEAEGQLVGALEQLRLAYVEIARAGQAPPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW1</accession>
    <name>A0A7K0JVW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2344 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000845">
        <property type="protein sequence ID" value="MST34087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="15509" checksum="144E1297DDA835DF" modified="2021-04-07" version="1" fragment="single">MARVRIRFTKLGKVRWTSHRDVARMWERALRRVQAPLAYSQGFSPRPPISFGLALPTGHESLAEYLDVELADGEAGAAVVGDLPALTGRLSAALPEGVDAAAAAVLLPGASSLQEEVTSCTWEWTAVDAGGGTLDPAGLAGRCGELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW3</accession>
    <name>A0A7K0JVW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argH</name>
        <name evidence="7" type="ORF">GHK86_15045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000819">
        <property type="protein sequence ID" value="MST34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="6">
        <location>
            <begin position="365"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="433" mass="46382" checksum="599ACDE5C57ECE35" modified="2021-04-07" version="1" fragment="single">MTLWHGRFGEGPSEELLAYTVSLPFDRRLAADDLAGSRAHVRGLVRAGLLSGDDGAVLLAALDRVGVELAEGTFAFRPGDEDVHTAVERRVTEIAGDVGARLHTGRSRNDQVATDLRLYAKRELGDVAGLVLRLEETLLTRAEAAGEAYLPGYTHLQRAQPVLLAHHVLAHGWALARDVDRLLDTRRRLDVSPLGAGALAGSSLPLDPDATAEDLGFAQRFANSLDAVSDRDFVAEALFDLALLGVHLSRMGEELVLWSSEEWGFATLADAYATGSSMLPQKKNPDIAELARGKAGRLIGDLTGLLATLKGLPLAYNRDLQEDKEPLFDAVDQVRGGLVAMTGLWATVELDLERMRRAADTPAAAAVDLAEWLVERGTPFRQAHALVGALVRDSIERRVPLAELVEAHPALGEAAVELLAPGAAVARRTTPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX4</accession>
    <name>A0A7K0JVX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_15095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000822">
        <property type="protein sequence ID" value="MST34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="138"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="251"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="414" mass="45645" checksum="AB6654D4E2005955" modified="2021-04-07" version="1">MYDLAMSAGARPLLERVRRFVADEVEPMQEKFFALGEGRADRWSFAPGQLELLDGVKARAKAEGLWNFFLPDATTGEGLSNLDYAYIAFELGKQPLASECLNCSAPDTGNMEVLERVGTPEQKRRWLEPLLAGEIRSAYAMTEPDLASSDARNIACSAVLDGDEWVINGEKYYISGAGDPRCKVMIVMVRTNPDAAAHLQQSQILVPMDAPGVEVLGPMLVFGRDDAPHGHMHLRFTDVRVPRDNVLLGEGRGFEISQLRLGPGRIHHCMRSIGAAEKALQLMVERGLAREAFGKPIIALGKNTEVVSRARIEIEAMRLMVLRAAKAMDLMGNADARVWVSAVKAMVPERVCQIIDQAIQVHGATGISQWTPLAEMYTSQRTLRFADGPDEVHHMVVGRAEIARWQHAAPPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW41</accession>
    <name>A0A7K0JW41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="5">DHBP synthase</shortName>
            <ecNumber evidence="5">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ribB</name>
        <name evidence="6" type="ORF">GHK86_15660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000873">
        <property type="protein sequence ID" value="MST34153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="17314" checksum="2C7BA3852116CD8D" modified="2021-04-07" version="1" fragment="single">MPAASVEAAIEAIRRGEIVVVVDDEDRENEGDLIVAASHATPETMAFIVRHTSGLICAAVTAEQADTLDLPLMVARNTEVQRTAFTVTVDYRHGTTTGISAADRSATARALVDPEVRASDFNRPGHLHVLRAREGGVLVRAGHTEAAVDLARLAGLPPAGVLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW90</accession>
    <name>A0A7K0JW90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000898">
        <property type="protein sequence ID" value="MST34211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="35245" checksum="21CE5D26AB35ED47" modified="2021-04-07" version="1">MRVAVLGAGRMGQRRAHLLASDPRVDEVVVGNRTRARAEEVARAVGGRAAGLEEALDTGPEAVVVSLATANHAEYLLRAIDLGVPILTEKPLAADLEGTWAAVAAARDAGVAVQVAFMRRFDPAYVEAGRLVASGALGTLYHVHMTSHDRDVTPLEYLPGSGGIFRDLHVHDFDAARFLTGREIAEVDARASVRAHARFAEHDDFDTATVLATMDDGLTVTVSGARHDPLGYDFRVELFGSADSVATGLGPRTPLRSLEPGSPGAPPHAYEGFLERFSAAFAAETAAFVDLVAGRGPNPCPPEEAARAMAAAVACERSVAERRPVALSEVEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW98</accession>
    <name>A0A7K0JW98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000901">
        <property type="protein sequence ID" value="MST34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="331" mass="35900" checksum="0EFB16B5476D883E" modified="2021-04-07" version="1">MPEGHTIHRTARDHARTLAGGPVRVTSPQGRFAAGAATLDGAFLRGIDAWGKHLFYRFEPDLTLHVHLGLYGKFWPWTPPPAATHRQVRLRLEGKAHGYDLTGPSTLPRSIRARDAVGRLLSTAAAPDPRARRPWPARDLAVAATFCVTGVREAEAVGLDVGSLQGEPGARRLEVVGKGRKVRPVPIDPSLDTVLGRYLDERRAMALDGDDLDHPSTPLFVDVRGRRLTVDQIRYLIERLYVRAGIRAQVPAGALVHALRHTFATSALEAGADVVELQELLGHASLETTRRYLSATAQGLRHVIQGHPSQAAVRAALADRPADAAGDVADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG1</accession>
    <name>A0A7K0JWG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000929">
        <property type="protein sequence ID" value="MST34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029814431" evidence="1">
        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="28857" checksum="B7907399E0914997" modified="2021-04-07" version="1">MTAVVMVAAVTVATARSTAPPIGVAAGAPPAAVATRRLLASLVRPDQTAEQSARQTATHPAVAPAPVGALFASGSGNHYCSGSVVQSAHGDVVMTAAHCISGNGTNDVFVPGYDDGRAPYGRWRVVAAYAAPSWRSAQDPQDDVAFLVVAPQRIGGRMLQIQQVTGGYLLSTAPTTDARVTVVAYAAGNDDAPLRCAPWVYWHQGFPAFACAGYPGGTSGGPWLTVAPGRTDTVDGIIAGLHQGGCRTGVSYSPAFGASVRAVYQAAVDRAPAETLPAPGSDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS4</accession>
    <name>A0A7K0JWS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000984">
        <property type="protein sequence ID" value="MST34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="14855" checksum="3A7AB377E1314BB9" modified="2021-04-07" version="1" fragment="single">MTAWICATCGNQHADTPEPPAVCAVCADERQWVPPTGQRWTSLAALAAAGHHSDVREVEPGLLGVGVDPPVAIGQRGLVVRTDEGNLLWDPPGFVDDAAVGAVRGAGGLVAVAASHPHFYGTIVEWSRAFGADILLPAADEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX19</accession>
    <name>A0A7K0JX19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_17420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001037">
        <property type="protein sequence ID" value="MST34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="11238" checksum="6C514BDA6B08A10B" modified="2021-04-07" version="1" fragment="single">GFMAVHLWAKFWMAAWRGRRTLTWMTGVVCFLVAVIEAFTGYLSQTNFDSQWIAFESKDAFNGAGIGAVLDPMNFGQALMLHIALLPLALTAFVVFHVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX67</accession>
    <name>A0A7K0JX67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001061">
        <property type="protein sequence ID" value="MST34540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="27870" checksum="EA67E73A540F58FF" modified="2021-04-07" version="1">AETLLAAHRTDLGLTYPPNIPAYRAQGLDYEAVAGLAQVNTINIAVLKSSPYHAVAQLSGKLYGGFGVSSDKPIMLDVFRKAGVAHPVYREVNLGVDAYQALAAHRVAYSITYGGIDDITAELNGVALRQFPIKRYLGAAFSFPDDAFVALDHEVNAHHALFAHALRALARGYEYAAAHPAAAEAILLKDNPAALAGAKRVIDATGNATAPTFVGKQGTWGRLDDADFAGLTRILVKGGLIPAGKAPAAGQDFTDSLLPTTPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG0</accession>
    <name>A0A7K0JXG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001118">
        <property type="protein sequence ID" value="MST34637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="15444" checksum="BDE15DDF13F9903C" modified="2021-04-07" version="1">MASETGLTGVLGGFPVLGVERIVRRTLISAVVAGLVAAVVAIVVGYPLIAPGLLLGLALAVLNHRVFQSSAMRYIDPEGSVRRKPFTGSVLARLGLCTAVAIVLLIWVRAMGFGVIAGLAIFQGAMLVNAVVALIHYQRVEIGGGMPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI5</accession>
    <name>A0A7K0JXI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000908">
        <property type="protein sequence ID" value="MST34239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029878138" evidence="2">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="17939" checksum="0AAD0EF65EC0F831" modified="2021-04-07" version="1">MREEGRDSRRSGAGGAAAVLTLAALLAGCGAGSVKAAAPTTTTTTTTTTTTTVPAGTGSSSAAPAAIRKDWVAFFDAKTPTAQRVALLQRGTAFRSAIAADAGSPLAKAASARVEAVTVDSTTKATVTYDIVVAGQPALTNQKGTALLIGGTWKVGDASFCSLLGLQGKPPAACGPAASTSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM0</accession>
    <name>A0A7K0JXM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001160">
        <property type="protein sequence ID" value="MST34701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="260" mass="27147" checksum="416A41FF2ED94836" modified="2021-04-07" version="1">NDLGGSVHGDGADRGPAEAVAAQIRDLGGEAVAEGSSVATPEGGQAIVDAALEAFGRVDIVVNNAGILRDKAFHNLTPDLLDPVIDVHLRGAFHVTRPAWIAMREQGYGRVVNTSSNSGILGNFGQSNYGAAKMGLVGFTRVLAAEGAKYNIKVNAIAPLARTRMTEELLGAAAEKLEPALVSPVVAYLAHEDVPVTGEVYSVGGGRVARFFIGMTHGYTNPSLTVEDVRDHFGEIRDESGYTVPAGPADEFKALVEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP4</accession>
    <name>A0A7K0JXP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001178">
        <property type="protein sequence ID" value="MST34728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="21088" checksum="B248B22B3A914465" modified="2021-04-07" version="1">MQLRSDGAITEAPADGDDRELPDDRLRRVLDAIPVPVLVLDGRGRTVAANTALRDLLGLTGRDGTTDGTVAVVEGRPGRFLARTPGWQRVWRIIEEGPTERPRLTAVEDARGDRRHVEVTVAAGPDDGERTVTLHDVTPVRTLRQQVSTQVKVLSSARGQLRAARDEMRQAEAQFAELVAELEAATEASPPHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP8</accession>
    <name>A0A7K0JXP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CheB-type methylesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001180">
        <property type="protein sequence ID" value="MST34731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="20362" checksum="F60EB066055F8D5B" modified="2021-04-07" version="1">MSSRPGDGRRCHDGLMGSVVVIGGSAGAHGALQTVCRGLPPDFPAPILVVLHVPPHLPSRLASILTRAGPLPATEARDGQELLAGRIHVAPPDHHLLVGADGRTSLGREAPERGFRPSIDVLFRSAATAFGAASVGVILSGALTDGVAGAEAIRGEGGAVIAQDPEEARFGRLPRAAVDAGAADVVVPTAAIAATLCRLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU2</accession>
    <name>A0A7K0JXU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001210">
        <property type="protein sequence ID" value="MST34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="60"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="25648" checksum="71E8ECB25EBF9517" modified="2021-04-07" version="1" fragment="single">MATFTAALLRVVRSVPAFQSRGKPPRYSRRGPAPARGGAACGLRISDGHRPLLWPVRTLVVIGCGPWGLCVLERLLSRARAQRASVAIHVVEAGRPGTGVYQTDQPDYLVLNNPCGQLSLYARPEADRDPPYGLGLFEWARRRGYGWVGDECRVGGRGRPVEPTDFLPRRLMGEYLQWFYETLVADAPAGVAVIHHPTPAVDVVAIGDRELVVLGDGSSVAADRVVLTSGHTPNLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY3</accession>
    <name>A0A7K0JXY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="10" type="ORF">GHK86_16810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000973">
        <property type="protein sequence ID" value="MST34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029611298" description="NADH-quinone oxidoreductase subunit A" evidence="9">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="20613" checksum="55B4314C252F3FB1" modified="2021-04-07" version="1">MVQYLPIVLMLALAALFAAGSFVASAVLGPKRPTAAKEGPYESGIVPRRAPAARFPVRFYLVAMIFIIFDIEVVFLYPWAVMYRQLAGFGLAEMAVFVGIVFVSFAYLVSNGALDWGPVQKLRNRPQADLTRTTSNAVRRVPRPLEVAMDGPGLLPLDGEGAGGDGAGADGDGGGSAGGSDADWGPPVGARTGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ9</accession>
    <name>A0A7K0JXZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ftsW</name>
        <name evidence="10" type="ORF">GHK86_19090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001234">
        <property type="protein sequence ID" value="MST34820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="358" mass="37748" checksum="89754F5B1B46726D" modified="2021-04-07" version="1">DKIAEEKRALLRAYGAEVVVCPSSVTSLQQYGSPWHFFERQLLWLVIGTGAFFVALRVDRRRWRRFARAAMVVALGLLFVVLIPHVGVGAAGATRWLGTSSFQIQPSELAKLALVFFAADTLDRRAERGERGDWRYQMGPVLAIVGLLAVLVMAQPDMGSTAVLVVIGLAMVGTAGIPGKPLAAIFGLVGVLGMLMAVVAPYRWRRLTAFVHPFKNASGSGFQSVQGLFALGAGRLTGDGIGTSLASWGYLPNAQTDFIFAIIGEETGLVGTLLLTGLFLAFAVVGVRIACGARDRFSGLVAAGIVAWLIGQAVINIGAVVGLLPVTGVPLPFVSYGGSSLVLTLFGAGVLGNIARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE6</accession>
    <name>A0A7K0JYE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001325">
        <property type="protein sequence ID" value="MST34957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8778" checksum="C182FD4898132232" modified="2021-04-07" version="1" fragment="single">MASESHRAIEAILMVADRPIEPGLLAQVLEVSPARVDELCRELQASYSAEDRGFCLVRVAGGYRFQSHPDLAAYVERFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG2</accession>
    <name>A0A7K0JYG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001345">
        <property type="protein sequence ID" value="MST34990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10235" checksum="216557015AE398AB" modified="2021-04-07" version="1" fragment="single">GEDALEVAPVDGGERRRLAAGQLSQVVDLAASPDGAWVATAADDGSVRVTEVTSGTVRQLDRSEYDNVNGLAWSPDSRWLAWSHAGAADADDTGGLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU4</accession>
    <name>A0A7K0JYU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001171">
        <property type="protein sequence ID" value="MST34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="15604" checksum="D91A91D2BB751CE3" modified="2021-04-07" version="1" fragment="single">TYDPVLVRLSGVDAAKLPPLRPTASVIGPVLPDVAADLGLPPATSVVAGTPDLHSAAVGAGAVGDYEAHLAISTTSWISCPVPRKKTDPFHQLATVPGVTPDRYLLVDNQDNAGRCLEWLRDRVVTASDGYADLVELAAAAPAGSGGVLFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ14</accession>
    <name>A0A7K0JZ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001503">
        <property type="protein sequence ID" value="MST35190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="11452" checksum="89348C6DE1E7AD58" modified="2021-04-07" version="1" fragment="single">GRPPTGGRLVRPGPIGLGAPGGTAFVAQHPESQVLGVRVADDLVWGLPRDWPVDVDGLLATVGLAGLATRETSGLSGGQLQRLALGAALARRPSLLIGDEVTAMVDAGGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ25</accession>
    <name>A0A7K0JZ25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001224">
        <property type="protein sequence ID" value="MST34804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="29417" checksum="6A8FABA45EB7F689" modified="2021-04-07" version="1">MSAPSQQQEPPGRRSAMAPRPDCGEDSYQGHGRLLGKAAIVTGADSGIGRAVAIAFAREGADVVISYLEEDDDARDTAGWVEKAGRRALLVKGDVSDARHCRKVVAEAVDAFGRVDVLVNNAAYQMTHDAIEEVSDEEWDHTFRTNVYAMFHLVKAALPHLPPGSSIIGSSSVNSDMPSPTLAPYAATKAAIANFTASLAQLLGGRGIRVNSVAPGPIWTPLIPSTMPEEKVASFGQDTPLGRAGQPRELAPIYVLLASDEGSYMSGARVAVTGGRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ41</accession>
    <name>A0A7K0JZ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001528">
        <property type="protein sequence ID" value="MST35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Succ_CoA_lig" evidence="1">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="18865" checksum="8E3E1A631F623603" modified="2021-04-07" version="1" fragment="single">MDAAAELHLASNDLPAGPIGLISQSGNLALEVGMRAEAARLGFARFASIGNQADLQVADLVEDFALAPGIEAIALYCEDFRDGRRFLEVARAATDAGTPVVMITVGASEAAARAARSHTGAMVSGQRSIEAACRAAGIEQVQTPKELVDLLQGLLLPAAPRGRRVAILADGGGHGAVAAEVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ49</accession>
    <name>A0A7K0JZ49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Site-2 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GHK86_20820</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001481">
        <property type="protein sequence ID" value="MST35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="27393" checksum="730C8322265B161B" modified="2021-04-07" version="1">MTPPQAPRPARRFRIDGQILVVVGLVLLAAYGLRHSIGLSFVLVLIVIIPSIILHEVSHGVVALACGDDTAKRAHRLTLNPLRHIDPVGTLILPAVLALSGLGAFGYAKPVPIDPRRMRHPRNDAILVSLAGPATNLALAGLSIVALRAITPADQLHQLPQLLAYDPGALGIPTELLYLLGLLNVVLAVFNVLPIPPLDGSVLLERLLPASALQTWWRIRRYSMLVLLAIVLLVPGVLTHIFRPAENAWAHVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ67</accession>
    <name>A0A7K0JZ67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4389 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001549">
        <property type="protein sequence ID" value="MST35246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029881127" evidence="1">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="11773" checksum="53AAD919C7E78B9B" modified="2021-04-07" version="1" fragment="single">MRPWKIVLLVTGALLGLVGLGLAAASGTLLWANATQRDSAGYYVTPTTRLHTGTYALTSQADFGSASGDWVPAHPVGTVRIRATGVGPPVFVGVGPRSQVDHWLAGVAHARVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD5</accession>
    <name>A0A7K0JZD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001637">
        <property type="protein sequence ID" value="MST35331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="13441" checksum="72CF9724E3C4D697" modified="2021-04-07" version="1">PDLDRWYLRLRGEEKAVTTIWLTLRERTLHFETYFMPAPEERREECFDYLLRASAGLFAWRFAVGAEDAVYLVGQLPVGAIDEEELDRIVGSGYAYTERWFRPAMRIGYGSRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF5</accession>
    <name>A0A7K0JZF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001569">
        <property type="protein sequence ID" value="MST35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="6171" checksum="FEE5AB9113FC2E4D" modified="2021-04-07" version="1">AWVVRRPGHRVGAEELKQLVRGRLAGYKVPRRIHFVARLPRTTTGKVLRRELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K007</accession>
    <name>A0A7K0K007_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coproporphyrin ferrochelatase</fullName>
            <ecNumber evidence="2">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_20680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001458">
        <property type="protein sequence ID" value="MST35134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="322" mass="34479" checksum="AFA2F441BD1C5104" modified="2021-04-07" version="1" fragment="single">MNPPDALLVLSFGGPEGPDEVLPFLENVLRGRNVPEERMLAVAEHYHHFGGVSPINAHNRALVAAVRDDLAVAGIDLPVYWGNRNWHPLLADTVAAMRADGVRRAAVFVTSAFGSWSGCRQYREDLGRAAAPGDPHLDKLRLYYDHPGFVEAVADGLAATLADAGPAQVWFSAHSIPLSMAATAPYEGQLQTAARLVAERCGLDDWQLVYQSRSGAPGQPWLGPDVTGRLRDSRPGGTVVVCPIGFVSDHMEVVYDLDTEAAAVAAERGVRFLRSPTAGTHPAFVAMVRELLVERLDPAAPRRALGPDGPWPDECPAGCCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMH7</accession>
    <name>A0A7K0JMH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000006">
        <property type="protein sequence ID" value="MST31148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029852957" evidence="1">
        <location>
            <begin position="34"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="264"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="359" mass="35999" checksum="5AAA103BF23822A7" modified="2021-04-07" version="1">MSEPGPPRRRRRMILPAVAAAVTVAVSVAVAFAAGAPPSRHPVACGGPRSPGALERAIDPALVDVDVDLAGGHGFAAGTGMVLTATGEVLTNNHVIDGASAITAVDVGNHRRYRVRVVGYDVGADAALLQLEGARHLRWVSFGDSGALTVGTPVAVIGNAGGAGGTPSCSTGRVTGLHRTVTASEESSGLSERLTDLIRTDAPVLFGESGGPLVVAGAAVVGMVTATTGEGAGAGGGYAIPAARARAVAERIEHGRASPQVHIGPTASLGVQVEALPSTGPSRQVVVVLAVPEAGGAHAAGLRPGDVLLSLDGRAVTSPFGLQLLLQRHRPGTPARVTWRDGYGRTRTATLILVTGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMK2</accession>
    <name>A0A7K0JMK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="16344" checksum="E092DA204E561B00" modified="2021-04-07" version="1">MRADQTTERSTAGFSLIELLVVVLIIAILMAIAIPTFLSARTQASNRATEARLQNAVTDEQTFASQSADGAYGPAATLVNYNVDAALQFSSSWPAPGPQIFVDPGTDASGNHTVLLGTADQAGHAYWVYDDAGALTYAVTAGSKPTSLPLPDTSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JML0</accession>
    <name>A0A7K0JML0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000016">
        <property type="protein sequence ID" value="MST31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="3"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="321" mass="33303" checksum="933ACC2644F7B92A" modified="2021-04-07" version="1">MFVLDGDYGVDDAIALLSLAGEPGVRIVAVGSVHGNTDAARAARNALTVLDLVGLREVPVAVGAARPLAQPVELSAEVHGDDGLGGVAPPEAAVGRQPVGTPAAVQLVEAIRAHPGGCTVLATGPLTNLALAVLLDPGIVELVPRVVVMGGTLDAPGNVGTHTEANFAHDPEAADLVLRAGWPVTVVGLDVTMRTWLEEEDLARLAASDNPAARFVSEVLPHYVQFYLGRHGRPGCPMHDPTAARLALQPELARYVELPAAVELRSPTTRGMLLLDRRPFASHPPGAIPVRVAVEVDRDAVVGRLVDGLVRGDAGLQSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JML5</accession>
    <name>A0A7K0JML5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_00270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="292" mass="31055" checksum="3917C16845E5C244" modified="2021-04-07" version="1">MSTVPTTPPTPESDTREAVRRLVLAADYELIPLKGLDDKLGALPPATTVTVTSSVKLGLERTLQQSLRAAAAGYHVVPHLPARQVRDEAELRSFVGRIRDAGITDLYVIGGDAPDPLGPYQSAAQLLAALAGIDHGLQEIGVACYPEGHPSITDEALLAALLEKQPHATYMVSQLCFDGDAVLGWLRGIRQAGVTLPLHLGLAGPLSMLKLAELSVRIGVGASVKYLTKQHGLVGSLLRGSSYKPEDLLLGMGEDLTAPEMGIASLHLCTFNQVEATHDWQRRIAGGGLDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMP3</accession>
    <name>A0A7K0JMP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15658" checksum="8AE557DA67A243E3" modified="2021-04-07" version="1">MQQRAGIESGGELRLRLQLDELVSTMCKALNDPKRLMLLYSLRDGQRTVGELCQMLGAPQSNTSQHLAILRERGLVSTERRGSSVLYSLRYPELLDAVDLLRGIMSAEVDRQLQLRSLAPPEPVQRRSPPGPRGAGRLQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMS2</accession>
    <name>A0A7K0JMS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="541" mass="59029" checksum="E404DBC1D6CB2937" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMS3</accession>
    <name>A0A7K0JMS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="25952" checksum="E1B660A850E848B7" modified="2021-04-07" version="1">MLGDPVLADLVRWAANRRPLSYQLGAIAAALAVLGQRLAAGETDAEVLAGLVITAVDQAQRLAYSPVPDRAMLSDCDAIADAGLVGAGDRPSLVSMVVPHLLARAGCRLSTRSVLARRVEAAVDVCLGAWLHNARAGGGLPEFRLAVSCNQKRRVSALLGADRDLQRLVEGPRPGRSRPLHVTRRQGLAYWVALALRSAADGSPLPALPPDVAGHWRSELSRFGVTPTVASCVPAMSDAADQVLQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN14</accession>
    <name>A0A7K0JN14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmF</name>
        <name evidence="5" type="ORF">GHK86_00650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000024">
        <property type="protein sequence ID" value="MST31241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6479" checksum="C42FC8DB41BCBA26" modified="2021-04-07" version="1">MAVPKKKTSKAKTRSRRASNWTLSAPARSVCPQCHQAKVPHVVCPTCGWYKGRQALDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN67</accession>
    <name>A0A7K0JN67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000062">
        <property type="protein sequence ID" value="MST31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8912" checksum="F7FFCCAB08CB0521" modified="2021-04-07" version="1">MSADQEEVVARRPGRRPLLDIRGAGAYTGLGERYIRRLRADRSVPCIRIGGRLLFDPDDLDELIERHREPAIAAQGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNC8</accession>
    <name>A0A7K0JNC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000062">
        <property type="protein sequence ID" value="MST31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="65"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="164"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="384" mass="42233" checksum="1A8CE7DD666AA66E" modified="2021-04-07" version="1">MARRDYGSVRKLPSGRWQARYRNRGGRMVSAPETFTTKGDATAWLAQAQTDQARGQFIDPRAGRITLGTFADRFLTERVLAERTAETYRGLLDNHIRPTLGDIEMGQLAPGTVRAWHAQLARRHPSTAAKAYRLLRTICNTAVLDEVIARSPCRVEGAGTERAEERPIATLEEIAVIVEAMPARFKALVLLATWCQLRKGELCALRRRDIDPMRSTLTVAQNLQQLRDGRLVIKEPKSAAGRRTVVIPSQVLPVLVEHLATFTAADSDALVFTGEHGGPVRPHVLQKHWARARVAAGRPDLHMHDLRHTGNTWAAATGASTRELMARMGHSTPDAALRYQHATEDRDRVIAEALAGLTKPAPVVAIERAMGASPADADSNPPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI2</accession>
    <name>A0A7K0JNI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-type integrase/transposase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000090">
        <property type="protein sequence ID" value="MST31532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="34799" checksum="98EADBBD52EA5D44" modified="2021-04-07" version="1">ATTMRLLAECFELLGGTPKVLLTDRMGCLKGGVVANVMVPTPDFVRFATHYGFRPDFCEAADPESKGMVEACCGYVQTDFIVPAAPWADLAEANVAARVWCAEVNGRVHSTTMAVPDERLVEERKLLRPLPGLRPPLRAGERRRVDKMSTVRFGSARYSVPRHLVGTDVMVIAADGRVSVEDRAGETVAEHRLVAPGECSLVDDHYGGPRRAPARAVRARTGTETAFLALGPAAEAFLRAAAAAGTTKLGSELATITGLEAAWGRDALIAALERATTFRRFKAADIRAILDAGPAAPTVADEGGLLVTGLPQAPVRDLAAYRLEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR7</accession>
    <name>A0A7K0JNR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit M</fullName>
            <ecNumber evidence="7">1.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000105">
        <property type="protein sequence ID" value="MST31606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="376"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="777" mass="86598" checksum="BE2C1C24C2CE7DF3" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW6</accession>
    <name>A0A7K0JNW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000110">
        <property type="protein sequence ID" value="MST31656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="414"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="544" mass="57849" checksum="5E91C36535D974CC" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP90</accession>
    <name>A0A7K0JP90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029735356" evidence="3">
        <location>
            <begin position="22"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="706" mass="73419" checksum="415D5BC20A15DE4E" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE5</accession>
    <name>A0A7K0JPE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="72" mass="8217" checksum="F6CF0568A8010983" modified="2021-04-07" version="1">NRVGVEDLGDDDFYGTSYFVDPEGKFVGEVGSGESAEIMVRDLDLGLLEEVRQRWAFYRDRRPDAYGDLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH9</accession>
    <name>A0A7K0JPH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000151">
        <property type="protein sequence ID" value="MST31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="29392" checksum="20FD7D0F5DBA200A" modified="2021-04-07" version="1">MSEVRGFLFPRTATGRSSLLPPPPWHYSGDLLTVEWRTDPAAVAALLPEPLEPVHDDEDPGAVALIFADWQSCGDDLAELDDPVRLQYKEAFVVVRCRWDDRVWSRCVYIWVDKDFALARGHLQGYPKKLGSIHQTRPVTVGRAGPRLEPGGRFAATLAAYDRRLAQVRVTLTGRSESNGFVNGHPMVHHRWVPRIECDGKDALADLVTMRGRDVELGPAWAGTAEVELFDSPVEELTALAPREVLGGYWRSVGTTFAGGETLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ4</accession>
    <name>A0A7K0JPJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000165">
        <property type="protein sequence ID" value="MST31886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="270" mass="29863" checksum="1DC1512BD7596125" modified="2021-04-07" version="1">MYSQHILWMRTKQKTVDDAWADIEDRLIPPVMAAISTLGGLPPRLEMMRIGETDPHGKMDQVVAPWSSSQFAAYDSATLSDKGANELLQHWSLACGLGAIAASLFHEAVEQQDRTAPSRRGIGNTVLSYFLVVEYIANNVTSQDRNNRRDDDNYTKQADSVVNELRVKLDRTQSIRKKAAAVSYAKNALDRLDLRFLSLRIEHAGHVLDIDQSAIDTALALSKLRNTTLAHAGSSAHLPADGPTLDDAWRTAQAFLTGFLAFHADSRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT7</accession>
    <name>A0A7K0JPT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0502 protein GHK86_02385</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0502 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000100">
        <property type="protein sequence ID" value="MST31579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01584">
        <property type="entry name" value="UPF0502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007432">
        <property type="entry name" value="DUF480"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38768">
        <property type="entry name" value="PTHR38768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04337">
        <property type="entry name" value="DUF480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26710" checksum="389407A46044A7C2" modified="2021-04-07" version="1">MASSSLSWPLVGASLACRPAWRPTPSLCSNAVQPLSPEQLRVLGALVEKEATTPDQYPLTLNALILACNQASNRNPVTAYGPGEVATIVGDLRALGLARVVHSPSNRADKYRHVLDEAWGLTKAELAVLAVLVLRGPQTVNELRTRTERYPSLDDLGGVEGVLHRLKNRYDEPYVVRLERQPGQREERWAHLLAGEVLEVPSAPAAGAPRSGSTERVAALEGELAALRQEVARLRADVDELRAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ02</accession>
    <name>A0A7K0JQ02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000198">
        <property type="protein sequence ID" value="MST32025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046094">
        <property type="entry name" value="DUF6112"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19607">
        <property type="entry name" value="DUF6112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="9108" checksum="062146CB769F7B89" modified="2021-04-07" version="1">MTTVVAGVNVSPNASGLPGISELQNIVGALLTIGLIAALAGLALSAIVWSVGNHSTNPVLAGRGKTGVLVSFVAAALIGGAVALINFFAGAGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ23</accession>
    <name>A0A7K0JQ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14907" checksum="602745360FFE6F11" modified="2021-04-07" version="1">MRSARRPSQLTGAARPVREPARRPRLISPGPKPPGSGRDRPDGRHLAPAPSDLRTAPCPQEDPMTDTTTTSQIPRLLYTPREAAQALGISRSSLYVLLSQGAIDSVRIGGSRRITAAALSAFIDTLTSEISGIDRYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB8</accession>
    <name>A0A7K0JQB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000223">
        <property type="protein sequence ID" value="MST32148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="55" mass="5412" checksum="6EB139CBB2DE699A" modified="2021-04-07" version="1">MTADGPDEARVEPACGHGALRTGQPGDPAALAVPTGTVSPVAASATARRTADGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE3</accession>
    <name>A0A7K0JQE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000138">
        <property type="protein sequence ID" value="MST31794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="16592" checksum="6921467F5FDCD229" modified="2021-04-07" version="1">MPDGISKVSIVISHGSLDEVYPGLIMANGARAEGIAANLFFTFFGLDVIHRARHDHIKVASVGNPGLHLATVVGGLPGMSSVMTHYLTHKMEQLDIPSIPEFVEMIADTGCGLYACKASADLFGLEKNDFIPQVDDIITVGEFYEKAAGGQIIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG0</accession>
    <name>A0A7K0JQG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3 6">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_05280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 6"/>
    <dbReference type="EMBL" id="WJHE01000220">
        <property type="protein sequence ID" value="MST32137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="34205" checksum="22ED48185458BE52" modified="2021-04-07" version="1">MTTVTYREAMRAALREALARDDRVFLMGEDVGRYGGCYAVSLGLLEEFGPDRIRDTPLSESAFVGAGIGAALGGMRPIVEIMTVNFSLLALDQIINNAATLLHMSGGQFNVPLVIRMTTGAGRQLAAQHSHSLEGWYAHIPGLRILTPATPEDARGMLWPALADPDPVLIFENGALYNDRGELPADAGAVDITSAAVRRPGADVTIIAYGGTVRTALAAAEELAPEGVECEVIDLRVLRPLDTATLLASVGRTHRAVVVDEGWRSGSVSAEIAARLTESAFYDLDAPVARVCSAEVPIPYAKHLEEAALPSVAGVVAAVDHLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG4</accession>
    <name>A0A7K0JQG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)mycothiol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.306</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.306" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000235">
        <property type="protein sequence ID" value="MST32186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050607">
        <property type="term" value="F:mycothiol-dependent formaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="17"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="361" mass="37416" checksum="E2F67751A0110BE2" modified="2021-04-07" version="1">MAQQVRAVVAKAVKEPVAIETIVVPDPGPGEAVVAVQACGVCHTDLHYREGGINDDFPFLLGHEAAGVVEAVGDGVTDLAAGDYVVLAWRAPCGQCRSCRRGRPWYCFDSANAAQPMTLADGTPLSAALGIGAFAEKTLVAAGQCVKVDPRARPEAAGLIGCGIMAGFGAAVNTGNVGRGDTVAVLGCGGVGDAAIAASALAGARTVIAVDLDDRKLEWARRFGATHTVNAGAGDVVEAIRDLTDGFGADVVIEAVGRPETYRQAFFARDHAGTLVQVGVPTPELTIELPLIELFGRGGALKSSWYGDCLPSRDFPALIDLYLSGRLDLDGFVSETIGLDGVEEAFGRMQRGEVLRSVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH1</accession>
    <name>A0A7K0JQH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000231">
        <property type="protein sequence ID" value="MST32171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="14495" checksum="04C79782A809A08B" modified="2021-04-07" version="1">MLDARARDLARGTNFAAFTTLLPDGQPSTHVMWVDADDDHVLINTEVHRQKYRNVTRDPRVVVTVIDAGSPYSYAEIRGRVTRTVTGEEARAHIDRLSEKYQGTPYGVPIESERVLLEITPDRVRYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI6</accession>
    <name>A0A7K0JQI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl-ACP synthase II</fullName>
            <ecNumber evidence="4">2.3.1.179</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="406" mass="40739" checksum="7CA48ED716B07C0C" modified="2021-04-07" version="1">MRAVHATPGGGPAVAGRRVAVTGIGVVAPCGIGKDAFWAGLIGPAPTGDLRVEGLDAAAVYGPKEVRRVDPFTQFAAVAAAEAVDDAGGAEALAGDPDRAGVIIGTGIGGITSFEEQHTVLMERGARRVSPFLVPMMMGNRAAADLSMRYGFRGPCEATVTACAAGTHSVGNGARLVATGRCDVVLAGSAEAAMTPLSLAGFGNMTALSTSGVSRPFDARRDGFVMGEGGAVLVLEDLERAVARGARIYAELAGAASTADAYHITAPSPDGSGAVSCMELALADADLRPGDVTHINAHGTSTPKNDAAEAEAIAKVFGTPGPAVTSIKGITGHSLGAAGSLEAVALALTFAHRAIPPTAGWEIPDPDIHLDLVVGEPRAWEPGPAMSNSFGFGGHNGSVVMVPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ5</accession>
    <name>A0A7K0JQJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">GHK86_05735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000249">
        <property type="protein sequence ID" value="MST32225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="702" mass="77424" checksum="DBF2CFA40E23ED1A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN7</accession>
    <name>A0A7K0JQN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_05785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000250">
        <property type="protein sequence ID" value="MST32233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="480"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="598"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="688" mass="70387" checksum="6C7FE0964241764C" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT3</accession>
    <name>A0A7K0JQT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000265">
        <property type="protein sequence ID" value="MST32296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="29413" checksum="24451444B262B60E" modified="2021-04-07" version="1">MTPGDAEVGDGDRRLLDELARIAGRRIERLREYQREHHLADTLQRSLLPQALPAVRGVELAARYRPAQEAAAVGGDWYDALVLPDGRLLVMVGDVIGHDLNAAVAMGQLRHLLRAHALDAPDPAHLCETVNRLLPALGTGEMATVAVAHLDLDRGRGRVTITSAGHPPPVVVGAGGTASLLAVPACPPLGALDATPYESVQAILEPGATLVLYTDGLVERRGEPIDASLRRFATRCVALGDPSLDAALDGLLDDVLAPGTAADDVAVLAVRRSTTGGAPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY6</accession>
    <name>A0A7K0JQY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="2">
        <location>
            <begin position="172"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="36126" checksum="F52BAF08333190AB" modified="2021-04-07" version="1">MTRSRNTSIVFVASTGGHLVELLALSERLPVPADEALWVTFDTPQSRSLLSGRDVRFVRYAGPRDVMGALVNAAAATRIVRSRPLTHAFSTGASIAGSFLPVAAAHGIEAHYLESATRILGPSLTGRLLRLVPGVHLHSQSPAWADGTWPYAGSVFDGFVGVQGPPTPVRRVVVTVGSLAGFGFRRLVERLMDILPPDADVTWQIGATDVAGLGITRARATLPAHELQAELCRADVVVAHAGVGTALSALVAGRTPLLVPREQAYGEHVDDHQSQIASELQARGLAVARRVSDLDASDLVLAGNRRVQRAVSPPPLDLATLTRRRRRPSDRSHRAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR01</accession>
    <name>A0A7K0JR01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4242 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="10120" checksum="153E01219078A8AF" modified="2021-04-07" version="1">MPIFVVERRFADQLEASAERLDGINRINADEGVRWLFSFLSADKRKTYCLYEAPSPEAIRRAAQRADLPADVVTEVSGRLMPDGSPVPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR53</accession>
    <name>A0A7K0JR53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000286">
        <property type="protein sequence ID" value="MST32402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="16244" checksum="F48BAD081F8B22F0" modified="2021-04-07" version="1">MTTRPHFSLEGAGEPTAAGRFVDVDAIQPVAFVEGLDFRPVLGEQTMVNFVSFQPNTEAPRHVHVEEQIVIVLEGEFEFDIDGEVRMLRKGDVAVVPPWVPHGARTREVPCLEVDVFNPPRATLLEHARAQREVPADPGDADSAANPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG1</accession>
    <name>A0A7K0JRG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000320">
        <property type="protein sequence ID" value="MST32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="628" mass="65372" checksum="D07B4850F49DF9B5" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM5</accession>
    <name>A0A7K0JRM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000332">
        <property type="protein sequence ID" value="MST32567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="15355" checksum="4FC8D265D77704A9" modified="2021-04-07" version="1">MRATGRVLAGAAGVAAVALLVVGLARLSDATLTAWGTVAAVGIVAAGWAARQRLSSEPTVAVRPAAGGVEDRPFAGFEAARGRVASALETEDGFERSLQPYLQELVTARLGDGARDRLGERGWQLVFGPPPRQPGVAELEDLVRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN8</accession>
    <name>A0A7K0JRN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000338">
        <property type="protein sequence ID" value="MST32595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="5"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="234"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="622" mass="68997" checksum="599D5C213D517BF3" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ0</accession>
    <name>A0A7K0JRZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000365">
        <property type="protein sequence ID" value="MST32705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="12416" checksum="848BA6F3E7997D6F" modified="2021-04-07" version="1">MTTDIAGHLSWDATLRHGRNGRPWIRLGLVTTDGRQAIVKAFDTLAVTTAGLRSGTDIVATVGPARICEWTDTQGVKRSDVEYVAHRITVVDHPSHTGAVDRILRAESTDVLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS36</accession>
    <name>A0A7K0JS36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000371">
        <property type="protein sequence ID" value="MST32733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10624" checksum="D4C32B436E4C6766" modified="2021-04-07" version="1" fragment="single">MMWYWGGGVHWWAWLLGLVGMLAFWAVIVWAIWYFVSGMTGRPAEPPPASSDAKRILDERLARGEIDPEEYRRLLGVIHGDVGASADGRPPVSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS40</accession>
    <name>A0A7K0JS40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000381">
        <property type="protein sequence ID" value="MST32755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="346" mass="37853" checksum="A6449C013831855E" modified="2021-04-07" version="1">MSDASTLEPRVSVVMATYNGEKFLLEQLESIAAQTLAPLEVIIRDDGSSDDTLEIARRFASRSRCPVLVRESQGQRLGYAENFAKAASAARGDLVAFSDQDDIWHPAKLATAARVFSRSDVVLAVHRSYVVDETGAMTGRRFPAGKWSGTFGLDLPLDVFPGFSMVVRSRLLRAADYRQVSGPTGSRSANLSHDTWVWSVAPCLGSTVVLPDLLAWYRQHDAATVGERHRTFAERANYGDASRFREAARHNRHIACCLREMEAVWALTDGTAAERAEQMATARSELATVLAGRARIYEGESRIQGARTWFAMVSSGGYGRAIRRPSQGALVALKDLTKVALGDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS44</accession>
    <name>A0A7K0JS44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000383">
        <property type="protein sequence ID" value="MST32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="12517" checksum="C6AB5F42D379881A" modified="2021-04-07" version="1">MTMPTGGPGGKRPVQDSAHDWTVDVADRIESVVGTVRDKTTVPVVKIVRGVVFGLVAGPLAIVAGIFFLIGLFRLIEVYLPIEPYSARVWGTYAVAGAIFVLVGLFLFSKRTGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS80</accession>
    <name>A0A7K0JS80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_08695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000392">
        <property type="protein sequence ID" value="MST32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20357" checksum="0F8D613F46CD498D" modified="2021-04-07" version="1">MPTLAELAVEASTCTRCPLSAGRTQVVWGEGDPHARLMVVGEGPGREEDLQGRPFVGRSGQLLDRLLAEEAGLRREQVYIANVVKCRPPGNRDPLPAEIAACRPYLETQVELIGPEVVLTLGNFSTRLLLDTTEGITALRGRAYPWGPAGAVLVPTFHPAAALRGGGEVQARMRADFVRAKQILAGAATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC0</accession>
    <name>A0A7K0JSC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000408">
        <property type="protein sequence ID" value="MST32846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="15691" checksum="75ED24D490629229" modified="2021-04-07" version="1">TILGYWAAAHQRPTAPRRFLYPLGSGTLGYAWPAALGASLALPGAKVLAVVGDGGLSYGLAELATARQQGIDVALLVIDDGGYGILREYQSDAFGATHAVDLAGPDLVALAAAAGLPVRDGTPDSLADDLTWALGVPGPAVVVVRTHLVAAQPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD1</accession>
    <name>A0A7K0JSD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000413">
        <property type="protein sequence ID" value="MST32856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="24052" checksum="FBAB047D5459C15D" modified="2021-04-07" version="1">MGGRRRARPAARRHHPGARGAGPLRRRRRHRRLNRRAQWALVADCNDAGEAGVRVLDGIEVDILEDGGLDADRDLLAPLAVVVASVHSKLRMDAPAMTARLLRAVRDPAVDILGHCTGRMVTGRGRPPSSFDARRVFAACAEAGTAVEINARPERLDPPDELLAVAVDAGCLFSIDTDAHAPGQLDWAANGVRKAVACGVDPERVVTNWPLERLLAWTRAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL3</accession>
    <name>A0A7K0JSL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">porA</name>
        <name evidence="3" type="ORF">GHK86_09405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000436">
        <property type="protein sequence ID" value="MST32931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="41796" checksum="57DF4DEEB0A3E48C" modified="2021-04-07" version="1">MREQLEGSRAVAEAVIRCRPGVVCAYPITPQTHIVEALGVAVRTGALAPCTFLNAESELAALSALIGASVAGSRAYTATASQGLLYMAEAVYNAAGLELPLVMTVANRAIGAPINIWNDHSDAMALRDAGWVQLYAADTQEAVDLHLLAFRLAEAVSLPVMVCMDGFVLTHAVEEVDIPARGAVDRFLPPRPLNGRQVLDPDHPATIGTMVGPDAYTEVRFLAHRRLLRVLDVLPHLAADLAAATGRRVGLVRPYRLEGAETVVVAQGSVLGTLAEAVDALRDEGVAIGSLGVTAFRPFPDDEVAAVLAPARRVVVVDRALAPSRGGFLAAEVARSAPPAVPVIDVVAGLGGRPITRGELRRCLLDAVDGSLPPLHLLGLHPEALADELTGMGATGGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN3</accession>
    <name>A0A7K0JSN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">dnaA</name>
        <name evidence="14" type="ORF">GHK86_07590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000335">
        <property type="protein sequence ID" value="MST32584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="262"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST32584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="355" mass="40193" checksum="E333F645534F12C9" modified="2021-04-07" version="1">MVPRPLHGKGANVDLPSLNPRYVFDAFVIGASNRFAHAAAQRVAEMPAASYNPLFIHGDSGLGKTHLLHAIGHYVIENFPGRRVRYVSTETFMNDFVDAIRNSSQSTFKRRYRDCEVLLVDDIQFMEGKEGLQEEFFHTFNTLYEGSKQIVLSSDRHPRSIATLEDRLRSRFEWGLITDVQPPELETRLAILRKKAESEHTPIPDEVLELIAANVRDNIRELEGALIRVSAFASLNRATLTRATAEQVLADILDAGRPRQLTPAIILQEVSDAFGFSVEELIGPKRQRPLVRARQIGMYLFRDLTEYSYPAIGREFGGRDHTTVIHAVEKVTTFMKEDRQTYDQVTDLLAKLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ7</accession>
    <name>A0A7K0JSQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_07750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000344">
        <property type="protein sequence ID" value="MST32614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="8">
        <location>
            <begin position="34"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="7">
        <location>
            <begin position="610"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="814" mass="89617" checksum="5BE74CDCBEDF71AD" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR8</accession>
    <name>A0A7K0JSR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_09705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000449">
        <property type="protein sequence ID" value="MST32991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="28101" checksum="576182A8AEA2EB5D" modified="2021-04-07" version="1">MTYDLTLRIWRGDAAGGDVVDYTVSAEDGEVVLDAVHRVQAQLAGDLAVRWNCKAGKCGSCSAEVNGRPRLMCLARLSTFPRGDPIVITPLRTFPVVRDLVTDVSFNYRKAELVPAFEPTAEQPRAPFRMAQVDVERSQEFRKCIECWICQDTCHVIRDHEDNKPAFSGPRFFIRYAELDMHPNDARDRKKLAQEERGLGLCNITKCCTEVCPEGIKITDNGIIPMKERVVDVKYDPVRFLRRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT12</accession>
    <name>A0A7K0JT12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_10175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000476">
        <property type="protein sequence ID" value="MST33085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029570589" description="Cytochrome bc1 complex cytochrome b subunit" evidence="9">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="10">
        <location>
            <begin position="36"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="29227" checksum="489D219630CCD3CF" modified="2021-04-07" version="1" fragment="single">MFALFFAAIALPFVRTPRVAPAPEKQEAPEPEEPEVRTWTGAIRRAGLRVLPPGKLLPDFQPAYVASWAYVFGVGTLSALVVVVGSGLVLAVKGPGWWHLSTLGHFVNSVHLWSVELFMGFMAIHLWAKFWMAAWRGRRQATWITGVVCFLVAVFEAFTGYISQTNFDSQWIAFEAKDAFNAGGIGAIVNPMNFGQALMLHISLVPLALVLLVGVHILLVRARGVVPPIDARPEDLGVGGVPATTGPMARGRRSQPLAGAGSPRATSTAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT91</accession>
    <name>A0A7K0JT91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000497">
        <property type="protein sequence ID" value="MST33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="344" mass="37304" checksum="6678BA1C3C610656" modified="2021-04-07" version="1" fragment="single">MALGDRLDRFQRRHGWLGFPVAVLYKCLDDRATYLAANVTYYVLVSLFPLSLLFVSAAGFFLEGHPEIRSKLITSAAQLLPGIGAQIRKVLTGFKGNAVALAVGAAGTLYGGLGATTSAQCAFNQVYGVPRFEQPNPLVTRVRGLGLLVLIGLFILASTGLGVAAATTNDLSARYGPLPRAGVYVVTFLMDVALFSGAFQLLTAADLRFRNVLAGGVIAAGTWELLQTLGARYIAHLIAHDTAVYGAFGVVVGTIVWIYLEALALMIAAEVNVVHERRLWPRALWGQYVDGVDFTDGDRRCYRLYLEAWRFKGSQWVDMEGPPPRQPGASGPSRTAEGRRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB1</accession>
    <name>A0A7K0JTB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000504">
        <property type="protein sequence ID" value="MST33167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="393"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="708" mass="76916" checksum="8306F5B64EB9D5FB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE2</accession>
    <name>A0A7K0JTE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000509">
        <property type="protein sequence ID" value="MST33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="345" mass="34481" checksum="21809D4A6655B9F8" modified="2021-04-07" version="1">GLLQGAAGILGRARARVVLGAQNAGLAAASLLGALAPGFGLFAAARVLGALVSWPQHPVGSAYLSDRFPRRRATVLSWHTAGGSIGTVTVPLVVTAVIAVAGWRWALVALTGALALGALLVVAALPSEHHTDADVATAGERPSLRALLRTPGVGVALAASTIAAGGRGLGTLSTYVPADLRSGLRLPALTVGAVFTVVMAASVAGPVVGGSLADRFGRKRTLVVTYYAAAAAVCAFGFAGPNLAALVPLGLLMGFLAYAESPLLQALFSDLVGPGRSRSAFGTFFAVAYGVGALWTALLGWIITVAGFPAAFCTMAASFVVAGSVIALGLRAPRAGGVTLEAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE6</accession>
    <name>A0A7K0JTE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_08700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000392">
        <property type="protein sequence ID" value="MST32799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="351"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="596" mass="64910" checksum="5AE2515F66C35A44" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF0</accession>
    <name>A0A7K0JTF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">GHK86_10730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000513">
        <property type="protein sequence ID" value="MST33193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="347" mass="36790" checksum="0D6F5CBC4720D250" modified="2021-04-07" version="1">MSDNLFSGFFGRDMAVDLGTANTLVYVRGRGIVLNEPSVVAVNVKDDRPLAVGADAKRMIGRTPNHIQAIRPLRDGVIANFDICEKMLAYFIRKVHGTHRFSAKPRMVICVPSGITGVEQRAVQEAAESAGARKPAHIIEEPMAAAIGAGLPVHEPTGNMVVDIGGGTTEVAVISLGGIVTSQSVRIGGDELDEAIIQFIKKEYSLALGERTAEEIKIALGSACPLEEELHAEIRGRDLITGLPKTIVTSTEEIREAIEEPVSAIVDAVKVTLDKTPPELAADIMEQGIVLTGGGALLHGLDARLMAETGMPIVIADNPLHSVVIGSGQCLEEFEALKAVLMSANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI8</accession>
    <name>A0A7K0JTI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000534">
        <property type="protein sequence ID" value="MST33247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="10151" checksum="11C293E279AE4744" modified="2021-04-07" version="1">MSTATAPITKPIAPVSRAVLRPVDPGNDASCAHCGEPVKFAARHQRRQVIANVYVNARWNRVEHFHEDCYEAAGAPYGGITESSEPLPRRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT0</accession>
    <name>A0A7K0JTT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_11505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000565">
        <property type="protein sequence ID" value="MST33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="357" mass="40232" checksum="CEAAD74040204D3D" modified="2021-04-07" version="1">GRRAGHVGGQREHRHRDHRRTPGRPPPPSRRPGRRRAGRDPQPPTPLRAKGPPVNLLLQHWSFDPFLIGVAAVVALHEQGLHNLARRSRPARTAARRRRAWAFYGGLALLAITVTSPIDYWAYHYFTVHMVEHLLLMFGVPMLVVYGAPWIPLLHGLPVGVRRRAGRSLVLGRWASPLRAVGRVVRSPAFAIVGFNVVMVLWHLPGPFDLAERDQTVHIWLMHGSFVGFGTLFWLQFIRSRPFSLPLSPARRAQALFLTNVVMFFLAMALSIFSSHPWYAAYAHVSHPGLSRMADQDLGAAILWVCGDFWAFPTFVRAVQAYIDEDRRPAFAFRPGGRPLVRTTPSGVVVSRNRSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT4</accession>
    <name>A0A7K0JTT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000437">
        <property type="protein sequence ID" value="MST32939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="19561" checksum="786980B93F42D128" modified="2021-04-07" version="1" fragment="single">MEAEDGREDDGPLFAWLPPEDRLWRHPSEVGASAAERAASVWRRSPGARVWTVALVAGVFGAILASGVGLATGLFVQHTVTVPVPLPARSTSAATTTSAQEPANSWPAIANEVAPSVVGITAGGQTASGVIYEAYQDSTYVITAADVVAGSRRVGILWDNGTRGRGYVVGADPASGIAVVRVAGAGHHPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU00</accession>
    <name>A0A7K0JU00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000589">
        <property type="protein sequence ID" value="MST33425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="341"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="544" mass="58363" checksum="1925718F0E5E85A1" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU63</accession>
    <name>A0A7K0JU63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000601">
        <property type="protein sequence ID" value="MST33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8445" checksum="947604D40C117272" modified="2021-04-07" version="1" fragment="single">MERLDEREPAGAVEEVRLGPTVAVGGDGIGRLADGRVVFVAGALPGERAEVELVEQRRDYARGRLRRVLDAAPGRVAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU80</accession>
    <name>A0A7K0JU80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000613">
        <property type="protein sequence ID" value="MST33488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16982" checksum="BC40B39ECDBF5453" modified="2021-04-07" version="1">MPGLEDLYREIILDHYRNPRNRGELPVPPAHAETGFNPLCGDEITVYVQLEDGAITDLKLAGQGCSISQSSASMMSTAVKGKTLEEARRVIQTFKGMMSVHEQRLGGEDADGAADAIRELGDLAALQGVVKFPVRIKCATLSWNTLTQALDAVSAPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB6</accession>
    <name>A0A7K0JUB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-binding glutamate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000633">
        <property type="protein sequence ID" value="MST33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="33995" checksum="D8C7DE407F628C4C" modified="2021-04-07" version="1" fragment="single">MEDQVAQRNIIGHSNIFTPDVINDIHVKSELGRYRMRGFSMFKPIPHWDQLMFMPGTLTRFVIEGYREKCETKTVLGARFAKNPIELDIPVYITGMSFGALSLEAKMALAKGASMAGTATCSGEGGMIPPERDLSTKWYYQCIQSRYGFNPHHLMLADACEFFIGQGCKVGLGGHLMGQKVTEQVAEMRSLPAGIDQRSPARHPDWLGPDDLSLKIQEIREATDYQIPIQLKLGAARVYDDVRMAAKCGPDIIYLDGAEGGTGAGPHIASEETGIPLMAAIPEARRALEDVGLADDIDLVVAGGIRNGGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL0</accession>
    <name>A0A7K0JUL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000517">
        <property type="protein sequence ID" value="MST33199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="25056" checksum="76A6910E6558252C" modified="2021-04-07" version="1">KAPLPAPLSTTDVALTWAFAELGVPYLWGGTGAGGFDCSGLTQYVWGKAGVSIPRVAAAQYAWTDPVPLSQLTPGDLVFYGHGYIHHVGIYIGDGLMINAPYTGTVVQVSSIWWSDLAGFGRVHADGTPTASRQVPTPADPIRRVVRSEKPVPSESKPPPGWKPPKHVQHRASSPTSTSAPSTTTAPPSTSTTAPPSTATTSTTSTTTAPSTTSSTQSSAGDPNPSSTTTSPASGSTGPGSGSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN8</accession>
    <name>A0A7K0JUN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_13180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000682">
        <property type="protein sequence ID" value="MST33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="157"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="23912" checksum="3CA45FA48CE919F1" modified="2021-04-07" version="1">PADGCSAGVVPLAGEGEWAAYLEHLGRGATRIGPGTFSKLAADQVVELPPDGAEALLLEAFVDTDRVSVVPGEGGSTRLAWEPTGNGWIEVTVGVLGAPGALRALSPSMTIATAGVLSLEEKFMGGTGVNITPPPAPPLGRVRPEAVDAARRRIEAVAEALGIAGYARIDAFVHADSGEVVVIEANTLPGLTPSTVLYHQALAEQPPLYPRQLLERIIELGLARRAVPVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV36</accession>
    <name>A0A7K0JV36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000573">
        <property type="protein sequence ID" value="MST33359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="36545" checksum="EAE067FEBC074F6A" modified="2021-04-07" version="1">MRIAVTGAAGFIGAKVVTELLDRGHEIVAIDNFDTTYSAELKHERISRLEQREGFHLITGDIRDERDVRRMFDPRPDAVVHLAAQGGLRKSMDEPAAFISANISGFGNVIKATVDAGVGTMVYASSGAVYGGTPGLPFREEDAAAFPLSLYGATKRCDELLAFTYAHGAGLRCTGLRFSTVYGTDGRPDMAMYTFARRINEGQPIQVHGHGKMVRDFVWGDDVARAVVLAVEDTSEFSTTPAAGGPRVEVASAPWRVLNVATGRQVELMEMIRLVEAAVGKQAELVLIDALAAEVRENRMDVSLLGETLGFVPTVQVEEGIPQAVRWYLDYLARLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV54</accession>
    <name>A0A7K0JV54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000737">
        <property type="protein sequence ID" value="MST33821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="26"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25914" checksum="02168800B440C619" modified="2021-04-07" version="1" fragment="single">MVSVPTTRGAGATPLVRRSARRGLRTDIQGMRAVAVLLVIADHAGVPGFGGGYVGVDVFFVISGYVITQLLLRETGKGLRLGLADFYARRVRRIAPAATATLVGTVLAAGFLLGHRASPDLPGDIRWASLFAANFRLIRTGSNYFVAGVQPSLITQFWSLAVEEQFYLVYPLLVFLAAAVAGPRYRRRVLAVALAALVGASAWWSVHLTAAEPAVAYYSPFTRFWELGLGCLLAVVTAGRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB3</accession>
    <name>A0A7K0JVB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000759">
        <property type="protein sequence ID" value="MST33881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="28"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="18927" checksum="8003F2B9AE555978" modified="2021-04-07" version="1">MARRLEGTETPPVGRRHAGRLVARTVPMRGRMLLCHDGSAGSRHAIAVVADLVGPPPEALVLTVWLPVYLRLAVSVSFGPLPLSDEPELDRHEADNAQLIAEEGARLAGQHGVEAKALAEPAHQSVGHTILEVADRLDIALIVCGQRGRGPMSAAGLGSVTQAVAIHSRRPVLVVPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB8</accession>
    <name>A0A7K0JVB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_14355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000765">
        <property type="protein sequence ID" value="MST33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029576682" description="DNA_binding_1 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="3">
        <location>
            <begin position="106"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="180" mass="18632" checksum="F9F053138F75B8C2" modified="2021-04-07" version="1" fragment="single">MPGFVPAHPRHPNPSMASAGPPTRGSHTASGSNSAARRITAAASGRTSPTASKPSSARRSTVARPKPESAPVTSTGRDRPGAGIARRVPGDRRRQPPGYLPCVPADFRDRVLAALASVHPGEVVSYGDLAAQAGYPGAARGVGAVLAGSTPDQRLAWWRVVYADGRLAPGHEPEQARRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD7</accession>
    <name>A0A7K0JVD7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proton_antipo_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000772">
        <property type="protein sequence ID" value="MST33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="6">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="8726" checksum="0C6E1D737207AAC2" modified="2021-04-07" version="1" fragment="single">RGHAACSWAGAAAAVVVAALVVIRGAARFSVLGAEAVADPLTALLLVLVTGVGALVQSYSTRYLQADPTAYRFAGWVGLVVAAMGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH5</accession>
    <name>A0A7K0JVH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000792">
        <property type="protein sequence ID" value="MST33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8512" checksum="6963046B60D7FFA7" modified="2021-04-07" version="1" fragment="single">MMLLGSLPPADEPVPFVARHRPGAVTAALSGSGLGPGAVVLPFPRPLLYETWVRFGLPPLALGAAPLRSVDVVHAPSVAVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI6</accession>
    <name>A0A7K0JVI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000795">
        <property type="protein sequence ID" value="MST33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HDOD" evidence="2">
        <location>
            <begin position="196"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="43057" checksum="70CB72FE2B717363" modified="2021-04-07" version="1">MMAGRFMVGRQPIFDESYGVVGYELLFRGDPTAEPGDDAMTSEILVRTALDLGLSGVVGDKRAFLKASRAFLVGDLDLPLPPERVVLEVGGRLAGDDAVVEGCRRLAELGFTIAVDERGEGTGAILDVASLAKLDVLALTPQELAGHVERLHGRGLQLVAENIETVEQLADCRRLGVALFQGYLLSRPQVVHGQDLTPARMTILRLIGKVCNPETSTRELERIVEGDPALSYRLLRVAGAGASAGLRRGVRSIREGVVLLGRQRLRSWLVLMLAADSSGATDEQVSIALTRAKMCELLAVEVDPTLRDSAFTVGLVSALDLLLQGSLAGLVAHLNLADDLVEAILDHSGPLGRILADTLDWQLGQPPRELRSETDLRVAEKGYVEALHWTTGLFAALQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ9</accession>
    <name>A0A7K0JVJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000786">
        <property type="protein sequence ID" value="MST33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="86" mass="8564" checksum="01112F40560EA2EC" modified="2021-04-07" version="1" fragment="single">MPTVLVVSDAEVRRLLDVGELAVALEEALVALAAGRASVPPRVAARTPAGLLGSMPGYVPGVGLAAKLVSVYPANPAAGLPSHQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU6</accession>
    <name>A0A7K0JVU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000838">
        <property type="protein sequence ID" value="MST34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="9586" checksum="2A7AED356C421843" modified="2021-04-07" version="1" fragment="single">MSAGRVAGTTDAAGTCPGCGRTHPVPSTRVVIGGDALDALGAFLGERAWGHVVVVSDANTDAALADTLARRLAGAGRRVTRCRFPQRSGLVADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ4</accession>
    <name>A0A7K0JVZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000861">
        <property type="protein sequence ID" value="MST34126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="32704" checksum="F82D937D2E1AA72B" modified="2021-04-07" version="1" fragment="single">MDRLRALGVGRDWMSGAELLDDPATFPRFVAARLAYRMLGRWAWLLLVPVVVSIVLRLPAFLLATAHGLGHHSPRALILLSATLVELVLLALIGGGAMRRSWRALSGVSLGTDSREPNRAARDRARALIAEGYHGFVSGHTCRAEVTDLVGGFYANPGCVADVVTEQQPRVPGLGLPPAFLAHRQVSWLELEAGSELHVRLLLARAPLPGSTLGERLATRPLQSVGGRDLRPELVATFPHGASWPVQPSGQLRRRRVRRWSALFVAVSALVSLISAFSEPLRDRLTLIRDVLPIAVPEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW16</accession>
    <name>A0A7K0JW16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000869">
        <property type="protein sequence ID" value="MST34146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="32069" checksum="D5A38640553DCF8D" modified="2021-04-07" version="1">MASPSVHPRLRRNSPCAVAGADCVAIVALPCVTTGSCRSPLHVPPKPIGRSASGQRHPAAMCRPADVRRIVRLSPARPGAAGPAAVDHGAMARGRGPAGDRSTAERILAAAAELFARKGFHATTTREIAAAVGVRGASVYHHFPSKSEILYEIARRTMEDLLALGRQAVASSAEPERQLRRLVEWHVHYHADRRVQARVADEHLDALPPARRAEVVALRDEYEGLFRSVLAAGRDRRDWPVDDVAVTTFAIATMASGVGAWFREGGRLSPAAVASIYGDLAVRAVGCERAGAPLPAAGAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW83</accession>
    <name>A0A7K0JW83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_15945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000897">
        <property type="protein sequence ID" value="MST34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="213"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="451" mass="48815" checksum="E68037D6F75B88A3" modified="2021-04-07" version="1">MGRFFRSIRTRLLVATLLPAVLLLVGTFFAFNAIELSHQTQRDVQIADKVASAIGDALEQQPRAPIDYRVFQEILGTSELTVTRAGRTLYQSPTRLPRRSQVVQEHFEPGGLITIRTDIDTETGLTLKLTAVAAVALGLIVLVGLLATMLVMRAISEPVARAVRVADRLAGGDLDARMGATGDAQFNRLAHAFDDMAERIQETDTVQEQFLSDLAHEIATPINGVVGLARGALDQTIQPEGLAEAGQLLEEEAARLDKLLADLRQLRMPTLASAPDWQWVRVDRLVEALGRRFAPDAERAGLELVTRTRRIDLVSDPHLIERVVTNFLTNALRYTPAGGTVTLQLRRSHQEAVISVADTGVGISAEAQGRIFDRFYRADNSRDRVSGGTGLGLAIARRAAAALGARIELDSRPGEGSEFRLVLPVAPPEHPAPNDPPAGASRATVQAPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH9</accession>
    <name>A0A7K0JWH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000931">
        <property type="protein sequence ID" value="MST34293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="18595" checksum="C65C43C61B45B685" modified="2021-04-07" version="1">MALEIRPVRPAEHAAAGALVVAAYRALDGLPLDDGYAAELADVGRRAAQTEVLVAVDGGRLAGCVTFVADASSPWAEDLEPGEASIRMLAVDPAAQGRGVGRALLSACLARATVLGRAAVFLHSTPWMTAAHRLYRDAGFVRVPDRDWQPHPDVPLLAFRLPLAGTPGGGVAAEGSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV5</accession>
    <name>A0A7K0JWV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001002">
        <property type="protein sequence ID" value="MST34428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="481" mass="50379" checksum="925875BFDF41F026" modified="2021-04-07" version="1">MADAPGDVQLFVDGSYTPGSGSDRYPVRSPVTGELIGSVPVPTAADLDAAVAAARAAQRGWARTNVWERARICHAIGDALAARVEELARLQTLEQGKPLAESRGDITEAATLFHLHAEDAVRLTGETIASTDSGKRMWTFYRPVGTWGIITPWNFPLLMFAEFVAPGLATGNAHVVKPPAHTSFTVLAAMSVLADAGLPHGLVSVLPGEGPTGAALVAHPGIDAIGFIGSSATGAAIQASAGLKRSIMECSGNGPLVVLADADLEAAAKAAVYGAYVCSGQVCCATERVVVDASVRREFVDAVVAAADEVRLGDPFDAATNLGPLNNEGVAAKMDRHVADGEQRGAKLLRGGRRRADAPTDLYYEFTVIDGVSPDSLLATDESFGPVVPVLAADGDDAILELANRDRLGLQAAVFTRDLSRAYRFVEELETGQVVVNDSTCWWDINMPFGGAGGRRTGWGRIGGKHTLLGMTDLRTGAIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX20</accession>
    <name>A0A7K0JX20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000852">
        <property type="protein sequence ID" value="MST34104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="299" mass="31427" checksum="1EA7C0F0D2910838" modified="2021-04-07" version="1">MLRFDLDEVREIRGRRPEAIAEAAARRRRRPLLGDDGRLLIVAADHPARGALGVGRDPWAMADRAELLRRLAVCLARPGVDGVLATPDVLEDLLLLGALEGKVVFASMNRGGLQGAAFELDDRFTAADAGTIAAMGFDGGKMLCRIDPSDPGSLATLEACAQAITALAARELTAMVEPFMSRVEDGRVRNVLTTEAVIRSVAITGGLGATSARTWLKLPVVDDMEAVMAATTLPTLLLGGDPAAAPTDTLARWEKALRVPGVRGLVIGRALLYPPDGHAEAVVDRLAELVHPAAGAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX72</accession>
    <name>A0A7K0JX72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydantoinase/oxoprolinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000874">
        <property type="protein sequence ID" value="MST34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="31810" checksum="F6F42BBA90E96D5E" modified="2021-04-07" version="1">GGEMTLDAGAATAAVQRIADAMGLPDARTAAAGIVDIVNENMFGALRLVSVQQGYDPRDFALVAFGGAGPLHANALGRLMGSWPVIVPPSPGVLCAYGDATTSLRNEAARTFIRRFSETSDAEVAAGLRELATEARSVLDEEGVAGDEQQVSWQVDVRYQGQGFEVPVEVEPVLLDAPGALDEIGRRFDAEHRRLFMFDLDAEHEVVNLRAVVQARPAHVAAPELASGGPDPSPARTDTTSVWIDGTELEAGLYDRARLLAGNLVPGPAVITEMDSTTLVLPGHAATVDRIGNLVIRPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA5</accession>
    <name>A0A7K0JXA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_15740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000881">
        <property type="protein sequence ID" value="MST34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="167" mass="18366" checksum="5B1A91F55E1F9CBA" modified="2021-04-07" version="1">MRGRIRAARALLVTPEGRKMFRYSMASVVSVVVSVAFLVLFDGVFRWGAVISSTLATAIATIPSYELNRKWAWGRSGRGHLWREVVPFWVLAFIGWGFSTYSVKLTESALAHSGLAHLLRTGLIAVVYIAAFGVLWIVKFIIFNKVLFANRAAELPPALDGRSGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD6</accession>
    <name>A0A7K0JXD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000893">
        <property type="protein sequence ID" value="MST34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="28087" checksum="005C43D2E22E2E60" modified="2021-04-07" version="1" fragment="single">MVTARPPTIGRETFMPYLRPPYFRAEVLLAGLRDTLTAGRPDPDWVTTDPPVFLIGCGRSGTTILGQLLGRHPAIDHRHEPYAAWAAIDPRTDFLHAYTATAGRALLDRGDATARERRRFATILRPAPGRRLLEKTPINALRVGYLQALAPGATFVHLVRDGVEVSRSIAAVAAHTVRYAGRGSFNRWWGVEDAKWRCLTRDAAVAGHPAADGLTDDLQRGAYEWLVSLGEVDRHRRELDGHLVEVRYDQLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF9</accession>
    <name>A0A7K0JXF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000901">
        <property type="protein sequence ID" value="MST34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="7988" checksum="DC8B32DFDB3754BF" modified="2021-04-07" version="1">AAWAKAPAGERLHLAVMHALDRPGADALLAELRGRVEPATSFVGSFSPVMVAHTGPGLLGLAWWWETERDRAGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH4</accession>
    <name>A0A7K0JXH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_18220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="WJHE01001126">
        <property type="protein sequence ID" value="MST34651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="398"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="584" mass="63421" checksum="6DB569F992EBB4D2" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ9</accession>
    <name>A0A7K0JXJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000920">
        <property type="protein sequence ID" value="MST34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="20290" checksum="21B9C3DFF8EB37D5" modified="2021-04-07" version="1">GLWDGAALIAEAAGRGAYVGYSMGGRFALHVALGRPDVVERLVLVSATGGIDDPAERVARVASDEGIARRIERDGVPAFLDWWLERPLFATLPPEAAALDARLGGTPEGLASSLRLAGAGRQEPLWDRLAAIEQPVLVVAGELDDAYLARAHRLVDAIGANARLAVIPGAGHACHLERPDAWLAAVGPFLAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ6</accession>
    <name>A0A7K0JXQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001188">
        <property type="protein sequence ID" value="MST34741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="473" mass="50556" checksum="9C096F4444F920E1" modified="2021-04-07" version="1">MGSNRQDRYPRTGRARDAVDYAAVFLAVVTPLAVITPDLTVADANEAYLATVERTQEEVIGTPLFELLPPDGTDKRAVEGPEALRSSLLEVLRTGKPDVMDVLRYPVRDQRTGKFRDRFFAPVNVPILDGSGHVALVLHHAEEVTSYVGGDFDRARGLAGGSVPPGYAHTRDLVRRNRRLALQASHDRVVSRVLQDAMLTALPEPDDLALVARYIANTEADQVGGDWYDAAVLPSGSTMVAIGDVVGHDIRAAAGMGQLRGLLRALAWDREESPASILTRVDRAMPGLRIDTLATAILGSIESLGTSGSRQLRWSNAGHPPPLLVAGDGTVEILETDNDLPLGAGLGTPRSDHIHRLAPGSTLFFYTDGLVERRNRSREVGVARLSGALRRCHHLPLDEILDEVIAAVAGNAPEDDIAVLAICVAPTDRCSESEPHPRGGPAGAGTRGTRRARPCSVDSCVSAEGDPIPRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV1</accession>
    <name>A0A7K0JXV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000962">
        <property type="protein sequence ID" value="MST34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029624344" evidence="1">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="16237" checksum="044EEE64F08E9E41" modified="2021-04-07" version="1">MKMGKRVAALVAAGLAATASGVVAPATAGVAVAATSHPAVAATARTVWVRDCPGDRFRVEPKAFVLTCADANTAMTGITWKGWGTAHAVGHGTLVENTCTPSCVAGRFESEPAKITLSHLGRRAGHRDYGHVFVRPLRPNRHHFRVFSSKLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY7</accession>
    <name>A0A7K0JXY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001242">
        <property type="protein sequence ID" value="MST34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="49"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="15750" checksum="5D855B7E2B3565F5" modified="2021-04-07" version="1">MAPVPVAPSGATGRKARTGSSGCAPEPRGVRTANFADVVEQPFPGETGFSVERHEDGDAVVLALGGELDLETAPGLRHRLQEAIAERPGTVVVDLEGLAFLDSTGISVLVEALKQCERQGGRLLLRRPSPAIHRVLEITGLLELFGLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY8</accession>
    <name>A0A7K0JXY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001243">
        <property type="protein sequence ID" value="MST34831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="197" mass="20864" checksum="DB98BB87BB313B1C" modified="2021-04-07" version="1" fragment="single">MSGAERPTLRIEGLTAEIGGRPILRGIDLEVGAGEVHAVMGPNGAGKSTLSHVLMGRSGYTVTGGRVLLDGVDLLPLATWERAKAGLFLGMQYPIEVPGVSLEDALGEAFAAVGRDRGEVVALLEAEAGRVGLDRRFLDRPLNVDLSGGERKRNETVQLGVLRPRFAILDELDSGLDVDALRAVSRRVEAATEETGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY42</accession>
    <name>A0A7K0JY42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine-5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_19335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001265">
        <property type="protein sequence ID" value="MST34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17263" checksum="4B02755AE6DC3930" modified="2021-04-07" version="1" fragment="single">MPEPTELRSRLALALDVDDQVAAMRLARELHPWFGVAKVGLELFSAAGPDIVAQLVDEGYRVFLDLKLHDIPTTVGKAARVLGALGVTYLTAHAFGGAAMLRAAVDGLTDGAAGAGLESPGVLAVTILTSDDGAPPHILGKRVATAVEARCAGFVCAASDVAEAKHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY46</accession>
    <name>A0A7K0JY46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001277">
        <property type="protein sequence ID" value="MST34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="55"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="26295" checksum="A1A0CF78FA52F1A6" modified="2021-04-07" version="1">LRRWPVVHLDAPPGVPKLLGAEPLDLVRLCLPRRAFPYARFDVAGIEHVPRRGPVIVAANHRSYFDVVAVGLTVLEAGRHPRGLAKKELFDAPLIGPLMAAAGSIRVDRQGDPSAALAEAEQALHAGECLVVMPQGTIPQGEAFFDPHLSGKTGVARLAAATGAPVVPLGVWGSEAVWPRSSRLPRVANVAHPPTVRVRVGPPVRGLTGGDARADTEVIMGAIADLLPPEGRLPRIPTAEELARTMPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY51</accession>
    <name>A0A7K0JY51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_19340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001266">
        <property type="protein sequence ID" value="MST34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="37"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="356" mass="38418" checksum="2E38B4F4DAAB6385" modified="2021-04-07" version="1" fragment="single">GASPTLVVGDGPGSAHDAPADALAARRAELASAPVLVEIDHLVKEFPVRSGMRRQVASVKAVSDVSFTIRQGETLGLVGESGCGKTTLGRMVSALERPTAGTVRLGGDELLRLRGGDLRRRRGELQLMFQDPYASLNPRMRVGEIVREPLAVQGVGDRRQQWERVASLLDEVGLSRRAVELYPHEFSGGQRQRIGLARALSLSPRLVVADEPVSALDVSIQSQILNLMKALQRNHGLTYLVISHDLAVLRYLSDTIGVMYLGKLVELGPADRIYSRPAHPYTHGLIQAIPVPDPATERAKRSAAVRGELPSAVNPPSGCRFRTRCPLAQEICAAETPPLRVHGPGHVAACHFPLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY95</accession>
    <name>A0A7K0JY95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_17450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001040">
        <property type="protein sequence ID" value="MST34499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="5">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="528" mass="57142" checksum="B64FDC86C5830CDD" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH2</accession>
    <name>A0A7K0JYH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001361">
        <property type="protein sequence ID" value="MST35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="180" mass="18770" checksum="18C53C2F1BDDC28D" modified="2021-04-07" version="1">ATLGAPHLRVFAPPYTGGDVTVELAALRSTLAAVAARARAAGVRLLVELSPGTLLPGPAWFLLVADGLDEASVGVVYDPGSMLMEGHVRPTLTVAALGDRVGHVHVKDVAPRREPPGWRWDHVPLGEGMVPWTEVTRALAGAGYAGWLVVDHLGGEPTAAQLRADVAALRDLLDSSDGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM3</accession>
    <name>A0A7K0JYM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001340">
        <property type="protein sequence ID" value="MST34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="19898" checksum="19AB7F4ECC3721F1" modified="2021-04-07" version="1" fragment="single">MGSSRSAGPDGAASRRADHPSSGQAGPVDRPPGRAASVSVRPLTVGDASTAVRLHLDVLGAEFISRLGPPFLRAYYRAWIEAEDALALAATGPTGTIDGILLGAVDPSAHTAAMVRRRWPSLVGHLVVAATRDPRLARDLVVTRAVRYVKGLARVARRPRRHLPAPTPTPRADAPAGGTGEITHLLVAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR4</accession>
    <name>A0A7K0JYR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_20460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001421">
        <property type="protein sequence ID" value="MST35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004586">
        <property type="entry name" value="RecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF23">
        <property type="entry name" value="PTHR11070:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="30064" checksum="560A2EDCC614523D" modified="2021-04-07" version="1">MTVTTTHGFCQLVLAGLGSAGDLDVGATLLEDPDDLLEEVVADLYLRRAEWDHARPPFGFAAARAAAAAAVANPDALLVPDPAEGYLLSRLAHGARKGLAERLQDANLLTYDHVLTRLAATLGDPARGAAACARLQQRYQVVLVDEFQDTDPVQWEVLRRAFGTGDTTLVLIGDPKQAIYAFRGADVHAYLAAHRQARRFTLGANWRADQPLLDAIDALLSPLQLGHPAIRFRPVEAPAAHCRAGLLDAPVSVPLRVRLVPDRHAELPRTPASTVRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU9</accession>
    <name>A0A7K0JYU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001394">
        <property type="protein sequence ID" value="MST35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="243" mass="23801" checksum="C27248F04D0BA0A1" modified="2021-04-07" version="1" fragment="single">MAAGRLAAHALAEACLERVGAVDHAGAALRSVLSVDPTAPAQAAAADRRHRDGERSPLLGVPVLVKDNIDVGGQPTTAGSLALEGSLAPGDAPLVARLREAGAVILGKANLTEWANFMAEDMPSGYSALGGQTLNPYDASITPSGSSSGSAAAVAAGVAALAVGTETNGSILSPARHCSVVGVKPTVGLVSRRGIVPIAGSQDTAGPLARSVRDAAVLLGVLAGPDPGDPATAGAPVGVDYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB3</accession>
    <name>A0A7K0JZB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001530">
        <property type="protein sequence ID" value="MST35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="34"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="32965" checksum="F4855D1AF69B6EEA" modified="2021-04-07" version="1" fragment="single">EVLQDAGVGAWVAGDGGLQPLGPPGRPGEPGRGAALVLASSGTTGRPKLIPLTEAQLLHTARGVVCHHGFTGADRGYSPLPLFHINGLVVGVLASLVGGYPLVVDRRFSASTFWDVVAREGVTWVNLVPAILAVLATVEPPPAEVVARVTFARSASAPLPVPTLERFERRTGIPVVETYGMTEAASQITANPRPPGERRPGSVGLPVGLELRVADRDGRPLPPGEIGQVEIRGDNVVDAYWEPAGTRPAERPARRPDGWLPTGDLGRLDGDGYLFLAGRADDVINRGGEKVYPREIEDVLLADADVAAAAVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG2</accession>
    <name>A0A7K0JZG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001569">
        <property type="protein sequence ID" value="MST35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="20690" checksum="9BEE639E22444AB5" modified="2021-04-07" version="1">TPAVLDELDRLGVRATFFVLGSQVRRAGALTAELVDRGHELGVHGDTHTNHLKRPWWWVTDDLRRARDLVEGAAGTEVRWFRPPYGAYAASSIVGARQVGLQTVLWTTWGKDWRPGIEADDVVGMVRATMRRGATVLLHDSDVTSAPDSWKRTLAALPVLVEDWQGAGLSVGPLREHGVGSGRRSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI3</accession>
    <name>A0A7K0JZI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001602">
        <property type="protein sequence ID" value="MST35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10213" checksum="B61542E018A6C489" modified="2021-04-07" version="1">EDTVVVTRDLVERAKPDPHLFLAAASLLGVDPRHSFVVGDSVWDLLAAQRAGALGVGLLSGGYGRAELQAAGAYRVYADPAEMLDRLEEVGVRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZN4</accession>
    <name>A0A7K0JZN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001696">
        <property type="protein sequence ID" value="MST35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="24552" checksum="D6F449809CB41B09" modified="2021-04-07" version="1" fragment="single">MSAHRGASGCRPENTMAAFRAGVAAGADAVELDVHATADHHLVVIHDYDLARTTDGDGLVHERTLAEVRALSAGRWYDEAYAAERVPLLAEVLALPGVELEVELKGLPSERLVDGVCRAVEASGAAGRVQVTGAEHMVVAEVKRRLPAVTAGLFLPPREPGIPAAAYQRLVEESAAFGGFAVVHGRLSGLRALDLGRLHARGLAVQAGDVSGRAEILEAVGLGVDRLSTGDPAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0U0</accession>
    <name>A0A7K0K0U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="1" type="ORF">GHK86_21885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001675">
        <property type="protein sequence ID" value="MST35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="7702" checksum="A21793B5C480B38C" modified="2021-04-07" version="1" fragment="single">MLRCGLTGGIGSGKSTVAAGLVARGAALVDADAIARAVVEPGGPAYAPVVARFGPGVVGADGRLDRAALAAVVFADAAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU6</accession>
    <name>A0A7K0JMU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000013">
        <property type="protein sequence ID" value="MST31171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="18483" checksum="5BF2F4155B48E787" modified="2021-04-07" version="1">MADFDAGRRTTPVTRLLLAVGRTRGFARVYRVIGPVLDPWVLRRSRGRVASRVYGLPALLLTTVGRRSGQARVSPLLYLRDGQDFIVVGTNFGQEHHPGWTANLLARPDAEIEVGPERVTVTAELVDGAAWGQLWARFVDLYPGYANYLERAGRTPRMFRLRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW1</accession>
    <name>A0A7K0JMW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase (AMP-forming)</fullName>
            <ecNumber evidence="4">6.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000033">
        <property type="protein sequence ID" value="MST31296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="204" mass="21547" checksum="C7AD9CDF3C4CE0ED" modified="2021-04-07" version="1">PRGSIGRAVRCSRWMNTVPATTVHVAGLGERWEGAERPGHFDGVATIVAKLLGLAGRCLAFFGEKDYQQLAVIRRLVQDLSLPVGIVGCPTVRDPDGLALSSRNAYLDPGERAAAPRLYAALLAGRRAVEEDGALRPAEVAAAMAAVLADEPRFALDYAAVVRPDDLTVPPAIAGDVRLLVAARLGGTRLIDNLPASSPHREDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMZ6</accession>
    <name>A0A7K0JMZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000040">
        <property type="protein sequence ID" value="MST31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14625" checksum="DB9D9A1556EB7192" modified="2021-04-07" version="1">MVESDATVEAWRRVRALTQGPEALAPANAVAERAGITPTLARALVALTADRPTSMRELAGALRCDASYVTAVVDGLEQHGLARRTAHPTDRRIKVVELTAEGAALAGRLQAALDVAPEALRALSPTDLQALLRVLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN36</accession>
    <name>A0A7K0JN36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000042">
        <property type="protein sequence ID" value="MST31348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13243" checksum="3BFADF98B801B92A" modified="2021-04-07" version="1">MILLDQCLSIDLVPILAGAGHDVVHLRHRGMQRAEDPAVLDLARTERRVLLSVDTDSGTLLARTGASSPSVILFRRSTGRRPTAQTAIGLANLPRVAEALDQGSVVVLEEGRIHIRRLPLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF7</accession>
    <name>A0A7K0JNF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="339" mass="35547" checksum="9CE162C9C4E75002" modified="2021-04-07" version="1">MTEALRVIDFGTVPPLRSQTLWHAVAEGVGAGGPPTLSFVRTAAPYVSIGFHRSLDELDTDRCARAGWPVYRRVVGGGPVYLDSRQLCFQLSVPAAMVPAARPRALRYLLGPAVAAFRAAGLDAEIDGDGEIVVGDRKVCGHGAAQVGGAVVVVGNLIESFDHRAAASVLKAPDADDAAEALRLMRRYVAWDGGGPPVDATAFAGGAEESYGRTLGLPPRSGGLSVAERSALARLDRRMGSTSWNAARRSAPSPLWRLKVRSGVWLGSIRHSAGKIGVSVVGGRVERLRVWDVTVADPRQLDLETRGLGVGEAARHLRGRGAAGARAAAALVQMGDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH4</accession>
    <name>A0A7K0JNH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000088">
        <property type="protein sequence ID" value="MST31516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="11226" checksum="D4FCCD906FB69DB8" modified="2021-04-07" version="1">MDRDERTWLTVVPATRVASAADLAGWDLSALLAELTRVGRRVQRRYPAERIEVVAHGPRSRSGRHAHFHFTHAGAYCTADAVSGRLVSLPSRPAGGGARCNGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH8</accession>
    <name>A0A7K0JNH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="5" type="ORF">GHK86_02015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000086">
        <property type="protein sequence ID" value="MST31505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="19882" checksum="B964D8A01B91134B" modified="2021-04-07" version="1" fragment="single">MDNPRPEKVAVVDEVRARLDEADAAILTEYRGLKVKDLANLRRELRKDGGEYKVYKNTLVRFATRSRGLGELDEMLEGPTAITFVKGDPAAVAKTLRDYSRTNQLLVIKGGVLGDKVLDAAGTAALAELPSREVLLARFAGALAAPMQQLAGLLQALPRNLAYGLAALRDKRESEGGAPAAEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI1</accession>
    <name>A0A7K0JNI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000083">
        <property type="protein sequence ID" value="MST31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="235" mass="25740" checksum="485AB653E36BD214" modified="2021-04-07" version="1">MPEGKQQVGREAETRGRQPVATAGKGSSEGLPPVAQRLLALQRAAGNQAVVQHLLQRRFRPPEGGQRHNNSGGRGGTAEQLIYGATRVHRTSIPSFDIMDRHISVFPDRDGTARDFHVTFELLPNGGLAGRAHKARSDYEEAMEKEKAKEKTGAATSWRGGPRRPSAEGAVSVHFFYDEKGFLRSDFNQKLDKKLSERHGDEAYEILRGWANEIADDFIQGLEVVGAGKVAVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL5</accession>
    <name>A0A7K0JNL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar type III secretion system protein FliQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliQ</name>
        <name evidence="8" type="ORF">GHK86_02300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000096">
        <property type="protein sequence ID" value="MST31562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="91" mass="9699" checksum="217D4809338D0421" modified="2021-04-07" version="1">MNDTQVLNIAVQMLVEMGKLAAPVLIVSMAVGIGVSLLQSITQLQEATLSFVPKLAAVALVVVFAGHWMINSLVGFTDHMYRLIPALLHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS6</accession>
    <name>A0A7K0JNS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar biosynthetic protein FliR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_02305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000096">
        <property type="protein sequence ID" value="MST31563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="291" mass="30000" checksum="847FF434F23CE1F2" modified="2021-04-07" version="1">MGGRLRRALDDQLAGRLHRPHVPADPGAAARRLTLTVHVGSTLLLGFLLALVRTSAWVTTSPPFTTVGVPAYTKVGISAGLALAVVGHGAHSPLLAHLPTTTLGFMGAVLQQALTGLVLGFGTNLLFSTVGSAGALLDLATGLNLTAQLDPLSLQQTPVIGRLFNLVATMLLFASGGYLLLIEGLLESFRGVPLSLLRIGSIGALFTHQIAVMFLAALELAAPLLVVLFLSNVVLGLLTRAAPQLNVLSLSLGIQVMLGVLLVGVALPLLPGAVDNLLQQAVRGGLSLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW3</accession>
    <name>A0A7K0JNW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1028 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010430">
        <property type="entry name" value="DUF1028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06267">
        <property type="entry name" value="DUF1028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="24540" checksum="8071FBBF3B0FB174" modified="2021-04-07" version="1">MTLSVLGTDGAGAVGIAVASSSPAVAARCVHLRPLVGGALSQNVTDPRLGPLLLDALEEGLDPRQAVERTVRERPDIEHRQLAVLTMSGDGAAFSGAAALGVHAERVGRHVAAVGNLLASPCVVDAMVDAFERSADGEASRDGSALARPVGELEERLLSALLAGLTAGGEAGPVRSAGLAVVRRVPWPETDLRVDWADDPMGSLRDLLSVWLPQRDDYVLRALQPVAAPAYGVPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP25</accession>
    <name>A0A7K0JP25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7214" checksum="6E512DC74437BE4B" modified="2021-04-07" version="1">MAFVGDQLIGQVGHVTMRIAGAGRPGEVQLPIRGGSESFIAYGDEPIEAGAAVLVVGARPGRVVEVARLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP42</accession>
    <name>A0A7K0JP42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="11429" checksum="2D11FA21BF3FF8DE" modified="2021-04-07" version="1">MADARRQAEAAERAAVAEEVAALVRASGWSQRESAQRIGTSAPRLSTYLSGKVVPSAALMVRMRRVARRAEDRTGWQPGDATSGTDRSEPRGTPPTRRSPARPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP51</accession>
    <name>A0A7K0JP51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="17145" checksum="51D6111B860E7EAB" modified="2021-04-07" version="1">MGAAEIVVVVSGLLVAATALGGWAAWAGFRLGDRPDDARVDVAVATDRGPAVVCVTNLGLTPVVVGATLRWPRPLERIGGDPVLVRVPHRTPRAPLGPADHSLVGIVDAGQQGAWILPLPAGMARWPLVAVVTVGQRRDRSRIVVRRVSRVAAETAGACLARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP58</accession>
    <name>A0A7K0JP58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000128">
        <property type="protein sequence ID" value="MST31748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="1">
        <location>
            <begin position="24"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="679" mass="72989" checksum="3C21129425522082" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD3</accession>
    <name>A0A7K0JPD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000151">
        <property type="protein sequence ID" value="MST31832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="294" mass="32700" checksum="4C2CAEE7FDF0BE25" modified="2021-04-07" version="1">MGEIVGAGLVAHVPTIVLPEETRRELNEGKEISLVPGLERLRREVLDVLAPDTIVVFDTHWFTTVEFVVAAHDRRRGHYTSEELPRGMAAVPYDFPGDPELAKALAAEADEVDECWITAIDDPYLPVHYPTINLLPFLQGDERWVSVSVCQTAEPRDYLAVGACLGRAVEKLDRRVVLLASGAMSHTFWSLRELRKHEASDPVHLFTEEAAAADRRILDAWERGDHAAVVDGMPDYAAFKPEGRFGHYLMMVGAVGGRDCRAVGRPFSDYENSIGTAQIHVWFDRPDGGWTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG0</accession>
    <name>A0A7K0JPG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000138">
        <property type="protein sequence ID" value="MST31791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="25272" checksum="2A27EF6C4C31EFA8" modified="2021-04-07" version="1">QLAKTLVGAVSHDLRAPLTRIKASSSTLADADLQIDPEQARRLAALIDAQADRLAELVQNLLDMSRIQAGVLRPRYTVAPLADLVATVVDDLAADRRGYHVAVDVPDDLPPIDADLVLISRVLTNLLENALRYSPKDAPIAVRAVLDAPDRIEVSVADHGPGVSPHRRSAIFELFARRDADAGAGLGLTIAKTFVEAHGQRIWVDQAPGGGAVFRFTLPVAAAIPEESQVALHTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP4</accession>
    <name>A0A7K0JPP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_02135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029618282" evidence="2">
        <location>
            <begin position="30"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="111"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="416" mass="42512" checksum="8EDC6BB02DFED23D" modified="2021-04-07" version="1">MRAVVPALTLAALLAACGSTSSATGGSGAASSSGSGTSASSGATGSGSSGSSGSSGSSGSSGGMTPYQVAQARVAEFLKPPSSTLPVTSTLTVPKKKLTIAYTWCAQVVCASIAQGIQEAAKAIGANFVAEHHEDTASTVGTAFNNALAANPSMVLTSGDPEQWYASQAAQLKAKHVPLVAWSIPTGYESSPFSANLITNDDYYFQGVLEADYIAVQTHDAGKVLWEGVPQYPVLASESQGFNWEIKRVCPKCTVTSVDFSVQQLIAGDNVQATVTALQQHPGISWMAAAFGGLVTPQVANAVKAAGFGSLKAIEQAGTQSNFQMIAAHQLDAADIGLPTDYLGWLAVNDGLLALDGKAIPKFKPPAYTSIPGHPDVLVAGLPTQIITASDVPTGSAGFTPIPGFQSQFKKLWGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ4</accession>
    <name>A0A7K0JPQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000170">
        <property type="protein sequence ID" value="MST31903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="3">
        <location>
            <begin position="182"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="425" mass="46764" checksum="4F7C909D94713ACE" modified="2021-04-07" version="1">AAAVARLVEPLSAALSARGMSRLYDEVERPLVRVLARMEEIGVRVDVGALRALAEELSAEARRLEAEIQELAGTPFVVNSTPQLRQILFDKLGLTPQKRTKTGYSTDAQTLEKLRGEHPIVDALLRYREVEKLRSTYGESLLAEVAADGRIHATFNQTVARTGRLSSDQPNLHNIPIRTEEGRRFRACFVPADGCRFLVADYNQIELRVIAHLAEDPGLIEAFTTGADIHRTTAARIYGVDPADVTIAMRSKAKMVSYGLAYGMESYGLAQRLAIPVTEANQILEAYFVAFPNVRSYMDRVVAEARDRGYTETLFGRRRLIPELQSTRYQVRAAGERQAMNAGIQGLAADIFKVALVRLDERLEGLGLASRLVLQVHDEVILEVPPDEEAAAAEVVLEAMRGAADLSVPLEVNLSWGSTWAGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ6</accession>
    <name>A0A7K0JPQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000178">
        <property type="protein sequence ID" value="MST31938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="26552" checksum="013F56F1868885AE" modified="2021-04-07" version="1">MSGIGVWPSEATTGSLAEQAYFAVRDRLLTLAIPPGAPIQEDRLCAELGFGRTPVREALKRLEAEHLVVVYPRRGTFATEIDIADHALIADVRRHLEALAAERAAQHMTRADEAALRALRGDVDVAGGVARPGPGGDGGGAGPHRDELMRLDGRLHQALYRATHNPYLEATLGQYYNLALRLWYVFIDRLEDVADHVGGHAALLDAVLARDAATAGRLAAEHVERFERAVLAVELQAIPLTPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ31</accession>
    <name>A0A7K0JQ31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000203">
        <property type="protein sequence ID" value="MST32065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="375" mass="38174" checksum="02CB4489A02FCDCB" modified="2021-04-07" version="1">MRGRWAGASGAGPCSSGCTQAGRSGRSPTVATWCADACAERALSPGLPPRSSPRWGRGCGLPGDACGYVGPAGRAGGPARTIGAEKGLLPGSGRPSPSGSAADPPRRPVSTPTRVHPDPCPPPRRPALRPALPTTPEVPPMTVRADPPADGPGLLALVGGAEWQEGCDFDAELWERSGSGEVLVLPTAAAYEHPARTVEAARAWFGRLGAPVAGLMVLSRGDAEDPANAAAVRSARFVYLSGGSPLHLRSVLKGSPLWEALVAAWRDGAVVAGSSAGAMVLGDPMVDPRGGALTLGLGLLPGLAVMPHSDLWSEDKAHRTVQLATGDLRIVAVDERTALIREPDGTWRAAGAGGVAVYVEGRERGLDALASVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ53</accession>
    <name>A0A7K0JQ53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000117">
        <property type="protein sequence ID" value="MST31694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="32813" checksum="B4283E17D63E9D5E" modified="2021-04-07" version="1">MLRIGISIGTAFPTDGPGGHRAGPARVLAQARAAARAGLDTLTLGDHHATGPGGYVQNVPMLGRLTAEWVDRPLGCLFLVPLWHPVLLAEQVGTLAAMSSGPFIVQTGLGGGRDQFRAMGTDLRERADRLEEGIRVARALLQGEEVDSALYGLGAARIAPVPPEGTEWWVGGGVARAIDRAARLGDCWYGNADLTPATARELIAVYRDACARHDRRPVRIPIRKDVLVAEDQAAAERAGDALVAGGYRGFEREAVVYGDPDCVAEQLAVYGDLGYTDVIIRTMGPLPAELGPDAATRSVELAGEVRARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ83</accession>
    <name>A0A7K0JQ83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">clpS</name>
        <name evidence="3" type="ORF">GHK86_05165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="11055" checksum="1A3B31653322F72E" modified="2021-04-07" version="1">MPTAAPVEIRQPEVSEVVAADRPWKVIVWNDPINLMSYVTFVLQKLFGYSKDKAHKLMMDVHVKGKAVVSSGPQEKAELDVFRLHEHGLWATMEHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK2</accession>
    <name>A0A7K0JQK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="277" mass="30315" checksum="33F64E91A7995C14" modified="2021-04-07" version="1">MTVPAITLNNGVEIPQLGFGVFQIAPEDTVAAVSTALSVGYRHIDTAQMYGNEREVGEAVRQSGLPRHEVFVTSKLSNGRQERDDILRAVDGTVAALGGDPVDLFLIHWPLPTLRDYLVAWHALEEAHAGGKARAIGVSNFQVPHLERVLAESRTVPAVNQIELHPYLVQAELREFGHRHGIATEAWSPIARGKVLDDPAVGTIADRLGRTPAQVVLRWQVQLGNIVFPKSQTPSRIAENFSLWDFELGADDMATITALDRGERTGPDPDTFDRVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV6</accession>
    <name>A0A7K0JQV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="928" mass="97312" checksum="6E11717A0A48E65C" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ9</accession>
    <name>A0A7K0JQZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_06475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000279">
        <property type="protein sequence ID" value="MST32366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="149"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="37205" checksum="E99B08C1E930DB3F" modified="2021-04-07" version="1">MGELSDDGAFVRDTRYLDGRITADGRDGWPVEPGRYHLVVSRACPWANRAIIVRRLLGLEPVLSMGVAGPTHDQRSWTFDLDPGGLDPVLGIHWLADAYERAEPGYDRGVTVPAVVDIPSGAVVTANYPMITIGMETEWAAHHRPGAPDLYPEAWRDEIDEVAELVYRDVNNGVYAAGFAASQHAYEDAYHRLFARLDWLSDRLARRRYLVGDHVTEADVRLFTTLVRFDAVYHGHFKCNRQKLAEMPVLWAYARDLFQTPGFGDTIDFDHIKRHYYEVHTGINPSAIVPAGPDLSGWLAPHGREQLGGSPFGEGGTPPAPPLPAEAVPAGHSPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR29</accession>
    <name>A0A7K0JR29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000282">
        <property type="protein sequence ID" value="MST32385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8622" checksum="CB071B5CE4080464" modified="2021-04-07" version="1" fragment="single">MGTNSAWPLPALEDRTSQGLARAVTAAIADGRLPEGHRLPPVRTVAALTGLSPSTVSSAWGLLTRAGAIRTDGRRGDRGAPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR88</accession>
    <name>A0A7K0JR88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_06795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029807639" description="Methylamine utilization protein MauE" evidence="11">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="12">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="487" mass="50159" checksum="E00A24C3D144D34F" modified="2021-04-07" version="1">MTLVALVLRVAVGMVLLRAAMANLAGNVDLPSAVANYGLLPANLHRPVARTLPWAELVLSGALLVGILPRPTAAAGAAVLATFGAAMAVNLVRGRRFPCGCSSGDDEISWTHVADNCALAASAVLVAAEPRVTLSLYHPGQLSATGLSDGAAIALLLATGAAAALVALGVASMANLRAYHRTERGRTTMTAPWIAAFIVQWILVLGLAAVSLPTGSTSSTGSTSALAGRNVHARVMGAAKGASTSGSTVDLGRLTTQQTPTTAMASAATGPNVDRLCTSGSRIQQSPEIASRIGEIHVADVALAAETYVYHNAFTVTFTAGYSTTAGGTYSAGGSTSISHGESSTASTRWTAGYVRYVNSHFEYGKYLINQPGGCINPHYTDQVDVAIGDVFLGPNSPAQLGGECTSQPYYATLDGYPGQFNQDHSTAQQYTATSAFGFTFADTTGFSSDIHDDYTVGTTTQKGVDYVCGKGNVEPIHAKILYNTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA4</accession>
    <name>A0A7K0JRA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000306">
        <property type="protein sequence ID" value="MST32478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="285" mass="30741" checksum="C649BF5516F35F6F" modified="2021-04-07" version="1">MTETPRPAAEVRPAPPRTRDPIEAARVNDDAVAEFRAAHPEPMAPVVVVIPAYNEGASVAGVVATVPRELGGLPVDVLVVDDGSADDTSARAREAGALVLTLRSNTGQGNAFKAAYRIACEAGARYIATADADGQFDPKELDGLVRMIVEDRADFVTGSRRLGVAHTDDSVRALGVVVFGTLITVLTGVRITDPANGLRVMRAEVAANVDLRQLQYQSSELLINAIARGYRVCEAPVTMHKRKEGASKKGGNLVYGWRFTKVVFSTWWRLRPVARRSLSGRRGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC1</accession>
    <name>A0A7K0JRC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_06930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000297">
        <property type="protein sequence ID" value="MST32453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="244"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="340" mass="35277" checksum="C44D108CF7D7E85C" modified="2021-04-07" version="1">PFPSLPHATAARSGGALPTSLSTNWAGLAGTATAVQGAAGQWVVPKVAAVPASGYSATWVGVDGVGNTDLIQTGTEQDAGGAYFAWWEILPAPATVITQANGQPEPVRPGDRITASVQASTTTPGDWTITLQDLTRNWSFTQLEPYGGPGASAEWIEEAPTVNGVQSTPADFGTVHFAHTSVYTAGPTGTGWYATRLGRANEVALVNPAGTKVLALPSAPTPLSPPPGSPGQRFTVTYLTAPYPPADLHAARHGRAGVWLSWAPPRGTGGAPLSGYRVQLLHAGRVVRTLTTTLRTVKLPAAAVKGKGWSFRVQAVSIGNQTSHWTLPARLPAVHPTTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF3</accession>
    <name>A0A7K0JRF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="22075" checksum="234922D8BAF0B1B4" modified="2021-04-07" version="1" fragment="single">MSPRPYNLGRRQDQIAHGRRQILDAARALLGDTSGYAAFTIEAVARRADVARATVYYQFHTKTGLLEAVCDDLADLGGLDRLSAAFSAPDPADAIRHFVTAFGHFWAADRPAMRRLRALAALDPDVHHVITQRDQRRRDGLAVLTDRLQPDLQPSRRNRTINLLATLTSFETFDSLAGPDQPLTAATPDIIELALAAIPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN3</accession>
    <name>A0A7K0JRN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000340">
        <property type="protein sequence ID" value="MST32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="145" mass="14319" checksum="FFEA9769D192299D" modified="2021-04-07" version="1" fragment="single">MAAAEDGLAVDDGGEPDVVVLVAGAVVVELAGTAVVEVVVDAGVVVVELAGTVVVEGATVVLDGTDATVVVVEVPLLPEVWVLPTEPVLAWTALPGSLTGCSFSHSSMTALAIGAARVPPWSLTAIPWLGSITATAIVGWAAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS73</accession>
    <name>A0A7K0JS73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="191"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="356" mass="38637" checksum="87FE8F0F7C259FCD" modified="2021-04-07" version="1">MSKIRVAIAGVGNCASSLIQGVEYYREADPAEEVPGLMHVELGGYHVGDVDFVAAFDVDAAKVGLDLGKAIFAGQNNTIRFASVGDLGVQVQRGPTFDGLGKYYRETVEESPAEPVDVAAALRDSSADVLVAYLPVGSEQAQKHYAQACLDAGVAFVNAIPVFIASDPEWAQRFTDAGVPIVGDDIKSQVGATIVHRMLARLFEDRGMVLDRTYQLNVGGNMDFKNMLERERLQSKKISKTQSVTSQVERGIDAEDVHIGPSDHVSWLDDRKWAYIRLEGRNFGDVPLNVELKLEVWDSPNSAGVIIDALRCAKLAKDRGIGGPLLGPSAYFMKSPPVQYHDEAAHRMVEEFAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS91</accession>
    <name>A0A7K0JS91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_08735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000395">
        <property type="protein sequence ID" value="MST32805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="23747" checksum="51CE6F876CEF91E6" modified="2021-04-07" version="1" fragment="single">MPSPLRPLRRRNFALVWSAALVSNVGTWMQTVAVGVLVTARTGHPAWTALVAAAGFLPGGLLSPFGGVLADRHDRRRLFLVTTLGETACATSLAVLAAGGRATPGAVTLLVFAGGCASALGFPAYQAIMPDLVPRDELGAAISLSSAQFNLGRVVGPALAGIAIAAGGYAWAFGLNAGSFAAVIAALLLLRLPARVPDAGTGSVLARLAEGARATAADPSCRAAVAVISVTALTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB7</accession>
    <name>A0A7K0JSB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000397">
        <property type="protein sequence ID" value="MST32813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="8543" checksum="46838D4734646397" modified="2021-04-07" version="1">MAALVGCERQPDGAFTLRLATHDGSAPTDQGIADAVAAVAGRVRWVCLTRHEPLASAAFTRAAGCERRHGQYRRSPPPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC9</accession>
    <name>A0A7K0JSC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000407">
        <property type="protein sequence ID" value="MST32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="47"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="276" mass="29389" checksum="49CA47233CF2F87F" modified="2021-04-07" version="1" fragment="single">THRAADGVTVESFVLAPAGRGPHPAVLEIHGGPHGWHPQVVMLPLYQSLVAAGYAVVLPNPRGSHGYGEGFARACVGDWGGADFADLIGALDALTEAGVVDPGQLYVAGYSYGGFMTSWAVGHTGRFRAACVAAPVTDLFSMWGTTDIPNFAAFELGALPWEDPAVYAAHSPITALPAVRTPVLLLHWEGDLRCPISQAEQMFQGLRKLDREVALVRYPGGFHIQRTPSQMVDFVTRHLDWFGSHRGRPSRTAGEAAAGGRRSSGRRGSPASSGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK5</accession>
    <name>A0A7K0JSK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="3 9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">tig</name>
        <name evidence="13" type="ORF">GHK86_09315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 9"/>
    <dbReference type="EMBL" id="WJHE01000429">
        <property type="protein sequence ID" value="MST32915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="12">
        <location>
            <begin position="253"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="467" mass="50635" checksum="653E280E3CB14B16" modified="2021-04-07" version="1">MKTTVEPLEGNKVKLSIEVDEHEFERSIDAAFRKIAREVRIPGFRPGKAPRRVIEARFGAGAGRAEALRDALPDYYAQAVRDNDVDVIAPPEIDITAGEDTGPVVFDAVVEIRPQLNLVGYQGLRVTVPKPEVTDADVDAQVDRLRGNFGELVRVDRPARDGDNLTVDLGASRDGEAVAGLSSDDFLYELGSGTVLPELDTQLQGAKTGDIVAFDAELPDGTVSLRVLVKDVQEKVLPEPTDEWAAEASEFDTLEELRADLRRRLESVRKVEAMYAWRNGTVEALIELVEAEPPEPLVQAELERRAHDFAHRLESQGVSIVQYLQATGQDEGQVVAGLRAEAVPAVKADLALRAVAEAEGLEPTDEELEAEIGRLAAAYGQRPDQLRANLERAGQMPAVRSDLKKSKALEWLGEHVELVDPDGQPVDRTLLAPEPPSEPETTSEASTDDTGGATETDPTAAPESGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK7</accession>
    <name>A0A7K0JSK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000432">
        <property type="protein sequence ID" value="MST32920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="20514" checksum="95B4D62D71518FCE" modified="2021-04-07" version="1">MSLSGTAAYRGQGDLPPLVAEAVRLAERLGFAHSCTPEQGRLLQLLAAGRPGGVVGETGTGCGVGVAWLLSGAARGTRVVSVEREPERAAAAAALFAGVPDVTIRCADWSAILADGPFDLLVLDGGGAGKGGERPVDPVVALRPQGAIVIDDFTPADRWPPQHAGAPDAARLHWLEHPSLAATELRLTPTLATVVGVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM8</accession>
    <name>A0A7K0JSM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate synthase large subunit</fullName>
            <ecNumber evidence="17">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">gltB</name>
        <name evidence="17" type="ORF">GHK86_09530</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="17"/>
    <dbReference type="EMBL" id="WJHE01000442">
        <property type="protein sequence ID" value="MST32956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MST32956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1366" mass="147416" checksum="06BF60DC14114EAA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV0</accession>
    <name>A0A7K0JSV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000336">
        <property type="protein sequence ID" value="MST32589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="542" mass="57762" checksum="D7C09DED45621961" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV3</accession>
    <name>A0A7K0JSV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000451">
        <property type="protein sequence ID" value="MST33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="92"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="35964" checksum="06550F2A276A7557" modified="2021-04-07" version="1">MTVLEVAEPVSPLVGAPPSSPAHRLRRAVRPLAGYLLVLPALGVLIVFYYVPALLLFVISFFHYHLGGAGSSFAGFDNFRVLFAQPLFWQSLVVTGYYVLVMVPATLVASLALAMLLRDGIRRSRRRKGGAAQALIFLPHVTPLVATSLVWVYIFDPQYGVANDVLRAFTSHPPNWLFSTHYAMPAIEIYSLWHSLGFYMVLFLAGLSNIPDRLVEAARVEGVRGFAAFRRVIFPLLTPTVYLVTVLATVNTMQAFSQIYTLSGGAHGHGGGPAYSTTTDALLIYQTAFTYNHFSLASAMSLILFAILLLLTLVQRWGFSKLVFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT19</accession>
    <name>A0A7K0JT19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000474">
        <property type="protein sequence ID" value="MST33080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17960" checksum="CABC33A6C4D9A9B8" modified="2021-04-07" version="1">MADNSAALRRARREDARIKRQRAYEAITALETSGQPVTFPAVAARASVSVSLLYSDQDLAGRIAAARDRQRQAGADRAWQLPARSLITEHSLRVELTNAKDQARRLTEEINLLRGRLSRHSGHKPTPPGGKPSLLPSTSSRPASRAGSRQPPPTTAHRPAPSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT33</accession>
    <name>A0A7K0JT33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000359">
        <property type="protein sequence ID" value="MST32679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8743" checksum="028BAADFFCAE8E1B" modified="2021-04-07" version="1">MTHPLFGRVLAATGFKRWKGRLLLVVVLPDGAPGTIAVEATDVFGGAELVVSPAVFSVEGLRALRLMAETLGARSPTGRGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT36</accession>
    <name>A0A7K0JT36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000489">
        <property type="protein sequence ID" value="MST33111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029567345" evidence="1">
        <location>
            <begin position="37"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="34923" checksum="76445335E6016F56" modified="2021-04-07" version="1">MTAVGRRSRARRHGPLGALVCSIALALVLSACGVSATGQTAASRPTQPAGPPVTLPAVNAPKDSFAFDYGQLRLWLPTHWTAENETGCLTPLHDVVLLADACPHAGSHGTYLRLSPRATPAAGATKLTVGHTTVYQTTTAGPGIRWSVPSLQVTIQIVGAVARSVARTLGPSSLHALLALHHPVAVPAAWKTVRYDGIHARVPAHWQVVHQLFWLTCHGFLNPGRRPPLVLLGDQDQDPSSSCPSGFDPTTQLRPTNGLWLSSSNAPFLPGGAGTITATTHLDGRTLTLRSTPSDGPLLEVIVRHGPRRTVAVIALGTNPTTAEAILTSVQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT45</accession>
    <name>A0A7K0JT45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ORF">GHK86_10370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="WJHE01000491">
        <property type="protein sequence ID" value="MST33121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="247"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="313" mass="33724" checksum="D77C4FDD604BFE84" modified="2021-04-07" version="1">MLIIQRPTVEPLGEQEGDRQRFAIGPLEPGFGHTIGVALRRTLLSSIPGAAVTQVRFDDALHEFTTLPGVKEDVTDIILNLKDLVLRVESDEPVTLRLDVRGPATVTAGDIATTSDVEVLNTDLVIATVNAKGRLAADITVERGRGYVSADRNKKSSTIGVIPVDSIYSPIRLVAFSVEPTRVEQSTNYDRLVMDITTDGSMTPREALASAGDTLRSLMGLVAEMSDAPQGLELGDVGAATSGSPDLDLPIEDLDLSERPRNCLKRAQVNTVGELVQKTEDDLLAITNFAQKSLDEVLQKLDERGLALRGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT50</accession>
    <name>A0A7K0JT50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_10225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000481">
        <property type="protein sequence ID" value="MST33093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="249"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="482" mass="50657" checksum="F230DC617848C0AE" modified="2021-04-07" version="1">MASVETRGRRSPSHRVRRATPRSSRRARHRRGLGAPARYLVTATASSSLGDGLALVAFPLLALRYTHNPLLVAGVAFADTIPALLFGLPAGVLADRWPRRMMARAAEWIRLGVLAAFVALIVLGLDSLWSLYATVFLIASFEQVYKAAAFSSLPAIVPSDLLGRANSRLWVADTSGEQFIGQGLGGLALGASRALPFAVDAVSFAASAILVGRALPPEAPAEPDEAGRKERNLRAELAEGLRWFASHPVLRLLAALIGSFALCQFIVAAIVVLYARRVLHLSNAEYGLLMAVAAVGSVLGSLAADRVSGRLGAIPSTVLGGVLTAGAYLGLAAWRSPVGLVVFLMLESLAVPVASVASLTLRQRLIPSELLGRVGMVFRLFLYGAMPLGALIGGLLAAHLPYREVFLVAGGLQLTLLLALSSRLIPRARADQQIIDLEGRSGRQTDASGDAAVIELDPVIDLGAEDEAAVRSGGRATSPGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB5</accession>
    <name>A0A7K0JTB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000511">
        <property type="protein sequence ID" value="MST33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="477" mass="50562" checksum="C29F01D921EEF920" modified="2021-04-07" version="1" fragment="single">MPEGLGYRLKNRLLGPPLTSEQLHEQKLGKVAALGVLSPDCISSTAYGSEEMLRILIPAVGVAAFSLLLPVTAAVIVVLFFVTLSYREIVMVYTKTGGSYMVSRENFGPRVAQVAAAALIIDYSVTVAVQVAAGTAAVTSALPGLLPASVEISVAVVLLMAYGNLRGLREASKVFALPTYLFILCMGGMVVVGLVRAALGDLHAHSIHVQGAVSIGHAPDVGLLMGASVFVMLKSFANGGSSLTGLEAISNGVSAFRPPSGRNARRTLVVMSVTLGTLVVGVSLLARITHAVPYLAGSPTVVAQEAEYVFGHGALGRALYLLVIVSNVAILYTGGNTSFNGFPFLTSFVAHDSFLPRWLTRRGHRLAFSNGIIVLTVIGVALLVASNSNVDSLVAVYAIGVFTGFTMAGAGMVRYHRRHRLPGWRKRQVINGFASLLSGAVVIIFAVTKFTQGAWLVVILFPVLVYALIRINRRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC3</accession>
    <name>A0A7K0JTC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxidase-related enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000503">
        <property type="protein sequence ID" value="MST33163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010195">
        <property type="entry name" value="Uncharacterised_peroxidase-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01926">
        <property type="entry name" value="peroxid_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="21231" checksum="1C29EF1D10075E3F" modified="2021-04-07" version="1">MAAVFPAPDPDTLPDDLQARIAEVGERSGFVPNIFLTLARRPAEWRAFFAYHDALMDKETPALSKADRELIVVATSAENHCLYCVVAHGAIARIRARNPRIADQVATDWRKAELDPRQRAVLEVAVRLAVEPWTVGQDALESLRAHGLTDEDIWDVGAITAFFAMSNRLVHLTGTMPNDEFYLLGRVPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI0</accession>
    <name>A0A7K0JTI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="1">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="1">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">sucD</name>
        <name evidence="4" type="ORF">GHK86_10885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000526">
        <property type="protein sequence ID" value="MST33223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1 2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="294" mass="29748" checksum="6BFF6AF3E936F080" modified="2021-04-07" version="1">MSIFVDDNTKVLVQGLTGGQGRFHGLRNKAYGTKVVAGVTPGKGGQDVEGIPVYDTVAEAVAATGADASFVSVPPRFAAEAILEAARAGIPLVVCITEGIPAHDEARVFATLRAEHPGTRLLGPNCPGIISPGKTNIGITAGEIALPGGPVGIVSRSGTLTYQALYELKQLGIGVTTCVGIGGDPVPGTNFVDCLAAFEADPDTGAIAMFGEIGGIEEERAAEFIAKEVTKPVVAYIAGVTAPPGKKMGHAGAIISGSKGTAQAKMEALAAAGVHVVNNPTEAGQKMAEIVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK6</accession>
    <name>A0A7K0JTK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000541">
        <property type="protein sequence ID" value="MST33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="21844" checksum="E082E2B4A961F4C5" modified="2021-04-07" version="1">MSTFQIQDGPDAEAMIRRVIDIIESTRTLPLSSSVKLDNREEVLELLEDALARLPQDLRQARWMLKEREEYLGKMQREGEDILQAARQRAERMVQRTEIVREANHTARDIIEAARDEARRLRLESEDYADQKLAAFEIVLERTLKTVAAGRQKLAATPVAPASERSNGTVAGAGSTDDTIVATEAFFDQDQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL4</accession>
    <name>A0A7K0JTL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000546">
        <property type="protein sequence ID" value="MST33286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="24475" checksum="CEF2BEA07AD0246B" modified="2021-04-07" version="1">ANRGAQETSRPLVLVCNPDLIVDAGAVEALVARLAADPGLGLVGPLVRNPDGSVYPSARTFPDLVDALGHGALGLLAPGNRFTARYRMLDWDHARPARVDWVSGACILARRTAWSDIGGFDPAYFMYLEDVDLCWRAGEAGWAVGYEPGATVTHVQGVSAGRHPYRMLLAHHRSLWRFARQTTAGARRLVLPVVAVGLVGRFAVAVAAHRLSPGSARQAIHRPVAGPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN2</accession>
    <name>A0A7K0JTN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000441">
        <property type="protein sequence ID" value="MST32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="17575" checksum="4FBCE9F02B38101A" modified="2021-04-07" version="1">MAFNLQTVDPLIATNFFLTIGSDVVVNITSVDGLTLEIETADINQRTAKGVLVQHKTMSKPKWTGELNVKRLAPLDASSDELWKWFMSIRTTGMAAASRATQRKSGGISIYDASMTLVASWTFTEAWPSKIETEGLDVTKNDPVSETITLQYETLTRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP4</accession>
    <name>A0A7K0JTP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="12211" checksum="F55A8F2769E8016C" modified="2021-04-07" version="1">MTARRGDIWLVDFGEPIGRGQAGRRPAVVVSADPLNDSRAGVVIVVPCTTTWRQLPSHVELDPEVCGLDEVSYAKCEDVKSVSDERLVTRLGAANDEALFAITRALRFLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX2</accession>
    <name>A0A7K0JTX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_11790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000580">
        <property type="protein sequence ID" value="MST33396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="PTHR42825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="13985" checksum="9265531299867342" modified="2021-04-07" version="1">VEELGGMNLFFVERDGADVTLVTPPLTGTLLPGIVRDSLLTLAPSLGYQAVERVVTVEDWEEGCRSGRWTETFACGTAAVVTPVGEVRHRGGSWTVGDGAAGEVTLAVRGALLELQTGRAADPHGWMHRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY3</accession>
    <name>A0A7K0JTY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000578">
        <property type="protein sequence ID" value="MST33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="46" mass="4824" checksum="D51D4C337CECAB64" modified="2021-04-07" version="1">MVQTLRRALVAMGAAGVVALVVRLRGSGGTPPRHGGWRELPASELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC5</accession>
    <name>A0A7K0JUC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_12595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the trimethylamine methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000636">
        <property type="protein sequence ID" value="MST33555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038601">
        <property type="entry name" value="MttB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010426">
        <property type="entry name" value="MTTB_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06253">
        <property type="entry name" value="MTTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037567">
        <property type="entry name" value="MTTB_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="479" mass="52634" checksum="24B47E96E7391AE7" modified="2021-04-07" version="1">MFVNRMPRYEILSPDAIEVLDRGWRRIVSEIGVQFVKPEAVELFAAAGQRTDGETVFLDPEFVLEQVAKAPREFDLQARNPANNVHIGGDHMVFSGVYGPPFVREGAVRRDATMTDFRRFSMLAQSFPELDSAGGVICEPNDAPLDSRHLDMIFALQTLTDKIYMGNVVSGANARDTIAMTEILFGSREAIEATPATVSLINCNSPLRWDDRMLDAQFEYNRANQPVVLTPFLLMGAMSPVSIPATLAQQLAEALAGIALSQLVREGCPVIFGSFLSNIDMQSGSPCFGTPESAIGLLCTGQIARHFGLPFRSGGGLTSSQVADAQAGYEALMTLLPTFLAGTNFVMHAAGWLEGGLVSGYEKFIVDVELLRMLREEFTPLEIDEASLAFGAHEEVGHGGHFLGAAHTMERFRTCFYRPLLSNSQNFERWNREGGKDANIRAGEIAQRTLDAYEPPPLDSAVRAELEDYVSRRRKELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE3</accession>
    <name>A0A7K0JUE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF294 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000631">
        <property type="protein sequence ID" value="MST33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF294" evidence="2">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="7777" checksum="DB66696D93D8741E" modified="2021-04-07" version="1" fragment="single">MDLRERRSVLLARDGLRGRELASALAAATDAWLREVFDAACGPAACDVALVAVGGYGRGELAPGSDLDLVLVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ4</accession>
    <name>A0A7K0JUJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_12940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="199"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="321" mass="35361" checksum="0FF32F4BDFE4E9CB" modified="2021-04-07" version="1">MATELEPFRRELTGYCYRMLGSGFEAEDAVQETLIRACRAVDGFEGRSSLRSWLYRIATNVCIDMSRQVQRRARPAQLAPASPPDVSRLGPMLPEATWVTPIADAQVGLEFDDPAELAVQRDSVRLAFVTALQHLPSRQRAALILCEVLHWSAADTAELLDTSTAAVNSALQRARATLAALPDGGRPRPLDTEQADLLDRYVEAFERYDIEALVALLHDDAVQSMPPFELWLQGAGDIAAWMVQPGPDECRGSRLVTTSANGCPAFAQYRPDPAGGWTPWAIQVLEVSGGRIAEMAFFLHFLDPDRLFASFGLPLHLDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK2</accession>
    <name>A0A7K0JUK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="7">2.9.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">selA</name>
        <name evidence="7" type="ORF">GHK86_13025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000668">
        <property type="protein sequence ID" value="MST33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0711">Selenium</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Se-cys_synth_N" evidence="6">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="385" mass="38772" checksum="21A60A2C2793544E" modified="2021-04-07" version="1" fragment="single">MTATVPSHDPRRSVPSTTVLLGEPAIAGALGRWARPVVLDAIRGAQEAVRSGASDAAGIIDEVLARLPLRPTSLRPVLNATGVVVHTNLGRAPLSPTAREAVALAAGYTDVEFDVAAGTRRRRGAGALDLLAAALPDAGAVHVVNNGAAALLLAVTGLAAGREVVWSRGELVEIGDGFRLPDLAVATGARLREVGTTNRTFLEDYRAAVGAGTGCILKVHPSNFRVEGFTSSVSVAELARLGPPVVVDVGSGLLAPDPLLPDEPDIAGALRAGAAVVTASGDKLLGGPQLGILAGRVEVVDALRRHPLARALRVGKLTLAALEGTLLGAATPVADALRADPAILADRCRRLADRVGGQVVPSDGAVGGGGGPGVALAGWAVAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT4</accession>
    <name>A0A7K0JUT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000692">
        <property type="protein sequence ID" value="MST33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029629281" evidence="2">
        <location>
            <begin position="36"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="297" mass="30891" checksum="493361DB58BCFCDC" modified="2021-04-07" version="1">RRRLGLPLAVTAATAGMVAAMLLPVRPAVPTGARAWTRTIVVGGRRRHELVVAPRHDAVGLPLYVVLHGSDATPAFEERRTGLSYLAGEGRAVLVYPAGFAESWNAGQGCCGDAGATHSDDVAFIEAVVADAVDHLGVDPRRVFLVGYSNGGKMALRMLSVDPAAFAGVAVYAATPLVPVEHGPPVPVLIAGGTADPRTPWSGPPQVQNGALAPSVVGAADILRRRDRTGAGAEVTTSAGGRVRVTTWQGPSRREVVRLVAYRGRGHAWPQAHDAPLPLAPLVVAFFDQVSASPDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV38</accession>
    <name>A0A7K0JV38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-phosphoglucomutase family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000732">
        <property type="protein sequence ID" value="MST33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26048" checksum="24471D4C0F9F4AEA" modified="2021-04-07" version="1">MLGLPDGITACLFDLDGVLTDTASVHAAAWKDTFDEYLERRSQREAEPFRPFDRHDDYDDHVDGKPRADGVRDFLASRGITLPEGDPADPPGAETIHGLGNRKNERLQARIRRDGVTVFDGSRRYLEAVRAAGLRTAVVSSSANTAEVLQVTGLAPLLDARVDGVVAAEQHLAGKPAPDTFLEGARRLGVQPPAAAVFEDALAGVAAGRSGGFGAVIGVDRVGQHDALAEHGATRVVGDLAELLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV52</accession>
    <name>A0A7K0JV52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_14075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000742">
        <property type="protein sequence ID" value="MST33840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="332"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="531"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112280" checksum="C8FBECB9E3F16ADA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE0</accession>
    <name>A0A7K0JVE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000626">
        <property type="protein sequence ID" value="MST33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="13681" checksum="60FCCD20B1CA20C9" modified="2021-04-07" version="1" fragment="single">MRIVDAANHDRADAGGIKVGGHQASSASMVGIMTSLWFDLLGREDKVAVKPHASPVYHAIKYLTGEIDRSWLPRLRAFGGLQAYPSRTKDPDVADFSTGSVGHGAVAPLFAAATRRYLQGRFELGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG5</accession>
    <name>A0A7K0JVG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_14570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000780">
        <property type="protein sequence ID" value="MST33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="108"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="19695" checksum="EFDCE11C05E12DAF" modified="2021-04-07" version="1">LARIPPTRPDVALLDVRLGDDPDGPSGIEVCRDIRSAHPEIACVMLTSFADDEALFASIMAGASGYLLKQVRGQDLVGALRRVAAGESLLDPAVTARVLERLRQPAPATDPLSDLSPQERRILELIADGLTNRQIAAEMYLAEKTVKNYVSRLLAKLGMSRRSEAAAYAARLEERSRHGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG8</accession>
    <name>A0A7K0JVG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_14610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="WJHE01000784">
        <property type="protein sequence ID" value="MST33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="423"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="463" mass="49882" checksum="48B5F5905AF1E07F" modified="2021-04-07" version="1">MFPPGFVWGAATASYQIEGATRADGRSPSIWDTFSHTPGRTHNGDNGDVACDHYRRLDEDLDLLAALGVGSYRFSVAWPRVQPDGKGPANPAGLDFYRRLVGGLRDRGIAPTATLYHWDLPQALEDAGGWVARDTAERFAEYAAVVGEALGDGVERWITVNEPWCSSFHGYGNGLHAPGRTDTGAAVAAVHHLLLGHGQALAALRAGGARSVGITLNLVPVRPASGHEADAAAARRMDGYANRMFLDPLLRGRYPSDMAAAFSSARPGLGVVQPGDLEVIGQPLDFLGVNYYSPAIVADPSRLDEARRAGLVPSERQAERVAAELGVARVVRAGSDRTAMDWEIEPSGLTDLLVGLARDYPVPPVYVTENGAAFCDYVDPDGRVQDPARVEYLDGHLRAVAQAIGEGVEVRGYFCWSLLDNFEWAYGFAKRFGLVWVDYATGARIPKSSFSWYRDVIAANGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM2</accession>
    <name>A0A7K0JVM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000796">
        <property type="protein sequence ID" value="MST33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="527" mass="54375" checksum="8A101E21E852EC87" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM8</accession>
    <name>A0A7K0JVM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ClpX-type ZB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000807">
        <property type="protein sequence ID" value="MST34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="8867" checksum="C523F8334CB83D88" modified="2021-04-07" version="1" fragment="single">MDDHDDGDLFQCSFCGQAPSGPDTLIAGPHGVFICGGCVLVCGAIVEQGRGAPGEPPDHLEQALRPRAPGGPAGAGRQEAGGDRTGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT8</accession>
    <name>A0A7K0JVT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000835">
        <property type="protein sequence ID" value="MST34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="7210" checksum="9BFA3679C55D6F49" modified="2021-04-07" version="1">MKKGRHRRFEEARALKRSNEEMNEPCPECGARPGSEHASWCLAMEDEEEEYEPAAPDHPAPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW15</accession>
    <name>A0A7K0JW15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000872">
        <property type="protein sequence ID" value="MST34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="91" mass="9805" checksum="9E53229C5456C70C" modified="2021-04-07" version="1" fragment="single">MDIVATYEQVGTYRATAALCGTTHKTVRRVVEAARAGEPPDRRRRPARPAVTAGVEDLIAQRVRGTDGRITAKRLLAEVRAAGYTGSARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW48</accession>
    <name>A0A7K0JW48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_15735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000881">
        <property type="protein sequence ID" value="MST34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="423" mass="47243" checksum="1F2C89CA739FEF3A" modified="2021-04-07" version="1">MTDSITVTDNRTGEAVEIPIVDGGVSADELRKLIPGIWISDPSFMTTALASSAITYLDGEGGVLRYRGYPIEQLAERSSYLEVAYLLVHGELPDAAQLQTWTDEIRMHTYLHDNFRKRFLDGFHYDAHPMGMLVSGMAALSTFYPEAKDVTDPAVRRRQIIRMIAKVPTLAAACHRYSVGMPFVYPDNSLSFTENFLSMMWKVAEPRYEPDPVLARALDVLFILHADHEQNCGTLAMRTVGSAHADPYIAASAAAAALSGPLHGGANEQVLRMLASIGHVDNVPAFIADVKAGKGKLMGFGHRVYKNYDPRAKIVKQTADAVFEVTGRNPLLDIALKLEEVALSDEYFISRKLYPNVDFYSGLIYQAMGFPTEMFTVLFAIPRVAGWVTHWQELLEQDAKIYRPRQLYVGRESRDYVPLEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW61</accession>
    <name>A0A7K0JW61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000889">
        <property type="protein sequence ID" value="MST34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="231"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="36472" checksum="2E964672094CEE00" modified="2021-04-07" version="1">MTPTDIVAAEGSARTRRIPRHVVLIAVDGVQALDLTGPCDVFGLADPDGDRYRLTVVADQPMVRCSSGLRITPDADLAAAPGDIDTLIVPGASRDRGLNVDEHVITWIREAGGRARRVASVCTGAFLLAQAGLLHGRRATTHWAATDELASSYPDIEVLADPIYVRDGNVYTSAGVTAGIDLALALVEEDLGPAAAQRVARALVLFIRRPGGQAQFSHALRLPPAQRANIRELQDWIIDHIDHDLSVGALAKRSFMSQRHFARVFSAETGMTPAAYVEATRLERARLLLESTNEQLDVIATRCGFGTPETLRRSFARHLHVSPAAYREHFGSGTPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW64</accession>
    <name>A0A7K0JW64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000894">
        <property type="protein sequence ID" value="MST34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="35754" checksum="A86F161527CC103D" modified="2021-04-07" version="1" fragment="single">MRWPILRKPTGSAAAGQNRWRLRRRSATLVAVDTWTPGSWRSRPAAQQPDWPDAHALDQALKELSALPPLVFAGEAASLRRALAQVARGEAFLLQAGDCAESFADFGADTIRDKLKVILQMAVVLTYAGGVPVVKVGRIAGQFAKPRSSPTEVVDGVELPAFRGHIVNDDAPSPQARIPDPDRLVRAYHQSASTLNLLRAFTKGGFADLSQVHVWNQEFVASSPGGRHYAAVADEIERALRFMRACGINLGDEQDLHQVDFWTSHEALILGYEEALTRRDSLSGDWYDCSAHLLWVGERTRQLDGAHLEFLSGIANPVGAKVGPAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW78</accession>
    <name>A0A7K0JW78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">GHK86_15915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000894">
        <property type="protein sequence ID" value="MST34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21219" checksum="FBB410C6D8944E79" modified="2021-04-07" version="1">MGQRIGIFGGTFDPIHVGHLVAAVNAKHALALDRVVLVVANVPWQKAGIRAVTGAEDRFALVEAAVGGVPGLEAGRQEIDRGGESYTADTLQEMSDAHPDSELFVLVGWDVAGELATWERIEDVKRLATLVIVNRPGAGRPRGLDGDGWRVEEVTVPNLEISSTDLRARAVDGRPLDYLVPEAAVHFIRARGLYAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW82</accession>
    <name>A0A7K0JW82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000891">
        <property type="protein sequence ID" value="MST34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="20730" checksum="09300B27298F169E" modified="2021-04-07" version="1">MTTLMDRPHTALLVIDVQNDVVANAHDRDGVIANIRTLVERARAEGAPVVWVQHADDDLTRGSDGWQYVPELVRGDAEPLIHKSYGDSFEETDLAEVLAERGVGRLIVTGAQTDACIRATLHGALVRGYDAVLVADAHTTEDQSAYGAPPPEQVIAHTNLYWAWERAPGRRGGTARTAEVGFGPGTSRPDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE5</accession>
    <name>A0A7K0JWE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_14220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000754">
        <property type="protein sequence ID" value="MST33869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="35040" checksum="3370E8DBD4F3AFBB" modified="2021-04-07" version="1" fragment="single">MRAVVMAGGEGSRLRPLTSTQPKPMLPIGNRPLLEHVVDLLGRSGLTDITLTVGARAEAIRTYFGDGADHGVRLGYAAEDVPLGTAGSVRQAMAGSDEACVVLSGDVLTDIDLDALVAFHQSHEAEVTVAVQRRDDPLDFGVVVTGPDGGVDRFLEKPTRGRVLSDTVNTGIYVIEPSVWESVPAGRAVDFAGEVLPGLLEQGRTVCASVAEGYWEDVGTLHAYLRAHRDLLDGRVRARIDGFQIADGVWLGEGAELHPTAVVTGPAIIGARTRVDAGAEIGAYCSVGPDAQVGPEASLERSVVHAHAYLGRRAHVRGGVVGRTARVRAGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE7</accession>
    <name>A0A7K0JWE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000921">
        <property type="protein sequence ID" value="MST34268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="56" mass="5750" checksum="95ECBFF1136CBF22" modified="2021-04-07" version="1">MMAAVAGAVLIAIVLVVVLPAAFWFVWGAVAWALGQLLTGEAEATHEGSELIATNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF8</accession>
    <name>A0A7K0JWF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000759">
        <property type="protein sequence ID" value="MST33879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="18672" checksum="9BD16FBA1E9AB58F" modified="2021-04-07" version="1">MPHQAGGMTGPAAGLVEVQVLGLPLDIWARTQEHMDGLLREFTLLVAGDATSTTRHAPRRLLDLVAELEADYAGMTSDQEQQLAEAADAGKDAIDLTYLVPTSVREACRRLDEALDEADRYCLEGEYLLTLATPADARAFRRWFLVQFMEQIDGRPARSWPEWQAADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK2</accession>
    <name>A0A7K0JWK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000946">
        <property type="protein sequence ID" value="MST34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="32761" checksum="0642FD145F466BEA" modified="2021-04-07" version="1" fragment="single">MSAPDDRSALEALRGRCTRFLNGHGHRRPAELLAAIPGDTEADRYGEGGAVADLEAEVAALMGKPAAVFVPTGTMAQQATLRVHADRRGRRSVVWHPACHLDWREGRGYQRLHGLVGTPAGEMRTPLTPAALAAVAEPPAALLLELPQRDLGGVLPAWDELETMTAWARERGAAAHLDGARLWEAAAGYGRSEAEIAALFDTVYVSLYKGIGAIAGCCVAGPADVVAEVSEWRTRHGGRAFALWPYAASGLAELARRRPRMPGYLAHARAVAAAVAEVDGVTVLPSPPQTSMMHLQLGATPSDLRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL3</accession>
    <name>A0A7K0JWL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000951">
        <property type="protein sequence ID" value="MST34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="365"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="457" mass="48577" checksum="EBBEE426B1DDA20A" modified="2021-04-07" version="1">MYEIINIDTPTLGDRSYLVHDGSTAFVIDPQRDIDRVLDLAAERGVRIAHIFETHIHNDYVTGGLALSQVTGAAYHVNRDDPVAFERVAVTDGDLIEVTPSLRVRAIATPGHTFTHLSYALAVEEDVVAVFTGGSLLFGSTGRPDLLGPESTDALARHQHASAHRLATELPEAAGVFPTHGFGSFCSATQAEGTASTIGAERSSNPALRMSEDDYVEALVVGLDVWPAYYAHMGPANTSGPGAPDLSPPALADAAELRRRIDAGEWVVDLRNRTAYASGHVAGSLNFGLDGSFATYLGWMIPWGTPITLLGETPEAVAEAQRELVRIGIDRPAAGATGGPGDWSGGEALHTYRRATFADLAGVAGREGVVVVDVRRRLEWEEDHLAGAIHLPLHELVARVDEVPEGEVWVHCRSGYRASLAASVLARAGREVVVVDDELTNADGAGLDVVRGAEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN3</accession>
    <name>A0A7K0JWN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pdxH</name>
        <name evidence="9" type="ORF">GHK86_16430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000936">
        <property type="protein sequence ID" value="MST34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="7">
        <location>
            <begin position="30"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="8">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="204" mass="22567" checksum="35EE3BAA922DDBFE" modified="2021-04-07" version="1">MGEHSRSLDAADVVDDPLEQFRRWYTEAESAGVAEPEAMALSTATADGAPDVRFVLLKAVDDRGWVFYTNEHSAKGTQLAANPRAALAWRWAALDRQVRVAGTVERVAAELADAYFASRARGSQIGAWASEQSSVLPGRSTLEARVADAEARFAGEAVPRPSWWGGFRVVPDRVEFWQGRPSRLHDRVRYRRDGAGWSLERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ2</accession>
    <name>A0A7K0JWQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ORF">GHK86_16815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000973">
        <property type="protein sequence ID" value="MST34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="36"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="19315" checksum="F7B5C129673B8385" modified="2021-04-07" version="1">MGLENLQHNFLTGTLEGMVKWARVSSSWAANFGLACCAIEMMAAGAANYDLARFGMEVFRASPRQADVMIVAGRVSQKMAPVLRQVYDQMMEPKWVISMGVCASTGGMFNNYALVQGVDQVVPVDVYAPGCPPGPETLIHAILTLHQKIRLGELTRRDGEGAGIRLAEPPQPLRLGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT6</accession>
    <name>A0A7K0JWT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000992">
        <property type="protein sequence ID" value="MST34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="9480" checksum="32A3DA9C82021EC6" modified="2021-04-07" version="1" fragment="single">MSAWSFYISTLVVYFGVDLLSGVALNLQYGYAGVVNLAFIVFQAFGAYIAAATTLGPDTGAGAFQKYIFGAHLPFPLPLVLATLGGAALAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU8</accession>
    <name>A0A7K0JWU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000819">
        <property type="protein sequence ID" value="MST34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="6344" checksum="BF030C6DA2E7FDE6" modified="2021-04-07" version="1">MLAAQLADGIAAADAVREGLAEGLVLNAVAPGALRLAPPLTISDDEIDEGARRLGAALARLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ6</accession>
    <name>A0A7K0JWZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001022">
        <property type="protein sequence ID" value="MST34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="16109" checksum="225CB1E15F06B5A3" modified="2021-04-07" version="1" fragment="single">MSLFSGAAAYTRLLRLPDARRIVVASCICRLSYGMLSLALLLVVEHATGSFAAAGTAGAAFSLAALTAPAKARFIGSRPRRWGIGGLGAAYGASLLALVALGIRQVGAPLPFVALSATAGLATVPIGPMMRARWARVAAPEERRRAYALDVALEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX39</accession>
    <name>A0A7K0JX39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_17540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001048">
        <property type="protein sequence ID" value="MST34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="31057" checksum="63DF752254030CAD" modified="2021-04-07" version="1">MYESTFARWFRRISLGLIALFAVFPLFVILETTVKPLRDVQNTWQWVPSHITFAPYAQIWTTIPLFHYFINSVIVSTISTVVAVTLAVFAGYAISRFEFRGRRLFSLAVLSTQMFPGILFLLPLYLIYVNIGRTIGINLYGSYLGLIITYLTFALPFSVWMLAGFFASIPTTLEEAAMVDGTGYWGALLRIVIPVARPGIVAVAVFSFMTAWGEVLFASVLTTQSTRTLAIGLQEYATQGNTAWNELMAAAVVVSIPVVVGFLALQRHLIRGLTSGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX44</accession>
    <name>A0A7K0JX44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001052">
        <property type="protein sequence ID" value="MST34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="21572" checksum="3E4D65AB608D6C03" modified="2021-04-07" version="1">MSTPEPVATLEDAMGVDQLELEVRQLAGVTFVGVGRRDGSLLVEVAAADGADLASLRAEVHRLAAALVDGPVVVEVLGRTDENRPEARVRLQVTLPLPGTTAAELHLAYRQRRTAVQADESDGLAVAGAVLAGLAALGLPAPWSATAVHALPEEIGAGALVVLEHHRSGETRRGVARGRSQADAVARAVLNALNRFLEGARPGGAGAACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ2</accession>
    <name>A0A7K0JXJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_18300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001136">
        <property type="protein sequence ID" value="MST34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="16654" checksum="FD752B78174269A7" modified="2021-04-07" version="1" fragment="single">DAGAVDFDDQVYGAIESLLADGELRASCRLACRHLLVDEFQDLTPAHVLLLRLLASPAFDCFGVGDDDQVIYGHAGADPAFLIDYERLFPGAGDHPLEVNYRCRPEVVRAASTLLGYNRRRVPKQVRPGRGDPPPGSPPPLEVRLHEPAGGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR7</accession>
    <name>A0A7K0JXR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001195">
        <property type="protein sequence ID" value="MST34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="221"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="372" mass="39878" checksum="2B1B7453244C0047" modified="2021-04-07" version="1">MNFAFSEEQEELRRAVRRFLEDKSPETEVRRLMETESGSDPAVWKQMGEQLGLQGLAVPEEYGGSGYGYVELVVVFEEMGRALLCAPYFSTVALAANLLLAAGDEAARKAYLPGLASGAQIGTVALAEASGRWDEAGVTLEATEAGDGTWALTGEKRYVTDGHLADLVLVVARSGAGVSVFAVERGAAGFESVPVPTMDQTRKQATLTFSATPARLVGEDGQGWAAVSSMLDKAVVALAAEQVGGAQRVLEMAVEYAKARVQFGRPIGSFQAIKHKCADMLLEVESAKSAAYYAGWAAAEDNDELPVVASLAKSYCSEAYFHAAADNIQIHGGIGFTWEHPAHLYFKRAKSSELLFGDPTYHRELLAQRIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS0</accession>
    <name>A0A7K0JXS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001202">
        <property type="protein sequence ID" value="MST34765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="174" mass="19628" checksum="B6EB2F7D6460BB1E" modified="2021-04-07" version="1">MHERWTVRWFRKRALVYHLLVAIIAPGCAVAADWQIHRAMGGNLLSWLYAVEWPVFSILAVVGWWQLIHEDPARVESRKVERARRAATKGPFVPPPPDSASGFYHPLQVASRPELAAELGRDLPVLREDDGELVAPDDATPVHQLSEYNAYLARLAVGRTRKSWRNPHGAPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW6</accession>
    <name>A0A7K0JXW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family 43 glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001216">
        <property type="protein sequence ID" value="MST34790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="291" mass="30681" checksum="4ED57D017A6AEC95" modified="2021-04-07" version="1">APGAFADPSVLPVPGGYVAFATGGPDRQVKVRTSQDLAHWEEGGDGLAALPGWARPGRTWSPAALRRGDGYVLWYATWHRASGRQALSVAVADRPAGPYLDTSSGPAVFQEDQGGSIDPSPFVDADGQAYLVWKADANAVGRRAGLYGAPLDGAGTALAGPPVHLLAHDRRWERPLIEAPCLLRAAPGRYLLLYSGGRWHTAGYAVGYAVAGHPLGPWRKVTRRAPWLHSDPVGSGPGGQEAFTAHDGRRLLAYHAWEPGRVGGSGVRSLRLGELDLTGPEPRLVPLPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY34</accession>
    <name>A0A7K0JY34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001004">
        <property type="protein sequence ID" value="MST34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="382"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="552" mass="61140" checksum="C08E12299F60E870" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY44</accession>
    <name>A0A7K0JY44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001009">
        <property type="protein sequence ID" value="MST34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="62" mass="6323" checksum="3AD39955D9D81B8A" modified="2021-04-07" version="1">MPPAASKAPVDYLAAAAVGILVMVVTIWVQPAGTRWVVFAVGALILLSALAAGARPSRPSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA0</accession>
    <name>A0A7K0JYA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">whiG</name>
        <name evidence="9" type="ORF">GHK86_19695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001315">
        <property type="protein sequence ID" value="MST34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="336" mass="36500" checksum="9B5D6EBBD34A320F" modified="2021-04-07" version="1">MVATGPVTHSRQRAAVRSCGPAEQPVPFVSCDRSHPVLSRRPSVTESEGRKPGVPAPALAGGGTGGAALEDLEAAERAAEARAEAERQAIARLWTDYKATGRRQLLVHYSPLVKYVAGRVSVGLPHTIEQADLVSYGMFGLIDAIEKFDAERNIKFETYAITRIKGAIIDELRSIDWVPRSVRAKARAVEQAYAKLEASLLRTPSDSEVAAEMRITEAELQQIFTQISFVGVVALDDLLTGSDREDSTTLGETIADRGDGPMATFEVEEMKQVLAGAINRLGDREKVVLTLYYYEGLTLAEIGQVLGVTESRVCQIHTKAVLQLRARLLLAERSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA7</accession>
    <name>A0A7K0JYA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1049 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001318">
        <property type="protein sequence ID" value="MST34943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="6">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="10614" checksum="5FBAB78AC1FA1B4E" modified="2021-04-07" version="1">MAQSPPRPSQSPPSARRWLFGWPASAVVAAAALLIFVIQNTEDVTFRFVILTFTWPMWLYTVVMAVFGAVVWMGVGVLRRHRRRKERRAQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG7</accession>
    <name>A0A7K0JYG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001355">
        <property type="protein sequence ID" value="MST35003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="9594" checksum="B92BED8B50ACADAA" modified="2021-04-07" version="1">WHAHQRSHRLERARFERLTRREREVLAMLMAGETVERIATRAVVSHATVRTQVHYILMKLEVNNQLEAVALAHRVGWSADGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP3</accession>
    <name>A0A7K0JYP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF2309 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_20340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001397">
        <property type="protein sequence ID" value="MST35066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018752">
        <property type="entry name" value="DabA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38344">
        <property type="entry name" value="PTHR38344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10070">
        <property type="entry name" value="MpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="19525" checksum="1A5890D9998FD129" modified="2021-04-07" version="1" fragment="single">MPPPETAGSVSARAGRRLATLAPERAALVWLTAWEGHVRDRLLAALEDGGGDDPGEPIAQVVCCIDVRSEGLRRHLERLGPYQTFGFAGFFGMPARVWPDGSDQPLDLLPVLLRPGVELGEDDPGAERALRLAAAGRAAEAGRKGVLSAFLLAEAAGLALGPLAVMRTAAPRSATRLRGRRAAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ35</accession>
    <name>A0A7K0JZ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001511">
        <property type="protein sequence ID" value="MST35197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="14252" checksum="89CFC79E3C3A7525" modified="2021-04-07" version="1" fragment="single">MVALPAGSGQPVGLSWSADGRWLAFLRVPAGQQGPAGAPGSLWVVGADGHHLRQVVAGPAVGTFAWNPARDTLALSVVAGATARAHPLALVPILASGRPGVAALPGGLTGAYVTGVAWSPTGTTLAAGADAPKPSGALGELVTVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA9</accession>
    <name>A0A7K0JZA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_21190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001536">
        <property type="protein sequence ID" value="MST35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IGPS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14169" checksum="60E2E52FED9E6310" modified="2021-04-07" version="1" fragment="single">ACLSVLTDGEFFRGSPADLAAARAATHLPVLRKDFTVGPADVCDARILGADAVLLIAAALSPLELTELKALADDVGLDALVEVHDEEEAGAALAAGATLVGVNQRDLVTFEVDTARAERVARALPAGVTRVAESGVGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC9</accession>
    <name>A0A7K0JZC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001620">
        <property type="protein sequence ID" value="MST35320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="11467" checksum="1E59DB4347572B6E" modified="2021-04-07" version="1">MPLAMAALDTGAAIDRVTGAMDRLGFRPVADERRILLRHCPFADLARAERTVVCNIHLGLLEAAFDDLGAPVGVERLDPLVQSDPLLCVAHLRTRERNPHDRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH9</accession>
    <name>A0A7K0JZH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001642">
        <property type="protein sequence ID" value="MST35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="18310" checksum="9DB44AA77D9B50D1" modified="2021-04-07" version="1">AEARRAVGLVPQDPADLLYLDRVDAECAQADRDAGDAPVGTAAGLLARFAPGVAGATHPRDLSEGQRLALALAVQLSAGPGVVLLDEPTRGLDYAAKAALVAVLQDLAAEGRAVLVATHDVEFVAAVADRVVVMATGEVVADGSTAEVVTASPAFSPQVAKILAPLPYLTVDQVAGALAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMG0</accession>
    <name>A0A7K0JMG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1269 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000006">
        <property type="protein sequence ID" value="MST31146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046288">
        <property type="entry name" value="DUF6325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19850">
        <property type="entry name" value="DUF6325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14822" checksum="A683FF4370FC7A47" modified="2021-04-07" version="1">MGPISYLVVEYPRNTMTGDGLRILLDLVDRGLVRVLDFRFVTRSDDGSIRALEISDLDSDDLATLSLFEGASSGLIDDSDLGEAAGVIEPGSSAGILVFENRWAAGFTTALRRGGAEVVAAGYIPLDEVAAALDATETAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW7</accession>
    <name>A0A7K0JMW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system protein GspE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="611" mass="66560" checksum="1C6371C06C48D9AA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMY2</accession>
    <name>A0A7K0JMY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="339" mass="36386" checksum="74FD734E72168092" modified="2021-04-07" version="1">MERREFLTGAAAVLGGALLPLLCDLGAPPSPDPDEFARQAAQLWANCWSSEPLTLVYRAADHAEHGRTLLARSRGSDHRRIADATGLTTLLVGRTAFFDLGQAAATQEVLAVADRYLAGSPDHPLLACLHGHQAFVPGWSGRWAEAEKELAIAAGHARRGGGPGLRAWLHAVAAECLTRAGKPREALAEIERSRETLVAGGAHPDPWWLDYFDAKRLDGFDATVALAAGREVLSTGISTQRATRHALDRVERALGHLHTTAAEPSGYTPQDCVTVLDRATAYALIHDDDQALRLAEAACRALAKRPYAAAHGRLGTLYDTLPANRAGKLREIELTYLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMZ2</accession>
    <name>A0A7K0JMZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000028">
        <property type="protein sequence ID" value="MST31273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="28661" checksum="68BF87636E976A94" modified="2021-04-07" version="1">MVLGLIFLLPLLWAVFESFEPAGAVTSPPRLSVLGHLGISNYVQLINGNVHILDYVLNSLWVSIGAALLTSGLSLLAGYGFGRFRFRGSGTLFSLTLLALMVPFQAVLTPLFLELHAMNLTNSRVGLLLFYATFNLPFGVFVMRNTFSQIPGEIEDSALIDGASVLGTLWRVMRPLVLPGVATTLLYTFLFSWTEFLGALTFLTTQSRYTLPVALLNVETGTYGAVNYGHLVAGAVISMIPVVILYVALQRYYVQGLMSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI4</accession>
    <name>A0A7K0JNI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000009">
        <property type="protein sequence ID" value="MST31154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="17971" checksum="B7405FDD4CF43F46" modified="2021-04-07" version="1" fragment="single">MSETVPPTAVRLGGAVVRAGCCSWADRSLVRDGGFYPRKTMTARERLAFYAEQFPIAEVATTFRFPPTPELCAQWVERTPPGFVLDVRAWSLLTGCPTLPDSLWPDLQGAVHPDRRDRRRLYPQHLPADALEECWARFRHALQPLVDAGRLGAVLLRYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP9</accession>
    <name>A0A7K0JNP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000019">
        <property type="protein sequence ID" value="MST31209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="14"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="23239" checksum="0D57374E31FCA10E" modified="2021-04-07" version="1">VTDVWSLPYARRPGSAAGLNAASAALAADPPGDLRVVGGATVHPGDDDPAGLVRAAIEELGLRVLKLHCSVGDYRPDDVRLDAVWSYASDLRLPVVVHAGHAVSGHTGAGELEPVATVARRWPEVPLVLAHCGHPATAEAWGLVASHPGVHVDLTPVVHDAVPLDAAVIAAHAERVLFGSDAPNTAWSVPELVGRLRRLDLAAPALDAVLGGNARRLQDRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX2</accession>
    <name>A0A7K0JNX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000110">
        <property type="protein sequence ID" value="MST31658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="370"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="596" mass="62412" checksum="38F4080AD53F1526" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX6</accession>
    <name>A0A7K0JNX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000111">
        <property type="protein sequence ID" value="MST31666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="24536" checksum="C803928B635C23CF" modified="2021-04-07" version="1">MQFPPDPITGARRQPSGSAATEREAVRLERTFRLQAQDGASGDITLARLVEEWWASQPRLAATTRVNDRDDLDNHILPALGSRKVWELRPRLIAAFLRDLSEQRGLKPGTVRKASPVLSAVRSYAAATEYIEANPVMRVPPPEAAPSGPVAPTVEEIPIILSCRPTKLSSEATSCSESRGPARPTHRSCAGHPETAPAPVPWPSRQHHRPARLERPATAPGDGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP14</accession>
    <name>A0A7K0JP14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8582" checksum="3533FC30C8355230" modified="2021-04-07" version="1">MSELRDVLWFRGLCRAGTARAVRQVGCVGLGEAARAAGVAKSSVSRWERGLQQPRGEAAVRYARWLHSQVALVSEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP54</accession>
    <name>A0A7K0JP54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000110">
        <property type="protein sequence ID" value="MST31661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="7619" checksum="44D2ADE76A9BB2C8" modified="2021-04-07" version="1">MDAPPPQGPPIPSTGPPAAPETTGPGTAGTFTVDDIDEETMQWIMEHVQRRVLDELERRGRYFDPRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP56</accession>
    <name>A0A7K0JP56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000128">
        <property type="protein sequence ID" value="MST31746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9031" checksum="70C6A467D1BA3285" modified="2021-04-07" version="1">MILGTLSSSAGSFSELRRGLAPITDSVLSDRLNELVEAGLVSRCVSDGRPPGVRYALTDAGAAIVPVLDQLARWATDHLPPTPGDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP73</accession>
    <name>A0A7K0JP73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="7983" checksum="AC4630264C4F6FCC" modified="2021-04-07" version="1">MKAAVDSVGRIAVPKPLRDALGLQPGTEVEISGYGAGLQVVPSGRAARVVLEGGVPVATGDTRIDDATVFGLLDAGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP85</accession>
    <name>A0A7K0JP85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="493" mass="51333" checksum="54321BFB67570514" modified="2021-04-07" version="1">MGRRRGGRAGRGLGRDFWLYFSGQAVSQLGSSFTTFALPLLVYRLTGSATNLALTTVAEFVPYLLFGLVLGAVVDRVNRRRMMLRADLARAAVIAVLPVLSMVGALATWNIYVVAFVQATLGILFSCGEFAAIPSLVDDQELVTANARVLAANNVGPILGPTIAGALVTFVPVAQLLFFDAGSFLVSVGCLAVIRRSFNAGTQRAAPAESVVRSLLADVGEGLRYVWGHPVLRSISLMMALINFVFSTVSAELVLFAKRALHASNSEVGFLFACGAAGIVVVSLLAGPIRRRLSFALTSLGALVVSGLTLTAMALAHSYPAALALWGASTGFGLLLNINTGALRQAIVPPQLFGRVASVGRVLAWSAIPVGSILGAAAIHATSVTAVYAVIGVLMAAIALTFALSPVAAGDRYLAEAAERQRIGATAPPEWPASPGGGTRRRPGPVARMQVRESGAAPGYSPDLQGATGSGARSRRSLPWRASNPRDGSQPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE1</accession>
    <name>A0A7K0JPE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_03625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000145">
        <property type="protein sequence ID" value="MST31818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029871426" evidence="7">
        <location>
            <begin position="23"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="54"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="479"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="717" mass="73567" checksum="CE7DDAE752711F67" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF9</accession>
    <name>A0A7K0JPF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000067">
        <property type="protein sequence ID" value="MST31439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="6978" checksum="A8E4DB961CAF1151" modified="2021-04-07" version="1" fragment="single">MTESSSPLETALDLFVYVPVGLAVTLSEEVPRLAAKGRDRLGPTLATARMVGQFAVGQGRRMASGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG1</accession>
    <name>A0A7K0JPG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029645149" evidence="2">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="81"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="383" mass="39751" checksum="01E9CAB84521F31E" modified="2021-04-07" version="1">MLLVAACGSTSATGSNSTSSGSGSASSASGSSSGGGSTSSANLSAVRSQLAAYSHLPTFKAPGPAFNARKVMAGKTIFSIPVNSADQFVQILEQGNAAIAHQLGFKYVDYTNSGSLSSWVQGMQTAVNEKANAIDLLSGINPAQLGPQMAAAKSAHIPVIASDAYDLNEPAAPGLSAVMDVPYAEAGRLMAAYAISATSGKANVLVIGSNDVVSSPYMVNAINGEFSKYCPTCKVKDINIPVADWATQTQTQVEADLNADPGINYILPVYDSQSQFVVPAITAAGRTGKVFIATYDGTPFVLKMMQDGNTVKMDVGEDLNWISYAVMDQDMRVAAGMKPSPNENTPMMIFTKSNVNTAGVPPRNSTGYGSSYIAGYKKLWGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN8</accession>
    <name>A0A7K0JPN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000160">
        <property type="protein sequence ID" value="MST31871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1016" mass="109777" checksum="BAB96980364BF6F5" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT8</accession>
    <name>A0A7K0JPT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="199" mass="21700" checksum="BC3E0C91D166462B" modified="2021-04-07" version="1">MTQEREATEAAAYLSTLEVRWIVAGPRAPETLRWFVRFPTVTERRVDRYLLHGQLAAGCALKIRGASLLELKLQRDDGRVLDVPGFAPAGVKRCEKWSFPLADVAGGLPVVSSWKQVHKTRWLSRPGGEQAPCAAELTDIRVDGVESWTIGLEAPGSDERAWDALRAAAADLFAEPLPAAPAAATVAAVPYSEWLGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ77</accession>
    <name>A0A7K0JQ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2269 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000213">
        <property type="protein sequence ID" value="MST32102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018729">
        <property type="entry name" value="DUF2269_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10027">
        <property type="entry name" value="DUF2269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="17227" checksum="3CAE711373EE9633" modified="2021-04-07" version="1">MGPGYDVLLVLHLLCVIGGFGYLAYSGLVLVLGRRRGASLGTLEVTQQVGTLAEMLIYGAFVFGIAAVGSSHHWHFGDTWVWVSIVLFVVAVGLLHGVIRRSQREYAALANRVAASSGPVASDDPQVVRIERLERRLVAGWGAFNLFVVAVVALMVVRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA9</accession>
    <name>A0A7K0JQA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine O-succinyltransferase</fullName>
            <shortName evidence="3">HST</shortName>
            <ecNumber evidence="3">2.3.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Homoserine transsuccinylase</fullName>
            <shortName evidence="3">HTS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">metAS</name>
        <name evidence="5" type="ORF">GHK86_05095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:22008"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="EC" id="2.3.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.46" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000213">
        <property type="protein sequence ID" value="MST32103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="36679" checksum="489BE97EEE78DE6E" modified="2021-04-07" version="1">MREGRTSVPDRIAPGATVVPTRSPLHLAFVNSMPDGAFEETEQQFLALLGLDLGGAGGGPAVDLRRYAPEERRASSEIPTGVRRRYAPADALFATSPDAVVVTGCEPGAGRVQDESLWPLLARIFEWAPAATASLWLACLAAHAALAYFDGLDRRSLPAKASGVLPQEVTAGDPLTAGLPAQVAIPHSRLNEVPTPALVAAGYRLAIASSSTGWTVATGRRGRCALVLVQGHPEYRADTLLREYRRDVRRWLKRERDDYPPVPSGYLDDAAEARFAAFRRRAQAGPRTAYLMEEFPFAEEAARLEAPWLPVAATLGRNWLSTLAGGDGPGGNGRAPEVPIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE1</accession>
    <name>A0A7K0JQE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_05175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000217">
        <property type="protein sequence ID" value="MST32117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="170"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="415" mass="45427" checksum="5F3FCB8E1BACBCDE" modified="2021-04-07" version="1">MSGSIRKRGEGSWQVRVSTGARDPASGRYLYAERHVRGTKRDAQRALDALSVEVARGGHRQQAKRRTVSDLLEAWMAHLEAQGRAPTTMHRYRTAIRANINPHLGRYDIARLGPAELDAFYAKLLKSGLKPLSVRKSHAVLSAAYSQAVRWGWVERNPVLRATPPPSRGKEIRPPTMTELGRLLQECNKAHPDLAALLHVAATTGARRGELCGLRWGDVDLERGTLTISRSISDAGSEVDVKDTKTHQARRLALDATTLDILRLHRERVEERAMLAGATLGPGSYVWSQAIDASVAYRPDRVTGAFRTLRDRLDLPHVTFHGLRHFTATTLASQGVPVRTIAGRLGHANPGITLRTYAHYLDVADQEAADAIGLAVGALYPASANRPSASSSALRGTTTRRPRRTDGSSPRATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK1</accession>
    <name>A0A7K0JQK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000241">
        <property type="protein sequence ID" value="MST32201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="449" mass="47764" checksum="59F5188F49A0D71F" modified="2021-04-07" version="1">MPPGTGGAPAADEDLEGLQRRLHELEEQNARLLGEQAAADRRRREHHRARTTLAAVLVILGAILAPLSVVSVWASNTVGSQDQYVATVAPLATDPAIQSAVTTRVTDAVYTRIDVPALVSGALPPKAEVLTQPISNGVKSFINTVVSRIVTSPQFATLWEEANRAAHAQLVGALEGTSPAGVSVHNNQVTLDLSQLVSQVKSQLSASGLTIIDKIPTGSIHGTVTVFQSDKLGQIQGLYNALQTVGVWMPIIAAALLVAGVLLAPRRRRAIAWAAFGVLVMVLIATLLFYLGRNYYLTHLPPQIQSRAAAAAAFDILTRFLRQSARTLAVAAVVVWVVAFVSGPARGAGTVRHAVTTGAGGLGDRAERAGLLPVPVRLFVARFHRWLQIADVALIVVILLLWSHRTGADVIWMSLLGLFLLLVIEFLGVRSAAESPPSREDRLGSASPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL6</accession>
    <name>A0A7K0JQL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="20428" checksum="F5C9467B35BD1825" modified="2021-04-07" version="1">MRSGRVWLVVGAAAGVAMALGHFPYLAGAARTLAATALSLVGSGGHAIIRAAAHHGASRRVILGATAVIAVLVTGVTAWLCVVAAKGTLRLRSLLALILLVLGAASFAYHPGGVAGGTLLLAVAAGGLALVLTGPLVAAPLAALAGLLAGAYLPALLLRGQIGQPVVEALHQAIYGQPGTSVALHALLLVIAVAPFLLALRVLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM1</accession>
    <name>A0A7K0JQM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000164">
        <property type="protein sequence ID" value="MST31884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="86" mass="9694" checksum="929AAC3A4D1FD108" modified="2021-04-07" version="1">MDDNSCFNRGRTIPGPASPPRSACEPCGELPDLTRDRLGRIDGRQLVHVACPRCDHDWWEIDGRPAPFREVSDLLAADCERLTPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS7</accession>
    <name>A0A7K0JQS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">gatB</name>
        <name evidence="13" type="ORF">GHK86_06035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="WJHE01000262">
        <property type="protein sequence ID" value="MST32281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="12">
        <location>
            <begin position="335"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="479" mass="51122" checksum="F962C95F943E9A71" modified="2021-04-07" version="1">MTTTGTTWETVIGLEVHVELGTETKLFCSCPNRFGEEPNTNVCPVCLGLPGSLPVLNARAVEYAARIGVALHCTVQPSLFHRKNYFYPDMPKDYQISQYDVPIDADGWLELPGGTRVGIERAHLEEDTGKTTHLGGGGRIHDADHSLVDYNRAGVPLVEIVSRPDLRSADDARAYVDELRGILVAAGVSDGKMEEGSLRVDANVSVRPAGSERYGTRCEIKNMNSLRSLGRAIDYEAARQVQLLEGGGTVTQETRHWNEDEGRTSSMRSKEEAFDYRYFPEPDLVPLRPDPAWLDDIRASLPPMPADVRRKVAEAAGMAPDVDAVITVVRLGLDPYVDAAVRAGADGNLAVRRLANEVAADAASVGNLAPAAFVALLRMESAGELTTAQAREVLKELLASGGDPAAIAAARGFEALGEDALAAALDQVIADNADAWARFVGGEDKLQGLFIGRLKGATGGKADLAAAAALLRARRAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT5</accession>
    <name>A0A7K0JQT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_05905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000258">
        <property type="protein sequence ID" value="MST32257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="45"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
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    </feature>
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        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
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        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        <location>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
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        </ligand>
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            <name>[4Fe-4S] cluster</name>
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            <name>[4Fe-4S] cluster</name>
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            <name>[4Fe-4S] cluster</name>
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        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        <location>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036298-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31652" checksum="3B0BE729CDF82075" modified="2021-04-07" version="1">MAPASTPLSLLSSVRGHGDPATDTGWEDHPPRMGFFTDTSICIGCKACEVACKEWNHVPDDGFSFTGMSFDNTGGLGADTWRHVAFVEQRKPLADQEANTQHAGVAGDELRWLMASDVCKHCTDAACLDVCPTGALFRTEFGTVVVQEDVCNGCGYCVPACPYGVIDQRKDDGRVWKCTLCYDRLGVGMEPACAKACPTNSIQFGPLEELRVRADQRVTELQASGLTDARLYGHDPHDGVGGAGAFFLLLDDPEVYGLPPDPVVTTRDLPRMWKRAAVAAGSLLAGIVALGIGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW1</accession>
    <name>A0A7K0JQW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2254 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000188">
        <property type="protein sequence ID" value="MST31979.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
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            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="158"/>
            <end position="177"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="508" mass="55213" checksum="D8D5FE8E04C5B87B" modified="2021-04-07" version="1">MGGVARRDRPHRRRGSCSRYPYRPGPVGLGHGDVPRPRRDHGATSDGRRGEGDVNEWTRAGRLHHYVETAMWPIPAAYLLAAGVLGIGVPRIDRALGSSVPANFGTGAAQTLLSAFATGLITVMGFIISVVIAGLTFSGTTVTPRMVREMQRNTTIRHVSGLLLLSVVYAFLVLNRVAPPDEPNYVPDLAVWLVVPLMVLDVIGLLLLVRQMGHSLRLVEIIDSVYHRAEQVIATIYRDPLDVEGNGASSTDRLDASGCTHVNQERSGVVAAINVRELVAEAKRADTVFELACAIGSYVPAGGPLLRIADQRARVDENRVQRAIVIADERTIDQDPMYALRLLVDIATRALSPAVNDPTTAAQVLDRIEALLGRLAGRRLDRSAICDEDGDLRLVALLPSWDDFVSVGLTEIRQYGATSAQVMRRMRALLDDLLLATPGCRHPALEHQLALLDKTIDGVYQLPLDAELARIPDRHGLGEPAAARQNGSAARSARRPAASLVRPRNEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW2</accession>
    <name>A0A7K0JQW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">GHK86_06115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
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            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000265">
        <property type="protein sequence ID" value="MST32297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="32404" checksum="994C7C7F148CB6DB" modified="2021-04-07" version="1">MPTADASVRLSDVHKAYGTVQAVRGVDLAIRPGETVALLGPNGAGKSTTIDLVLGLARPDAGQVRVLGEQPDDAVRNGRVGGMLQTGTLIEHLTVGELVRMVASLYPRPRPVDEVLELTATAPLAGRDTTKLSGGQTQRVRFALALVGDPDLLVLDEPTAALDVEGRRDFWSAMRAVAGSGKTVVFATHYLEEADAYADRIVLLAGGRVAADGTANEIRARVGGRSIRATLPGADLAALRELPGVSSVDRRGDAVVLACTDSDAALRRLLDRYPTARDVEVRSAGLEEAFLELTTGDAVAPSMDEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR03</accession>
    <name>A0A7K0JR03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="8543" checksum="64ACA712449A82E3" modified="2021-04-07" version="1" fragment="single">MPVRDEVRDAQRTLAALDAAHTRASTRLDQARARRVEVLAEADLAVAAAQEGVEAAVAQMAAGVGVELTSQMLGVETTEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR09</accession>
    <name>A0A7K0JR09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000281">
        <property type="protein sequence ID" value="MST32378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="18145" checksum="BFB03D601F25C6D0" modified="2021-04-07" version="1">MAVLAGLMVAVTASRWFVDRAGEAVALLYVVPIALAGLRFGRRGSLLTTGIGTAAFAGLELTRARGDIDVTGWVAPLLAMTLMGVLVGRLSDSTATNQATVRLQADRLEELDDAWRATARAGDSIVQQVAAARWMLEAGNGPGALAALEATVAEGISELSSSLSPFTPARAPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR86</accession>
    <name>A0A7K0JR86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Squalene synthase HpnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000299">
        <property type="protein sequence ID" value="MST32458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480:SF17">
        <property type="entry name" value="PTHR31480:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="23411" checksum="3F135B8C82A1A4C4" modified="2021-04-07" version="1" fragment="single">MGTERAPSPPAPDRLPSAGEVLGRMGGENFPVALRVLPRSLRDRLRAIYGYARFVDQLGDAYDGDRLGALDWVEGEVERGLSGAAPVVDLHPLVAPAVALVRACGSGADELRALIQANRMDQTVGAYPDFAALVGYCHLSADPVGRLVLLAFDASTPERVAWSDRICTALQLAEHWQDLGEDVRAGRLYLPADDRARFGVGEEELRAVAGRRGPAGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC7</accession>
    <name>A0A7K0JRC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000308">
        <property type="protein sequence ID" value="MST32481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="80" mass="8071" checksum="F328D10B9D84DE42" modified="2021-04-07" version="1" fragment="single">MAAGAAGLCGLPGCGLLDPLPSLGGSVARALAGGVFAAFTTAERVAATWIVRHVLHLLTPGTEVRLGTGTWFATTVRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD5</accession>
    <name>A0A7K0JRD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000306">
        <property type="protein sequence ID" value="MST32477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="369" mass="38483" checksum="E8D05768A7F45C26" modified="2021-04-07" version="1" fragment="single">MAALLRWRGPAPRSSAARSGPTAGAAATVKDRGNQAQQRSSRRSRLRIVVTGGSGFIGRHVVGALLARGDQPVVVGRRRFPGDVESVVGDLRDPAVVAAAVRPGIDGIVHLAGVKSVLRSVEDPHGVFLDNVAVTEALLERNRATAGAPVVFASTNALCGDVGDRLIDESVVPRPLTPYGASKAACEALLSAYAGSYGIRSVALRITNVYGPGMEEREGGIVAAVMRAARRDEPLVVHGDGGQRRDYLYVTDAVDALLLALGLPDPAVFTVGAGRDVSVNELVELASVAAGRPIAVRHVDAEKREMPRVAVDASRFRAAGFAPAVSLEEGLRQTWRSFQAMPDPTPAAPARPPATARPPAPTPGPTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI7</accession>
    <name>A0A7K0JRI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_07300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000321">
        <property type="protein sequence ID" value="MST32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="20830" checksum="F916B1142E7AE3FF" modified="2021-04-07" version="1" fragment="single">MTTEPGPAGPGPAPVPAVPPRGGRAARRPGGRGLLLRWPVLGLAPFAIYALVFLAWPLADVVAGAFESSKPGGGITLANLHAAFSGVYRQGFVTSVELAAITAVVPGLVGLLVAYAVETSPHGTLRRVVATASGVFANFGGVPLAFLFIASIGSTGMVTRWLTAIGVDPYDHGFTLYSFTGVAIVYLYFQIPLMVLVVTPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI8</accession>
    <name>A0A7K0JRI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000241">
        <property type="protein sequence ID" value="MST32199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="909" mass="103175" checksum="2A2B94D404EDE77B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS0</accession>
    <name>A0A7K0JRS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_05995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000261">
        <property type="protein sequence ID" value="MST32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="342" mass="34639" checksum="2CEE14F8E74C2EDB" modified="2021-04-07" version="1">MRGNRHRHGRPGAAAAGVPPDGGVHGGVVPEGGGAHGHHDGPGHAHGVAADADARYLTVALVLIASFLVGEVVAATLSGSLALFADAGHMLTDVVALAGSVWAARLAARPAAGIWTFGLKRAEILSAAGNGVTLAVIAVVITIEAIRRLVTPPGVDGAVVLGVALVGAAVNVAATAVLARANRTSLNVTGAFAHIVTDLYAFAGTALAGVIIVVAGWTRADAVASLLVAALMAHAAWGLVRDAGRILLEAAPDDVALDQVRAHIAGVEHVLGVHDLHAWTVTSNLPTLSAHVVVEDHCFASGHAPQILDALQACLGEHFDVEHSTFQLEPASHVAHEHGQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS14</accession>
    <name>A0A7K0JS14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000370">
        <property type="protein sequence ID" value="MST32731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="111" mass="11581" checksum="DB6587B02D428A8F" modified="2021-04-07" version="1">MTGGEQLPAPSGPGTVVLDIGGDIGAAVVSTPPQLLGEELEIRPGSGPWTGRHVAVLARPLGTRTRSAAVFPSLDAGPWVVRRRHRPEDPTEVAFAVEGGRVTSVTWPEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF6</accession>
    <name>A0A7K0JSF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="10125" checksum="63CC0AC3D304CBEE" modified="2021-04-07" version="1">MSSARRPLGEVRRPPDPGEWVTLEQAATMVGYSRDGFRELAARKGITTRRRGPLPGVSRAEVEALLAAAKIAPGELRRAAPGWFSTRKQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK4</accession>
    <name>A0A7K0JSK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tam</name>
        <name evidence="3" type="ORF">GHK86_09355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:14969"/>
            <dbReference type="ChEBI" id="CHEBI:15708"/>
            <dbReference type="ChEBI" id="CHEBI:57470"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.144"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Tam family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000432">
        <property type="protein sequence ID" value="MST32921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00560">
        <property type="entry name" value="Tran_acon_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023506">
        <property type="entry name" value="Trans-aconitate_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="260" mass="28094" checksum="CBD88C8D4D57F67A" modified="2021-04-07" version="1">MWDPARYLAFAGERERPFHELVSRIRTEPAGLVVDLGCGPGSATAQLADRWPDARVVGVDSSPEMIARAEERARPPRLTFVRADVTAWEPDGTPDVIVANALWQWVPSHLEVLGRLATRLAVGGTIAFQVPGNFDAPSHTLLRTLASSGRWPLPAGLLRAAPVLEPAGYLGLLARLGLEADVWETTYLHVLHGADPVLDWVRGTALRPVLGALAPEAAAEFEAAYGAALRAAYPADDAGRTVLPFRRIFAVGYRRAEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW9</accession>
    <name>A0A7K0JSW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_09955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000464">
        <property type="protein sequence ID" value="MST33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="34211" checksum="1C4B858C0637FBF5" modified="2021-04-07" version="1">MTIYILKRLVTALIVVIGVTMVTFGLLHVISSSPGRAVLGLHASPAQVAAFNKAHGYDAPIYVQYVHYLNQLIHGNLGYSYKMDQSVSALLGENILRSVWLSGASIFLAIICAFPLGIYQAYRRNSVSDYTLTAGSFILYSMPSFFLGLLLIQFFALDLHWFPVQGAQQTNILAVIANIHAMALPIVTLAAIQLAAYSRYMRSAALDNLAQDYIRLARAKGLSERAVLARHLLRNSSLPMITLIGLSIPALLAGNLITETLYNYPGLGFLFYTALQNEDYPVLLAITLIGAIAVVIGNLIADVAITVADPRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX7</accession>
    <name>A0A7K0JSX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000361">
        <property type="protein sequence ID" value="MST32684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="25962" checksum="C4793239CE0ACDF3" modified="2021-04-07" version="1">MLTVRYDRLGVRPGDRLLDLGAGGGRHAFEAMRRGAVVVALDADAGEVKDALGMMAALTAEDASTRAQGGAGAATVGDARRLPFADGAFDRVIAAEVLEHIHDDRAAIAELARVLRPGGTIAVTVPRWLPELVNWALSDEYHETPGGHVRIYRRSTLERRLADAGMVVTGHHHAHALHSPYWWLRSAVGVQRDDHPLVRAYHRLLVWDITAATPLTRVPEAVLNPVVGKSAVVYARKPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ0</accession>
    <name>A0A7K0JSZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Slipin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000471">
        <property type="protein sequence ID" value="MST33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="251" mass="27616" checksum="5EF980F6D4631681" modified="2021-04-07" version="1">MPALGIAIVHQYERGVVFRLGRVRGVRDPGWCWMIPLADHMRKVSLRTVTLPIQGQQVITRDNVSIGVAAVAYYRRTDPVKSIVEVESVETAINQIAQTTVRNVVGRSKLDQVLSETETLNADIQRVLDVTAERWGVVVQLVELKDIELPQAMQRAMAREAEAEREKRAKIIAAEGEALSAGKLAEAADVIVEHPVALQLRNLQILSEIAVEKNSTIVFPAQFIESVRAIERYVDAEAAAAHRNGASAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT09</accession>
    <name>A0A7K0JT09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000353">
        <property type="protein sequence ID" value="MST32659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="13834" checksum="19F28DEF6F45DCD8" modified="2021-04-07" version="1">MCVGAVAVDRDRLLLVRRGHGPGAGWWSVPGGRVEHGETLAEATVRELREETGLEGVCGELLGWVERIEDPHHFVILDFVVTVLDPSGPVAGDDAAEVAWVPLADVADLRLVDGLAEFLHDHGILATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT74</accession>
    <name>A0A7K0JT74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molydop_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000492">
        <property type="protein sequence ID" value="MST33127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molydop_binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="11429" checksum="FCD0D412CF2787F1" modified="2021-04-07" version="1">PPAAGELRLVSRRTLWDAGTQVAHAAHLAPLARAAAAALHPDELLTRGLTPGGTVTVSSGRGQLTLPVVADPAVAPGSVAVPFNLPGHPAASLIDAADSVVTVRVQAVPVADGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA5</accession>
    <name>A0A7K0JTA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000504">
        <property type="protein sequence ID" value="MST33168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="3">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="3">
        <location>
            <begin position="111"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21065" checksum="C6F7D37F8A91F98F" modified="2021-04-07" version="1">MASLRDSVVELCALVSEALARATWALLNADPVLARDVVDADSDVDRQTAALEAELWREVDAGGGTRPVRELVAALLVLPELERSADLAEHIAQRAEGGLGADMNPASRGVVQRMSEVAITMWQMTTGAFLSGTSSPEELDEADEELDVLHERLTAIVAGGGMDPAVAAQVTLLARFYERLGDHAVNLSRRVGAFTATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD7</accession>
    <name>A0A7K0JTD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis protein CheB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000524">
        <property type="protein sequence ID" value="MST33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011247">
        <property type="entry name" value="Chemotax_prot-Glu_Me-esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036461">
        <property type="entry name" value="Chmtx_methlestr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="339" mass="35473" checksum="4D6B4CBF0B3197CE" modified="2021-04-07" version="1">MADESTPAPAVVGLGASAGGVEALTSVVAGLPPSFEAAVLVVLHHSTTSYSALPAILTRAGPLPARHARDGERLVAGRVYVAPPGRHLVVEDGASRVLTGPRENGHRPSIDVLFRSVAASYGPAGAGVVLSGLLDDGTAGLAAIKQRGGRTVVQTPADAAFPDMPAAAIRGALPDAVCPAAEVYECLRGWLDAVLVSPPDGGEDDGDVDDPGEPELTEFTCPECGGALRRDERYGAWRFRCRVGHTYSATSLLTGKHDALETALWAAIVALEERRDLSRQVRDRLADQGSPPRGVARFEQDIADSERRAQLLRSVFDELVTDAPIGAPEDGDGDERAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG1</accession>
    <name>A0A7K0JTG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000528">
        <property type="protein sequence ID" value="MST33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="6">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="20943" checksum="69562D9A2B24E73B" modified="2021-04-07" version="1">MAGRYTVRAGDTLGAIAARFGTTVGRLAAFNHVANPNQIVVGQVIRIPGRGVATSSSSATPAGAASPGAGGTTTGGTTTGAAAPGAPESAQAAVAVRTALAQVGKPYQWAGAGPDSFDCSGLVMYAWEAAGVFLPHYTVSQMDDTTRIRASQLEPGDIVFYDTPSGAQPGHEAMYIGGGQVVSANNVGTDVQTQSITYDGPPVAFGRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI2</accession>
    <name>A0A7K0JTI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">lysA</name>
        <name evidence="8" type="ORF">GHK86_11065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="7">
        <location>
            <begin position="59"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="6">
        <location>
            <begin position="306"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="440" mass="45865" checksum="39E06DC2BDFC1CB5" modified="2021-04-07" version="1">MIPDPAPEAAASPAEGPLPRHLLPDTATIDGGRLAIGGVDVLDLCAEVGTPAFVYDEAHLRARCREAVAAWGEGATYASKAFWCRAMARLVAEEGLGVDVSTGGELHVALAGGVPPDRLVLHGNNKSEAELDAALRVGVGRIVVDSFDELDRLERLVPRTAGGPRPAVWLRVTPGVEAHTHEYVRTGQEDSKFGFGLASGAAAAAVDRVRSPRSPVELVGLHVHIGSQIFALASFARALEVLAAFAVPLDLPELGVGGGLGVGYVDGEPTPSMTEWAATVRAAVRAAGWPEGVRIAAEPGRAVVAAAAVTCYRVGTIKQLPGIRTYVSVDGGMSDNPRPVLYGSGYETFLPRAADAPRPRRVTVVGKHCESGDVIVRDGQLPGDVAVGDVLATPVTGAYGHSMASTYNKVPRPPVVFVAGGDARTVVRRETFDDLLALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ6</accession>
    <name>A0A7K0JTQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000563">
        <property type="protein sequence ID" value="MST33331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029771710" evidence="1">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="11916" checksum="1E62B4C204C9650E" modified="2021-04-07" version="1" fragment="single">MGLGALVCAAALALGACGSAAGGSGGSTHTASPAPVVKGTPVKGGVASYALPIGEDFSWMLPLQNEANYEDYDSNVEGGMWRPLFYAGGAGTTGINYALSIGQKPVYSQGNTVVTVNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ8</accession>
    <name>A0A7K0JTQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Murein biosynthesis integral membrane protein MurJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">murJ</name>
        <name evidence="9" type="ORF">GHK86_11390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000557">
        <property type="protein sequence ID" value="MST33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="541" mass="57289" checksum="5966B9020D70CA34" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR6</accession>
    <name>A0A7K0JTR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000567">
        <property type="protein sequence ID" value="MST33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="20674" checksum="899D085B4F21EAA1" modified="2021-04-07" version="1">WVRADVSVADDRAALIDAAIAHGGGIDLLVHAAADMYRGPLAELEEQRLVELLHGNVVAPMMLTGLALPHLVERRGCVVLFGSVHVKRAFPGASPYAASKGALETLTGVLAAELGPRGVRVSCVRPGGVFTEINQRAGLFDDETARRRIEDLGPAHALGRPGTPEEVAEAIEYLATAEWTTGAVLVVDGGLGLGTTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR9</accession>
    <name>A0A7K0JTR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000564">
        <property type="protein sequence ID" value="MST33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="17490" checksum="A335EF2C6F016E1E" modified="2021-04-07" version="1">RWAAGQGLLRLGFLRLDGRPVAFCFALRHGGTVAVPKTGFDPAFSYHAPGVLLVRRLLRSCFEDPTVTRFEFLGEAEDYKRVFTDHQEQQLRLEVLRDSPAGRARRAALGTGRRARRELASRLPIEVRERLDLSSPAGVRYSNQCGNGRRTRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU33</accession>
    <name>A0A7K0JU33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease V subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000588">
        <property type="protein sequence ID" value="MST33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="479" mass="51574" checksum="17084D7C80ED4146" modified="2021-04-07" version="1" fragment="single">DSTHRPLGDARPAGVLARIQADIRADRRPPGAGVDARLLVDAADRSLVVHACHGRTRQVEVVRDAVLHLLAADPTLEARDVIVLCPDIEAFAPLVQAVFGTDEPDGGAGRLRVRLADRSLRQTNPLLAVAATLLDLAGSRATASAVLDLAARPAVARRFHFDQADLATLEEWVVGSGIRWGLDAADRHRWRLGTVAANTWEAGLDRLLLGVAMDGPGVLWGGTVPYEDVPGGAVDLAGRFAELVTRLAASLDELRDPQPLAAWTEALTAGSELLAVAAPGDEWQHEELRRVLADTRAEAAVREATTLTLAEARALLASRLQGRPTRANFRTGDLTVCTLVPMRSVPHRVVVLLGLDDGAFPRHPEPDGDDLLLRCPEVGDRDPRTEDRQLLLDALMAATDHLVVTYAGRDERTNRVRPPAVPVAELLDVVDATFRRADGRPARESVVVEHPLHPFDERNFRAGGPGGTGPWGFDPVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU67</accession>
    <name>A0A7K0JU67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="184"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="377" mass="40017" checksum="2EDA101BCE3B6D1C" modified="2021-04-07" version="1">MSESYGFLSTYPPTECGLATFTASLVAALGEGPRPCRVGVVQVLDGEGAPRAREVVHQMDKSARGSLGAARALDRFDVAVVQHEYGIYGGRDGAAVLAVAGRVHAPMVVVLHTVLTKPTAHQRMVLEELARLASSVVVMTETAHRRLTEGYDVDPAKVEVIAHGAPTEWRTGQRRAGAAVPSMLTWGLLGPGKGIEWVLDALVELQDLSPAPHYVVAGGTHPHIAAREGEAYRAALADRASRRGIRGAVTFIDRYLPRDELHSLVQAADVVLLPYDSTDQVTSGVLIEAVTARRPVVATGFPHATDLLSTGAGIIVARQDARAIADAVRRILTEPATSASMVAAAERLAPHLTWAAVAARYRHLGARLHRPSVPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU81</accession>
    <name>A0A7K0JU81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000618">
        <property type="protein sequence ID" value="MST33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="36613" checksum="56F7C1E6C99EDC31" modified="2021-04-07" version="1">MPPADHAGPAILVEGLRKSFGSVEALRGIDFAVERGTVLGVLGPNGAGKTTAVRILTTLLRPDGGRAVIEGRDVLRDPEAVREVIGLAGQSAAIQDELTGRENLEILGRLYHLPKARARQRAQELLERFDLVDAAGRTARTYSGGMARRLDLAASLVAEPAVLFLDEPTTGLDPRSRNGMWSVIRDLVSGGTTLLLTTQYLEEADELADEIIVIDHGQIIAAGTSETLKDKVGGDVVEFGVLERDRIGDAATAVADLSDVAPMLDREEGLVTVRVGSRGSQAVVQAVRNLDAAGIETSGLALRRPSLDDVFLALTGHQAEEESGAAPPGGRGRKGARGDGAGASRGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC9</accession>
    <name>A0A7K0JUC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000510">
        <property type="protein sequence ID" value="MST33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="5624" checksum="3CC46957DD9417FD" modified="2021-04-07" version="1" fragment="single">MFARIVRHAYIERIVHSAETAFEATGADGLADRAGRAILATGQLVRRRVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD7</accession>
    <name>A0A7K0JUD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000637">
        <property type="protein sequence ID" value="MST33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="32763" checksum="E7EC5D5065AAE92B" modified="2021-04-07" version="1">MLQQWDERNRDLVVNVGGVLRHRDEAGVSPFDSVVQGGDAVWEGLRLYQGRIFALDAHLRRLRASARALAFTGIPDDATLVEEIRRTLVANDMHDGVHIRLTLTRGLKITSGMDPRLNQSGPTLIVLAEHKAPVYDRGGITLVTASVRRPAPDVLDPKIHHNNLLGSILAKLEANVAGADDALMLDQRGFLAETNATHLFFVAGGVLRTPTTVACPEGITRATVLRLARQAGGDVEEGDFTLPQLYAADEAFVTGTMGELAPVVAVDGRPIGDGRPGPVSGELARRYARLTATEGTPVVAPAGAGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN0</accession>
    <name>A0A7K0JUN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fliG</name>
        <name evidence="13" type="ORF">GHK86_13100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000673">
        <property type="protein sequence ID" value="MST33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="224"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="339" mass="35987" checksum="44C8D224E85B3215" modified="2021-04-07" version="1">MAGRGPPVSGPELTGVRKAALLLVQLGTDRAARVLQSLDDEEIEAVIAEVASLEEVDSSAGTAVLAELVQRLDRGSSPSTPGRAFARKVLTSSLDPHRASQFIDRMGTAPFRELLELPVEQAVAALAPEHPQAVAVVLSSLPAERSLALLQAFPEDRRGDVAFRMASMEPPTPEAVAAVRAGLTKRLAAASRPDGARRARERSAALVEVLQRADAELEAAILAQIQRVDPDLAAEINQKLFSFEDLARLPDKDLQLVVREVDAKVLALALKGASELLRGKLLANMSERAAASVAEESEILGAQRKSDVEAARSEVLAAMRGLEETGKITVARGDDSLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX2</accession>
    <name>A0A7K0JUX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpt</name>
        <name evidence="5" type="ORF">GHK86_13555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="WJHE01000704">
        <property type="protein sequence ID" value="MST33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="51"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="23218" checksum="C52E7B726EB6F4DF" modified="2021-04-07" version="1">MSAVAGPVDEPEPSAAPWRTGLPVARRPGCLPEPPWDDPSLGELIVPADELQARIADLGAAIARHYADRPPLLVGVLKGACIFLSDLARAIGLPVEMDFMAISSYGSATRTSGVVRIVKDLDIDLTGRHVLIVEDIVDSGLTLSFLTRNLLARNPASLEVCALLVKEGLQATSLDLAYEGFRIPPEFVVGYGLDVAERFRNLPFICEYRGGDPAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY7</accession>
    <name>A0A7K0JUY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000715">
        <property type="protein sequence ID" value="MST33761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="40249" checksum="5B05652EB08A7A37" modified="2021-04-07" version="1">MRVAAIGDAHLGRAYYPYTTEAGVNQREADFERSFEAAVDLALAEEPDVICWLGDVFDHPRPTYRSYRVAQRALARIRDHGVTLVAISGNHDTPRLPGTGSPYSTLADGFPEFHFAPGLQYRRFELPGLVVHAVPQMLTVDAALAALDEAAAARSADRTNLLLTHPRLTQLQPKHADINEIEVDKGRLQSDLVLLGHYHGFAQVDAGMWYAGSTDTFQFSDEPERAKGIVVLDTETGACRHVPLAGTRPLVTLETVFAMGLSPAELSERVLQRAAGAPAGSVARLFLEGVDPQAYRMLDLQAVREAAGAALHLKLEPQFVSVTVPAELPSVDTIGGQWDGYLGGQDLTGLDRERIRALGHRYLEAAVEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ1</accession>
    <name>A0A7K0JUZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000714">
        <property type="protein sequence ID" value="MST33758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17681" checksum="074FF368D11213B8" modified="2021-04-07" version="1">GSPPLGLPWIIDAVLARALTAGAALERAASDQPYGRQAVFRDPFGHRWMLSGARADVGRRHGDIGYASLNVPDAARAAAFYGAVLGWRYEPAAAGHARQVVGQGLHHGIWGRDGPPTLFLAFAVAGLDAALARVRDAGGTAGPAEDEPYGRIAECRDDQGTRFALLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV41</accession>
    <name>A0A7K0JV41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_13925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000734">
        <property type="protein sequence ID" value="MST33811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="29170" checksum="301A19BCC443E0B2" modified="2021-04-07" version="1">RRALRRGGVVTDVAGIKGPIAAALPEPSFVGGHPMAGSEQQGLDGADPDLFEGATWVLTPTATTDADAYATVQSVASTLGALVVAVPPERHDQLVALISHVPHLTAATLMNLAADSALEHGTLLRLAAGGFRDMTRIAAGDPGIWPDVCRDNKAAIVAALDGLIDALREVREAVGGADREGLLKHLERASEARRNLPVGAPAPRESVEVRVPVPDRPAVLAEVTTLLAEVGVNIYDIEIAHSAEGERGVLVMVVSAAAVPVAREVLTGRGYRLSVKRMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV61</accession>
    <name>A0A7K0JV61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000750">
        <property type="protein sequence ID" value="MST33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="368" mass="37406" checksum="71994C5865F5B905" modified="2021-04-07" version="1">MRLGLLDLLRARLRFGLLAGALAVLVFLLLFLNTISATLLGFLTGAVQHNSADVLVYSATSRRNLQASRLDPSVVGTIRAVPGVAAAGPIGQTTLTASVGRGLDDLSLFGYQPGRPGGPARIVSGRLPGPGEALVDRTDEPNGFRIGATIVVQPTGRRLKIVGYTEESRFNAAPTAYTTIGTFRRIVAAANPGAPIVPDNLVGVAVDQGTSPSSVADAIDAAVPGVEALPRAEAVASIPGVSSITASFDLIVGITFVIVAVVTGFFFLIITVPKLRVFAGLRALGATSRYLAASVLTQVVTVVVAGVAAATALLAAAAAMSSPAFPLAVDTRLVLLSGAAVLGSSVAASMLAVRRVARVDPLVGSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV68</accession>
    <name>A0A7K0JV68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000742">
        <property type="protein sequence ID" value="MST33838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14055" checksum="C869A967E1A07902" modified="2021-04-07" version="1">PAPTATATRPARRVSRMALLRLGATATVVGLLTGFFGVGGGFVIVPALVLALGFSMPEAVGTSLLVIGINSAASLGARLGGHVHLDWTLLAVFTLAAVAGSVAGNRVASKVNSAVLTRAFTVLLVVVAVYTAARSIPHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI3</accession>
    <name>A0A7K0JVI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000643">
        <property type="protein sequence ID" value="MST33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029726168" evidence="1">
        <location>
            <begin position="33"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="65"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="305" mass="31717" checksum="4946F90E40AE064E" modified="2021-04-07" version="1" fragment="single">MRAHATGWTGRFVAALGLAALLLAACAPTAKVIEGRRATPVAADPASPPPGLAGRQWDRIPTNAKVVALTFDAGANADGVASILATLRQQHVPATFFLTGDFVKAFPSQTRDIAAAGERVGDHSVSHPYFTQLTDAQIRAQVVDAQAQIRATAGTDPWPWFRFPYGDYDAHTIAVVNSVGFVPVGWTVDTLGWEGTSGGISVATVVSRVLAALQPGEIVLMHCGSNPTDHSTLDAAALPQVISQLRARGYRFVTVDALMGLGYTISTSDGGAHSFGAPWYGSMAGKLAPGVRVVAIAGDPATGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ4</accession>
    <name>A0A7K0JVJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000773">
        <property type="protein sequence ID" value="MST33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029674932" evidence="4">
        <location>
            <begin position="28"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="32110" checksum="9C22B3D37BBDFE89" modified="2021-04-07" version="1">MRGSPGRRLCRPRRAGTLGSVPPDAVAASGLTKRYGPQWALRGIDLSVAAGECLALLGPNGAGKTTTVEILEGYRARSAGSVRVLGVDPDRAGPAWRARIGIVLQDATDQGQLTVAEVVHHFAGYYPAPRDPEEVIAAVGLTAKRAARVAGLSGGQRRRLDVALGIVGRPELLFLDEPTTGFDAEARRDFWGLIDALRRQGTTVLLTTHYLEEAERLADRLAVIAGGRVVADDTPAGLRRGPTTVSWRAPDGRPCQRETTGPTQLVAELAAAFGGEVPQLAVHPPTLETAYLRLLAAAGEEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP1</accession>
    <name>A0A7K0JVP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">GHK86_14985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000814">
        <property type="protein sequence ID" value="MST34020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST34020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="23186" checksum="42EBA0B6FBBE99FE" modified="2021-04-07" version="1">MTPVGSPAPPAGPRLAVVDSGIGNLRSAEKALQRVGADARLVDDPSAVAAADGVVLPGVGAFGRCREALAERGLDQAVLDAVARRVPLLGICVGLQLLYEGSEESPGSAGLGVLPGVVRRLPAGVKHPQMQWNRLEVRDPACPLLSGPRLAPPAEAWVYFVHSYAAPVAPETVATCEYGGPVSAVVARDRLWATQFHPEKSGAVGLAVLAAFVAEVGRLSAIGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ6</accession>
    <name>A0A7K0JVQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="451" mass="48072" checksum="7FCA1F3D36D465EB" modified="2021-04-07" version="1">MLEPAREVEVVHETEVLVVGSGPGGLAAALASARAGATTTLLERNGCFGGNITQVGVEGLAWYRHEGTVDCEGIGIEFEQRAVEMGAASPEMQSTGYNLDAEMFKVVADRLVDESGVRPMLHRLFVRPLVEDGRVTGVITESKGGREAILARRVVDATGDADVAARAGAPTFKAPRESLMAASVMFSMAGVDKRRFIEAVRADPGTYSDWAGEGEWDIETTGKEDDLFSPFLRKPFKQAEAAGLLPPGTTTIAGTWGAVTDQGDLTYLNLVSLPGIDGTDPDDLTAGEIAGRQRALEAVEALRHFMPGCERAKLRNFGMTIGVRDTRKIDATYNLTESDVRGEGRFDDAIGIFPEFIDGYGLLVLPTTGRYFQVPYRALLPGSVDNLIVAGRCIGGDRISHAAVRNMMCCAVSGQGAGVAAAVSSRTGKAFADLDLGTVRAELRRQGVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW01</accession>
    <name>A0A7K0JW01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_15500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000858">
        <property type="protein sequence ID" value="MST34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="234" mass="26179" checksum="6BF26F153E2AD867" modified="2021-04-07" version="1">MAEPLTVLVVEDEESFVEALVIGLKREGFLVKVATDGVEALEMFDQVRPDLVLLDVWLPRLSGIDVCRELRTRSRVPIIMVTAKSSEIDTVVGLEVGADDYVTKPYRLRELVARMRAVLRRSPPAEGGAPQADALEVGELRLDPERHEVLLSGQPVVLPLKEFELLELLMGNAGRVLTRETLIDRVWGPHYVGDTKTLDVHIKRLRAKIEEDPSRPARITTIRGLGYKFEGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW38</accession>
    <name>A0A7K0JW38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000714">
        <property type="protein sequence ID" value="MST33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="17209" checksum="145DDC2B2CE40E7B" modified="2021-04-07" version="1" fragment="single">MGFDNPPVRWKELEARLSGRARQGGRGDGNDAPAWSSKRPPSTPPAALTAPRSRPVGAVPYAELHCHSNFSFLDGASHPEELVEEATRLGLEALALTDHDGLYGVVRFAEAAREVGMPTIFGAEVTLDLPAAPPGGAGVADPAGTHVVVLARDPVGYTRLARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL8</accession>
    <name>A0A7K0JWL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-sensing transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000951">
        <property type="protein sequence ID" value="MST34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="10380" checksum="EDB0339F1795A73B" modified="2021-04-07" version="1">MSEVRAVELPDEVAAEVRRRLRRVAGQVAGIERMLDDGRDCRDIATQVSAATHALEQAGLRIVAAGMKYCIENPEAAVAEGYPLDTFEKLLLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM9</accession>
    <name>A0A7K0JWM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000794">
        <property type="protein sequence ID" value="MST33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12225" checksum="9730333B57125281" modified="2021-04-07" version="1">MQGTIEVTLDYPDAGAAAAFWAAALGYERRYARPPYEVIGPPAGEDGPTLVLQQVPAPATASRVHLDLRVPDPEATVARLCRLGAAVREVVAEAGRAWTVMVDPWGTVLCVCPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN2</accession>
    <name>A0A7K0JWN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_16715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000963">
        <property type="protein sequence ID" value="MST34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="7">
        <location>
            <begin position="451"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="629" mass="64856" checksum="6C8A38E464C9F62D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN9</accession>
    <name>A0A7K0JWN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-hydroxycinnamoyl CoA hydratase/lyase</fullName>
            <ecNumber evidence="4">4.1.2.41</ecNumber>
            <ecNumber evidence="4">4.2.1.101</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.41" evidence="4"/>
    <dbReference type="EC" id="4.2.1.101" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000963">
        <property type="protein sequence ID" value="MST34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050548">
        <property type="term" value="F:trans-feruloyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="36436" checksum="598A64DC0AD72EBC" modified="2021-04-07" version="1">MLVRIRGYSPRSRRHDGRAGTVEPACRPSEERTPNVTSQQPERTWTAPEGTVRIEFEGPVAWLYFNRPEKRNAMSPTLNREMLAALDLLEGEDEARVVVLTGAGESWSAGMDLKEYFRDVEQAPPHVEVQARRDSAEWQWRRLIHYSKPTIAMVNGWCFGGAFTPLVCCDLAIAAENAVFGLSEVNWGIPPGGLVSRALAETVPSRDALWFIMTGETFDGVRAAEMRLVNEAVPAERLRERTLEVAQKLASLNLRVLRAAKVGYKKARLMSWDEAEDYLYAKLDQAVLGDPEGGKQQGLTQFLDAKTFRPGLGAYERAADAAVTEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS9</accession>
    <name>A0A7K0JWS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000816">
        <property type="protein sequence ID" value="MST34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="19819" checksum="71FB5FDF116966CD" modified="2021-04-07" version="1" fragment="single">MSLSREVPAPGDEGHDIRTGILSRRRLLQATAVGAGAVWAAPAVEALTTPAAAASAPVAPTTVTQTFTYVAGEPVQTFTVPAGVTQLDVTVVGGTGGSYENSTTAPGGAGASVSAKLLVPAGLAVLGIVVGQQGGGTVQFQVAPGAGGASAFGNGGSGGSFLYGYANGGGGASGVFTSTTPGRSTALVVAGGGGGASYANAGGAGGAPDGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT8</accession>
    <name>A0A7K0JWT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hisB</name>
        <name evidence="7" type="ORF">GHK86_14980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="WJHE01000814">
        <property type="protein sequence ID" value="MST34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21475" checksum="3046D668F5E23764" modified="2021-04-07" version="1">MSTAGRRASRSRATKETAVTVELDVDGTGRADVSTGIPFFDHMLAQLGRHGGWDLRIEATGDLTVDTHHTVEDVGITLGEALREALGDKAGVRRFASVAVPLDEALIEVALDLSGRPFLVYEVDPSPGGEAFLLGEPGFDPQLAEEFWRALTVAAALTLHLKSRSGRNTHHILEASFKAVARALRDAGRVEGAGVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX35</accession>
    <name>A0A7K0JX35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001049">
        <property type="protein sequence ID" value="MST34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="341" mass="36080" checksum="F0556725BF910F2B" modified="2021-04-07" version="1" fragment="single">MAVLEAGGNAFDAAVAAGLVLQVVEPHLNGPGGEVPVVAWAAAEQRPFVVCGQGSAPAAATIGAFGDLGLDLVPGTGLLPACVPGAFGAWMLLLERWGTLPLRDVMGYAIGYAEAGHPVLPRVAATVELLADHFRAHWPTSAAQWLPGGRPPRAGELVPNKALARTYRRVLEEAEQRSTGRDGQIEAARSIFYEGFVAEAIDRFCRGEPVLDISGGGHRGLLGGEDLARWRAGVEEPVTAGYRGLTVCKPGPWTQGPVLLQQLRLLEHFELDGWDPVSAELIHTTTECAKLAFADREAYYGDPTFVDVPLEDLLSPGYARARAALVTVTASRELRPGSPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC5</accession>
    <name>A0A7K0JXC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease III</fullName>
            <ecNumber evidence="3">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnc</name>
        <name evidence="10" type="ORF">GHK86_18005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001096">
        <property type="protein sequence ID" value="MST34608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="239" mass="25509" checksum="860FC88B8F254505" modified="2021-04-07" version="1" fragment="single">MWELAERVGWAVTDDQLLSQSLAHRSWCAENPGYDSNERLEFLGDAVLGLAVTDHVYRAYPALPEGELAKVRASLVNSAALAELASELGLGAALLLGKGEDASGGRHKSSILADAMEAVIGAVYLDRGRDAADSLVLRLLGDRIEEAAAGPGGQDYKTRLQELCSRRFDQLPEYRVRDHGPDHAKHFDAVVSIGGEVRGRGRGRSKKQAEQAAAREAWEALAEAEAADDGPAAVGAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC9</accession>
    <name>A0A7K0JXC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl carrier protein</fullName>
            <shortName evidence="8">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpP</name>
        <name evidence="11" type="ORF">GHK86_18000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001096">
        <property type="protein sequence ID" value="MST34607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 8 9" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8 9">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST34607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10477" checksum="EC4113F3992ABA87" modified="2021-04-07" version="1">MPAETHVEGSKPDRAGVLELVRNSLAEILEVEPSAISEGSSFDDLGADSLALIELVEALEEELGERTVGFHIDDEDLEDLKTVRDAVDYVTAKLGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP9</accession>
    <name>A0A7K0JXP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000935">
        <property type="protein sequence ID" value="MST34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="37612" checksum="FEDA1503F4A56690" modified="2021-04-07" version="1">CSHPAHVRRTGFGRIEGEELVRASRQEWHRAVAFELLERHRPGPGGRDGGSPAGRADGEGEAFPTPAEQSERERIAELEVRAFYESRDLLTQPSWLRHYRFQPRPPYLEPLAWLGVTDDLTGPDRLGDNAVSYVPTGPGPLPYFYRANAADPRAGIAHEGAHYQQLALAWAGARPLRRHYVDSVPNEGIAFYNEEMLLQAGLWADAPATRAVIYNFLRLRALRVEVDLGLALGRLSIGEAGRILAGRVPMDEGTAREEAAFFASTPGQGMSYLVGKQQVLALLADDRLARGEAFSLREFHDWLWTNGNVPIALLRWERLGDHSQLDRIDAWRAVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR2</accession>
    <name>A0A7K0JXR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system death-on-curing family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001184">
        <property type="protein sequence ID" value="MST34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9670" checksum="EFCCC8B3D6422F45" modified="2021-04-07" version="1" fragment="single">RYLALDDYLAIAVEVTGQRVATIVGAADHALADSALHAPMAGFSGRELYPDFVDKAAVLIVRLAKNHPLPDGNKRAAWASLRVFVALNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS6</accession>
    <name>A0A7K0JXS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001194">
        <property type="protein sequence ID" value="MST34750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="10679" checksum="ED9964E27AF7A24B" modified="2021-04-07" version="1" fragment="single">MVADDCIVGTDALIHPGVAVYPGKTVDAGASVDSSIVWETRRPRSVLGAAGVTGLANLDVTPELAVRLAMAFASTIRRGGRVMVSRDTSRVGRMLARAVMAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU8</accession>
    <name>A0A7K0JXU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_18530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001170">
        <property type="protein sequence ID" value="MST34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="84"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="27245" checksum="7C012569540295ED" modified="2021-04-07" version="1" fragment="single">MWRFGLAEGPVAAYERVVRTEGPAPGAPTGRVEVRQDVRFRVGIPYVAWLFALPLLANLGGLVPGGRAPWWAPPQRMTHAQGVALAGLCGFAVLAGYLGGLLPATATYIGRQYHVGDAGQGYALAGVQVGAILALGVLVAADRRGRRWSVIATTVAGALVSLAAAAAPSLATVALTQVAATALLTAQYVLLGVMVVELMPAGGRAWALGLLTMSYGLGGGVTLAVLPLAGLGAGGWRWLYALAGLAVLGAAGLARHLPETERWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV7</accession>
    <name>A0A7K0JXV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">GHK86_18585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="WJHE01001176">
        <property type="protein sequence ID" value="MST34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="26772" checksum="886A50AAF2CE1BAE" modified="2021-04-07" version="1">VGADHHVHRAVGEPVGDLAGLVTGAAVAPGVTTEELDAIAHAAYLERGAYPSTLNYHGYPKSICTSVNEVICHGIPDDRPLADGDIVNIDVTAFLDGVHGDCSAMFLVGDVDEESRRLVEVTRECRDLGIAAVRPGRPVSDIGRAIEDHAHAHGYGVVQAFIGHGIGETFHTQPSIPHYFNPEARTVLEPGMIFTVEPMITLGSWREKMWDNGWTAVTADGRRTAQFEHTLVVTDAGAEVLTPEPDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX8</accession>
    <name>A0A7K0JXX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001236">
        <property type="protein sequence ID" value="MST34821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="20078" checksum="5B505A95BE77DC0C" modified="2021-04-07" version="1" fragment="single">MPSGPQSAPTVPALETTVLTKAYGDLVALAPLDLTIPDGQRVVLVGHNGSGKTTLLRMVAGLLEPSDGRALVFGHPAGSLEARAALSYLPDNPVLYDDLSVLEHVEYTCRLHGAEDWEERAVGLLADLGLTQRADDLPSRFSRGLRQKTAIVLGLVRPFGLLLVDEPFVGLDPSGREAFIELMDDAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF3</accession>
    <name>A0A7K0JYF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannitol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001346">
        <property type="protein sequence ID" value="MST34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023027">
        <property type="entry name" value="Mannitol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00974">
        <property type="entry name" value="MANNITOL_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh_C" evidence="1">
        <location>
            <begin position="69"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="345" mass="37075" checksum="CF2DFC23699C1EF5" modified="2021-04-07" version="1">LAADLAGRPPRTTVGQLTAGLRARRRAGAGPVTVVSCDNLADNGATVGRLVRDFAARAGDEELLAWMADHVRFPSTMVDRIVPATTDADRAEVAALLGVTDEGTVVAERYCHWVIEDDFAGPRPAWEQAGVVLTADARPWERAKVRLLNGSHSTIAYLGQLAGWALMSEAVRRAPIGEVVRRLMADDVVPTLDPPPPGLDLGGYQDQLLERFANRALPHRTAQVAMDGSQKLPQRLFGTIVDRRRQGAEPLPALLCLAAWMRFIADRRDDSGRPLSVDDPLADDIARRVAGAGTAAAVVDALLGMRAVFDPELADDAVVRDRLGELLHRLRLDGAEATAAFVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM2</accession>
    <name>A0A7K0JYM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001370">
        <property type="protein sequence ID" value="MST35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="15537" checksum="9EC4E5ADB63B0FF6" modified="2021-04-07" version="1">MVSAPLVARMRPRRPLVVALGVGGLEALVALAFGAHLPLAVVAVAAGVQGVSVLVFESLWQTAIQRHVPADRLSRASSYDWFGSLVAYPVGLAVAGPVADAVGAGRTLVVMGVLMLLLSAGLLSLRSVRGLRDGPGGSDEPGEVAPAGGVAGPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS2</accession>
    <name>A0A7K0JYS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001439">
        <property type="protein sequence ID" value="MST35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15039" checksum="45CA199D2940593A" modified="2021-04-07" version="1">MCSYCGCEAEPAVRALMAEHDRIADLAYRARAASAGGDPQAAALLAEVAAAFADHSRGEEVGLFAQLRLAGEGVAEVDELEAQHRRLRAALADPNLAGRPTDLVAVLAELTEHAEREDDDLFPFALQRLPDESWSALARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ11</accession>
    <name>A0A7K0JZ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001212">
        <property type="protein sequence ID" value="MST34784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="11233" checksum="A34251619ACEF8A7" modified="2021-04-07" version="1" fragment="single">MSREHVPPSGTGRMVRLRTVTSPFHARVLVARLGADGIVTELRGNVGGPYPVGETSVWVPEEEAEVARALLLADEVEATFLGLDHGDPAPLGRPAAGRDGRRVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ23</accession>
    <name>A0A7K0JZ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001514">
        <property type="protein sequence ID" value="MST35200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="79"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="224" mass="23950" checksum="4161FA3EC8160E20" modified="2021-04-07" version="1" fragment="single">MALGALPFDRDAPAELVLPRALVTWDGQRAWLTTVEGGDDGSDAEQLGSEAASAALDPPADRGPRAPDGFDLRSARPHDEWCRVVADTVERIRGGAFGKVVLARRVDVVANGPLPTGQILERLAALYPACMVFRVGGFLGASPELLVRRRGDTVASHPLAGTVARSGDAAADRSLVEGLLASAKDRAEHAFVIDDLRARLQPWCAELRVPERPSVLELRNVSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ33</accession>
    <name>A0A7K0JZ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001532">
        <property type="protein sequence ID" value="MST35225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036622">
        <property type="entry name" value="LigA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="13783" checksum="2FB2BC3AE63576B9" modified="2021-04-07" version="1">MSKYLLDKFLYTVDRDPALVERYRSDPAGTVSWWEANLANRLLNCPADEGSTWQALTDEERRALREHDHVALFEMGAHPFLTLTLFIALFERDHGPLEYQRAYARAMAHLSLPYPDITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA1</accession>
    <name>A0A7K0JZA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ClpX-type ZB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001533">
        <property type="protein sequence ID" value="MST35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="14714" checksum="3E06C6E0F51F3A3F" modified="2021-04-07" version="1">MPRTASPEAMCCSFCTKSQSEVGKLVAGPGVFICNECIDLCNQIIAQETEGGNGSSQPASRPEASETPPPLKAWETLSDDELLGEMVRAHGAHRNVDRAVGRHVAALRERGVSWARIGDALDMTRQSAWERFSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB2</accession>
    <name>A0A7K0JZB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal peptidase II</fullName>
            <ecNumber evidence="9">3.4.23.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lspA</name>
        <name evidence="9" type="ORF">GHK86_21595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01001608">
        <property type="protein sequence ID" value="MST35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="21232" checksum="FE948046898E1BCE" modified="2021-04-07" version="1" fragment="single">MSSDPRPSTPEAPARRRAGRTGPLGVLTAVVAAVVIAVDQLTKSWALHHTAPPRHVAGPLWLELTFNPGAAFGLGKGVTPVVETAVIILVAILLLGARRSARRGDRLEALALGLLVGGALGNLADRLFRHLPGHPGAVIDWIEVAQVGRHQYWPVFNLADASIVVGAIVLAWRLSVRPARHRATGPSAEPAGGEGGVGSAGGVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE3</accession>
    <name>A0A7K0JZE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-phospho-L-lactate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001630">
        <property type="protein sequence ID" value="MST35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="12853" checksum="EBFC1A3F2D361189" modified="2021-04-07" version="1" fragment="single">VTAVVNTGDDVVLHGLHISPDVDTVVYTLGGAANPDTGWGRLGETWEAMAELRALSGGRLAWFNLGDRDLGTHLYRTTRLAEGAGLGEVTAEIARRWGVAVRVLPMSDDRVETRVAVAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE9</accession>
    <name>A0A7K0JZE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
            <ecNumber evidence="2">2.5.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folP</name>
        <name evidence="2" type="ORF">GHK86_21575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001604">
        <property type="protein sequence ID" value="MST35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="21657" checksum="8EA3CAA4E3277CAE" modified="2021-04-07" version="1">VSEAEELDRVVPAVAALHERFGVPLSVDTWRAGVAAAAYRAGAVMGNDISGFADPDYLPAAAEAGAAVVATHIRLSPRVPDPEPHYDDVVEDVRRYLAERVERARAAGIGDDRIVVDAGLDLGKTTPHSLQLLAGSARLADLGVPLLLSASNKGFLGEAFGLAIGERQMASTAAHAVGVSLGCRILRVHDVAAARRVRDTLAAVLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI8</accession>
    <name>A0A7K0JZI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001618">
        <property type="protein sequence ID" value="MST35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="7347" checksum="1F826D8D7E00BBAF" modified="2021-04-07" version="1" fragment="single">ADGVVTVTLDRPERKNALTHREWGRLQEVFGEVAERPEDRVLVVTGAGGDFCSGADVSAFGDDERSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZL5</accession>
    <name>A0A7K0JZL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001671">
        <property type="protein sequence ID" value="MST35367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="7963" checksum="6855DFE18D7DB75E" modified="2021-04-07" version="1">CLELWTRKEAYLKATGAGLSITPRSVEVAAPAGQPARIGAWAVHQLDAGPGVAAAVAVPDRQPPIPVPALAPLRAHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0H0</accession>
    <name>A0A7K0K0H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001567">
        <property type="protein sequence ID" value="MST35269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14731" checksum="72BB23FFB4C2498A" modified="2021-04-07" version="1">MGVLLARRRAAGSLREVDDAERSDPGSGATGTDLPVVYWRPGCFFCNRLLRAFDRAGVRFERRNIWEDDEARAFVRAHNRGDETVPTVAFGGDVQTNPDPRRYVAQLAAERPDLVEAVEEGPGGRLSSLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0M9</accession>
    <name>A0A7K0K0M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalt ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001640">
        <property type="protein sequence ID" value="MST35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8442" checksum="9B76EEDC4D00D3DB" modified="2021-04-07" version="1" fragment="single">AGRVTVAGRDTRSHPPRELADVVGVVGQDPRAGFVTDTVEDELAYGMEQLALPADTMRKRVEETLDVLGIAPLRDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW0</accession>
    <name>A0A7K0JMW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="3" type="ORF">GHK86_00480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000018">
        <property type="protein sequence ID" value="MST31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="28895" checksum="3D52A70170DEAE7F" modified="2021-04-07" version="1">MTLPMFRPEDDPGPDFAGVLRRCGLEPFGGMARGAAAGATPVPPFEDRHGTTIVAIRYADGVVMAGDRRATAGSSIAHRAMEKVYPADRHSGVAIAGSAGPAMEMVRLFQLQLEHYEKVEGQALSLEGKANQLSQMVRGHLGMAMQGFVVVPLFAGYDLRRAAGRIYTYDPTGGRYEETDFHADGSGGRDARTTIKLGWRADLDRTATIELAVRALWQAADEDSATGGPDAVRGIYPTVATITADGYEPVPEAEVAAGFASVLDALEGGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX0</accession>
    <name>A0A7K0JMX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000036">
        <property type="protein sequence ID" value="MST31312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="782" mass="82725" checksum="B4BA4FCCC9156CAA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN18</accession>
    <name>A0A7K0JN18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000046">
        <property type="protein sequence ID" value="MST31362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="23107" checksum="94BFE2F9BA17C4F0" modified="2021-04-07" version="1">FRGPNGVWTRNPRAERTSILADYLADPRVRAQAWRNRLTSPVWAARPNRGHRALLEPERQGRLRALLTQNVDGLHQQAGSSPAVVVELHGSLRGVRCRGCGAGGPMTAVLDRVRAGEVDPRCTDCGGILTSTTVSFGERLDPDVVRRARDAALDCDVLLAVGSTLTVKPAAALVPLAKRSGAAIVIVNGEATPYDAVADAVVRGSISDLLPRLLATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN71</accession>
    <name>A0A7K0JN71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="26561" checksum="156EED7A47DFD0C0" modified="2021-04-07" version="1">MNVVVCAKQIPDPANPGQLSPDTHTLVREGKLILDDSDAYGVEVGLQLAEAAGGEVTLVSMAPHGETSGLRTALAMGAARAILVSDEALAGSDALSTAKVLAAAVRRAEPDLVIAATESTDGYTGTLPVQLAELLGLPSVSFAKRLELAGGVVHADRQTETGYDEVEVALPALVTVTAGVVEPRYPSFKGIMAAKNKPIEQLTLADLGIDPASVGAAGARQEVVSVVAAEARQAGEIVIDEGDAHERIVAFLEQLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNB4</accession>
    <name>A0A7K0JNB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000047">
        <property type="protein sequence ID" value="MST31367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="14724" checksum="4DFF2128B8F2E473" modified="2021-04-07" version="1">MDRRPSGRIPMTDTDAATTKDTVRRYYAILGAGAAGFDPDRLRAVLAPDLVFEGPIAGHRVGAEPFIAGAAGFVRAARRIDLLHQLHVGEEAAALYDAELPGGAVRFAEFFRVGDGRIRSLRLLYDAAEFRARGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG0</accession>
    <name>A0A7K0JNG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000068">
        <property type="protein sequence ID" value="MST31443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="53"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="433" mass="45376" checksum="6856B673DA07CCDE" modified="2021-04-07" version="1" fragment="single">MAEGQAAKVAARVASASSGSGQRRHPSRRGPSSQEVPECVVSTFEARAHPEGFVGRQRELADLDRLLDAAREGRSGARVLHGPPGVGKTALLERCAARAVGFRTIRVTGAQSERDLAFAALHQFCSPVLDQLDQLPAPQRQALEVTFGMSEGAAPDRFFAGLAVLGLVSKASEAGPLLFVVDDAHWLDQSSARILAFVARRLAAEPVAVLFATREAGGDLEGLPELVLTGLAPEDARQLLRSALPGPLDEAVATQLLAETQGNPLALLELPRGLSAGRWAGGYGLPAALSPTEQVEESFLRRARELPGDSRRLLLLAATDPAAPVEVIRAAAAALGIGDAAVAAAVGSGLVEVGSTVRFRHPLVRSVLYRDASVDERRQVHRALADATDPATDPDRRAWHLGRSVAGPDDEASSTPAGVDPPVRGAGRSAHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH9</accession>
    <name>A0A7K0JNH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chlorite dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000071">
        <property type="protein sequence ID" value="MST31463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="25404" checksum="3BDED1EF8F02BA6E" modified="2021-04-07" version="1">MSERLAPSEGLGVLHLFCKIRPGTDAEAVVAAVKSGRDDEHQAVCFSVFGHKADLGVLALGPDWVQLRRLQARLQAAGLDVVDSYVSLTEVSEYARASVEKQKLSPRLYPKLPPEGKRAFCFYPMSKRRGEQDNWFRLDFDQRRDLMLEHGTSGRRFAGRVLQLVTGSAGLDDYEWGVTLFAVHPDDLKECVYTMRFDEASARYAEFGPFYAGIVGEVEEVVAQVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK3</accession>
    <name>A0A7K0JNK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA-acylating methylmalonate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mmsA</name>
        <name evidence="5" type="ORF">GHK86_01620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="493" mass="51831" checksum="F505A27A67DBAD7A" modified="2021-04-07" version="1">MRSINHWIGGKSIPGGSGRHGTVFDPATGTVQAEVAFASVEEVDQAVAVADEAFGSWRSTSLSRRSEVLFNFRQLLHDRGSEVVDAISAEHGKVRSDAAGELARGLENVEFACGIPSLLKGEFSEQASTGVDVYSIRQPLGVVAGITPFNFPAMVPLWMCANAIACGNTFVLKPSEKDPSASLVLAELFAEAGLPEGVFNVVQGDKVAVDRLLEHPQVAAISFVGSTPVAREIYRRGTDAGKRVQALGGAKNHMVVLPDADVGLAADAAVSAGYGSSGERCMAVSVVVAVGAVADPLVEAIAERATRVKVGPASDPDAEIGPLISAEHRDRVRGYVAGATAEGAEVVLDGGDAGGDGYFFGPSLLDRVQPGTRAYEDEIFGPVLSVTRVDSYAEAVRLVNDNPYGNGTAIFTRDGGAARRFQFEAKCGMVGINVPIPVPVAYYSFGGWKASLFGDRHIYGPEGVDFYTQGKVVTARWPDPATSSVDLGFPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS7</accession>
    <name>A0A7K0JNS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbamoyl-phosphate synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">carB</name>
        <name evidence="11" type="ORF">GHK86_02515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000104">
        <property type="protein sequence ID" value="MST31605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="682"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="989" mass="105169" checksum="AB7D79DECFF9FC34" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ4</accession>
    <name>A0A7K0JNZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000116">
        <property type="protein sequence ID" value="MST31686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8554" checksum="7600E856D988BEE4" modified="2021-04-07" version="1" fragment="single">MTPTFADLGLPEALVTTLARQGITEPFPIQAATLRDALAGRDLCGKAPTGSGKTLGFGLPLLAGLAAAERWSEPGRPQALILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP12</accession>
    <name>A0A7K0JP12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000121">
        <property type="protein sequence ID" value="MST31712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="14506" checksum="58BD5C51C0A4E19E" modified="2021-04-07" version="1">NVEAVFALTVALLPALRAAASPDDPSRVVTVGSVDGIVVPGTENYAYAASKAAVHQLTRVLAARLAAESITVNAVAPGPFDSRMMAWALDDPGTRQRIAASVPLGRVGRPDDMAGVALWLASRAGSYVTGAVIPVDGGITAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP18</accession>
    <name>A0A7K0JP18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000034">
        <property type="protein sequence ID" value="MST31304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="415" mass="46145" checksum="2EFCA2BB097FC2F2" modified="2021-04-07" version="1">MNGGNLTGGVMSGKRAPVEDFATDFDHTDPTWVADPYAIWADLRGRCPVAHTDRYGGAWLPVRHAEVAAVAYDTEHFTSRSVVMSEVRPGPHDLPAPIGLAPPITSDPPFHALARRMLLPAFSPKAVAAYEPYSRRLCRELLDAVDGADEVDASVDFARHIPLRVIVRMLGFPEEDADVFRTFITGVLEDVDESAEERQARADEAVMEQYMDARIAEHLAEPRDDLTSFLLEAELDGHKLQTDHVRGTMVLLLIAGIDTTWSAIGSSLWHLATHPEDRRRLAADPALMDTAVEELLRAYAPVTMARLVAKDVELGGRQLKEGDWLLLPFPAANRDPAMFPDADRVVLDRQVNRHAAFGLGIHRCLGSNLARMELRVALEEWLARFPDFELADPDRITWSAGQIRGPRVLPLRILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP87</accession>
    <name>A0A7K0JP87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_S24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000121">
        <property type="protein sequence ID" value="MST31707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="3">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="274" mass="29330" checksum="3535E5DF0D6C67CE" modified="2021-04-07" version="1">MEVALRAEHVRTERPPSRRRTGRIVRRVLLVAVVAGWWFTLAPRVIGGPTTWTVVSGTSMLPRYHTGDLVVARRQPSYHLGETVIASVDGGHIVHQLHSGNARTGWHTKGINKNTPDLWTIPNRDVLGEAWFMIPGAGTDLRWLGTATGRILVAALLAVFVAAWPRKRRPARVTGEAEPRRGVALDVLLVTTSVGAVAAVAAWMASGAAGQASATVLGVPTLALGIVALTLLSPSLPLLAYVGLKELARTRAARTTPRHLRQSAGEPAEAPQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB1</accession>
    <name>A0A7K0JPB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03620 family F420-dependent LLM class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000141">
        <property type="protein sequence ID" value="MST31810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="31954" checksum="C2522CC020D7E59E" modified="2021-04-07" version="1" fragment="single">MQITPFALPRLGLWTGSLDAVPLAEACELAAEVERLGYGALWVPEVAGRDVFVALGAMLGATTRLVGATGIASIWARDAVTMTGGVKALTEAYPERMLLGLGVSHHTLVEELRGHEYRRPLAAMRAYLEAMDAAPYTGFRPGTPVRRVLAALGPRMLALAAERTEGAHTYFVTPEHTATARAALGDRLLCVEQAVLLEPDPARAREIGRAHTKVYVRLPNYQNNLRRLGFDDADFAAGGSDRLVDAIVAWGDEAAVAGRVRAQLDAGADHVCVQPLAAEARSVPAGQWRHLAPALREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG4</accession>
    <name>A0A7K0JPG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000157">
        <property type="protein sequence ID" value="MST31862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="8"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="33960" checksum="4F3C9A25F9438C33" modified="2021-04-07" version="1">MPTDGLVAVNVYAVEDGERLVLIDGGWAVPEARARLDRALADLDADVRAVSRILVTHAHRDHYTLAVQLRREVGTPIGLGAGERPALLALTEQWQGSLRAQRDVLRAAGAEPLLRELEALGGSQGPPDGYEPPDEWLEPGRIELAERTLEVVATPGHTQGHVVFRDPDAGVLFAGDHVLPHITPSIGFEPVPMVSPLRDFLASLDALRRLPDTVLLPAHGGPAPSVHGRIDELVAHHDARLAEMRAAVGALGGATAFEVAAGVGWTRRQRRFAELDVFNRMLAVTETVAHLTVLVDTGAVVRSGDEPVRYAPAPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU2</accession>
    <name>A0A7K0JPU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="30595" checksum="E876A8B6314C380B" modified="2021-04-07" version="1">MYNAIIGAVNGVLSADRLLEGLDNDLAALFRPDGEVSIARLLRLPTLLMPEIGDTRAPQVARVGNVVSLTHSGRDIHFRFVKSITIPDLPSDRIAQAATQLGFGRHGFTRTRWTVKQADLYQVLLEAQILDLPRPTVFELPATPPDRNMIAVMMPFAAEFSPVWQTLKSAVDDGGWLCQRASDIWDNSVLVNDIVGLIARSKVVICDLSGRNANVFYEAGIAHTLGREVVLIAQSHDDVPFDLRHHRYIVYLHNSEGLNELRRSLASRLRTLMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ4</accession>
    <name>A0A7K0JPZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6602" checksum="F0DB2A26927A35BD" modified="2021-04-07" version="1">MDVRDALLGGQYGYAAAARPDGDYVGAVIGAGLPHHDPSTRCPMIEPADPTGRQLWACLGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ06</accession>
    <name>A0A7K0JQ06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="491"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="634" mass="69485" checksum="39648E8AC18FEA41" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ13</accession>
    <name>A0A7K0JQ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="125"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="551"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="624" mass="66744" checksum="21364ACF8A7AF55B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ96</accession>
    <name>A0A7K0JQ96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="8219" checksum="710616B7D02B41DC" modified="2021-04-07" version="1">MEAQPWFAFLDRHHYIHHVDLGANLNFLLPLADYLFGTLRVELTPEELARHGPLEAAKARPVGEGGRARSDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC4</accession>
    <name>A0A7K0JQC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="55" mass="5912" checksum="2AECD3206703CDEB" modified="2021-04-07" version="1">MTPPSPPRHPATVPRATPPKAVVALLWGLRVLVIVLTVIVTWSFVAELGHPLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG8</accession>
    <name>A0A7K0JQG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000223">
        <property type="protein sequence ID" value="MST32147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="58" mass="6715" checksum="D71947614F748457" modified="2021-04-07" version="1">MLLFCRERDDGDFGAQPYFLLGPGRYVTHTGSRPMAITWTLDHRRPTSSRRPRCSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN5</accession>
    <name>A0A7K0JQN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_04000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000166">
        <property type="protein sequence ID" value="MST31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="18703" checksum="2E26516A71F706C0" modified="2021-04-07" version="1">MKAEDHFHDFAAGRSASLHRSAYLLCGDWYLADDLVQETLAKAYRHWPRVLRADSPEAYVQRILVNEVRNHWRRQNRTPPSVTGDAPEEAVPDGSETVARNDELVRALLELPVRQRATLVLRYLDGLSERETAMVLGCSEGTVKSQTSRALTTLKTHIQREEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP6</accession>
    <name>A0A7K0JQP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ORF">GHK86_05875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000257">
        <property type="protein sequence ID" value="MST32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="223"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="345"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="418"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="495" mass="52415" checksum="C02C5F328580DCF2" modified="2021-04-07" version="1">MTVRGRSTRKATRVHDGRRAAPVQLVEETPWRWRIDRAGDMRVPGIVFASRQLLPTVAADQSLQQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVADNGAVSPGGVGFDISCGVRLLVTPLDRAELGPRLAALMDQLELLIPKGMGKGAVWEPAGDAELRRVLTEGARYAVERGHGTARDLERCEDEGVLAGADPDAVSERAKLRGLHQIGSLGSGNHFLEVQVVDRVYDENVAVAFGLHPGQVCVMIHSGSRGLGHQVCSDHVGRMEAAMGRYGIHVPDRQLACVPVRSPEGEAYLAAMAAAANYGRANRQLLGEAARRAFARAVGTDRLEMLYDVSHNLAKLETHQVGGRPCLLCVHRKGATRALPPGHPDLPPALGPVGQPVLVPGSMGTASHVLAGDPGGEAFHSTCHGAGRLVSRTVARHRVSGSALRRQLARAGVEVRAGSDRGLAEEAPTSYKDVDAVVETVELAGLARRVARLVPVGVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP7</accession>
    <name>A0A7K0JQP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000260">
        <property type="protein sequence ID" value="MST32270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="55"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="315"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="404" mass="43196" checksum="9F21291127F16DA5" modified="2021-04-07" version="1" fragment="single">PPGPPAARRAGSAPSRLRPDPRRCHDVTVPYHRVRDAAKLHALLDAVLVIESDLDLLPLLRRIVRAAVDLVGARYGALGVLSPSGKGLSEFVYEGMDDELVRTIGHLPEGRGILGLLITHPEAIRLDDLTAHPAAVGFPAGHPPMASFLGMPVRLRDRVFGNLYLTEKIGGGPFTEEDEQLASALATAAGLAIENARLHARVRQLSLTEDRERIARDLHDTVIQRIFAVALSLQAVEARAAVDAHLADRLRYAVDDLDETIRQIRTTIFALEPPPTAVAQLRSEALAVCTEARRSLGFEPELRFDGAVDAVPPSIGGDALATLREALSNVARHARASRVTVSLVATDGALTVSVVDDGVGYQPLEGGNGLPNMAQRAEALGGRFHVAARPGGGTELEWRVPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ5</accession>
    <name>A0A7K0JQQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_04100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000172">
        <property type="protein sequence ID" value="MST31909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="589"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1065" mass="109803" checksum="7A64B2918ABF0093" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR3</accession>
    <name>A0A7K0JQR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7919" checksum="E9694064BD2CA26D" modified="2021-04-07" version="1">MYTHWAMQAMMIHQQQERLEAAARRRASWARGPARRRRPRWSTDLRLPVVLRPSPPAPITSAGPSGAGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT8</accession>
    <name>A0A7K0JQT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000269">
        <property type="protein sequence ID" value="MST32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="458" mass="47800" checksum="B7EF7DF4413B0751" modified="2021-04-07" version="1">MLRSARDPAGCSGRLRGAADRGRGPPLTERVEVVVIGAGFAGLRAARDCADAGVATVVVEARDRLGGRTWTRPYEPTGDLVEVGGAYFLHTHDQVAAELRRHGLGARRCAPPGGFRWHTAGVTRAGLPVPVGEWEELERVVRAVARDVDDYAAGAAPEVAALSLAEYFDRLAAPPAVRDFLFGWSVTSVGAPETSGCVADGLSSLADHGGLLGYARILEQVPVPGWGALAAAMAATPDLQVRLAAPVTKVAAHGRRFRVTTAHGDLDASRVVVAVPVNTLPHLTLDLDVPPGIDAVAGANTGAAVKLVLRAAGVPPGVWGVGRGHGLGQLVWDRQDDGVAWLVGFGARDPAVDLDRPEQVRRAVASYFPEATVLDSTWHDWNADVWSRGTWFTARPGRPPAPAPAADPRAGVQFAGSDLAGRHQGWIEGALLSGAQAAARILHQLGVADLPAAAPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU0</accession>
    <name>A0A7K0JQU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="551" mass="57899" checksum="3BC6DB5E3B7EB4E9" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV7</accession>
    <name>A0A7K0JQV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">katG</name>
        <name evidence="12" type="ORF">GHK86_06135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="WJHE01000265">
        <property type="protein sequence ID" value="MST32301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="132"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)" evidence="8">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="732" mass="80199" checksum="466ED93235DB4402" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR15</accession>
    <name>A0A7K0JR15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000279">
        <property type="protein sequence ID" value="MST32365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="21147" checksum="F307C1CAB8D6BBF9" modified="2021-04-07" version="1">MDGVDHDRHPGGRGAPRPARPHVGDGRHEKEDGVDGDGVVDRELSFAGPPALGGAEDAGSNRIKKPVRYVPDRVEAAVLDIGRRNEFPTRIVPRAHSRGAVAGSHCVNELAGRRLQDGDNVAVATGAVLSDPVPGPGHAKTFEKIDLDPFIEQTTVVHSVRAGYAAFLDPARVLDAKRIITAGEPHSAGTQHGFTYNAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR40</accession>
    <name>A0A7K0JR40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched chain amino acid aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000286">
        <property type="protein sequence ID" value="MST32400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="14011" checksum="6463F4C8DF8E2D43" modified="2021-04-07" version="1" fragment="single">MTAIERQLRAERVPAAERARLLEDPGFGRVFSEHMVTASFDRSAGWHGAAVVPFGPLALSPASAVLHYAQAVFEGLKAYAQPDGSVAVFRPAANAARFADSARRLAIPPLPEDLFVAAIEELVAVDRDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR56</accession>
    <name>A0A7K0JR56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilT/PilU family type 4a pilus ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="365" mass="39636" checksum="9409D36AC0F17FAC" modified="2021-04-07" version="1">MLCSVLDLQQLLSHVTEVGGSDLHVKAGSPPRVRVNGDLRPTPFSVVSPKDIEDVIRTMLPTEKLEEFLKTGEADFSLSVASLGRFRGNAFRQRGSGAMVLRRVLPAALSAVDLGLPPIVSRLAEELRGMVLVTGPTGSGKTTTLAAMIDHINQTRAANIITIEDPIEILHPDKRSIVCQREIGNDTRDYVQAMRRVLRQDPDVILIGEMRDIETVSAALTAAETGHLVLSTLHTTNATETINRIVDFFPPFQQHQVRMTLASVLRGVVSQRLVARADGEGRVPAIEAMVVTGTIADRIIDPGPHNESIEDLIADGEYHGMQTFDQSLFHLYKSGLVTLRAALSAATNPHDFRLALQNAGLLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB6</accession>
    <name>A0A7K0JRB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">GHK86_06950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000298">
        <property type="protein sequence ID" value="MST32457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="193"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="51762" checksum="08848066DEAF5AA7" modified="2021-04-07" version="1">MVDRRLVPPPTVIVLFGATGDLSHRLVLPALFRLAQQGLLPEDWRLVGNGRGDVAHEDFQERVRESLEEFGPKPSDGPWEAFRSRLRFAGGGFEAADPGSLLDVLEEARDELGGEAQYVHYLAVPPTAFAKLTEGLGEHDLVKGSRVVFEKPFGTSMASFQQLDRAAHAVFEEPQIYRIDHFLGKEAAQNIHVLRFANGLFARAWDRHHIHSVQIDVPETLDVSTRADFYEHTGAILDMLVTHLFQIAAEVAMEPCESLDAECIAAAREEVIGCFRKLSWDDVVVGQYEGYRQLDGVAPDSRTETFVAARMWVDNERWEGVPFLLRTGKCMAESHQRVTIRFRPPARGLDGAPPLGNCLAFELSGDGEIDLSLVAKQPGVTLTLGRAMTKLPLGKAFHTPSLPAYSRLIHDVLVGDRSLFTRPDGLAHVWEVAGDLLTDKPEPAVYAPGSWGPEAAQALAGPEGWILQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK8</accession>
    <name>A0A7K0JRK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IIB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000331">
        <property type="protein sequence ID" value="MST32565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="32397" checksum="784E66CAABDC86F7" modified="2021-04-07" version="1">MVSCTPPWTPPSPSSPPGSPGAPGSLPAVRSDGISASWWDGIAPERVRVVATDLDGTLLSPGGTVSSRTAQAVAAARAAGIHVLPVTGRPPQSLWDLATTAGLGPLGICSNGAVVVDLEEQSVVEVDHLPGELAAELVHRSRRVEPEIRFAVDNLESFTHETTFFEHTVDWDEVVYETDDLTPVLATGCLKLIARRPGLSAAELIARLEPVLGPAVHLTTSGLDWVDIGAVGITKATALARVCSRLGAGAPEVVAVGDNHNDLTMLAWAGRGLAMANAAEVIRTSADAVLPGNHDEGVAVLLERLAAARTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN0</accession>
    <name>A0A7K0JRN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000341">
        <property type="protein sequence ID" value="MST32608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="229"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="436" mass="47457" checksum="431E4D266F72605C" modified="2021-04-07" version="1" fragment="single">MGAGGHYRPRPMHGRIALVPPRFGPGVVGGSEAVSQEIAVGLASRGWDVEVLTTCATNHYTWENALPAGATFERDLVVRRFPIVPQWSEAARRAQLQIQDGRVPSLDEQVTWLGWRFTVPALYEHLLRRGHEYDAFLFSPYLFWTTTVCLPAVADRAISIPCLHDETYAHLDVARPVLADAARVWFLSEPEHQLAHRLTTLPAAHTVTGAGVDVPRRYEPERFRARYGLHRPFLAYIARREPEKGWNWLLEMYQQIRAAGGPDVDLVTAGVGDISVPDDLRGRVVDLGRISDEERNDCMAAALAYVQPSRMESFSRTTMEAWLAGTPVLAVEDGEVVAWHAQRSGAGLLFRDGPTLAEAVRRLVDTPQEAAALGARGRQYVLDNYRWEVVLDRMEADLEAMMDAGAAGAGGATGGGAFGAGVGGGAGRSGDAGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS8</accession>
    <name>A0A7K0JRS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000350">
        <property type="protein sequence ID" value="MST32642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="10356" checksum="88BD275EA44D5909" modified="2021-04-07" version="1">MAAGRCLNRRNTSPIAELAAARVPVPCSHPDHVVRTCFGRIGGEALAHAACARCDHDWWELDRQPTPFGVVSDLLSAHYEALTRRRPSGDSRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT6</accession>
    <name>A0A7K0JRT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="411"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="496" mass="51652" checksum="BC801E4A997CE2A1" modified="2021-04-07" version="1">MPLIDDLLRHAQDRPHAPAAADPTRSLDWAGLRDEVAAVATGLAARGVGPGDRVGIHLPNSLDFLVVALGAGWLGATFVGLDVSSPPARTVALIADFEPAVVATTATDPPAAGLGAVPTTRPDDLRASGVAVRRPQPPTGPAYLIYTSGTTGTPKGVAIGHAALDASLSAMNEIIELTPSTRSMCVSPFHFDGSYATLLGTVHAGGFVTIPDRASLVFPRNFLRWIEHHAVDVTGFTPTYLRLLAAGRALPAIGSGSLRVLGLGGEALAATDVLALLRAAPELRVFNRYGPTETTIAVAHHRLGAEDLRPGEPVPIGRPHRGTRFLVLTDSGEPVPAGRAGELWIGGPQLMDGYWGAPELTASVLQDDVVPGEALYRTGDIVRAGSDGVFTWLDRADRVVKRRGLRISLAEVANALMTVDGVEGAAAVAVGQAPDTRIVAFAVLRGCSVEAARAGAGERLPEAMLPDHIVHVESLPLTSSGKLDERRLLADAASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV1</accession>
    <name>A0A7K0JRV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4395 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000350">
        <property type="protein sequence ID" value="MST32643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="2">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="14318" checksum="876A0759FDD5991B" modified="2021-04-07" version="1">DRLWLTVPLAYGFAARVLTGPTLSPLGQLATRLVVPRLGGDPRPVSGAPKRLAQGMGLALSSTALVLGVVLGRRRAARLVLTVLLGAAGLEAFAGVCLACKLFPLLVRAGLVPDDACPDCANIWDRLHHAEREPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS10</accession>
    <name>A0A7K0JS10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000373">
        <property type="protein sequence ID" value="MST32738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="297" mass="32288" checksum="EF8D6D98D0EF37B3" modified="2021-04-07" version="1">MRVEHLTRRYGTATVVDDVSFAVGRSEVLGLLGPNGAGKTTTIEILEGLRVPTAGAVRVLGRDPRRGGRRLRNEVGVVTQAVGTDATLTVAELVRLHASFYRPRRAAEEVIREVGLRDSAAMRVGRLSGGQRRRLDLALALVGFPSVLFLDEPTTGLDPGARRRTWAVIERLRRSGLAIVLTSHYLDEVQRLADRVVVLSRGRVVGEGPPGHLSGPTAPTATISFRLGGPVDLPPGPWESVSRAGGILVVETREPVEAARILLAWAAEARVDLDELEIRQPSLEEEYLRLTSHPRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS81</accession>
    <name>A0A7K0JS81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_08680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000391">
        <property type="protein sequence ID" value="MST32795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="481" mass="50794" checksum="3A49676D3ED6FAD8" modified="2021-04-07" version="1">MSTRNDAKARALGIPSATGLVIGSIVGTGVFTMPAVLAGAGTMSLLVLGVIAVGAMVLAVLFGQLTKRIPNADGGLYAYSRHEFGDFAGYLTGWCYWVQSWAGNAAIVASWVFYVDALFGWKPSGLGNWGIALVGLWIPAVINLLGVRQVAWFQNISVVLKFLPLLFIGLVGWFFVSSGRFGAFNMSGGSLYAGIGIAAGVALFSFIGVEAAAMTAKRVRDPERNVGVASLLGTGLSAVLYLLTSAAVMGLVPHTALVATGSPFVNAFDAMFPGTPWAGKFIAAVAVVSGIGALNGWTLLITETSRAIAQDDLFPRPFAWEDRNHTAWFGILVGTLLPSLLMLWRYEASTGLTVFTYLVDLTVVTVAIPYFMSALAQLTYLVSTRRRVQGWALARDLMVSAVSVLFAMWVTFAAGYQAVYQALVVLLAGLILYAFLNARRQRLGEAPTPVDAAVPAAGAAVSGRNGAHDGRAALAPRRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS89</accession>
    <name>A0A7K0JS89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenocysteine-specific translation elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000393">
        <property type="protein sequence ID" value="MST32800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="80" mass="8553" checksum="811A39F2BD37049C" modified="2021-04-07" version="1" fragment="single">MHVIATAGHVDHGKSALVRALTGMEPDRWEEEARRGMTIDLGYAWTLLPSGEEVAFVDVPGHERFATNMLAGVGPAPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA4</accession>
    <name>A0A7K0JSA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000402">
        <property type="protein sequence ID" value="MST32828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="650" mass="69071" checksum="96C4930A4C40466F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB6</accession>
    <name>A0A7K0JSB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_06960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000300">
        <property type="protein sequence ID" value="MST32459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="28271" checksum="EB9AF996B96A1D7C" modified="2021-04-07" version="1" fragment="single">MAEVWEGRDEVLGRAVAVKVLQSHLSGDAVFVERFRREAVTAAAVSSPSIVATYDAGLDDGTAYIVMELVDGRTLRQLLDGSGALDVGLAVEIAAQIADALGRAHRAGLVHRDVKPANVLVCDDEDGGVRAKVTDFGIAKARAGLGADLTQTGTVLGTPKYLSPEQIQGRHEVDERADLYSLGIVLFEMLTGQVPFTGPADMTIALAHLHDPAPRVRSLRPAVPAALDDLVARLLAKTPEERPASASEVRRALLAAPPAGVHAALADTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD0</accession>
    <name>A0A7K0JSD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000405">
        <property type="protein sequence ID" value="MST32840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17945" checksum="FE5983D99605D01A" modified="2021-04-07" version="1">MSTPLLTILKYVFLAVLYLFFLRVLRAVWIELREPKVTTVEAGGTPLGAPRPSVAPVPVDGSDPPTIVTGLGPETLVEAGPDGLPGRRFPVGNEMSIGRSPGCGVALPEDTFVSQVHARVFRRDGMVWVEDLGSTNGTYVNDSRVDGAAPLRPGDRLHVGQTVLELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK0</accession>
    <name>A0A7K0JSK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="9227" checksum="418F09CF2F478E07" modified="2021-04-07" version="1">MLRTQISLTEEERRLLDDEARRTGRSISALIREAVSTVYGPGRSSEADLAAMRAAFGAWKDRTDYGAAWVDQLRSGSRSSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL8</accession>
    <name>A0A7K0JSL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000436">
        <property type="protein sequence ID" value="MST32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="75"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="35735" checksum="A911B4775B7579AD" modified="2021-04-07" version="1">MSAPALRGYQVGSFAVGNRLVEADRRTVQSGEGRVNSLTSGHRACQGCGEALGARYVLDAAMRAAGGRLLTVNATGCLEVFSTPFPESAWQIPWVHSLFANAPAVAAGIAAALQAQGRSDVRVLAQGGDGATVDIGLACLSGMFERNDDVLYVCYDNQAYMNTGVQRSGATPPAARTATTEAVGARPGNPWGQGKDLPRIAMAHAIPYVATATVADLHDLERKVTAAMAVRGARYLHVLVPCPLGWGSNPGDTIRLARLAQQSGLFPVLEARGGEVIDVAPIRRRVPVDAYLQPQARYRHLFHPARDEETIGAVQALADANVTRWGLCRGGTASEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR9</accession>
    <name>A0A7K0JSR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-6A synthase (Deacetylating)</fullName>
            <ecNumber evidence="6">2.1.1.152</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.152" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043819">
        <property type="term" value="F:precorrin-6A synthase (deacetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11643">
        <property type="entry name" value="Precorrin-6A-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012797">
        <property type="entry name" value="CobF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036525">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02434">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="27400" checksum="D7102B81D9E82EC6" modified="2021-04-07" version="1">MRTVEVIGVGMGNPRHLTQQAVDALRRVDAFFVLEKGSAADELAELRRDLCRAVIGTGDYRLVAVPDPPRDRSATAYAQAVEDWTAARGEVLLDTMEAHLEPGQTAGILAWGDPAFYDSTLRVLDGGRATGRLEVEVVPGISSIQMLAAAHRISLTRVGQPLQVTTGRRLAEEGFPPGCHDVVVMLDGACSFQHVDPGGVDIYWGADLGGPDQAVIAGGLGEVGDAILARRAEIRSRRGWVMDTYLLRRDVRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW3</accession>
    <name>A0A7K0JSW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="8">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagA</name>
        <name evidence="8" type="ORF">GHK86_09815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000456">
        <property type="protein sequence ID" value="MST33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="287"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="36634" checksum="14695B5E781E8DE1" modified="2021-04-07" version="1">ERIVASGGPPAPTGPATADLGDLVVAPGFVDVHVHGGDGHQVNGTDPEAVHAAVLAVARAHAAHGTTALVAATVSDTIDALEASLAGVARAAASPPGGGAQVLGSHLEGPWLSPSRRGAHDPSLLAPPDGDTVRRLLAAAGGTLRLVTLAPELPGGLEAVRALTAAGVTVSVGHTDTDAEGARRAFAAGASHLTHCFNAMRPLLHRQPGPVGAALADDTVTIEVIADGVHVDPVVVGLLARLAGPRLVAVTDAAAACGLPEGRYHLGSLPVDVAGGAVRLAADNGTLAGSVLTMDGAVAGLVAAGVALGDALHAASTAPAAAVGAGRKGTLDAGADADLVLLGPDLRARATVARGRVAHDADGLLEGVLEAAPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT27</accession>
    <name>A0A7K0JT27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000485">
        <property type="protein sequence ID" value="MST33101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="10959" checksum="1A46ED99008B78E4" modified="2021-04-07" version="1" fragment="single">MPSSIPTQAQAASNGINANTFLKLLVAQLQYQNPNSPSNPTQYLTQTAAFEEVQQLDSLQTSVQALTQQQQVSSGVAMLGQQVTASTGTSGSSVSGVVSAVQLTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT56</accession>
    <name>A0A7K0JT56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000497">
        <property type="protein sequence ID" value="MST33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="484" mass="51138" checksum="3447795E74604E0A" modified="2021-04-07" version="1">MAVVVASRRDFTLDNYRRVSVHGEGVTLGEEARRAMAASRTGFERLLRSQPGTFVYGTTSRPGIEVGRTLTPDEQRSSTWSLHGERSPSFGTDALEERVVRGMVFARLANYVEGHANSRPEVADAIAGLLDDPLPRIPLQGEVGPGEVIPLSHLMAGLSIDLLPGERMALVNGSPCAAALGADIAIGAPGRQAAAEATFALSVEAFRAPLEAYDPALGDLWGDEGETAALSGLGSWLHDADADNRLGHQAPVSYRILPKVLGQSRRAIAELRRAAAVSLRSVSDNPVYFPPDDVHPHGRAISTGGFHNALVPPALDAVSAAWADLVLLAERHVTALHVGQTADHLPHLLARPGGAGGRTNLLGWVAGSYLEEARSAATMTHLPSGWADAQNDVANPTFAAYRKHREVARCVDAALALLAASSSQALWVTDRLPAPALRPLLDRVRSIVPPLDDPAGRAMGEELARLGAALAGLVRPPASADVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT75</accession>
    <name>A0A7K0JT75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_10455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000498">
        <property type="protein sequence ID" value="MST33138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029499960" evidence="7">
        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="157"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="500" mass="54945" checksum="79029D0F5A278CB1" modified="2021-04-07" version="1">MLTTVASSTTISCATVSAARIHQRRLVGAPAPTGAPVGGWSASSSVMGTPVTAACGGRSSTSLRSQRTSGGPSSGCAGDVGHRSGGCRAGSAAAARHLIEGSVRDGYADGVASTELPAVDPDEIDRILAEGATLPGSFYTDPRIATLEDEAVFRRTWQIVGVEPEVRRPGDFFTSHISGTNFSVPIVVTRADDGRLRAFVNVCRHRAHFVAVGCGHKKFLQCSYHGWTYKLDGSLNSVPRSDEGGLPPFDRLGLYDLPVDTWRGYVFVALQPAEPLSAAVTGLGTVLDDVGFDFPFAAENADPDFEYVRQVQPMSGPSNWKAMNENNIECYHCPTTHRHSFSDMYKVDPAHYLHREFDRGVYHTSDFQDRVAATLGLTERGGAPEYQFYYLWPNMYLQGGIELGFGGTVERLWPDGVDRWKGEIVSYALPSSREYDPDVIKQVEEWWRLTVEEDRDAAGRVQTGLKSGLYSWGYTLPESERNMRHFYRLVWEALAPSFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA1</accession>
    <name>A0A7K0JTA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="17981" checksum="4AC21A67FEEF4909" modified="2021-04-07" version="1">MTAAAVVVVDAGADLAETLSRVEDWLRWCTPRTAQGADRLDAGAAAAAAVAGALRRSSRRVSTLDGAELAAVCVLPGDLAATLAALQAAAVEADEPGPPGGPEALAFLARCCEHAGDPETRLLAAVALATPGDRPALLDGTGLLAYRRLVAATIRDPLDAFVALPPPRGPFPSAGIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ0</accession>
    <name>A0A7K0JTJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000531">
        <property type="protein sequence ID" value="MST33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="309" mass="31948" checksum="ED681B0E8C07DD01" modified="2021-04-07" version="1">YHLGWTDRDGRPAGAPGGKGIRPTLALLSAEAAWAEASVGIPGGVAVELVHNFSLIHDDIIDGDHERHHRPTVWSVYGIGPAIIAGDALETLAHQVLLEASATTGPGASAALAEATAAMIAGQADDIAFEKRRDVSVDECMAMSAAKTGALLGCASSIGAVLAGAPPATVGALRDYGRHLGLAFQAIDDLLGIWGDPARTGKPAGNDLRQRKKSMPVVSALAAGGEEAEELRDLLLGPAGAEDPLPPLEGGEVERAAYLVDACGGREWTTVRAKAHLDAALGALERVRISAVPHRQLADLAVYVVERES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN3</accession>
    <name>A0A7K0JTN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YccF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000555">
        <property type="protein sequence ID" value="MST33306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="14065" checksum="2D2D9E2275E8EFDC" modified="2021-04-07" version="1">MRTIGNILWLLLVGWHTAVAWLVVGLLLCLPIITIPFAVQCFKFAAFTFWPFGRVAVRSTDTPGASLVGNILWLLPGLLLALGYFLGGLLLCITIIGIPFGLQAFKFAGLSLHPFGRIIVTRDEADAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ0</accession>
    <name>A0A7K0JTQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000559">
        <property type="protein sequence ID" value="MST33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="406" mass="43994" checksum="688DF7A5EBCC9C86" modified="2021-04-07" version="1">MSEPTSEGNGSVSSAAPAFVVTPARSGSTMLRWLLDSHPDIACPSETDVAKLAATYLEASARVGHPDGEDAAMRNARSVVDGLMDTYVRAKGKSRWCEKSLTTIEHIDVVAQAWPEARFIFLYRHGMDFVGSALEAQPWGLSEYGFGEFAKQHPTDNVAALVAYWHDRTGRMLEAETRLRGRSVRLRYEDLVGAPDAALGPVWELLGVAPATELSNAAFTQQHDAIGPADHKIWQTSAVHQDSVGRGARIPPGRVVEHLRVAMNRLLAPLGYPAVDQWWGCGGPPPAETSDHPSHLDLRIVDGHRSLWRSVLDLAEGKSYDPSTVAPPRIVAAVERRRLPELVADGSSLPSAIRGGYVRWYGPRFTSYAAERAFFSGLAAFLSAHGQHLYDETGREAAPAAGGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU4</accession>
    <name>A0A7K0JTU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000572">
        <property type="protein sequence ID" value="MST33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="180"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="40134" checksum="36AE96C811830C2F" modified="2021-04-07" version="1">MRHLLVTNDFPPKTGGIQSYLWELWRRLPPDDVVVYTTPHSRAARFDGEQPFRIIRSREPVLLPNPLLAHRVRSLAREVGAEAVVLDPALPLGLIGPGLGLPYATVLHGAEVTVPGRLPATRSMLSRVLTHASLVIAAGSYPEAEARRAAGRAPLPPVANIPPGVDVERFVPLPGIERAAMRARLGLDPGARLVVSVSRLVPRKGMDTLIEAAARLTPHHPDLQVAIGGTGRDERRLARLAERTGAPVRLLGWVADADLPGLYACADVFVLCCRNRWGGLEQEGFGIIFLEAAAAGVPSVAGNSGGAAEAVLDGETGAVVAHPDSPAELAAAIEELLDNPERARKEGQAARTRVEEEFSYAALAARLGEALESMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY5</accession>
    <name>A0A7K0JTY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF512 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000448">
        <property type="protein sequence ID" value="MST32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="452" mass="48208" checksum="433FD31855FE367C" modified="2021-04-07" version="1">MSLPRVVAVAPGSPAALAGLQPGDEIVALDGQLPRDIIQYQLLADQETLEVELRRGGLELTATVERDGGTPLGVEVDAALFDRVRTCDNHCEFCFIHQLPKGLRKSLYTRDDDYRLSFLYGNFTTLTRFTEADLERVVTEGLSPLWVSIHATDPDVRARMLRNRRGATSLRWLRALLDQGIEVHGQVVVCPGVNDGEVLDDTLAGILDHFPELASAACVPLGVSRFNTEGDMRPHTPGEAASVVALVEGWQATFERAVGRPLVYASDEYYLVAGLEPPPLDRYGQVAQHDNGVGMLRSFEARFAGRADLPGGGPGGFFQSVDGAPAAGYRAPRAPGAVTLRPRATAPVTVLTGRYAAPWIARLASGVRPDVDVVAVDNRFFGGNIAVAGLLTGADVGRTLADLPLGRRYLLPDVCLSGGRFLDGMGLEDLPQAVEVVPADGASLRAALAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU16</accession>
    <name>A0A7K0JU16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000592">
        <property type="protein sequence ID" value="MST33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6798" checksum="FFA332AA91DA3F2A" modified="2021-04-07" version="1">MLGPQPLRLLPAGDLGPGELTDRHAHRVGQHHSGLPASLDGILPGLLRRRAPNPSQRGRVVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU45</accession>
    <name>A0A7K0JU45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000603">
        <property type="protein sequence ID" value="MST33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="32803" checksum="F7FA26FBEE58F187" modified="2021-04-07" version="1">MSPAATSVDVGGRTLQLSNLDKVLWPATGFTKGRMIDYYARIAPVMLPHLAGRPITLRRWPNGVEAGSFFEKNCPSHRPDWMPTIDQGGVGYCLLEEPAALVWTANLAAVELHPTLASAPDLDRPRSVVFDLDPGPPADLVTCARVAQLLRALLDRLGLAAWPKTSGSKGLQLYVPLNTPTGYERTRAFALGLARVVEQAHPDLVVTTQDRSVRPGKVLIDWSQNHPTKTTVSVYSLRAWTTPSTSTPVTWDELDDAARREDAERLRFSPEEVLQRVEDRGDLMAPVLELEQEVPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU84</accession>
    <name>A0A7K0JU84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_10485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000500">
        <property type="protein sequence ID" value="MST33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="15749" checksum="7600D72ED71B412C" modified="2021-04-07" version="1" fragment="single">MTTTPVRSRTVESMGTVFSFTWTPPGADVDAALAAAAARLAAVDEVFSTWKPDSPLSRIRRGELREEDRPDVAAVLDRCRELRELSAGWFDPWAAPGGVDPTGMVKGWATAQACSLLGAAGVTAGLVNGGGDVATLPGAGPDGSPGWRVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU95</accession>
    <name>A0A7K0JU95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000620">
        <property type="protein sequence ID" value="MST33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="11582" checksum="C58E7049E332B5BA" modified="2021-04-07" version="1" fragment="single">MLVGAGLSQTWSHHRAHRFFSHATWSIQQVSAVLAGAGRTAGRHLLLQAGAGLVVGSGVTSWVLDDQDLAQRVRDSASIAHALAGIDRHLHPVYDHHPSLSEPLLWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD6</accession>
    <name>A0A7K0JUD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4031 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000493">
        <property type="protein sequence ID" value="MST33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025109">
        <property type="entry name" value="DUF4031"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13223">
        <property type="entry name" value="DUF4031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4031" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="6246" checksum="72EB8FBE22C74AC8" modified="2021-04-07" version="1" fragment="single">MILVDEPHWPWRGRRWAHLVSDHSYEELHRFAERLGIPRHVFQGDHYDVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH2</accession>
    <name>A0A7K0JUH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000660">
        <property type="protein sequence ID" value="MST33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="28728" checksum="1B0DD9EBBFBD01B2" modified="2021-04-07" version="1">MTAVAPAPARPDRPVRHAGLVDALRAEWAKMVTLRSTWITLGVAVVLGVGGSAGISAAAAHAYRQGHIGPRGWQPAQVSLVSLFFVQWAMAVLGALVITGEYGSGMIRNSLAAVPRRGRFLAAKATVLTVVVFVVGEVIAFGSFLLGQVMFGSGVPQATLSNGATLRAVIGAGLYLTAIALLTTGLGFLVRATAAAMAIIVGLLFIFPIIFGAIPVSWLKQVNKWWPTQAGQQVYSQVGPHASDVLGPWAGFGILCAFVAIVLAAAYWVLRTRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK7</accession>
    <name>A0A7K0JUK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000669">
        <property type="protein sequence ID" value="MST33637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="19206" checksum="DFFCE12FEE0C3318" modified="2021-04-07" version="1">MPEPPAVPPDTRDWTFVITEGCGECGFTPQPPETTGDRLRATIPLWRRALASGSARQRPAPAVWSAVEYGCHVRDTCRLFRDRLALMLAADDPEFANWDQDVTALEDGYVHQDPAVVAEALAAEAQATAAAFDAIVPGQWHRTGRRSNGSVFTVGTFAVYFLHDIEHHVHDVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM8</accession>
    <name>A0A7K0JUM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system HicB family antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000666">
        <property type="protein sequence ID" value="MST33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7611" checksum="3F0FF4567CC7EB48" modified="2021-04-07" version="1">MTEYVVVIEQDGAAWGAYVPDLPGCVAVGKTRAEVERLIAEAIPLHIESLREHGERVPLPAATGSMKVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP3</accession>
    <name>A0A7K0JUP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome small subunit-dependent GTPase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsgA</name>
        <name evidence="6" type="ORF">GHK86_10915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000528">
        <property type="protein sequence ID" value="MST33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="44"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="290" mass="30360" checksum="7D3770C912B4ABAC" modified="2021-04-07" version="1">AATAAAPAVGDWVVIVGQRLGAVLPRWSSLDRQDPATGGVQTLAANVDVVLITVPGDRPNVARTERELLVAWESGARPVVVVTKADLAPGDLVDELSGRLVGVDVLATSAETGKGIAEVGALLATGTTGVLLGPSGAGKSSLTNALLGERRQAVAAVRADDRRGRHTTTSRHLLRLPAGGVVIDTPGLRSLGLTSAHRIDEAFPDIDELAGGCRFADCAHRSEPGCAVTAAVAGGSLPGQRLASYHKLEREAAAERRRSDAAERLATRRVWKQRSKDARRLREQRERGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS6</accession>
    <name>A0A7K0JUS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">rlmN</name>
        <name evidence="15" type="ORF">GHK86_13385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="WJHE01000695">
        <property type="protein sequence ID" value="MST33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="93"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="363" mass="38886" checksum="A97605131E5B6AF9" modified="2021-04-07" version="1">MPSPYELDRDALAGLLADQPPYRAAQVWRGLHQGLRRPAEMTDVPPALRARLETALPPALREVTRSVADSGDTVKWLWALHDGARVETVLMHYRDRSTVCVSSQAGCAMGCTFCATGQGGFTRHLAAGEIVEQVVAAAREARSTDRRLSNVVFMGMGEPLANYDRLWAAVTRLHDELGLSARHLTVSTVGVVPGIRRLAGEALPVNLAVSLHAANDELRDRLVPLNRRYPLGALLAACRHYLAAKGRRLSFEWALIDGVNDRDADVDELAQLARPLGAHVNLIPLNPTPGYPVLGSPPARVRAFRDLLTASGVNATVRRNRGTDIDAACGQLASRVAGDGARPVALGSPAGRRAGRVSAPAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU3</accession>
    <name>A0A7K0JUU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000701">
        <property type="protein sequence ID" value="MST33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF_alpha" evidence="1">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16224" checksum="78F0D7C7C9C81B91" modified="2021-04-07" version="1">AAVRAVATAADDADLRVRVDEVVAPGGDGVSLSDARVIVSGGRGVGGEEGFAVLEELAGLLDAAVGCSRVVTSEGWRPHRDQVGQTGTRVSPDLYIACGISGAIQHMVGCKGAKKILAINTDPEAPIMARADYSIVGDLHAVLPAVVAEIRRTREGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU4</accession>
    <name>A0A7K0JUU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000702">
        <property type="protein sequence ID" value="MST33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="375" mass="36984" checksum="20141195FEF92E0D" modified="2021-04-07" version="1" fragment="single">MAGMDLEGVPGDPVRANRWLPVAGFALVSSANQMLWLNFAPIATGTAARLGVSSSTVGLLAEVFPVIYVLLALPAGLALDRWFRPTLAVGTVLTAAGAVLRLAGHGFGPILVGQLVVALAQPAVLTAVTGIATRSLVPADRPSGIAVGSAGTFLGFVLAFVLGLACGAAHLHLLLVISAAYAVAGAGVLLPSLRQVSAVGGGPAVGANRAALRAVWGDPVVRSVAALVFAGFGVFVALTTWVQTLLQPVDVSARAADGMLIAMVAAGIVTAVAVPPAVAARGRQPLVLAVAGVVAFVALALLAAAPGPVVGYVGLAVIGLVLLPALPVLLELLEARCGTHAGAATALLWLSGNAGGVVVALAVQAVVGSTAVAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW5</accession>
    <name>A0A7K0JUW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000705">
        <property type="protein sequence ID" value="MST33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="24077" checksum="5AD38D84D2D6F1ED" modified="2021-04-07" version="1" fragment="single">MAHDPAHAGSLRSALTSRGWTLLGGGAAALIAGRLFGIAELEGLATAAIVAVLGAWVWTSRQAYQLAVHRSLHPPQPAPGRRNAVELRLRNSGPRRTPLLALQDPFDGAGPRQLLAPLGPGGTRTWRYELPELRRGSFRVGPLVAEVNDPFGLARRRRPVGEPSRLVVHPRVLALRAPVVARASRQEGVTSVSQDSGQEFADLREYVPGDDFRRIHWPSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV35</accession>
    <name>A0A7K0JV35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000710">
        <property type="protein sequence ID" value="MST33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="167" mass="17149" checksum="434D391767ACFA79" modified="2021-04-07" version="1" fragment="single">MPIDPSAVGSHTQPIDVAWGSTDALLYAVAVGAGAGDPTGPELPFTTENSEGVRQQVLPTFPVVLAEGDDLYRSVGTFDPAMLVHGEEAIELHGPLPVEGRARVVSTVTGVYDKGSGALVVHETLATDPGSGRALYTIRSSSFIRGEGGFGGDRGPSGRVEPPEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV78</accession>
    <name>A0A7K0JV78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flagellar motor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_14115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000745">
        <property type="protein sequence ID" value="MST33848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="101"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="261" mass="27439" checksum="4235F541FD63FC6D" modified="2021-04-07" version="1">MDPGSLIGIGLALFAIFASLVMDGGNPAALIAPSALLLTFGGTLGVGMASAAFADAKRLPKLIKHALLSPPIEPDGAVGALVGFAEKARHSGLLTLEEEAKATDDPFLRKGIEMVVDGTDPEEIRDVLEADITSMRSRHKAGAKFFSDMGGFAPTLGIIGTVLGLIHVLQNLSTPGKLGPMIAAAFTATLWGVLQANVFWLPIANKLRRSSELEIQRMELLLEGILSIQAGASPRLVEQRLLAFLEPARREAVSQSRAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE4</accession>
    <name>A0A7K0JVE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_14445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000770">
        <property type="protein sequence ID" value="MST33913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="530" mass="58543" checksum="1D9EFA7B3362308B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR5</accession>
    <name>A0A7K0JVR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1634 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000823">
        <property type="protein sequence ID" value="MST34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="11907" checksum="B2BADC70229E4B49" modified="2021-04-07" version="1">MSDTGRAQPADPRTNTAVKVVLRAGLGLSLSLLAIGLVTQLVSGHHRADQVRMFALLAAPTAGGKILAVGTLVLALTPAVGVLTVVASWVRERDRIFVGVGAAVIAVLAAAVAVGALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ5</accession>
    <name>A0A7K0JVZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000863">
        <property type="protein sequence ID" value="MST34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="14734" checksum="998921C826886DC7" modified="2021-04-07" version="1">MSLDPATMRPAPTGARFDAVYGPAAGGRQVRARLQHPDPPPGAAASEWTLRAGDFDVLGHVNNAVTWGLLDEEVERRLPGHRVASAEVEYREPIPGGRAVTVLVTGGEGMLRLWALTDGGTLACTALARVEPGAPPHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW60</accession>
    <name>A0A7K0JW60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AarF/ABC1/UbiB kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000886">
        <property type="protein sequence ID" value="MST34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="76"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="468" mass="51808" checksum="964AE0458AB4C425" modified="2021-04-07" version="1" fragment="single">VARTGAELGQALALWWLVERAQSRRWQRPEVSRAGVSRRLRRAFEHLGPTYIKLGQIISSGEGLFPAELVAEFRLLRDRVSPERFEDVRAVVEGDLGRPLEEVFSSFERAPVAAASIAQVHAATLRSGERVVVKVQRPDVAATVRRDLAAMSWIAPALIGRIPVAALANPPALVELFAETILEELDFRLEADNMLDIAHVLAVTGQRSVVVPRPHPRLVTRRVLVMECLEGFSFDDVEGMRRAGIDTEAVVRALIISFLEGATLHGVFHGDLHGGNLFVQADGRVALLDYGITGRLDEPRRLAFLRMLMGGSLNDPRMQLAALRDLGALPPDTDLDAVVRDLGLDQPTQDPTTMAPDDLLREVREVTKRLLAYGARFPKVLMLFVKDFLFIDGALATLAPDVDLFAEITQIATYFTLRHGQRIAGDIGIDPRDNPVDLEGVRAAVGVSSDVDRLTYRELQERRALIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC6</accession>
    <name>A0A7K0JWC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000888">
        <property type="protein sequence ID" value="MST34182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="32169" checksum="B6ED1C9AA5655CD2" modified="2021-04-07" version="1">MPLTAVDLWSPHHGLSLAMAIVTAFLLGVVHGVTPDEHTWPITFSYAIGSFSARKGMRSALSFSLSFTLQRALLSEIAYLGLLQVADNATWNAVIYLVVGLVMVVAAFYVLRLRCAFHLHLWPPSIGGCHRPRHADTAEWAGRTPTPAMAAVHGFLAGWGLGAFALIMATVLAPAMPSAALGWVPGAAFGLGTTAVLAGAGAAIGALIRHQRLPAHLAEQVAQEGAGWTLLVGGALFAAAGAAALVAPALLTAGIRTGIHVHNLDRIGVGTLLVALVVVVAVATIGRTVRRLRRCTPGSRGRRRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF2</accession>
    <name>A0A7K0JWF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3501 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000926">
        <property type="protein sequence ID" value="MST34277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021890">
        <property type="entry name" value="DUF3501"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12007">
        <property type="entry name" value="DUF3501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="199" mass="22545" checksum="3C3A0744191C315C" modified="2021-04-07" version="1">MTGRLTIADIADLRAYEREREALRARIIELKRVRRVPVGPIVTFVFENRDTIRFQVQEMARAERMLTDEAIQAELDTYNPLIPETGQLSATLFVELTSKEQLQEWLPRLVGIERSVELLVGEGERATVVRCRVDDAHAARLTREEVTASVHYVHFDVPPAVVDRWLDEPVVLAVNHPAYAHGVTLSLETKGSLLGDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH4</accession>
    <name>A0A7K0JWH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF255 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000906">
        <property type="protein sequence ID" value="MST34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="665" mass="72439" checksum="EEFDC05A7C634264" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK1</accession>
    <name>A0A7K0JWK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000945">
        <property type="protein sequence ID" value="MST34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="12766" checksum="2F13AD7078A78D18" modified="2021-04-07" version="1">HVVAYTTRTDQALLYRLCGDRNPLHSDPVFAARAGFDRPILHGLCTYGFTARALLHTLCGSDPGRFEAMSARFTRPVFPGQQLTVSIWDRADGSAAFRTDSEDGTVVDGGVFRYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY9</accession>
    <name>A0A7K0JWY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001020">
        <property type="protein sequence ID" value="MST34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046262">
        <property type="entry name" value="DUF6295"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19812">
        <property type="entry name" value="DUF6295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="9744" checksum="AC55DBAE02019CBF" modified="2021-04-07" version="1" fragment="single">MCTYMTEKFAITGSGKGPLAGSPAPGASGAGGPAAGWVGLSEAMVYFDHPVHVPVEHSLNIDFLAPSAGPAARVAVELDAASAKALAEAILATLEAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA0</accession>
    <name>A0A7K0JXA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001042">
        <property type="protein sequence ID" value="MST34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="28632" checksum="B96257B93D08A75E" modified="2021-04-07" version="1" fragment="single">MHDPVPPAELRIGTLEVAPGSPVTAFCYLTNPTDQPREFTLAVEGFAPAGDAGAVEVTIAGRVGPVAPQSTVSVPIRVLVPAGYPPCTLVGAVRADAVGGDGTPAGGSTTGALRVVIADGAAVLATLEPAEVQGAYGAKLDLVLRNRGKTPLRVELSPIQPDPGVDIAFADRSPVLEAGREVRIRTRLRAARPVAGGEQRRPFGIEVRGRSTPVVLEGTLVQRPLLASWLIRGVALALVMALWVAVAVVGITDLGRRVHHDAAARAAATQPTIPPANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU6</accession>
    <name>A0A7K0JXU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000954">
        <property type="protein sequence ID" value="MST34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="14516" checksum="4E4713B61AB98F49" modified="2021-04-07" version="1">AARRMAGAGTGGSIVNITSMNGVAPGPNGGAYGATKAGVALLTQQMALEWGPAAIRVNAVAPGVVDAGMNAPILADPAVREARRSKVPLGRLGTAGDIAAAVAWLLSDQASYVTGQNLLVDGGVTMSIIANLPRPQSVDGVGMRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY07</accession>
    <name>A0A7K0JY07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000988">
        <property type="protein sequence ID" value="MST34404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="48"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="214" mass="23182" checksum="BC4647E125A82B80" modified="2021-04-07" version="1">MPRPSHATAAAELARRDPVVAELVARVGPPRLRAPQDTHFAALVRSVLYQQLAGSAAAAIHGRLVAAVDGEVEPERILALPDEALRTAGLSAGKAASIRDLAAKVLDGSVVLDPRGLAREPDAEVIARLSTVRGIGRWTAEMFLLFQLRRLDVWPTGDLGVRRGYGLAWRIPMPSSRELEPLGEAFRPYRSVVAWYCWRACEVYAGAGDSALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY20</accession>
    <name>A0A7K0JY20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001264">
        <property type="protein sequence ID" value="MST34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="19601" checksum="59A7786D1DEC3396" modified="2021-04-07" version="1">QVFASGDARRYGQVLSTTLGQPLQALVPTTDGLGYWLVAHDGDVYAFGDATAAAPPVLAFVHQDLTTGDRALDWAMAQLGKPYRWGGAGPGAFDCSGLTMMSWWAVGVGIPRVAADQFQSDPHVPLSRLLAGDLVFWATKPAEASTIYHVAMYVGGGRIVQAPYPGQVVSTTWIGGTGLVAQAAAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY40</accession>
    <name>A0A7K0JY40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001006">
        <property type="protein sequence ID" value="MST34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="15926" checksum="554099A0DE5CCB89" modified="2021-04-07" version="1">LAERGVEVVPADARPDAVVVGRTVTLDYDELAGAATAVRDGARFIATNTDATYPTGNGPLPGAGALVAFVATAAGRQPEVAGKPHAAVAALVRSRFGAPRVMIGDRADTDGAFAVAVGTPFALVLSGTTRREDLPVQPAPALVAEDLAEAVDRLLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY89</accession>
    <name>A0A7K0JY89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="4">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_19645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001309">
        <property type="protein sequence ID" value="MST34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="2 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="5">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="43653" checksum="A955C816EB367D21" modified="2021-04-07" version="1">MAEKITMSPDGVLTVPDEPIIPFIEGDGTGVDIWPAAKLVLDAAANKHGRRIEWKEVLAGEKAFNETGNWLPNETIEIFKEYLIGIKGPLTTPIGGGFRSLNVALRQLLDLYVCLRPVRWFQGVPSPVKRPDLVDMVIFRENTEDIYAGLEVQEGTPEAKRLIELLHDEFGWEIRADSGIGVKPVSITGSKRLIRAAINYARERNRKSVTLVHKGNIQKFTEGAFRQWGYELVREEFADVAVGWDDCGGKPGDKILVKDVIADITLQQVLTRPDEFDVIATTNLNGDYLSDALAAQVGGIGIAPGANINYVTGHGIFEATHGTAPKYAGQDKVNPGSVLLSGVLMFEHLGWRDAADDIVRALEATIADKIVTYDFARQMEGATEVKTSEFAAAIVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY93</accession>
    <name>A0A7K0JY93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_17425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001038">
        <property type="protein sequence ID" value="MST34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="131" mass="13023" checksum="74664BFBA6567F54" modified="2021-04-07" version="1" fragment="single">MGAHYTGACMGMPRALGAVSARRALWIMAPLALVGAALASHGVEHTVGHDLLDGPGLSVTGLVIVLGVAFGLTSAFNVLRIPTSTIQILVFSVVGAGLAAGVGVHWSTIATLAAIWVAAPVVAAGAGYLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM5</accession>
    <name>A0A7K0JYM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Holliday junction branch migration DNA helicase RuvB</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ruvB</name>
        <name evidence="4" type="ORF">GHK86_20260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001385">
        <property type="protein sequence ID" value="MST35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="56"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="30903" checksum="3DA9E8C7EB1B95AE" modified="2021-04-07" version="1" fragment="single">MREEAVERAVTPVADPVESAEEVTLRPKRLADFVGQPELKEHLGIVLEAARRRSQPSDHVLLAGPPGLGKTSMAGIIAHEMDASLRITSGPALVRAGDLAAILTNLAEGDVLFVDEIHRLGRAVEEILYPAMEDFQLDIVLGKGPSARTIRLDLPRFTLVGATTRTGLITGPLRDRFGFTARLDYYSSTDLDAIVTRSAGILGVDIEPAGAAEIARRSRGTPRIANRLLKRVRDFAEVRGDGAVTFPVAREGLRVFGVDELGLDKVDRAILDAVCARFGGGPVGLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ0</accession>
    <name>A0A7K0JYQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF503 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001391">
        <property type="protein sequence ID" value="MST35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10606" checksum="9856F8A87895FA12" modified="2021-04-07" version="1" fragment="single">MHVASLTVELHLPLAHSLKEKRAVVTPILEGCRRRFAVAAAEVAHQDLWQRATLGVATVSSSATRVDETLDAVERFVWSFPEVEVTAAQRDWLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR8</accession>
    <name>A0A7K0JYR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hutH</name>
        <name evidence="8" type="ORF">GHK86_20535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="WJHE01001435">
        <property type="protein sequence ID" value="MST35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="468" mass="48418" checksum="3347C8B2A5BC014D" modified="2021-04-07" version="1" fragment="single">MTVVIEPSGLAASDVVAVARHHARVQLSPAALAAIGASRAVVEALAESPTPAYGISTGFGALATRHIPVPLRSDLQRSLIRSHAAGTGPEVEAEVVRAMTLLRLRTLASGRTGVRPVVAQGYAALLNAGITPVVPEHGSLGCSGDLAPLAHVAMVLTGEGEGRGPDGVLRPALELLALAGVEPVILAEKEGLALINGTDGMLGMLLLALEDLRSLCRAADLATAMSVEALLGTDRVFAADLHAPLRPHPGQAVAADNVWRLLRDSPMVASHREGDSRVQDAYSMRCAPQVSGAVRDTVAHAATVADRELAASIDNPVVLPDGRVESNGNFHGAPVGYVCDFLAIAAADLASMSERRTDRMLDVSRSHGLPPFLAADPGVDSGHMIAQYTQAGIVSEMKRLAAPASVDSIPSSAMQEDHVSMGWGAARKLRRSIAGLTRVLAVELLTAALPVGAVPPEADGRGVDPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS0</accession>
    <name>A0A7K0JYS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_20165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001374">
        <property type="protein sequence ID" value="MST35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="276" mass="29230" checksum="1DC3691EEEBD75CB" modified="2021-04-07" version="1">MALVTFSENRLALSGLIVLLLLVLFSFVGPLFYHTNQVSSSLISQNLPPSGGHLLGTSPEGRDELGRLMLAGQSTIEVGLGVGVLATAFGLLYGALAGFIGGAVDVVMMRIVDALLSIPYLFFVVLLAALVRPNLLLVIVVLSAVSWLSTARLVRGETLSLRTRDFVTASRGFGSRANHVIGRHVTPNLLGVVVVNGTLKVADAILAFASIAYLGLGPPPPATNWGELLTAGINNLFDGYWWQLWPAGLLIVAIVLAVNVIGDGLSDVVEIRLQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU1</accession>
    <name>A0A7K0JYU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001452">
        <property type="protein sequence ID" value="MST35128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029577609" evidence="1">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10312" checksum="6801A86FB00D1C40" modified="2021-04-07" version="1" fragment="single">RAAAPAMVGRGRGHILLVSSLAGVAASPASSLYAATKFGLRGFGHALRQDLAGSGVGVSVLLPGFVRDAGMFADSGATLPPGVGTRTPGEVAAAAVAAVERDRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV2</accession>
    <name>A0A7K0JYV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001437">
        <property type="protein sequence ID" value="MST35107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10631" checksum="871B39223C70A8CB" modified="2021-04-07" version="1" fragment="single">MSDQDTFAATLVDEWARAGLTDAVVAPGSRSTPLTAALAADGRLRLHLVLDERSAGFLALGIGLATGRPAPVVVTSGTAAVELHPAVVEAHQAGVPLLAVTADRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ29</accession>
    <name>A0A7K0JZ29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001529">
        <property type="protein sequence ID" value="MST35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6775" checksum="BEDA21CE21B58DD5" modified="2021-04-07" version="1" fragment="single">MVVLILAIAWAGVLVAWLRSRSRGSFGDSVGMFHRHLHVLERTAPATLAPANRLRGPAVSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD3</accession>
    <name>A0A7K0JZD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DprA_WH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001315">
        <property type="protein sequence ID" value="MST34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="58" mass="5978" checksum="7D9A4BB697B703B6" modified="2021-04-07" version="1">MADPALRAVLAAVGWVPTSLNGVVTAAGLPVGAVGAALDQLVRIGAIVEERGWWQRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH3</accession>
    <name>A0A7K0JZH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster insertion protein ErpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">erpA</name>
        <name evidence="2" type="ORF">GHK86_19900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001338">
        <property type="protein sequence ID" value="MST34979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="11875" checksum="30CF62D023F84089" modified="2021-04-07" version="1">MSTTSTETAPITLTDLASAKVAELLAQEGNAELALRVAVRPGGCSGFSYEMFFDTDVADDDVRSQFGAVTVVVDPSSASLLQGSVLDFKDGLQGAGFSINNPNATRTCGCGQSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZK8</accession>
    <name>A0A7K0JZK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_21970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001695">
        <property type="protein sequence ID" value="MST35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="14719" checksum="7170641AB0B8F45D" modified="2021-04-07" version="1" fragment="single">PLGHLADRHGTRVVAVPGALVWAAAYLWYATQVGVHPDFLGEWLPGQVLSGIGVGATLPVVASGGLMTVPALRYATASAVNATARQVGGVLGIAILTVLVAHPAAATLPGDLRHGWELAGWSFAAAAVLALLFGRRAGAGEVESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZX8</accession>
    <name>A0A7K0JZX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AarF/ABC1/UbiB kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001445">
        <property type="protein sequence ID" value="MST35119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="9741" checksum="DE5D762DFF9A8751" modified="2021-04-07" version="1" fragment="single">MSSAPQPSSTGGDAEPVPSGGEAADLAYGAFSSDGPWVIDPDHLEWRVGLDRLRAGVAAQVPLLLRRRRVPPVARVARTGAELGQALALWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMD1</accession>
    <name>A0A7K0JMD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000002">
        <property type="protein sequence ID" value="MST31116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="381" mass="41105" checksum="315ABA208DF97F47" modified="2021-04-07" version="1">MNDLLFALGLVVVVLTGLGVLFTMVLPRRPSGLLRIATLINRSVRLAFVGLARLAPSYEAKDAVLAPIGPVALVAQLLSWAGGFVLGFGLMLQPTTGDLGAGLLQALGSVFTVGAIHPGGPANVPVDVAAGATWVVVVALQIAYLPALYAAYSQREGLVAMLESRAGLPAWGPELLARHQLVGIVDTLPELYSAWEEWAAEVAESHTTYPVLLLFRSPEPWYSWLLALLAVLDGAAMHLAISPGTASSNARLCLRMGFTCLDRIGTTLGWSVDPDPSPEGPIELPYADFERAVTMLAEAGFPLERSAEEAWPDFRGWRVNYETVAYRLADRLIVPPAPWSGARRHIGTDLAEPRRPPHRRPARAADAFRPTYRRPRQDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMD7</accession>
    <name>A0A7K0JMD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfurtransferase TusA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8393" checksum="0FF4019131614701" modified="2021-04-07" version="1">MSDQRASTTLDCTGLQCPLPVIKTAQAMKGLGEGDILELLATDPGVEPDMTAWASRTGNHLLSITQEAGVFHVLLRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMG8</accession>
    <name>A0A7K0JMG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000005">
        <property type="protein sequence ID" value="MST31138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10511" checksum="953765718FE828E7" modified="2021-04-07" version="1">MLSMIYDFDALRRRREAIGAVAARHGATDVRVFGPVLRGETPGGIDLLVDMAGDRSLLDLAALWRDLEALLDHEVNLLTLGGLTDRDAGIVDEAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU3</accession>
    <name>A0A7K0JMU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="501" mass="53262" checksum="8479150C07246640" modified="2021-04-07" version="1">MYGVAGWSPAGSARSQGRRARQVEAEHRKALMAERKTEMEALGQERRSRPFLPAGGEGGPMAGRSYRRLRVPSHRATSEVLAGAYPFLAEEGLGSAGMLVGQDAWSGAAFCFDPWELYRQGALTNPNMSLAGQIGRGKSTLAKSLAARCVAFGRRVYVPGDPKGEWTVVARALGGAAIQLGVGTTNRLNPLDEGPRPSGVDDAAWRAQVDARRTGLLAALGESTLGRPLGPTERSALDAALDAAQTRATVPIMPMVVDALLDPQQAMPGSSVEQLRTDGREVGHALARLVRGDLGGLFDGPSTVAFDPSVPMLSLDLSAISGSDTLIGLVMTCASTWMEAALADPEGGQRLVVYDEAWRLLAQPALLARMQAQWKLSRAWGLANLMIVHRLSDLDAVGDTGSQSRGLAQGLLGDTATRILYNEPFDEAQAAGRLLGLTTVEVAQLPELAKGEGLWRVNERAFVVRHLCTPGELDVFDTDARMTLNLRQFPGSGAEFSGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN12</accession>
    <name>A0A7K0JN12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">kdpB</name>
        <name evidence="15" type="ORF">GHK86_00915</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="WJHE01000032">
        <property type="protein sequence ID" value="MST31293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MST31293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="688" mass="72669" checksum="B676BE03A07EFC70" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNA6</accession>
    <name>A0A7K0JNA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rne/Rng family ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000055">
        <property type="protein sequence ID" value="MST31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
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        <property type="entry name" value="RNase_E/G"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="429" mass="47890" checksum="93F1D0EE251E0679" modified="2021-04-07" version="1">GPTATQIAVLEGRALIEHYVSRPTDDATQIDGNIYLGRVQNVLPGMEAAFVDIGTPKNAVLYRGDVRYDRDDLEAPSADGGAKPTRGRLPGPARDARIEQLLKPRQTILCQVTKNPIGAKGARLAQEVSLPGRFVVLIPNSDTYGISKRLPDEERKRLRRILDEVRPAGHGLIVRTAAEGSTAEELQRDVARLLSQWERIEEKARTSRAPALLYREPSMAVRVIREEFNKDYRGVVIDDRELYEEVRDYVASISPELADRVEYAGDSDDPLPVFERHHIHEQIHKALDRKVWLPSGGSLIIERTEALTVIDVNTGRNVGTSNLEETVFRNNLEAAEEVARQLRLRDIGGIIVIDFIDMEIAANRAQVVKTFREALARDKTRTQVFDISELGLVEMTRKRVSEGLVESMSETCPSCGGRGFLLDESLLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JND1</accession>
    <name>A0A7K0JND1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GHMP_kinases_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000075">
        <property type="protein sequence ID" value="MST31480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="1">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10432" checksum="997A503E9C9174A2" modified="2021-04-07" version="1">MGLLVAGLADAGQLIAEAGDDRLHQDARSHLFPEAPALLAGLRAAGALTSFWSGAGPSLLGLCRSADAEAVGKEGAGLLAAAGVPGHVRVLAPDLDGVVVEPVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK6</accession>
    <name>A0A7K0JNK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000073">
        <property type="protein sequence ID" value="MST31467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="404" mass="43025" checksum="640D9D2330852DD2" modified="2021-04-07" version="1">MVNAQGDVAGVPLDGVRVLDLTTVVMGPYATQILGDLGAEVIVVEGTTLETNRVMGPGPHPQLSGTSLNLMRNKRSLRLDFKHPAGRDALLAVAATCDVVVTNVRPSALARAGLRYEDLAAARPDVVYCEAHGWPTDSERADDPAYDDVIQAGTGVADAFRRQTGTPSLVPTIFVDKLCGLTIAYAIVAALFRRERTGRGERIEVPMSATAASFVLVEHGAGAIPEPPVGAAGYSRILSPHRRPQQTADGWIHVLPYSRAHYESVFAAAPPEFGVDPALYGSGRARIDNADLLYGQLHAVLATRTTAAWMDYFREQGVPATEITTLDELVDRLPVAEHPAAGAYRQIPPPVRFGGATDTTAAIRRPAPLVGEHTEEVLAEVGFDAEQIAGLRASGAIPPDPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN3</accession>
    <name>A0A7K0JNN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000100">
        <property type="protein sequence ID" value="MST31582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="350" mass="37786" checksum="480DF82DC8E8C01D" modified="2021-04-07" version="1">MGDTLLDVEDLHVEFRTRAGVVRAVDGLSLSVGAGEVLGVVGESGSGKSVSMYSVMGLVRDPNATIRGVARFEGQDLLTLSDDRMRAIRGRRIAMIFQDPMTALTPVYTVGWQIVEQLRAHTSMTKREARSRAVELLGEVGIPEPARRVDNYPHEFSGGMRQRAMIAMALACEPTLLIADEPTTALDVTTQAQILDLMRRLMAQHGSSVILITHDMGVISEMADRVVVMYAGRAVEEGPRRDLLRQAQHPYTWGLLGAVPRMDGRRRRLVTIPGSSVSPLDMPPGCAFAPRCAFRMPVCDSRPELEGPPGHRSACWIPMEDRPARRAEATEGAAGGTEGFAASAGAGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN8</accession>
    <name>A0A7K0JNN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_00440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000017">
        <property type="protein sequence ID" value="MST31199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="3">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="397"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="714" mass="78404" checksum="A1F3A9AC5C573A21" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP20</accession>
    <name>A0A7K0JP20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000121">
        <property type="protein sequence ID" value="MST31708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="5949" checksum="C4B39193CD320CA9" modified="2021-04-07" version="1">MATANCTADVHAHQLATGRSYCASCGLPLDNSPAAVQRRRRIASAFTEDHRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP72</accession>
    <name>A0A7K0JP72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN-binding negative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PTHR35802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="24662" checksum="B399483E8FC4BFF7" modified="2021-04-07" version="1">MLIRPWDAALDDAEWQGWLATHEHFGTLAVNNADAARAPVVVPTHFTVSARELLIHLARPNPVWSHLEVAGEVNLTVIGDYAFIPTYWRAKAGGPDEDGVPTSYYSAVQFTCRPRIVDDADGKVEILAAQLADFQPEGRHAPLAVRTPPYGPMLTGIRGVRLEILRVDAKFKYDDANPVEHRQQVIANLEQRDRDLDAAAAAQQRRRLATIGDWRDRAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP75</accession>
    <name>A0A7K0JP75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ORF">GHK86_03255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000128">
        <property type="protein sequence ID" value="MST31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="23197" checksum="5D0D83102851F654" modified="2021-04-07" version="1">MTLFRLDASIRVDGSHSSRIADLVEQEWRSAHPDSGVVRRPVGTEPLPADAWANAVTAARVPAEQRTPAQAEAVALAASLVDELVGAEALLFATPLYNYGVSQHFKAWVDLVITDPRMASGAEPAVAGKPAVLVAVRGGAYGAGTPREGWDHATGWMRRILADVWRLDLLVVESEFTLVGVNPALDQFSELAARMRQEAESLARAHGRTLASRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK1</accession>
    <name>A0A7K0JPK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000151">
        <property type="protein sequence ID" value="MST31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="2"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="434" mass="46394" checksum="AC7956C87B403642" modified="2021-04-07" version="1">LDAAPGWAALGPAGRGALLRRLADLIDERVAGLATVECADMAMLEESLRLRVLSRGARNFRAYAELAETHEERVWTSNGTRNRVIRMPAGPTVVITPWNAPFMLSTWKCAPALAAGNPVILKPAEWSPLSCSLLADLADEAGLPPGVFNVVQGFGEEVGAALVADPRVRRISFTGSPETGRLIARAAAANLVPFTGELGGKGPFLVFADADLDAAAKKAAVMYDDAGQVCLAGTRLLVEASVRDEFVARLHEHIDRHVLGDSRNPATTVSPLIHPDHLARVAGFVERARANGDRVVRGGRVWRDGGLWYEPTLVEPRGNDSEIVQREVFGPVLTLQSFADEDEAVALANSTEYGLSALIWTTSEARAERVGRAVRAGTVWVNTFLVRDLTAPFGGMGISGVGREGGDYALDFCSDLKTLQILDGSTDREGADHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL4</accession>
    <name>A0A7K0JPL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000174">
        <property type="protein sequence ID" value="MST31912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9431" checksum="7AA02C114A6D550F" modified="2021-04-07" version="1" fragment="single">MPETVAVGSHAAEATTPATGDGVAIEVRDVRKHYGEVRAVDGVDLTVRTGEIFALLGPNGAGKTTAVEMLEGYRRRDGGEIRVLGLDPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX0</accession>
    <name>A0A7K0JPX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000178">
        <property type="protein sequence ID" value="MST31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="431" mass="46667" checksum="A7C6424F3B1403C6" modified="2021-04-07" version="1">MASPGSRPPDPRSRPVRPPGHLSAGDRARRRQVIRRRRAVTGAVFLALIVAVVVTVTSTGSGASAKRSAASTAASRRQAHKGTAHTVRKAWTPASWVASLEAAAKGKPGYLQPGSNPSVLPGPVLIADRNNNRLLLVSPKGQLLWQFPTPGHPLPGPFRMPDDSFFSPHGKHILATQESQATISEISLKTDQIVWHYGHPGVAGSTPGYLHNPDDAMVLPNGNVLSADIKNCRLLYISTKTTSLLHIYGMTDPYCYHQPPLRFGSPNGMFPLTNGNWLVTEINGDWVDEMTPAGKILWSTHPPGIQYPSDTNEVRPGVFLVAAYTNPGVIEEFNSQGQLLWRYAPTGKNALDEPSLAMPLPNGDILANDDYNDRVIVIDPHTNKIVWQYGVTKVPGTKPGYLHKPDGVDLAPPYSLTMTHASTMGIPPFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ04</accession>
    <name>A0A7K0JQ04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000200">
        <property type="protein sequence ID" value="MST32032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="329" mass="35741" checksum="17296BEB4C216D5C" modified="2021-04-07" version="1">MSDVVDEPEDAAYGGRRFACDRGEHSSCTHLALPGAFRRLYGDRYELRSSMRGDDALCGCTCHVDCPITVDGDATDWPQRCTCNGAQSRVRAAEHLRTEGEPDLAGLLVKLPGEVYRRRQARRAVEKRAAGNSIEEVVEIIAEEWDRRGLPTMPDAARRRLADALLRPAGRVERLRLRAAVGRDLAGLPLRLKRSADKSFADLTTDLSPSNSYEIASGKGDPIEVVVDAGDAELGRIAAEGLALPSFPRNTTVELRQPSRETVEVWGRPRGKAPIRLGTLPKDSTALFAQHLAAAARVGQSCVVTASFARQADGSWHLFVPPPLTASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ73</accession>
    <name>A0A7K0JQ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6636" checksum="3CDAA24DFCEE2EA2" modified="2021-04-07" version="1">MNAPKDQPVLVEADYVRTAGGFVRFINRSGELGVDEELVRMFKAGRVLEVELVEPDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ78</accession>
    <name>A0A7K0JQ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="70"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="393" mass="42005" checksum="1C41E524FE95713B" modified="2021-04-07" version="1">MWRGPPALGASRAARPARRQPDGNTVAAWAASCMQARRGGHVPGVARKGTSMHDPQVLSIVVDARGAPPVVRLRGELDLAGADVAEDSLVQAADPMVVVDLKRLTFIDGQGIAALLSAKRRIEATGGRLVLRNVPSTVERTIEMAGDQPALLPDGFLRGAGPEAPPPPGNRSADGAAERSRGSRRLPRGVIRGIESSAWFRAADKPYLVVDAELRISAVNAAYEEVTGQPRDSLIGAWMFEAFPDNPADPHGGAANLSTSFEHVLRRGLRHWMGVQRYDVPGSAEGEFVYKEWVPVNSPLVRGGRVVGAIHHVEDVTDVVDGAGRDRVEMTLSARALAVRFPTLGYNQVLGVLTESHRDVAQTLGKLDGGQAVALAVQRLEELSGESPRKNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ80</accession>
    <name>A0A7K0JQ80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000202">
        <property type="protein sequence ID" value="MST32057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="36444" checksum="B921CE6CD91127CD" modified="2021-04-07" version="1">MRSDAGTVPGQRSEDDHGPHGPMACRLGFGCASLFRLRGRRERLRLLACAYDNGIEHFDTAPMYGLGASERELGAFASGPRGNVTLLTKFGRSVAPLGRAARPLQAPLGRRVTAALDTIAREGVVRRVNAALYRPPDYGVAAARGSLEASCRRLGRDRIDILAVHDPPPGVLPPDDLPGWLDEACASGRVGAWGLAGHHSTAVAWGHHLDRPLPVLQYQSDYRSAPVAGMADSYITYGFLRGQLARIRSLLDTRPDLCEHWSGRLQMSLAGDGLADALLEHELAKNVGGVVLIASSREQRIVRAATVAHRHAQQRPAERIRRAAILTDFATACRLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF8</accession>
    <name>A0A7K0JQF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000225">
        <property type="protein sequence ID" value="MST32153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16575" checksum="40489A0757608335" modified="2021-04-07" version="1">MELTAVAIERPEDGNVILGQAHFIKTVEDLHEALALVGPHLRFGLAFCEASGPCLIRTSGNDAELTALAARNAGAVGAGHSFVIVLRGGFPISVLNALKQVPEVCTVFCAGANPLEVIVAETGLGRAVLGVVDGRPPAGLETGEAAEERAALLRRLGYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN8</accession>
    <name>A0A7K0JQN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029484779" evidence="2">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="17491" checksum="33099A3E1F70FA5E" modified="2021-04-07" version="1">MKRHVFVAGAGAVALAASLTACGSSNHSSAPPTTTTTVAPSGTTTTVSGATGSGGTLANDADTLCTQVQRVRSDLAKVSLKNPTSIAALTTDFSRLQSAAGAVTTANASSGHTHQFSTVVSDVDAAVAKGKAAFAAVSKADTAALQSDFTALRTDLSRAGSAAAHTSFKGCQTTGTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP8</accession>
    <name>A0A7K0JQP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000261">
        <property type="protein sequence ID" value="MST32275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="14186" checksum="DC7D65F0AFCCA172" modified="2021-04-07" version="1">MSTGRGPSVVPLDACTTRTVDTARVAATRQRLITPDDAADLAAVFRLLGDPKRIRILFALLEAGELCVCDLAAATDVTETAVSQAMRLLRTAGIVRQRRDGRTVYYRLDDAHVRLLLDLSHQHLAHHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR1</accession>
    <name>A0A7K0JQR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="52" mass="5532" checksum="0E61A9B8D492DC36" modified="2021-04-07" version="1">MCITGSGVVARYHWPSSPAGGAYTDLRLRSYTGHRKSASFQPPAPAQLAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRC4</accession>
    <name>A0A7K0JRC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate 2-dehydrogenase subunit 3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000303">
        <property type="protein sequence ID" value="MST32467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="28233" checksum="0175CCD1CA5F8A2F" modified="2021-04-07" version="1">MPRDLSRPDHLPNLRPGREPPHPSWLPRQRRGTTPQMIGRYPDYDVLAAADSWDPATSRVIEQRMALGRRAYTFFRPDEVETLEAFCDTVTAQDDDPRVPVGRMIDEKLAAGRLDGYQYADMPDDRETIRLLLRGLDETARARYSRPDFAACDPPAREAIIKQLVEGSLQGGTWDRLNVKRAWSVAMRMVLAAFYAHPWAWNEIGFGGPAYPRGFMRLGPTSTREPFERPGATDEDPVPVADELEGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH6</accession>
    <name>A0A7K0JRH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplD</name>
        <name evidence="7" type="ORF">GHK86_07250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000315">
        <property type="protein sequence ID" value="MST32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="25034" checksum="24C74781C29B48D6" modified="2021-04-07" version="1">MSLSVDVRDVTGGVTRQVSLDEHTFGIEPNVAVLHQVVVAQRAAARAGTQSTKTRAEVAGGGKKPFKQKGTGRARQGSERAPHFTGGGIALGPKPRSYKQRTPRKMINLALRSALSDRASEGRVAVVDAWPWTMPSTKDAKAAIAALGIEGRVLVVLAREDEEAYKSFRNLPEVQVILAGELNAYDVLCNDWILFSAATLPGTAAGDAEPVALSPKPEPAAATAEASEPSEPAEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL3</accession>
    <name>A0A7K0JRL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_07530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000333">
        <property type="protein sequence ID" value="MST32572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="391" mass="41802" checksum="C36101E10A70BB92" modified="2021-04-07" version="1">MPPPPTDPELADELVATVRRFVEREVLPSVAALEAADRYPEDLVAGLHDLGLFGATIPVEYGGLGLDTVTYARIVEELSAGWMSLSGVVNTHLIVAALLRLHGTAAQRERWLPLLAAGDVRAALSLSEPDAGSDTRALRCAARRDGDEYVLDGTKLWVTNGERSGLVALAARAPEGVTCFLVEKEPGQRSGGITVTRRIDKLGYRGVETVEMAYTGHRVPADAVLGGPGASGGLGRGLPFILGALELGRVNVAARGVGVARAAFETAIRYAQERRTFGVPIARHQAIAFKLADMATRVEAARLLVRSAAERLDRGERADVEAGMAKLFASEAAMDNAEEAMRVLGGYGYTTDAPVERLYRDAPLLVIGEGTNEIQRIVIARRLLERYAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM1</accession>
    <name>A0A7K0JRM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_07650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000338">
        <property type="protein sequence ID" value="MST32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="299" mass="29962" checksum="14A371F6F2070B01" modified="2021-04-07" version="1">MVRFGGTPRLTHVRWSERPALVGTPIGRLAGRCGTVSVGAGQGGAVDRSAVTWRALFAEVLGTACLVFFGVGTATLSFGFRVTGTSTSAGVVATALAFGLVLMALVYALGPISGCHVNPAVTVAFLVARRIGPTEALGYWTAQVVGAVAGAGALYGVVHTSADYTSAVGLGANGYGSASLIHADALGAFIAEIVLTFLFVLVILAVTRRASNATVAGLAIGLALTLAHLIGIPIDGTSVNPARSLGPALFVGGSALSQLWVFLTAPLVGGTLAAGAYALLYPAGEEEAVTAPAPEEQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP5</accession>
    <name>A0A7K0JRP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_07725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000342">
        <property type="protein sequence ID" value="MST32610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="368"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="402"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="618" mass="67086" checksum="4FC95E4218A9286A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV6</accession>
    <name>A0A7K0JRV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NDMA-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.36" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000356">
        <property type="protein sequence ID" value="MST32672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="12"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="39590" checksum="21474ACB6242822C" modified="2021-04-07" version="1">MRTRAAIMWEYGKDWSVEEIDLDPPKESEVLVRLVGSGLCHSDEHVLTGDLPFPLPMIGGHEGAGVVEEVGSHVTWLEPGDHVIFGFIPSCGRCPSCASGHENLCDLGAHMAVATQVADNTARHHAQGQDLKLMCLLGTFAERTVVNEASCIKIEKDVPLEKVCLLGCGVVTGWGSAVYAADVQPGEDVAVIGIGGIGINAVQGAHMAGARYVFAVDPVPFKREQALQMGATHAFASVEEAQAEIGDLTWGRNANKVVLTLGVGQGSMIGKALAITAKRGRVVVTNLHPASEVQVDMSALDLVLMEKQVVGSLFGSANPRADIPRLLQLYRAGQLKLDELVTSTYSLSQINQGYDDMRNGRNLRGVITSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW7</accession>
    <name>A0A7K0JRW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_08025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000355">
        <property type="protein sequence ID" value="MST32667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="7">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="22852" checksum="887BEE20AA578900" modified="2021-04-07" version="1" fragment="single">MTAGLLAAAAADELRRLGAGPAEGVWRGPGRVNLIGEHTDYNAGLALPFALDRCTAVAVRRRADRRWRCWSRQQPPGAGVDDPVLADLDDLDAAHPAGWARYVLGVAWALERTGVVVPGADLVVDSTVPLGSGLSSSAALTAAVAVALDELTGSDLGAARLVTICHQAEAGFVGAPTGTLDQRAVLLAREGHGLLIDFATGGTETVPLDAVQPLVVVDTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX1</accession>
    <name>A0A7K0JRX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="287"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="544" mass="58062" checksum="1B66CD74A9096AF7" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS05</accession>
    <name>A0A7K0JS05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lycopene cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_06390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000276">
        <property type="protein sequence ID" value="MST32349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="9">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="13721" checksum="F58E7D1C9FAF5D8B" modified="2021-04-07" version="1">MGPDQGKDLPGRPAAGGGGAGVAVYTVWALVAAAVAVALELVVVRSGVLRRPAYWITIAITWAFQIPVDGWLTKLSAPIVIYDPRRFSGVRFPWDIPVEDFAYGFALVTVVLALWVRLGGGAYGRQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS76</accession>
    <name>A0A7K0JS76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000390">
        <property type="protein sequence ID" value="MST32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="45" mass="4898" checksum="EB273C94DAECF9D6" modified="2021-04-07" version="1" fragment="single">MTVTARDWLVAVDPQRVFADPASEWRAPHFAEVVAPIRALAAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS82</accession>
    <name>A0A7K0JS82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000394">
        <property type="protein sequence ID" value="MST32801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="29222" checksum="EB5894FDC656F6F0" modified="2021-04-07" version="1">MAFPVSSHHRAAGRLDTSDLDLESGFAEAPLPPPVLRCLQYMHDVEHHTVCYLRDLLVTSAHRDPEITEFLTVWNYEEHWHGEAIGRVLAAHGRPAGPGRVGRLRDGLPLTERLRPIGFALGSAALPELPAVHLVWGAVNEWCTQAGYGQLARRAGHPLLGELLRRIMRQEGRHIAFYSSAGRSRLERSGAARRLTRVALERLWRPVGHGVVPAEETRFVVRYLFGDEGGAEAAARIDRNVARLPGLQGLTLVARAVDRYGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA3</accession>
    <name>A0A7K0JSA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GHK86_06885</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000293">
        <property type="protein sequence ID" value="MST32444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MST32444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="289" mass="30477" checksum="ED32D1198C97DFD1" modified="2021-04-07" version="1">MPELPEVEALARFLTDRAAGRVLERVEVAALAALKTFDPPVESLVGRRVEGCGRRGKYLCVGTTGPGEPVWLVVHLARGGWVRWRDEAPAARAKPGKGPLALRVGLSEGGFDLTEAGTEKRLGVWVVHDPARVEGVARLGVDPLSAAFTVDALATLLAERPGTVKNVLVDQSAIAGIGNAYSDEALHAARLSPFKPAGRLGGEDVARLHDAVVAVLTDAVERSLGLPAKGLKAEKRSGLAVHGRAGLPCPVCGDTVREVSFATKSLQYCPTCQTGGKPLADRRLSRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE8</accession>
    <name>A0A7K0JSE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="6921" checksum="3D4B0744E2585B11" modified="2021-04-07" version="1">MSSEGQIIPDEPGHLVGLALVSDPAQVVHGGPDGQPSRYAAGDLTGLGIIERSDRISAPAWVPSMATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST6</accession>
    <name>A0A7K0JST6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000455">
        <property type="protein sequence ID" value="MST33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="8575" checksum="5B69E60169423994" modified="2021-04-07" version="1">MAYARRTEKGGPTVQPDQSRSPFVTVAEVANQLRVSSMTVYRLVQSGQLPAVRVGRSYRIRAEDVDRYLGARFTEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT60</accession>
    <name>A0A7K0JT60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein FlgN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000386">
        <property type="protein sequence ID" value="MST32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007809">
        <property type="entry name" value="FlgN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05130">
        <property type="entry name" value="FlgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="20060" checksum="C473BE495AD46518" modified="2021-04-07" version="1">LRSRRPASINAVVTEDPTACSPAALSTILWKQRQLLDLLQFKLEEERLLLANGPAKWVAHATREVEMVVDKLRQAELARAATVAGLAGRLGLPADATLQALADTVEAPWQEIFASHRQAFLQATDEISRLAETSRELATSQRDATRQAINWLAGRSDEPPVTYGASGSAERRRAAHLLFNEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT69</accession>
    <name>A0A7K0JT69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000501">
        <property type="protein sequence ID" value="MST33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="64"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="412" mass="43626" checksum="407D79B464E80F35" modified="2021-04-07" version="1">MTGPDDERAGELTSPPPKPVDDVFAKVEDARVEQWHLAESLGLLPFFRELRGEVGPRMIFEGKPVVMLGSNNYLGLTADPRVRQAAVDAVSRYGTGLTGSRLLNGTLPLHRQLEEELADWVGLEAALVFTTGYAANLGLMVSLLGEGDAAFVDSAAHASLVDGGRFSDGTLRAFRHNRPNSLRRGLRAWREQPDAGGLLVAVDGVYSMEGDLAPLADIAAACSEFGARLLVDEAHALGVVGPDGSGSAREAGIRPDLVMGTFSKSLASCGGFIAGPRPVIDFLKVTCRPLLFTASGVPASLAAALEASRLARSESWRQEAVVANARRLRRGLRELGYDAGGDDRSAIVPVVVGDDWKAGTLWRALLEQGVYTNCAVAPAVSKALLRTSVMATHTERDIDDALAGFEAAASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA4</accession>
    <name>A0A7K0JTA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ispF</name>
        <name evidence="10" type="ORF">GHK86_10565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="16817" checksum="9B54B1706BB9491E" modified="2021-04-07" version="1">MSIRTGLGHDVHRLFPGKVLVLGGVRIPADVGFDTHSDGDVLCHALIDALAGAMADGDLGTHFPEDDPDAEDARSLEFVRAFAAHVRESGYEVVNVDSFVVLGPVKLRPHIEAMRANLADALGVEVARVSVKARSNDGLGPEGEGTACGAWANVLIQAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP7</accession>
    <name>A0A7K0JTP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">GHK86_11250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000548">
        <property type="protein sequence ID" value="MST33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="214"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="241"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="528" mass="57195" checksum="C9CFE056243D7BE0" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS9</accession>
    <name>A0A7K0JTS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_11560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000571">
        <property type="protein sequence ID" value="MST33351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="25075" checksum="32E9DD9A78FA2457" modified="2021-04-07" version="1">MLASLAAAAHGQGWPQVASLLVACGLTSLVGLERQLRGKPAGLRTTAIVGTSSALIVLVSKFGFTDVLAPRLVVVDPSRVAAQIVSGVGFIGGGLILTQRGRVRGLTTAASVWEAAAIGMAAGAGLTLLAAVVTALHFLTVLLYTPLTRVLPGSKSRTVRLVVTYEAGKGALRGVLARCSEHDWVVAGMDRSPAGAGLRGLLGDEAHEAQLVRVALSLTGPQVASAAGVVGAVEGVREAHLGEPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT9</accession>
    <name>A0A7K0JTT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000568">
        <property type="protein sequence ID" value="MST33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="65"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="295" mass="30361" checksum="ABDFC6EF412ED801" modified="2021-04-07" version="1">TTATPPAAPGVAAGSSTTTRSSGDHGAPVAGAPLPRIVAYGHDHGEVLLGQLIDFVSPGATRPAIVLIHGGSWMHGSPVEMAPSARVLASAGFVTLNIAYRLATPGHPGFPGELEDVEQAVRYLRDHAAGLRIDPAAIGALGSSAGANLALLLATATRGSCLTGDRVAAVVAWSGPVELSEHGQEARDLCRPSAVGCTPLPQDVRTYIGCSIAACPQRWRDASVPVHVTADDPPALLFNSRDELIRVGQARAAAAAFAAHHVPHQLVLLPGDRHASAYASTALPATVAFFRHWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL4</accession>
    <name>A0A7K0JUL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">GHK86_13045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000670">
        <property type="protein sequence ID" value="MST33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="35894" checksum="6795FBB636507521" modified="2021-04-07" version="1">MAGGQERILRRRIRSIQSTKKITRAMELIAASRIVRAQQAIAAARPYVDKMAEVVGHLADTPDARNHPLFREPESLRRAAIVVIAGDRGLSGAYNSSVLRAAERRIRELEGAGADVMLVSVGRKVGNHFRYRHREPAAAFTGVADRPGPDDAKAITDVVMEAYATGELDQIDLVYTHFESIGRQVVTVRKLVPIERSAPTRSAVTGEVERDASTGRPVDHAQEHFVDYEYEPGPAELLEYLLPSWLQGEVLAALLSASASEYVARQRAMKAATDNADDLITTLTRVMNRARQDAITTEIMEIVGGAEALRGGADETVHTETYEDPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM7</accession>
    <name>A0A7K0JUM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-guanine transglycosylase</fullName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000677">
        <property type="protein sequence ID" value="MST33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TGT" evidence="1">
        <location>
            <begin position="15"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="22792" checksum="2610C96F1AC5D3EB" modified="2021-04-07" version="1" fragment="single">MTAAEVTVEASDGLARAATVAIGGRRFETPCFMPVGTRGAVRLLDGADLDGLAPEVVLANTYHLMLRPGDDVVADLGGLHRFTGWDGPMLTDSGGYQVFSLSPAVDDEGATFRSTYDGSRQRLTPESAVAVQERLGADIQMVLDVCTGLPAPDEQVRRDLDRTLAWAERARPVHRRPGQALFGIVQGGIRPDWRAEAAGRLRALEFDGYGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP2</accession>
    <name>A0A7K0JUP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000546">
        <property type="protein sequence ID" value="MST33284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="33605" checksum="65480661EBEC0CBC" modified="2021-04-07" version="1">MRAVVLVGGMGTRLRPLTLSVPKQMLPVGGRPMIEHVVEHLAVHGVDEVVLALGFRPDAFLAAYPDGRCRGVKLRYAVEAEPLDTAGAVAFAAGEAGVDETFVVCNGDVLTDLDLTELVAFHRRSAALATISLTPVEDPSAFGVVPTDGDGRVLAFIEKPRREEAPTNLINGGTYVLEPEVLERIPPGRRVSIERETFPELAATGRLYALASAASWLDAGTPATYLAANLRHAGDAPRPAGVDPAASVADSVLAPDARVGPGARVERSVLMAGARVEAGAVVTDSLLGPGTLVGSGAAVTELSVLGAGAEVAAGRRLRGAHLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR0</accession>
    <name>A0A7K0JUR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000680">
        <property type="protein sequence ID" value="MST33663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="169"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="30130" checksum="766C6F7DA1178012" modified="2021-04-07" version="1">RRRRLSRRQSGRQRRQRGGQAWVDAKVVGALAALDSSAPAGLLRLSAEVGEFVSTQLALAELDRSKERATRAELRFLRAQISPHFVYNALTAIESYVRSDPDRARELLVAFADFTRYSFAPFRQTTTIADELRLVDLYLDLARARFGDRFSVQLRVAPEVLSVRVPSLILQPVVENALRHGLEPNGHGTLSISVEDADAEAVLSVDDDGVGVEPARMRHLLDGTSGEEGVGLHNVDERLRAVFGEGHGLVVETGKGAGTRVTMRIPKSSTGVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU6</accession>
    <name>A0A7K0JUU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000563">
        <property type="protein sequence ID" value="MST33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="18512" checksum="7401EC07A915C7E5" modified="2021-04-07" version="1" fragment="single">MRAPSRSWRVHRLGTPAEALRLDRVEARPPGPGEARVAVGAIGLNFPDLLVCAGRYQERPDPPFSPGFEAAGTVVEVGPGAPVAVGQQVTVVPELPDGAFQETLTAPGDQLYPVPASMPVTVAAVLHVAYQTAHVALHHRGRLRTGDTLVVTGAAGGVGMAAVQLGRAAGARVVAVVTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV0</accession>
    <name>A0A7K0JUV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000695">
        <property type="protein sequence ID" value="MST33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="14"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="16276" checksum="CA08C1E70DE27BB8" modified="2021-04-07" version="1">MVTTIDGIDGLEAHVGQHLGYSEWHEITQDRVDRFADATDDHQWIHVDVERAKAGPFGGPIAHGYLTLSLAPALLGEILAVRGVAMGVNYGLNRLRFPAPVPVGARLRAGAELVAAERIPGGAQVTLQTTFEVEGATKPSCVAEVVFRYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW3</accession>
    <name>A0A7K0JUW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000702">
        <property type="protein sequence ID" value="MST33728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="75"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="17766" checksum="EF7D3A8BC9A41312" modified="2021-04-07" version="1">MSRRAPGPTGPHTFRAVVIVVVAVAVTVGLLTQLRAGRPSGVAGTTGVSGSAASTTTTVAPSTTTTTAAPRPPSQVRLQVLNGLLTGTLSSQWSAKLHTQQGYITLAPDNTTAQDPTSAIYVIKSGYEAEAAALAKTVGLPASAIVDTVPSSAPIPGIDLQEADLVLVIGQSLASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV21</accession>
    <name>A0A7K0JV21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000725">
        <property type="protein sequence ID" value="MST33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="383" mass="39265" checksum="FC2E8EF79A2C3AF4" modified="2021-04-07" version="1">MSRPHRAVVLGAGAAGLSAANRLAIHAGRGDADLEVVLVDRSTHHVFLPGFVSVLLDGAAADGFRRPLASLVRPGVRVVTGAVEGIDPGGGVVSGEFGELAFDSLVVALGAEVGWPGEAPVEDVTPWTEAGTRRGASLLGRLGPGDRVVVAPATPAYRCPPAVFDLAVRVRRRTGAEVTVAHPWPRPLAPFGEEPAARFEDMLAGAGVRFVGGFQLAEAAPGRLRSQAGAVLDCDAAMVVPPHRSPAAVAASVLAGDGGWMAVGYPGLSHPDFPHVYGVGDVVAPSLRVGMAGTLGVFEGAFVAGRIVEAAGGPPAGPAPRMAAICFVDQETTGSFLHCDFSGPAAGTGPARCTLMPDLPYFRRARRLFAEEWFASTIGGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV24</accession>
    <name>A0A7K0JV24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000734">
        <property type="protein sequence ID" value="MST33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="7403" checksum="28C419F847C2B6F7" modified="2021-04-07" version="1" fragment="single">MSALTVAPAARGLQGELRVPGDKSISHRALLLGALAEGTSRFTGLSTGDDVAHTAAAVAACGAEVERVDDVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV97</accession>
    <name>A0A7K0JV97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000752">
        <property type="protein sequence ID" value="MST33863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="2">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="17852" checksum="694C0196BFC90C85" modified="2021-04-07" version="1">MSGEPEENPAGAGSTGRPAPAGADRTARVGAVQRDDATAAFFDGTAAGTFLLRRCPTGHWSEPAAEVCGGCGRTDLNWAPASGAASLVSWSVVPGPDGAPSSVLVIGELAEGPWWWSQLTDADPDQLAVGRPLRIVFARPTGDGGGGGGTEAVPLFALEADGQPRPPARLATLRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE3</accession>
    <name>A0A7K0JVE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_14435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000768">
        <property type="protein sequence ID" value="MST33911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="7517" checksum="0DE2F7D7C0A8EC24" modified="2021-04-07" version="1">AAVIADPARPGLGRPGVAAVDGTGAAVLVLVSCDPASLGRDAGLLTAGGWALEAVTVVDAFPHTPHIECVSRFVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG1</accession>
    <name>A0A7K0JVG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000616">
        <property type="protein sequence ID" value="MST33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="28811" checksum="5AA3D592BAE42644" modified="2021-04-07" version="1">MTDEPSPYLHGHHDSVLQSHRWRTAANSCGYLLDHLRPGMTLLDVGCGPGTITVDLAAAVAPGEVVAVDRAAGILAEAQATAAAGGVGTVSFEVADVLALPYADGRFDVVHAHQVLQHLADPVAALREMRRVCRPGGVVAARDGDYGGFLWTPPDPVLDQWRDLYVAVARAIGGDPLGGRRLLAWARQAGFTDIRASASTWVYATSNERQWWGRSWADRATRSAFADAARSHGLATDAELAAIADAWRRWAESDTGWIVIPSGEILCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK7</accession>
    <name>A0A7K0JVK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid carrier-dependent glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000799">
        <property type="protein sequence ID" value="MST33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="593" mass="64549" checksum="CAF1DEB3DE159671" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM5</accession>
    <name>A0A7K0JVM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000808">
        <property type="protein sequence ID" value="MST34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="8469" checksum="67EFE8046BA4C3C2" modified="2021-04-07" version="1" fragment="single">MAGKSELEQRVQAHLGRHHGVISLGQALDLGLSARQVRRRVAAGVWVPLQRGVYTTAGIEPSWATQLAAALCAAGPEAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR0</accession>
    <name>A0A7K0JVR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000820">
        <property type="protein sequence ID" value="MST34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="214" mass="23495" checksum="54077C6C782EED5A" modified="2021-04-07" version="1">MTTRRLGSAEAAELSRAERDIRARLGDRPFDFRAMAAISNIYRAATTVRNHMEQRVLGEYDLSWSAFTVMWVLWIWGEQETRHVATETGTTKGTLTGVLKTLESRRLVLRSVHPDDGRRVLVRLSPRGLAIIEEVFPRFNGEETFAASTLTPAEQDQLAHLLRKVSARIEGAGVAPVEAAAGRDPGAGGDAGGVDTTAPAPYVRRQTTTRPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR1</accession>
    <name>A0A7K0JVR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000820">
        <property type="protein sequence ID" value="MST34036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="299" mass="32177" checksum="88150044B8CB47DE" modified="2021-04-07" version="1">MTTETRRILLDGAVVEALADGDTLVAPDGRRVAADDAVHLPPVEPTKIICCHLNHVSRVREFGGTLPPAPTYFHKPVSSLNAHGGAVVRPANCHWLNYEGEVAIVIGERCRNVAYDDAAAVIAGYTIANDFGLHDFRDTDAGSMLRVKGADTLCPLGPGLVRGWDWQAKSIRTLVNGEVRQDGSTDEMAWDMHYLVADITRLITLVPGDVILSGTPAMSRPVEPGDVVTVEVEGLGALTNHVVAGPEPVSDHVGAQPTDTDEVRSTAQGGDWPPRGTRRPAPTPRDQLPYPAIRPRFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR7</accession>
    <name>A0A7K0JVR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000825">
        <property type="protein sequence ID" value="MST34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="19442" checksum="365F0F9408092A91" modified="2021-04-07" version="1">DGGYREASLAVWAALVAAEVDAAAAATGRHPGPDVLEGHTLAWYEHGRRLAAPGVVRALDTLHAAARSVHARFEDEDLDVLLSPTLPTLPPPLGTWDPAREVDAAWYYEQSAVGDLESTTSSYNCSGQPAVSLPLHQSAAGLPIGIHLAARAGREDLLLSLAAELEQAFPWSHRHPPVWAGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT2</accession>
    <name>A0A7K0JVT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000805">
        <property type="protein sequence ID" value="MST34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="33516" checksum="54433C3943D5DF59" modified="2021-04-07" version="1">MALSPQVAEVAFPLAAVVSIVASGLAVSRLERVAGRLGFSEAALGLLVALAADSPEITSAVSALLHGHADIGAGVVLGSNVFNLAALLGLAALVAGRLRLHRRVAALDGVAATWVAAVCVVVVATPLGPAPGLALVAAGVGPYIALTVLSERTLERLRIPPAAADWCRQAVAEEVADFAPAVDRTPYRPRDAAVAAGSLAVVIAASTVMERTAQSLGARWHLSGLVVGGVVLAGVTSLPNVVGAIHLARRGRGSAVLSEALNSNMLNVVAGLFVPGVIIGLGPSGAGTLVAVWYAALTVVSVLLVWWGRGLRRPAGIVIIAGYLAFVGAAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU2</accession>
    <name>A0A7K0JVU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_15180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000830">
        <property type="protein sequence ID" value="MST34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="261" mass="26386" checksum="D94F67BD90A92562" modified="2021-04-07" version="1">MSSDAVTTSGVEGIRPGRDATTGVHAPPGGGGPRRRREGPEPEPRSYYGQPILNKPVWESPDIPGYFFLGGLAGAGAAIGAAAQLTGRRRLARVSKLGAATAGHLSLVGLIHDLGRRGRFLNMLRVFKVTSPMSVGSWLLAGFVPAATVSAACDVTGFLPAVGALATAGAATLGPPVAAYTGALVADTAVPAWHDGHRLMPLVFAASGVSAAGGLALLAAPIDEVRPARALGAAGALAEVGLSKVMEKRMGMSCRRTSAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU4</accession>
    <name>A0A7K0JVU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000832">
        <property type="protein sequence ID" value="MST34063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="14948" checksum="D3F641C48A77DD6C" modified="2021-04-07" version="1" fragment="single">MTLTQLEAFVLVARLGSVKAAANALGVSEPAVSGALAALRQQLGDPLVVRRGNGMSLTPGGQRVVGIASQMVNLAAEAESAVRQANGAPALVRVVATATVAEFVVPPLLAAFGARATAVSTTVGVSEAGEAAALLHERLADVCLGPRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX0</accession>
    <name>A0A7K0JVX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytochrome sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000847">
        <property type="protein sequence ID" value="MST34091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="23670" checksum="42F96DD5A63791B4" modified="2021-04-07" version="1">TQPVDGSFAGAALLTHLHWDHVQGLPFFPAADRAGARFDIYGPAQDDGSLAEVLDQLVRPPFFPVTVGELRGRITVHDVAEADFAVGRALVSARLVPHRGRTLGYRVSWDGAVVTYISDLQAPADLASVPAAVLELAAGADVLILDAQYTAEEFVEKATWGHCTVGYAVAVAAAAGVGTLALFHHDPEHDDDRIDRLLAEARLAAGSGSGGPDVVAAYEGLVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW86</accession>
    <name>A0A7K0JW86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N(G),N(G)-dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000733">
        <property type="protein sequence ID" value="MST33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033199">
        <property type="entry name" value="DDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737">
        <property type="entry name" value="PTHR12737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="28099" checksum="A04CBED8EBBB98CA" modified="2021-04-07" version="1">MGHDRVVSRVALVRRPSSQLDAGIVTHLERRAVDLGRATEQWDAYVDALRDAGWSTVEVPAADDCPDGVFVEDTMVVHRSVAVIGRPAAPTRRGEIAGAAATVEELGYAVARIRAPGTLDGGDVLKIGDTLYVGRGGRTDPEAVRQLRAVLGPVGVSVVAVPVRSVLHLKSAVTALPDGTVIGYPPVVDEPALWPRFVPMPEESGSHVVDLGDGRVLMAASAPRSAERVADLGWEPVLVDIGEFEKLEGCVTCLSVRLRDCPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC1</accession>
    <name>A0A7K0JWC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000749">
        <property type="protein sequence ID" value="MST33854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="7993" checksum="F67F05A6E26D6F32" modified="2021-04-07" version="1">MGAFAAGAGAEDAAVPEIDGTGPPGDETAAAPAPGGQLIGDPDDGEDPDDRSRLLAGGVEDDEAAPSPEEAAMEVLDDDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG7</accession>
    <name>A0A7K0JWG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000931">
        <property type="protein sequence ID" value="MST34291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="11526" checksum="5FDB419CC32F02D9" modified="2021-04-07" version="1">MTTLTPPSFRLAERLPSADGIGLCVACDGQGTYLVVSLVGRSGPCWICVPATRRALECVRRRRASPWALVHHSATGTVTVYRTLLDGSLRESTMLCAELPTGAAVLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG9</accession>
    <name>A0A7K0JWG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000928">
        <property type="protein sequence ID" value="MST34283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8738" checksum="A478B5C0EF9ED3F6" modified="2021-04-07" version="1">MLWRAVRPHLPRSHHASPSTFVLNRGGGQGADALGPAMLPGPARDSLVDAYETSDEASREAGVSNDSQGRPSTSSHAPTFRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI2</accession>
    <name>A0A7K0JWI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000910">
        <property type="protein sequence ID" value="MST34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7048" checksum="D241B0CF614CB45E" modified="2021-04-07" version="1">MLNIFGEHLTLPDIAFRPRAAKQVQAAGMSWTVGSRSAAGDCLGTYGTNPTRVGGGRPTSSPDRWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL0</accession>
    <name>A0A7K0JWL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">GHK86_16610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000950">
        <property type="protein sequence ID" value="MST34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="27117" checksum="DBB56AF5E7E0E184" modified="2021-04-07" version="1">MPLFQVENLHVRVEGAEILRGVDLTVGTGEVHALMGPNGSGKSTLANTLLGNPAYEVTEGRILFQGEDITDWPTEIRGKAGIFLAFQYPEELPGVPVVQFLRQALSARKGIDLSVLELRLSIMEWMKRLDMDPSFGDRFLNEGFSGGEKKRNEILQMAILEPDLAILDETDSGLDIDALGVVASGIAEVRRSRPELGVLLVTHYQRILDRVTPDVVHLLVDGRVVTSGGPDLAKKLEAEGYEAWRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT7</accession>
    <name>A0A7K0JWT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000991">
        <property type="protein sequence ID" value="MST34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="362" mass="38846" checksum="BD7AF06553EEA3AA" modified="2021-04-07" version="1">MRIDQLLPVLGGHDAIAAHVLQVRTALRAAGFESDIYADVVDARHAGVRPWLDGPGRISPDRVVLYHASTHAPLAPWLVQRGRRGERIVVDYHNVTPSAYFRRWLPDAAEEMDAARAELAALAPVTGLALADSGFNEAELVELGFRATATAPLLVDLAAYHQPPDEPTLARLRRQRERGGAAWLFVGRIAPNKCQHDLLAAFAVYRRLMDPAARLTLVGGATAPAYLAAIERMVDELDLEPAVEIASGVGHAELLAHFATADAFVCLSEHEGFCVPLLEAMELGLPIVAHPAAAVPETVGDAAVLVADKDPLTVATAVAELLADEPRRLALVEAGRRRARRFELATTSAELLGHLTAHLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW1</accession>
    <name>A0A7K0JWW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001004">
        <property type="protein sequence ID" value="MST34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="167" mass="18731" checksum="81778D215A7360BC" modified="2021-04-07" version="1">MARAARKQKPEEEPAPTPRAAVKGAAARGTAARGRIEPPPSEPSSGKKPPLRQRMSEQIMKIGFLRRRYVKRLIRHIDKSKQKGKRLPPELMDLARFLSQVPKEQRAEKLEEAILAQQSGAEEAYNRDLRRAAANQQRRSGKGAGGYRPGAPPRSMQQGPRQSKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX24</accession>
    <name>A0A7K0JX24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hisI</name>
        <name evidence="9" type="ORF">GHK86_17480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01001043">
        <property type="protein sequence ID" value="MST34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="126" mass="13760" checksum="70D155362EB3F2ED" modified="2021-04-07" version="1">MTAVPPVATPIAWTPEQLAEVRFNADGLVPAIVQEHGTGLVLMLAWMSRATLEETLSGGRTVFWSRSRQERWRKGDGSGDRQWVREAYYDCDGDTLLFVVEQEGAGACHTGTRSCFARAFGAPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA4</accession>
    <name>A0A7K0JXA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001085">
        <property type="protein sequence ID" value="MST34588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="18125" checksum="2E263304A8FA1706" modified="2021-04-07" version="1">GRKIGAEHRPEIARHRPRSRPLTSTLLGAPAPALAGTTLTGHRHLSLTSFAGKWLLVDFSASWCVDCREELPQLKAFARTAKHYDAAVLTVEEDPSDAPAMARWLAAEGAHWPAIQDPAATATFGVTGIPTVYLVDPDGIIVGYYPSGISPTSLDSLITSAIRGSGGNGGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB8</accession>
    <name>A0A7K0JXB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme exporter protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_17565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001052">
        <property type="protein sequence ID" value="MST34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="197" mass="21589" checksum="721C376737311461" modified="2021-04-07" version="1" fragment="single">MTLPSRRSSTSSRATRIVGGFTLLGVVALLVLGLVVSPPDPIQGETVRLIYVHPASATMCYVGFAICALASIAYLWPRTRNMRWDRLAGASAEVGVAFCVACLVSGSIWGRYSWGVWWTWDARLTLTALLLVVFLGYLALRRTGGDPAGRAKRAAITALCCFIVVPIDHEATNWWVTLHQKDTLFRIGKAPLIQGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC7</accession>
    <name>A0A7K0JXC7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheS</name>
        <name evidence="10" type="ORF">GHK86_17615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001055">
        <property type="protein sequence ID" value="MST34532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="45"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="274" mass="30037" checksum="8B7594F51D2846B8" modified="2021-04-07" version="1">LEAADRAARLAADRLDLTEAALLGPRAWPRGLPDRGHLHLVTQTRDELEDTFVGMGFTVAEGPEAETDWYNFEALNMPPAHPARSMWDTLYLDLGDPESILLRTHTSPVQVRLLEAQAPPIYAVAPGRVYRKETPDARHLAVFHQIEGLVLDEGISFGDLAGTIETFTQAYFGAGMHARLRPSFFPFTEPSAEFDITCPICAGAGCRTCSHSGWIELGGCGMVDPNVLAAVGVDAERWTGFAFGFGIDRLAMIRVGLGDVRALTENDLRFLHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH2</accession>
    <name>A0A7K0JXH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001122">
        <property type="protein sequence ID" value="MST34646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="22843" checksum="AE3F3C147962F328" modified="2021-04-07" version="1">MDTDLVDQVIDVARRIVASGAISANGHGNVSLRVPGGDEMYFTGGASLRDHPADLVARVGLDGTLREGQLPPIQGAVVAMHTALYADRADVGCVMHTHSPYATAYAVANRPIGCWIEALAMFGLPDGVPVAGYGPRGSDRAVANIRAAVRPGVPAVLLANHGVLVFHRTPELAVLVGGVVEEAAQAGINAGGLGGPVEIPADMRAAALQRAMIFEQKGTVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN6</accession>
    <name>A0A7K0JXN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001173">
        <property type="protein sequence ID" value="MST34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="11218" checksum="F7AC98EE7E6A9AF8" modified="2021-04-07" version="1">MVAVHAWSNPVSPYERDDGAQEDAQKVLDDAVDGFAPEGVELRRVLAKGRPAVVLVDEAKGADLLVVGTRGHGPVGAAMGSVSTRCLRHAVCPVVVVPDHRAATVAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV5</accession>
    <name>A0A7K0JXV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001213">
        <property type="protein sequence ID" value="MST34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="17060" checksum="8B29597AAFDD3DA7" modified="2021-04-07" version="1">MFCNQCGHRNPEGSNFCSSCGAVLDRPGDLEPVTVTLAPVEGAGEAADEELVVSLSDVPPDAGLLVVKRGPNLGSRYLLGEGITTIGRHPDSGIFLDDVTVSRRHAEVEYHPGGDFAVRDVGSLNGTYLNRERIEAATLAHGDELQVGLFRLLFLTEASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW9</accession>
    <name>A0A7K0JXW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001213">
        <property type="protein sequence ID" value="MST34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13652" checksum="F0AA39BE13397755" modified="2021-04-07" version="1" fragment="single">MAERTHLTIGEVLTLLREEFPDVSISKIRFLESQGLVDPERTPSGYRKFYDHDVERLRWILQQQREHFLPLKVIRGRLNEQRQQGGDGRDEPPGTAGATATAEHNGNGPGAHAGGPGDAGGTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX9</accession>
    <name>A0A7K0JXX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001233">
        <property type="protein sequence ID" value="MST34818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="25144" checksum="F0911076C8550674" modified="2021-04-07" version="1">MARILHAVAAERDRRLGDPRAAAVPVEAMLDPAHLATLGRERARAGRSGSPRGAARSGDTVAVVAQDPDGQAVSIVQSVFHAFGAGMLEARTGIIIHNRGALFSLDPGSANHLQPGKRPLHTLMPVMLSADSGRRAVAGTMGGRAQPQVHTHLLAGIVRGTSPTEVVGAPRWVVGGLDAGSVDDEIFVEGTVPAATRRALEGSGMALRDLPDLDEAVGHAQVITGEGATVEAAADPRSDGSARVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY4</accession>
    <name>A0A7K0JXY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001229">
        <property type="protein sequence ID" value="MST34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="22594" checksum="32E8A466F357F3BF" modified="2021-04-07" version="1" fragment="single">MSTRIAPGVIEIDTLLGGWERVTAGYLIEGPAPVLVETGSQSSVPATLAALEALGVGPADLAGIAVTHIHLDHAGGVGDLARVFPRATIYVHQKGARHLADPARLVASAATVYGDLLDTLYGRLDPTPQERIHVLEDGEEVVIGPGRALTTIDSPGHAKHHLALHDSESGLLFAGDAVGVRLPDAGVLWPATPPADFDLELACRSIGRFRDRRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY13</accession>
    <name>A0A7K0JY13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000991">
        <property type="protein sequence ID" value="MST34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="318" mass="34002" checksum="51899666C26EE883" modified="2021-04-07" version="1" fragment="single">MRIAQYLPDLVPHDAISDHTRRLHAALVAAGHEASIHAAHVDRRLRREAKRWDPGAPPPPDGIALYHASTGSPIAGWIGRHAAGGTRLALDYHNITPARYFDRWDPRAAARSREARRELAALAPWAELAVADSAYNEAELSAAGFARTGTCPLLIDVDAFRQPPDAGTLERLRSERARGGASWLFVGRLAPNKCQHDLIAAFAVYRRLHDPAARLTLVGNPSSLLYQRSLEALAADLGVEGAVSMLSGVPHAELLAHFATADALVCLSEHEGFCAPLLEAMVVGTPIVALAATAVPETVGDAGVLLERKDPLVVAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY17</accession>
    <name>A0A7K0JY17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001212">
        <property type="protein sequence ID" value="MST34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14573" checksum="689B291334C970DD" modified="2021-04-07" version="1" fragment="single">MDRLERLVNLVAALLDADQPLTRAELRTRVGGYSADEDAFRRNFERDKETLRQMGLPLVAEALEGERAEEQIGYRIDREAYELPDPGLTEEELTALRIAASAVRLDGPWADTASRDALRKLAATAPAPGGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY66</accession>
    <name>A0A7K0JY66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001022">
        <property type="protein sequence ID" value="MST34469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="197" mass="20541" checksum="6EE92DD83F13E321" modified="2021-04-07" version="1">DVAGDWWEVDRLADRRVLIGVGDAAGHGVDAVTDMCELRHGARALAAVVDDPATLLSDLNRRLADTPGRFATAVYAVVDPDTGQVEWATAGHVPPIHLAADGTVTVLGGTGPPLGSPLGAVVPKRSFTLAPGDTLILYSDGVVERREVDLGTGIDALVRTVGAHGLEPVATLADVIIAEHCEARIDDCCVLVTRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY70</accession>
    <name>A0A7K0JY70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001277">
        <property type="protein sequence ID" value="MST34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="32209" checksum="B71453E0690B5CC6" modified="2021-04-07" version="1">MMDLRQLQALTAIADTGSFSAAAASLHTVQSNVSSHIARLERELGAQLVDRQAGQLTEEGQAVAERARRVADELDAIVADLAALRAEVVGTVRLGVIGTTARWLTPLLLEALAGAHPRVHLVVGEGTSTMLEPQVATGAHEIAVVNLPQAFPDLTATALFDEDLILVVPPDHTLADRARVQLADLDGLELLLPASGTTYRQELDEAARDAGVALVPRAELDGVRLMASLTARGFGPSILPATTAAEGLDGFVRITVGGLPRRRVGAVVRRRARLSAPARAVLDILREVVERRADEQYGIHRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY72</accession>
    <name>A0A7K0JY72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_19580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001299">
        <property type="protein sequence ID" value="MST34915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="11739" checksum="74CA694AC008DEA0" modified="2021-04-07" version="1">ALRPQWREASESLGAGSWAYWRHVGAPILAPSVLGAMLLLFGFGLSAYATAEALTSGSIALTSIQIGSFLNGNVIAGQANVGKALGFGMVLVASVSMVVYVLLQRRVSKWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA1</accession>
    <name>A0A7K0JYA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001043">
        <property type="protein sequence ID" value="MST34504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="11859" checksum="1A5B30BB34ABC60E" modified="2021-04-07" version="1">MVETAKQGIQMLADRVLVQIPRAEGERKSRAGILIPATAQVARRLTWAEVVAVGPHVRAVKPGDQVLFNPEDRFEVEVQGEDYLILRERDIHAVASERVADGTGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB0</accession>
    <name>A0A7K0JYB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmH</name>
        <name evidence="7" type="ORF">GHK86_19745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001320">
        <property type="protein sequence ID" value="MST34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="44" mass="5209" checksum="9F2C3849BCF71469" modified="2021-04-07" version="1">MKRTYQPNNRKRAKKHGFRKRMSTRAGRAVLKARRLKGRARLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF2</accession>
    <name>A0A7K0JYF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Error-prone DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001069">
        <property type="protein sequence ID" value="MST34554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17468" checksum="2B0AF9E4F267F931" modified="2021-04-07" version="1">VGGDARHRVRSARLPGLVTGAEAPPLPGMTPAEANRADLWATGLSPDHYPTEFVRDALTRAGVVTAAGLAGVAHGDRVRVAGVVTHRQRPATAAGITFLNLEDETGLVNIVCHRGVWSRYRRVARAASALVVGGRLERVDGVVNILAERIEALAIGAALRSRDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI4</accession>
    <name>A0A7K0JYI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001360">
        <property type="protein sequence ID" value="MST35010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="200"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="50580" checksum="EFC527EC9FDAA364" modified="2021-04-07" version="1">MADLLLESWLAQQRGRITETLFEFLRIPSISADPEHAGDVRRSAEFVAELLRDAGLEHVKLIETARGAGLPAVYGDWLHAGEDAPTVLVYGHHDVQPVDPLEEWTSGPFEPVIVDGECRARGAIDDKGQVLYEIEAARGLLAERGALPVNLKFLVEGEEEIGSVHFQQLLLEREEQLACDVVVVSDTGMIAPDVPSSTVSMRGLVGFDVALRTASIDLHSGMWGGTVPNAARLAAELAAALHDGDHRVTIPGFYDQVRPLSAEEEASLAAQPFDEQEFRAQAGHVAYLEGEAGFSPLARIGVRPTAEVVGIHGGYAGPGIKTIVPATAGLKVALRLVPDQRPDEIEAAFRAWVQSRLPTGVEAVVTGEGGVAPAVTPVDHPAMQALAETIEAVWGKRPLWTREGGSGPEEALGRMLIAPVLFLGVGLPDDRIHAPNERMVMDQFWKGLLAAAELQERLGRLRFPKRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW3</accession>
    <name>A0A7K0JYW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001469">
        <property type="protein sequence ID" value="MST35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9129" checksum="E93D07938441DC57" modified="2021-04-07" version="1" fragment="single">MHEPFVPGPTLTALVVRPGPLVGTFHRAGVSGWYQLLRPLSRWSVDHLDVRVAVSEAAAATARAAFGGDYTVLWNGIDVEQFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY7</accession>
    <name>A0A7K0JYY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mur_ligase_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001468">
        <property type="protein sequence ID" value="MST35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="87"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="204" mass="20567" checksum="C08CA40D03631411" modified="2021-04-07" version="1" fragment="single">GGAGSGRRVPCRTIAGTAPPTSAAPEASLLSTLPTRTRTAVRVGGAVGDLSRRMGLGAGSTVGGRAILALDPGAIRRLAAGRRSALVSGTNGKTTTTSLLRAAVGTTGPVVTNLQGANLPFGIAAALAEGGAADTAVLEVDEAWFGQVVADTDPAAVVLLNLSRDQLDRNSEVRTLAGTWRRALADRPRTVVVANADDPLVVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ51</accession>
    <name>A0A7K0JZ51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03619 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001247">
        <property type="protein sequence ID" value="MST34839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="276" mass="30402" checksum="DA3426CE90A63B77" modified="2021-04-07" version="1">MDFGVAIFPTHDGMDPASVARLVEARGHESLFFPEHTHIPADRRSPYPGGGDLPRRYVHTYDLFVAMTAAVTATSRLRVGSGICLLVQRDPIVTAKEVASVDALSGGRVEFGVGAGWNREEMANHGTDPRRRMRLLQERVEAMKVIWTQDEASYHGEFVDFDRIWSWPKPAQRPHPPVLVGGNGPTVTDRVRAFGDGWMPNYAAEGILERARRLQGDADRAIELMVMGVPADARVIAGFEDAGFRRVVHWLPSAGQGRVERALDAFEAAVAEAHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB6</accession>
    <name>A0A7K0JZB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001576">
        <property type="protein sequence ID" value="MST35277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8897" checksum="8651F90AAEAF4996" modified="2021-04-07" version="1" fragment="single">MDETRAPAADDLDTIVDTVLEASRALLAVAARCLNDVAGDVTLIQYRSLVRLCSHGPQSLATLAEAVGVSRSTESRLCERLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF9</accession>
    <name>A0A7K0JZF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001658">
        <property type="protein sequence ID" value="MST35355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="26484" checksum="6863E8F9B93EB1BB" modified="2021-04-07" version="1">RRAESRAGEVFPQPLPPACAVTPMPPIVAASGAAPHYTAPRLDGTRPGTYWFNLERPTAGTGWDLEGVAFHEAVPGHHFQLSRIQLLGDLPAFQRQRSYTVFAEGWGLYAEQLAEEMGLYSGTQALLGAMANALMRGARLVVDTGMHALGWSRAEALAYFVEHVPMPESFLANEIDRYIFWPGQALGYLTGKREIIRLRDRARAALGPAFSLPAFHAAVLDHGSLPLPVLDRWIATWIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZK7</accession>
    <name>A0A7K0JZK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001624">
        <property type="protein sequence ID" value="MST35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="26200" checksum="802EE213CED082C0" modified="2021-04-07" version="1" fragment="single">PPPASVLAALADADAGGATRGYPPSVGTAALREAIAAWLAGTFGVTTVPTDAIGACIGTKELVATTPQWLRLRDPSRDTVLYPAVSYPTYAMGAELAGLRAVPVPLDERWRLDLAAVDPADAERALLLWVNSPGNPAGGLDDLDAAAAWGRRHGVPVFSDECYVELTWDGPPRTILAAGLDGVVAVHSLSKRSNLAGLRVGWYAGDPELVGYLREVRKHVGLMVPGPAQRAAVAALADTAHAAAQRERYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZR2</accession>
    <name>A0A7K0JZR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF427 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001403">
        <property type="protein sequence ID" value="MST35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="149"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="29769" checksum="C814985E082A56FB" modified="2021-04-07" version="1">MTASRRHPVPDDELTYEPSERWVRATIGDTTVVDCRAPVLVWEPGSPVPSYAFPAGDVRTDLLEAVAPEADHGHVGTADWYDLVLEGRRYDRLAWTWAAPQLAGLVTFDWMGREAPGVEHWYEEDEEIFRHPRDPYKRVDPIPSSRHVVVALGGRVLADTRRPVLLYETRLPTRYYVPAEDVDFSALEATDLRTRCPYKGVARYWSVRGEPTGRNIVWSYPDPVPAAAAITDLVAFYNEVVDITVDGVPQPRPVSEFSAGLAAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0F1</accession>
    <name>A0A7K0K0F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FliI/YscN family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001572">
        <property type="protein sequence ID" value="MST35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="251" mass="26803" checksum="D133912FCC20AA08" modified="2021-04-07" version="1" fragment="single">PLRRSPVDRPLSLGVRVLDTLVPCGRGQRLGIFAGSGVGKSTLLSMIARGTTADVSVLALVGERGREVGEFLTHDLGAEGLARSVVVVATGDEPALLRRRAALTATRIAEGFRDEGRDVVLMMDSVTRFCMAQREIGLSAGEPPATRGYPPSVFSLLPRLLERAGTSEHGSITGLYTVLVDGDDMNEPIGDAARSILDGHIVLSRRLATAGHYPCVDVLESVSRVAPRVTDDQQRELATRLRSLLAAKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMT7</accession>
    <name>A0A7K0JMT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="17368" checksum="41684396A34B11AF" modified="2021-04-07" version="1">MLNTLKKRLGRKEDEGFTLIELMVVVLIIAILMAIAIPTFLSARGNAQAKAAESNLRNATTDEQTYLTGPGQGSTYGTSADLTSNSVDNSLTFVSTIPSSTTPSPSTIGIAISGSATDPQVALVDQGADGKWYEVFDNNGSVTYAVSATAPTAFPTAALGSTTWSGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN27</accession>
    <name>A0A7K0JN27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000049">
        <property type="protein sequence ID" value="MST31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="10151" checksum="2F40A59B9E48CC1E" modified="2021-04-07" version="1" fragment="single">MPLSPGQEAVRRPVVRDPRHQRVGRSLVVAAPGHGRSPLTGGTAVAHRNAHRGSDGASSPSPPPPSPSRPPGRLARRVAVGVVVAALVAFAGLGVASLVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN30</accession>
    <name>A0A7K0JN30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate formiminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000045">
        <property type="protein sequence ID" value="MST31355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="SSF55116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="65" mass="6644" checksum="38ADFBF9A3122A24" modified="2021-04-07" version="1" fragment="single">MLECVINVSEGRDTAFLAHLRAAAGAACLDVHSDADHHRSVFTLAGEDAAVEAAARRLTAAAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN45</accession>
    <name>A0A7K0JN45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000056">
        <property type="protein sequence ID" value="MST31390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029502945" evidence="1">
        <location>
            <begin position="35"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="99"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="609" mass="64340" checksum="E873C672E864B30D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN54</accession>
    <name>A0A7K0JN54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000029">
        <property type="protein sequence ID" value="MST31281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="531" mass="58559" checksum="6C313F411D4D7B60" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN83</accession>
    <name>A0A7K0JN83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000063">
        <property type="protein sequence ID" value="MST31416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="18152" checksum="359C8357BC4BA051" modified="2021-04-07" version="1">MVDQFRSRDQQGFAIADDERATAGLHDVVIRRLFAAALTVEEVRREPRRSVGEVDGLLAEVVGGLDDTIREVRTAIFERQRRRVAGLRDAVLATIHEATASLGFEPYLHYEAPPERQSPTPWHQPSPRCCGRRSRARRDAATRTGSTSPSRSGTAGCASASPTTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK5</accession>
    <name>A0A7K0JNK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="6589" checksum="45C0C61DF9CFBE0A" modified="2021-04-07" version="1">MATALAVWEFCDGPFREPTGEFSARRGAYRAIYRLVRDDSAVHVVRLEHPADVDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK8</accession>
    <name>A0A7K0JNK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000092">
        <property type="protein sequence ID" value="MST31535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="16325" checksum="5F09AD08BB1E94F8" modified="2021-04-07" version="1">GDREPADLRARIADTFARLATAFDNDARLAAVADIRQIAAERLEATPDGVPPVTLHSNPGPEHTFVDPATGAFTGLIDFGDSYRSHAAFDLRPWADGDDAAAVLDGYQTAGQLPPDFEHVRHTTLLIDALARAARGRTSPQQLAATLDRLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL6</accession>
    <name>A0A7K0JNL6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">argF</name>
        <name evidence="10" type="ORF">GHK86_02005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="WJHE01000085">
        <property type="protein sequence ID" value="MST31503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="157"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="37195" checksum="9FCC6ED3F59B665B" modified="2021-04-07" version="1">MAVNLRHRNFLKELDFTGEELRYLVDLGAALKAAKAGGYERRTLTGRNIALIFEKTSTRTRSAFEVAAHDQGAHVTYLGPDESQIGAKESVRDTARVLGRMFDGIEYRGAKQDDIEVLGRDAGVPVWNGLTDEWHPTQMLADILTMQEHSTERLADVAYCYLGDARNNTARSLLVTGALLGMDVRVAAPRELWPDEDLRVTADRLAKESEARILVTTDVEQAVSGAGFVYTDVWLSMGEPPEEWSRRIDLLRPYQVNRAVLAATGNRHVRFMHCLPALHNRETRTGERLYRQTGLDALEVTEDVFESPASIVFDQAENRLHTIKAVMVATLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM4</accession>
    <name>A0A7K0JNM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000099">
        <property type="protein sequence ID" value="MST31572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="36499" checksum="22982A8317D23AA7" modified="2021-04-07" version="1">MAGRAVKIAEVASAAGVGVGTVSRVLNGSPQVRDETRKRVLAVIQQLGYRPSRLASGLALGATRSVAVLVPFMTRPSVVGRLAGIVAVLDAEGFDCVVCNIETAEQRDRHLRGFADLHRVDGMLVVSIPLHQGQVDAIAATGLPLVLVDADAPGVPRVVIDNVAGGMLATDHLLALGHRRIAFIGDTSRRGMGFLSNARRLEGYRRALRAAGVTPAPELVRRGPHGGAVAGSIALDLLQRDDAPTAIFAASDTQAAGVLQAAKKVGCRVPRDLSVIGFDDVETAELLGLSTIRQPLARSGELGARMLCSLIRGDPVPAGRTTLPLELVRRTSTAELVTRSRAPTLVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS2</accession>
    <name>A0A7K0JNS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000087">
        <property type="protein sequence ID" value="MST31511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13244" checksum="9F70D0DA938F2243" modified="2021-04-07" version="1">MAVTNGAGHLASLRALVQEAAARLHPGWVWADRLSAALSLENGSEQLPVAFDDVRCVRPARPGRAVVTDADVVAGYVASVGDVYGRDLQDDWDRLVDAVRSRAARIIEAEGSLTVEGDVGAFLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP04</accession>
    <name>A0A7K0JP04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K(+)-transporting ATPase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdpF</name>
        <name evidence="2" type="ORF">GHK86_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000119">
        <property type="protein sequence ID" value="MST31702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="29" mass="3235" checksum="B858E56C93F25BB7" modified="2021-04-07" version="1">MSAVQLAALIISVLLVIFLVYAMLFPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP08</accession>
    <name>A0A7K0JP08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000119">
        <property type="protein sequence ID" value="MST31698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="63"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="21716" checksum="EA89AFD9FFFF8821" modified="2021-04-07" version="1">MAGGERWRVDRQAPDAAGIRRRRRRPHHRPAPWLRRAVASLPRLAAAWDREEGGGWVTAGARRILVVEDDTFLRRVVELSLTAHGYQVDQAGTGADALRLITAGPDLVVLDLGLPDVDGIDLIVGLHDLVGAPILVVSARDRRTTAATALAAGAAGYLAKPFSTGELLAEVSALVAGGDPVAGGGRDGGSEATGSCSSGQAPRAMRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP22</accession>
    <name>A0A7K0JP22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046249">
        <property type="entry name" value="DUF6282"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19799">
        <property type="entry name" value="DUF6282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="311" mass="33513" checksum="B439DDBAABF45A6E" modified="2021-04-07" version="1">MTEAVHPRPSDRARELVAGAVDLHVHVAPDVMRRRITDFDLARRHVDEGLGGFVLKSHYVPTAERAASVASAVPGAEVYGAITLNGSVGGINPVAVEIAAREGARIVWMPTVDSHNQRTCSASDPEGAKPPMWAQLQEELQERGIAAPPIPVVNGGGEVLPEVIDVLRIIARYDLILATGHLGRDEIMAVVRAANDEGVQRIIVTHPEFTSQRLSGADQRELAERGAFLERCFTTPYTGKVEWGEMLANIRTAGVANSFLSSDLGQPFNPPVEDGLALMAEHLMGAGFDLDEVRLMTVENTKKLVTPKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK7</accession>
    <name>A0A7K0JPK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000150">
        <property type="protein sequence ID" value="MST31827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8258" checksum="30F445DBC22EA715" modified="2021-04-07" version="1">MEGTELEILVGVEAVGSDGGVILTTPALDRVSVVMLDRRPIPVLPLPTLQAVLEATGRRERAAMVREALGRDAPGPPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM1</accession>
    <name>A0A7K0JPM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000172">
        <property type="protein sequence ID" value="MST31906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="4"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="454" mass="48724" checksum="54D0723C77BB981C" modified="2021-04-07" version="1">MAIYAVVDPATGETIKEYPTASDDDLRGAIQRADDAHRTWGATVADRAALIRRVGELHTERRDQLAAIITREMGKPVEQALGEVDFAAAIYEFYADNAEKIMADEPIELLAGEGSAVVRRSSVGVLLGIMPWNFPYYQVARFAGPNLVIGNTILLKHAPQCPESAEAMQQIFDDAGYPSGAYENIRASNEQIEWVIADPRVRGVSVTGSERAGAAVAAIAGRNLKKVVLELGGSDPFIVLSTDDLDKVVEDAVAARLDNAGQSCNAAKRFIVADALYEPFLEKFTAALTAVRPGDPHSADTLVGPLSSKTAADRLEDQVNRAVAQGAKVVAGGKRDGNFFEPTILTDVRPDNEAYREEFFGPVAQVYRVGSEDEAVELANDTPFGLGSYLMTTDPEQAARVANKIDAGMVYVNIVGADGAELPFGGVKRSGFGRELGRYGADEFVNKKLIRIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM6</accession>
    <name>A0A7K0JPM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="211" mass="22628" checksum="D3AE4380877FAFEA" modified="2021-04-07" version="1">MPEGVAGCLARRVRTGRHRLARRTAGRRGPKVLTPTAKALPCPSPFVRRPTPARPTPGSPISGPGDLTTSGCTTLGDLPADHAAYSQRVEGRLERLARTLAGQPIRVSPLTVDGLTEFGAREDEPPGSGAARSSYAAEVARRGGARPWPPGRNVPCWCGSGRTYKTCCGPVRWPASEPRRRAREPTRRSPARPEPLRVGHGGDGRGRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR9</accession>
    <name>A0A7K0JPR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="11" type="ORF">GHK86_02285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="453" mass="49252" checksum="92D554C6BA9B9D6C" modified="2021-04-07" version="1">MFESLTDRFDGIFTRLRGKGRLSEADVDEALREIRLALLQADVNLRVVRDFVTRVRDQLVGADLSASLTPGQQVVKVVHDELRAILGGEALRITFAPRPPTVILLAGLQGAGKTTTAGKLAAWFRKQGRQPLLVGADLQRPAAVEQLRILGAEAGVPVFSEASDPVTVASRGLDEARRLGKDVLIVDTAGRLSIDAELMDEVRRVSEVTDPHYTFLVIDAMTGQDAVSTAEAFHKTLALDGVIITKIDGDARGGAALSVKEVVGRPIVFASTGEKQSDFDLFHPDRMADRILGMGDVLSLIEKAEAVVDQAEAERAMSRLQEGSFTLEDFLEQMQQLKKMGPLSGLVGMIPGLPKEIRNAEVDDDAMKPIEAIIHSMTPEERRNPGIINGSRRSRIARGSGTTTAEVNGLLDRFKQMQSYMKGLSNLPGIGRRMSKATAKSGRKSNKKKKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ88</accession>
    <name>A0A7K0JQ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="303" mass="31725" checksum="0105A7A32CF86C14" modified="2021-04-07" version="1">MSDPHPADAATDPGRVEEVRLEATGGVRLAVRVRHLGAPGVPMLLVHGLASNARLWDGVAAELADRGHPVAAVDQRGHGHSDKPDDGYDFGTLTADLLAVIDGLGWRGRPVLAAGQSWGGNVVVELGARHPGAVHALALVDGGTIELSAGFADWPTAEAALTPPQFAGTPRAEFEAALRRAHPDWPESGIEGALGNVEVLADGTVRPWLTLPRHLAILRSLWQHHPLERMAAMQVPVLLVPAGDPRGRASRHETVKREATAAAAAALPTGAVRWIDGDHDLHAQYPAEIAALLVSAADGSAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA5</accession>
    <name>A0A7K0JQA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MmcQ/YjbR family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="117" mass="12491" checksum="7506FE7728AA5851" modified="2021-04-07" version="1">MPGAVEDYPFGEETAVFRVGSAPDGSPGRMFALVSLTGAIGWVNLKLDPALVTELVATHRSVAPGWHMSKRHWVTVTLDAGMDDVLLTELVEHSYALVVAKLPARLRPSQAAVAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA8</accession>
    <name>A0A7K0JQA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029464886" evidence="1">
        <location>
            <begin position="27"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="36810" checksum="5B7C195F59AD3A01" modified="2021-04-07" version="1">MARVQPSRRFAAVGLTAAVLAAANVAATTVGHLEAGSAIVAAVRADQRLPGVSLRFSLGTTAQHLRWMTEDKLPVRAAALYAGAAVSYTLHTADGEPLDTPGLAKSHLIDSAVAYSESGQSLIQIVGVGHRVYGRVRLRGLLWDWRAPAGTLARVRRSLLRENKTVPGITALGRGEWVSVDPAQLESPTTLQSQGDRVITAMREALESATRFQLIRASAGRDEYKATVVARAFLTRLSAALKGLTNPAGGPPFGAVIHGVDRGVPAGTTVVLHLVVLDGRLSEIRVDLGQWSRAPRPTLPLVLRISPAGPVTAPAHSVAIDVTPLAKQLKGGPLAHRWVSGLVAGSFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE9</accession>
    <name>A0A7K0JQE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000225">
        <property type="protein sequence ID" value="MST32151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="22650" checksum="7E3EA93BAD5D9A92" modified="2021-04-07" version="1" fragment="single">MSEQTPQAPAIELVEVTKTFDEGIVRALDGLSLRVERGECVAVTGPSGCGKSTMLHLIAALDRPTSGTIRIAGHDLARLRDRASYRRRHTGLVFQFHNLLPQLSAVGNVEIAMFGSGRPRAERRARAMALLADVDLRGLELRPPTKLSGGERQRVAIARALANEPDLLLADEPTGSLDERSVGRLLDLLGSLRAARPELTVVLVTHDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF2</accession>
    <name>A0A7K0JQF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="14264" checksum="5B41098762FB4697" modified="2021-04-07" version="1">MARRSVISEQILEVMSAGGRHCWTLDDLQGDLVDRGLEPDPSSVFRAVTRLEDAGQVVRVPGDDRRGRFEVAGDHHEHLVCEACGTIEPIACSIVASLADQVRVASGFIVSGHQVVLSGTCGRCAGPADDAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH2</accession>
    <name>A0A7K0JQH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000145">
        <property type="protein sequence ID" value="MST31819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029532291" evidence="1">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="10807" checksum="A0EC61FFA396B16B" modified="2021-04-07" version="1" fragment="single">MSRHIVRGKLVAAAGCALVAGSLVTGSLGTGALAAGAAGVRISARDGGASALGTPVRNLAPSAAFLQACANVGPTVADQRRCVAAALPSFDAARAAEGVGPLALPAGFAAMSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL1</accession>
    <name>A0A7K0JQL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="456" mass="48496" checksum="3A2FF9B70628B7CE" modified="2021-04-07" version="1">MAFLAVTVAVALGGHDPLGALVVLVAGATAGAVKTVLRLRSRARDTAGTARRAFRPSVELIAYLSPVLLLSAAYPIATGRLAGDTVGGVHLTTLLLAASVTVPWLTQSVCLPLYRAVAPQMAAGDTGAIRDRLCEVWPSTFLRCLPVVAAFTLAIELSTGWSLQSIGVYAGLCVLYVAFSQSLVLSILDRRRALWAAGWAAFAACLLAAPALWFLPPVAGVATQLLPLRHHLARMARPVSLERADVAADLVRGLLLGAVLWADKLLLFVRSGPHFAVTTVFVALLPAILVYNYYFVRLAPRFDAMVLALRSSMESEPYGELAVRSRELSSYVERSLGLAACAGAALVLGVTAASELADYRSVPLVASVAIASWMFMMVTLSCYKLDYIGRTRLAQGYGAVHLAICVVAFSVLAVGPGLYACLAAAEGALLLGALRSATEHWQSSEYNLFWRHATAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN0</accession>
    <name>A0A7K0JQN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000257">
        <property type="protein sequence ID" value="MST32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="162"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="593" mass="63941" checksum="3A6311AF97865EA9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW0</accession>
    <name>A0A7K0JQW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="430"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="523" mass="55313" checksum="A6338B1B31FC3C84" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX9</accession>
    <name>A0A7K0JQX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000192">
        <property type="protein sequence ID" value="MST31999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14516" checksum="9DAFE1A60EDBA328" modified="2021-04-07" version="1" fragment="single">MTDIEATVDTGGALLQQLLADAAGAARPWGDAPLSQRAGAIRAVADALDAAVDELVPLADEESHLGTGRLTGELGRTTFQLRLFAEVLDDGGYLDATLDSADPDWPPGPRADLRRMLTPLGPVVVFAASNFPFAFSVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ0</accession>
    <name>A0A7K0JQZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="335" mass="34250" checksum="87EE40F9BB5FB030" modified="2021-04-07" version="1">MSDFAASVFGPAAGGDDGSEGASPRVAAGGQATSVVAFRGEEGFVPGYWIPANSVAANALGGESGTYVSPGRSMLLHWRVVTALAVLGLLFGVLFGVVRHPTYTSTQELYVGKTLNVANTAAIAGLATAATQIAQDYAQLATTAAVTNGAEKALHVHQLPGTLAATVVSSTPEIEVIATAKSASVAQRLAGAGAQALMADVSKLNLYSQASLNSLKQQYAAVEVRISNDQSEINALRSQGVPATNPRIQSLQQDVSLGNLQAQTLSSQYANQESPYPAEESVLQSLGPARGAIGDRKKAVEIGAVAGLLIGVLLGVAVASAIDLRRRRATATARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR32</accession>
    <name>A0A7K0JR32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000287">
        <property type="protein sequence ID" value="MST32406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="14185" checksum="B02ABA68E6964CB4" modified="2021-04-07" version="1">MTTVDRGEKRRARHRGGIIALIWAGMLAVLAGVMYAFQGPTMDIRGPLDLWEVLVIVFFAGLVALRPGRPPRPRKAKVTGAPSMALAFAFLLGAIGWVFGLYMAYFAIPLLAFCISRWRAEWKGGRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR34</accession>
    <name>A0A7K0JR34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000202">
        <property type="protein sequence ID" value="MST32059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="389" mass="41389" checksum="261285AEA060413A" modified="2021-04-07" version="1">MLVVSEYLPLRGGTVSQTMLHARELDRAGDSPLVLTRPVPGRPRHEEIDGVPVERVGLAGQGVVAKAAAIAATGWWLWRHRGSVSAANVMLDSDFAAIARAAGVRAVTMTWVGSGDAGRCLGGLLRPLRRRLLAGVRHVVLTPTMLAELAGFGYDATIIPVPVDPQRFQVTDAGSRLLARQQLGLDDEPVVLFVGHIKHGKGIDLLLEACRRLNDTAGPFRVLLVGEPPLRADRAYEDELRRVASSSELRGRVHFCGRSDDPRVYYRAADVFCLPSRREGMPNVLLEAMASGLPCVAPPSAGGHDLLMGGLGAVPPSGSPDDLATSIGELLASPADARSIGLAAASAVRGEYYSPRRVIAEYQRLWASPGALRCREPPASRPAGPSDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR63</accession>
    <name>A0A7K0JR63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="33124" checksum="8147A8EBF3102CD6" modified="2021-04-07" version="1">MRTVWAWHGMGSRSAEGGQPAVVACSPGGERRRLRRLATALVHDDEAAIEAAVLALSRSRRALAPVALVVGALMMLLAGLRAAFSGPRLFLVEVLPATWVWLGMLDLKLHVLRGREFRDWHGAPALVAMVLIVALTVAAYWLSTVFALALDSPDRRVPAAFSAARSHLRSAAVVGVLAGAVLAVAVVIAPRWGRVPFSVLLGAAVAVLMVSLVAFPARVVGLPARAPRRDKLLLAAVASVAGALVCSPAYALGRVGTVLLGSRHLVVLGVVLVAFGYLLEVGASCAVHTVKTSAKLLGGRSEPATRPGAGTGSWPGPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRD7</accession>
    <name>A0A7K0JRD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000311">
        <property type="protein sequence ID" value="MST32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="459" mass="49201" checksum="E8D017ED1EE06EC6" modified="2021-04-07" version="1">MSNELQEKLDELGRELDVPGVAAGVSVGGREIYAFHGVTSVDNPLPVDEATLFQFGSTGKTFTATAVLRLVDEGRVDLDAPVRTYVPELRLKDAEVAEAVTVLQLFNHTAGWDGDLFEDTGNGDDALARYVERMATIEQVTPLGATVSYNNASLSLAGRLIEKVTDKPYEVAMRELVLGPLGLDDTLFFANDVITRRFAVGHTRHDDGRITVNRPWALPRSAHPAGGMSAPAADQIAWARFHLGDGTASDGTRVLSEELLRRMQEPTADMRGSALGDYVGISWLLRDLDGERVVAHGGTTNGQHSDFLLVPARDFAVISMANCGPNGSELNHRLTTWALEHFLGLEEKDPEPRPVDGATLAAYTGRYETIAAVCTITAEGERLIARMAPKEQMAAVLGDADDDPPIPLMLVTGEGDPFVVPDGPAKGMRGYFTRRGDGAVAGVHLGGRLAERVPPAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN2</accession>
    <name>A0A7K0JRN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000252">
        <property type="protein sequence ID" value="MST32239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="5627" checksum="60C4DE8383E3CDBC" modified="2021-04-07" version="1">MNWVGVLISCASASLSRAAEVLTEAELVGHVLHRGDDRPRPPVLVTHPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN7</accession>
    <name>A0A7K0JRN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000338">
        <property type="protein sequence ID" value="MST32600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="17814" checksum="51B5C0BFFE30277C" modified="2021-04-07" version="1">MRSGPRCYWAVVDRWMIEDGMVPCPAVGQRWETGLEILLADAVEVDASARRTLRIGVDPLRPATPVYDVVGRLCPHPWQGWHLVDAGAVVFVGRDRGREFPHGATVRALSPLVVEPDHWADDLRVANPLGWRSWLVRRALGASALADPDMAGAVYVELGATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY7</accession>
    <name>A0A7K0JRY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000365">
        <property type="protein sequence ID" value="MST32700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="213"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="460" mass="48140" checksum="137AA68BC9185C07" modified="2021-04-07" version="1">MTTEAATATNGRGAVRLRALVPGTASARVESLPGTDRRVVTVRIDPAHRRGALTAQDSTTLAEAARLALSQRIPLLVIMASSGADVNEGVAALHGWGSAALALSQCSGVVPVVFVAVGLALSGPALLLGMADIVVMTPDAVAYVSGPAAVSQWTGQRLAPEALGGLAVHDRTTGVAALTAADENEAVEVVATLLDHLPDHADSLAPTVPTDDPLDRPSPELQDLIPASATGSYDVRDVVRAIADDGDFLELRSRWAPQLVTGLTHLGGMAVGVIANQPQAMAGTLDIAASQKGARFVSFCDSFNVPLLTLVDTPGFMPGKDLEWRGMIRHGAELVYAYADAQVPRVCLVLRKAFGGAYIVMDSKGMANDLCLAWPSAQIAVMGAQGAVQILHRREDADTQARLAQAYEEEHLNPYTAAARGYVDLVIDPADTRATVVRALQMLAGKRETLVSRKHGNGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS15</accession>
    <name>A0A7K0JS15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000370">
        <property type="protein sequence ID" value="MST32730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029592518" evidence="1">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="9669" checksum="8C66854EB90694A1" modified="2021-04-07" version="1">MSRRRFLRTGSVTMAAAAVVGAVPGLPSLLGEAESEAPGSSAMAGAASPALSDAAGLEGPLTAHVSDLSGEVSLFVQDRTIVVRDPALVARLLAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC3</accession>
    <name>A0A7K0JSC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S58 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000302">
        <property type="protein sequence ID" value="MST32464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="388" mass="39495" checksum="5116867EB2480569" modified="2021-04-07" version="1">MTDEGAGQGTGRVVRAADLGIRIGTGRPGPHNAITDVAGVRVGHTTLIAGDGPLVVGSGPVRTGVTVVVPGDDVGRAQYFAGCHRLNGNGELTGLEWIRESGLLTSPIALTNTHSVGVVRDALVAAEVRSRPREEAFWSLPVVGETWDGMLNDVNGFHVRAEHLFAALDGARPGPVAEGGVGGGTGMICHEFKGGIGTASRVVADAAGGWTVGVLVQANYGERARLTVDGVPVGREIPTSEVPAPEAPPGEVTLPAGSGSIIAVVATDAPLLPHQCRRLAQRAGLGVARVGGVGAHSSGDLFVAFATGNAGDVYPGGPESAEGPLTRSVTMLADPWTSHLSEAVVDATEEAILNALVAGATMAGRDGITAHALPHDRVREVLAAYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD5</accession>
    <name>A0A7K0JSD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="19843" checksum="774879FBFC9EA6D0" modified="2021-04-07" version="1">MVDRRGLDDDQLDAIAEQGWHAVQDNPPESHVNILGHLILSLVDEMKARRDSGGTFPLQLAVELDGAGDYAFAIGARAALGEHGFLPPQLVDSALRRLERRAGSWLERNATAEEVSAHEGQLRTLSAEMGLSGFETRDDGLVGVHTDEAGYRSVARFATEASRLVGAWVQVVTDDSDAGGPTKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK3</accession>
    <name>A0A7K0JSK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="273" mass="28830" checksum="C9FF742D442F5E52" modified="2021-04-07" version="1">MPVVGTGGPTPPEGSVGSGPRGPSEPLVVIPTYREATTIGRVLDLLDAALPGVHVLVVDDGSPDGTAEVVRGRAGGRSGVHLLQRSAKRGLGAAYRTGFAWGLERGYGVFVEMDADLSHDPALVPALVDGLRDADLVIGSRYLSGGEIPDWAWYRRCLSLAGNRYAAYVLRLPLTDLTSGFRAYRAGILRAIDPLTTSADGYGFQIEMAYRAVETGARVVEVPIRFAERAEGRSKMSVGIAAEAFVRVTGWGIHRAAGGAVRGWWGGGRRGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK6</accession>
    <name>A0A7K0JSK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">pdxS</name>
        <name evidence="6" type="ORF">GHK86_07435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000329">
        <property type="protein sequence ID" value="MST32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="31694" checksum="253EDD2DD05D5468" modified="2021-04-07" version="1">MSAPSEDSSSRTTGTDLVKRGLAEMLRNGVIMDVVDAEQAKVAEDAGAVAVMALERVPADIRRDGGVARMSDPALIEGIKAAVSIPVMAKARIGHFAEAQVLETLGIDYIDESEVLTPADEAHHIDKWKFTAPFVCGATNLGEALRRISEGAAMIRSKGEAGTGDIVQAVRHLRAILGDIRKITQADSAEIYGWAKELRAPVALVREVAETGHLPVPLFCAGGIATPADASLVMQLGAEAVFVGSGIFKSSDPARFARAIVEATTHFEDPTVVAKVSAGLGEAMRGQDAGSVETRLAERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN2</accession>
    <name>A0A7K0JSN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum_form domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000441">
        <property type="protein sequence ID" value="MST32951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septum_form" evidence="2">
        <location>
            <begin position="74"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="20147" checksum="DF44D99C039F74AD" modified="2021-04-07" version="1">MGSVAGRGRDGRSGAHPAAGRPPRPLTVRGLRHWGRWLALCAAASGLGGCSFAGIGTTTPFAARNVSVFRLAPGMCFNPPTKVQAQLTDLRIVPCRTPHTEQVYYTAGTYPAGKGAAYPGATKLERKADGVCVQHFAAYVGTSYQHSSLFYTYLLPTVRAWTTSGDRQLVCVLTTTGRTATRSWKGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP4</accession>
    <name>A0A7K0JSP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ORF">GHK86_09560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="260"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="497" mass="52493" checksum="3C46B3F85D67C031" modified="2021-04-07" version="1">MVCGTTSNAGKSTVTAGLCRHYARRGARVAPFKAQNMSNNSAVTRSGHEIARAQAWQATAAGAEPEVAMNPVLVKPMGDRRCQVVVMGRPLGTMTAADYHRMKPELLDVVLAALADLRRRYDVVILEGAGSPAEINLLDADIVNLRLAHDAALPAIIVGDIDLGGVFASLFGTVALLPDAYRRLVKGFVVNKFRGDPALLLDGTARLQERCGIPTLGVLPFLDGPEIDSEDSLALDRPLTAAAAGTDEGADPTRIHDVLDVAVVRLPRIANFTDIDPLRMEPGVRLRWVDDARSVGQPDLLVIPGSKATVADLAWLRSRGLHRAVDAVRGVVLGICAGYQMLGRSITDPGGVESSDPGADGLGLLDAVTTFGPDKVTRWRHGRLFGRHASGYQIHHGVVQASGPPLVELDDGTGDGAIGTTTGGGTVWGTTLHGLLESDGARKALLGQVAGKARKRIGHGGSFEAARQRRIDRLADTIGEHLDMEAVDRILAEGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ2</accession>
    <name>A0A7K0JSQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase</fullName>
            <ecNumber evidence="2">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gltD</name>
        <name evidence="2" type="ORF">GHK86_09535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000442">
        <property type="protein sequence ID" value="MST32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="17351" checksum="C0E8311BB7DF9F8E" modified="2021-04-07" version="1" fragment="single">MADPRGFLAHGREVPDRRPVPVRLRDWKEVYEPFPADRLATQASRCMDCGIPFCNDGCPLGNLIPDWNDLVYRDRWRAAIERLHATNNFPEFTGRLCPAPCEAACVLGINADPVTIKQVEVSIIDRAWDEGWVTPVPSATRTGRRVAVVGSGPAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ6</accession>
    <name>A0A7K0JSQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000447">
        <property type="protein sequence ID" value="MST32986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02793">
        <property type="entry name" value="MopB_CT_DMSOR-BSOR-TMAOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041954">
        <property type="entry name" value="CT_DMSOR/BSOR/TMAOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molydop_binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="16829" checksum="130004A32F9A2F19" modified="2021-04-07" version="1">LGGPAAARWPLHLVANNPATRLHSQLDPGTASRAAKVAGREPLRMHPIDAAARHLGEGDVVRVRNGRGACLAGLVVTDAVRPGVVQLSTGAWYDPDDPATDRPLCRHGNPNVLTADRGASLLSQACAGQHALVEVERWCGPPPPVRAWEPPSLHRPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST1</accession>
    <name>A0A7K0JST1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_09665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000445">
        <property type="protein sequence ID" value="MST32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="8"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="290" mass="30641" checksum="1CF8A1B316C4C45E" modified="2021-04-07" version="1" fragment="single">MSDAGIAVELRGARKRYGTKTALDGVDLAVEPGTFCVLLGPSGSGKTTLLRCLAGIERLTEGRLVLGDRLVADGPSHEPPERRNLAMVFQDYALWPHLTAARNVEFALGRLRLGRGEAAARVQRVLDRVGLGHLAHRYPNELSGGEQQRVALARALVGGTGLLLFDEPLSNLDADLRERMRIEIGTLTRDAGTTAVYITHDQAEAFALADVVGVLREGRLVQLGPPEEVYARPATPFVARFTGLAGELPVEVLGGAAGHGPSGQPLLPVRPAAGCGDGPERATLLATAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ9</accession>
    <name>A0A7K0JSZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000365">
        <property type="protein sequence ID" value="MST32704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="23009" checksum="27C4C1BFA88C60D8" modified="2021-04-07" version="1">MPPTARPPAIGTDADYPDYITNLQLTVLDLQLKNVIVNNAIEHYRRHRWDEIRTLQNLQEALARFPDDREGNRHAARYLWGYLYGDRLGRLRDLANWMDDQGIVDQDRLRAWAHTSHATDFVGQIKGLGPAAYAWLVMRLGVDTVKPDLWIHRFTQQAIGRDLDDTTLVDAITEAAHRVGRQARELDGAIWEMMRGEAGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT13</accession>
    <name>A0A7K0JT13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dnaX</name>
        <name evidence="3" type="ORF">GHK86_10210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000481">
        <property type="protein sequence ID" value="MST33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="40330" checksum="F5D331DAFD669E54" modified="2021-04-07" version="1" fragment="single">MADVPGAGEPYQSLYRRYRPQRFEEVRGQEHVTRALRNAVREGRVAHAYLFSGPRGTGKTSTARILAMALNCADPQDGEPDGTCPSCVAIRQGSSLDVQELDAASNRGIDEMRDLLSRVALGIPGRWKVYIVDEVHQLTAVAASALLKTLEEPPPHVVFVLATTDPQKVLQTIRSRTQHFEFRLLGSDVLAGLLRDVNDSAALGVAPEAIDLVVRRGHGSARDALSVLDQVAALGEVDDEAGTVSDIVDAMADHDPGRILVAVAEAVASGRDPRRLANDLIEHLRNGFLAEQAPSLVLLADDAAAEAARQAGSLGRAGLVRALEVLGRTAADLREAVDPRVTLEVALVQLASPATDASVEGLTRRVERLEERLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT57</accession>
    <name>A0A7K0JT57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000486">
        <property type="protein sequence ID" value="MST33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016899">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="259" mass="26352" checksum="877E7A68F22367DB" modified="2021-04-07" version="1" fragment="single">MTTGRANWAGNVRFGAAELAAPESVPELQELVAGRRRVHALGAGHSFTPIADTDGTLVSLHRLAGGVRVSEDARRAWVPAGATYARVAAGLHAQGWALHNLASVPHVTVAGACATGTHGSGPANPGLAAAVTALELVHADGTLATIRRGDDRFPAVVVGLGALGIVTAVELAVEPAYEVTQEVWLDVPLARVQARLADVLGAGDSVSLFTGWSTPDSIDQVWVKRRVAVRGDPRAGSGAGPTSGAGVAAEVGELAGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC0</accession>
    <name>A0A7K0JTC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000508">
        <property type="protein sequence ID" value="MST33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030907">
        <property type="entry name" value="Ferrit_encaps"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04535">
        <property type="entry name" value="ferrit_encaps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="15160" checksum="FDFA71B81B9753B1" modified="2021-04-07" version="1">MTPSARNRTERTTVAQSAGLHEDGELLSDETKDRHRALVSLQEELEAVDWYDQRVEAATDPELKTLLAHNRDEEKEHAAMVLEWLRRRDAVLDEQLRTYLFTEAPVTEVEDAAMGAGGSEAAGDGSLGLGSLRGVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH3</accession>
    <name>A0A7K0JTH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000524">
        <property type="protein sequence ID" value="MST33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="13762" checksum="DD2BB7EC54456A95" modified="2021-04-07" version="1">MALAGARVAVTRTGRALRDSVAERAASEDARSRALRLRASSRRHRRVFSIEGRIEEQPVLGVLRDDGLVVTASLLQRAQLLVSMGDEFEDDDGSSRPASLDGPPLSVLLTLIRACDQALAIELGPSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH9</accession>
    <name>A0A7K0JTH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ettA</name>
        <name evidence="10" type="ORF">GHK86_11015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000534">
        <property type="protein sequence ID" value="MST33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="7"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="327"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Arm" evidence="7">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="359"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="559" mass="61009" checksum="8E431F09792E3F25" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK9</accession>
    <name>A0A7K0JTK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="104"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="28242" checksum="9F6E10C183B6FEB5" modified="2021-04-07" version="1">MVEAIWRFPLKSAQGQQLARVPFGLDGPVGDRAWACVAADGRVVSAKHPRRWGRLLEVVAVVDESDFGGGRVLITVPGGSPVEAGSTGADAVLSAWLGEQVTLSRVVPEGAGLERWWPGEEGMIPEWATGHAGEVQTTEVAGAEPGGRFVDFAAVHLVTTGQLSELAAEGVDADVRRFRPNLVLDIDVAPGPGDVINVGGELRLRVSVPTPRCAVPGAAQPGLARSPEVLRAIGRRRVDIAGYGRAAVFGAYADVLRPGTANVGDPVTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN7</accession>
    <name>A0A7K0JTN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000546">
        <property type="protein sequence ID" value="MST33283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="22826" checksum="23E39323D0B091A6" modified="2021-04-07" version="1" fragment="single">MRVLVTGGAGFLGSHLVDRLLAEGHTVEVVDDLSGGSLGNLADARASGGRLSFHRLDVRGPDLAALLGRRRPELVYHLARLGAAGDGAAAAGTTLTAAMALLGAACACGAGKVVVALPAAELYAEASSRQLPVRESHPLEPRTAAGVAARAVLDALRLWRERHDLEHTALALGAVYGPRQVTGPVAGIAAAVARGEAFEVAGDGRQTDDYVYVDDAVDALARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS4</accession>
    <name>A0A7K0JTS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Sulfate adenylate transferase</fullName>
            <shortName evidence="2">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">cysD</name>
        <name evidence="4" type="ORF">GHK86_11490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000564">
        <property type="protein sequence ID" value="MST33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00064">
        <property type="entry name" value="Sulf_adenylyltr_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="3">
        <location>
            <begin position="29"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="303" mass="34955" checksum="564DE48902E20335" modified="2021-04-07" version="1">MTTTLTHLQRLEAESIQIFREAVAESERPVMLYSIGKDSSAMLHLARKAFYPSPLPFPLLHVDTTWKFRAMYEMRDRVAAAPDVELLVHRNPYCLEHGINPFDHGSATHTDLWKTEGLKQALELHRFDLAFGGARRDEEKSRAKERVFSIRSAQHRWDPKAQRPELWRLYNARVRPGESVRVFPMSNWTELDIWQYILAEDIEIVPLYFSAPRPVVERDGTLIMVDDERMAARLAPGEEPQLRSVRFRTLGCYPLSGAVESTATTLEEIIQEMLLSTTSERQGRVIDFDSSGSMEKKKQEGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS6</accession>
    <name>A0A7K0JTS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000567">
        <property type="protein sequence ID" value="MST33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="5949" checksum="4DF7046329AE2BAE" modified="2021-04-07" version="1">AVPLRRLGTGEDIAEAVAWLGSNQAAYVNGQVLYVDGGLSTALMGILPRPAGIPSGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ3</accession>
    <name>A0A7K0JTZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="10449" checksum="852B56CDAC01420B" modified="2021-04-07" version="1">MAETVVPTSEVRAALSQITKRFDAGDPEPVFFGSHRRAQAVLVPIATWERLLAHAEDELDLDVARRRLADRRPWLSEEDLDAALAAAAKKASGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU69</accession>
    <name>A0A7K0JU69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000613">
        <property type="protein sequence ID" value="MST33487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13759" checksum="D9BFA94450DD5D66" modified="2021-04-07" version="1">VGLAAAVDYLERLGMEAVRDHERALSAYALTSLRERFGDDLTIHGPLDADRRGGLISFAYKDIHPHDLSQVLDESGVCVRAGHHCAKPLMRQLGVGATARASWSVYNDEADIDALADALVAADRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU86</accession>
    <name>A0A7K0JU86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000616">
        <property type="protein sequence ID" value="MST33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="11033" checksum="1BF69A2DF0D723F9" modified="2021-04-07" version="1">MVTGGWEYARVTAVDGRWVVDREDGVPPPELEPYADLSKALFVLDEDGWLLDPAWQPEWPYVSLRRRRWPAQPPDGRDRRAAGSDPVDSPSGSPYPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC0</accession>
    <name>A0A7K0JUC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_12475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000630">
        <property type="protein sequence ID" value="MST33531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="731" mass="74879" checksum="FE30AB64CB10B0BE" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG8</accession>
    <name>A0A7K0JUG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000651">
        <property type="protein sequence ID" value="MST33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="265"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="479" mass="49460" checksum="A44953B5102CA712" modified="2021-04-07" version="1">WVGRFAAGSAAAVVLTAALAVALVPLRSHLSVATVALVLVVPVVVGVAVGGFAAGALATAVGFLTYDFVFIPPYYTLSVGTAQNWTALGVYAVVMVVVSRVVGRVETARAEAQSRARELRRLFDVSELLVRDASAAALLDGIVRAVRRAFELDGAALLLPTAGGLTLAASSGTALADDELQALSAGARPPAGSQLRVVALVISGRPAGLLALRGGRVADRAGEDLLRAFANHLALALERSQLQEQALRAGVLEEVDRLRRGLVSAVSHDLRTPLATIKVATSTLLDPAAPPPPEDAHELLELVDGQANRLDRLVTNLLDMTRIQAGALELRRSPVALAALFEDARARVGAPGEPGRVRLQADGDLPLVDVDRVLVGAVLANLLDNALSYSPADEAVTVVADRDGPGRVVVTVADRGPGLPEGAGGSGLFESIARREAGGAGGLGLAIVQAFVEAHGEQVWVEPREGGGSRVRFTLPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH6</accession>
    <name>A0A7K0JUH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3516 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000652">
        <property type="protein sequence ID" value="MST33591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="223"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="850" mass="92515" checksum="BFB8E6A2EDF5D612" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL8</accession>
    <name>A0A7K0JUL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP synthase F1 subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpC</name>
        <name evidence="9" type="ORF">GHK86_13055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000670">
        <property type="protein sequence ID" value="MST33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="11823" checksum="E039AD7D294C1D63" modified="2021-04-07" version="1" fragment="single">MATTTVEVVSPTKVLFRGEAEMVVTRSVDGEIAFLADHVPLLAALDSCVTRVIAEGGNETRIALGGGFVEVRDNQVSILAADAALADDIDVDAARAELAAAEQRQRDAAGDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR8</accession>
    <name>A0A7K0JUR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000554">
        <property type="protein sequence ID" value="MST33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="5">
        <location>
            <begin position="46"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17639" checksum="ACCE65A9EC935272" modified="2021-04-07" version="1" fragment="single">MPKPRTPKGRARETAARLAAEYPGDARELCELDFETPYQLLVATVLSAQTTDVRVNMVTPVLFARWPDPADLAAADPGEVEEVIRSTGFFRSKTRSIIGLASDLTGRFGGVVPSRMEDLVTLPGVGRKTANVVRSVAMGLPGLAVDTHVGRLVVLLGLTAETDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT1</accession>
    <name>A0A7K0JUT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000695">
        <property type="protein sequence ID" value="MST33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="49" mass="4846" checksum="4ACB22BFF3AE3CA4" modified="2021-04-07" version="1" fragment="single">MSLVDTVAAAGLVARTRPLDLPPGARPDLIAAAGADGQLWIADGYGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU7</accession>
    <name>A0A7K0JUU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000699">
        <property type="protein sequence ID" value="MST33721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="272"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="374" mass="37915" checksum="2111DE411C038C0F" modified="2021-04-07" version="1" fragment="single">MPGSVVVAGARTPIGKLSGGLASFSGAQLGGLAIEAALQRAGVAADAVDYVIMGQVLLAGAGQVPARQAAIAAGIPMTTPATVVNKVCLSGLNALYQADLMIAAGDAEIVVAGGMESMTNAPHLLPGARAGYRLGSATVVDSMMHDGLEDARSHEAMGLDTEHYLPTFPAITRERQDAFAALSHERAARATKDGVLAQEIVPVSVPQRRGDPVVIEADEGIRPGTTTESLGRLRPAFATDGTVTAGNASQISDGGCALVVMSKAAADRLGVAPLGEVVGYGMVAGPDTCLLTQPSRATSRALERAGLGVGDVDLFEFNEAFAAVALGAMDDLGLPEDVVNVNGGAVALGHPIGMSGNRLALTLLHELRRRGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV07</accession>
    <name>A0A7K0JV07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ORF">GHK86_11780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="WJHE01000579">
        <property type="protein sequence ID" value="MST33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="16143" checksum="C0CA579DCBE83081" modified="2021-04-07" version="1">MGSRSDLPVMQAAADALAELGVPHEVRIVSAHRTPLHMLDYGRSAAGRGLRVLVAGAGGAAHLPGMLAAVTTLPVVGVPVPLRHLDGLDSLLSIVQMPAGVPVATVAVGNARNAGLLAARILATADPELQDRLARLAADAEATVLGHDAEVSGGPARAGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV73</accession>
    <name>A0A7K0JV73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_14175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000751">
        <property type="protein sequence ID" value="MST33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="41"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="3">
        <location>
            <begin position="314"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="405" mass="43576" checksum="05F44F60668FF5D8" modified="2021-04-07" version="1">MLPPPARRELQGQPSSRASRAAPPGAGGLRSAGMSRETAFHPRIAALTDDWMDLFGYAAPAVVTGTSEEYRAVREAVGLMDFSMLRKVDVTGPGALALLDGMLTRDLTRLRPGHIAYGALVDDDGKMVDDCTASVLAEDHVRFCGANDRDAEMFAAAAAGTEVAVRPFTDDMPHLCVQGPRSRDLLAALTDDDLSNAAFPYYTFRDGVRIAGIPVFMTRLGYTAELGYELWVERDRALELWDVLMEEGQAWGMRLVGMTALDLLRIEGGFIIGGVEYDPSVSPFECGLGWAVDFAKERLHGRAGLERDRTATTRRLASVVLDDGGDEATAAPLHLRNGGAPIGVVTQAVHSPLLEGRTLGLAQVHRDHRSAGTAVVAVVGGREVAGEIVSHPVYDPQRTRAKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV82</accession>
    <name>A0A7K0JV82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000755">
        <property type="protein sequence ID" value="MST33870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="14728" checksum="6B507F15C25E592E" modified="2021-04-07" version="1" fragment="single">MRAIVATAAGGPEVLQLQELPAPVPGPGQLLVDLAAAGVNFMDIYGRQGRKPYAGSPPWVPGAEGSGTVAAVGEGVTAFAAGDRVAWASAPASYAEQVVVDASRAVAVPDGVGLREAAAVMLQGTTAHYLCHSTYPVAPGDVVVVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB5</accession>
    <name>A0A7K0JVB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000766">
        <property type="protein sequence ID" value="MST33907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8603" checksum="7110EC61C098C50E" modified="2021-04-07" version="1">MYDIVRFERRGIPAVAVATEPFVDEAIEQARLLAMDDCRVVYVPHPVQLLTPAELRERAVAAFPAVVAALTSGRGPDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG7</accession>
    <name>A0A7K0JVG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000777">
        <property type="protein sequence ID" value="MST33933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="215" mass="22716" checksum="769FE739AD14713F" modified="2021-04-07" version="1" fragment="single">MPDTSTPLPGGGWMALPGRGRAWAWDSGPAPHPGGATVVLLHGWTSTAALNWHRCFRPLARRHRVVAMDHRGHGRGIRSPKPFTLEDCADDVAALVDLLGTGPVVVAGYSMGGPIAQLLWRRHPEVVRGLVLCATSTRFGDVRLPGRATQAVGVGLSLALAAVPTPVLEQVRRRLGLAPDTTGMAAWAVAESGYGDPISYVQAGAAVAAFDARRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH0</accession>
    <name>A0A7K0JVH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000785">
        <property type="protein sequence ID" value="MST33950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9699" checksum="A43E53546378EDB9" modified="2021-04-07" version="1">MWRRDDTRAAPLRAHDEALEGLPPALVITAELDPLRDEGEAYGRRLQSVGVETTVLRFDGMIHGGVPGPVENRWRAQVPGDDVTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI1</accession>
    <name>A0A7K0JVI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000790">
        <property type="protein sequence ID" value="MST33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="28463" checksum="B790583D57962E4D" modified="2021-04-07" version="1">MSNEAERRRWNDAYWSSIWPRREAFTARVTPILVDRLSPPDGAQVLEVGCGGGTASFALAERVGAGRVVGVDLSASLVSLAEERAAARGAGNVSFVVGDAQEDPLPPGPFDVVASQFGVMFFDEPSRAFSRLRGHTRPGGRLGFACWRDPASNPWNVGPALAPFLPTPPGPAAGKSATGPFSLADAAATGALLAAAGWGGVEVEAHDLVVTVEREALFEVGELDFRGVPADRRDEALAAVEERLDPLVRPDGRLDAPLAFWTVTAVAPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW09</accession>
    <name>A0A7K0JW09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein GHK86_15580</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000866">
        <property type="protein sequence ID" value="MST34137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="11420" checksum="22E382F7E18CF305" modified="2021-04-07" version="1">MLVTTMNDVPGYRVTRVYGEVMGLTVRSRNIGSQFGAGLKALAGGELKGMTKNLYESRREVVDRMLAEARALGANAVVAMRFDTSELGQTWTEICAYGTAASIEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW76</accession>
    <name>A0A7K0JW76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000897">
        <property type="protein sequence ID" value="MST34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10999" checksum="107C90F14FBBFD83" modified="2021-04-07" version="1" fragment="single">MTSSAMTSTEADAQYDPPLHVGWFSRKGLLLHLTMLFVVAGCTAATWWQLDRALAGNGLSWAYTFEWPCFAVFAIVLWWKILHDPVEDDGSEPAPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW84</accession>
    <name>A0A7K0JW84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3159 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000901">
        <property type="protein sequence ID" value="MST34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="24794" checksum="36C928B52EB37F0C" modified="2021-04-07" version="1">MAHTDHSLLPHFEIPRLRDLAGHAIPHLLEATLIPIGIFYLSRLQWGDRVAILAALAWSWAALVVRLVQRRPIPGMLLIGIAGFTARSMIGLATGSLFVYFLQPSLATASVGALFLFSVPFGRPLAERLARDFVPFPPGYLKRPVIRRFFAQISVVWALVMLANACGSVLLLVSEPVTTYLAAKTGVSAGATAAGVAVSFWWFKRTIHRHNLRAARQGAAAPDAVVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB2</accession>
    <name>A0A7K0JWB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AA_permease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_16140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000912">
        <property type="protein sequence ID" value="MST34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="61"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="17662" checksum="2F8BFFF5E82D3A46" modified="2021-04-07" version="1" fragment="single">MFGPKQSPRGKPSMTTAASERGPSTTPPAEGRLGAGKLRLPDVIAQSVGFMGPVFSSAFVIPLIIGIGSATGQGGGLASPLSVIIAAVGIFGLGWVISQYAKRIHAAGSLYDYVTEGLGQRVGAVAGWLYYGGVMVLGAGLALLIGGFIHDTIQSEFGAGTMPDWAWTLLIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF9</accession>
    <name>A0A7K0JWF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair protein RadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">radA</name>
        <name evidence="4" type="ORF">GHK86_16350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000929">
        <property type="protein sequence ID" value="MST34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="3">
        <location>
            <begin position="63"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="285" mass="29723" checksum="348DE7C4CBEB22E1" modified="2021-04-07" version="1" fragment="single">MARPRTVHRCSECGGSTPRWAGRCPSCGSWGTLVEERVERSTPAGSGEPASAPVPLADIELGSAEPVPTGVDELDRVLGGGLVPGSVSLLGGEPGIGKSTLLLQALGSLAGRGARCLLVSAEESGPQVRRRAERLGVARPGVWLVAETALSGIRSAVEQVRPDVVVVDSIQTVWDPELESAPGSVAQVRGCAHELALMARAGGWAAVLVGHVTKEGALAGPRVLEHLVDTVLTFEGDRHHALRLLRTVKHRFGPTGELGLFEMTDAGMQGMPDASGVFLGDRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN8</accession>
    <name>A0A7K0JWN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000963">
        <property type="protein sequence ID" value="MST34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="423"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="513" mass="53650" checksum="4D7BD9CEEB0B61CB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP0</accession>
    <name>A0A7K0JWP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUFU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000965">
        <property type="protein sequence ID" value="MST34361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037181">
        <property type="entry name" value="SUFU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103359">
        <property type="entry name" value="SSF103359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="2">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="12258" checksum="2C92476592CDB819" modified="2021-04-07" version="1" fragment="single">MEAAVRAADGAEPYARHHPRAPHRFQGHGPVEEVLVTRVAGHWHLVTLGLSELAVKESPDRDVSGWGFELSFRVVADEEPLWAVELLANLAGYVWTSRHPFAPGHHLDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX59</accession>
    <name>A0A7K0JX59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001060">
        <property type="protein sequence ID" value="MST34538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="383" mass="40808" checksum="046EF3642338797A" modified="2021-04-07" version="1">MEQRYPSIRVGGGPRQRGRVYGEAARDRVRISREAYEEAFGRTAGWTWAQARDAAAAYVAPVEAAFPQYLEEMRGIAEGAGLPFEDVLTLNTRTEVMYAAKARQAASLGRGECTSFALLGERTASGRLLAGQNWDWLAHCTETVVVLEVEQPGAVNFVTVVEAGLLAKASLNAAGLAVATNALVTSADRGAPGLPYHVILRALADCETPADGVDVVLGHVRSSSANYLLASADGLVLDLEAAPGDYRAVSVLEPEGGALVHTNHFLRPPAGQDDVSVWAMSDTHLRRQRALPALADPGRRHDPESIRGVLADHAGYPFGVCSHADPRVADGPAWATITAVVMDPAERRLWLTSGRPCEAPLLEVELGGLLHEPTPLAKHRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX76</accession>
    <name>A0A7K0JX76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="7106" checksum="A9DD8B6459D3DF29" modified="2021-04-07" version="1">MSDRPSLGGYTLQGSERPSKAYAKDRVCREPGCQTRLSIYNNGKYCFQHEPMAVPRTRGKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB0</accession>
    <name>A0A7K0JXB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001047">
        <property type="protein sequence ID" value="MST34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="12892" checksum="ED097EF743FFFCBB" modified="2021-04-07" version="1">MRLLVDESLSTTVAALLRDGGHDAVHLTDLGLLGAPDPVVMAAAGDASRVLVSADTDFGELLAVGRHPGPSVVLLRRAPKRPELQARLLLTALGQVEAELTAGAVAVISPGWVRVRRLPVEPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF5</accession>
    <name>A0A7K0JXF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="20754" checksum="5F69EC6D05C6F433" modified="2021-04-07" version="1">MDTREIRDAASLRALAHPVRLALVETLALHGPQTATQAGEHIGESPTTCSWHLRQLARYGFVEETGTGKGRARPWRLTASSMDIAGGGDADSELAATALIGLVRERAFERHRQWQDARGRSPERWREAAGESQLLLWVTVEELEEVQAMLLAVQERFAGRLQDPASRPVGALPVEVLVLSHLVGPPEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR3</accession>
    <name>A0A7K0JXR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001192">
        <property type="protein sequence ID" value="MST34748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="34413" checksum="7DA4C3C6983CBB7D" modified="2021-04-07" version="1" fragment="single">APEPSRLLLEAEVAMYAAKSSGRGWEFYAPEHDHHSRERLTLVAELRRAIDGDELEVHYQPKVDLRSGAVFGMEALVRWRHPERGLLGPDVFVPVAEEAGLIRSLTLRVLDAAAQEHRALTDLGFGHLEVAVNLSLRSMVELDFPDQVAKVLRRHGVPPTALTLEITESSVLSDPARTVGMLVRLAELGTTISVDDFGTGYASLSHLKRLPAGELKIDRSFVAGMLDAPRDAAIVASTIDLARKLGLRAVAEGVEDGDTWAALAELGCDQVQGYFVSRPLPPPQLEAWLVAKRSGPSTPHPRPPAGVRPAALRGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY23</accession>
    <name>A0A7K0JY23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur carrier protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS</name>
        <name evidence="1" type="ORF">GHK86_17040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000997">
        <property type="protein sequence ID" value="MST34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="6871" checksum="7ED096061A5FD6DA" modified="2021-04-07" version="1">MELVVNGEHRRLGDGATVDALVETLALGRRGVAVAVNSEIVPRSAWTVTHLTAGDVVEVLHAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB3</accession>
    <name>A0A7K0JYB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001324">
        <property type="protein sequence ID" value="MST34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="30093" checksum="21E45F1F7EA1AD08" modified="2021-04-07" version="1">MAVPAGRVRREQLRLLVRSKSFVVGAAILLLWVVCAVFGGVFRPYNPTAQNLLAINQAPSAAHPFGTDNLGRDVLSRVILGSRDILIVAPSAALLGTILGTILGLVQGYFRGWVDSVTGRVVDAFLALPVVIVAFLIIVAAGPSVPTLVVVIGFTFALVISRTVRTAVLQERELDYIAAARLRGEGAAHTMFVEMLPNVLGPIIVEFTVRLGYAIFTVATLSFLGFGIQPPTPDWGADIYATYNYVSAGYWWETLFPALAIASLITAINLIGDSVESVIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK6</accession>
    <name>A0A7K0JYK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2236 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001373">
        <property type="protein sequence ID" value="MST35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21257" checksum="55A580EDEB930B2A" modified="2021-04-07" version="1" fragment="single">MRQAVAADAATADPGWFGPGSTAWKVQADASMYVAGIAAFALQLLHPLALAGVADHGSFAEDFFGRIMRTGLFLQGVTFGGRAEAAARVAQVQRVHTSVVGTAPDGRPYAAGDPELLRWVHLGEYLAIAAAYRRFGAYPLGPAELDRYVDEVAVVGEAMGVPDPPRSWAALDAAVQAYRPSLAVGEQTRAALRFLAQPPGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN0</accession>
    <name>A0A7K0JYN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001395">
        <property type="protein sequence ID" value="MST35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="12293" checksum="85E3AC9D6E4393F9" modified="2021-04-07" version="1" fragment="single">MSVVVVGLNHRSAPLDVLEATAVPAEALPKALGDLAGRAHLDEVLLVSTCMRTEIYATTERFHGALGDVRDFLALWSGRPPEDFADGLYDFHDRAAAGHLLRVAGGLDSAVLGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS3</accession>
    <name>A0A7K0JYS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_20550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01001438">
        <property type="protein sequence ID" value="MST35108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="66"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="16449" checksum="B6D2BBA3FC2506CB" modified="2021-04-07" version="1">MSCAVVDTPIGPLRLTGDGEAVTGLHFGAGEEDRPGDLAAAVAQLEAYFAGRLTVFDLPLRLGGTPFQQRVWAQLQRIPYGETWTYRQLAAATGNPKATRAVGMANNRNPVSIIVPCHRVIGAAGSLTGYGGGLERKSWLLGHERGVRAERLGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW5</accession>
    <name>A0A7K0JYW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001465">
        <property type="protein sequence ID" value="MST35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="12347" checksum="5BEDDDA254150098" modified="2021-04-07" version="1">PLLEAVRASGHPVVWACDPMHGNTFTGAGGRKTRHFEHVVAEISGFFAACRSVGVWPGGVHIELTGDNVTECLGGSEAIAEDDLELRYTTTCDPRLNGRQSLDLAFRVADLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ4</accession>
    <name>A0A7K0JYZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001488">
        <property type="protein sequence ID" value="MST35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7204" checksum="146E5BFD717CDA50" modified="2021-04-07" version="1">MTLTIDCAECEMQDTPACGDCVVSFICGREPDDALVIDAAEERAVRLLGRAGLVPRLRHQQRVDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ15</accession>
    <name>A0A7K0JZ15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001215">
        <property type="protein sequence ID" value="MST34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="145"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="519" mass="56697" checksum="6ED2B5BF99942957" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ66</accession>
    <name>A0A7K0JZ66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001261">
        <property type="protein sequence ID" value="MST34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="32771" checksum="25A89B931EF43AAE" modified="2021-04-07" version="1">MTDVLVTGGAGFIGANLCRALRAADGIGRVVAFDDLSSGRRDNLDGVDTPLVEASILDPAAIGAACEGIDAVVHLAARPSVPRSIADPMASHAANATGTLTVLEAARAAGVGHVIVASSSSVYGANPTLPKSEDLVPRPLSPYAVSKLATESYALAYQSCFGLGALAFRFFNVFGPLQAPGHAYAAVIPQFVAAALDGRPLPVHGDGGQTRDFTYVDSLTAVITEAVRRRVTSPTPVNLAFGSRRSLLEVVAELEKVLGRPLEVEHGPARTGDVRDSQADQRRLRELFPGVQPVDFADGLAATVGWMQHLESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ71</accession>
    <name>A0A7K0JZ71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_21325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001559">
        <property type="protein sequence ID" value="MST35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="107"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="15656" checksum="6DA9B463DF9F2BB9" modified="2021-04-07" version="1">APGGEEPCVFCRILASGEPDEVTHVLWRHPGGGAVALLNAYPYTSGHLMVMPSRHVRRLDGLSPDESAALWEGIGLAVRAIEAAYRPEGLNLGANLGRAAGAGIPDHLHFHALPRWVGDTNFTTAVAGLRVLPEALGDTAARLRAAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC2</accession>
    <name>A0A7K0JZC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMP-30/gluconolactonase/LRE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001621">
        <property type="protein sequence ID" value="MST35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17003" checksum="0AE884627FBFAA7E" modified="2021-04-07" version="1" fragment="single">TADGFARLAGDGAVEGVLDVHAGDPGIRFNDAACDPRGRALAGTMRYDEQPGDAVLYRLDPDPSRGWRAAPLRVDQGLCNGIGWSPDGSTLYFVDSLAHRIDACEYDPATGAVGHARVLADVSPDDGLPDGLCVDTEGGVWVAVHGGGQVRRYTPTGDLDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZJ7</accession>
    <name>A0A7K0JZJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF2309 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001611">
        <property type="protein sequence ID" value="MST35313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018752">
        <property type="entry name" value="DabA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38344">
        <property type="entry name" value="PTHR38344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10070">
        <property type="entry name" value="MpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13573" checksum="E6FD5F8F88FB3AE3" modified="2021-04-07" version="1" fragment="single">DWAQVQPEWGLAGCTAMVVGPRRLTAGVDLRRRVFLHSYEPERDPDGSALEAILTGPLVVAHWIAAAYYHSTVDPDVLGAGDKVAHNVVAGVGVWQGAGGDLRLGLPRQSVFDRHRAHHDPLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZM4</accession>
    <name>A0A7K0JZM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2277 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001368">
        <property type="protein sequence ID" value="MST35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="60" mass="6207" checksum="162DA08BB7FC581C" modified="2021-04-07" version="1" fragment="single">MCRNITTLRGLEPPATPAEIDAAARQYVRKVSGVQAPSAATADAVERAVRSVAEATAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZP0</accession>
    <name>A0A7K0JZP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ruvA</name>
        <name evidence="11" type="ORF">GHK86_20255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001385">
        <property type="protein sequence ID" value="MST35049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RuvA_N" evidence="9">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RuvA_C" evidence="10">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST35049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="24423" checksum="CCC07A12DF484867" modified="2021-04-07" version="1">MPPERRPATAGGVGGFGGFGGFGGFRGGQERAVIGSLRGVLAERTRRGDHALELLVEVGGVGYRVVAPTRTLATGPEPGEAIFLHIHTHVREDALTLYGFPTRDERDCFEQLIGARGVGPSGAVTMLSVHSPAGLRRAVATDDADALVLVPGVGPKSAARLLPELKARLDLDATVELEAVDGAGGAAGSARQDLRAALAGLGYGADEIRQVVAGLPEEGRVEDLLRLALRDLAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZV3</accession>
    <name>A0A7K0JZV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">purQ</name>
        <name evidence="2" type="ORF">GHK86_20505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001427">
        <property type="protein sequence ID" value="MST35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="24027" checksum="7B073382DBA62B63" modified="2021-04-07" version="1">MTARVGVVLFPGTNCEHDVLAAVDRLGGDARLVWHGDAHLGDVDAVVLPGGFAHGDYLRPGAIARFSPVMGAVEAFARDGGPVVGICNGFQVLTEAHLLPGALQKNRGLTFLCQTVELEVVTDRSALTRGVAPGTRLRIPINHFEGNYTCDPATLADLVDGDRVVLRYTDNPNGSVGDIAGVSNEAGNVVGLMPHPERASDPLLGSDDGLVLLRALLASAGARLPAATSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMI3</accession>
    <name>A0A7K0JMI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000014">
        <property type="protein sequence ID" value="MST31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="260" mass="28005" checksum="A21D1A31922E4545" modified="2021-04-07" version="1">MREFGVLVNTSTRGGRGRSAHYGDEAVAAVVAVEAAKTDPEYAGKLHHAVLIAWVRGAPVGTLGLQWAFKETYTGDETAAERRVSGKRVGEHRKSPRARLPRPLEAGVSAAQLGRSSYAYGSRGEGKAEVIGHAVAGLAPRVQLASARSDSTAFLNTGDPLLGFAKRVDSGKTFILTPAGEELWESLRLPTTKRNARTASREELDRAILSVRSMLAFADFAATDLTVAKLVPDQVALLRAKLGEQWWRLPAFNPPPKPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMI6</accession>
    <name>A0A7K0JMI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000010">
        <property type="protein sequence ID" value="MST31158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="5248" checksum="11C1CB813F8BBAC7" modified="2021-04-07" version="1">MIWQSARLISIGAGAVVADAFGITLVYYLTGALPLIAGTVGLLMARIPTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMR1</accession>
    <name>A0A7K0JMR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000005">
        <property type="protein sequence ID" value="MST31141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="9584" checksum="8B9B3CAA0BA5C420" modified="2021-04-07" version="1">MQRDIRVPEPGAATPGEAFRRRHRSAQRSCLTYQMKASSNDGRVTSTRSTRAVDIDSATADPGSAPEGSDTRMLVPRRLVPGQRAASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV6</accession>
    <name>A0A7K0JMV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000034">
        <property type="protein sequence ID" value="MST31302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="3">
        <location>
            <begin position="145"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="37210" checksum="8D160334931C547B" modified="2021-04-07" version="1">MRAVTVVPLEKDSVDLTDLPEPPEADGPVLVATRAVGVCGTDLEIIEGQYGWAPPGEDRLAIGHESLGEVLEAPDGSGFAKGDRVVAIVRRPDPEPCAACAAGQWDMCRNGKYTEWGIKEHHGYARERYRITPEFLVKVDPGLGDLGVLLEPTTVVAKAWDHIERIGARAVWQPHKVLVTGAGPIGLLAALLGRQRGLEVHVLDQVTDGLKPDLVAALGATYHHGSVRDAAVDADVVIECTGVGQLVFDVMETTATDGIVCLTGVSSGGRSLPVDAGMLNREMVLGNDVVFGSVNANRRHYEAGADALAKADHDWLARLVTRKVPLSSWKDAYARQPGDVKTVLSFADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN08</accession>
    <name>A0A7K0JN08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000042">
        <property type="protein sequence ID" value="MST31350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="292" mass="30989" checksum="9110EA523102E5A6" modified="2021-04-07" version="1">MVESWRRAVAVTRFELDEVAEAEELFRTWLVADPRWGYGWVAWAVCHLSPAVRTGTTDLVEAERLLREGYSTPGVRDRDAVAEWLKILCHRTGRHAEARSFGRTAEELRRRAGASPLETGAVGVTEHVELEDGEGLVLRHGTTLTFGGEGLPLDQLPAVLDAMRSPERRPASRAAPKVGRNATCPCGSGKKFKRCCGPGPLPQPRPGPPGGGGGLTAAPSRIPSRARRTPGLPPAGAVTAVDGVPLPTPRAWGSGCEGLAPRLGSELPGAGAFGPWASGERVRPWSPDAPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN09</accession>
    <name>A0A7K0JN09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000041">
        <property type="protein sequence ID" value="MST31346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="8023" checksum="89EDF51414FCD6DF" modified="2021-04-07" version="1" fragment="single">MDLAAVADELYGVDPSAFTTTRDARAREARAAGDRELAEAIKALRRPSLAAWALDLLARERREEVDRLLDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNA2</accession>
    <name>A0A7K0JNA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-carboxy-cis,cis-muconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="2">
        <location>
            <begin position="429"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="531" mass="56074" checksum="DAC257419F05BBF6" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV9</accession>
    <name>A0A7K0JNV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9366" checksum="3C9EF024B0FBFE9F" modified="2021-04-07" version="1">MPERESFDVDVDGERFAVRPRPDGGVDYDWLSGPNAGYGFSSGPGIAWGSPPAGEAPELSMDRHRERIRAFLALVDPQTGYIEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ3</accession>
    <name>A0A7K0JNZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="29680" checksum="375E4B44A26BF89C" modified="2021-04-07" version="1">MSEPTGRTWVEALPKQLAPQRRLLEVLLAFCEQDPAVAWLVIGCSLARGNADALSDLDLALGVDDADADDESIAERVRRALLLLGEPVDSLTHSLPGGPQRIFVQYVDRSQIDLVLGSATAAFPADTVVLYDPHAAVTITGPAPGVAPSTLREWAFLACAALADVGKYLRRRSAWEAHARLGTARDELWKLFAVALGARDPQFGLTSIVDFAPELLPAAMQATVTEVDLDALTAAARAAAALLAQIADQLPPTLAAGFPAEMLAYVTAELGALTPTPGPGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP30</accession>
    <name>A0A7K0JP30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="415" mass="45023" checksum="69B2EDDD1B2BEC5F" modified="2021-04-07" version="1">MRVLEDVELTLHEGEIVALLGRSGSGKSTLLRTLAGLIAPTSGDVRYRGRPLTGANPGVAMVFQTFALLPWLTVLDNVELGLRAQGVGPDQRRRRALEAIDLIGLDGFESAYPKELSGGMRQRVGFARALVVRPDALFMDEPFSALDVLTAENLRGELLRLWDSGEFPTKAVLIVTHNIEEAVQLADRILVLSSNPGRIKAELTVDLARPRDRDAPAYGRLVDHIYGILTGRDETATVAPAAGRDTSTPLTQPLPDASVGGLAGLLEIVAAGGGRADLPQLADKLSFEVDDLVPLLDAAVMLRFAHVHDADIELTDEGRSFVAGDIDTSKHLFADHARRHAPLVRTITQSLGSTDDGTLRDAFFLDLLRRGFTPDEARHQLDVAIDWGRYAELFDYDTDSGQLHLEQPEAVEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP55</accession>
    <name>A0A7K0JP55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000125">
        <property type="protein sequence ID" value="MST31725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="21921" checksum="9DB58C517DA54E27" modified="2021-04-07" version="1">MAVRVVIAEDEAIVRLDLKEILEEEGYEVVGETGRGDEAVELVRRERPDLAILDIKMPGADGLTAAREITGDRLAAVLILTAFSQRDLIEQARNAGALAYLVKPFQKSELLPAIDIALGRFKEMTALEEQVRNLEERLEVRKVVERAKGILMDDCGMAEHQAFTWIQQSAMNERVRMDVVARRVVDEGLRPETPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP61</accession>
    <name>A0A7K0JP61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000040">
        <property type="protein sequence ID" value="MST31344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="13252" checksum="D418D809816664ED" modified="2021-04-07" version="1">HRRPDVALERAGRAAPDWSGGTRLGEALRAFNAEHGRRGVARGAVVVILSDGWDRGDPALVAREMERLRRLAHRVVWVNPRSARPGFAPLAGGMAAALPHVDVLLSGHSLAAFEEVLAAIRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD8</accession>
    <name>A0A7K0JPD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrile hydratase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018822">
        <property type="term" value="F:nitrile hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042262">
        <property type="entry name" value="CN_hydtase_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024690">
        <property type="entry name" value="CN_hydtase_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02211">
        <property type="entry name" value="NHase_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="SSF50090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHase_beta" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NHase_beta" evidence="1">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="20942" checksum="F075F2F29A88E2ED" modified="2021-04-07" version="1">MDGVHDLGGMHGFGPVPVDDDGPGFHEPWEARVWALSGPVMQRTTIDRFRYSIERMAPAAYLTSSYFGRWLQAIETLATDPELLARSPVTRPAPNLPPRSCRFATGERVRVRNAVTPEHTRVPRYLRRQTGTVRRVACIWPDPTRSAATGVYGEPVVHYTVAFAAADLFGPDTDHVVTADLTETDLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD9</accession>
    <name>A0A7K0JPD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000138">
        <property type="protein sequence ID" value="MST31793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="591" mass="62588" checksum="F33557B3D199E028" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ3</accession>
    <name>A0A7K0JPJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_04015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000167">
        <property type="protein sequence ID" value="MST31892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029555756" evidence="6">
        <location>
            <begin position="26"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="200"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="395" mass="39186" checksum="56915E10F06FE8E9" modified="2021-04-07" version="1">MRRPALVAAGLVFAAFNLRASVAAIAPVLPEVQRADHLSSTGGGLLNAAPVACFGLFALATPTLLRRFGADRLLWLVVAGVAAGTGLRSVAGVFPLFLGTLVVGAAIGVGNVVLPGLVKRDFPERVALLTGLYAMALSGGAGLAAGLTVPLEHAGGFSWRGGLAIWAIPAVAALVLWPPGRVHREGGARPRGAWALLRRSPVAWAVTAFMGLQSLGFYALFAFIPTLLEGAGSSATLAGVELSVSAVASLLAAFATPTVAGRLGRAWPPVAVAVGLNAVALAGLAVDPHGVGAVTVWMIVLGAGQGAMLSLALGFIVLRAPDPAQAANLSTMAQGIGYLVAAAGPFAVGALHQLTGGWSVPLAALGAALAVALAAGVVASGDRLVPAAPQGAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN9</accession>
    <name>A0A7K0JPN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="332" mass="34283" checksum="12A18ABA9FA47FE0" modified="2021-04-07" version="1">MSDGTDDAPDELIDEPVSWGGPGTSHGDDSGGDAPQPDAGATSDEEPDPDVEASAVPPSGRGTRPAFVAARAVVVLAAAAALYTVVVPATHVQRSRLATLVPTASGLRQFAKVPAHGTVQNAARTGLTDVTAAAKKTPDRTGVYSVSWAASQTSVGGVIAFLLPDAAGTKGAATEFEAHQLGTTSYAANGLHRQHAGAVAGIPGSHVATFVPSAKAPKGTPSLALTEQRYGRVVAVTEAIGTATDVGTEASALATREYALLQRQHGQVDLAVTEYPLGGTIGWAVGAVVLSAAFALLPVSWRRRRERRRRAYEEEMANRIVVKGQVIVKHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ2</accession>
    <name>A0A7K0JPQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000092">
        <property type="protein sequence ID" value="MST31539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="318" mass="33778" checksum="1484B13D88F05295" modified="2021-04-07" version="1">MRSERRLGGALSLPPKVVMGGSAGAGRWGAGPTDLRWIVMMELPLVLEPDRDDPDCAAVCVDGSAEGRRRRFLVDTGAAVTQVPRAWLAHGSTSQGERTGEAALGSAHQHLAQLDSLRVGSLEMRKATVGVLAEEHPHPWGLLGMDVLGREAWQFDFAERRIGMGSVGSDADRPWLSLDRYPAGQPLVEMSIGPVPATAVWDSGAGITLVDAGFQHRHAELFVPAGSATGRDSGGNQAQTPLAVMAASRIADVDFPPCKVAVVDLGHATAALDRPMDLILGYTLIRSAVWTFDFPRQRWVVAPAGLDSSAAGGVKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW9</accession>
    <name>A0A7K0JPW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000194">
        <property type="protein sequence ID" value="MST32002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="267"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="477" mass="51853" checksum="4891A6F195ACC19F" modified="2021-04-07" version="1" fragment="single">RRYLQGRFELGTAGRFIALIGDAELDEGNVWEAIADPALQGLGNVLWVVDLNRQSLDRVIPELKVRRLEALFAASGWHVAEAKWGRRIEARFAAEGGEALRRRLDEMSNEEYQSIVAAPRGEVRTRLLAGADPAVKAAVGEVEDAELWDLVTDLGGHDHAVLADTWAACDAEADRPSVVFAYTMKGWGLPIAGEPLNHSALLTPAQIDELRARNGLTTETEWDRFDPASGPGRWCRIVGERLNNRPVPARPRLPVPPAVGGRPAAKVSTQEAFGRLLTSLARHEELARRVVTLSPDVSVSTNLGGWINKVGVFRAEEATDWFGESQLLRWRQTPAGQHIELGISEMNLFGMLAQLGLAHEHHGEVLLPIGTVYDPFVCRGLDSLVYGAYNASRFVVVGTPSGATLAPEGGAHQSGITASIGIELPGVTFAEPAYARALDWLLCDGLDRLTAPDGDSLYLRLTTRPIEQAPFEAALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY8</accession>
    <name>A0A7K0JPY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="9180" checksum="39CAF21BB6E0EF47" modified="2021-04-07" version="1">MVDGGGGTVVGTGDVGGEVGGTDDEGGGGAVVDAGAVVGLVELGLAGARRHTTTEPARVRIPYTWPTVESETTDAAARLTGDVARRAAPYART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ15</accession>
    <name>A0A7K0JQ15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="477" mass="51924" checksum="5B97E85D193EDF4E" modified="2021-04-07" version="1">MHTLHRYLSLLHHPNAADLIVLAGIVAVVASVLFLLGWSRPTTIFSIGIALEAFSGNWRDIPLPLPLDRVAFLVALLVLFARGTAAASDRRIVFRPIHFLLLAIAVYVLLNGLNAGTIEHSYGFYSWLDRLGAIPFLMFTLGPIIFGNQRQRHVLLVAMVVLGAYLGFTALAEGAKVTALVFPRYIENQALGITQGRARGPFLASDAMGLALFDCAALAIVAAVTWTSRRARWVAWAVAAVDLVGIFFTLTRSIWLGAIVALLVTMGAQPRLRRRLPHVAAAGVVVVFVFLVAVPGLITHVDHRLTYANSVYDRYNTYTAAIRAMEAHPIFGIGWQTFETVGQQYFRQSGTYPLTGLGLEVHDVFLSHLAEIGIPAACLWLLALLTSVGRAVLQRGPRELEPWRYALLAMFIVFVSVATFSPLSYALPNLMIWMMAGIVARDRLSVPRAPAGVFVVANRSPGGLVLFPGGTALEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM6</accession>
    <name>A0A7K0JQM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000250">
        <property type="protein sequence ID" value="MST32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31959" checksum="8DBBF57E2796DDE5" modified="2021-04-07" version="1">MATEPGPVAGPLAVLLDALDLETIDRNLFRGKTPPTRLQRIFGGQVAAQALVAAHRTVPDKTVHSLHAYFLRAGDPAAPVVYEVDPIRDGRSYATRRVVGLQDGRAIFNLQASFKLPEPGYDRQVPFPEDAADPASLPNWTGFGFDDPEKDEEALPPPSSPFELRMAPPAGGYARLLWFRTLGALPEDPTLHACVAAYASDLTLLSVPLETFAREAAAAGRSMEPPAFVASLDHAMWFHRPFRVDRWMLYAQSSPTSGDGRGLCLGHMFGADGTLGITVVQEGAIRPPRPGDAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY9</accession>
    <name>A0A7K0JQY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_04670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000197">
        <property type="protein sequence ID" value="MST32019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="119"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="26057" checksum="C5C7DEB41D3DEA1C" modified="2021-04-07" version="1" fragment="single">MSVDEQLTGLPTPDRDGRRRLRDRLNDLLVPPAGEDGRPPAAPHTAVSVLDRPEAPPGWRTDLAASGLGPRVAVAVLVLGVLTRFLPAGPLWFDEAQSVGIARLPVMQLFAALRQDGSPPLYYLLLHGWMLLVGRSAFAVRALSGLTSVATIPVFERLARRVLPERARWPAILLLASSPFAIRFADEARMYSLVVLVVALGSLALLRALERTSTPRLVLVSLASGALALTHYWGLFLLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR58</accession>
    <name>A0A7K0JR58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="231" mass="23986" checksum="208ED035B5175CEC" modified="2021-04-07" version="1">MLNMVAEQEVPNVAKPGVSSRLMTQGGRSVATRRALVDAAVETLKSEGFSGASARAIAGRAGCNQALVFYHFGSVVDLLLAALDEVSATRFERYRQVVADAVTPAELVGAAAAIFREDLDAGHVTVLAEMIAGASSTPGLAAALTERIAPWKAFAAEILSRVAGPALSAVVPADEAAHGVVALYLGLEMLAHLDGDRRTALALFERARGLSPLLSLAYARSASPPLGEEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA6</accession>
    <name>A0A7K0JRA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000301">
        <property type="protein sequence ID" value="MST32461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="2">
        <location>
            <begin position="287"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="491" mass="52553" checksum="5B8D79D3A96B72DD" modified="2021-04-07" version="1" fragment="single">LLQLAAAGAEPGVLDGDALALPEGEDLSPGQALAELAAAREDVRQAEEGLAVWTAGEWRPWAERWRAVAAGRALYRTLFDLRVRIEREGDLFELVWGFGRLRWQLGGERVDQPLLCTPVEVTMDTRSGRLEVAPAGPTVLDVSWSVDLPVRDRATLNRLREQLEDEEVDPWTPEAAGLLRPVLRAFDHDGVLVPPGQARPPVGEHAALDPGEWVLYVRRRQPNFRGFLDEQRRLYEAGAAVPDPFAALAVDETSPSSSDDPYAAGAGDSPGGPGPAGEEEPLLPLAVNEEQLQIVAMARSRAGVTAQGPPGTGKSHTIANLISHYVAHGKRVLVTAAKEQALGVLIDKVPEGIRQLCVPVLGSDAAARARLQATVTTIADAAHRRPDRSEIARLEADLAGLRARYAATTNTLKAKRAAETAIPPVPAPDADTEIAWTPSGAAAWVRRHPGLGWVPDRIGPDTPPPVTTEELAELVRHCAALEAADAEAAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB3</accession>
    <name>A0A7K0JRB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000310">
        <property type="protein sequence ID" value="MST32488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="8086" checksum="4ECC44F2B760A784" modified="2021-04-07" version="1" fragment="single">MATERWVLLGLAPARAAWFGEVTRWSTSGALPAEFVKCLSAEEARARLGSGRPWSALVVDAAAPGFDRDLVDAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM0</accession>
    <name>A0A7K0JRM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_07570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000335">
        <property type="protein sequence ID" value="MST32580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="431"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="646" mass="70450" checksum="8C87957C8D5F7028" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP2</accession>
    <name>A0A7K0JRP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_07760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000344">
        <property type="protein sequence ID" value="MST32616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="571" mass="59381" checksum="8EB906B550CCC383" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS1</accession>
    <name>A0A7K0JRS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="118"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="548" mass="59365" checksum="E45D035598B5FC92" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS49</accession>
    <name>A0A7K0JS49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000386">
        <property type="protein sequence ID" value="MST32776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="31102" checksum="4761BD33B1A1A237" modified="2021-04-07" version="1">MSAMEILNHTSAMAVDTSLAGQLDNSYIQLQNLELQATTGKQINQPSDNPAGTATALQLNAEISQLSSYSAAATAGTGQLNAADSVLSSINTTLQQVQSDVMQGANASSQDKTTLSALAANVTALKQTLLTDANSNYNGVPLFSGTVNTSPYANASANPPDYTYTGGSVAPTVAVGPGQRVPVGVTGQAVFGSGTGSVFALLDQISSDLTSGNTAALSGTDLTQLKQAMSTASSAQATIGTATDELQTAQTQNTAKSTALQTSVSNVVDANEAVVASQLSLQETQYQAALSIVAKVIQPTLAEYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC6</accession>
    <name>A0A7K0JSC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_08825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000400">
        <property type="protein sequence ID" value="MST32823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="119"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="26475" checksum="C54C4CA5F4B5B590" modified="2021-04-07" version="1">MSEAVRVRLFLAAAVGLAVVLAVGLGGLTAFGQRVAAYGEHFARVAVYQRHTTDIVSAITFDYRGIDTLFEEFMLFAAVTGISVLLRPLADERRNAPEDQAPDRHIPPPSPTVGLLGVILCTVLVVFGVETITHGQVSPGGGFQGGVIAASAIFVLYLATDYRTIDRYKPGPLLEAADGAGAWGYAAVGLAGLATGGAFLLNVIPLGTPGMLWSGGTVFVINLTAGLEVAGAFVLLVSEFLDQMEVVRGSNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF4</accession>
    <name>A0A7K0JSF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ORF">GHK86_09120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000417">
        <property type="protein sequence ID" value="MST32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5029989923" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029989922" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="136"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="34873" checksum="5DAB17AFD067C95B" modified="2021-04-07" version="1">RGVVVVAGNANVATGPQGGRDAVELGGLAAGLTGLHPSEVLVASTGVIGRPYPMAVLRAWFAHAGGVRDGSGASGDGAAGSGAPGVTARRTGRAGDVAAAIMTTDTVAKTAARRVGPATVVGMAKGVGMIEPDMATMLAFVCTDAAVEPPDLDRLWRRVVDETFNCLSVDGDTSTSDTAVVLASGAAGPVPEADLTVALREVCLDLTLQLARDGEGATKLLTVTVRSARDRDQARRVAKAIVNSPLVKTAAHGGDPNWGRVAMAIGKNADDHDIDPDRVVIRFGDLEAYPAVPGEEGLAALADLLAGDHVDIDVELGAGDAEATAYGCDLSAEYVRINADYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI7</accession>
    <name>A0A7K0JSI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="8865" checksum="46A3AF91EE4E046C" modified="2021-04-07" version="1">MSTTIRVSEETRSRFAELAKATGRPMTELLDEAVDALERRVFFDRLTTRYAELRRDADAWGAIEAERAAESGSLADRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ8</accession>
    <name>A0A7K0JSJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MarP family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000428">
        <property type="protein sequence ID" value="MST32910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="397" mass="39411" checksum="3387401BF459E43C" modified="2021-04-07" version="1">MNWLDAVLLVVLALAALHGWRDGGARQILFLAGLWLGLWVGAELALPLGGLSAGAGRAAVAVAVVVAAALVMATLAGLVGRRVAYVLHHLRVGVIDAVAGLVVSVVGTVFALWLVGNIAASSRVPAVDRAVSDSWLLRTVDGVLPPLPAVFARVESFLAAEGFPVVFVDLPPEPSPAVPLPSSTAVAAGAARAAPSTVQVVGPACGAIVEGSGFVIDPGVVVTNAHVVAGDPHPRVVTAAGSRPATPVGFDPQLDVAVLRVPGLDAPALPVSTGAVPAGRAGVVLGYPNGGSLRAVGASVTATYPAVGLDIYDRALVTREIHELHATILPGDSGGPLVSLGPSGAGSPPAGSVIGLVFARSTDRPAVGYALTMGPVRAAVDRAEQATAPVSTGSCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSK2</accession>
    <name>A0A7K0JSK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000327">
        <property type="protein sequence ID" value="MST32549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15425" checksum="BB04754EABBEE8C8" modified="2021-04-07" version="1">MSEARSDQASTELATLRQRLVEAEEEYRRTRAEDYVVRLVRDATIVDAHRGGLSSREISSLVGDIGQPNVVRTRRRAITRRDVVPEGLLDPADAVRASGMGPAAFISAVREGRIRPMELAGGVKAFRTEDVEALAASASHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP9</accession>
    <name>A0A7K0JSP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage tail sheath family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_09515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000441">
        <property type="protein sequence ID" value="MST32953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="265"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="3">
        <location>
            <begin position="414"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="526" mass="56580" checksum="DD8FA64F1E1C31AE" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS5</accession>
    <name>A0A7K0JSS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000450">
        <property type="protein sequence ID" value="MST33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="55" mass="6465" checksum="AD3C5292252C4296" modified="2021-04-07" version="1">MLTTTLVSLVLLAWAVLFLLHDARRRSRRMPLLKRVEHLGGNLAEEAEAWLRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT08</accession>
    <name>A0A7K0JT08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000474">
        <property type="protein sequence ID" value="MST33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="163"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="373" mass="41200" checksum="A2557449BADCDCA7" modified="2021-04-07" version="1">MDDAYVEHERAAAWLRVLLDAQGRSVGTARAYAGRLSLYLSWAAAAGVEPSAPQADQLARFARWLERTPSRKHRPGRQRRRAADPKVVALGPARSAAMVEGILAAVVEFVRFGASRGWCEPAVAERLSFRTELAFAPRSWDRGERSERPVVERRVVRRRRVQTPPETLSAQQVGALVDACSNSRDRFVVEMLYATGLRVAEVCGLRLADLHLVPSAAHLGCRVEGAHLHVVRREDNDNGALAKSAWPRVVAVTKELVACHDAYRFERDGVPPAAESDYLLVNLWRAPVGRTLTVDAVERLFVRLSARTGFRARPHMLRHSFASEVAMATKDPALVKELLGHASVSSTDVYLHARWADMRAAVDGQARSSGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT15</accession>
    <name>A0A7K0JT15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000481">
        <property type="protein sequence ID" value="MST33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="23408" checksum="391C8ED77D87D605" modified="2021-04-07" version="1">MRSTVSAWQHAAVDPWSHYRTLRRIAMDQRNAGASRGPLPVSDPWGEYAADQLAVLDHLGVDRFVVVGCCIGGSFILKLCSLAPERVVAAVLEQPIGVTADNRSLFEAMRRDWATELLDARPELAPGEMEAFLAAMWADDFVVSVPREEVARCPVPLLVLPGIDDYHPTAVGREIAELAPHAELLEPWKDSPEHVAAATEAVERWLLDRVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT18</accession>
    <name>A0A7K0JT18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000356">
        <property type="protein sequence ID" value="MST32669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="14542" checksum="0BE324DEFA1C1783" modified="2021-04-07" version="1" fragment="single">MIEVRSLDLTSPVSYAVVVVLALIDGVIPLVPARTAVIGLGVLAGSGRAAAYPLLAVATAAAFVSDNVSYWLGARYWPRIQPMLFRGARARRAWGWVEGQLRLHGAALVVLARVLPGGPTPITLSAGSVGLRRRTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT54</accession>
    <name>A0A7K0JT54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ORF">GHK86_10355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000491">
        <property type="protein sequence ID" value="MST33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="126" mass="14431" checksum="55A3C2D7B2530505" modified="2021-04-07" version="1">MARIAGVDIPREKRLEISLTYIYGIGRTASTRVCEGTGIDPSTRVRDLTDEEVIRLRNWIDANLKVEGDLRRDVSQDIKRKMEIGSYQGIRHRRGLPVRGQRTHTNARTRKGPKKTVAGKKKVRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT76</accession>
    <name>A0A7K0JT76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="195" mass="20468" checksum="E113A6C5C247DD0E" modified="2021-04-07" version="1">MRVRSLGFATDLAVLRAGGSTIVEEGDHLVVRTPSSPNYWWGNFVLVAASVPVAAGVEVFHREFPDADHVAIGVDGTDGAVPASAVGLGLEADVSVVLTAPAAVSAGGVDADVRPLSSDGDWEQLLQLRQQDDHPAVQLRRQEDPAADDAFQRSRVDGARRVVDSGAGVYLGAFRDGYLVSTLGVVCAGSRTVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC1</accession>
    <name>A0A7K0JTC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000514">
        <property type="protein sequence ID" value="MST33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="303" mass="30784" checksum="407E5B85DCE62690" modified="2021-04-07" version="1">MSGGSGVGAGGPGGFGGPGGPGGGRGGPGGPGGGRHPADLALEVLRGDHETTDAVVTSLSVDEAILLDQVGYEPVGLLTGASVVQVAAFAGLGVGFSANGELGQLSEALEVARVRALGRLTDEARRHGADGVVGVALDLGDLRHGGRLVHLVATGTGVRRDGRGRRGRQGSGRQSAPFTAALNGQEVHLLERAGYEPLGIVTGVCAYHVGRQAFGSWASSVRTNQEMTIYTEALYDARELAMTRLQDMALGLGADGVVGARIVERSGVWGAHVLEFSAIGTAVRSDGEHRSLDPKLVMDLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF2</accession>
    <name>A0A7K0JTF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000525">
        <property type="protein sequence ID" value="MST33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="347" mass="39972" checksum="A67F234E9C6D4A37" modified="2021-04-07" version="1">MYTHNGVEYFIVDAHIALWDAREDNQRNIHGKQFIDCFYDYHRNLSPQSEVWTYEEYLYQGSERLMKDLFTDGYVDHAIFQPAYLGEFYHRGFGQTEEAFALATAHPDKLTYNHNFDPRNGEAGLERLRADAERFGLKGVKLYTAEWHGDSRGWKLDDPWAYRYLEACQELGITNIHVHKGPTIRPLDRDAFDVADIDHVATDFPDLVFIVEHIGLPRLEDFCWIATQEPNVYGGLAVAVPFIHTRPRYFAQMIGELIYWIGEDRILFASDYALWTPRWLVERFADFQIPEDMTEYGPLTTTQKKKILGLNAAKLYGLEVPPRLQVPDAGESATGPRQPDSADLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF4</accession>
    <name>A0A7K0JTF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_10820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000524">
        <property type="protein sequence ID" value="MST33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="499"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="412"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="618" mass="68941" checksum="CA99CAF20B6A6F66" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI7</accession>
    <name>A0A7K0JTI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_11075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Rhodanese" evidence="13">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="35887" checksum="DFE09CFED600AAF7" modified="2021-04-07" version="1">MSPAPGWRGLIEEYRDRLPVTDATPVVTLLEGATPLIAAPRLSERVGAEVRLKVEGANPTGSFKDRGMTLAISKALEAGAEAVVCGSTGNTSASAAAYAARAGLTCAVLIPDGYIALGKLAQALIHGARVLQIRGNFDAALDIVRELGETAPVTVVNSINPYRIEGQKTGAFEIVDVLGDAPELHCMPVGNAGNITAYWKGYREEQDAGRITKLPRMLGFQAAGAAPIVLGHPVEQPETVATAIRIGRPASWYGATAAATESGGAIAAVTDEEILAAYRFLAEEESVFCEPASAAAVAGLLKVGAPAGARVVCVLTGHGLKDPDIAIGQIAVPAVVDADPGAVRRALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK2</accession>
    <name>A0A7K0JTK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding protein 2</fullName>
            <ecNumber evidence="6">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mrdA</name>
        <name evidence="6" type="ORF">GHK86_09370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000433">
        <property type="protein sequence ID" value="MST32924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="99"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="323"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="686" mass="72754" checksum="CD6B879486916D56" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV1</accession>
    <name>A0A7K0JTV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="57"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="618" mass="67753" checksum="7C3258F5003A964E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX5</accession>
    <name>A0A7K0JTX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="12892" checksum="9DF6C385A458E354" modified="2021-04-07" version="1">MSTEIAATPVGPAPEPAGQRTRWRAEVLDGVPLAEVVAGAGGIAGWLWTEWGGSAADERGFEAFAAVALGYRRELWLWIVGDRTWEQCSIGLLGRLGRRRRCVLGDGQGVGQQAPDHPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU01</accession>
    <name>A0A7K0JU01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000589">
        <property type="protein sequence ID" value="MST33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="197" mass="20028" checksum="26A9A1F65D338C21" modified="2021-04-07" version="1">DQARHVLTAAAGAGLGLRVHGNQLGPGPGAALAAELGAASVDHCTHLSDADVEALAAAGTVATLLPGAEFSTRSPYPDARRLYDAGVRVALASDCNPGTSFTTSMPLMVALAVREMHLTLDEALEAATAGGADALRRDDIGRLTPGRRADLVVLDAPTAAWLGYRPGVDLVATVVRAGALVAGRWPAKAREAGPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU05</accession>
    <name>A0A7K0JU05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGDG_synth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000587">
        <property type="protein sequence ID" value="MST33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="4">
        <location>
            <begin position="70"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="24227" checksum="2C47DD9933332F55" modified="2021-04-07" version="1" fragment="single">MVQLTTPAEELGGGGRLAGRATRARVLLVTAAMGSGHVQVSREVAQRLGAAGHETRVEDLNDLMVGPSGQWLAHLYPWMVQRAPWLYDGIYRIFFKAPQDRGERVDVPALAAMPGLRRVVREFRPHVVVSTYHIASQALGRLRAEGSIPVPVITFVTTFGVHELWLHPATDGYLCISPVVAGALGQRTSAPVRCCGPVVRPAFDRSRRDREVPRRRAGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU46</accession>
    <name>A0A7K0JU46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000467">
        <property type="protein sequence ID" value="MST33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029661344" evidence="4">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="27543" checksum="B1785A5829F79EDF" modified="2021-04-07" version="1">MRASASAVALPMPVPPPDTRATQPAFASGARTERCVDGSVGRTAHVPPSARPGGPEMPKIVDRELRRAEVVEATWRLMARVGIDRVSIRDIAAEAGCSTGVIGHYFRDKDEILLTALRLVGRRERERIAERTAGRRGLAALEAVVGAVLPVGDEQTLEMAVWVSFWGRAFGDPVLADEQRRYYAEWLALLRRHLDDARRSGDLAAGLRPADEARRLAAVIDGLAIQAVFGPEDLGPGRLLALACAHLDALRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU72</accession>
    <name>A0A7K0JU72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3039 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000613">
        <property type="protein sequence ID" value="MST33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="70" mass="7466" checksum="6BBA4EE8B6B58532" modified="2021-04-07" version="1">MSHIVLEGVKVSDEEFVSAGPSVVEGIVNGTPVKALCGKVWIPGRDPKRYPICPTCKEIAEGMGWKIPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD3</accession>
    <name>A0A7K0JUD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000636">
        <property type="protein sequence ID" value="MST33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="91"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="23464" checksum="BA6E6F60F6375BCE" modified="2021-04-07" version="1">MNRDELLKQLYDDTLVGNGPRVLELTNQGLAMDVGPEELLYEALIPSLEEVGARFERGDFFVPEMLVAGKAMAGALEILRPLLAETGAETVGTFVMGTVKGDVHDIGKNLVNIMLEGAGFHVIDLGVQVAPEKFIAAIEEHKPDIVGFSAFLTTTMPMFKANINALEKAGLRDEVIVMVGGAPVTQEYADAVGADGYAADASAAVAKAKDLLARRRAAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG1</accession>
    <name>A0A7K0JUG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recG</name>
        <name evidence="9" type="ORF">GHK86_12585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="WJHE01000635">
        <property type="protein sequence ID" value="MST33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="269"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="480"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="697" mass="76191" checksum="246BB3419A8AC216" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ6</accession>
    <name>A0A7K0JUQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000691">
        <property type="protein sequence ID" value="MST33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="15838" checksum="E01D16CFF5E0BE50" modified="2021-04-07" version="1" fragment="single">MSEPARAAVLMALADGRALAATTLAAEAKVAPSTASGHLGRLVEGGLVTVESSGRHRYFRLAAPEVAAALEALARLAPHQQVRSLSQGTHAEAIRRARTCYDHLAGRLGVALLDALVATGALHVQEAGEGSDPVLGAGRARTYLLTDDGRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV9</accession>
    <name>A0A7K0JUV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000707">
        <property type="protein sequence ID" value="MST33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="53"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="230" mass="24541" checksum="B610ADED67808F37" modified="2021-04-07" version="1">MYHAVAREAHDPNQLCVSPERFAAQMTWLARRGLRGVSVVSLLRAVQRGDAGGLVGITFDDGYRSVLHAALPVLRRHGFGATAFVLSDPPAPENTWDEGTAWPLLAADEIRELAAEGVEIGSHGATHTRLTGLPHRRLAAEVADSRAALGEVAGGEVQGFAYPWGAMDAAARAAVAAAGYTYACAVSTPYRGLSTLALPRAYVGDRDGGFELALKRRLHKVNSIWKGRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV04</accession>
    <name>A0A7K0JV04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_13800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000724">
        <property type="protein sequence ID" value="MST33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="25707" checksum="9346369ADF748549" modified="2021-04-07" version="1" fragment="single">MSTLLTPPTAEPAASPEAPPPAAPPHRRRWTRAILPAYSWLVIAYLVFPIAIMIVYSFNQSAGGLPQVSFAWNGATLRWYRQWNQVPGLTSAFWLSIRLAIASAVFATVIGTLLALALVRYRRPQFRGKALVEQTLFVNIAAPEIVLGASLLGLFVSMNLARGFFTLLVSHVMFSIAYVAITVRARLAGFDPSLEEAAGDLGAHPLTTFRKVTLPLILPGVMAGALMAFALSIDDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV22</accession>
    <name>A0A7K0JV22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000735">
        <property type="protein sequence ID" value="MST33815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="20310" checksum="A3C551FF5CD1ECDA" modified="2021-04-07" version="1">MTVLVAYATCHGSTRGIAERIGARLAQSGVDVDVRPMAGVADAGAYEGAVLGSAVHGGRWLPDAMTFGRAHQPALAGHPVWLFSVSTLGDEESMLGARTAHRLRAWRKESAELAELRRQLRARDHRNFAGAVTRADWPPTGRVVFRVLGGRYGDHRNWPAIDAWADRIAREWAANPGSPEPHEPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV26</accession>
    <name>A0A7K0JV26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF1211 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_13575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000706">
        <property type="protein sequence ID" value="MST33742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="195" mass="21352" checksum="FED2BE9053706848" modified="2021-04-07" version="1">MSTGRLEAFSDAVIAILITVMVLELKIPHGATLQALRPLLPIGLTYVLSFVYLGIYWNNHHHMFQVTEHVNGAILWANLHLLFWLSLVPVATGWMGDNGFGRLPTLAYGLVLLLSAIAYFVLQTAIIADQGTESKLRAAVGGDWKGKASPVLYLAAVGLAYVDRWVSLALYVAVALLWMVPDRRLERALASSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV57</accession>
    <name>A0A7K0JV57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000738">
        <property type="protein sequence ID" value="MST33823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="214" mass="23254" checksum="6EA122F27B5CF905" modified="2021-04-07" version="1" fragment="single">MSTDRADATRAWLDARGAGELPHTGRTLAIHLHNVWAMLRRWGQPERVCLAGLAHSVYSTDAFPDAVVGFEARPELRDLIGEEAEELVFLYCTLPRPALLDALEGTDPGEAVATVDRRDGSPRLLPRRALGDLAVINTANLAEQGQHDELVAGHWVASASRWARLAGRCAQHVPPVFAGGTVTVRPDDEQRLLDRYRAAFAAPAGEARSLLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV66</accession>
    <name>A0A7K0JV66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000578">
        <property type="protein sequence ID" value="MST33389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="10990" checksum="7323866E2673E4BE" modified="2021-04-07" version="1" fragment="single">MRAALVGLGAVGMRAARHLLADPELESLLIVARDPRAVQRAEGFDDRVVLRPARHPRIPEGTDVVVVARPDDAAGVAAGAVRAGAHVVAAVDDPHQVRLLLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV98</accession>
    <name>A0A7K0JV98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000612">
        <property type="protein sequence ID" value="MST33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="581" mass="60986" checksum="812BB1B84BAB907B" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD2</accession>
    <name>A0A7K0JVD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoenolpyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000748">
        <property type="protein sequence ID" value="MST33852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-utilizers" evidence="4">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="5">
        <location>
            <begin position="120"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="43407" checksum="6779EB13F99A8E73" modified="2021-04-07" version="1" fragment="single">AAPGVVSGPVRVLTSPDQGDRLVAGEILVAPMTNPDWVPTIRRAAAIVTDSGGMTCHAAIVSRELGVPCIVGTRRATSVLRPGEVVTVDGSRGTVTEGRRPSAPVVTAAPTATPVAPAETSTLLYVNLAMMEHAEEVAAQPVDGVGLLRAEFLVTEALGGVHPRKLLAEGRDRDFADAMVESLLTITRPFGRRPVVYRAMDFRSNEFRGLSGGEAFEPAEDNPMIGYRGCYRYVREPDLFRLELEVLARVREETPNLHLMIPFVRTRWELEACLELVDASPLGRQRGLHRWVMAEVPSVAYRIPEYAALGIDGVSIGSNDLTQLVLGVDRDSEVCAELFDESDAAVLDAIRRIVDASRQADITCSLCGQAPSNRPEFAEELVRFGITSVSVNPDAVEATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY0</accession>
    <name>A0A7K0JVY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000851">
        <property type="protein sequence ID" value="MST34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="19810" checksum="5EAF5AFEBB4BE2DD" modified="2021-04-07" version="1">DVEAVNPVNAGLMARGTPRFVPSTPASCFWLLDDYFRHTGRDPGTGLHGRAVVIVGRSHNVGRPAIWLALDRGAIAINCDEHASAAGRLAEFTRQADVLIVAAGVPGLVTGDMVADGVIAIDVGINAVPDGSTGGVHLVGDLDFDSVATRAEALTPVPGGVGPVTDVWLVRNAVLGAVLQQTNLAIGPWPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY3</accession>
    <name>A0A7K0JVY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_13425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000697">
        <property type="protein sequence ID" value="MST33714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="434" mass="45273" checksum="47F1020374AFC20B" modified="2021-04-07" version="1">MGSTDESEVAGRALGLRANWWQFSLFTAVTLLVGMTVGVERVALPPLAEHAFGVVSILYTVSFVSAFGVVKAVMNLVAGRLSDRYGRKLLLVVGWAFALPYAVLIIFAQAWWWVVVANLFLGVNQGLAWSMSVTAKIDLVGPAGRGLAVGVDESAGYVGTGLGGLAAGLLVAADGLRPAPYLLVVAIVAVGGLVTVGLIRDTLPWARAEASHHTVAPAAAVPSLGWLARYMSWQDRSMLAVCQAGMVNKVADSLVIGFFPLYLLHHGLSVAGVGVLVGVYAWVWGLGQVPTGWLADRVGRKWPITVGTFLIAGGILVIGVTRPLGPWFAGATVMGLGMALAYPNLITAVGDTAHPAWRGGALGVYRLWRDGGYALGPLVLGAVAALAGIEAALWATVGLLGLSGVALLVLLQETDPRRRTAAPPWQQHPASLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW77</accession>
    <name>A0A7K0JW77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_13865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000731">
        <property type="protein sequence ID" value="MST33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="21180" checksum="0F2CB2BA39F38825" modified="2021-04-07" version="1">MDEGSSDRAGNPQAEPPDPARELDACVVAALAGDEVAAAEVFRAVQPALLFYLRSQLPTAAVEDAAAEVWLAVARGSAASVRSSDQLRALLFTIARRRAIDLRRARRRRPVSLGEEAAEPTGSDPADGSVDAWDADDAVRRLMQLLTPDQAEVVLLRVVAGLSAGAVAEITGRTAGSVRVIQHRAVRRLAAEVQSKVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA1</accession>
    <name>A0A7K0JWA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000907">
        <property type="protein sequence ID" value="MST34235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="6">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="430" mass="47262" checksum="FFCB4D9067AB3438" modified="2021-04-07" version="1" fragment="single">MPLDPNRWTLKTNEAVQAAIDAARTANHAEATPDHLLAAMLGQQGTATLPTLEKLGVTPLTLRNRTTEALAKQPRSYGGQEAGIGRSLRDVLERADTERAGLGDEYLSVEHLLLALADRVGVGRDDLLTALRAVRGSHRVTTQDPEAQYQALEKYGRDLTQLAREQKIDPVIGRDEEIRRVIQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLRNKRLVALDLSSMVAGAKYRGEFEERLKAVLKEITDSEGEVITFVDELHTIVGAGAAEGAMDAGNMIKPMLARGELRLIGATTLDEYRKYVEKDPALERRFQQVYVGEPSVSDTIAILRGLKERYEVHHGVRIQDAALVGAAVLSDRYITGRFLPDKAIDLVDEAASRLRIEIDSKPTEIDVVDRRVAQLEIERLALEKETDAASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG3</accession>
    <name>A0A7K0JWG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000901">
        <property type="protein sequence ID" value="MST34222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="477"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="669" mass="76351" checksum="7D4097F1A7D31337" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL5</accession>
    <name>A0A7K0JWL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000951">
        <property type="protein sequence ID" value="MST34341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="15256" checksum="D56DAF1A255FAC27" modified="2021-04-07" version="1" fragment="single">MVALALAIGAVIGISLGALGGGGSILTVPALVYVLGQTPHAATTGSLLIVGITSLAGAVAHFRAGRVRIGAGGAFGLLGVAGSYVGSRLSAGVRPDLLLAGFAVLMLVAAAAMVRRRGRDERPAPQASSAAPAVIEEEFARGLPARGAIALVEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP4</accession>
    <name>A0A7K0JWP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000968">
        <property type="protein sequence ID" value="MST34365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="379" mass="40741" checksum="FB83E9B06A7C628E" modified="2021-04-07" version="1">MKALVYNNPYEVSVEEVDDPRIEAPTDAIVRITSTNICGSDLHMYEGRTSVEQGKVLGHENMGIVEDVGPGVWRVQRGDRVSVPFNIACGTCVNCEHGLTAFCLTTNPTPGMDGAAYGYANMGPYAGGQAEYLRVPFADFNLLRLPPGDDHELDFTMLSDIFPTGYHGTELADVRPGHTVAVFGAGPVGLLAAYSAVLRGAARVFVVDQHKDRLALGERFGAEPIDFSAGDPVEQILDANGGMVDRGVEAVGYQAHDHTGEEHPELVLDNLVRAVRSTGVIGVVGVYMPQDPGAADDGAKDGRVAWDYGTFFAKGQRMGTGQCPVKHYNRDLRDLIVAGRAEPGLLVSHELPLTAAPDGYAHFDRREDGWTKVVLHPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT4</accession>
    <name>A0A7K0JWT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_17000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000992">
        <property type="protein sequence ID" value="MST34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="30260" checksum="24AB213F38268BAC" modified="2021-04-07" version="1">MLSTLLSAVAFGVVLASIIAIAAMGFTIQFGLTNVLNLSYGGVMTIGGYAAYLAVAHGISAWYGLVLGAAAGAVATLAIGHGLLRRFAARGTKVFEMMMVTLGLGLVIDYTLQAISRNNISQFTVLQSAPLHLGPVTLTPTQVIITAIGLAIFIGLEALLRLTRIGKALRAMASDPSLARACGIKTSRIVVFTWLLSGALCGLAGVVYIINAQSIGYTTGELFLPLVIAAAILGGAGSPSGAVLAALLMGIVTQVFSAYGNASYSTAAGFGILVIVLLTRPSAVLSKGENEELALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU7</accession>
    <name>A0A7K0JWU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000997">
        <property type="protein sequence ID" value="MST34418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="18796" checksum="A1B5B65385E6BE43" modified="2021-04-07" version="1">GVVLEDGTEVAASAVVLAAGTGVPHLDGLPDEVRLPVRPVKGEILRLQGDPSEGGLAMTVRATVQGQPVYLVPRVDGEVIVGATVQEAGYDTTVRAGAVLELLRAAVDLVPALGEAPLAEVAAGLRPATPDNAPLIGPTGVEGLHVVAGHYRNGVLLAPISAELVVSALGSGRLPEQAAAFSAGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW2</accession>
    <name>A0A7K0JWW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RelA/SpoT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_15080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000821">
        <property type="protein sequence ID" value="MST34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="61"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="396"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="654"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="731" mass="81525" checksum="1B4D18B60A3D974A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW9</accession>
    <name>A0A7K0JWW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching protein GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ORF">GHK86_17205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001014">
        <property type="protein sequence ID" value="MST34451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="156"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="693" mass="76057" checksum="D897759428E01BFA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ4</accession>
    <name>A0A7K0JWZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001016">
        <property type="protein sequence ID" value="MST34456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="30305" checksum="3D5BC15BE0AA946F" modified="2021-04-07" version="1">MAAPTAAETRPRAAIEARTLRTDHWRRAPAISAIVLTAFVVYASWAAFYGKNFFYKWYISPFYSPCIATDCAARDAGNVGVAAHWALVPSWWSLSPAIIVLIVPLGFRLTCYYYRRTYYRAFWQSPPGCAVAEPHKRYTGETRFPLILQNAHRYFLYLGILLNGILTYDAALGFGADTGGHVGLGSFVLLINAVLLWLYSLSCHSCRHIVGGRLKHFSKHPIRFRMWGFVSKLNARHNQFAWASLVWVALTDLYVRLAAAGWLGHGGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ5</accession>
    <name>A0A7K0JWZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000842">
        <property type="protein sequence ID" value="MST34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="6880" checksum="0B78DD6E69E19837" modified="2021-04-07" version="1">LTTRVPLADLLPGDLVFFGTPGNVYHVGLYIGGGDMIDAPETGQDVSISSIYWPNLLGAGRVTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX58</accession>
    <name>A0A7K0JX58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_17260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001019">
        <property type="protein sequence ID" value="MST34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="12">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="40777" checksum="419AC1328EB071B7" modified="2021-04-07" version="1">MRLYDTARRAVVPFEAGPVVTMYTCGITPYDAAHLGHAATYITYDVLQRRLRDRGHETRCVRNVTDVDDDILRKARELGVHYLDLAAEETARFDDNMAALGLLASWSEPRATSAIPDILGFIGMVLDSGHAYQAGGAVYFDVSSFERFGQVSHYDRDTMLALAAERGGNPDDPHKRDPLDFVLWQPSAPDEPAWESLWGPGRPGWHIECSALAMRELGQTIDLHGGGSDLIFPHHECEAAQSEAATGSPFVRHWMHQGMVRLAGTKMSKSLGNLVFVHDLRKEWDPTAIRLAVLAHRYRDSWEWHDGLMPAAAARLEAWRRAGEGDAALEECRSALDDDLDTPAALAAIDRAAERGDGVSQAAALLGVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX62</accession>
    <name>A0A7K0JX62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000868">
        <property type="protein sequence ID" value="MST34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="417" mass="43974" checksum="A0EE05C698798F47" modified="2021-04-07" version="1">MRTDVPPLLHAYARPAADRSSYVDIVAGDGAEVVDAAGRRYVDALGSLWYCNVGHGRAEIADAVAEQMRTLEVFHTFDRFTNPAADAVAERLAGLAPMPDTRVFLTSGGSESVETAVKLARIAQHWAGHPERTVVVSRRPSYHGVTYAALTATGLAANQQGFGPLLPDVVQVPYDDLDALDHLGPEYEGRIAAVIAEPVVGAGGVYPPPEGYFAGLRERCDRWGAFLIVDEVICGFGRLGQWWGAQHFGVRPDLVTFAKGVTSGYLPLGGVLVGAAVREALEADEAAVFRHGYTYGGHPTVAAAALANLDLLEKEDLIARAPAIGERLGAGLGSLVDGTDVVGHRGTQGIWAIELAEGLSANAVRDALLGHGVIARPIGTSALAYCPPLVVTDEQMDRCVEGTRRAIADVRAGRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX91</accession>
    <name>A0A7K0JX91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001075">
        <property type="protein sequence ID" value="MST34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="10873" checksum="C0E1E5E0C0E8BF93" modified="2021-04-07" version="1">MVTTFHDDIRARLRPVEADETPALPYAELVSSLDTTVDAVDLLYRCALVEGGGESVHLLTEASQGLHRAAFALRELAASASVHREPAGWGDASRVPAHQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB4</accession>
    <name>A0A7K0JXB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000888">
        <property type="protein sequence ID" value="MST34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="501" mass="52622" checksum="13BC79C32F6BA31D" modified="2021-04-07" version="1">MADLLSGGPVVSAMLAAASDAVVVCDAAGAIVACNPAVEAVLGYRPEELLGHSVDVLVPEEARPVHPLHRADFGAHPVPRPMGEGLRIRARRRDGTAVPVAVSLVSMATPGGDVVGAFIRDITERTRAEDRLESIVEVHRAVLVGGPLSESLDLAARHALRIVGGDDAWVMGSVGGRVEVLAATGGSTTGYEGASLRTTDTVAGRVIDGGGALLVDDLAGSDLANERSVQLDLGPALFVPLGDPDRSRLFGSLVVTRRRGRPAFNRVDLRTAELFAGAIAVALALGEGRFAAEDLHEMRERDRIARELHDTTIQCLFATGMGLQAAVGFAEPEGQRRILDAVDQIDSAIRQLRSTIFNLQTPLGARPGIRHAIREVATEIVGRQGAELRFAFEGAVETALDAKQADELLPLVREAVANAVRHGHASRIDVLVDTIDGFRISIADDGVGMSGEPSAGHGMDNMARRAAALGGRLHVRHRHPTGTVVECHLPHGAAAGAGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG9</accession>
    <name>A0A7K0JXG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001081">
        <property type="protein sequence ID" value="MST34582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17947" checksum="869108F40C9BA245" modified="2021-04-07" version="1">SDPIAEARRQWVDHGMAPTAEAMAAVTSVFRAQQIYLTRIDRALKPFGLTFARYEVLMLLTFSRRGTLPLGILGSRLQVHPTSVTNAVDRLEAQGLIRRIPHPTDRRTTLAELLEAGRQRAAEATEAVNTVFAEPGLAPEDVQTLFDVLARLRGDAGDFQPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH6</accession>
    <name>A0A7K0JXH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_18255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001130">
        <property type="protein sequence ID" value="MST34658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="486" mass="51157" checksum="7CC42B56B868A21F" modified="2021-04-07" version="1">VSLGRVGDMFGRVRMYNLGFAIYTLFSILLSVTWLSGPAGALWLIIMRIFQGVGGAFLFANSSAIITDAFPDNQRGLALGINGVAAIGGSFIGLIVGGVLAPIEWRLVFLVSVPFGLFGTVWAYVKLVDNGVRKPARIDWWGNLTFAVGLISLLTGIVYGIQPYGGSAMGWTNPGVLAAIVGGVLTLVVFLRIERSVADPMFRIPLFRIRAFSAGNIANLLGALGRGGLQFMLIIWLQGIWLPQHGYSFVETPLWAGIYMVPLTVGFLVAGPVSGVLTDRFGARPFATGGMIGVAVTFALLEVLPVDFGYPWFALLLLAMGLSMGLFSSPNRAGVMNSLPPDQRGAGAGMMTTFQNAAQVLSIGVFFTVITIGLAATLPTTLTSGLIAHGVPAPIAHKVGSEPPIGALFAAFLGLNPIKEVIPAAVLGHLPAAQRATLTGRAFFPHLITGPFGTGLHYAFDFAIACSLIAAVASWLRATAAARPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH7</accession>
    <name>A0A7K0JXH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyl phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001135">
        <property type="protein sequence ID" value="MST34665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="9114" checksum="A54FCE5E2CE4A259" modified="2021-04-07" version="1">PPATAATRPRPKAAGGAGAKGGAAGSGTVTVPMQGTIVKVLVSPGQDVEVGQPVVVLEAMKMENNIAAETAGTVQEVRVSPGDAVGAGDVVAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV6</accession>
    <name>A0A7K0JXV6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein GHK86_18890</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001211">
        <property type="protein sequence ID" value="MST34780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="9482" checksum="C14048CACACDB665" modified="2021-04-07" version="1">MVLDPLLLEILACPEDKGPLLYFADEQSLYNPRLRRRYAIRDDIPVMLVEEAESVTDDEHGRLLAKAEQEGIRPTFEPDAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW2</accession>
    <name>A0A7K0JXW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000962">
        <property type="protein sequence ID" value="MST34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="18601" checksum="9A85D055FE922A78" modified="2021-04-07" version="1" fragment="single">MPERLARQLTFCLELDRAKAVERHNTLADGSRREGDAEHMWHVAVMAAVLAEHADEPVDAARVVLMLLLHDVVEIDAGDTLLYDEAGRAAAAAREAAGASRIFGLLPGDQGVALRRLWEEFEAGETADARFARAIDRLAPMLLNAAAGGSVWRAHGVTAAQVAGNEARVAAASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW4</accession>
    <name>A0A7K0JXW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001223">
        <property type="protein sequence ID" value="MST34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="202"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="342"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="577" mass="60550" checksum="74752F8DAD9B308E" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY36</accession>
    <name>A0A7K0JY36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001269">
        <property type="protein sequence ID" value="MST34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="24020" checksum="5620FBB92223E728" modified="2021-04-07" version="1">MAGSVTPLQPSTTAPTRRSRARRGEGERLRDEILAAAEALLIATNDESALSIRAIAAAVGVTPPSIYLHFADRTELVFAVCERHWLQLEEAMEDAAAGVADPIERIRRRGEAYLRFGTEHPEHYRILMMSRPDDTPQRFTDERLAGTAGIEVVAADLQQAVDAGLLPAQDAREAAILLWMAVHGMVALLIAKPDFPFPPVEDLFDHFYRLTVAGLGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY52</accession>
    <name>A0A7K0JY52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA ligase</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001268">
        <property type="protein sequence ID" value="MST34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="1">
        <location>
            <begin position="12"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="24665" checksum="08C1D255F2ACD0E9" modified="2021-04-07" version="1" fragment="single">MRLPVMPPVSPMLAKLARELPEGDWRYEPKWDGFRCIVFRDGDEVELGSRNERPLTRYFPDVVAAVRERLPERCVLDGEIVVAGPHGLDFDALSQRIHPAASRVATLAERTPAAVVAFDLLCLGDDDLRAAPFDERRTALEGLLTASTAGVHLTPLTRDRAVAAEWFTRFEGAGLDGVVAKRPTQPYLEDQRVMVKVKHERTAEFVVGGFRWYKGQTGVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY83</accession>
    <name>A0A7K0JY83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001030">
        <property type="protein sequence ID" value="MST34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="13375" checksum="FDB0A027CDE62F1D" modified="2021-04-07" version="1">AALRAVARYTDTTTGTARVVTATELGAPGISRVSTARAGAGQTVTVTGSGFGATQGTSSALTLSDDGTTWSAPGNLPTLTVLRWSNDRITFRVPTGSGASGDQYHVVPGTDASLQVTTAGGTSNVVHLGITAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY97</accession>
    <name>A0A7K0JY97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001312">
        <property type="protein sequence ID" value="MST34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="62" mass="6257" checksum="952E5CD16F1CEC6E" modified="2021-04-07" version="1" fragment="single">MATSTVEAALERVTAALAGHEARPSQVAMAEAVAAAVARQRHLVVQAGTGTGKSLGYLVPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD2</accession>
    <name>A0A7K0JYD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4389 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001326">
        <property type="protein sequence ID" value="MST34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025498">
        <property type="entry name" value="DUF4389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14333">
        <property type="entry name" value="DUF4389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12675" checksum="380579DC96A41C94" modified="2021-04-07" version="1" fragment="single">QHLSRGLVLVKWWLLALPHYLVVAVFVGGFGFGWPEGTRVAGGISLIALLALIGVVTLAVRGRYPESVFDLVMGLNRWCFRVLAYVALMRDEYPPFRLDTGGTDPGHRPGRTPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ3</accession>
    <name>A0A7K0JYJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001323">
        <property type="protein sequence ID" value="MST34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="16131" checksum="1DB44DEE8FBF2AC1" modified="2021-04-07" version="1">FAEVVAPIRALAAAHGDRVVCTRFVAPAEPSGAWVDYYRRFPWALLPPRDPAWDVVDELADVAAAGRILSATTFGKWGPELAAIVGPDARLTLAGVSTDCCVLSTALAAADAGVAVRVVPEACAGADDAGHERALATMALYAPLIRVVPLAELLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN3</accession>
    <name>A0A7K0JYN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11 12">Xylose isomerase</fullName>
            <ecNumber evidence="4 11 12">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xylA</name>
        <name evidence="15" type="ORF">GHK86_19965</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="4 11 12"/>
    <dbReference type="EMBL" id="WJHE01001346">
        <property type="protein sequence ID" value="MST34992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013453">
        <property type="entry name" value="XylA_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02631">
        <property type="entry name" value="xylA_Arthro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="14">
        <location>
            <begin position="47"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST34992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="43529" checksum="360D67E44C13CCAD" modified="2021-04-07" version="1">MTVAAPSLPHPGPSDRFSFGLWTVGWQARDTFGDATRPPLDPVRAVHRLAELGAWGITFHDDDLVPPGSTVAEREATIARFRAALAETGLVVPMMTTNLFTHPVFKDGGFTSNDRAVRRYALRKVMRNLELAAELGAGTYVFWGGREGSEFEGAKDVQAALDRYREAIDTLAGWVRGQGWPIRFALEPKPNEPRGDILLPTVGHALAFIAGLEHADMVGVNPEVGHEQMAGLNYAHGVAQALWAGKLFHLDLNGQRSIKFDQDLVFGHGDLVNAFFLVDLLEHGAPGGGPAYDGPRHFDYKPSRTEDDEGVWDSAAANMRTYLLLKERAASYRADPAVAEAMEASGVTSLATPTLDPGETAADLRADTAAWEGFDADKAGERGYGFVRLNQLALEHLMGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP2</accession>
    <name>A0A7K0JYP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">GHK86_20245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="WJHE01001384">
        <property type="protein sequence ID" value="MST35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="15834" checksum="D48CA303B4574A9D" modified="2021-04-07" version="1">MSKGGAPQLEVRAEGLRVAVVAATWHQRVTDGLLAGARRALQEAGVADPTILRVPGAFELAAAAARLAPAHDAVVALGVVIRGGTPHFEYVCQAATVGLTEVSVSTGTPVGFGVLTCDDEEQALDRAGLPGSSEDKGHEAAQAALAVAVTLRQAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH5</accession>
    <name>A0A7K0JZH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001677">
        <property type="protein sequence ID" value="MST35371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12101" checksum="E87BD0430BBC9D7F" modified="2021-04-07" version="1" fragment="single">MLADRRPPEQGADGWTPQTPVVVAAGQPARVWIDVTNDSNVIEGVLADVEVPEGMTARVFEPEGPLFLFPDRKGPIGVELQVGRTFAARAEADPAGAVLVHLHSSHGRAGRDAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZJ1</accession>
    <name>A0A7K0JZJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001350">
        <property type="protein sequence ID" value="MST34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="195" mass="19742" checksum="21E7F06161B770A3" modified="2021-04-07" version="1" fragment="single">MLATVSSATLLGVDGCPIRVEVHVGSGVPSFTIVGLPDATCREARDRVRAALLSSGFRWPQHRVTVNLAPTAVRKGGAGLDLPIAIGLLGADGQLDPDRAARIAFFGELGLDGSLRKVTGILPLVAAAAERAVVVPAGCAAEAALPGRAAVLPALSLRNVVLALCGEDSWAPVPAAEPAGPPVDEGDLADVRGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZM8</accession>
    <name>A0A7K0JZM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001647">
        <property type="protein sequence ID" value="MST35343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="205" mass="22462" checksum="CBC043BDA17B2220" modified="2021-04-07" version="1" fragment="single">PPLSTDEYLPAGRHSSTAGGKRLTPRNLKAAATRERIIAAAAAAFDERGYLGVNLREVVQDLGLTTGALYYFFKTKEDLAVEIVERHFAGWDDLVAEVVAHSTSRLDALVEVTYRVADAFTSDLVVRAGARLSAEREVIGAELHRPYADWTTRLAAGGPWGPAVSSGPMDPGDRSPSDDRSQVADERDRHADERDRHADERDRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0A5</accession>
    <name>A0A7K0K0A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001537">
        <property type="protein sequence ID" value="MST35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="71"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="434" mass="47013" checksum="CCF79B703988AD2F" modified="2021-04-07" version="1" fragment="single">MVDPQAASSTSAPSSAGSDHHRRTSDTVGAVAPAVTSPRPGRVGAAGGVGEKAKGNHEGVPTTRRLTNEPGLDGIRGLAIVLVMMVHIGVRQGGFVGVDLFFVLSGFLITTLLLQERERSGRVSFRRFYLRRAFRLLPALGVAIVLGDVARRVLPYRVEQAPYWAVSLAALLYVTNWVQLADRHAIRLLAHTWSLAVEEQFYLVWPASLLLALGRWRREVRTVLTIVGAVTAASLLSLVIGFRVSPDANLYVATTSRAGELLLGAALSVLWRHRRVPRVLSAPLTGVAALAALGWVFETASEGTTWLYAWGGLYVAAAVGVVLVATVIERPQSPLTRLLRAQPLRYTGRISYSMYLYNYPLTFILSEPVIGIPTVYCQVLMLAATWLLASVSFFVLERPIIAWGRRHEPRGPEPREAEGPAAATIPAGPPTHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0D9</accession>
    <name>A0A7K0K0D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001544">
        <property type="protein sequence ID" value="MST35239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="10590" checksum="5CD1D8827639467C" modified="2021-04-07" version="1" fragment="single">APLLAATGVALRTAARSLRRRHDATHDPLTGLANRRLFDQELAAALRSGAPEDDHVALVLVDLDGFKGINDSYGHEHGDRVLVEVAARMAAVCRPSDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0G4</accession>
    <name>A0A7K0K0G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosamine-6-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001583">
        <property type="protein sequence ID" value="MST35284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="28439" checksum="6160FE4F6451DD8E" modified="2021-04-07" version="1" fragment="single">MVVLGHTRWASVGVISEPNAHPLNSDELTRPSGSYVAAALNGDVDNHHDLRAEHALALPDEISTDAKVIPTLAARRLADGAPAGEAWLETVRRLEGSVAVAASLAGEPDRLHLALRGSGQALYVGLAEDAFVVASEPYGLVQETARYVRMDGEATQGQVLVLERDGAGTLAGMERRRYSGAALPLAAEEVAAAGITTRDIDRGGFPHFLVKEIFQAPGSLRKTLRGKVLPLPGGRLGVGLAPDTLPAEVVDALAAHRIRRVAVIGQGTAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JME8</accession>
    <name>A0A7K0JME8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000002">
        <property type="protein sequence ID" value="MST31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="66"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="440" mass="47801" checksum="267079E4D09244C4" modified="2021-04-07" version="1">MQVKAARGACARPATVKGVDSPPVPGLLLRDHHTEVPLDHADPGGPTISVYAREVRAVERAADDLPWLLFLQGGPGGKAPRPTDRSGWLGEAVKDYRVLLLDQRGTGRSSPVTERTPGRFADDRALARYLTLFRADSIVADAEILRARLGGGRPWTTLGQSYGGFCTFTYLSSAPQGLERCLVTGGIPGLEASAEDVYRRTWARVLDKNAEHFRRYPADRSLLNRARDAVAGGRVLLPGGDVLTVARLQALGIVLGMSYGSAQVHYLLEEAFDGDELAPAFLAEVEQQTGHASNPLYAVLQEACYCSGTASRWAAQRVREAEFPEASPDATDLLLTGEMKESWVFRDEARLAPFAGAMELLHAKEDWPALYDPGRLARNEVPVAAAVYHDDLYVDAGLSLATARATPGVRAWVTNEYEHDGVRADARVFSRLRDLATGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMH9</accession>
    <name>A0A7K0JMH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminomethyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="1">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="467" mass="51948" checksum="212D017DB8464D9C" modified="2021-04-07" version="1">MASNLQQLLDQSGNVVDLLRNSQLGAYIYPVVPAEFTNWRREQRAWRETAVLFDQSHHMFNLFLRGPDALRLVSETGVNSVASFPVDRAKQFVPTTPAGHVIGDGILFHEEEDAYVFVGRAPVANWLQFQAETGGYDVEVIKDERSPSRPYGKAVSRRYWRLQIQGPRAWEVIEKVNGGPLEQLRFFHMSWMQVAGERVRTLRHGMAGAPGLELWGPYDSYEKVRNAILEAGAEFGLEPCGSRAYASNTLESGWIPSPLPAIYTGEALRPYREWLGVDSYEATNSLAGSFVSADIEDYYLNPWELGYGSFVKFDHDFIGREALERVDGAAQRKKVTLAWNAEDVARIFASMLDPDDEGYQVFDVPIANYGSSNYDAVVDADDTVVGLSMFSGYSANEKRALSLATVDAGVPLGTELRVIWGEPGGGSRKPTVQPHRQIEVRAVVSPVPYSVTARREYHGGWRTAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMI7</accession>
    <name>A0A7K0JMI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000013">
        <property type="protein sequence ID" value="MST31170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="27151" checksum="E09AC15CD0075CE9" modified="2021-04-07" version="1">MRPGPAPRRPFDLTGHVALVTGAGSAAGIGFACARALGLLGARVAVASTTDRIQDRRRELAAEGIEAWAGVADLTDEAEAVRLVAEAREAVGPANIVVNNAGMTSVSAPAVEAALGTLGRRDWHEAIERNLSSAFHVSSAAVGVMVEAGWGRIVNVASVSGPVAAYPGDVAYHAAKAGMVGLTRAAAVELAGRGVTVNAVAPGWIATATSVREDRMGAATPVGRSGTAAEVAACVAFLASPDAGYVTGQVLVVDGGNTIAEERGAGDLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JML4</accession>
    <name>A0A7K0JML4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MarP family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000018">
        <property type="protein sequence ID" value="MST31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="391" mass="39427" checksum="D2E149D317738430" modified="2021-04-07" version="1">MDALDGILLAVAVLAAVGGYRAGFFTRVLSWVGLAAGVYLAARYLPRIVSLLALSSATSRLAVAAAVLVGAAFVGQAAGILLGGRLHGVLPLGPLRSFDKLVGGAVGVVGVATALWLLLPSISSVPGWPASAARHSSIARWFSGSLPPPPNALEALRRLVADDGLPQVFASLHAGGAVGRPPASSPLPAALLARVEASTVKVQGQACNRIQDGSGFAVAPDLVLTNAHVVAGEPAGATSVLLPDGSTLPASVVMYDPNRDLALLRVPGLGERPLPLATARVGGRGDVLGHPGGAIHLAVSPYVVSQEITAVGEDLYDRHRTRRDVFVLGAALAPGDSGGPLVDVHGRVVGVAFAIAVGQAGTAYALTTHEIRPDLAGTHPHAVATGACLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU4</accession>
    <name>A0A7K0JMU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000016">
        <property type="protein sequence ID" value="MST31197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="12233" checksum="21627E520C641F82" modified="2021-04-07" version="1" fragment="single">MLVGTELAPARAGAGALETLLDGWAAALAAGGDDLHLVGAPGTAAGSDAAVTRHELAHHPAGLDALVARLAPDVVVLNNRPAWQPLVRTAALHLMHNWPDAWQLGERPPAALVGQASAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX4</accession>
    <name>A0A7K0JMX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000017">
        <property type="protein sequence ID" value="MST31201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="22205" checksum="24FCED361D31E744" modified="2021-04-07" version="1">MVCYRCSVGTDSNRHRPRYGEGREALLEAAIRVVARGGLRQLTYRAVAGEAGVTHGLVAHHFGSRDALLEEALRYALAKSVATTSLESGTTNIADFARELVATVRADPDLQAFQYELLLEARRQPQLRRYAEELYDTYRDATRRQTKALGLDDDAFADVVFAALDGVVFQLLATDDADTADGTLERLRHLISNLLTQASHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX9</accession>
    <name>A0A7K0JMX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000035">
        <property type="protein sequence ID" value="MST31305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="19579" checksum="620571527F3EEA31" modified="2021-04-07" version="1" fragment="single">MLPSSVRPTAGTDPAIIQGGMGVGVSGWRLARAVASSGQLGVVSGVGLDTQLARRLQLGDPGGHLRRGLAHFPFPGVAEAILERYYTPRRPGPGQAFRPAPVSSLRASKAAAQLVVAANFVEVFLAKEGHGGRVGVNHLEKLQMATPAALYGAMLAGVDYVLMGAGIPTEIPTLLTDLAAGRPGRVTVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMZ7</accession>
    <name>A0A7K0JMZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3459 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000040">
        <property type="protein sequence ID" value="MST31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="16"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="558" mass="61354" checksum="A047CE8E53B99262" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN91</accession>
    <name>A0A7K0JN91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="34391" checksum="506A94947BF426D1" modified="2021-04-07" version="1">MGDLLDRRLIFVTGKGGVGKTTVAASLALLAAQRGRRTLVCEVDAKGNLADFFETGPTAFEEREIAPDLWAMSMDTEASLRQYLSLQLKLPLVARIGPLAKMFDFVASAAPGVREIVTVGKLCWEVRERHYDTVVVDASASGHIVSQLAAPQAINELVQVGLVRQQTGWMLDILGDPATTGLVVVATPAEMPVTETLELVGHVEQDTNVDLAAVVVNRVLPELFSRSEEELFERLDTDEPRAALDAALESSSRPLLDAARLMVGTRRSRTEHLERLRTGIESRVPLLYVPYLFIRSHGLRATHQVADALAAELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN96</accession>
    <name>A0A7K0JN96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IS256 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000064">
        <property type="protein sequence ID" value="MST31425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="49" mass="5882" checksum="5FD348DEF2FFD4A8" modified="2021-04-07" version="1" fragment="single">MPASLFSYLRFPVEHHKRIRHSNFIERTFGETRRRVKVIGRLPGERSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ3</accession>
    <name>A0A7K0JNJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000094">
        <property type="protein sequence ID" value="MST31542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16837">
        <property type="entry name" value="BldD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038099">
        <property type="entry name" value="BldD-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037664">
        <property type="entry name" value="BldD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="17489" checksum="E30D584E5620662A" modified="2021-04-07" version="1" fragment="single">MDEEDVSPAYAREVGNRLRHIRRQQGLSLQAVEEASKREFKASVLGAYERGERIVSVLRLQRLAGLYGVPVDQLLPRAPGSPGVNVDGATGLSRDVAPVRIDLARLDQLEAPERDLVRRYIGMIQIQRGDFNGRVITIRNEDVRALARVFERDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ9</accession>
    <name>A0A7K0JNJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="372" mass="40364" checksum="37B3C3557319A4E2" modified="2021-04-07" version="1">MSSVTRVPKSHNPILGAPSRLKLAVFAINCSGGSSMSDVPGVVQVEWQEQIAIARAAEEAGFDALVPVARWKGMGGRVNFNHRSFEPLTWAAGLAASTTRIGVFATSHVPTVHPVRLAKTVATIDHISGGRFTLNIVAGWNTQEIGMFGLEQLEHDERYDFADEWISLAKALWSTEGELDWEGKYFRAPGAYSEPKPLQEPCPVLMSAGSSPRGQDFAAKHTDVIFVATADAESSGRMAESVKSLARDHYDRKVSVFGQVFIICDDDGDVARARFDELVHERGDWEGVQNLLDILVPNSRSADWSALAANLIGGYGAMALVGTPEEVVEGIADLAEAGLDGLTMSWPDYLEGIRQYRDVLRPRLVAKGLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP0</accession>
    <name>A0A7K0JNP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="6" type="ORF">GHK86_01960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000083">
        <property type="protein sequence ID" value="MST31497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14416" checksum="3CB1C201AA26FFC6" modified="2021-04-07" version="1">MSQLLLETTFLVDADRRRSALDDVIADDDDAAIAAITVAELLVGVHLADDVHRPDRQAFVDDVIDVVPIVDYDAAVASSHGELLAFVRRQGRPRGAHDLIIAATARATQREVVSAGSSAYRDLPGVVVRPHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP39</accession>
    <name>A0A7K0JP39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop NTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_02935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000115">
        <property type="protein sequence ID" value="MST31683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="3">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="29622" checksum="AE3A54DC2FCDE50D" modified="2021-04-07" version="1" fragment="single">MAPLDEATVRAAMRGVIDPELGADVVDLGMYQGAEISPGGHVTVRLALTTAACPLRGQLQRDVDARIGSLPGVSSVVVSTGEMGREQRRELMDRARARAQEQAPTTSIPARTRVLAVSSGKGGVGKSSVTVNLAAALAAAGRRVGLLDADIAGFSVPHMLGLEGRIEATRTSDGEGSERLRLVPVTMPVGDGHLEVLSMGFLSGEDEAIMWRGLMLNRAVQHFVEDARWGDLDYLLVDMPPGTGDIQMGLARLLPRAEMLIVTTPALAAQKVAARAADMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP52</accession>
    <name>A0A7K0JP52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="26266" checksum="BD3A3EDF86B8DCF9" modified="2021-04-07" version="1">MMVVDGKVVLDCLDELVDPCHTALVIIDMQRDFVAPDGVFGRLGVDLSMYPPMRRRLVRLLGAARGAGVLVVHVAMTSLPGRRSDSPAQIRFNLRMHEGVRAGGPPLIYTVAGTRGHEFVDELVPWPDEPVVSKHRSSAFWGTDLAMLLRSNGVQTVVAAGCTTEGCVESTARDALFEDFYTVVAEDGVASDDVEQHAASMLLMRHRFDLATCAQLAAIWSPASSHEVGDRERAVGSGLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB3</accession>
    <name>A0A7K0JPB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000126">
        <property type="protein sequence ID" value="MST31727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="120"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="33937" checksum="486B705FFAD31BF1" modified="2021-04-07" version="1">MAPGDPTSTSASVSDLESLIPAWVRSLRAENKSPKTIETYGDAATQFQRFLVAHGMPTDATRLTREHVETFVASLLERHKPATASNRYRALARFFAFLVEEGEITASPMARMSPPAVPEEQVAVLSDDELRRLLTAAGGKDFDARRDTAMLRLLIDTGMRAAELMGLGLDDIDLDLGVAIVLGKGRRRRSCPFGARTAQAIDRYLRARGRHPAAASERLWLGRAGPMTYAGLRQMLDRRAGQAGIGHIHAHQLRHSFAHTYLAQGGNEGDLMQLAGWRSRAMLNRYAASTASERAREAYRRMGIGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL1</accession>
    <name>A0A7K0JPL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000169">
        <property type="protein sequence ID" value="MST31900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029851917" evidence="2">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="10554" checksum="032A5B6A89BBB777" modified="2021-04-07" version="1">MILSLRDAGLSTRAIGAALGVSNATVSRTSAVTNETPAPVVGRDGKQYNPKPKPEASPDTAKAAPDVPDLADMLADQEQQDALREVGLASDDTDMTAESAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL3</accession>
    <name>A0A7K0JPL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000082">
        <property type="protein sequence ID" value="MST31494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="55"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="251" mass="24966" checksum="BD89FBC1FED2A683" modified="2021-04-07" version="1">PAVGAVASRVGTRPAFAAATVAGVCLIVATLAVPSQRSEESPSLRHAVRALRDLRLGAGLWLTFLAGLAFGTVSVLAPLRLSRLGAGALLIGATFLGAAAVETAAAPVIGRIADRRGRRRPVTVAVAAAIAASALIPLAAPASVLVIVLVAGLPSYGALYVPAFALASDGAQRRRLHQSLAFGLSNFAWAGGQAAGSAGGGALAQAVGDALPFTLLGIAFAVTLAMLSPAGRRVVSRVFADTTHGGRAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ37</accession>
    <name>A0A7K0JQ37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000202">
        <property type="protein sequence ID" value="MST32062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="638" mass="67816" checksum="C4BDCC94EBB36D8D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ48</accession>
    <name>A0A7K0JQ48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000117">
        <property type="protein sequence ID" value="MST31689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="25734" checksum="FE89B21EB52431D7" modified="2021-04-07" version="1">MTGQEPEPIRGAISLEQRPDSLTYSVYEAIKQAILDGRLAADTRVTEAALARQLVVSKTPVREALLRLKEIGLVEADGPKGGRIVRPSFNRLRDAYEVREALEAISARAAAERGDRTLLLAARQKAEATVEAADAGDLEQYQRADEAFHRLLAEAGANERLARLIDDTNVLAGVLRQRDTPEMGASPVCARRHVAIADAVLAGEADEAFRLMATHVREVREAVLAPMVERGQGAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ60</accession>
    <name>A0A7K0JQ60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="9" type="ORF">GHK86_05010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000209">
        <property type="protein sequence ID" value="MST32086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="7">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="7">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="7">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="7">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="30699" checksum="FDE0A2F2E4B40F1E" modified="2021-04-07" version="1">MTGDGTYRSGFATLVGRPNVGKSTLLNAVLGQKVSITSPVAQTTRNQVRGVLTRPGLQIVFVDTPGIHKPRTLLGARLNDTANDALAGVDVTVLVLDATQPLGRGDRFVADLVPPSALCVVNKVDAAPRRVVLDQLQAAAGLGLEEYFPVSARTGEGVGALLEAIVTRVPEGPQLYPDDMVTDVPEAHWVAELVREQLLAVTREEVPHSIACRVTEWEWPRVRCEVLVERESQKPIVIGRGGSVLKEVGTRVRAQLPPGAYLELFVKVDPGWQSRPKALERLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ86</accession>
    <name>A0A7K0JQ86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="21771" checksum="40FC0856B28DBA69" modified="2021-04-07" version="1">MRAALPDDAERIGLAHVRSWQAAYAGHFPQEFLDGLDPARRAEGWRRRLEGSLPDREALLVAETSTGIAGFASVGPCRDDEIGAGGLYAIYLLPEVWGHGLGRQLMVASLEAPGRFDFDEATLWVLTGNGRARRFYEAGGWQVDGATKVDEGPGFPIAEVRYRVALPEGAPCAATGSPRRWPGAHGSRQPARGPDLPTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA4</accession>
    <name>A0A7K0JQA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succ_CoA_lig domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000219">
        <property type="protein sequence ID" value="MST32135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Succ_CoA_lig" evidence="1">
        <location>
            <begin position="55"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="21578" checksum="485C2E88FB20A39E" modified="2021-04-07" version="1" fragment="single">AAAGLGELGGEGAVQEAAIGEVAAGAGMRLLGPNGFGLFVGGLGLNLMAWRDLPAGRVALVTQSGNLAIALSRLMAHAGIGLASCTGLGNQLDLTAADIVAHHAADPGSDAVALYLEGLRGGEGRRLLAALEACRDRGKPVVVVKGGRSAAGARAAATHTGALSGDGRLWDAALDAAGAVTVDSPEAMVDVLAALAALGARRAGPGRGAPAAVVLTDGGGDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF9</accession>
    <name>A0A7K0JQF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_03600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000143">
        <property type="protein sequence ID" value="MST31814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="381" mass="41074" checksum="38A9E10C2A52F2C6" modified="2021-04-07" version="1">MQPITLTPEQREFRAAVRALAEERIAPRAAEVDATGEFPWDNFKDCLAMDLPGLGIPEAYGGSGADHVTQAILVEELARVCGSTSLIFAVNALSTLPIINWASEEIKARYLPPIARGESQGSYCLSEADAGSDAAAMKARAVRDGDEYVLSGSKYWITNAGVSDIYVVFAKTEPEAGPRGVSCFVVEKDMGLRFGKLEKKLGMHGSPTREVILDGVRVPVANRVGEEGQGFRIAMHTLDRSRTGIAAQAVGIAQGAIDVAKGYMRERKAFGQAIAEFQGLQFMLADMAMRTEAARLLTYKACALIDEGDPDGELTVAGATAKCFAGDTAMAVTTDGVQLLGGYGYTQDFPLERMMRDAKITQIYEGTNQIQRMVVARQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG6</accession>
    <name>A0A7K0JQG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gpmA</name>
        <name evidence="6" type="ORF">GHK86_05575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="WJHE01000238">
        <property type="protein sequence ID" value="MST32195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="230" mass="25722" checksum="B9FA11FD344E1AB3" modified="2021-04-07" version="1">MGSLVLVRHGQSRWNLENRFTGWWDVDLTAAGEEEARRAGRHLADAGATPDVVFTSVLRRAVRSANLVLDELGRAWIPVERHWRLNERHYGGLTGLDKAETEARHGREQFLAWRRGYATPPPPIEPGSEFDVRQDPRYAGFGRDIVPATECLADVVARMVPYWQDRIAPEVLAGREVLVVAHGNSLRALIKHLEGISDEDIPALEIPTGVPLVYELDGALEVKDKRVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ1</accession>
    <name>A0A7K0JQZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="115"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="441" mass="46835" checksum="F533F37C0AACDB80" modified="2021-04-07" version="1">MYGPGLPRAGGQVDRPPLGGVRGASLPTGGSRRGGGRPARHRVGRLPVPLDRAGVRGIPQGSSAAAVRLPDPVPGGPRGGGDLGRRGVPRAAPGRAAADHEPMTTPRSADPTVAVVIPTFNRRALLLEAVASVLGQSYDRLVCLVVDNGSTDGTKEAVEAIDDPRVRLLALPAPVGGPAARNVGVEAADGAGWVAFLDSDDLWAPDKLQRQMEALGRHPGVAWATTAAASVTEDLRLLQVHRVPLPIKALGGVECLGADRLRPLMVEDNIVPAGNTTVIASRSLLQSVGGYDEHLRTCDDWDLWLRLGSRSPLLYLDEPLAAYRTWGGQASALDRSFVSDAAAVRTRHFPEAGPLPTSYQVTWEQALARRDVVARRRLSASRHYVRAALLGRSPGQLAYAVAGAVAPRSTERRLLRLDRADPALAEWEARAESWLAGARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR82</accession>
    <name>A0A7K0JR82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000294">
        <property type="protein sequence ID" value="MST32445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25900" checksum="59F99A486B1DB68F" modified="2021-04-07" version="1" fragment="single">MTPAPHLPDDLGGLLAPYLARQRWYAGPEDLDPGEVRVVETRELCSTGGGQRHLHLAVVDAAGSRYQVLVGERPAGEHAEFLQGHADSMIAGLEGRYLYDAVVDPELARELLPIVTGGVEAATLVRPVGAEQSNTSLVYDDRIILKVFRRLVAGRNPDVEVTTALARVGFEHVARPVGVWRSGDLDLAFAQEFLAGGAEGWALALTSLRDFYDSGDPEPAAAGGDFSGEARRLGVVTAQLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR89</accession>
    <name>A0A7K0JR89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000295">
        <property type="protein sequence ID" value="MST32450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="312"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="393" mass="41994" checksum="92C5304DF2C31873" modified="2021-04-07" version="1" fragment="single">LRAAIVVDRLGLEPPAGAHRWSDAVSGDTPPSPVAVPFDHPLWVLFSSGTTGRPKGIVHGHGGVVLEHLKEVALHADLDAGDHFLWYTSPSWMMWNYQVAGLLVGATIVTYDGSPSWPAPDALWALAARTQVAMLGTSPAYLLACEKAAVHPAADHDLSALRLLGITGSVLPATSFRWAERELGEAVTIGSISGGTDVVSAFAGSAPGIPTRPGELAVPHLGVALDAWDPAGRPVRGEVGELVVTEPMPSMPVAFWDDPDGSRYREAYFAMYPGVWRHGDWITITEGGSVVIHGRSDSTLNRNGVRMGSAEIYQAVEALPEVVESLVVGVEQPDGGYWMPLFVVLAPGAELDDDLRARIRQAVRDRASPRHVPDDVIAVRAIPHTRTGKKLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH7</accession>
    <name>A0A7K0JRH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">rplV</name>
        <name evidence="13" type="ORF">GHK86_07230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000315">
        <property type="protein sequence ID" value="MST32513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="28285" checksum="0E4F9A58A1A6C123" modified="2021-04-07" version="1">MPGPKTNERPGTKAVLRHSRIAPNKVREVLDLVRGKPVNEAEAILRFAERDAALVVGKLLHSAVANAENNDDQEAEELYVSACFADEGTTIKRWRPRARGRATRIRKRTSHITIIVSRMPSEQLERMRARRRAEQLAARERRVRSSRSAGDTRSRAQRRAGVPMEEPETEETTTEATASDAPSFAPGAEEPSAAEVAAAADEEGIVDTEALAVAEAEAGEVIETAADREAQAAAETPAADEAQAAEEPATTETAAEDGGEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ0</accession>
    <name>A0A7K0JRJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="13" type="ORF">GHK86_07330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="WJHE01000323">
        <property type="protein sequence ID" value="MST32533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="157"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="330" mass="34256" checksum="FCA3B111CBE34756" modified="2021-04-07" version="1">MPASPVRVAVTGAAGQIGYSLLFRIASGQLLGPDQPVILQLLEVTPALGALRGVVMELEDCAFPLLAGVTTSDDANVAFGDAEIALLVGARPRSKGMERKDLLEANGAIFTVQGKALSDNAAAGIRVLVVGNPANTNALIAQQSAPNIPAERFTAMTRLDQNRAKAQVAGKVGVPVTEVRDLAIWGNHSATQYPDLFHATVGGRPAMDVIGDRTWMEKEFIPTVQQRGAAIIEARGASSAASAASAAIDHVHDWVLGTGDGGWVSMAVPSDGSYGVPEGLISSFPVTCAGGQWSIVQGLEIDEFSRGRIDASAAELGEERAAVRELGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK6</accession>
    <name>A0A7K0JRK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000248">
        <property type="protein sequence ID" value="MST32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="202" mass="21436" checksum="ED5EEDA054BEF9B3" modified="2021-04-07" version="1">MRRKVFDLLASAGGIVIALILVVAGALAMWGYSFTNSSVHDQLARQEITFPPASAFAHPKAGTEITPSMIPSVSQYAGQQLLTGQQAKVYANDFIAVHLSEMPYNGVYSKISAAAMAQPNNASLKALQQTSFQGTTLRGLLLEAYAFSVFGTIAFWAGIACFIAAAVMLTLVGLGFWHAHRTAEEEEILVHHAPVGGTPAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV5</accession>
    <name>A0A7K0JRV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-erythro-3,5-diaminohexanoate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="351" mass="36045" checksum="9E66B818C9F03BCB" modified="2021-04-07" version="1">MDGLPGRVQGLAFADPAAVGSWRSRWPVGALPHLAQRLDADSPANEFEAEVDVELLNIDATSFRQLCAQEGGRPEGIALAIERIVGERGKMHNPVTGSGGVLLGRLAGVGSRRGGEASLGERVVPLASLIATPLRLESVGPVDPRSPQVPVRGRAVVTGRMSLAPVPDDLPLEAVLTAIDVYPAASHTRALAGPGEHVLVIGAGHGGLAAAVAAREAVGTEGRVTVVDRDPRALLSARAVDPLAVTVEADATDPTGVAERMGTAGSGPAHLTVSCTTVPGCEGTAILLTRDDGTVLFFSTATSFSAAALGADALSARTRLVIPNGYTADRGGYLLDLLRRHPALLRAYSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX2</accession>
    <name>A0A7K0JRX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000359">
        <property type="protein sequence ID" value="MST32680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="47" mass="5094" checksum="43870CF8EA7818E6" modified="2021-04-07" version="1">MVERGLMPLERWLLLPADSQETVLVVLARMISAGVVIAESDGEGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX9</accession>
    <name>A0A7K0JRX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000356">
        <property type="protein sequence ID" value="MST32673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="13588" checksum="FBE68AF112228DE8" modified="2021-04-07" version="1">RSTVATGAGEGGEPGEAGEAGEATFERLNTWYFADAPRQVRPVLEASRRVTAFDEVVGGLDTDSALFEARRCLSCGACLGCDNCYGVCPDNAVRKLGPGRYAIDLDYCKGCGLCVAECPSGSMALVPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS78</accession>
    <name>A0A7K0JS78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="6" type="ORF">GHK86_06755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="13032" checksum="51331B79FE61F573" modified="2021-04-07" version="1">MRPYEVMVILDAGLEEDVIRATIDRATQLVTAGGGTVGRVDRWGRRRFAYEVHHRSEGYYAVVETTAEPAVMADLDRMLGLADEVVRHKVVRLPDKVAGRTLRPVLAEDAGADSNANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS95</accession>
    <name>A0A7K0JS95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YihY/virulence factor BrkB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000399">
        <property type="protein sequence ID" value="MST32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="342" mass="36322" checksum="18EBCA8EA7CA2222" modified="2021-04-07" version="1">MTRAVRGQNGVVERVRRLLARLDRRQQRHRVLAVPWAVQRKFGDDQANLLVVALGWYGFTAIYPLLLAVTTVLGFIGVRSLGAGVVRTLHQFPVIGEQFSVSGGRTLHGSPLALAIGLAGLLYGAQGVTQTAETAMNRVWNVPQVDRPGFLPGLGRSFGALAGIGFAFLANAFAGGLATSSGHGLGWRVAIIAGQLVLNVGLYLLTFRLLLAGPARARTAALVPGAVLGGVAFTALITVGTGLVQHQLRHQSATYGAFASVIGVVLFLLLLAKLSLYAAELNPVLARRLYPRALPMCEPLPADRQVLTARVREQRQRDDEHIRVHFEGDGGTPAGRAGSGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD7</accession>
    <name>A0A7K0JSD7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_07060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000306">
        <property type="protein sequence ID" value="MST32479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="44"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="19944" checksum="00D89493EBFB5ACA" modified="2021-04-07" version="1">MTEPASGADPAEPVAAAAPAPTGRLAGLRQSPFVRKVTGYSAGSVIAAFTSEIAFAGSFGVLHVGTTLASLIGFVGGAIPNYFLNKRWAWKDQGSRSRRDEILLYALVSIAAFAASVVVTGYAERYARTLTATRGLQVVLVAAAYLAVSGVFFIGKFVAYELVVFTRGPGARKGSAGRRAAGATRSRRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH5</accession>
    <name>A0A7K0JSH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000423">
        <property type="protein sequence ID" value="MST32891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoeA_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="7715" checksum="EC33B7E2C62761C5" modified="2021-04-07" version="1" fragment="single">MISLEEARSRVLAGCRPAPPRPVAVADALGLVLAEDVDAGEAVPPFASSAMDGYAVLAADVAGASGDRPARLRVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH6</accession>
    <name>A0A7K0JSH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3147 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000420">
        <property type="protein sequence ID" value="MST32885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021493">
        <property type="entry name" value="DUF3147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11345">
        <property type="entry name" value="DUF3147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="11657" checksum="F3EE6E9671F504C9" modified="2021-04-07" version="1">MSIGILALRAVLAGALVVVFSLIGELTRPKAFSGLFAAAPSVATASLAVTLGFDTVARARSETVGMVLGGIGMAVCCLVASVAIPRLRAVIGSLAAWAAWGLVALGLFWAVFVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL7</accession>
    <name>A0A7K0JSL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2267 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000440">
        <property type="protein sequence ID" value="MST32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="14308" checksum="05E6C0E26F08235D" modified="2021-04-07" version="1">ATHAGVGAGAARPVVRAVLATFADRLPPAERDRVSAHLPADVRSLFEPPQRTGERAPARTVHELVVRVAATAGDEVSTHDAEPVTRAVIGAFRSLVPEERRDVAAVLPAELRALWEAPTVPPEPRPGTEPPQEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM5</accession>
    <name>A0A7K0JSM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">GHK86_09450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000438">
        <property type="protein sequence ID" value="MST32940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="553" mass="60781" checksum="8A07461D60A00A38" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW0</accession>
    <name>A0A7K0JSW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000354">
        <property type="protein sequence ID" value="MST32664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="24927" checksum="8AAC45C0E1C9D5E6" modified="2021-04-07" version="1">MPCHPTWETAGMDPRYNGVAVGDGNLDGKGVYATRDFAAGEPVVSYELVPLSREDFARLPAGEDLFVHSYGGRRWLYPPPARWVNHADEPSCFQDFARGCDTALRPIRAGEAVTIDACAETDYELSTFLDAYIGSRNARDTEALLELVDPQAVIWYRGRRVGGHHAVVDALIADGPIRLGRVEWLIGTGRWEALCSAECRDDLRHVTASLKVIAGNWQLVYEHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT93</accession>
    <name>A0A7K0JT93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000501">
        <property type="protein sequence ID" value="MST33147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="379" mass="43448" checksum="54DA014AF4950AF3" modified="2021-04-07" version="1">MSSAVEIRPVRHLLGRRVFVDVPFRIHGGDPGWVPPLRMSVHDRISPRHPAMSHQEVALWVAYRHGKPVGRIAACVDRAFNEYQGVRWGWVGFYDTFDDPEVSDRLFETACGWSAERGMDTCVGPANFTTNDELGLMVEGFDDPPALLTLQNPRYYEGLWLRAGWEPAMDLWGWHFVKGDVALSERQRRTIDRIQERAGVHVIQLEKDQFDSQVGRFFEVYNAAWSRNWGFAPMPEPEVRHLAKQLKQVLRPEWAFGLETDDGKLVGVCLALPDVNLLMHRVRSGRLLPTGWLPLLTGQKRLPRARIWALGVHPDYQPMALGTLLYREVFDRLGSDPHIRTGEASWTLATNKRINEQLEAMGATRSRVWRLYQRPARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC9</accession>
    <name>A0A7K0JTC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron reverse transcriptase/maturase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltrA</name>
        <name evidence="2" type="ORF">GHK86_10775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000520">
        <property type="protein sequence ID" value="MST33202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="30135" checksum="5EDF9B3997D7B92B" modified="2021-04-07" version="1" fragment="single">MGEEPTEGSKPNKRKSFDIEKRLVFGAWEKVRANSGAPGVDAVSIAVFGERWGDNLYKLWNRMASGSYFPGPVRAVEIPKDHGAGVRVLGVPNVADRVAQTAAAMLLEAKLEPVFHPDSYGYRPGRSAQDAVEVCRRRCWEHDWVIDCDIRAFFDSVPHDLLLKAVAHHTSERWVLLYIQRWLKAPMQMPDGTLVPREKGTPQGSPISPLLANLFMHYAFDRWMDREHPGFPFERYADDIVIHCDTQTQADELRARIAERLETVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG0</accession>
    <name>A0A7K0JTG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000521">
        <property type="protein sequence ID" value="MST33203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S53" evidence="2">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="320" mass="31283" checksum="44484AB233C9FFCA" modified="2021-04-07" version="1">GLGLPVPAVTAVGVDGGANQPGAPNGPDAEVMLDIEVAGAVAPGARIAVYFAPNTDQGFLDAVSTAVHDTTNHPSVVSISWGSAEIGWTPQAMTQMEDAFATAATLGVTVTVAAGDSGSGDGVGDGRPHVDFPASAPHALGCGGTTLELAGEAIRSEVVWDDLPSGGGATGGGVSAVFGVPAWQASAGVPPVPNSGGRHQPTGGRGVPDVAGDADPRTGYEIRVDGRTEAIGGTSAVAPLWAALIARLNQSLGRDVGFVNPQLYALGLPSGAAPDIVHDITVGSNGAWSAGPGWDPCTGLGSPDGSALLAAMQAPPATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ7</accession>
    <name>A0A7K0JTJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mnmA</name>
        <name evidence="9" type="ORF">GHK86_11140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000539">
        <property type="protein sequence ID" value="MST33271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="383" mass="39486" checksum="10A1EB80F5728FCA" modified="2021-04-07" version="1">MRVLVAMSGGVDSSVAALLLAEAGHDVVGATMKLWAGPSDAGCCSVADVDDARAVADRLGLVHHVFNFSADFDARVVDPYVADHAAGRTPNPCVECNRHLKFDRFLRRARQLGFDAIATGHHARVLPPGPDRPGRGWALARGADRAKDQSYVLHMLGQAELARVLLPVGELGKAEVRARAASAGLRTAAKPDSQDVCFVSGPGGRAAFLGARLPLRAGTVVDDAGRTVGRVDAVELVTVGQRRGLGNPGGTLPAGERRYAVDVDLRRAVVTVGAADRLLAGDVALAGLSWVDGPPEPGERLEVQCSAHGAPLAGVWEPTSRGTPSPGGSGVAPSGGSGGEAPRSAPGQGRIVWEVPSRRVAPGQSVVLYRRDLLVGGGQAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK0</accession>
    <name>A0A7K0JTK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_10990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="501" mass="53669" checksum="03CC459BA6F9B6C2" modified="2021-04-07" version="1">MTSGRAPATAEVANEAFRVEQRGIDLVPDDERTMRPRQLFWMWAGAIWNVEFLVYGALIVSFGLSFGQAVLAVVVGNLFYSLLGLLSLQGPEAGTTAFGVSRAAFGRNANRLPSLFNWFTQVGFEVEGLVIIVFVVEALLRRGGVQPGTGLKILVIVAAVAVQFIVPFLGHATITRVLNSLAIVFIVVFAVMAALVLPHVDLAHLHQHATWAGWTTALVLVVSAGGLGWTENGNDFSRYLPRSTPKHRTFLAAALGGAIPSVLLELLGAAAYVVSPHITTVTGVPSAFAAWFFWPFMLLALPQLFAINSLDLYSSGVTLQALGLPVQRWGAVIIDTIVAGAVTAVVVFQGRFYNDLSGFLDYIVAWVGPWFAIVLVDWLLRRRRYDRAALVAESGGVYWRNGGINWRAVAALLAGMTAALLWTDAQYYVPSYMSPISAATGGSDLSWLMGILVGGSAYALLSAGSIRREIDLVGAGAVGSGTAVLDGGVRQPRRPGRSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR2</accession>
    <name>A0A7K0JTR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000431">
        <property type="protein sequence ID" value="MST32919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="814" mass="86200" checksum="0F43BFFC95D88FE1" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU6</accession>
    <name>A0A7K0JTU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000567">
        <property type="protein sequence ID" value="MST33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="410" mass="45372" checksum="A1A8E6FB8E4B201F" modified="2021-04-07" version="1">MTVEQGAAAQDVVTITRLAEAKEIYRQREMRQALYDTGEVVMSGVLVNLHGDQHRARRRLENRLFRRETFLHYEQDLFPPVLEETLAPHVAAGRAELVSLSHELMMNLAAINAGVDRRERTEEETHRLYGYMMKFIEAATAKHHVGDWAEASGAVQTALEAFDAEFLLPSIDRRRAALAEVEAGRREEADLPQDVLTILVRNQDQLDLPHELVRREIAFFLLAGAHTSATAFTRTIDNMLTWFERHPADRARAIEDRAWVQRCVHETVRLAPSSPVGMRRALADVELRDGTVVPAGTEVVIDLVAINTDPEVFGPDAVSFNPDRQLPEDVPLHGLSFGHGAHACIGQELAAGVLTGAGDGTAALQWGLATVAVEAAFARGVDRDPARAPEVDRRTARPYWSSYPVCFGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW1</accession>
    <name>A0A7K0JTW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="27471" checksum="DA4CF8A79792C5B5" modified="2021-04-07" version="1">MSDRPADVVSPTTDQVLATKVSLADARAAGRVGYDKPTPQNSVMLLVDHQIGLMVGVRDFPSLATYKANVVALAQMAKALEIPVLISSSNAQWQNGDTMPELKDIFSDQPIYRRTGIINCYEDPTFRSAFDDLLGSTGRTHVIIAGVTIGTCCALPTLSMRNDGYQVFPVVDACGAWDDYEAQAAIARMSWAGAEPVTVFALGCELQADWKLPSGNDMLPPFTSQLPEYGWVVQNFWNNANQHAVPDPFGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW6</accession>
    <name>A0A7K0JTW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein GHK86_11740</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rapZ</name>
        <name evidence="2" type="ORF">GHK86_11740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000577">
        <property type="protein sequence ID" value="MST33386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="31673" checksum="DE049CCDA1CAC7AB" modified="2021-04-07" version="1">MVDYLIITGLSGAGRSQAAATLEDLGWFVIDNMPTALIAKVAELTSGPGARTQRVALVVGRDATQLEELQSAVRQLRLEGARVRVLYLEASDEVLVRRFEGTRRRHPVGREGVTDAIRIERERLRPIRELADIVVDTSETNVNQLRERLVELFADTAAQTMRVTVLSFGFKHGVPRDVDTLFDARFLPNPYWIDELRPFTGLDRPVRDWVLEQPPAEEFLDRVDDLLGFLLPAYVKEAKAYLTIAVGCTGGRHRSVALVEALAARIRARGYEPAVHHRDVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU79</accession>
    <name>A0A7K0JU79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000474">
        <property type="protein sequence ID" value="MST33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="319"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="706" mass="76751" checksum="1804C9E2EBB82CC9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD5</accession>
    <name>A0A7K0JUD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">GHK86_12645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000638">
        <property type="protein sequence ID" value="MST33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="346" mass="36382" checksum="1AB6A4B2A77D2A6D" modified="2021-04-07" version="1">MSALLVAGAVGLLSTMLGTPLLIGSLRIRGIGQHVREDGPSGHLQKAGTPTMGGITIIGGGCLGYLLAHAGRLEIFTARGIVAVVTICLAAFVGFVDDYLKVSRRRSLGLNARGKAAALLVIGVGFAVVAIKVLGVSTRLSFVRFDSPGWQLGAIGWAVLAVLAILGTTNAVNLTDGLDGLAAGSSGFAFMGFTVIGWFQLRHIEVYHNPYPASLDEAVLAAAFIGACAGFLWWNAAPARIFMGDTGSLGLGAAIAVLALLENVDLLLPIVGGLFVLEALSVILQVGSFRLFHRRVFRMAPIHHHFELLGWPETTVIIRFWILAAAFTSLAVGAFYADYLAHGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH0</accession>
    <name>A0A7K0JUH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000656">
        <property type="protein sequence ID" value="MST33597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="434"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="528" mass="55714" checksum="B3ABA1A39AB2524B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH5</accession>
    <name>A0A7K0JUH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000658">
        <property type="protein sequence ID" value="MST33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="27"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="277" mass="29245" checksum="00C14C4D27C6671F" modified="2021-04-07" version="1">MSEPESSSFTDPGGVTVHLYRWVPAGPPRALVHLAHGMGEHARRYDRVAAALTAAGYEVWADDHRASGRTGAEGAGLGDLGPGGMQGAVESLHAAVAHVAATRPDLAVHLVGHSWGSFLAQRIAERWGGDLAGLVLSGSTLLAGEYLTLGDPNERFQPAATPYDWLSRDPAEVRAYLDDPWCGFEVAFDVAELVHLAIPPADSIPPGLPILVVNGSEDSVGGFNGGGAALADAYRELGVVDVTYREYPGARHELFNETNRDEVLADLVAWLDAHTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL2</accession>
    <name>A0A7K0JUL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_13070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000671">
        <property type="protein sequence ID" value="MST33645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="164"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="312"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="405" mass="45223" checksum="8B0E9D3E9DC78764" modified="2021-04-07" version="1">SLERLAKLDEELANLREESAALTARWQNEKDAITRITALQEELEAKRNEVDRYERDGDLGRASEIRYGQLPALERQVAEAAGRLAELQHDSKMLKQEVDEEDVAEVVSKWTGVPVTRLLEGELAKLVRMEDVLHQRVVGQDEAVRAVANAIRRSRSGLSDPDRPIGSFLFLGPTGVGKTELARTLADFLFDDPRSMVRIDMSEYMEKHTVSRLVGAPPGYVGYDEGGQLTEAVRRRPYAVVLLDEIEKAHPDVFNVLLQVLDDGRLTDGQGRTVNFTNTVLIMTSNYQGDLGAAFKPEFLNRIDEIVRFRALTEDDMAAVVDIQLRALEERLAARRLALEVTPEARAWLARRGYDPAFGARPLKRLIQRQVGDRLAIALLEAKYAEGATVVVDAPAGDDGDLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW6</accession>
    <name>A0A7K0JUW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_13655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000713">
        <property type="protein sequence ID" value="MST33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="93"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="430" mass="44220" checksum="07FE938ACA60B90D" modified="2021-04-07" version="1">MSRRGNHRRSSAWSSSRKSDRGIGFYLLVLSLVVLVLVVAAGAYVGIQLNRSVPKATASVVFHDPLTAAGTRPSLPVPAQGSTDVAVEGVGTLAAVNANKSVPVASITKLITALVVLQHHPLQVGQQGPEITVPAAIGSAYPAELAAHDSLIPVHTGEHLSEYQCLEALLIPSADNVANLLATWTAGSVSAFVAEMNAKATALGLHHTHFADASGLSPGSESSAADLVHLGEMVLNQPVIAQIVAMPQVNLPLAGLVYNYDYDLGRDGIVGIKTGSTLPAGGDFLFAAHHKVGGRTLTVVGAVLNQQGKNILQAALDAAKRLAVAAFADIHPVTLLRAGVPVVRVTAPWGGSTQAVTTRTVTTLGFSGERVQAAVHLAGPATTRALKSPVAAGAELATVQVTLPDGTVSVPATTVGSIKAPSLSWRLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX5</accession>
    <name>A0A7K0JUX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000716">
        <property type="protein sequence ID" value="MST33767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="79" mass="7772" checksum="B4CF54B8EAD1B8E1" modified="2021-04-07" version="1">MTGPADHVELFGEAPTRVLLSVPPAAVAAVREAVDGAGLEVVELGDAGGDRLVVGELVDVTVADLDAAGRDVLPGALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX7</accession>
    <name>A0A7K0JUX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000703">
        <property type="protein sequence ID" value="MST33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="32064" checksum="FE35693DF2B9B349" modified="2021-04-07" version="1">MSGPGRPRRERKAWGLRGFTWLYLVWSLVPVAIAVLFSFNRGRSQATQQGLSLRWYIGKPSSNGVYTSVLHSAALHSALLQTLRLGALTTLICVPLGLAFALGIDRWRSRTSNGLNVVMVFSFVVPELLLAVALAFFFQKLFTPVHLGTWAETLALVVWNLSWPAIIIRARLVSIGYAYEEAASDLGAPRWSAIGRVLLPLLWPAIFASAVLVFASVIDDFVIVEQLSSTAATQPAAVLIYSQQHGGSGGPALNALATLMLLMSLVIAVVGYVLYRLMTRGERGSGIQAIESIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY6</accession>
    <name>A0A7K0JUY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14914" checksum="D4733AFDB769FCBE" modified="2021-04-07" version="1">MAVCALRAAASPERVRRVLADGHRYADRVIGARSVRAVEGDWPRRGAQVHHEVDLGPLRVRDFTEGVDVAPGSIPVLGAHVGPLGVARVRVDLVPSGAGSLVTLSEEPLGVPVVVRLVLELPVFVRNARSLRRLASLASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV31</accession>
    <name>A0A7K0JV31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000731">
        <property type="protein sequence ID" value="MST33798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029450263" evidence="1">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="224" mass="21979" checksum="9E24E792217E9D50" modified="2021-04-07" version="1">MTVLASSPVLVMAPAAMAAGAPHKPGHGLAGARRGAEAVLKQDVRRLAAVSSHEQASKVINATDKAALLAAVGTSTTSGQAYAIAQDQAAVAAATSLGQIRAAVVSGRTTLSAAYLDWHVVVAADRIEARAAALDTRGAALLTKAQAAGNTSAEATLADLTTETTAADTAAQAAVSGVLGLASTAKPSDVRAARASAGKDLVTARKALAAAMHDAARAAGELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN9</accession>
    <name>A0A7K0JVN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FtsW/RodA/SpoVE family cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_14940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000810">
        <property type="protein sequence ID" value="MST34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="471" mass="49269" checksum="5C04342F4207FC89" modified="2021-04-07" version="1">AVTTVGRPATDTHAEHGVAVAALPGRRPARRRTELGLIVLAVILTGGLYALAGAGRAGSLPANIGPFLGVIFVLLLIGHVAMRFLAPEADPILLPVAGLLNGIGYVFIARLSSAEASAQALWSTIGMAAFVVTLLVVRRARDLARYRYTWGALGLILLLLPLVPHLGENINGARLWIHVGSHEFQPGELAKLALAIFFAAALVERAEQLSRGTRRVGRMLVIDPKHLAPVVGAWGLSLLIFLAENDLGSSFLFFALFIGMLWVATNRAIYLGLGAGLFAGGAAFALTAIGHAKTRIQSWLHPFAHPTTTGYQILQSLFAIANGGVFGTGPGQSNAAIIPEASSDMIFAVVAEEIGLVGAAALLVAYLLMVGTGLRIAIRCENAFEKLLATGLALIIGVQTFVIVGGVTNLIPLTGITLPFVSYGGSSLISNYILLALLLRISDTAARQGLPTAPSRRRGSGSEVRLAEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR3</accession>
    <name>A0A7K0JVR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000820">
        <property type="protein sequence ID" value="MST34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8386" checksum="DA4BE6817E4F72E3" modified="2021-04-07" version="1" fragment="single">MSATPATATAEHPRADVGGVPVSVDHYIGGRRVASATTFEDRSPLDWNWKLADVSRGDASTAALAVDAALDAAPGWAALGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX9</accession>
    <name>A0A7K0JVX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000850">
        <property type="protein sequence ID" value="MST34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="12924" checksum="D97F4A43F39D2D63" modified="2021-04-07" version="1">MAHSVDKAGKPVVTYSLREVLAGTRAEQDRGFAEVHAALAGKADRREFDVLEAVLGRVEDRLSRLEGWQREQRTAAVEHEKDATRDQQRRNWRLAVVGVCVPLLVGLATALPVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW31</accession>
    <name>A0A7K0JW31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BldC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000716">
        <property type="protein sequence ID" value="MST33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7431" checksum="6442901BD1B61C16" modified="2021-04-07" version="1">MAEQPQVDTLLTPAEVAALFRVNPKTVTRWARAGKITAIRTLGGHRRFRASEIRRCLEQLETGELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW55</accession>
    <name>A0A7K0JW55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000856">
        <property type="protein sequence ID" value="MST34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="283" mass="28693" checksum="9B3EEC48C6E8AAF3" modified="2021-04-07" version="1" fragment="single">RAHDDALGDRAWAYRNFRILLLGQAVSSLGNTLVPVCLAFAVLALTHRASDLGAVLGCEAGAIVVFLLPAGVLADRWSRRATMVASDALRGVSQAALGLLFVTGHPPLGLVAALAAASGAGIALYYPAVSGLVPSLVGPGALQRANALQQTVVAAAGVAGPALAGVLVVGVGAGWGLVVDAGTFGVSILTLVTLRLEAAPGAGSGRFAADLWEGWADFWSRAWFRDVVIGASVYNFLYAGYTVLGPVVSERHYGGAAAWAAAATVTGVGSVVSAPLVARMRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW62</accession>
    <name>A0A7K0JW62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000892">
        <property type="protein sequence ID" value="MST34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="145" mass="15088" checksum="04603337AEBBF269" modified="2021-04-07" version="1">MTISVVLDAAAFDVIDTAEGAQLRQLLRAVLGRGGTARCAAVTLAEVCRGPARTRRVEVALARDRGGQRILVAPTDEALAKLVGAVLHALGRSSEAMADAHVVAVCARTDASIVITSDPDDINELATALPGTRITTRTPRAIAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH2</accession>
    <name>A0A7K0JWH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000765">
        <property type="protein sequence ID" value="MST33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="70"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="35135" checksum="E4FB0255D251EAF8" modified="2021-04-07" version="1">MGGRRLRPRRAGRPGRQPAARGHVAPELSGDRAPGAVARRLFVIRSGGERTLRGLFDPWDPRAGETVEIPYYCYAIDHEAGWVLVDCGIHPALLEDPVARLGPQAAMSELVAAPGDDIASQLAGIGVRADQVVHVVLTHLHYDHCGGLCLLPAAEVHVQAVERAFAEAPPVYQAPAYQPDDWATVGRWREATGEVDLFGDGAVVAFPTPGHTPGHQSVHVRLAGGDVLVVGDAAYHPAKMRERRLPAYLWNPDAVVATWEALERRRDRSGATLLFSHYPAPDRLVLAPQAWHPPADTSGNEDEGEACGRPSCSPRSSRWRSSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ0</accession>
    <name>A0A7K0JWJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000942">
        <property type="protein sequence ID" value="MST34316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="27498" checksum="708717914A880070" modified="2021-04-07" version="1">MLDRSSPLPLWAQVADDLRRRLAAGELDAHFPTDDELTLEFGVSRQTAREAVRHLVAEGLVVRERGRGTTVAPTVLEQPLHSLYSLASTLRASGLAERSEVLASHRLAATEEVAARFGAAKGTELVYVERLRFAGTEPISWDRSWMPAEHAARLLEADLSSGSLYELLASYGVRVTGGWERIRPVVPDPRARKLLQLPARTAVFSIERLALAGETPVEWRTSLVRGDRYSLVAQWPAHAQPPAADRAGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR3</accession>
    <name>A0A7K0JWR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_16875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000977">
        <property type="protein sequence ID" value="MST34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="42"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="10">
        <location>
            <begin position="254"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="11">
        <location>
            <begin position="568"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="734" mass="79489" checksum="A03BB315F013365D" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS2</accession>
    <name>A0A7K0JWS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000980">
        <property type="protein sequence ID" value="MST34393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="184"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="324"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="581" mass="62698" checksum="5928E782A6A6F95F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX17</accession>
    <name>A0A7K0JX17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001033">
        <property type="protein sequence ID" value="MST34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="29947" checksum="7B4F733BAB02F31F" modified="2021-04-07" version="1">MKLATVHTPSGTAAVRLEADDAVHLGASDVGALLGDPEWRERAASAAGERFAVEGLDYAPLVPHPEKIVCVGLNYRNHIEEMGRELPTHPTLFAKYPPALIGARDDIVLPRVSEQMDWEAELAIVIGSPVRAADERAARAAIAGYTILDDVTARDWQNRTLQWLQGKSFEASTPLGPALVTADEVDAEAGLRISASVNGEVVQDDTTGQLLFGPVELVRYISTFVTLRPGDVIATGTPGGVGHGRTPPRYLQDGDVLVTAIEGLGECRNACRREANGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX30</accession>
    <name>A0A7K0JX30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_15465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000857">
        <property type="protein sequence ID" value="MST34114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="26648" checksum="1642681E03D39E07" modified="2021-04-07" version="1">MTAGAASTRVLLVEDDPNIVDLIRANLSVRGFDTVVSRDGARALPLFETERPDIVLLDLMLPEVDGFDLCRSIRERSPVGIIVVSARGGERDKVTALNMGADDYMTKPFSIEELLARIAATLRRTRPAPPETAPSDLLRLGPLQVDLAGQQVLREGREVHLTPTEFALLRELATNRGKVLSHAHLLRRVWGPGYETETEYVRVYVRRLRAKLEADGDAPLIVTQPRAGYRLEPEPPGDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD8</accession>
    <name>A0A7K0JXD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="8">6.3.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purD</name>
        <name evidence="8" type="ORF">GHK86_18055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001104">
        <property type="protein sequence ID" value="MST34618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="289" mass="28988" checksum="F29A7D2F9572179E" modified="2021-04-07" version="1" fragment="single">PTAAYATFAGPDEADAAVRYLRSLPPPWVVKTDGLAAGKGVLVTTDRAAAEADVRAKLAGTAFGDAGRRVVIEEGLTGVELSVLAVCDGRRAVPLAPARDHKRVGDGDTGANTGGMGAFSPVPGAGDAVVAEIMDRCVTPTLDALRQRGIDYRGVLYAGLMLTPAGPRVVEFNVRFGDPETQVVLARFEGELAALLAAAARGDLESAGPPRFAPGAAVHVVLAAGGYPEAPRTGDPLDPTRLASAAGLPGVGVIAAGVAAGEGGSLRTAGGRVLGVTGTGPTLAAARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE7</accession>
    <name>A0A7K0JXE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ORF">GHK86_18140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001118">
        <property type="protein sequence ID" value="MST34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8565" checksum="9359CDDA272AC053" modified="2021-04-07" version="1">MAVDYTKAIEMAGAFTGGGLALGGGAIGAAVGDGLAGSSTIAGIARQPEVQGRLYTTMFLIIGLVEGMYFINLAFMALFVFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF1</accession>
    <name>A0A7K0JXF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_18130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001118">
        <property type="protein sequence ID" value="MST34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="2" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12180" checksum="590E041192B84D30" modified="2021-04-07" version="1" fragment="single">MRERIRGYADALLEDAVASGRIGAVADGVAGVAALLAASDELRDVLTDPGVASHTRRAVVQDLFGGRIDADAVRLVQHVIDSDRAPDLPDDVAWIATRSAAIRDHRREIGITTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ6</accession>
    <name>A0A7K0JXJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_18355</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="WJHE01001144">
        <property type="protein sequence ID" value="MST34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20922" checksum="132354AF5DDDE898" modified="2021-04-07" version="1" fragment="single">MPILRPLRARPRKADAPTLSIERSLWEAGRQVVVGVDEVGRGAWAGPLVVGAAVVPRDRRVYGVRDSKLLTEVQRERLFDRVAAWCAPWAVGAATHEECDELGMAEAQRVAARRAIEGLGVIPDAVLVDGTWDFVGLGTTQRVVRGDAACLSIAAASILAKVSRDRRMREEARHFPGYDFDGNKGYPCPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN9</accession>
    <name>A0A7K0JXN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000930">
        <property type="protein sequence ID" value="MST34289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="10183" checksum="DBACDD057149E800" modified="2021-04-07" version="1" fragment="single">MERRERPRRSTAAVAAVLSFGLLFWLWTLLVGAIDLEDVLAGLVTAAVATGVGWLATRQGRAIPRFAARDLVELARMAPLVFTETAEVYAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT2</accession>
    <name>A0A7K0JXT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001207">
        <property type="protein sequence ID" value="MST34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="60" mass="6541" checksum="83F41740580ED6C9" modified="2021-04-07" version="1" fragment="single">MDRPPPDPQKLLDAWMEWERGETPPGRVMSQLKTGGLRDLLEAMVADLPAAVVATGAPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW5</accession>
    <name>A0A7K0JXW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001219">
        <property type="protein sequence ID" value="MST34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="18235" checksum="5DE553BCBD2636F4" modified="2021-04-07" version="1">MPFDVGDKVVYPHHGAAVVERREVIEAFGEKKEYLVLRLAYGDLILRVPTDNTEEVGLREVINDEEVEEVFAVLRKKDVRMPTNWSRRYKNHVEKLKSGDIYQVAEVVRNLSNRDKDKGLSAGEKRMLNRARQILVSELTFALGVDEVDAEKKLDEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX2</accession>
    <name>A0A7K0JXX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000967">
        <property type="protein sequence ID" value="MST34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="27254" checksum="8D6703B3F62FBAA9" modified="2021-04-07" version="1" fragment="single">MAWSSSTAPASRAKLCGVSKGLEVRDLGHRFGELLAVDGVDLDVGPGEIVGLVGRNGAGKTTTMRALMGILLPDRGELRWEGRPLEPADRLRFGYMPEERGLYPQMRLADQVGYFARLHGLPAAEARARTASWLTRLGLAARRDERVVALSHGNQQRAQLAVAVVHDPDLLVLDEPFSGLDPEAVLALSGELRAIADRAAAVLLSSHQLDLVERLCDRVVVLEGGRVLASGSLADLRAEVPARLRVRVAGRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY32</accession>
    <name>A0A7K0JY32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001003">
        <property type="protein sequence ID" value="MST34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="261" mass="29050" checksum="449AED43015D6DCF" modified="2021-04-07" version="1">RLGKPVLVEGPAGTGKTQLAKSVADMTGARLIRLQCYEGLDEAKALYEWNYKKQLLRIQAQRLGEDAGASSWTDIEEDIFSEPFLLTRPLLEAIRADDPVVLLIDEVDRVEVETEALLLEILSDYQVSIPELGTVAARQIPLVFLTSNNTRELSEALKRRCLFLHIDYPDLEREKEIVQVRVPGIADDLAEQIVRIVRSIRALDLKKAPSVSETLDWARTLLLLGISHVDAEAATGTLHVLLKYQSDIEKATKDLAASAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY50</accession>
    <name>A0A7K0JY50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001282">
        <property type="protein sequence ID" value="MST34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25130" checksum="0EFCD1AD28EC01A2" modified="2021-04-07" version="1" fragment="single">MVWVVLVGLASLAPALAHGSKLGAFGVVHSYGIEATPGQRGPYNPVASDQVQQTAPWVALDWTEVHHGHLPLWNPYSAMGTPLLFDFQSAGLSVPALVSYAFPWRFSYDVFVFVKLVIAGTGLLFAARVLRVGWLGAALGASVGELSGAFSGWLGWPMDGVLCWTGWVLGAGLLLARGRRRRLAVPLLAFSLAAAVYGGHPESLVILAVAATVPVVVALVAGARSGGGRALLGRLATLVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY60</accession>
    <name>A0A7K0JY60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001285">
        <property type="protein sequence ID" value="MST34898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="12433" checksum="6218DF5D0FC4F951" modified="2021-04-07" version="1">MSDLPISDLTTSTIYQALQGLTAQQNAISQNVANLDTPGYTAQNVSFQQSLASAVAQGNPSAMQMTLVPSAAPRNQAGNNVNLATETVDAEKTSLAYQTMVQAMNAKMQLLSTAVTGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY61</accession>
    <name>A0A7K0JY61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001017">
        <property type="protein sequence ID" value="MST34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="32058" checksum="16C68445D091E19C" modified="2021-04-07" version="1">MTTPIDEIPSRFTRRRLIQAGVVTGGALWAAPAIESFTSPAAASSKPRSCDLGVDWCYVAYRNQGDAEGVYHYTGFMGRTNTDCGCLASNDYPSTTVQNRPWGNFQLCSGDKPALKYWRQDGSRYDPQYVDSPDDGGCSFTLESDTTTCKIKAGSDKEILGAFYPSSNTCLGIPPFGSGTGNHVEVPLPEDLSGGGPPGATTPSPPPPKCSIGGAGNHETNTPAAGAEQGLLVAAVGHPARTSAAVSVDTPVIALPGTRITRAEPRDAPGSQPPPATVIHAGSPSQPRVRRANPPPSGRATAQLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY75</accession>
    <name>A0A7K0JY75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001297">
        <property type="protein sequence ID" value="MST34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="260" mass="28360" checksum="6DACCC185FCC8702" modified="2021-04-07" version="1">APAAGARGGGHPPQPQVQQGERRCGEEEDLQHRVLGGRGRPPGPAPRPLRRQRRPEPERRRPPLQARRHLRDQRLEQGSRAGVRLHQHQELEGRVLHHPRGLVSGPGHLADQARAWLDRRGWAWEEEADGDGLVLAVGDRPSGERWRWYLQVREPQHQVALFAILDDDVPPERRSPMAELVLRASFGLTVGGFELDLDDGQLRYRTGVGLGPVAAGGLDLGALLDEMAGVNQAMTGVYGPAITAVLAGEEPAAAVQAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE7</accession>
    <name>A0A7K0JYE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001335">
        <property type="protein sequence ID" value="MST34976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="17412" checksum="2D62463523768B20" modified="2021-04-07" version="1">PDATADRRVFAARCGVRERERQLGTGYGFGVFVDGRFAGEINLSSVQRGPYQNAYVGYWIDEAMAGHGYTPEAFVVVARFAFEDLALHRLQASIIPRNSASRRVAEKLGLRNEGVAVRYLEINGVWEDHVRYAITSEEWEQRAEAYRRDWLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF1</accession>
    <name>A0A7K0JYF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001338">
        <property type="protein sequence ID" value="MST34980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="16495" checksum="7BD83AD5EBEBFC8A" modified="2021-04-07" version="1" fragment="single">MPVDLTVDGRARTVQRDGVSLLEALRDELGVRSPKDGCSPQGQCGCCTVLVDGQPRVACVTAVRRVAGRSIVTADGLAPEVVEPLAHAVLAAGGSQCGFCTPGILCRLAALGPRPEPAAVDRALLAHLCRCTGWQGIRETTASVSRTSATTTSTAPATSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF6</accession>
    <name>A0A7K0JYF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001332">
        <property type="protein sequence ID" value="MST34967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="9138" checksum="8D966C917A816B93" modified="2021-04-07" version="1" fragment="single">MTPPREGRAAQRHLAEVGRGSHNGGVATRGRVSLYEAAEELGVHYQTAYRWVRRGVLPAVKVNGSYEVAVAAIDELRRDRQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ0</accession>
    <name>A0A7K0JYJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001371">
        <property type="protein sequence ID" value="MST35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="515" mass="53751" checksum="31617CB3B040B2E0" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ4</accession>
    <name>A0A7K0JYJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001365">
        <property type="protein sequence ID" value="MST35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="23643" checksum="33ABC33EB272884D" modified="2021-04-07" version="1">MTSRVLVTGGASGIGAATSAALEAGGWEVLRADLAETEGVIPLDVTDEAGWDRVLDSCWPLTGLVNCAGIRLRSPLADTDLGDFERTLAIHVRGVFLALRGIARRTADDERSPMGVVNIASTVSSHAVAGQVAYVAAKGAVAAMTRAAAVELAPRRIRVNAVVPGLIRTPMTADRFEDPGQLGWFAARTPLGRAGEADEVAPVVAFLLSPASSYMTGAVVAVDGGYTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV6</accession>
    <name>A0A7K0JYV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001451">
        <property type="protein sequence ID" value="MST35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="33" mass="3451" checksum="D37F5216EE7BB96F" modified="2021-04-07" version="1" fragment="single">MRSVVVTGVAGSLGRRVARLLAGRDDVDRVIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ06</accession>
    <name>A0A7K0JZ06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001496">
        <property type="protein sequence ID" value="MST35180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11413" checksum="8F7BBEB75425DFA7" modified="2021-04-07" version="1" fragment="single">MALWYSVEVFDGATSALGWAEAWTDSLIGAALGCGASDWTWHSHPWGVVLEVAFGDEAAWEAFRANPTVAAALDAVPDPLTGLIVYRGRGGSAGATSPRRPRPLVGSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ09</accession>
    <name>A0A7K0JZ09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TraM recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001491">
        <property type="protein sequence ID" value="MST35176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="24150" checksum="F993B9BCB543793B" modified="2021-04-07" version="1">APFGDPLVARATARVDVSPEDLLAGRHSLYLCGPAHEQLRVQGVFAALVASVVAAAVRRTADTGRPLDPPLLLVLDEVANIAPIRDLDGLASTAAGLGIQLLTVCQDLAQLAGRYGPDRSRTIANNHRAKLVLSGVADLATLDLLSGLAGEQAVREESLTTDLRDGRRTRASTVAYRRLAPPDELRRIRPGEGVLVYGHLPAARLALRPWYRDRALRRRVGPSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ58</accession>
    <name>A0A7K0JZ58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001254">
        <property type="protein sequence ID" value="MST34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="22094" checksum="C333BEBF9793A884" modified="2021-04-07" version="1" fragment="single">MSVAFQTDKPPGAYARLAATAEALGFDGVSTFHDLGYQPSLPALLEMAAATTRVRLGAAGLNPTLTHPYEIAGQVAALDAASHGRAYLGLVRGAWLDRVGAADADRPLQRLEEAVAVVRRLLAGDDRGYDGRTYRLAPGFRLAYRRQRAGVDVLLGTWGPKGTALAGRVAEELKLGGSANPDLVRLVRARLDAAAASAGRGPAAVGLVAGAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ85</accession>
    <name>A0A7K0JZ85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001584">
        <property type="protein sequence ID" value="MST35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="21084" checksum="223C2759D1C691A2" modified="2021-04-07" version="1">RDARDRRPGGGRHPHRAGARLLHWALRSVLGGHVKQQGSLVAPERLRFDFTHYSPMTDEEIARVEDLVNAQILLDEDVVVTEMTKAEADAAGAIAFFDEKYGERVRVLHAGSQSVELCGGTHVDRLGQIGPVEIVSESSIGSNLRRVEATTGTATLERLRRAEGRLRDTAELLRTTPEAWSRTASIPSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ98</accession>
    <name>A0A7K0JZ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001531">
        <property type="protein sequence ID" value="MST35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="20362" checksum="1DCE67E55058C315" modified="2021-04-07" version="1" fragment="single">MGTEPTTQHPPAPDGAGPLVAEVDVLVVGAGLSGIGAACHLRREVPGRSVLVLEARDAIGGTWDLFRYPGVRSDSDINTLSYSFRRWRGDAVIADGATILDYIRTTAAEHGVDRLVRFGRRVLAACWSSADARWEVEVERAGGGRERYRSRFLYLNTGYFRYDRGHTPELPGLDRFAGPVVHPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZL4</accession>
    <name>A0A7K0JZL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001361">
        <property type="protein sequence ID" value="MST35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="155"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="335" mass="34758" checksum="287BE65E1FF8BCDC" modified="2021-04-07" version="1">MDGMRVAIVGAGWMAEQHVDELRRRDDVDIVGVADVDVDRARALAGGGEAFASWEELLGAVTADALWVCTPPATHADIACGAFDRGMAVYLEKPIARDVADGRRIAAAAEATGAVCAVGYQWHAVELLPRVREALAGRPVGFVLGKNIGATKVRPWFVRQEQGGGNILERASHHIDLVRLLAGEVDAVQVGTSSVSLGGRPRDTGDIEDALTVVLHLRSGGMATVLVVWLREGLPTSYGLEIAADGAYLRLDLDPAFTLDGVVDGSPVHAVAGAPALRSSIDRFLAAARAGDPSLVPCTPADALRTLAVARAAEAALVSGGTVLVGEDDGGSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZN5</accession>
    <name>A0A7K0JZN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001376">
        <property type="protein sequence ID" value="MST35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15563" checksum="79D5164E5B648C30" modified="2021-04-07" version="1">MPTFPTLRSVVLDTTDARRLAEFYRRLLGYRYRPGDEPPGPGSPDRRGADWLVLVAPDGCGRLAFQRVDRLDAPTWPDPAGPQQLHLDLAVATTAELASQHRRILALGARLLEDRSDDPDEPLYVYADPAGHPFCVFVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZT7</accession>
    <name>A0A7K0JZT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">nucS</name>
        <name evidence="3" type="ORF">GHK86_20455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001420">
        <property type="protein sequence ID" value="MST35089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="24068" checksum="04D481578AFDF217" modified="2021-04-07" version="1">MRLVIATCTVDYAGRLAAHLPRAKRLLLVKADGSISIHADGGAYKPLNWMSPPCTLRMEEGRWVVTNAKGETLTIELHEVHGELSHELGPDPGLQKDGVEAHLQELLAANPHVLEPGLALLRREHPTDIGPVDLLCRDAEGRTVAVEIKRRGEIDGVEQLARYLERLELDGRLRPVRGILAAQLVKPQARTLAAARGIAWVEVDYDELRGVGTGRLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMH8</accession>
    <name>A0A7K0JMH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_00210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000008">
        <property type="protein sequence ID" value="MST31153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="117"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="292" mass="29757" checksum="E905370EA21A0D4E" modified="2021-04-07" version="1" fragment="single">MGDGRLGVAEPLRRPPERAGVGHRHQGPQLPQADPPVEGPGGDVLVVGGGSNGNDRSSRSLWPDPFHKHRIRVPVCFILQGLNEENLHVRTDLAREDGPAATRPGSGPRSRRPAGGVSALVYALIFVTAVSQATIVPLLPTVAHRYGLRASELAWVLTLPSLAMLVTSTPIGLLGDRLGNRRVTLAGGGLLAVAALAQGVPSLPVLVLGRLLFGVGYGALWTTGLAWLAGLDPGTSARRLGGTVTASAVGATVGPTLAGVLASRYGFAVPFLVAGAVTAVVAAALVGLRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMN7</accession>
    <name>A0A7K0JMN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">secA</name>
        <name evidence="19" type="ORF">GHK86_00575</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="WJHE01000021">
        <property type="protein sequence ID" value="MST31226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="18">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="87"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="415"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MST31226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="926" mass="103221" checksum="D184D7EE4183690B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMQ3</accession>
    <name>A0A7K0JMQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000025">
        <property type="protein sequence ID" value="MST31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10508" checksum="42836284E0F88FDC" modified="2021-04-07" version="1">MVTLTEEGAHTFRAEVRDARGQTTHTVEVPPGLAAELGWAGASEADLVRASLAFLLEREPPTSILRRFGLEVIATYFPEYPGEMRRRAPTTPPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN11</accession>
    <name>A0A7K0JN11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="4">
        <location>
            <begin position="6"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="321" mass="33008" checksum="6A139427A0758821" modified="2021-04-07" version="1">MPVETIWVVVDRQGERIAPLSLELLTKAKDLAARVEGVTWGDADQLAGEAGAFGADVLHTVGDLGGGLPGPAVAAAMAARIDAGEVPDAVFAPHNYDGRDVAARLSAKIDRPVLTNVVGLIDAEGLRSEHPIFGGTEILTARFSGEGPGIFVVRTKSFAAEESGGGPAAVDAWEVPELGATGAARIVQRHVEEREGPKLDEAAVVVSGGRGLGAADGYQMIEALAKLLHGAAGASRAIVDAGWVPYSHQVGQTGKTVKPTVYIAAGISGATQHMVGMKGSKNIVAINKDQEAPIFSIADLGVVGDVNKVLPKLIESLQARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN26</accession>
    <name>A0A7K0JN26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000047">
        <property type="protein sequence ID" value="MST31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="7952" checksum="DCB649A884CB0A0C" modified="2021-04-07" version="1" fragment="single">MAEPGIVVVGGGECGARAAFALRQRGWTGPVTIVGREALPAYERPPLSKAALAGDGWAPAHPWAEADYRAAGIGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN32</accession>
    <name>A0A7K0JN32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WhiB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_00755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST31261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8865" checksum="C57A8998721A8B73" modified="2021-04-07" version="1">MAVRDDSWYRLAACRGMATGLFFPESGRPDPAVVAEAKAVCAHCPVRERCLAVGLREEHGIWGGLTVGERRTARRAQPGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN62</accession>
    <name>A0A7K0JN62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000040">
        <property type="protein sequence ID" value="MST31343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029724767" evidence="3">
        <location>
            <begin position="25"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="42484" checksum="D7806B2A29C01CA1" modified="2021-04-07" version="1">MWVYVAAFVAALLFALGSVVQQRAASTAPPEKALSFALLLWLVRRRVWLLGFVASVVGNGLAAAAIGGGGVALVQPLFTSRLLFALALSAVLSRITVGRRDWIAALLTAGGLAAFVAVGQPGKGHPLDATTLQWSPAVAGVAVLVAALVTFSKRREVAGASLALAAAGGLLFGLQSSLTETSIAYLQRDGFGTFAHWQPWILIAAALYGAVLVQSAYEMAPLPASFPALVSVEPLTGLVLGVTVLHGTLDTSAGALVAEIAGLGAMVAGVALLARSPLVTGQLAALERRREEGIAYRTARELEELLGDTEASVGRAHASPVGRAGDGERGRHLRDADRQLERLGALLEAMDRHRVEEAEQLRRLPPKQRYTLAPLEQELDERQARIEAWAERLRWERSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE4</accession>
    <name>A0A7K0JNE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Excinuclease ABC subunit UvrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">uvrC</name>
        <name evidence="9" type="ORF">GHK86_01900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000079">
        <property type="protein sequence ID" value="MST31486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="7">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="6">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="8">
        <location>
            <begin position="264"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="646" mass="73000" checksum="FCD746B28B2A1E34" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI6</accession>
    <name>A0A7K0JNI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZnF_CHCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_01515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000062">
        <property type="protein sequence ID" value="MST31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="7">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="693" mass="75269" checksum="CC4A359681A2BC0C" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN0</accession>
    <name>A0A7K0JNN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpsP</name>
        <name evidence="4" type="ORF">GHK86_02280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10788" checksum="98266F8F0808F4D5" modified="2021-04-07" version="1">MAVKLRLMRMGKKKQPIYRVVAADSRSPRDGRFIEILGTYEPQAEPSKVSIDNAKAIRWLRTGAQPTERVAKLLEQAGTIQEWKTGVPAAPAAEPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS9</accession>
    <name>A0A7K0JNS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flotillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_02650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="5">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="404" mass="42509" checksum="3313E7BA6744C2F7" modified="2021-04-07" version="1">MLGWHVPRPDEAMLISGGKRTGTPFKIIIGHGSFVLPLRSRVSYLTLSMQEAEVAEECVTKQGIAVNVKAVIAFKVGADPEGIANAAQRFLGSEDKMSVLTGRIFAGHLRSIIGSMTVEEIIRERQRLAEEALEASKLEMSKIGLVVDALQIESIDDMGSGYIKALAAPHVAEVQRAARVAQAQADQASAEAEQLSQRKQAEYERQTAIARAGFKAETDKAQATAAQAGPLAEAQATQDVLDAQTELAQRNASLRQEQLVAEVLRPAQAEAQKIKILADAEADRLRRLSEAGAANDRVALDQQLIAQLPEMLRAAADSLQNANLTVLGGSDGLGDLVSGLAAQGLNLFEALRGSVGQPDARRGDGNAAASRGPNGADLAALTGGNGGSVAGPPQPRPIEEGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT2</accession>
    <name>A0A7K0JNT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2469 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="11735" checksum="1021085FBF36171A" modified="2021-04-07" version="1">MSAEDLERYETEIELQLYQEYRAVLPMFRYVVETERRFYLANDVKMEAHGEGARTYFEIRLADAWVWDMYRPARFVSSVRVVTFKDVNVEELPEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT5</accession>
    <name>A0A7K0JNT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000099">
        <property type="protein sequence ID" value="MST31573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029829146" evidence="2">
        <location>
            <begin position="48"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="478" mass="49973" checksum="AA3E2096EB97201E" modified="2021-04-07" version="1">MQPPNPFSAPTPPTPRRRRRGTVTAGVLAAGVALALSGCGSTGNSNASTSGSGGLSSGSGSSGTATTAPKTSNNVATAKGNATSGNITWEASPINTSGPDVRQVLIKAFEKQYPNIHVTLQSAPTSTTTYQSQLMTQIAGGSGPDVFMGDVIWPAQFGARGLAVPISKYLPTSYFNTFAKGLIAGASYNGQVYGAPFFQDEGFLYYRKDLLAKDGLQPPKTWAQVQSDSKTMLAKHQVQYGYVFQAADYEGATCDFMEFLADEGGTVLTSNAKKASLGPAAVKALALEDSFVQKGLSPKNESTFEEANAMTAFQNGQAAFMRNWDYGYSTSQASGSKVIGKVGVEPMPSVSASNWPGYSNIGGWNLYINPHSKNVAADLTFIKWMTGQTAQTDLSTVASEIPTINVVRNSAKVKAINPVLAIVGETKLVARPSQTPKYAAVSQAIYQNVSQSVAGSESPSAAVKNMTSSINNALGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV7</accession>
    <name>A0A7K0JNV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046094">
        <property type="entry name" value="DUF6112"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19607">
        <property type="entry name" value="DUF6112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10113" checksum="1A5D302247DCB5D8" modified="2021-04-07" version="1">MNLPASATLPAGDLIAGVNVTPNTTGLPGITELQNIVGALLTLGLIGALAGLALSSIVWAVGNHSSNPVLAGRGKTGVLVAFVAAALTGGAVVLINFFAGAGAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP31</accession>
    <name>A0A7K0JP31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15893" checksum="9C37421F5D5106EC" modified="2021-04-07" version="1">MSDPIVVGGHTRIRPFNTRDTYPEQRLDNDLCQAVIAGNTVYVRGQIGQDLDTSESIGIGDVAAQAERAMANVALLLDEAGARMEHLVKLTIYLVDPRYREAVYRIVGRWTQGVHPISTGVVVSALARPEWLVEIDAIAVIADGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP50</accession>
    <name>A0A7K0JP50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FPG_CAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="14633" checksum="A748648F1439329A" modified="2021-04-07" version="1">MPELPEVERYRRLAEGAVGRRIRAVDAPDAWILKGGLDAAALAGALVGRHFTAARRRGKLLILDVGGGPSLGLRFGMTGRLLLDGSPGVEHLLYGPTGLDRRWDRFAVAFDDGGDLRLPTFGSSSRGWPAGSISPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH8</accession>
    <name>A0A7K0JPH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000139">
        <property type="protein sequence ID" value="MST31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="12181" checksum="D7D65BCF04779297" modified="2021-04-07" version="1">MSEGADATQQFFEFATEFADGERWQLLRAKGWDDFEERLAETIGDLPVRRRQALVMLLFSLVEGFVDPPDVRAWIDDHDLLSDDGIEAMIAWLRLRRAEAPEVSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP5</accession>
    <name>A0A7K0JPP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000157">
        <property type="protein sequence ID" value="MST31867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="28098" checksum="A20137E2B9F12BB1" modified="2021-04-07" version="1">MATGTEAAGAFDSGLTTPDFAACLSMGLQPVGLVQGFFCGQLSSWSNYQAAVVTNYPCAFGWRGGQDHPPPGWLGTATGLDDAWTTAFATAHQRLAEEATARGAHGVVGVRVEMSHPTNDRSTEVHLFGTAVRLAGAGAGPLWTTRIAGHKLAKLVEAGYAPVSVLYARCTAVMYEGCYMEHWGPNMVGAGSPLEPIQDVHNLARSRALQQAWRQAGSASLYDVELGAHEVEGSTTYVTCQILGSLVRRVRPTLPLAAPVTTVGLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ7</accession>
    <name>A0A7K0JPQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_04010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000166">
        <property type="protein sequence ID" value="MST31891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="300" mass="30085" checksum="E38F607D72E51DAD" modified="2021-04-07" version="1" fragment="single">MPSPHRHPGGATRSPAGTPSTPPTPPPPRRGLLLAVVLTAQLMVVLDGTIVNVALPGIQRALHFDTASLSWVVNAYALTFGGLLLLGARCGDLFGRRRSFLMGIAVFTAGSLACGLATTGGMLVAARALQGAGGAIASPAVLALLMGSFAEGRARMRAVGTFAAVSVAGAATGLLAGGVLTQLSSWRWVFFVNLPIGAAVLIAGALVIAGTGSQEGRFDLLGALSSTGGVACLVYGFVRAGAAGWLRAETLVAFATGAVLLVAFAVVETRAGSPLLPLRLLADPRRSGALAARSLVSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW8</accession>
    <name>A0A7K0JPW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000192">
        <property type="protein sequence ID" value="MST31996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="489" mass="52002" checksum="ABEDBCDE0C4F2D01" modified="2021-04-07" version="1" fragment="single">MTQPLRLATGTELLGAWQGSAYASQPCLIKRRDGQVLRVSQLIYAVAAALSESEDLHIVFPAEEGAESADLHELAARVASRSSRDVDASNVAFLLQTKLAPLGVLDWGQAPQQLPRPQAVLALRLRFKVVPERLHRRVTSTLTFLFWPPLVVTALLALAGGDIWLAVARGHSAFVATGAVLDHPALILAVTAMTVFAAMIHETGHAAGTRAGGATPGVMGAGIYLAWPVFYTDISDSYRLSRGGRLRADLGGVYFNVLTLLAAIAAYGATRWSPLLVFVAVTHLEVLTQFLPFVRLDGYWVVSDLVGVPNLFAYLGPVVARLTRAETPASRARLAEIRPWARRVISGWVAATTVVLGVELLIVGWLGPRLVTQAVEAMIGRARLLGLAVSAGRPVIAVVDLFDLVFLAVPAAGLLYMGALLTGRAVGAVRRWRRQHPARAVSLTGALLALAALQILTVVRGLLPSPPASPGYPGQPLALGRPPSMAVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX9</accession>
    <name>A0A7K0JPX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="25544" checksum="B4F418336EFDDD8D" modified="2021-04-07" version="1">MSRQGLRSGHAERIERIGFYIDGFNFYHGLRAKGWARYRWLDYRALIDRFVRDGQRVELAKYFTTRVTDVESRQRQDRYLQALGVRGGLDLIEGKFEMRSKQCGECGKWFKRPQEKYTDVNIATHLLLDALDDQVDTVAVITADSDLLPALTAVTARFARRFVLIDPPRRHSDELAKLADAHLHVPENWLRQCQLPDPVEYLNRKSKVRHVYKPDGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY1</accession>
    <name>A0A7K0JPY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="20866" checksum="C183A2C3C1E2ADBD" modified="2021-04-07" version="1">MRRHRPLRYAAADLTVAAVGRSSAAELIASDASAFVELRELDVPARAGAQAHLVVGYPEFRNVLFYRLQRAGQGALAAALRRLWPPMPLLEIGCPSIGPGFVISHGHGTVISARAIGRRLWVHHQVTIGWTYGQGAGMPTIGDDVFVGAGAKILGPVRVGDGARIGANAVVLRDVPDGATAVGVPAEVIQRGGSPGTGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY9</accession>
    <name>A0A7K0JPY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="56" mass="5709" checksum="F2100834D96A7BA3" modified="2021-04-07" version="1">MAVVAFGVAGVAGSPFIGHQRSATSITMGVATSVEVISLALYLFGSQQPRPATTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ16</accession>
    <name>A0A7K0JQ16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000190">
        <property type="protein sequence ID" value="MST31987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="286" mass="30959" checksum="927E707A34A985C0" modified="2021-04-07" version="1">MADVSVVIALYNGAATIGEQLDALASQTLSGCEIVVADNGSTDGGPEIVRSHRVGARLVDASQRRGQGYARNAGASAATGSKLLFCDSDDVVDTGWAAALADALDRWDVVGGFLEERTLNEGIEGWRNPSSAIFTARPLPYGGGGNLGIRRHVFEAISGWPTDLTGSGEDNVLCWRAQLAGYSFGHEPSAIVHYRWRHDLSAHVRQQFVYGRQLPIVQARFPQFEPARVTPWWKTLGWLGTHTPLLFRRRTVGLWLGTAAYRLGMAAGARVSDQMRVRSDPDSGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ55</accession>
    <name>A0A7K0JQ55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZnF_CHCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_04835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="7">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="416" mass="44389" checksum="CCC6DF1B71AA269D" modified="2021-04-07" version="1">MTGPGPSPIRAACDRHSLADVAARTGIHLPTSSDQINGACPFPSHHHPDRTPSLRLHLDTGRYHCFGCAAHGDVVQWVRDAEGLDVRSAIAHLDRHAPITNTWAGQSPRWPTNGTLSPASWERPDSERSTPDQTRAALAAAWDLFTAPEHHHAGVAYLARRGITIAPLEHSTGRPEVGHTPTGPDTLTRTLLADGFDPDTLVDAGLTLRSPDRLLDAYRHRVLLPVRDPAGAVIALLGRHTGPPGPPKYLNPPRTAVYDKSRDLYQPLPPPSADGHVVIVEGPLDALAIATAALTANLAHRYCPLTQSGRQLSPHQIRQVRHLDRRPVLAFDADPAGQQSTTRIGALLALAGCTPSVARLPPGEDPASWLARRGVHGLDAFGEKAVPADRRRAARPGASPPSPPDLSRPEAAGVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD6</accession>
    <name>A0A7K0JQD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoinase AllB</fullName>
            <ecNumber evidence="4">3.5.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">allB</name>
        <name evidence="4" type="ORF">GHK86_05395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000226">
        <property type="protein sequence ID" value="MST32160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="73"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="465" mass="48737" checksum="215CD5F2173D4E45" modified="2021-04-07" version="1">MPSNGRSANSAARSASRPVRESFDVVITAQRAVLPDGEQSCAIAVAGGRIAAIEPLSQRPPAHRTVTLTDDVVVLPGLVDSHVHICEPGNTDWEGFATASLAAAAGGVTTLVDMPLDCVPTTTDVAALEVKQASARGQCHVDVGFWGGVVPGNLEELSALSDAGVLGFKCFLVDSGSDEFPPVSAAEMEQALSVLADTELPLLVHAESAEVATALPMVNSAHYPDYLRARPRGIENLAVAQVIEAARRTGGHAHICHLSSSDAVPMLRSAQLEQVRITAETCPHYLALCAEDIADGMTTLKCSPPIRERANQGPLWNALGSGVIDAVVSDHSPCTPSMRQAASGDFGAAWGGIASLQLGLPVVWTAASARGFSLSAVARWMSEGPARLAGLPTKGGIEVGMDADFCVLAPEERFEVEAGRLAHRHPGTPYDGRSLLGVVRETWLRGRPIDRSEARGQLLSGRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV9</accession>
    <name>A0A7K0JQV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021831">
        <property type="entry name" value="ParD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11903">
        <property type="entry name" value="ParD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="121" mass="12862" checksum="DB6EFA1FEDECB375" modified="2021-04-07" version="1">MTSTSPARIDDDLYASAKLVGEALSRSASQQVGHWARIGRELEASATTSQRDIAAVLAGARRYDTLSAQEQAIVRAEWSERMDERRAALDLAATFTASGASYSELDDDGNVVQHPPAAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR27</accession>
    <name>A0A7K0JR27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_06560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000281">
        <property type="protein sequence ID" value="MST32381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="28396" checksum="7A5B1B51D5943F2D" modified="2021-04-07" version="1">MRPVGEDRPETEELTPETTFRRSIEEGRRRLRRGPVVLVATGLVGGIDIGIGVLALLLTESVTHSALLGGLAFGSGFIALALARSELFTEGFLLPVGAVVARKGSVRSLVRLWVVTFLANLASGWLITYLIIVGLPSLRPIAVSTGRYYALTIGLGGRAFALAVLGGVVITLMTWMQHSSESIVAPVVAAEITGYLLGGARLDHSVVASLVMFAALHTGHAGFGYGRWALAAGWAALGNLVGGTGLVTCLRLLQVPHRLRLERERPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR94</accession>
    <name>A0A7K0JR94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2017 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="54"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="18603" checksum="EE2DB71DC24E6606" modified="2021-04-07" version="1">MGAFATGRRPPGVSLFDRRPIRRSRAGAYTVHLGSDERAVLASLPGQMRELLATPEDPSLRRLFPPAYAAPQDQARQAEFQRLMGEDLLARHQEALDVLEATAAADELTAEQLDGWLRALNSVRLLLGTRLEVSEDDDADPSASPAHALYYFLGYLQECGIEALAGEAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL8</accession>
    <name>A0A7K0JRL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF445 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000334">
        <property type="protein sequence ID" value="MST32575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="426" mass="45888" checksum="5254922AAFE0026E" modified="2021-04-07" version="1">MMRSGHVLRLGADQAVAAARLRRMKLTAAALLALAAAVFVVSTVWLGPSPLRGFLQAGSEAAMVGGLADWFAVTALFRRPLGLPIPHTALVPRKKDELATKLGEFVTGYFLTPEVLGAQVTESGLVERAGLWLAEPEHAEQLAGGLASALAAGLGAVDTTGLEDSVLDLVRRHQGSRSWAPGLGRLLERAVDGGAQRPLVDLLAARCREYLAAHQAALHPVVKRFIEDRNWLTALVTTDRLVTRLLRDAQFELARIERQADHPVRVALEDLLRRLAFDLRYDPEAAARLDGLIGRLLDDPQASAVVRRAVGEAVETVRRSLGDPTSVLTARVADTVAHLGKRAAVEPGFHDEIEDGVRRVVTWAVDRYGGAVTALIRRQVEAWPADAASRRIELAVGRDLQYIRLNGTIVGALAGLLIHAVGVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN4</accession>
    <name>A0A7K0JRN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000334">
        <property type="protein sequence ID" value="MST32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="112"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="26815" checksum="B5F1550A7E825A8F" modified="2021-04-07" version="1" fragment="single">MDPVRLAELVQIVGGTPAGRFDPEGVVEAATIHSERIHRASLFFALSGTRTDGHRFVGDAFANGAAAAVVARGRVGELAAAGPLVEVDDPRSALQALAAWWRRRLRAEVVAVVGSNGKTVTKDALVHFAGYGRRIYGSPGTYNSQIGVPLAVLACPRDCDVAVIEAAVTEPGEMARLEEVVRPDHVVVTNLGTRWSSHFADRAGQAAELLRMAARLGDRSWLLVGEDAPELAAAPPGAARRLVTDDSADLPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV4</accession>
    <name>A0A7K0JRV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000358">
        <property type="protein sequence ID" value="MST32678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="9"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="454" mass="48776" checksum="1F1202056BC5CD7D" modified="2021-04-07" version="1">EHDRLTGDHLYDVDHPEVVARREDVGISGAVLLSARDFELALAGIDQARYYAHPGGGVAQHAPFALAGYWTVAQRRGLRLEQLTGTGQADLFLTYVGCPPLEQIPPAAALSINCDIVEFTAEHLPRWVPISMAAYNGADSGLNAYQELAALLAACVDHLEEVRRRGRVPLEHLAHALGGVSFRVGMDFFEDIAKLRVARKMWHDLLAGRFGITDERALRLRIHIVTAGSAMTYQEPINNVVRGTLMGLAAVLGGVQSMGISAYDEALSVPSEQAHQQSVRIQQILLHETNVAAVADPLGGSYYLEALGAELEDRAWACFEDIQARGGFVACLESGHLQRLAADNQLALEDAVASGERGIVGVNVAPSDHDPFGIDGFPGAPDAWERGMERLATLRAERDGRLVTQKLSELASACRGGGNVMAGVLAAVGADATVGEIGDVFREVYGSWTFPVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS63</accession>
    <name>A0A7K0JS63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000389">
        <property type="protein sequence ID" value="MST32788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="370" mass="38840" checksum="CAAF9A4815EC7165" modified="2021-04-07" version="1" fragment="single">MLAFSPLDAYSGMGARTRAVIEDLVALGAEVVPISVGEGDDGATLRAGSATLRVEAVTVGSKGGLLPRLGWRLRQLAPSLDALVMEGAMFVPAVTAAGARCPLVWDVNELETLHYRRLPPAPATTARRAAWRILEEWAARQAAVVVAISDDEADWCSRLLPASRDRLAVVGHRVPRPPSISISQPTRTRRPDWGETDPRIVFVGNLGAKHNADAARWIVEALAPELQCAATVLLVGPGTETAGSGRIGRAHVVGLGAVEDLSTVIGSDDIAIAPLAAGAGVKTKVLDYLDLGCRVVATPVSLEGIADPPGVVRAELDGFAGALRAMVSSPEPVALLRRRGEQQRAWLGRHAAPAGTQAGWRDVLARLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS83</accession>
    <name>A0A7K0JS83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="14341" checksum="9E10CB4B142110F8" modified="2021-04-07" version="1">MTVVSADDTEVVRPKRSWPAEYKLRVLAEIDAAKVSGDPGAVGEICRREGLYSSLVSEWRHQRDRGALEALSDKPAGRKPKDRGDTELARLRARVAALEAELASANELIEAQGKVSALWQERSRRSAENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS90</accession>
    <name>A0A7K0JS90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="754"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="840"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="878"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="916" mass="94138" checksum="651EA8C22A064AB3" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB1</accession>
    <name>A0A7K0JSB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-quinone oxidoreductase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000400">
        <property type="protein sequence ID" value="MST32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="131"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="373" mass="37929" checksum="34A2A8A6E1D915C1" modified="2021-04-07" version="1" fragment="single">MPLSIVVPLSVAVPLAVAALLAAAGDALPSLVRDVVAIATSAGTAALCGLLLAGSGSSRPVYWFGGWLPQHGRAIGIDYTVDALGAGFALLSAVLATIALIYSRSYFDRMGGRYPALVLVFVAGMTDFSLSGDLFNMFVGFELVAITAVVLTGFYADAEAPLQGAINFAVTASIGTLLFLVGIALLYDRTQTLNLADMGAALAGHRLGGAVVVAFAALLAAFLTKAAIAPFHFWLPDAYGTAPVPACVLFAGVMSEMGIFGIARVWTTVFAGAHLPGGTGGLTVGLCVLGSVTGLVGAVMAGRQRRLRRMLGFVTLAHTGLYLLGIGLLTSTAAAAVAILVVGDGLVKAGMFLAAGVAHQRTGPVDPWHGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC1</accession>
    <name>A0A7K0JSC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000402">
        <property type="protein sequence ID" value="MST32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="33833" checksum="48C5E22B1E70AD03" modified="2021-04-07" version="1">MNRRSPTPPRPGEPAVRFVDVTHRYGRHRALDGMSLELEQGQTVALLGPNGAGKSTTIGLLLGLLEAQAGTVEVLGTSPRQAVAAGRVGAMLQTGAGSGLPPGVRVDATLRLVRRLYRRPAPFDVTVERSGIGRLLDRQTQRLSGGQAQSVRFALAIAGDPDLVFLDEPTAAMDVAGQRAFWEMIRHFSREGRTVVFATHHLQEADETADRVVVLNHGRVTADGPGAVLKAAVQAHRVRFWCPRPPVGVLDGLEGVTDVAVRGQRVDLASLDADATVRDLVHRRIEFSSLEVTGAALEDAFVALTSRHHERGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD9</accession>
    <name>A0A7K0JSD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_07085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000309">
        <property type="protein sequence ID" value="MST32484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="76"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="160"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="266"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="442" mass="47997" checksum="A7E3ABC5BDA8B526" modified="2021-04-07" version="1">MLRRTVGTTPRAYPPGPARAAQRPRAPPGAPGPLRYDRPVTTTAAPEASAGGDEDRVAALVDRLLAEHPPASTPERDFLGAQFDAGLAWVQFPEGLGGLGLSRRLQRVVTERLSAAGAPMLLGRNPIGYGMGAPTLLAHGSDAQQRHYLRPLFTGEHIWCQLFSEPGAGSDVAGLATRAVRDGDEWVVNGQKVWTTLAHQARYGMLLARTDPDAEKHKGLTYFVVDMHAPGVEVRPLRQMTGDAEFNEVYFTDTRIPDAERLGDVGEGWHVAITTLMNERVSIGASVGGRGSGAIAAALRLWERRPDKDPVLRDRLTALWVESEVHRLTSLRAAANAMAGTPGPEGSTSKLHFAELNKRIYELCETLLGPEGMLYDDWTMRRPDSAGGFGGIPQRMFLRSRANSIEGGTSEIMRNILGERVLGLPGDVRTDKGRPWSEVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE4</accession>
    <name>A0A7K0JSE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000415">
        <property type="protein sequence ID" value="MST32868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="609" mass="65156" checksum="CDFD153E76A46284" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH3</accession>
    <name>A0A7K0JSH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">GHK86_09195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="WJHE01000423">
        <property type="protein sequence ID" value="MST32892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="291" mass="31871" checksum="74496D3F3259CE71" modified="2021-04-07" version="1">MTSRVTKAVIPAAGLGTRFLPATKAVPKEMLPLVDKPAIQYVVEEAVGVGLTDILIVTGRNKSSIDDHFDRSPELERHLEAGGKDDELAVIRALAELAEVHTVRQGEARGLGHAVGVARRHIGDEPFAVLLGDDIMDPRVGVLAGMLRAFQERQRAVIALREVPREQISLYGCAAVEVVDGPLVRLEDIVEKPSPADAPSDLAVMGRYVFGPEIFDEIERTPPGKGGEIQLTDAIKRLLGEGEVYGYTFREGRYDVGNKQDYLRATVEVALQREDLGPAFREWLLHRLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI5</accession>
    <name>A0A7K0JSI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="16797" checksum="50203BBD942BEFB1" modified="2021-04-07" version="1">MRLAEALAARADAQARLQELRSRIRDNARHQEGDVPAEDPNALIVEADRVAAELTRLVRAINATNAATPVEGIGTLTDAIAERDGLAARRKVLVDAAGEASGSGGLRLMRSELRMVTALDVPDLRRRIDELSRQRRQLDLRIQAADWTTELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY8</accession>
    <name>A0A7K0JSY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PAC2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000470">
        <property type="protein sequence ID" value="MST33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="30506" checksum="7E41E6602FCEB04D" modified="2021-04-07" version="1">MSDLATLHSWPTLEKPVLVVNLDGWIDAGQAAGTAMTTLRELVDPRLVATFDGDELLDHRARRPVLRIEHGVDRELRWPEIRLEAGTTAGGRAVLLLSGPEPDMRWHRFTGEVVSLASRLGVRMVVGLGAFPAPVPHTRPVRLAATSTDASLAGQIGVVPAVIEVPAGAQGVLEHAFGQAGVPAVGLWARVPHYAAALPYPAGAAALLDRLGPLVDVEVDTASLHAAAAVTAKHIDQLIAGSDDHAALVRQLELSHDEEEGLAGTQFGDLPSGDEIAAELERFLRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT04</accession>
    <name>A0A7K0JT04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000474">
        <property type="protein sequence ID" value="MST33075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="28967" checksum="D705D3C92380FF7A" modified="2021-04-07" version="1">MTAPGWVGYFGLERTPFGKRIAARDLFARPAHAEAVARINFCVAESALGVVTGDVGAGKTVAARAAVAGLDPTRHQVIYIANPAFGTRGLYVTIVRALGGEPRYQRAELMVQAADLLAAEEAERHRRVVLIVDEAHLLEPAQLEELRLLTNAEMDSASAFAGILLGQPTLNRQLRMGTFAALDQRIVTRYAVRGMDIGESAAYLRHHLALAGRAEPLFADDAIARLHRVSGGLPRALNNAATAALIAAAGDAKHIVDDHCAKKAVAELTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT06</accession>
    <name>A0A7K0JT06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000475">
        <property type="protein sequence ID" value="MST33081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATA-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="403" mass="44415" checksum="E18487390C5EE887" modified="2021-04-07" version="1" fragment="single">MSEAPCRFCGREAIPGRPYCSPCNRGVGRSRGRCGACAADDRFLYDRLCYRCRQNADRRCQRCGRAIPIGSVRGEHGEVICGPCGLRHALDEVLPAGGVLDPLRPAILAAEPLTTGRWLKRSRQLLAAVHNGRVPLDHEALDTLGHPRSVEYLRALMISAGILPPDTGRDLRRLERDLPDLLAAVAGQDRKAVTSWVRWAVLHRLRRLDPGRLALAVSNDRRKIRQVTAFTATLAEQGRCLSTCTQADLDTWFAGPGAARWSLRPFLAWAARRHHLPARLELPRAYKAAPSTPIDAEQRWAIAHRLVTDTTLSPADRVAGALVVLYAQPLNRIARLTTDHVAVHDDHVELHLGPDPLVLPEPFATLISSLPRRRRQGTAEQLTTTWLFPGGHASQPLTANALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT16</accession>
    <name>A0A7K0JT16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000369">
        <property type="protein sequence ID" value="MST32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="50" mass="5072" checksum="428FCEE258C2C9AE" modified="2021-04-07" version="1" fragment="single">MLLVVGRGGRGGDPRSVGGRCRDRCCARAGQGAIIGVGAIAYPAEWQAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT35</accession>
    <name>A0A7K0JT35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000486">
        <property type="protein sequence ID" value="MST33105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="13197" checksum="278ED89E5258C879" modified="2021-04-07" version="1">MPTRATADPDVVDDEAAQRFELRVGDDVVGIADYRPIPGGLAVTHMEVPHRFEGRGFASRLAEVLLHDARRRRLTVHPVCPFLADYVRRHPEHAAATRHPEATAAPAGARPRPDREVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT47</accession>
    <name>A0A7K0JT47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplQ</name>
        <name evidence="6" type="ORF">GHK86_10375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000491">
        <property type="protein sequence ID" value="MST33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13795" checksum="9777AF4A1C6C640E" modified="2021-04-07" version="1">MSGIPGRPKKGPRFGGDAAHQKAMFGNLVASLIAAEAIVTTEAKAKALRPVIEKCITKAKKAHAHPETAVHQQRQVVAFIRDKDMAHKLFAEIGPRFADRPGGYTRILKLGPRHGDNAPMARIELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT92</accession>
    <name>A0A7K0JT92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000505">
        <property type="protein sequence ID" value="MST33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="5">
        <location>
            <begin position="33"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="17987" checksum="9429F4C3D0041325" modified="2021-04-07" version="1" fragment="single">MTLTRGRVQELLAAGGLHPSRALGQNFVADPNTVRRIARLAGVGPGDRVVEIGAGLGSLTLALAETGAAVTAVEVDRGLLPVLRRQVGGAGVEVVGGDAMHLDWAALLGAGPWVLVANLPYNIATPLVADLLDGVPAIARMVVMVQREVAERLAAGPGDAGYGAVSVKVAYWATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT99</accession>
    <name>A0A7K0JT99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2630 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000508">
        <property type="protein sequence ID" value="MST33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020311">
        <property type="entry name" value="Uncharacterised_Rv0898c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10944">
        <property type="entry name" value="DUF2630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="7496" checksum="4F232B2CA8672D83" modified="2021-04-07" version="1" fragment="single">MEDAQIVQRIDELVEEEHRLERSHTDEPLDAEGLARLRHVEAQLDQAWDLLRRRRARRAAGGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA7</accession>
    <name>A0A7K0JTA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000381">
        <property type="protein sequence ID" value="MST32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="378" mass="40686" checksum="EB6EA9C381915626" modified="2021-04-07" version="1">MSRILLSPPHMGDIERQMLLDAFDSNWIAPVGPDIDAFEREFAEVVGVPHAAALSSGTAGLHLALRLLGVGPGDEVIVPTLTFIATAAAVTYVGAKPVLLDSELATWNLDPDLLAEELAAAAKRGKLPAAVIAVDLYGQCADYDRIVPLCEEYGVPLIEDAAEALGATYRGRPAGSFGRIGVFSFNGNKIITTSGGGMLVSRDGDLVARARNLASQARMPVVHYQHEEIGYNYRLSNLLAALGRAQLRSLPDRVRRKREIFAFYRGALADVPGIDFMPIDPAGEPTCWLTCILVDPDEHGMDREKLRLHLDDEGIESRPVWKPLHRQPALADARCEAAPVAEHLFARGLCLPSGSSMTPADLGRVVGAIGAVPKWKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA8</accession>
    <name>A0A7K0JTA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000510">
        <property type="protein sequence ID" value="MST33185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="424" mass="43246" checksum="7434EAD87AF59BCE" modified="2021-04-07" version="1">MPEAGPAPQAEASTPVKTTSGSSLRALRSRPFRIYFVGQVVSASGTFLQQTAIGWLVLQLTGSARDLGLVLAATGIPSLLFGPWGGSVADRVDLRKLLIGTQTLFGLLAALLWALAAAGDASVAALVIIGATGGVVQIADSPARQALVSRLVGPDDLSSAVSLNGVVINSARVVGPALAGVLIVTVGTTVCFGLNAVSYLAVIVALLLIQPREAVGPVPPGRRGVKDGLRYAAGRQQLWLPLLMMSVVGLLAFNFSVILPVFAKDTFHGTGGTYGLLTTMLSIGAVLGSLSVGLIHHPRRPYLLAAALGFGVTLGATAASPDVVTACVTLLLTGAAAFCLVTLCSTTLQLHTSSGFRGRVMALWVFVYLGTTPIGSILTGWITSAGGPRVALLVGSGACIAAAALAFFVHTPPDPDLALTDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF9</accession>
    <name>A0A7K0JTF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000525">
        <property type="protein sequence ID" value="MST33217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6163" checksum="4C94B6DBC431221A" modified="2021-04-07" version="1">MWRTWSGARVGPRQIVAMLAVLAVLVAAAVELGRPSLVAVGLVGPVLVGLDCAAGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI6</accession>
    <name>A0A7K0JTI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="233" mass="24666" checksum="5C1274B550EFC57C" modified="2021-04-07" version="1">MSRIRDVLRRNLIVASIVALFVVGLVVSGAATGGFKASLASSSSCGYGYTCPPPSTTTTAPSTTISATNRTGPGDVVISGTTAGNTTVKLYDEWYGRSYYVYKATTTSSSSGAYSFTVHIDRTNHFYVVVNGTKSASVAAVVSLTKVYVTPPPANRPGTVSVRVTTNQANAVIHLFDLYAGARYYVQKAVHVAEPIAYGNGVWTFQITNVRATNHFFAVVNGVKSNTVTALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP8</accession>
    <name>A0A7K0JTP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000555">
        <property type="protein sequence ID" value="MST33308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7076" checksum="E35FE2BC4BD2210E" modified="2021-04-07" version="1">MTGVEGTLEPFSCPRCGETAEERFYGPCTACRAALGASQGGEGRQVEAERFEPRMHVTPNAVATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU3</accession>
    <name>A0A7K0JTU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000573">
        <property type="protein sequence ID" value="MST33361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="38457" checksum="B7763594A0DB66F7" modified="2021-04-07" version="1">MPPSMAELEGPGMHAAIARLRAAGPVGWVDAIGGWLVTGYRTAVEVLRDAASFTVDDPRFSTAQVVGTSMLSLDGPDHRRHRSPFVPLFVPAGIEERYGPLVEGHVASLLDRLAHRGRADLRPALSAPLAASVMADVIGLGDAGADAVLEWYAAIVAAVTAITAGERPGPAAAGALDHLGAALGADGRSCVPGGAAALSDVEVVSNVAVVLFGGVETVDGAVANVLAHVLERPAVLAELRRAPELLAAAVEESLRLEPAASVVDRYASADVTVGGVEIRRGDLVRVSLTGANRDPEVFADPDEYDLGRANVRSQLSFARGPHACIAMDLARLEARTALGMVLEALPGVRLDGPVEVHGLVFRKPLALPVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU18</accession>
    <name>A0A7K0JU18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000591">
        <property type="protein sequence ID" value="MST33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="587" mass="60127" checksum="3936C3ACC5AD4470" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU82</accession>
    <name>A0A7K0JU82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000616">
        <property type="protein sequence ID" value="MST33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="25890" checksum="0EB3EF8D415B2DBB" modified="2021-04-07" version="1">MGGGLPDERHPAPRTAGSRRTAGRTNTTLAPSWRPGDADQGASMQLPKHLAIAAATVVGAGVGVTGFVGTARGDARPVTYSACVSRFGGTLYRVTENGAPHCLRWDRTISWDQRGPQGAKGVTGARGPQGATGAPGAQGPQGAVGPQGAVGPQGALGPQGAVGPQGAVGPQGAVGPQGPAGTASLTETVATEPATVAAGQTGSATAACPPGDLVTGGGYQFPDSGAIPIGATISADTPVGGGWSVSLQNESTTTVGVIAWAVCLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF8</accession>
    <name>A0A7K0JUF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000641">
        <property type="protein sequence ID" value="MST33571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="65"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="499" mass="50804" checksum="E2DC2142F7EA7C22" modified="2021-04-07" version="1">ATGGSSTGGGASGKAAGYVTGGTLTQLIPSDPGNLDPLMTVTGVTRGLDSYAYDPLINEEPNGSLVSGLATSWTQSGDTYRFTLRKGVTCSDGSTLTPATVAANINYLSDPAHKSPLLGLLVPPGAKATADPATSQLSITLAQPFPFFFEDLSQVGMVCAKGLADPSTLAEGTDGSGPYVLSQAVAGQQYTFTLRKGYTWGPGGATTATPGMPARIVVKVVADPTTEASLVLNGGANLATVQGLASKPLSAAHLFRRSAVAPLGELWFNEGPGHATAAATVRQAVVQALDLPQIGQVLGQGQGTPATGMVTVAPKACPGDTVAGTVPSQDTAKAASLLGGRHLTLTLLYATDVGGDPASAFELAAQELRKVGIDLKLVGDTTTQLESVIFGTGNWDLVDVPIGVDTPNELVPFVSGPAAPQGENFAHIANAAYTALATKAAALPGTTGCTDWNNAEKQLFDALDVVPFENALEPDWGRGVTFSMVGGEIPPTSFRLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG3</accession>
    <name>A0A7K0JUG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000655">
        <property type="protein sequence ID" value="MST33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="624" mass="67514" checksum="E05899D196B605ED" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD0</accession>
    <name>A0A7K0JVD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-1,6-bisphosphatase class 2</fullName>
            <ecNumber evidence="4">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_12390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000621">
        <property type="protein sequence ID" value="MST33514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="10849" checksum="6A37C7E0C869433F" modified="2021-04-07" version="1" fragment="single">MPQPTTDAPDRNLALELVRVTEAAAMAAGRWMGRGDKEGADGAAVDAMRAVLGSVAMDGIVVIGEGEKDEAPMLFNGERVGDGSSPQVDVAVDPVEGTTPTALGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF0</accession>
    <name>A0A7K0JVF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000631">
        <property type="protein sequence ID" value="MST33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="223"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="448" mass="45994" checksum="097FF51CFB76D734" modified="2021-04-07" version="1" fragment="single">MGEGHDNRGRLWRPLRRRDFRHLIAAMAVSNVGSWLYSTVLIVYVYQRTHAPIWVGLVTVGRMLPSVAFAPYAGVLAERFERVRLMVILDVLSAALMAALTGVVAAGGPVGVAVVLAAVASLPLRVYDPAVAAVTPELVGADDLAAANTVVEVVAQGAILIGPGVGAVLLVLGSPAAAFALNAASFVWSAVTVSRIRVRSTPVDVSEGGSAGVLRQVLVGVRTLAGAPAAAVLAGYSIGASFVYGTDTVLFVALARHRLGLGSGGFGALMATTGIGSILGALLVPRLSSRRRLGPLIVVGMAAYTLPTLVYLLRPDPAIGLAVQVVRGGGTMVLDVLAVTALQRSVPKETLARVFGAFFTFVMIAISVGALLAPLGLRAVGLDGTLVLAGAGLPALGLLGWPALARMDRANLASLEAIEGRVRLLRAAALLESAPQAVLERLAGDATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL2</accession>
    <name>A0A7K0JVL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000801">
        <property type="protein sequence ID" value="MST33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="27597" checksum="0217842D7B759F2F" modified="2021-04-07" version="1">MLAPQTLAQLRAFAGAVDARAPGRLTGLYAVGSVALGDFRPPLSNIDVVAVADTAWDDAGLRAVQHSTRSLRQPQQPARVACLTWEQLAGDPAEVVAPGFVGHREVPGGDLVNPLTWAVLRNAGVCVRGPEYPDIGHGDVRSWAAERLSTWWRAWLERTHVGPLILRRNIAERLLEVARLGQILGSGRVVSKLEAGEALEGSGPPNQQRVVKDAVGYRRGTRMSMYWGPYERRRHALAYIRTVVDAVSTPVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM9</accession>
    <name>A0A7K0JVM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000799">
        <property type="protein sequence ID" value="MST33991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="27493" checksum="BD559E87DA09E60D" modified="2021-04-07" version="1">MWRAELHHLFRRTVVRVQLLVLFLVPVLLAVAVKLSGGPSSGRGPSFLDQVSHNGVFAALAGLTVCIPFFLPLTVAVIAGDSIAGEASLGTLRYLLTRPAGRVRLLAVKALTVVVYSVAAAVAVALGGLAAGAALFPVGPVVGLSGTSFSLADGIGRTLLAAVIVGVSLLGLAAIGMFVSTLINSPVGAMVITAGLVVAALVVDSVPQLAFAHPWLFSHDWLAFGDLLRSPVTWGGIRRDLLLQLGYVVVFGAAAWARFTTRDVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN2</accession>
    <name>A0A7K0JVN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000804">
        <property type="protein sequence ID" value="MST34001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="20606" checksum="3846BC914F6123E3" modified="2021-04-07" version="1">VLAARGFTRVVTGALSPLEQGGFLAVGFDVAERLHLLSLDVSTGLPPVPAGRALASARRADQEAVVRVDRSAFVPFWQLDADGLADALAATPDTRWRVARPASRWAAGQVEGYAICGRAGSRGFVQRLAVDPACQGRGTGRRLLLDGLHWMRRHGVRTAVVNTQVGNQSALNLYRQVGFREEPLGLSVLATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV3</accession>
    <name>A0A7K0JVV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">hisF</name>
        <name evidence="12" type="ORF">GHK86_14995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000814">
        <property type="protein sequence ID" value="MST34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="11">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="26819" checksum="94082D7BD8DD5F38" modified="2021-04-07" version="1">MRAVRVVPCLDVDAGRVVKGVRFQGLRDAGDPVELAARYDREGADELVFYDITASAEGRDTIREVVARTAEEVFIPLTVGGGVRTVEDARTLLRLGADKVSVNTAAVERPGLVAEVADVFGAQCTVVGVDARRRPDGDGYEVCTHGGRRPTGIDVLAWVAECERLGAGEVVLNSMDRDGTRDGYDLALTRAVADLVGIPVVASGGVGRLEHLVAGATEGHADAVLAASIFHFGEASIADAKAALGRAGVVVRPLPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY8</accession>
    <name>A0A7K0JVY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
            <ecNumber evidence="2">2.7.1.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolC</name>
        <name evidence="2" type="ORF">GHK86_15410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.92" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000852">
        <property type="protein sequence ID" value="MST34103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047590">
        <property type="term" value="F:5-dehydro-2-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="35101" checksum="DF0B5BE58E140D23" modified="2021-04-07" version="1">MLTGSPRPFEVLTIGRMGVDLYPLETDVALEDVATFGRFLGGTATNVAVAAARHGRRSAIISRTGEDPFGRFVHRALRELGVDDRFVSAVPELPTPITFCEMRPPDHFPLWFYRWPKAPDMQIRPEELDEEAIRSAALYWSTLSGLSEEPSRSAHLHAWHLRARAPLTILDLDYRPMFWSSPADATRAAGLALEYVDVAVGNLEEVAVATGEDDGDRAARALLDRGVRLAVVKRGPRGVLAVTNEERVDVPPFAVDVVNGLGAGDGFGGALCHGLLAGWPLERVLRFANAAGAIVASRIECSTAMPTTEEVEAAMTGRMPHAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW13</accession>
    <name>A0A7K0JW13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000706">
        <property type="protein sequence ID" value="MST33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="227" mass="24975" checksum="E77F2142270B80B6" modified="2021-04-07" version="1" fragment="single">MRQAWWRSGVVLATLVGSYHAVIRPWQVRWGATDEEVTARLPGDERIAEPATQVTRAIGVDAPPEAVWPWLVQLGADRGGFYSYDWLEDLFGLGIHSADAVVAAWQQLAVGDLVAADARRRGGWYVVDLRPAELLALQVADLRRGRPTSRADRPGWEFLWTFALRPTPDGTTRLVVRERVAVGRRPLRLLLTPVGIVSFVMTRRMLLGLAARAEAAHRGAGARGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW14</accession>
    <name>A0A7K0JW14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_15620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000869">
        <property type="protein sequence ID" value="MST34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="505" mass="53822" checksum="1423B6F49713C269" modified="2021-04-07" version="1">MATQSAPATAHGEFRRNLGWTDGLAMGLSIPVGGFALIGYSIGILGAWTAMLLWGVTCVIALLQNFIFAELAAMFPDKPGGIALYAHEGWRRYFSPVGALAAVGYWAGWSFGLSVYGLIIGQLLADQFFPHAKWTFFDGTQHIGLAVILGALAVVAVWALNVFGVRPAVRSNKIIGIVVCITIAVLIVGPFVTGHWHHRLTWGLGQPHQAWGGWKLAIVYMYVMCWTSYGTEIAATFSPEYRDQKRDSTRALASGALLTLAFLVLGPLSTTGAVGTKEIVANPVGFFIPVFSSIIGPAAGVVTIILCGALFLNMTAATADAGRALYGISRDGMIVKQLFKLNRHGMPGRAMTIDLVVNVCLVLFVANTLGILFASNLGYMIAVVFALSGFLLLRRDRPAWPRPIRRGPAWTGVAWLLLAFNVVLIVVGALNPSIAGYGGTTDQIIGVAILAASILMFLFRRLVQDRVPLQLREATPAVPGDAGLVAVPAYADGHAPVVALEVPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW74</accession>
    <name>A0A7K0JW74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000898">
        <property type="protein sequence ID" value="MST34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="9820" checksum="416C57E6CAF8541A" modified="2021-04-07" version="1" fragment="single">MTTATNGNSVPTAPEATLGVAVLGAGRIAGIHARSLQAAPGVRVVGVADPDRAAAERLATVLGTRPHARWEALLEQDGVDAVMICSASSAHAEQVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA0</accession>
    <name>A0A7K0JWA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000898">
        <property type="protein sequence ID" value="MST34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="70"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="377" mass="39903" checksum="B2E190EF8966464A" modified="2021-04-07" version="1">MSYEVKEVDPRDREVSRRRFLKRAGAAALAVPALSTVLEACGTSSPGSASAASFGANGKDPFGKHPNWTFALVNHVTTNPFFVPTRYGAQDACNLLGVSYTWTGSANSIVPHMVSAMNTAIADKVHGIGVPVIDPTAFIKPTDDALSQGIPVVAYNANPPANSKNNQMAYIGQDLFQAGVLAGNKILQFVSKGDLVGGMIATPGTANIQPRMDGAKSVLKPAGVDLVEVATGAQLSQEYSTVPSWYLGHKDVKFLYAVDDGSGEAVAQTITKYNLKGKVHGSGWDVAVPELKAIKAGSLDFSIDQQAYLQGFLPIVQLFLYQLSGGLMRPSNTDTGLLFVTTDNVDSYLSVPSRYEGSTTSEKVLTAPKSIAEVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC4</accession>
    <name>A0A7K0JWC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_16150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000913">
        <property type="protein sequence ID" value="MST34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="172"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="423" mass="43875" checksum="F48976B806B6D808" modified="2021-04-07" version="1">PVRAVGIATQRASAIAWDATTGRALGPGLGWQDLRTAGTCLELQADGLRLSPNESATKFAWLLDTHDPDRRPTTRLGTVDSWIAWHLSGGRLHVTDRSNAGVTGLLGDEASAWRSELLRRLRIPEGALPHLVDSSGTLGAASALPGEPPIGGIAGDQQASLVGQGCTRPGLAKATFGTGAMLDVCVAQRPAFRARGEGGCFPIVAWSRAGQVTWGVEAIMLAAGSAVDWLVEDLGVLVDAAESEQVAASADDTGGAAFVPALLGLGTPQWDFGARGAFLGVSRGVGRRQLVRAVLEGIAHSGADLLEAAEVDTGVHPATLRVDGGMSANAVFVQALADACRRPVEVCREREATTLGAGYLAGMAVGIWADEDEVADAWSPQVVVDPSDTDGAGGAGADAARDRWRAAVERARAWYPELTAVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF3</accession>
    <name>A0A7K0JWF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000928">
        <property type="protein sequence ID" value="MST34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="8571" checksum="197BA8D07DD9D91F" modified="2021-04-07" version="1">MPKGRIAGVVRSWDDEQGWGVIDTPETPGGCFVHFSNIAGSGYRTLHSGEPVLLTYEQPGFKQDGYDFRALTVWPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF7</accession>
    <name>A0A7K0JWF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000928">
        <property type="protein sequence ID" value="MST34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="19058" checksum="1B1E2FB557EAD852" modified="2021-04-07" version="1">MVMRTTKEPATVGEGAQPDGFAGFLAGLYPDLVASLGVYDSSRPVAEDIAQEALAAAWQHRGRVEALSDPRAWVYRVAINHSRSLWRRALVELSHQARLRPAADQTGEALEDGLAVRGAVRKLPRRQREAVALRYFGDLTVEQTAEVMGCAPGTVKALTNQAMTSLRGFLDQEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI5</accession>
    <name>A0A7K0JWI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1634 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000942">
        <property type="protein sequence ID" value="MST34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="18234" checksum="7C09EA3E0AB29218" modified="2021-04-07" version="1">MTHVSGPEGAARSGAATGEPPIELPPAARRGRRQLSAGEVARMEEKIRRVETAISLVLRVGVVLSVLVVAVGLGLMFAHHRPYLPVSGRFSYRNLTSPATPFPHSFRSLGRSIARGDGRGVIVLGVLILIATPVLRVAVGVLSFLYQGDRPMAAVTLYVLALLVGSFFLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ4</accession>
    <name>A0A7K0JWQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000974">
        <property type="protein sequence ID" value="MST34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="359" mass="37544" checksum="B43C747B5D108643" modified="2021-04-07" version="1" fragment="single">MPPRPLAARSGPPPAGALRWAAMARPPAPLHRAAAAVAIVRHRRLSPRAFRALCAVAVVGLSLIIVTGAAVRLTGSGLGCPDWPTCADGNVVAPWQFHAWVEFGNRLVTAALSVLCVLAVGAALVRSTRRRDLTWLALGLIGGLLAEIVLGGVTVLEKLAPPFVMAHFLLAVAFLADAVVLYHRAGLPEEPIPGRPGRARVTGTVVPLVTREQSWLARMLLVATVVVITLGTVVTSTGPHGGAPQAPRFSYSLHDVAQLHGSSVEVYLLFTAVTLWLMWRTGAPRSVIRRGEVLLVTLVIQGGIGYTQYFLGVPAGLVELHVIGAVAVVLAVLRFNLGLAARQVEAVPAAAPAAGPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ5</accession>
    <name>A0A7K0JWQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000944">
        <property type="protein sequence ID" value="MST34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="355" mass="37775" checksum="B91F35D35D0BCA12" modified="2021-04-07" version="1">GVGKTTTAAAIAVHAALQGRRACVVTIDPAKRLADALGLATLGNEPHPVAGPWPEPGGLWALMLDTKSTFDDLVHRYAGGSAQAEAILANRFYRNISGALSGTQEYMAVEKLYELHETGRFDLVVVDTPPTRQALDFLDAPRRLMRFLDNRIFRLLMMPTRAGLRAVNVATQLFLRTVSRVVGGEVVREALAFFTAFEGMEQGFRERTDRVEALLRSPSTAFVLVATPRAGATAEAAYFAAKLGEAGLGVAAVVENRVFPHFGVPAALLEGKDAPAPSASGYAALLANAADLDRVATSEDVHIASLVERTPGAALVRVPFLAEEVHDLDGLVTVARHLFPGPAERPAPVERPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS5</accession>
    <name>A0A7K0JWS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000981">
        <property type="protein sequence ID" value="MST34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10109" checksum="E11D5EE46C4240E6" modified="2021-04-07" version="1">TLTTCAVAIAETGTIILDHGPGQGRRALTLVPDLHVVVVAAEAIVAGVPDAVARLDPARPHTWISGPSATSDIELDRVEGVHGPRTLHVVLCAPPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV8</accession>
    <name>A0A7K0JWV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ORF">GHK86_17125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001004">
        <property type="protein sequence ID" value="MST34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="33950" checksum="59192E5E67C6D8D3" modified="2021-04-07" version="1">MLAYIPSPPTNGFNLGPIRFHLYGLMIALGVIAAVWLAQRQWERIGGRPRTFSTLALWAVPGGLVGARVYSLCTSWNVDTGGHWLRAFAVWDGGLGIWGGVVGGIATGLYGAHRLRLPWAPLFDCVAPALVLAQAIGRIGNYFNQELYGWRSNLPWAVKIDHPLIDPLTGRVIAGPGTFQPTFLYELIGDVAVVFFVLWAMRRFRIRRGFAFAVYCAGYTFVRFFTEYMRIDVAHRYLGLRLNDWSSIIVFAGAVVALAVWGRRPVGDDIAGAPLALHPSRYDHPTPGGAVPADAVPVPVEAPRNELPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ0</accession>
    <name>A0A7K0JWZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001021">
        <property type="protein sequence ID" value="MST34468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="24446" checksum="4D4E9925D3B91978" modified="2021-04-07" version="1">MDQRADVEFFFDPICPWAWLTSRWVVEVAAQRDLDVAWRFICLRMVNADKDYERDFKPGYVAVHGTGQKLLRVAAAVRAAEGRDRAGEVYTQFGGDLHVRGRRDELVAHWEEGFPAYLASVGLGDYAEAANDERWDAVLQEETDAALERTGRDVGTPIISFTRDGQTTSFFGPVISRVPRGAEALRLWDAVWEVATFPGLAELKRSLREAPQLADSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX14</accession>
    <name>A0A7K0JX14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000846">
        <property type="protein sequence ID" value="MST34089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="21557" checksum="F145F77752B72461" modified="2021-04-07" version="1" fragment="single">GRGNRFAIVKATEATYYTSPDFAQQYNGSYAAGMIRGAYTFAVPNNSSGAAQADYFVAHGGGWTAGGRTLPGMLDIEYNPYGAECYGLTHAQMSNWVRSFDNEYHRLTGRMPILYTNASWWNACTGGSAVAAQDPLDVAAWGPSPSPLPGGWGIETIWQYTDSNGLGYDGDRFNGSLAGLKSLAAGHPVSGGTGGGTGGGTGGGTGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX78</accession>
    <name>A0A7K0JX78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol system anti-sigma-R factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsrA</name>
        <name evidence="2" type="ORF">GHK86_17750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="11266" checksum="52EB516E364B2EBC" modified="2021-04-07" version="1">MDEHDHNPGAGGATARAGQPDCRDALDALYRYLDGELDDERRRTIHHHLERCSPCLEAFDFEAELKVVVAQRCRESVPESLRNRVADALAEASRTLRPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG1</accession>
    <name>A0A7K0JXG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_18180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001121">
        <property type="protein sequence ID" value="MST34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="270" mass="28622" checksum="0C9490E4A716E87A" modified="2021-04-07" version="1">AHLPFPLPLVLATLGGAALAGVVGLFSLRRMRRDYQGAILLIVSLIAAEIVTADVPMFNGSNGLTGVPKPLASLGLGLQAYQWSYAVWSLVIAFAVYAGVRWLSRSPWGAALRAMRDQEVAAGAIGLNITVLRMQVFVIGGAIGGLSGGLLVQYIGAWSPGAWGYAETFVIFTAMFVGGLGNYRGVALGILLVPIIFLEIPQFLPQIGYPGLIDSLEWILIGVLWMLSLYFRPQGLVPERKYVAVGSPLIPMGEGTRLASLAGGITGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG5</accession>
    <name>A0A7K0JXG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IstB_IS21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001120">
        <property type="protein sequence ID" value="MST34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17670" checksum="6EE15501E1AEA7B0" modified="2021-04-07" version="1">RGHPHLTGQQPPKLLQSVAVPSGTGKSHFTEAIGHACIDAGLTVAWFSIEDLGALVRRHRPDDSLNRAIRRICRAHLLIVDDIGLLPVSPDAAEGLYRLVDAAYEHRSVALSSNLHPAGFDELMPRTLATATVDRLLHHAHVCQTAGDSYRLTAATAGKGVTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM3</accession>
    <name>A0A7K0JXM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein GrpE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">grpE</name>
        <name evidence="4" type="ORF">GHK86_18545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001172">
        <property type="protein sequence ID" value="MST34715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="10436" checksum="930BECE67129ABDC" modified="2021-04-07" version="1">AAESLVEKLLPVLDIADLAVAHGAGEEVKQVWTALLDALEREGLERIDPAGGGFDPTRHEAVAHEPGDGAGEQSVAEVLRAGYAWKGRVLRAAMVKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY05</accession>
    <name>A0A7K0JY05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">groL</name>
        <name evidence="9" type="synonym">groEL</name>
        <name evidence="13" type="ORF">GHK86_18850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01001207">
        <property type="protein sequence ID" value="MST34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="478"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="548" mass="57119" checksum="DF9561A4135B5CA7" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY55</accession>
    <name>A0A7K0JY55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001280">
        <property type="protein sequence ID" value="MST34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="10699" checksum="346E9023C6ECD2A0" modified="2021-04-07" version="1">MSSGSVGYEGREPTTIDYSVDSSNIVDHIHWSSWGPQTAVGHGVWTEESCNPNCATGPVTNVPATITLGGVSAGHFTTMTERAGKLDKAYRYPANWALGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY68</accession>
    <name>A0A7K0JY68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001244">
        <property type="protein sequence ID" value="MST34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="260" mass="28329" checksum="722DBA100DC4F5FB" modified="2021-04-07" version="1" fragment="single">MSAAFSLPPTPATPAVPPAPLVSVVVPAHNEEAYLEEALTAIVEGMRVRHLAGEVVVVENGSTDRTVGVARRAAAGRPEIRVLQLRRPDYGAALRAGFRAARGELVANFDVDLVDLAFLDRALDRLGADPSLDVVIGTKRGAGADDRRTAGRRLVTGAFSLVMRYGFGLRVSDTHGLKLLRADPLRPLVDRVRSSRDLFDTELVLRAERAGLRLAEIPVTVEEQRPPRTPIVRRVPRTLAGLAGLRLRLWQADRRVGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY82</accession>
    <name>A0A7K0JY82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PqqD family peptide modification chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001306">
        <property type="protein sequence ID" value="MST34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13509" checksum="69C37B6EF23627C6" modified="2021-04-07" version="1">MSDDIAASAIDSQFAPRARPDVAWVELDGQVVAFDPVRMTSYVLNATAGLIWQLLDGSDTVEVLSADLAAAFGADLDQIRSDVLTTVRRFGDQGLLAGVTGQRSEDGSGDRDPDRSPSRFLLGPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN6</accession>
    <name>A0A7K0JYN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pncB</name>
        <name evidence="10" type="ORF">GHK86_20365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="WJHE01001407">
        <property type="protein sequence ID" value="MST35071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST35071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="28975" checksum="4E4E441865644BE1" modified="2021-04-07" version="1" fragment="single">MSAAASSALHTDRYELTMLDAALRTGRADVPATFEVFSRRLPAGRPAGVFAGLGRILEAIGRFRFGAEELAWLDGLGFLSPEALAWLARFRFSGSVDAYREGEWYAAGSPVLTVTGTFGEAVLLETLLLSILNFDSAVASAASLLVAAAGDRPIIEMGSRRTDPDAAVAAARAAYLGGFASTSNLEAGRRYGIPTAGTAAHSFVLAYPSEQEAFAAQLAAMGPGTTLLVDTFDVETGIRRAVEAAGTGLGGVRIDSGDLPAETRRARKLLDELGATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ2</accession>
    <name>A0A7K0JYQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001412">
        <property type="protein sequence ID" value="MST35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="21041" checksum="C38A5CE3BF5DED48" modified="2021-04-07" version="1" fragment="single">VNLGVRHASGDLVALLNDDALARPGWLARAGEVLERDPGIAAVTPKILYRTPFRAVGIDAEAWQADGDARELGRRIARATVAGRDVLGQLCGPGIHRLEIDEGGDRWRWSRPGHPVYVPVPPDAPDAEVRIDGEPAVGPLVRLINKAGSWLALDGILGDAGDREPDDGRFDQPFEHFAASGTALVVRAETWARVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS6</accession>
    <name>A0A7K0JYS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001427">
        <property type="protein sequence ID" value="MST35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7878" checksum="D35A8BB7A753918D" modified="2021-04-07" version="1" fragment="single">MLADILVALLITAVAIVLGVVVHPVLFFLIILAIVWLFARRGGRRHVGVRSRRRTPGRRPGSWGRWRPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU3</accession>
    <name>A0A7K0JYU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="11" type="ORF">GHK86_20495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001427">
        <property type="protein sequence ID" value="MST35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="10">
        <location>
            <begin position="8"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="34965" checksum="5547B234E1BAF8D5" modified="2021-04-07" version="1">MSSLAESSGKVRDIYRVDDATLLMVTSDRISAFDVVMAEPIPDKGRVLTAFTAFWLEQLGDLAPNHLLGLEPPAGWQPPAGATDLAGRTMLVRRAEMLPVECVVRGYLAGSAWVEYVRAGTVNGEPLPAGLRRSERLPEPIFTPATKATSGHDENIPFAAMVDLVGRERAEAARALSLEVYRRGAAMAADRGFLVADTKLELGIIAGELAICDEVLTPDSSRFWPAGEWEPGTVPPAFDKQPLRDWLEGTGWDKTPPPPALPAEVVAATRARYVEAYERITGRRFADWPGVGGRGGPDRTDGPDPDGRDHIDSPDDTNSKEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU8</accession>
    <name>A0A7K0JYU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">folB</name>
        <name evidence="4" type="ORF">GHK86_18570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001174">
        <property type="protein sequence ID" value="MST34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="3">
        <location>
            <begin position="89"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="17991" checksum="AEFFEE5D75E60778" modified="2021-04-07" version="1" fragment="single">MDQRRRAGAGPPGGAQRPPDGRGRRLPALVGDDPVERPGDRRGGAHPPAPDGLRRPPPRRGRPHPGRPRPRDAELLTDVGPATSGADRIELRGLRVLGTHGVLPEERSRPQPFEIDLDVFADLRVAGRSDDLADTIDYGAVATAAAAAVEGPHADLLEHLAERVAEAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX9</accession>
    <name>A0A7K0JYX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001483">
        <property type="protein sequence ID" value="MST35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="303" mass="32270" checksum="7BD5194D366FF4CE" modified="2021-04-07" version="1">MIAGSQAGGSRVGSLDGRVAIITGAGRGLGRAYARFFAAEGAKVVVNDNGCDPSGERPADDAAGRVVAEIREAGGEAVVSREDVADWEGGRRLVQTAVDAFGRLDVLVNNAGILRDRAIVTMQEGEWDEVIRVHLKGHFVPLRHAASHWRERARAGEEVRASVVNTSSTSGLQGNPGQSNYGAAKAGVAALTVIAAMELARYGVRVNGIVPTARTRLTESTPGLDEIVRPPEDASRFDEWDPDNVSPVVGWLAQEGCTVTGRLLYVFGGTVQPMTGWLREPGLERPERWTLAELDEQLGPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF8</accession>
    <name>A0A7K0JZF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-IB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001586">
        <property type="protein sequence ID" value="MST35288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:fatty-acyl-CoA reductase (alcohol-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="PTHR11011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="2">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="449" mass="50436" checksum="5F02EF71581B7FB9" modified="2021-04-07" version="1" fragment="single">QREARAELGAAGTPLLAARAERAREDWVKQRMVELGKARAQGLGWPDAYAYSKALGERALLDTRGELAVSIVRPSIIESSLAEPVPGWIRGFRMADPVIIGYARGLLREFPGLPEGIIDVIPVDLVVAAVLAVAARGPLPGGPDVVHAASGARNPLRYRQLVDLVREWFTEHPLADAHDQPIAVPEWSFPGRRTVQRQLRQATRTLGAAERALQSLPLRGGRADLAARLEERRDEAERALSYVELYGAYTETEAIFQVDRLLELHRSLPADDQRDFGMDPAVIDWRRFCQDVYLPSVVAHARVRQAPAAGTRRRDPRGATGLTREQRGRRAILSPDRQLAVFDLENTLIASNVVDSYSWLATRHQRDRSRVAFVLRTLRDAPSMLAADRADRGDFLRAFYRRYEGAPVERLRADGWQLWHDLLLVKSFPDGLRRVREHRSLGHRTLLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI4</accession>
    <name>A0A7K0JZI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001341">
        <property type="protein sequence ID" value="MST34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="9961" checksum="5F0ABCC7612C2652" modified="2021-04-07" version="1" fragment="single">MGECDAVGGLLPAWVAGEADLDERARAHVAQCLRCQADVARYRRMLRTLHALRSEPGPAAPPAMADILTDMDGRGRRRWTPGPWAAVALAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K058</accession>
    <name>A0A7K0K058_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001502">
        <property type="protein sequence ID" value="MST35189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="72" mass="7766" checksum="9CABB050FB240B20" modified="2021-04-07" version="1" fragment="single">MEDVLAASRFGAPEVHHLPGIPDLVRDADSVLAGYLSMSWAAPHLFGERLAAFTREARALLAACSPDGVFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K076</accession>
    <name>A0A7K0K076_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001516">
        <property type="protein sequence ID" value="MST35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13679" checksum="8C450BA23251CAF7" modified="2021-04-07" version="1">MREEVRCAWCGRPFVPSPGPGRPRRYCRRSCRQRDFEARRRAAEHGLADHELIVTRAALSRLDDAAYVLACAVEDVDRDLAGEHDEVDVARALAWLLDAARPLAELSRRGGLLAGGDGAGAVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K099</accession>
    <name>A0A7K0K099_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001532">
        <property type="protein sequence ID" value="MST35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="10879" checksum="7829FE107332EDF1" modified="2021-04-07" version="1">IGTGHLSLELGGPRQFGDHGPDPDFDRRAIEWISSGDVEGCLAEVTLDSLHTPGNATHGFMDFMLMMGVAGEGVKADYVDSLDLFHTMEAYFTWYPTGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMT1</accession>
    <name>A0A7K0JMT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADSL_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="5613" checksum="35F039AE0E918C2E" modified="2021-04-07" version="1">DDAAATPDFATALAADPRAGLGAGEVAELLDPAGYLGAAGAWVDRALAAHRSEVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN34</accession>
    <name>A0A7K0JN34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000036">
        <property type="protein sequence ID" value="MST31313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="16419" checksum="20BB9EA902188247" modified="2021-04-07" version="1">MDVSMTVNGSPRTDSIEPRLLLVHYLREVAGLTGTNIGCDTSSCGACTVLVDGESVKSCTMLAAQADGADVTTIEGLADGERLHPMQEAFREHHGLQCGYCTPGMVMAAVSLLKEIPDPTEAQVREGLEGNLCRCTGYHNIVQAVLAAAKAPTGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNB9</accession>
    <name>A0A7K0JNB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gcvP</name>
        <name evidence="9" type="ORF">GHK86_01815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000073">
        <property type="protein sequence ID" value="MST31470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="959" mass="100869" checksum="0575CA0755AD47F0" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JND4</accession>
    <name>A0A7K0JND4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">kdpA</name>
        <name evidence="10" type="ORF">GHK86_01880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000076">
        <property type="protein sequence ID" value="MST31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="572" mass="60830" checksum="039E43A27E566951" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF4</accession>
    <name>A0A7K0JNF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterodisulfide reductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_00060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="26913" checksum="97446A682996A05A" modified="2021-04-07" version="1">MSSTVTPHRKRDQASGYAAVPREEKQRLFDLVKADARFPDYLYGCYECGICVAVCPSARFYDFSPRRIAQAAAREDVDLVYQQIQEDVWECSQCFSCLRCPRGNNPGGIITIMREVAVNAGLASAKEALEGYSRIIYKIMSTGTQVSPDMLQPDAFPDWGPEVKAVSENLDLWRRALPPETHHTTTTGWAVAERTLIELYLIWMETGALAMIREVDEGLHMILEEVMEERLEEEGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL7</accession>
    <name>A0A7K0JNL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000075">
        <property type="protein sequence ID" value="MST31477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="26269" checksum="AB3C9B71E2911DA7" modified="2021-04-07" version="1">MPRPPGSRWKGDAEPAALAAWPEDSLGDRLWSDPSIRTALGVPPLREAQVPDPAVIRADPVQWNVALSLLVRAVVLDGIAVGDPRVVALLAVLGPVVEAELLAGDVAADEARRDGLEPSAVRSDFPAGDGPVFLVGCCALVHATWTAIGNDPLPAVLGVVSEVVERAVPGRGRTVAEVLFGAFGEHYSVERSEDVELVERLGAGTSGDPLRDLVSAGVVASHDVLRVGLEVLAALAELCTSSAVSVLDAAAPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL9</accession>
    <name>A0A7K0JNL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="35234" checksum="D0757C7EB7F0E34B" modified="2021-04-07" version="1">MQELTVATPGGSYPVLVGAGARHRLTELIPVGARRAAIVTQASIPWEVDAGIEQRRFTIGQGEESKDLETVEELCRGFARWGLTRADVVVGVGGGMVTDVAGFAAAVYHRGVAVVHVSTTLLGQVDAAIGGKTGVNLPEGKNLVGAFWQPAAVLCDVETLETLPPREYRSGLGEMAKYAFLGVDRLRDRSLEDAVAACVACKAAFVADDEREQGRRALLNYGHTLAHALETAGGYDLRHGEAVGLGLRFAARLARRLGRVGDGEVADHDTLVDAYELPAALPPGVDDQELLTVMARDKKATTGLTFVLDGPRGLEVVPGVPAEAVAATLAELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ7</accession>
    <name>A0A7K0JNQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_02075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000088">
        <property type="protein sequence ID" value="MST31517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="22375" checksum="8B5BAD389FC4B854" modified="2021-04-07" version="1">MTATATSWWTSEDPAEESGPMSDWAVGAVARRASTGDEEAWRELVRRFDGMIGAVGRRYGLSPADVGELRQTVWLRLVEHLVRIEDPQRVAGWLATTARHESLHMIARASRHTFGVDEILGNTADPAAPDVDARSLAADETAALRAAWKKLPPRCQRLLAHLMADDAPGYRDLSRCLEMPVGSIGPTRGRCIEHLRRLVAMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR4</accession>
    <name>A0A7K0JNR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="25992" checksum="D7B8980A1F0DBE13" modified="2021-04-07" version="1">MDRPPRLSLAAGTLRPGTTAEAAIRLAAAAGFDAVGLRPTPGWSATDVARRAADAGISILDIEVARIGTTEDEDADWLVDWAVEVGAAHVLVVSDVLDPSATAAGLHRVAARCAGSPLRPVLEFMRFTGVPDLASARAAVEAVGGSCIGILVDALHLARAGGEPTDLADIPAARLPYFQVCDAPASGPADGDLASEARYRRLLPGDGRLPLGALVAALPGRPISVEVQSEVGWSEPPESWVRRVHQAAAQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT8</accession>
    <name>A0A7K0JNT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="5541" checksum="0C04B0A2196556A8" modified="2021-04-07" version="1">MAELLGVSTWAVYESVRRGEPPIPPIRVGRRLVWPKAAVDRLLDGASGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW8</accession>
    <name>A0A7K0JNW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">fliP</name>
        <name evidence="13" type="ORF">GHK86_02295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000096">
        <property type="protein sequence ID" value="MST31561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST31561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="23200" checksum="19E80E0C67AC9F8E" modified="2021-04-07" version="1">MNLGGSLTKPSNSLEIIILLTLLSVAPALLVMLTSFTRVIIVLSLTRNALGLSTVPPNQVLAGLALFVSLFIMAPTLKAMYNDGIHPYMQGHITQSQAYTRTVRPLRTWMLRQTDSQSMQVFEPAGGVSSASKLSMTAIVPAFILSELKAAFTIGFVIFLPFMVIDLLVSSTLMSMGMMMLPPTLISLPFKLLLFVLVDGWALVVSTLIHSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP07</accession>
    <name>A0A7K0JP07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium-transporting ATPase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_00920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000032">
        <property type="protein sequence ID" value="MST31294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029569129" evidence="11">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="19243" checksum="0C20CC06B6648D8A" modified="2021-04-07" version="1">MIRHLRRAVLISIVFFAVCGLAYPWAVTGISQAFLPYQANGSLTAHGSAPVGQPWKGPLWFQGRPDPYTPDATGPSVADLGPRSKVLLHDVKARIAQLRAEGITPTSDLVTYSFYGSSANITPHSAYVQVDAVARARHLSPATLRRLVASHVTPAQFGFLGSPYVNVLKLNEALARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA4</accession>
    <name>A0A7K0JPA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycofactocin biosynthesis chaperone MftB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mftB</name>
        <name evidence="2" type="ORF">GHK86_03540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023850">
        <property type="entry name" value="MftB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03967">
        <property type="entry name" value="mycofact_MftB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="12787" checksum="792ACE1D70C59714" modified="2021-04-07" version="1">MLETVLTDDRLSDLPPFDPGRRWRLAPSVAVRPEPFGALVYNFANRRLSFLKSEDLRRVVESLAEHPSAESALGACGVGEGRRPAYVRALADLARSGMLEPVPPDPPPATANGAVGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE2</accession>
    <name>A0A7K0JPE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000143">
        <property type="protein sequence ID" value="MST31815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="11697" checksum="919701D9F936018A" modified="2021-04-07" version="1" fragment="single">MSLLALVFPGQGSQRAGMGAPWRDHPSWWVVDRLGAASGRDVAGLLLDADAETLRQTRNAQPATFALSLVILDAARQAGLLDAPVAAVAGHSLGEYSALVAAGALEHDEAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF7</accession>
    <name>A0A7K0JPF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="22756" checksum="F1470256E9FCF05F" modified="2021-04-07" version="1">MAAVPALQPSLLDLVADPSPEALAGRVERRVLGDGAWVDRCPGWLTGGELFPALVEGVAWRAERRPMYERVVDVPRLLAFYGPGERLPEPGLEAARSELDTYYRPELGEALATAGLCLYRDGRDSVAWHGDTIGRAAKEDTVVAILSLGATRRFLLRPVAGGPSLRLDLAHGDLLVMGGSCQRTWQHAVPKTARAVGPRVSVQFRARGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP6</accession>
    <name>A0A7K0JPP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_04270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000179">
        <property type="protein sequence ID" value="MST31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="27234" checksum="D6ECB9A9E94A3E9C" modified="2021-04-07" version="1" fragment="single">MRVLVVEDDDGIAEPLVEGLRREGFEVQRVATGAAALAVTDAELVLLDLGLPDVDGYTVCQQMRARSSVPILAVTARGAEVDRVVGLELGADDYIVKPFGFRELVARIRAVLRRVNGGMGSEAEPVQHLGRLTIDRRARRVFVDSTEVALSPKEFDLLGLLAEDAGAVVSRQQILEEVWDPHWYGPTKTVDVHVASLRKKLGHPEWIETVRRVGLRLGPTDGPDRPVEGADRPASPPAPPAATDTPSWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ3</accession>
    <name>A0A7K0JPQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000091">
        <property type="protein sequence ID" value="MST31534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="4">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="FlaE" evidence="6">
        <location>
            <begin position="188"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="5">
        <location>
            <begin position="330"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="40593" checksum="B05D9E2619E56D58" modified="2021-04-07" version="1">MLESLFTANSGLEASQAAMDVIGNNIANINTVGFKSSDVAFQSLFNETMAGASSPTASLGGTNPQQVGLGVAVVATPTNFSQGTAEATGNPLDVSIQGNGLLVLDNAGQTLYTRAGQLQLDANGSLVEPDGSYVQGWMATNGSVNTAAPLTHLTIPTTGTSVAGTQTSNITLTGNLNTVSPKTGPTMEVTVYDATGKASTLTLQFQPPASAGGAWTVAASDGAPSTTGSGLAYGTGTGSVTFNASGVNTNAGGTVTVTDNSGNKYTLNVANLSANALAESVAASNQNGSAPGTLESYSIGQNGQITGVFSNGNTQVLGQIALASFANEGGLQAVGSTEYAATANSGLPQIGTPGTGALGTLSPGTLEQSNVDLGQAFTNLIMSQRAYEANANVLSTSNTVIQSLLQATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU5</accession>
    <name>A0A7K0JPU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000188">
        <property type="protein sequence ID" value="MST31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="8096" checksum="3A6F15EBFA0F27BE" modified="2021-04-07" version="1">MLVFDLVAGLVIVGVLLAILLIGIAMSSRYQDTLELQRARRVVTPGRFRQQEFDEAIRRVVRSRQVERQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV4</accession>
    <name>A0A7K0JPV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000190">
        <property type="protein sequence ID" value="MST31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="206"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="382" mass="40997" checksum="46F97EB0153B940F" modified="2021-04-07" version="1" fragment="single">MATTRQQDRAGAGAERAGLGGRPRLVHVTTTDISLALLLGPQLEAFAAAGYDVITASAPGPFVERLRAAGIDHIPLRHATRAMAPQRDLAALAELTALFRRLRPDIVHTHNPKPGIYGRLAARAAGVPVVVNTVHGLYATPDDSWRRRAAVYGLERLAATCSGAELVQNPEDVATLRRLRVPADRLTLLGNGVDLSRFHPDDSDRAALREELGYGTGDVVVGVVGRLVWEKGYREVFEAAAALRQRRPEVRFVVAGPADHSKADAVDADEMRRAEAAGGVRFLGHRDDVERLYRAMDLYVLASYREGFPRSAMEAAASGLPVVATDIRGCRQVVDDGVTGRLVPPRDAAALAAAVETLAADPRAKIVKQTADAVFEVTGRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY4</accession>
    <name>A0A7K0JPY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="8578" checksum="2F08E99C4D35051A" modified="2021-04-07" version="1">MLVFDLIAGLFVAAVVLAILIIGIAQSDRYQDELEAQRHRRAVTPARLEHAELEQADRTFVRLHHPDQAHEQPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ33</accession>
    <name>A0A7K0JQ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="303" mass="32976" checksum="A976F9B2802F5093" modified="2021-04-07" version="1">MLVPVYNRAGMLAECLMSIRRQDTGLVVQVLVVDDGSTDASADVAARSGADVLRLPANSGLATARNTGLQAAEAPWVAFLDSDDWWSPDHLSTLWAARDGVALVATSALTVLAGRRRVVGSPFPWRIELRRPSDVLRPENVIAASAAMVRRDVALDAGAFALRPYCEDLDLWVRLLSRAHGRVLPRLTVGYRSHEGQMSHEQAMGTEFTRLVSDLRSSGLLTADSTRPFATIDAWDARPGSGTVGWLARQVRPGRIEPMQLTRLLASRAAQRQRWRLQPGAARRLQQPPAVAPAPAAPTSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD4</accession>
    <name>A0A7K0JQD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000134">
        <property type="protein sequence ID" value="MST31784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="80" mass="8414" checksum="37C4FE778211E41C" modified="2021-04-07" version="1">MTVRAYVLIQTEVGRAAEVAARARVLEGVASADDVTGPYDVIVTAQAGSVDELGRMVVSRLQLIEGITRTLTCPVVVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW3</accession>
    <name>A0A7K0JQW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RecQ family ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_04440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000186">
        <property type="protein sequence ID" value="MST31974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="233"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="528" mass="56510" checksum="88F7AA1B91276514" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR20</accession>
    <name>A0A7K0JR20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="8593" checksum="01957AC168CCF6B3" modified="2021-04-07" version="1">MQSLVAHVGAGGLLLAAIPLAASVLVGACLRRGRSNPNGPAIPFAWAAAGTLAVAALVGTVTILIGVYVLPTPVLLLAACGLSRHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR23</accession>
    <name>A0A7K0JR23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000281">
        <property type="protein sequence ID" value="MST32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="28996" checksum="14C50B3C723068AA" modified="2021-04-07" version="1">MTPLDFVVSLALVSVAAGVLGSLIGLGGGVVIVPVLTLLYHVDIRLAIGASIVSVIATSSGAAAAYVRERMTNLRAGMFLEIATTTGAVSGAYLTTLLPARLLFVIFGLVLGYSSFATFRRRHADTPLLVSHDRIANYFDLHGSYYDPAEGREIAYKVVGTKPGLALMYLAGLVSALLGIGSGALKVPAMDSAMHLPMKVSSATSNFMIGVTAAASAGVYFIRGQIDPIIAAPVAAGVLLGATFGARVLGRVTSRTVRLVFVAVLVVISLEMLQKGIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG0</accession>
    <name>A0A7K0JRG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000316">
        <property type="protein sequence ID" value="MST32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="193"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="336" mass="35451" checksum="1DD082D21A4C9334" modified="2021-04-07" version="1" fragment="single">MPLAARRLLSSRWVEPVGVAVVVGLVLAGSIAEAYPAHHYAGLHLRHHPFPALFAVLVLPAALLWWRRSHPVAVYLATVAGAAWWAASGQVYGAALVMVLVALYALAVSGQRWPVVAGLGAGGTLVIWLAGGLGGPWGWWGGPQLDMWAEMVAAGAVGGYVSARHRWAQSEQLRGEQLERARAEEIRQQVTAERLRIARELHDVVAHSMAMINVQATAAATLVGTDPAGVTDSLQAIRSASKDGLRELRSILDVLRQVDEPQLAVPLPDGHGLQALAEAARAAGVRLGFHCDADLQAAAPGTALAVHRIVQESLTNVVRHASGATAEVSITGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG9</accession>
    <name>A0A7K0JRG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Benzoyl-CoA 2,3-epoxidase subunit BoxB</fullName>
            <ecNumber evidence="1">1.14.13.208</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">boxB</name>
        <name evidence="1" type="ORF">GHK86_07395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.208" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000326">
        <property type="protein sequence ID" value="MST32546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017635">
        <property type="entry name" value="Benzoyl_CoA_Oase_BoxB_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03225">
        <property type="entry name" value="benzo_boxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="473" mass="53510" checksum="1E64E38FCE827010" modified="2021-04-07" version="1">MSPAIDYGEKIPNNVDLAGDRRLQRALESWQPNFLQWWKEMGPVVPTRDVYLRTAVDVGRDGWAHFAHVPMDQYRWGIFLAERRGDRRIAFGAHQGEPAWQQVPGEYRAELRRLLVVQGDTEPASVEQQRRLGLTAPSLYDLRNLFQVNVEEGRHLWAMVYLLHAHFGREGREEAEELLHRNSGSAEAPRILGAFNEETPDWLSFFMFTYFTDRDGKYQLGTLKESAFDPLARTCDFMLKEEAHHMFVGTTGVDRVVERTARLMVEHDTDDVGPHGGIPLDVIQKYLNFHYSVSLDLFGGETSTNVANYYTAGLKGRWGEEGRDDDHRLTDATIEVDALGEDGTVGRVEAPALVGLNTDLRRQYIADCEKGVARWNRVLEQAGVTGRLRLPSVAFNRRVGAFAAVEATPDGRVVGADEFERCKDAWLPTGADREHVRSLMQPVYEEGRIASWLAPPKQGIDGKPFAFDYVHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM7</accession>
    <name>A0A7K0JRM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000336">
        <property type="protein sequence ID" value="MST32591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="356" mass="36227" checksum="97E3FACD10B150C9" modified="2021-04-07" version="1" fragment="single">MTPDVLIVGAGVIGASTAFHLARAGVAVDVVERAAVGAGMSSRSSALIRMHYTFPPEVELAVRSDTMFDAWPELVGRPAFVRRTGFVRIVRPGEEDQLRANVAAMQGLGADVELVDGASLAALAPGMRTDDVTLAAWEPHGGFGDGALVAGDFLAAARAAGAGYHPGTMVTGLVRDGQRVVGVSTPGGVLPAGTVVIAANVWSPLILRSIGVELPIETELHRVAHLRHAPGTGAPVAVIDSATATYFRPEGTGFDRTLVGDEFSGKRGVDPDEVPPSGPADLVPDIVEAAARRVPGLADAGITGATTGVLDMTPDGRPLLGPLPGWEGLVLATGLSGTGFKVSPAIGEAVAAQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS9</accession>
    <name>A0A7K0JRS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000262">
        <property type="protein sequence ID" value="MST32279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="15821" checksum="9845EC14E9D34C7A" modified="2021-04-07" version="1">MRDPGDVFHLAIPARDLDETQRFYVDGLGCHLARRYDDRITLDFFGDQVVCHLSDRWERDPGDLYPRHFGVTFRRREDFDALVRLAEARGLDVYAPVGHRFEGRVEEHLTFVLRDPSNNLLEFKHYFDPRMMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU0</accession>
    <name>A0A7K0JRU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="12577" checksum="F75F825144FDA034" modified="2021-04-07" version="1">MSRQPAPATRRCAQPDCPNPVIRPARRGRPPIYCSPTCRAQAKRRPPTRPVLVEIDHDPPNSQHRPAGRVWLVRLRRGPRTVTVASGLGHTSAESLAAQITAILRTPSATPGAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV2</accession>
    <name>A0A7K0JRV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000265">
        <property type="protein sequence ID" value="MST32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="197"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="383" mass="39985" checksum="9DD7DCA5EA2E8C62" modified="2021-04-07" version="1">MTEAACVEPADTGWVSQQRRWASGWRRTVFPAVFLLYLAETAGAVAQYNRAAGEVAGFLVLAAFCAAYVVALTRDTFTARAPTFWAIFAVQVACLAAELPLAHGAAFVMAVFIVVLAVGRLHARAAPIVVAFTAGAVLLPAAVPSWHQGPASGAAVGTAFAIPMVALAMFSFFNVLRGNVALAQARSEVSRLAAENERIRIARDLHDLLGHSLTTIIVKAELARRLAATDAGAAAAEIAEVEALTRAALADVRAAVSRYREPTVAGELATGRELLHAAGITADLPRSVDGIDERGRELFAWVLREGLTNVVRHAHASTCTVTLTADAVQIDDDGTGGDLGATGSGLSGLRERVDAAGGTIEAGPSPSGGWRLRVALTPEHALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV7</accession>
    <name>A0A7K0JRV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uronate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="6" type="ORF">GHK86_08040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000356">
        <property type="protein sequence ID" value="MST32670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="473" mass="52604" checksum="B1964F6C853DF0CC" modified="2021-04-07" version="1">MPTATTAPELHPDRLLPPDPAERAIARRLYQRVRDLPILSPHGHVDPDLLLHDQPFTDPAGLLVTPDHYVTRLLHADGVGLDELGVGAGALSEGAARRAWRQVCEHWSVFRGTPVRYWLEAELVEIFGVTDRPSAATADRMFDRIAERLAEPSFRPRALFERFRIQVLATTDDPCSDLASHAALDADPAWQGRVIPTFRPDRYLEPSRPGWPAAVRRLGAAAETDTGDYDGYLRALEARRRYFAEHGATSTDHAHVDARSEPLAPAEARRIYRSALAGDATPAEATAFRRHMLSEMARMACDDGLVMTLHCGVRRDHHPATAERYGPDVGADIPVRAELTDALRPLLSRYGTHPGFHLVVFTVDETVWSRELAPLAGFYPSVYVGVPWWFLDAPDAIRRFREAVTETVGFGRTSGFVDDTRAFCSIPARHDMSRRLDAGYLARLVADHRLGEDEAAEIATDLVEAQPARVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRV9</accession>
    <name>A0A7K0JRV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2088 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000356">
        <property type="protein sequence ID" value="MST32671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="426" mass="45032" checksum="09045C8C937E2FDE" modified="2021-04-07" version="1">MATTGLPAGTAARVGGPDGVVGRDVVASFVGEQLAAAPLDGRSLCVLVPDGTRSCPLPLLLQAVHAAVHRRVSRLTVLVALGTHAPMGETARAAHLGHPPGGLASRYPRTRVIEHAWWDPATFARLGVIGPERVAALSGGLLAEGVEVRVNRAVVDHDVVLVVGPVLPHEVVGFSGGNKYLFPGVGGPELIDLSHWLGALITSSAVIGTLGVTPVRALIDEAAAMVPSERLALCVVPVPGGDGLHALTFGEPEPAWHAAAEVSARTHVRYLDAPVRRVLSMVPERYDDLWTGAKGFYKVEPVVTDGGQVVLYAPHITRISATHPGIRDIGYHCRDYFVGQWERFRDHPWGELAHSTHLRGAGRWDAVHGERPRVTVTLATGIPAEEVAAVGLDHLEPGSVDPARWAAEPGTLVVADAGEELYRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS32</accession>
    <name>A0A7K0JS32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000381">
        <property type="protein sequence ID" value="MST32758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="47"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="381" mass="41027" checksum="910D95D2162D4DAF" modified="2021-04-07" version="1">MEDMLSSERLIGRPVTNPVATSTARARSGAQGAWPSSNRRASTEPIVQVQSVSKTYEPSPLWLRFLLRSAVKEPVKALTDVSFALSPGTICAIVGPNGAGKSTLFRVLTGLTTASEGTAVVGGVDVAHDPLEVRRMIGFVPAGDQTLYLRLSCVENLVFHGRLQGYAGNNLRRRIRQVLDQVGLGHASERVGFALSAGMRARLLLARALLHRPRLLILDEPTAAVDPVGSHELLEVIQEIVTSDAVSVLLSSHRLEEIEALQDQVAVLNRGELVYHGDLGAFREQYSQRLVELRFANDAARAEAQHVIESTPLLHLAECRADRALLVAGAQSTGALLQLLAANLTDITAITEHPVPLRDILRQLATGERVGGTQSIRGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS58</accession>
    <name>A0A7K0JS58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycofactocin system transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mftR</name>
        <name evidence="4" type="ORF">GHK86_06655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023851">
        <property type="entry name" value="Tscrpt_reg_TetR-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03968">
        <property type="entry name" value="mycofact_TetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="23106" checksum="4DBC90531B806BC7" modified="2021-04-07" version="1" fragment="single">MASESLPPRDRVDRAALDLFAQRGFDGVTAEEVADAAGISRRTFFRYYPTKADAVWGDFDGHVGRLATLLAATDADRPVLEGICSAYVEVNTYPAAEQARLRTRVALILTEPALQAHSQLRYAAVDGVVARHVGERVGRPASDLLPRLVATSTRAAATAAFEAWLNGAAPALDRALESAFAELAGGFPSLAGPTGTPRAGRRRGATPRGGDRPARAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG1</accession>
    <name>A0A7K0JSG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="12260" checksum="E0D826DE9A4A19D5" modified="2021-04-07" version="1">MGDELEKLIDGVGVGDGFRVSEDVFAAKRDRVGLVGSEVDGPAAAAGGEEDVIVSDVADGLMVTAAGASAGDRDEHERDPRGVGSGRPSSPRTGSLTRRISRARRRRPAGVGVVIVFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG2</accession>
    <name>A0A7K0JSG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000420">
        <property type="protein sequence ID" value="MST32886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="14741" checksum="1539A0447F9F64F6" modified="2021-04-07" version="1">MAADRADVRPGLQLGSLRRIRLRDYALRFVFGAVISVGAALIGQVGGPRLGGMFLAFPAILPAGLTLIQEKDGTRDADRTAVGAILGGIALCAFAIVGEAAFGTLPPWLVLLLALGAWCGAAIGLYALLAALRPEACDRNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI2</accession>
    <name>A0A7K0JSI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cation transport regulator ChaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000427">
        <property type="protein sequence ID" value="MST32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="SSF140376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="2">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14446" checksum="D555EBCCFAD82148" modified="2021-04-07" version="1">MPATLQRSPAKAQRTFAETLRSAEQEYGDEARARRTAYGAVKHGFEKVGDHWERKEGGRKGPSDAQSAQGGRQARDHPQESKGGVDANASKAHLYEKAKELGVEGRSKMSKGELVDALRRANARATRKARST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL9</accession>
    <name>A0A7K0JSL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein MoaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000437">
        <property type="protein sequence ID" value="MST32938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="19208" checksum="43FA9F49210F8B7E" modified="2021-04-07" version="1">MFPGEVIAPGRSRTPSWGFSIGAVSTPSRSDDWLDLSGEPLPVEEASRWVARPDCGAVVVFTGLVRDHAEGRPGVSSLEYEAYTEAVLPRMADLVAEARRRWELGRVACLHRVGRLAVGEPAVVVAVSSGHRAAAFEAARWCIDTLKESVPIWKRESWEGGEDWGTGAQPLSEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSM6</accession>
    <name>A0A7K0JSM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">GHK86_09490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000440">
        <property type="protein sequence ID" value="MST32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="18925" checksum="10CC4879590BFD08" modified="2021-04-07" version="1">MRSVAAGAEWVEAVIEIPRGSTNKYEYDHHRDVLLLDRHLFSATTYPADYGFVPDTLAEDGDPLDVLVILEEATFPGCHIRARPIGMFMMRDEHGPDCKIVAVPFGDPRWEPVRDLEGLPPGLTAEIGHFFDVYKDLEPEKWTEVGAFDGPAEAWDEIRKARSAFLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ0</accession>
    <name>A0A7K0JSQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C(20)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.130</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_09575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.130" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26261" checksum="FEFCB75241BF9D12" modified="2021-04-07" version="1">MTERRARGRLWGVGVGPGDPELVTVKAQRVIGASAAVAFFAAAGRPSNARAAAASHLRPGQRELALYYPVTTELAAGAGYERLLTGFYDEAADRIAAVLDEGVDVAVLCEGDPLFYGSYMYIHNRLASRYRSEVVPGVPSILAGAAVLGAPLVCRNEMLCVLSGVLPAEELQRRLAAAEAAVVMKLGRNLEKVRGCVEAAGLLERAWYVERATMPEQRILPLAEADPARAPYFSIVVIPSAEAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT30</accession>
    <name>A0A7K0JT30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000482">
        <property type="protein sequence ID" value="MST33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="363" mass="39625" checksum="97EFF6D01C0A92B5" modified="2021-04-07" version="1" fragment="single">MALDVRLIASEERKAWERSVGVPFLHPAADDPADDEQHWDQAPLDRTWAAVDGDRFVGNAAVFPRHVNLPGPAGGPCPVVPMAAITAVGVHPTHRRRGLLRRLMQAMLEDAVRRGEGVAGLQASEAAIYGRFGFGVATFAAARRIDPRRGAFLRPAPATQVRMLEPEEAEKVLPELFARTIAGTPGQVDRTDGAWRYDVFQDLPAWRRGRSANFYAASDEGYVQYRSERTPDGARLHVRDVCATSPDAEAGLWRFLLDIDLVGEIVAHHRPVVEPLAFRLADPRALETTGVEDFLWLRVLDPAAMLSRRSYRAAGRLVLDVAAADAPLLDPDPAVGRWVLDAGPDGATCRAATASEPADLRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT43</accession>
    <name>A0A7K0JT43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000484">
        <property type="protein sequence ID" value="MST33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="2">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="30036" checksum="6E7A2CE3AB7B7C15" modified="2021-04-07" version="1">MTAPAPTVSNDLKKLLRAVKLGRCLDTLPERLALAGQRDLSHHEFLELVLADEVTRRETSSATLRARTAGLDADMTLENWDPTTKVTYDHHVFDELASLRFVDAGHNALILGPVGVGKTFLATALGHAAVRRRYSVTFCRADILLKRLRASRLDNSHDTEIRKLLRVDLLILDDFALQPFDTLDTADLYELIVERHRVASTVVTSNREPVEWLAQMADPLLAQSAIDRLQSAAYELVLDGESYRRRQKPGLDTGTINPRPRRKRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT59</accession>
    <name>A0A7K0JT59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TraR/DksA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_08240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000366">
        <property type="protein sequence ID" value="MST32709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="11132" checksum="B785A2FE8D635E3E" modified="2021-04-07" version="1">MLADERAHLERLLAEVGRRDVVREAGDEHADRDDGAQPLTAEEADEAVASGLRNRLAAISRAEARLEAGTYGRSVKSGDLIPDERLEADPAAELTVEEAAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD1</accession>
    <name>A0A7K0JTD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000510">
        <property type="protein sequence ID" value="MST33187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="15574" checksum="C1BF1E2A6145EB71" modified="2021-04-07" version="1">PAAAAVMSPWADLTGDADSLRSRADLDASLTREALAVRAADYLAGADPRDPYASPARADLSDLPPLLVQVGTAEILLDDALHLAARAARDDVSVTLETFPAAPHVFQGFAAVLDEGRDALDRLGAFIRTHLDTPNPSATPPVAPVPSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI3</accession>
    <name>A0A7K0JTI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="52" mass="5605" checksum="062C31C747DE6AB1" modified="2021-04-07" version="1">MGQHVVGEDACRGFGVGLPRLAARGFPLSGFGEVIYHPLRQLVVVLSVRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ9</accession>
    <name>A0A7K0JTJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protocatechuate 3,4-dioxygenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000538">
        <property type="protein sequence ID" value="MST33268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="42" mass="4603" checksum="E9C66B25F47AAFC5" modified="2021-04-07" version="1" fragment="single">MSTDWERYGIAPQRSALPDPTGPTPSQTVGPYYEIGMSWMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV7</accession>
    <name>A0A7K0JTV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_09920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000463">
        <property type="protein sequence ID" value="MST33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="107"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1037" mass="102766" checksum="BCC810F0426A11EE" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ6</accession>
    <name>A0A7K0JTZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000450">
        <property type="protein sequence ID" value="MST32999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="172"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="394" mass="41600" checksum="E734540D378E77FA" modified="2021-04-07" version="1">MSPPSPDLAALLDRLDTVAPSDLGPALAAYLAESHGAAGSELWLVSHDWAALRAVGSGEAADPALIRVGSSSPLAAVWRTQQPAVTPVPGGSLAHLPVTYRGERLGVLQVELAAPPTDGELAELGRVARTAAGRVLLDGRYADRYERVRRLQPFNLPAELQSVLLPARGCHTAHFTLAAQVIPAARVGGDHFDYQIHPDGVTVTVSDAMGHGLDAAMVTTLGVGALRHARRHRQPPAEQFGAANDALHERFGGEKFMTALMVHVGGEGALVVQAGHPNVTRVRGGHAAPLDFRPQLPLGLFPTSRYEAQAVDLAAGDRLVLVSDGTLEAVDGDGEQFAERSFARILTETAGEDPHATVAALQQALLDHQTGDLRDDATIVCLDWHPTWERGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU31</accession>
    <name>A0A7K0JU31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000602">
        <property type="protein sequence ID" value="MST33455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="227" mass="24178" checksum="1068589A6318C99C" modified="2021-04-07" version="1">MDYTAGLREDAAAGARIGVVAPADLADGDRPAWEDAQEAFRSLGAELVPVTLAGSSPSIFVLDYEFGPALAAYLAALGPAAPVRTLGEVVAFNRSRAGEELKFGQARLEAALAVDHGDPAVRDRYREARADDLAFGRDEVDRALAGDRLEALLFVNETSCDRGARAGYPSVGVPAGYSTTHRRPVGVTLLGPAWSEARLLALAYAFEQATRARRPPSAVNPAQFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU56</accession>
    <name>A0A7K0JU56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000606">
        <property type="protein sequence ID" value="MST33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="10548" checksum="3338F9903505FA68" modified="2021-04-07" version="1">MTTGAVTVEDLENHRRELSGYCHRVLGSASEAEDAVQETMLRAWRASGRFEGRSSVRTWLYRIATNICLDEQRSGRRRAHPVDPGPAPPGDEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU73</accession>
    <name>A0A7K0JU73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_10435</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000497">
        <property type="protein sequence ID" value="MST33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="13">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="12">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="11">
        <location>
            <begin position="329"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="446" mass="47769" checksum="FD089B8C44475C7B" modified="2021-04-07" version="1">MPWPAVARWTSPAPFGPPTQPGTLRRRPYQEAGPPRGPARAGSRKGERREIRAIRFSRPIDGADAAPRARRRGPGPTIDCHGWQGEAHATECPLPSRSGGAPPGTVALSGGTAGAQARLSGRRKCAVALTALGVEGATEVLRLMSAAEVDELTAALVEVGSVTVMERDLVMGTMDRSLLARRPVDGTRFARQALVGALGSEEATAVLNRVASPTLPRFDVLARLEPAEIARLLAGQGHQVAAVVLAHLPADLAGVVLAELPAEHRPAVIERLVDLRNVPDQVLDQLEASIAAALGDLPEARADGVDGVALVVEMIARGGRQVERVLIDDLEKLDPELAARVRDSMFMFEDLMKLADRDLQTLLREVDRKDLTMALRGVKPAFQTRIFDNVSSRLRGAIEEDLEGLGPQPRKEVEAARASIVSATRQLADQGKINIFYGADEGEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU98</accession>
    <name>A0A7K0JU98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF559 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000625">
        <property type="protein sequence ID" value="MST33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="2">
        <location>
            <begin position="188"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="611" mass="68272" checksum="2623245F299425C5" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA0</accession>
    <name>A0A7K0JUA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000627">
        <property type="protein sequence ID" value="MST33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="16369" checksum="4BBEEB73B07DBE51" modified="2021-04-07" version="1">MESSAPLASQLRLAVLRLSRRLRQQAVDEITPSQLSALASVAKHGELSLGTLASLERIAPPSMTRIAARLEERGLVVRRSDDVDRRVARVAISPAGQAVLEQTRNRRDAYLAVRIQDLSEEEQELLARAVPLLERLAAESADLEAATPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB7</accession>
    <name>A0A7K0JUB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7023" checksum="71F1F0C7E08E1E1C" modified="2021-04-07" version="1">MRVVLRNPDREVEMAGPLGVRTLLERLGINRESVLVIADGTLVTGDAQLGDDVRVEVRPVISGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE8</accession>
    <name>A0A7K0JUE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000637">
        <property type="protein sequence ID" value="MST33561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26944" checksum="364C91AC192595E2" modified="2021-04-07" version="1">MWSGPRTLSTALMRSFGSRADTVVVDEPLYAFYLQRTGLEHPGRTEILATQATDWRSVVAGLTTAPLPTGTRVHYQKHMTHHLLDEVDRSCLAGLRHAHLIREPRSLVASYARVRAEPTLADLGLVQQVELYERFGGPVLDAADLRRDPEGALRALCAALDLGWDPAMLSWAAGPRPTDGVWARYWYASVEASTGFRPPGHDAAAGGAEAATEPLPPPLARLVEVCQPLFERLRTARLTIHTPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF3</accession>
    <name>A0A7K0JUF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000521">
        <property type="protein sequence ID" value="MST33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="PTHR10363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="45069" checksum="84EA01ECBCF54A15" modified="2021-04-07" version="1" fragment="single">MDTTLDAAALEAMRKDFSASPTYRLTQNAVTRVALADVALDREVVNTTDHAISTLLDDWKVTNQQHSGRCWLFAGLNLLRVGAMQAMNLKDFEFSQNWMMFWDKLERANYFLEAIIETADRDLDERTVARLLDTPAEDGGQWNMFVALVRKHGLVPKPFMPETKSCADTREMNQILRSLLRQGAKTLRAATAGGGVGAARAEKAEILRVVHRVLCIHLGTPPEQFDWQWTDKDRVFHRDGVLTPQEFAARYVALPLADYVCLVHDPRPSSPIGRTFTVEYLGNVLGAPPVTYLNVDVPLLKELAARTIQGGEPVWFGCDVAKMMSDEYGIWDARLHDFGAVYDTAFTLDKADRLLLHESQMTHAMLFTGVDVVDGTPRKWRVENSWGKDRGKDGFYTMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ4</accession>
    <name>A0A7K0JUZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="25193" checksum="2169C02E714D9BA0" modified="2021-04-07" version="1">MEYFFDPMCPWAYRTSRWIREVRRHVELDVTWRFFSLEEVNREDGKKHPWERAWSYGWSQMRVAALLRRDGAEAVDRWYAATGAAFFERGLPTFTPDGARAVLESIGVDPLRVDEALDDPTTGDEVLADHRACVERHGGHGVPTLVLDDGTALFGPVVLDPPEGQEAVRLWELVTAWRDFPTLFELRRPKTDAHVAAIGDAFRPYLDTRAWRTVERPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV03</accession>
    <name>A0A7K0JV03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000726">
        <property type="protein sequence ID" value="MST33790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="249"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="611" mass="66176" checksum="3E8A25BE23CF38FB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD3</accession>
    <name>A0A7K0JVD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance/dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000766">
        <property type="protein sequence ID" value="MST33903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14449" checksum="E5B92FE40570280C" modified="2021-04-07" version="1">MARVQLAINVPDLEQAIAFYSKLFGTGPAKVRPGYANFAVVDPPLKMVLIEDAGHTPGSLNHLGVEVASTEEVAAAQARLAGEGLATAVEAGTTCCYALQDKVWVEGPGGEPWEIYTVLADADAPVTPGRPTVPGTGACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD4</accession>
    <name>A0A7K0JVD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000766">
        <property type="protein sequence ID" value="MST33901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="231" mass="23782" checksum="790C034D52844C70" modified="2021-04-07" version="1" fragment="single">MHLLAVGGSDAAISAALRARELDPGAEVTVVVADAYPNFSICGIPYLISGEVSHWRDLAHRSIGDLEAAGLRLRLGTVATRIDAPGHRVTLRTPGGAEEGITYDALVVGTGARPVVPPIDGLHGPAALGPADGVHLLHTMEDTFALTATLEGHRPSKALIVGAGYVGLEMADGLRSRGLAVVQVERLPEVLPTVDADLGALVRAELTARGVEVATATTVRAIRRAPAGAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM0</accession>
    <name>A0A7K0JVM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYZ2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000801">
        <property type="protein sequence ID" value="MST33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYZ2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="18175" checksum="25BDA7CB8DFE9174" modified="2021-04-07" version="1">MLGRPALDARQLAGWFTASGYVAATQASIAQLARWYIEEGDAEGVRGDLAFAQAVLETGGFASPDAVMQHNFAGIGHCNSCATGWKFPNDRLGVRAQIQLLRTYAQPGLTAAQLANPPVVPGLDPSRQYVEGCCSTWPSLTGVWATDPLYGRSILLVYQSMLAWALSSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM1</accession>
    <name>A0A7K0JVM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">GHK86_12845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000658">
        <property type="protein sequence ID" value="MST33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="20251" checksum="FC21E3AF14A798D6" modified="2021-04-07" version="1">MATRAVRLFGDPVLRQQASEVVDFDAQLRHLVADLHDTLYDQDGAGLAATQVGVLQRVFVWHGADGEEGHLVNPVLEFPDEELQDGPEGCLSIPGLYFDTKRRLNTIAKGYDVHGRPLQVVGEGRMARVLQHETDHLDGVLFIDHLDPDARKEAKRAIREAEWNQPPEIRVSPHRVRGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM4</accession>
    <name>A0A7K0JVM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA integrity scanning protein DisA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000803">
        <property type="protein sequence ID" value="MST34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="9270" checksum="8215976BF8D4A898" modified="2021-04-07" version="1" fragment="single">MLAALRAVAPGRPLREGLDRILQANKGAIIVVGDGPDVLAICSGGFLLDAEFSPQRVSELTKMDGAIILAGDASRIARANVHLVPNPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP4</accession>
    <name>A0A7K0JVP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hisC</name>
        <name evidence="5" type="ORF">GHK86_14975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000814">
        <property type="protein sequence ID" value="MST34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="354" mass="37835" checksum="95679829E1227037" modified="2021-04-07" version="1">MSRLPDARADLGLREGYHSAQVDAEVRLNTNESPFPPPAEWREALAAAVGDIAWERYPDRAVGALRAAIADQHGVRPDQVFAANGSNEVLQSLCLAYGGAGRTALTFEPTYALHAHIAHLTGTTVASERRGRDFGLDPGAVADAVRRHDPVLTFLCSPNNPTGTVDDPAVLDAALAAASGLVVVDEAYGQFAERSALARVDDDTPLVVVRTFSKTWSLAALRLGYAIAPAPVVQLLERVALPYHLDACKQVAGRLAVAHEAAMQERVAALVAERARLLAGLAALPVTVWPSQANFVLFRPEGRDGREVWKGLLHRSVLVRDTSSWPGLEGCLRVTVGTPAEDDRFLAALAEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP7</accession>
    <name>A0A7K0JVP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000815">
        <property type="protein sequence ID" value="MST34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="134" mass="13795" checksum="6A04F098CF4199EA" modified="2021-04-07" version="1" fragment="single">VALVEDHALLSAALSAALTAEDFRVAIPAHTSLDAVLGELLRQGPLVALLDLDLGPLGNGVDLVAPLAAAGCRPVIVSGSSDDWEIGRCLELGAAGWVAKTAGIDELLAAVQAAAEGRPVIAEQTRTRLQEAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW5</accession>
    <name>A0A7K0JVW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000687">
        <property type="protein sequence ID" value="MST33679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="463" mass="50291" checksum="326E310EA73DBB0A" modified="2021-04-07" version="1">MTVISGGGMALLNPPTAGPDCSFAARRSFWFCCRGCFPNLEARKRVRALGRLVRTPRRTCSSVGPASYTLDGHQHEQEGCELGPLPGGNAQVADTREEDDPDKREDEGGKQVGPPQTGPEDLAEPAAPDRSLQLERGDLKHGSLASTGITGSGGGGPGPPVPMTRLLTRRQLAPAARLRRPGHHDLCHHRPERARCAAAPRRVGLSAHGGARHVRQVTYTGLTNDSGSRQAYERSADVAPSDPAAVSSFVVRRDMFARRDAAIRRELLRVAPALTLDVGCGGLRRGGDLVQGRPYLCTDIRSDVPIDFRSSAFNLPVATSSVEAVLALEVLEHVTDPARVLSEAARVLTGGGIAIVSVPSSVPRHDSHDYWRFTAEGLLELATPFFKECKVEVFGGTFETLAALAEYYWALVAHRTWWPLRHATRPLLGMARRLDDRFEWATDAEALHTLAFDLLLVARFPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ8</accession>
    <name>A0A7K0JVZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000857">
        <property type="protein sequence ID" value="MST34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="299" mass="31994" checksum="A549C52BE22C0793" modified="2021-04-07" version="1">LATAFPSPAGVTAVVATWNARTPPEDATALLEDAGNSLRLALEREAAERAHQEAITLRRSQELQRQFLSRLSHELRTPLTAIRGYASSLMQPDVTWERDDQQRFLGRIAAESSRLGRLVGDLLDFSAIEASVLRLQPDWCDLPLVVDAAAACVVTPPGTLLEADCEPGLPPVWADHDRLEQVLVNLLDNAVHHNPPGTHVRVAAALEGGQVVVSVADDGIGAPADLLATPIGSPPERRSRTAGAGLGLSIARGIVAAHGWQLRLLRPAKGTVLRIAIPVERLTDPDTELDDDRPVASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW42</accession>
    <name>A0A7K0JW42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rdgB</name>
        <name evidence="8" type="ORF">GHK86_15780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000884">
        <property type="protein sequence ID" value="MST34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="207" mass="21478" checksum="F496C95CA0BE70B2" modified="2021-04-07" version="1">MSEPPQLVLATANPDKAREIAEILDGLVRLVPRPDGLGEVDETGDTLEDNARLKAVAVSARAGAPAVADDTGLEVDALGGAPGVWSARYAGPGATYGDNVRKLLDALEGVPPEQRTARFRTVALARWPDGAEVLGVGVVEGVITTHPRGAGGFGYDPVFSPTEGDGRTFAEMPAADKHRLSHRGRAFADLAAQLGSRPTRLAGGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW53</accession>
    <name>A0A7K0JW53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000890">
        <property type="protein sequence ID" value="MST34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="23348" checksum="E8F5CA85A6430712" modified="2021-04-07" version="1">MTTGGRPRVVLVDDHRLFRAGVRSELGDRVEVLGEAGDVAEAVEVITASGPDVVILDVHLPSGGGQAVVEEVKRTDPSVRFLALSVSDAPEDVIAVIRAGARGYVTKNIAGDELVEAVQRVAGGDAVFSPRLAGFVLDAFAALPDEAPPVDPELDQLSAREREVLRLIARGYTYKEVARELSISAKTVESHVSAVLRKLQLSTRHQLSRWAAERRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC5</accession>
    <name>A0A7K0JWC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000917">
        <property type="protein sequence ID" value="MST34255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="24297" checksum="7F8E9A39BA1A2D29" modified="2021-04-07" version="1">MQPILPQPEASIAPFDDEEYEEQCLVSSFWTASRLLVIVGIFLFGTFVFAYFYLRALNSSHAWRVHHQHPSMIIGTMVAVCVVLAALVHYVGARRLQIGSLWDWQVSSLVSLIVTAIAAGLQVWEMTRLPFSPASSGYTSVFVAWMPVYILFIIGQWFWLEILLARSVRAPEAVLAETEEGVLIVSRFGANVEGFVLFSEFMVVSAIAIWILFYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE2</accession>
    <name>A0A7K0JWE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000921">
        <property type="protein sequence ID" value="MST34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="12133" checksum="4B31F858475EE9FA" modified="2021-04-07" version="1">MSDASPSRPVGPYTPIVRSGGWLIVSGQLGLRDGALVDGGVEAQLTQAIANLAALLASEGADLGSVVKTTVFLTDIDDYPAMNAAYVAAFGEHRPARSAVAVAGLPLGGLVEIEAWASIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI8</accession>
    <name>A0A7K0JWI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ORF">GHK86_16465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000938">
        <property type="protein sequence ID" value="MST34308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14734" checksum="1C8F11F517718F02" modified="2021-04-07" version="1">PVSAARRHDPHRSSASPSRRYPRSARVNEVLREVLAEELERLSDGDARLGLLTITAVQADPDLRHATVLFATLDDQAAEAVEEVRVKLQAAVGRQVRLKRTPRLSFAADPAVASGQRIEDIIREIHRRDEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM1</accession>
    <name>A0A7K0JWM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000957">
        <property type="protein sequence ID" value="MST34347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="16668" checksum="E238D69386FDD028" modified="2021-04-07" version="1">RSDEPLSVVVVDLDHFKLINDVQGHQAGDEVLRTVARLLAGTVRASDTAARYGGEEFALVLPSCGVEGALRVAEAARSAVAGHPDLGGLTLSAGVATLDTWAPDAAGLVRAADAALYRSKRSGRDRVSVACPGDLDAVAEPAPEASLDLRERPTGPAPRPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR5</accession>
    <name>A0A7K0JWR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000802">
        <property type="protein sequence ID" value="MST33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14525" checksum="76AAE644D9A44F02" modified="2021-04-07" version="1" fragment="single">MAASVGLDRGTLRERWRPGRRTFGFGALACATAMAISACGSGSGAGTAASHTSGPAPVVKGTPVKGGVASYALPLGEDFSWMLPLQNEANYENYDGNVESGMWRPLFYAGGAGTTGINYGLSIGQKPVYSQGNTVVTVNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR7</accession>
    <name>A0A7K0JWR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000977">
        <property type="protein sequence ID" value="MST34388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="59"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="27478" checksum="A40F834316EDE30F" modified="2021-04-07" version="1" fragment="single">MQSARKAEVVTVGHALVDVLAPVEDAVVAGLGLEKGTMTLVDGARSEAILSALRPETAVSGGSAANTAVGVAALGGAAGFIGKVRDDEWGRHFAADIRAAGVHYAVPVAADGLPTGHAVVLVTPDGEKTMCTSLGIGDLLAPDDVDRDLVGGASIVYLEGYLCGLPHTEATVLTTLEAAEEAGTAVALSLSDPLWVRLHREELAALLPRVQLLFANGEEACRMVGVEDPHAAAEALGRRCGTVVVTLGAAGSLVVGGDRVDAVPAVELTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX74</accession>
    <name>A0A7K0JX74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001063">
        <property type="protein sequence ID" value="MST34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="828" mass="89578" checksum="8B1B05CE3A2E52FE" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX93</accession>
    <name>A0A7K0JX93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001072">
        <property type="protein sequence ID" value="MST34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="52"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="477" mass="52280" checksum="5F7C089CDCCEDF34" modified="2021-04-07" version="1">PKRGGRLTAGLTGGSSSDTLDAQQGVNNVDFSRLLQLYNPLVAYDSQVRPTLALAEEFTPNSTATQWTVRVKKGITFHDGKPLTADDVLFSITRIVKGKLPGSSMLPALDLAAMKKLDTYTVLLPFHTPYASVMEAMAGYSYYLNIVPVGYDPKHPVGTGPFKYQSFTPGVQSVFVRNPDYWEHGLPYLDEVVVVDYADANSQLNALQSGQADVINLLSADVIGTVESSGAKTVVSPGGGFTPFTMRVDQAPFNDVRVRQAFRLIANRPQMNSVVFEGHGVLGNDIFSIYDPEYDRGIAQREQDIAQAKSLLRSAGQDGLTVELVTSDIAQGTLGVAQVFAQQAAAANVKVNLRQVNVTEFYGSNYLKWTFAQDYWYFSDYLPQVGQATLPTSPFNETHFDNARYNALYQEAVATLDKAKQAEITHEMQHIDWTEGGYIIPYFPPVIDGHAAKVQGVLPGKTGLSLNAYGFKSMWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB6</accession>
    <name>A0A7K0JXB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001088">
        <property type="protein sequence ID" value="MST34593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="199" mass="20269" checksum="E128651E97EFFE86" modified="2021-04-07" version="1" fragment="single">MLLSAVASAPSGLTLYCFSVGLVAAVNPCGFPMLPAYLTLSSSDEATTPLPVRVVRALGSGAAVTLGFVVVFTLIGVLAKAGASVAFGWLPWVMVPIGVACFAIGLWTVVGRALKLPVPSRRLFAGRRRGVALFGFGVTYAVASLACAFPLFLGPVVGSFAQRGVLAGLLDGLAYALGMGLVICAVSLAGVGAQQLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF6</accession>
    <name>A0A7K0JXF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001115">
        <property type="protein sequence ID" value="MST34630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="33"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="340" mass="35035" checksum="1647A1F7EB3113FF" modified="2021-04-07" version="1" fragment="single">MVGVISTAGAAAAPGRRIAYLLPDPGIPVGGVKGASVHVDGLCCALAQLGYEVTLYAPRVVGPLWGPEAHRVTVVPVNVGDVRSGIDADVSRMTAASRFFPAVEAALAASRPDWVHERLSLFAGEGAAMAARLGLPRVVEVNAPVAAERETHFGLTAREEAAAAERAALEGAAVVAVSEPLAVWAESMGAARATVVPNGATLDPLGPLGRAEARTRHRRAFGFDDGVVVVGFAGSLKPWHGVEVLVDAVGRASAHHELALLVVGDGPARPRIERAIAGLPDTARVVMAGAVPARTVAEYLAAMDLAAAPYLPSESFYFSPLKVAEAMACHLPVVASDFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG2</accession>
    <name>A0A7K0JXG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein insertion efficiency factor YidD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidD</name>
        <name evidence="1" type="ORF">GHK86_17820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001074">
        <property type="protein sequence ID" value="MST34572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="6981" checksum="DE43705D59649AED" modified="2021-04-07" version="1">MALIRGYQVARAGRVSLCRFTPSCSQYALEAIDRHGARRGIVLAARRLARCRPGGPFGLDPVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM9</accession>
    <name>A0A7K0JXM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001169">
        <property type="protein sequence ID" value="MST34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="48" mass="5315" checksum="86C757BD7C9F1453" modified="2021-04-07" version="1" fragment="single">MPSSDPLLERHLTAWLGAWPPPDGRVEVVASPRRDEPGWDGRIRPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR8</accession>
    <name>A0A7K0JXR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001191">
        <property type="protein sequence ID" value="MST34746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7925" checksum="B5973E81146BB95D" modified="2021-04-07" version="1">MLVFDLVAGLVITGVVLAVLFIGIAQSGRYQAELEVQRDRGVVTPGRFGQEELDEAVRRVVRTRRDERRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY37</accession>
    <name>A0A7K0JY37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1206 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001259">
        <property type="protein sequence ID" value="MST34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="3">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="23994" checksum="04CD779AB1EC76FF" modified="2021-04-07" version="1" fragment="single">MRTPRSRPPRRWRVRQLRTGAGPRPRLRPSPCSVPRPSSSLERDARRNIPDRLAGAPSPAQGARRVPSAVCRRGWRGTPHPVTQATATVRLPQRSAPVRVLARLGIASRGLVYLLLGWLVLSIVVGGRRHQASDKGAFQTVAAQPGGKAILLVLAVGFGCFALWAASQVLTRSARSHGAGALARRVGAAGQAVVYGFLCYLAAAFVVGAGSGSGSGDPAPLAAAVMRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY45</accession>
    <name>A0A7K0JY45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Citryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001275">
        <property type="protein sequence ID" value="MST34883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15115" checksum="9A34A8C658CC8DAC" modified="2021-04-07" version="1" fragment="single">MSADDLSFPTSLGTSSAEQIRLLGRDLTAELMGQVGFGELAFWLVTLRRPTPRETRLFEAVLVALADHGFTPTAIAARLTYLSAPDSLQGALAAGLLGGGSRFLGVTEDCGRFLHDALEQAGAGGGALPGDDAGWDALALEAVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY49</accession>
    <name>A0A7K0JY49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase Y family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001012">
        <property type="protein sequence ID" value="MST34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003314">
        <property type="entry name" value="Mu-type_HTH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51702">
        <property type="entry name" value="HTH_MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH Mu-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="290" mass="30063" checksum="D167EC0F3828418F" modified="2021-04-07" version="1" fragment="single">MGQGRSREFLAPLSVTALPDPALADLLVRLGIPTLGDLAALPAQAVLGRFGVAGDRAHRLAGGLDERPLTARVPPADLTVSIELDPPADRVDVAAFAARSLAAELHERLAARGLACTRVAVEAETEHGEHLCRLWRHEGALGPAAIAERVRWQLDGWLSQGGTTAGLILIRLVPDEVGPAGGRQLGFWGGAADHEGVARAFARVQGILGPEAVVTAVLGGGRGPLEEVRFVPWGEPRSPARPGPATGVEGMAVPTDHDGPVVDDAPEGDALAGSVARHPAARRPTPEVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY59</accession>
    <name>A0A7K0JY59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001271">
        <property type="protein sequence ID" value="MST34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16403" checksum="96325433219815F2" modified="2021-04-07" version="1" fragment="single">MAAERHWLTRAAHPGVVRLLPAEGSDALWLRDVGSRSLAALTPLEPAALCGLGAATATVLGDLHDLGIAHTAPTADHVLVDPDGRPVLCSFGRATRATPDAMALDVRLLADALAGAGGTGIPRRARKALERAGRCRRGYSARTLARELAAAVGEPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC9</accession>
    <name>A0A7K0JYC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="5" type="ORF">GHK86_19845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001332">
        <property type="protein sequence ID" value="MST34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="131" mass="14263" checksum="1DA57B681D45BEB7" modified="2021-04-07" version="1">MAAYPMPQAGRPPPGTLASVAHREGVAGPSGRVGDRTTRLRRPGRSERSRMDREQALATFRDCVAEVLDIEPSEVVLTARWREDLDADSLAVVEITLALNDAFSFKFPEVDPEQIKTVGQAFDLVCGLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYK7</accession>
    <name>A0A7K0JYK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001100">
        <property type="protein sequence ID" value="MST34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="24353" checksum="8E2FFA63B791313D" modified="2021-04-07" version="1" fragment="single">MGVLDPLDHDEVADALGRVGELRHRAARRRRRRRQGMLTGGVTVFAALIAVVVAVTASGSPASVSVTGPPHAGSPGRLVPVRKLVAMQMLSPQIGVGLVASSSTVDAASGPSARGVLQLAVTDDGARSWRLSGSPVVSIGKGSGLSPDPALPGGGMIAFTSTTSGYFEDSSGLYHTGNGGHTWTVVPPARYGPPGSKPTSVLASGNRVWVLSCPGPACKHPSIAVTTAGTAHWTHHPTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP9</accession>
    <name>A0A7K0JYP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001137">
        <property type="protein sequence ID" value="MST34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="10359" checksum="67B0AFE0080250D3" modified="2021-04-07" version="1" fragment="single">MLERRAAGEPLQYVLGSWGFRTLDLLVDRRVLIPRPETEVVVGVALELLAGRSQPVAADLGTGSGAIALSLVAEHPDVQVWATDASAEALDVARANAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX1</accession>
    <name>A0A7K0JYX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001481">
        <property type="protein sequence ID" value="MST35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="18471" checksum="D330663A7E4433E9" modified="2021-04-07" version="1">ELYRGSLIRVARGSFRAPDGSRFERDIVHHPGAVVVVPLAGPGTALLVRQYRAAIGTELLELPAGKRDVDGEPPERTAERELIEEVGRRAGKLELLAEFYNSPGFCDEHTWLYLATDLTEVPHDRQGVEEHAMTVHEVALGDLDRLVASGEVADAKTIVGLSLAARRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY0</accession>
    <name>A0A7K0JYY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_20695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001460">
        <property type="protein sequence ID" value="MST35137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="14572" checksum="F5DB7BCFB411B877" modified="2021-04-07" version="1" fragment="single">MHPDGAQLGISVFFVVSLATRVALTAGFELRRPKAAVGAIAALTVLGVGLLALGGSVPVLFVALAILGVPHGLVFPLALGLIAEETPPAKLARANAAFSAWTSGVTVVLPAVLGGLVAVAGLRAMFLALLVPVLALGALVAAWPTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ70</accession>
    <name>A0A7K0JZ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoxR family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001263">
        <property type="protein sequence ID" value="MST34864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="58" mass="6155" checksum="7626AC86AB0431B2" modified="2021-04-07" version="1" fragment="single">MTDAAPRFDSPADVRQALRRVDYLADDSIAGVVFLAERLGKPVLVEGPAGTGKTQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB4</accession>
    <name>A0A7K0JZB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar biosynthesis protein FlhF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001593">
        <property type="protein sequence ID" value="MST35296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="51" mass="5264" checksum="20353FBCF471142C" modified="2021-04-07" version="1" fragment="single">MEEAVEAARGALGPSARILAADRVRSGGVGGWFARERVEVTAEVDDAPGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC6</accession>
    <name>A0A7K0JZC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001309">
        <property type="protein sequence ID" value="MST34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="8322" checksum="A20D6421532B249F" modified="2021-04-07" version="1">MPLQSMLAEPTLRRVDAVAASGHDGARRLATYFVGQGVGMLDTVRPVRRVVEEMMEDFLLAVDRLHALTDAQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE7</accession>
    <name>A0A7K0JZE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIGR01777 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001645">
        <property type="protein sequence ID" value="MST35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="247"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="299" mass="32135" checksum="9BBBC732163546D1" modified="2021-04-07" version="1">MKVAVTGSHGLIGRRLLGELRSAGYEVVRLVRSAEGDAAARWDPEAGTVDVARLAGVEAVIHLAGVGIGDRRWNPDHKRAVLDSRIKGTTLIARTVAEMEPRPRVLLSASAIGFYGDRDDELLAETSPSGAGFLADVCRQWEAATAPAEAAGVRTVHLRTGIVQSRDGGALATQLPMFKLGLGARLGRGRQWVSWVSLDDEIRAIRHVLEDESVDGPVNLVGPAPVTNAEYTATLARVLGRPAVLVAPRPAVELALGREMAAELLFVSQRVEPAVLTRTGFSWRHPTLEEALRAELHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH0</accession>
    <name>A0A7K0JZH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001631">
        <property type="protein sequence ID" value="MST35327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14508" checksum="14D51E67F2B128F5" modified="2021-04-07" version="1">MQRPYRVVMAKPGLDGHDRGARVITRALREAGFEVIYTGLHQTPEQIVDTVLQEDADAVGMSILSGAHLTLMPRVVELLRRHDAGDVLVFGGGIIPDADIATLKAAGVAEIFTPGAPLGAITGWLEAALDARESAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZQ3</accession>
    <name>A0A7K0JZQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmB</name>
        <name evidence="5" type="ORF">GHK86_21800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001654">
        <property type="protein sequence ID" value="MST35352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="7231" checksum="34B37CEE7182A1BE" modified="2021-04-07" version="1">MASVCEVCGKHPSFGMSISHSHRRTKRRWNPNIQRVRALVNGSPRRLQVCTSCIRAGKVTKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZV5</accession>
    <name>A0A7K0JZV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001425">
        <property type="protein sequence ID" value="MST35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="5800" checksum="566C0B036B2C379E" modified="2021-04-07" version="1" fragment="single">MTTRDDAGRTITITCPSCGETSSLVVSDEGTPERAADAFCPKCDYPLFWARAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0I8</accession>
    <name>A0A7K0K0I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001603">
        <property type="protein sequence ID" value="MST35304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="16173" checksum="1322AB21ED0390FA" modified="2021-04-07" version="1" fragment="single">VLPLADDDSRTGGGEAGMTRLARDALAQPGVDRVFLLLGTNDLWFGATAAQVIAGYRDILAQAGAAGVPVIASTLLPRSSGGREVWTPAMEAARRAVNNWILHSGAFAAVIDLAEVVGDVYDGACRPDVMFPPYDSGDNLHPDTAGQVAMADAIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMC7</accession>
    <name>A0A7K0JMC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_00005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000001">
        <property type="protein sequence ID" value="MST31113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="323" mass="34515" checksum="6C3E378A9AAE390C" modified="2021-04-07" version="1" fragment="single">LWRIREDGAGLGSRTPAGAPAWPAWEDAAVPPAVLAPYLRDFTALLADHGLDGLLYGHFGDGCIHVRIDLPLAEHPRRLRPFLVEAATLVAGYGGSLSGEHGDGRARSELLPLMYSPAAIEAFGAFKALFDPDHLLNPGVLVDPAPVDTDLRRPLAGPVRRRPGGLALHADGGDFTTAVHRCVGVGKCRADNGSGGGFMCPSFLATGDEKDSTRGRARVLQEMANGSLVADGWRSPEVHEALDLCLACRACARDCPVSVDMAAYKAEVLHQTWKGRLRPRSHYSLGWLPLWLDLARRTGAARLADRLLRLPALAGAAKRVAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMP4</accession>
    <name>A0A7K0JMP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="309" mass="32602" checksum="AF54714D3C6B4161" modified="2021-04-07" version="1">MSVVLVTGAATGIGNLTAVTLARAGHTVYATMRDPAGRNAGHADRLAQLGADEHIDVRVVELDVSSQASAGRAVDTVLTDAGDLDVVIHNAGHLTVGYVESFTAEEIAHLIDVNTLGVQRVNRAALPHLRTRGQGTLLYVGSTTSITTPPFLGPYVVSKAAMDYLAVTTAYEVGQLGVETVIVMPGAFTHGTEHFPNASRPADTDGIAAAYRSLDPLVARNEEATSSLFTPGADADPQAVAEEITRILALPYGQRPFRAVVDFTNSDVETANQTVYDARADFVRRMGFGQLLDLATPATPVTPRRPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMQ5</accession>
    <name>A0A7K0JMQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">bact-PGI_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000021">
        <property type="protein sequence ID" value="MST31228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bact-PGI_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="33" mass="3601" checksum="554E9CBE3A467ECF" modified="2021-04-07" version="1">IFGDYVSLWLAAEAGVDPGPVEVLTELKRRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMS4</accession>
    <name>A0A7K0JMS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029532015" evidence="2">
        <location>
            <begin position="26"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="217"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="345" mass="34082" checksum="A60F496167B2E1F6" modified="2021-04-07" version="1">MKGVALVAAGVAVAFVVGLAVIAGGATGGTVTNAAVLSVAQLATRTCSVSGPVPGLGASQAANAGQIVSAALSASAENTRAAQIAVMTAMTESGLENLDHGDRDSLGLFQQRPSQGWGTPAQVMDPTYATDAFVKRLLALPGWQTLPPWVAAQAVQRSKYADGSNYQPNWTPAGAVLSAVLADGNTPGACGQGGGDLAGPPSGHGLPAGYAIPGGTPAKHAAVVAFALAQLGKPYVWAAAGPASFDCSGLTMAAWASVGVPLDHYTGDQQTEGQPATAATPVPGDLVLTPGSDSPGPGIAGHVGIYLGDSLVISAIDPQYGIAVQSWSTFVSGGLIAVRDPAPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMY7</accession>
    <name>A0A7K0JMY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000036">
        <property type="protein sequence ID" value="MST31315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13457" checksum="15F21CBBCE4C5818" modified="2021-04-07" version="1">MRRAVWLLVVSVVTVGILFLFVFPTRTLVEQRHEMAAIHRQLSALDAENASLRGKVAALHQPATIERIAGQEFGLVMSGQKAYAVLPAAGPPARHVATTHAPTAAGPAHRHWWRALELWRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN22</accession>
    <name>A0A7K0JN22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein GHK86_00965</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000034">
        <property type="protein sequence ID" value="MST31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20632" checksum="9FDFA534ED82DA44" modified="2021-04-07" version="1">MPEATLVGKLLVANPRLTDPNFDRTVVLVLVHGEDGALGVVINRPSDTDVVEALPQWADRAVAPARMFLGGPVSHDSVICLARVPVPAALEARAGDDVWRSVSGDLGTLDLDTDSDRLDDTVTDLRIFVGYAGWSGGQLEEELIAGGWWVLDSLPDDPFTPEPLELWHRVLHRQGGELALVALYPPDLSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN53</accession>
    <name>A0A7K0JN53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="29763" checksum="04FCE78B039FD7C4" modified="2021-04-07" version="1">MSRSMDRRVEAALEVLRGSPAEQVAADHGVDAAQVREWAQLFVEGGKLRLDGRMDPTSYEARDRFLTLIAHEFRTPLTIIGGWVETLRSADLPPTVTQSALSAIARQVGYLQRIARDALDAGAVARGQLRLVVGPVDLRGLLEGVIRSTQDAAVLRTERPVVVVGDAARLEQVAAEVIAHARRLAGDGPVCVEAAGGDVVATVEVSVAGKRLSFADAAVLFEPFERADTSIGTGLGLFLCRALLSAHGGEIGVRSDDAATVFWFRVPSAGPTEGPLVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN70</accession>
    <name>A0A7K0JN70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000064">
        <property type="protein sequence ID" value="MST31420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="30820" checksum="F92292C697808C14" modified="2021-04-07" version="1">MALTVRSHRVGGRLGRLGLLPALGLAAAVVGGCNLIGHSSSPTTSSLPSSTVPATTTTLPTTTTTLPVSGPQSSGPRTVLSPLGLNVRKAPSKSAPVEGTAAQGVVLTVLHYTSSNGGWLKVKGATATGWISAQPALSAPGEFRSYRSGAFRALYPTTWRVARLRGTSAAATQSTPGAAGVATARVLFRPTSGPGDIVVSAASGVRQLPDGRAGYGFARSSQVLVCGITAQMVVFRHAGGPPPTSAASSTPEPLTYLAQVRFAVTRQRALGLYADLPDLGRTLQIFDEFVAAVTFTAPRCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN82</accession>
    <name>A0A7K0JN82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000036">
        <property type="protein sequence ID" value="MST31311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="237" mass="24559" checksum="5AD76BE76F51E89A" modified="2021-04-07" version="1" fragment="single">MIPAPFEYQRAGSVDDALRLLEEGGEDAKLLAGGHSLLPLMKLRLAAPTLLVDIGRLRDLSYVRDGGDSLAIGALTRHRDVETDPLVREHAPILAHVAGQVGDPQVRHRGTIGGSIAHGDPASDLPAAALALGASFKAVGPGGERSIPAADFFRGFLETALQPGEILTEIVVPKATGAGWSFQKFNRRAQDWAIVGVAAVRNGSTGIGLVNMGSTPLRARAVEEALAGGASAEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE8</accession>
    <name>A0A7K0JNE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000061">
        <property type="protein sequence ID" value="MST31407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="40794" checksum="BB6E5CE929002615" modified="2021-04-07" version="1">MTRLASRPGRGWRDHAAGWLFCTPAGVLVIIFLVVPIALALWVSLSNWDGIGSPLSSGVHYVGASNYKAILTRPGLPQQDFGESLRNNFYYVLLVVPCQTALALALAIFVSRRKLLGRGFFRTSYYFPSVTSSVSIAIIFQFLFSSSGAVNSILGFIGIHGPQWFNDPSGVIHIVLRAVGIRHGPALLANHGLLGVSWWDWMAGPSVAMVALIILAIWTTSGTFMLIFLPALYNISEQIEDAAAVDGASAWQKFWRITVPLVRPTLFLVLTLGVIGTWQVFDSVFLISQGNPAGTTLTPAFLAYQASFSDQQWGQGAAIAFILFVLIVVLAGAQRWLLRERDRSAAGQRRNPLRRLRSRPPTAGTAALVPGAGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF1</accession>
    <name>A0A7K0JNF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbamate kinase</fullName>
            <ecNumber evidence="3">2.7.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.2" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000085">
        <property type="protein sequence ID" value="MST31502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="26049" checksum="1D25D5770E649A98" modified="2021-04-07" version="1" fragment="single">MRIVAALGGNALLQRRDRPDAVLQRHHVHDAVAALRPLAEEHELLVTHGNGPQVGVLALESAADGSLSSPYPFDVLGAETQGMIGYWLVQELGNAVPARPVAGLLTQTVVAGDDPAFGAPTKFVGPSYEEGEARRLAASADWVVRRDGERWRRVVPSPAPVAVVEADLIRSLLGDGVLVVCAGGGGVPVVRGPDGTLRGVEAVVDKDATASLLARELDADLLLVLTDVPAVSVDWGTPAARAIRSAVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK4</accession>
    <name>A0A7K0JNK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="19559" checksum="EE63B82BB50D7BE1" modified="2021-04-07" version="1">MRGRFVPARLRLLVAAYGVSLTGSSTLPIALTFTVLERRWPTSDIGLIMVATSLPLVLTLPMAGVAGDRVRRGALMVGADGARFVSQGALGLLLLGARPPFPLVFVLVGAVGVGDALFNPSLSALVPAIAPGEEQRANALLGVTASVATLAGPALGGLLVAAGRPPSWRGHAWAVRGHGGSSWRAAGSGPSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP7</accession>
    <name>A0A7K0JNP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000090">
        <property type="protein sequence ID" value="MST31533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="104"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="259" mass="28347" checksum="2933E546232E8574" modified="2021-04-07" version="1">MTAAEAPALPADLVAGLKRLKLAKVRAIAPEVLATARTQRWKPEEVLRVLVEAEIAARDDSMTRQRRHAAGFPIAKTFDEFNVSLSSVPQASFDYIASLEWIRAAENLCLVGPAGTGKSHLLVAAGHAAINAGLRVRYFAAANLVETLYRGVADNSVARQIDQLLRADLVIIDELGFAPLDLTGTQLLFRFVAAAYERRSLGIASHWPFDAWGRFLPEHTTAASLLDRLLHHAVVIVTEGDSYRMREARTRGGHHPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY5</accession>
    <name>A0A7K0JNY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_00820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000028">
        <property type="protein sequence ID" value="MST31274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035277">
        <property type="entry name" value="MalF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="323" mass="35125" checksum="D8905E398CB2A57E" modified="2021-04-07" version="1">MTTSFSTARRPDGSPPLSASARPSPRLRHHGGGPVAKRQRVGAALVAPSFLFVIVFVLFPLAYAVYISLTNWPLVGSYHFVGLQNYTSLGSNAVFVHAVWFTLLYTAIVTPAIFVLGYAMAMFVRKNRPGSTLIRTIFFLPYIVGLATESYMVVLDVQPRFGIVNVILSRLGLASIDTAWLIHTDLALAVTCVLVTWYASGLTMLLLVGGMQGVSTDVYEAASMDGATWWQRESRITLPLLRPTIALSLIISVIGSFLAFNQFYILTQGGPGTSTDTIVMWIYQVAFVQLHLGAATAMAIVLVIAVGLVSMVQFIMLRDPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP46</accession>
    <name>A0A7K0JP46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16952">
        <property type="entry name" value="Gln-synt_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="106"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="450" mass="49475" checksum="E086864B4CC3FCB8" modified="2021-04-07" version="1">METVVAQARDAGVTLIRFEYCDTSGVARAKSVHVSRLADKLVEGVGLTRAQMAINLLEQVVHIPGMEPVGEIRLVPDPETFRVLPWAPASASVLCDQLDHDRRDWGACPRSFLKSVIAEAADAGIHVEASFEDEYYLARREGQRWVPVDVPTHAPVISAIGHDLGADLMIETIVALEAQGLEVESAINEYGPGQQEIAIRHAPALAAADRQMQFRDTVRGVALSRGIYASFAGKPWPEEIGSGAHIHFSLWDADRQRNLLLDPTAERGFSRLGRQFVAGVAEHLPALVAFTTPNYNSFRRLQPSAWASATTAWGFDNKEAALRVCSPYLRREEQSLNVEFKASDPSANPYLALGMLIIAGLDGVAKGLDPGEPSEHDPARLDDDARRRGKVRPLPSSMKEALDALEADPVLINGMNDLLARCYLAIRRSEESAFSGADEDFELHHHFYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP82</accession>
    <name>A0A7K0JP82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylaspartate ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GHK86_03195</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12829"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:36986"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="4.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate ammonia-lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050096">
        <property type="term" value="F:methylaspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006395">
        <property type="entry name" value="Me_Asp_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022662">
        <property type="entry name" value="MeAsp_NH4-lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022665">
        <property type="entry name" value="MeAsp_NH4-lyase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07476">
        <property type="entry name" value="MAAL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05034">
        <property type="entry name" value="MAAL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017107">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00007">
        <property type="entry name" value="methylaspartate_ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01502">
        <property type="entry name" value="B_methylAsp_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAAL_N" evidence="13">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MAAL_C" evidence="14">
        <location>
            <begin position="160"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST31733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="413" mass="43863" checksum="9524B476E0101D95" modified="2021-04-07" version="1">MEIADVLCVPGLSGFFADDQAAIRAGAARDGFDYAGGPLTPGFDRIRQPGRSLSVMLVLDDGQVAVGDCATVQYAGAGGREAAFHAAAAKRLVEERVAPELVGRTVDSFRELDAAVFGLPGLPAAVRYGVSQALLDAAARARRTTMAEVVRDEWATGSALRPVPVFVQSGDDRYTNVDKMILKGVDVLPHGLINNVEDKLGADGGRFADYVGWVRDRILRLRADERYRPALHFDTYGTIGLAFGDETDRIARYLAGLVERAAPFTLRIEHPVDAGSRSAQVDAMVALRAALAEQGAPVQLVVDEWCNTLEDIEVFVAAHAADMVHVKTPDLGSIADTVTALLHVRDAGLLSYCGGTCNETDRSAQVCAQVAMACDADQVLAKPGMGVDEGLMIVVDEMARTAALAARRAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP96</accession>
    <name>A0A7K0JP96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000123">
        <property type="protein sequence ID" value="MST31717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005908">
        <property type="entry name" value="G1P_thy_trans_l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01208">
        <property type="entry name" value="rmlA_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="34323" checksum="21D180829E3E906A" modified="2021-04-07" version="1">VGDTAAEVEAAVGDGSAWGFDVTYIPQDAPRGLAHCVLIARDFLGDDDFVLYLGDNLLEQDLRSFVDRFEVARAAALAPPLTGAVEEPAAAQILLMQVPDPHQFGVAELDAAGRVVRLVEKPADPPSDLALVGVYLFDRTIHEAVASIAPSARGELEITDAIQWLIDHGHRVRTEVLEGWWIDTGKLTPLLEANRLLLEKLEARVDGDVDADSRLDGRVVVEAGARLVRSHVRGPAVIGEGTEIVDSFVGPFTAIGRRCRVERSEVEHSVLLDDSAVLDAGRIEDSLLGHHVRVTRSEQRPRATRLMVGDHSQVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB0</accession>
    <name>A0A7K0JPB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15750" checksum="199DB4E8F285E453" modified="2021-04-07" version="1">MRRSVAGGEIDDDPGRVDVEAVWRYLSEEAYWERWRDRGVVERQVRGAWRVVGAYDGATGRQVGFARAVSDGESFAYLADVWVAADWRGNGLGGAIVSVMIDEGPGARFRWVLHTRDARGLYVRYGFAAATERVLERPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI5</accession>
    <name>A0A7K0JPI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000073">
        <property type="protein sequence ID" value="MST31469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="17092" checksum="46BE607D9365614A" modified="2021-04-07" version="1">MSTSVVPPVITVAYVDAVFAKLDAVYGNALRSMAASRLVTQGAIGDVYAIFTQRLAPTAIQALGSLKASNFRNLRADPGDQHTHVDKLLFASNRCIFARVTVDYSGVDVHAPPPPFAQYEALTSREPINVREGDPTAWAIFYDNVLLKRQDVRDPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK3</accession>
    <name>A0A7K0JPK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_04065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000169">
        <property type="protein sequence ID" value="MST31902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="125"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="33958" checksum="CB8CBAF2A8E536AC" modified="2021-04-07" version="1">MTDLATRPAPAEALPATLEQLATQAFTFATASKSPATIRAYRSDWAHFTAWCDTHGLAALPAEPSTVALYLTDMAATAKVATLTRRLSAISQAHKTAGVDSPTSAQLVRTTMAGIRRTLGTAQVAKAPVLTADLRAITAGLDPARLIDVRDRAVLLIGFAGAFRRSELVALDVEDVVDGTDGLTVTICRSKTDQAGAGRKVGIPYGSHPDTCPVRAYRAWLAAAEITSGPIFRSVDRHGNVGTQRLTGEAVALVVKRHAGRLGLDVGAYAGHSLRAGLATAAAQAGASERAIMAQTGHKSLPMVRRYIRDGSLFRENAAAVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM9</accession>
    <name>A0A7K0JPM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2252 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="470" mass="51441" checksum="34FEBADA123B5820" modified="2021-04-07" version="1">MSAVLDHPTRRSPPRDRAEAGKAARERVPLEAHGEWAPPEGRADPVELLQTQAVSRVPELVPIRYGRMSASPFAFYRGAALVMANDLAGTPVSGFTVQVCGDAHASNFGIFGTPERGLLFDVNDFDETLPGPWEWDVKRLAASLAIAGREVHFDRQARESIVAACARSYRTAMKDFAAMHNLDVWYARLDTTVIQRWRSQLGPKQVKKAAKVAAKARAKDSARGLSKLTTEEGGELRFLSQPPLLVPLTELLPARQRSEVTSFVQLLLDQYAQTLRPELRDLLAGFRVVDMARKVVGVGSVGTRAWVILLLGRDGRDPLILQAKEAQASVLEAFVGASRFDNHGERVVVGQRSMQAASDIFLGWVRAKGIDDLERDFYVRQLWDWKGSVELDSGVPSGLSVYGELCGWTLARAHARTGDPIAISAYLGSADAFDRAVARFAETYADLNESDHRRLAAAVQSGDVVAEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN4</accession>
    <name>A0A7K0JPN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000088">
        <property type="protein sequence ID" value="MST31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="33335" checksum="0CC3B8A69138E5CE" modified="2021-04-07" version="1">MSRSYELKPARRASGRSDRWLPCVAVNSTPAVSVVIPLYNAAATIGAQLDALAAQTATGFEVVVADNGSADRGAEIARQHPIGAVVVDAGGVRGPSHARNVGSAMGGGDVLLYCDADDIVDRRWVEKLAAGLADSDLAGGSLELRRLNPSNGAWGVVDVNPMTRKPMPWFPSGNFGIRHAVLDDLGGWDESLLAAEEADLCWRAQLAGKSLRFEPAAVVHYRLSPSALVHVRKQYHYGRSVAVAQACRPELPLPTGGAPWRAAFGALRHPPQLRRSDAVCWAASTAFAVGRAGAASRAQRTRQQAVSAPIVGAGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT4</accession>
    <name>A0A7K0JPT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="365"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="457" mass="48513" checksum="C7EA2C26F9744A86" modified="2021-04-07" version="1">MYEIIAIDTPSLGDRSYLVHDGSTAIVIDPQRDIDRVLDLAEERGVHVAHVFETHIHNDYVSGGLALSGVTGAAYYVNGDDPVSFDREPVSDGDLIEVAPSLRVRVIATPGHTFTHLSYALEAGEEVVAVFTGGSLLFGSTGRPDLLGPDSTGVLARHQHASAHRLASDLPATAGVFPTHGFGSFCSASQSEGTESTIGAEKSANPALLMSEDEFVETLLAGLDAWPAYYAHMGSANASGPEAPDLSPPVLADAAELRRRIEAGEWVVDLRHRTAFASGHVAGSLNFGLDGSFATYLGWMIPWGTPVTLLGRTIEEVAEAQRELVRIGIDRPVAAATGDPGDWAGSEELHTYPQATFADLAGAAARAGVVVADVRRRLEWEEEHLAGAVHLPLHDLVARVAELPEGEVWVHCRSGYRASLAASVLARAGRRVVLVDDELPNADAAGLEVVRDVRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ32</accession>
    <name>A0A7K0JQ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000114">
        <property type="protein sequence ID" value="MST31679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="126" mass="14776" checksum="5D91BCC29066272A" modified="2021-04-07" version="1">MRDPRPGLPWSRRRVHRRDAYAAWMASAGWQTRRRQWLDTWTATHAKEPTCAACGGPWTLRHGDLHHRSYDRLGHETDTDLIPLDRACHTRLHQILDSTPQWRRVGRPQATDAIIARLRQANQEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ62</accession>
    <name>A0A7K0JQ62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000211">
        <property type="protein sequence ID" value="MST32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10575" checksum="4BCD0E11971013CD" modified="2021-04-07" version="1">MSAATREALTERIGGFARQTAFSAHSAAFPDDTPRLAEVAKRRVSGTDHPAAAEPGLVDEVAAEIERRRPDWAGTALDDTVDDDLAYGELLAASVGRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ74</accession>
    <name>A0A7K0JQ74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000213">
        <property type="protein sequence ID" value="MST32105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="2">
        <location>
            <begin position="45"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="628" mass="68010" checksum="812190C8E7A403A8" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ87</accession>
    <name>A0A7K0JQ87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000217">
        <property type="protein sequence ID" value="MST32118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8486" checksum="CF13B3107D643789" modified="2021-04-07" version="1">MEASTDGRAAAPAAERAGGPPVVPIGERLALSVEEAGALLGISRDLAYDLVARGELPSVRLGRRVVVPRKALEDALGRLADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE6</accession>
    <name>A0A7K0JQE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000222">
        <property type="protein sequence ID" value="MST32143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="18726" checksum="B5708B82A6F6E93D" modified="2021-04-07" version="1" fragment="single">MSRRAVPAHRATTAHLQALYPLVAGRGLGAHGVYLGRDLHGGPFCFDPWELYARGALTNPNLVVAGQIGRGKSTFVKTFVWRQLVFGRRAWIVDPKGEYRRLAAAAGVTPLRLGPGSPLRLNPLGVADPAARADPRVQVELVASVAGAGLGRPLGPAERTALDLAVRAAAEASREPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF3</accession>
    <name>A0A7K0JQF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000139">
        <property type="protein sequence ID" value="MST31799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="27174" checksum="F6B73FAD452F9E1D" modified="2021-04-07" version="1">MALEVRGLSKRYDDLLAVADVDLTVAPGELVAVIGPSGCGKSTLFDVVAGLADPDAGEVRFDGVAALDRLGASAYMPQRDALLPWRRVVDNVGLPLELQGCRRADARARARPLLERFGLGDFARSWPWQLSGGMRHRVAFLRTLVAGPGLVLLDEPFGDLDGITRSDLQEWLGDLLVEFGPTVLLVTHDIAEAVFLADRVVVLTPRPARVAAEVAVDLPRPRHAELREAPQVVALERRVREALRASAWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ2</accession>
    <name>A0A7K0JQJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_03740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000153">
        <property type="protein sequence ID" value="MST31839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="8">
        <location>
            <begin position="574"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="718" mass="73826" checksum="B5CD7AF7B4A45E47" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK9</accession>
    <name>A0A7K0JQK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000246">
        <property type="protein sequence ID" value="MST32211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="16358" checksum="4E26E3643E14EB19" modified="2021-04-07" version="1">MTHVQQAPGTQQPPTGRRPPPGGASANPGWAWFAAVMIGVGGFFNLIDGLVGITNARYYTNIARTYNVDLVVTNTIRTWGWVALAFGIVMLATAVGVTASLLWARVLGVTVVGLNMIFQLAFLPAYPFWGLVILTLDVVVIYALVVQVRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR0</accession>
    <name>A0A7K0JQR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="18513" checksum="E66D14EEC6DBDA7D" modified="2021-04-07" version="1">MGADAGVVRAAEPADAAGIGLVHVRSWQAAYAGHFPQEFLDALDPAARAEGWRRILGAAQRARQADLVAEVDGRVGGFVSVGPSRDSDASGAAEVYAIYLLAELWGSGLGRRLMDAALGTLAGLGFDAATLWVLEGNQRGRRFYKKGGWSIDGATKVDDSPGFPIAEVRYRRSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT4</accession>
    <name>A0A7K0JQT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE-type integrase/transposase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="144"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="355" mass="40098" checksum="7B4D158F7C64DECF" modified="2021-04-07" version="1">MGLSGPLPARAPAEVKELVLKHVDEAVAAGFSQAWVCSLWGVSDDRVHRWRQRLRTTGTLIDQAPGGHPTHGLLAWEIEAVLELAERWGEVDRSHRKLAHRGSYTDTVWVSPSTVRRVLAAHGLVLPDPGPREPVGRRPWPDWLVWAPNRIWGWDVTHFTRARRCAFAIIDLVSRKWIDTLCSLEETSTQVKVIFERALLAEGLVELITPERLELPADDPARPILLAVSDNGPQMTSDATKTFMAAMAVAQHHGRPHTPTDQAWIETLFGHIKGEWPHLERIDDPALLEHELARVRQEYNTVRLHAGIGYVTPDDEHDGRGDAIREARRQGLERARQQRLAYHRRNTTTTGEPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX1</accession>
    <name>A0A7K0JQX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4157 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="193"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="889" mass="95496" checksum="DC50D6B783095CA8" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ4</accession>
    <name>A0A7K0JQZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="424" mass="44819" checksum="8C848765423F7040" modified="2021-04-07" version="1">MIDHRPALVARCRSATDVATALGAARRGGLPVAVRGGGHSGPGFGTIDGGVVLDLSPMGSVEVDAAGRTARVQGGATLEALDAATGRHGLATPAGVVSSTGIGGLTLGGGHGYLSRRHGLTVDNLLEAEVVLADGTVVTASEDRHPDLFWALRGGGGNFGVVTSFTFRLHPVGAVVCGPTAWPASATADVLRWYRDFLPAQGDDLYGFFATMTVPPAPQFPEAFHLHKACAVVWCYLGDPDDAADVLAPVRALQPAFDGIGQVPYPALQSAFDAVYPAGLQWYWRGDFFRSISDEAIAAHARFAQELPTMQSGMHLYPVDGAVQRVGPGETAWAHRDVTFSEVIIGVDPDPGNAAAIKRWAVDYWEATHPYSAGAAYANFMMDDEGQERVRATYGSNYDRLTEVKAAYDPSNVFRSNLNIRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ5</accession>
    <name>A0A7K0JQZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000198">
        <property type="protein sequence ID" value="MST32024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029761525" evidence="2">
        <location>
            <begin position="30"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="29731" checksum="4AB29DD38D65EC93" modified="2021-04-07" version="1">MIATRRRAGVTVAAATVLAVLGAVLIVGGAGSHRDGAATTTRRATPPAASHARPAAAKTAGGGRPAGGFRPVPPLLAPVPDTPIETATDRQLAAGLAASGTIQTAQATPIPPPGYVGGWRPLPVGGTPDGWARAYLTRLLDIDFASQTRAGLGRWVVAQTAPELLPGVPASVQDKISYLSIFDTTALGGSSGPVPDAASWRNLARHDVTWRVGDLLTQPDPAWERLIAAGWQPPDARFAVEDLSGTLTVTAAHQPARLRHFSVAVYVGSAHWHPGYGTVLVSSWKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR31</accession>
    <name>A0A7K0JR31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="39705" checksum="52B4CAE701C1AA6F" modified="2021-04-07" version="1">MVEVSGSVAPGLEGVRRQFEANFAERGEVGASVCALVDGDVVVDLWGGLSDPGSRQPWRRDTLVDFYSAGKPLVACTLLRLVDAGLVRLDTPIASLWPAFAAGGKAGATVRHALSHQAGVPAIGPELTDDDLWSWDAMVDALAATPAWFAPGSRVVYHTNTYGHLIGEIARRLTGELPGTLLARIARAVGADVHVGVEPPDLDRCATVVFEPRRLGTGAPAGRDHPEAAMVQRGYFNPPGYSSFGVVNTTRWRRAQIPSTNGHGSAAGLAAFYAALLQPGRVLGGALTAEATRTQAEGHCPVLGEWVAFGLGFVPTSPRRRFGPSPGAFGHFGTGGAVGFADPARRVAFGYVMNHVVPRWQSSRNRALIDALYDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR36</accession>
    <name>A0A7K0JR36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000287">
        <property type="protein sequence ID" value="MST32408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="175"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="30569" checksum="5912F4942AC1C21D" modified="2021-04-07" version="1">MSTEDLTPEQRKAHRRILLCFVLATFSGVSWIFWYTWNDSLAAEGTSLGMAFIFLATGLVLWSHHLMDDGPFEEDFPELRSPAKQEAEVVARLDRGQIGRRRLLIGSAGAVGASVAGGALVNLRSFGPDPRSIEGTGWSIGRRAVTVDGSPVVDRGLPVGSLITVMPEGFLNSPQAVAVIIHLPPGANRALPGRGTWAPDGGQYVCYSKVCTHAGCPVDLYDHAAMELQCPCHQSTFAATHGAIPVFGPAGRALPQLPIAIDANGQFYSTGPFSSPPGPAVWFHGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR70</accession>
    <name>A0A7K0JR70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000211">
        <property type="protein sequence ID" value="MST32094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="25644" checksum="8803229C3CD7345F" modified="2021-04-07" version="1">MDEARFPDFTPSGNAAVNPDLYDVENRAIDPDGVLLRAMQELAPWVGKTIVDLGCGTGHWLAMYTEEAAEVVGVEPDPALLEVAGQHATTARVVAGSAEHLPLPDRSVDVVHARFAYFFPPGCDAGLREVLRVLSPGGRLVVVDNDQRHGEFAELLASSPFAVPQGRAEVTDRWWAERGAQRREVMSAWSFATRADLENVLRMEFPAAVADPWLARHPDATGLSYGYVLFAIGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ4</accession>
    <name>A0A7K0JRJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">GHK86_07425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <position position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="63"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
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            <position position="168"/>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        </source>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MST32552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="29834" checksum="1C484703E6ED5FF3" modified="2021-04-07" version="1">MAAIGLLAHEERPQAVELEDRTARWLERLGHEARRLKVGDHPGPAASEALAGLDVVVSLGGDGTMLRTVRLAAPVGVPVLGVNLGHLGYLTALEPDKLEAGLERFLAGDYRVDSRMTLEVCRRRAGSSRVLERHLALNDAVLQRPADGHTIQVAVAVNGHGFVSFVADALIVATATGSTAYNLSARGPIVSPRARVQIITPVAPHSLFDRSLVLDADERITLALERCRAADLVIDGLSVAEIADGELIEVTAGKDVHLVTFEERVFADILMQKFALGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ9</accession>
    <name>A0A7K0JRQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="10183" checksum="E6116737838102AA" modified="2021-04-07" version="1">MRELYELIDLIRPAVQADGGDLVLKDVDADAGTVEVQLQGACSSCAISATTLQAGVQRILKERLPWVTEVSGGVDEEMDWETSAAMGRGGYTPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS5</accession>
    <name>A0A7K0JRS5_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_07740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000344">
        <property type="protein sequence ID" value="MST32613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="522" mass="53281" checksum="1A165F10C3BF960C" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSD2</accession>
    <name>A0A7K0JSD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_08980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000410">
        <property type="protein sequence ID" value="MST32851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="233" mass="24045" checksum="0FD2A581CAC24B49" modified="2021-04-07" version="1" fragment="single">MSGSPARSPRAAIEPRVSRARCWRRAIRRRERRPLTQDPPALVTSRASTATTRGVITGGPPGAARHLGAPPRSGQPAGARAPHGPPRPHRCVVQTSFPSPPPRHCRRQSYEPGGGSGRGPIGPSAGPGCPQPALPPSPSARRGLVATGTLPWVSTLVTATPLRAGGDARGPHGARRWLVLPVAYLVGSVPFANLAATRTRGVDLRTVGTGTVSGTGLFAVAGFRVLAVAGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG8</accession>
    <name>A0A7K0JSG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_09065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000415">
        <property type="protein sequence ID" value="MST32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="10">
        <location>
            <begin position="74"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="9">
        <location>
            <begin position="168"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="322" mass="33685" checksum="C5BFF65DA53D60C1" modified="2021-04-07" version="1">RGLAPGRRAGAARRLAGRRVVLRPPPRGPARPGVRQRRLGRRRPVGRPLASGPGGLRREDVVSSTVVLAVCSALFGLAIGSFLNVVVYRVPNGQSLSHPRSACPGCGNAIAAYDNIPLLSWVVLRGRCRHCHGSISARYPLVEAGTAALFVGVALRFGWSWTTAAVDVFVAGLFALACVDLERYLLPRRIVYTTAVLSGGLLVVASAATGRWSDLAVGAACGAVAFGLFWVLNRVNPRWLGYGDVRLAGVIGFVLGWLGVDYALVGFLVANFAGVAVAAALMATGRMGRSSKMPYGVFLAAGSVVTVLAGAPLTQLLAAHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ8</accession>
    <name>A0A7K0JSQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000445">
        <property type="protein sequence ID" value="MST32981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="350" mass="36307" checksum="465D2576448FB816" modified="2021-04-07" version="1">GTSSAGSSGGGSGSGTSAAASGSGSGSSASTAGAKKVPLVIYAAEGYDAAEGKAFQKATGIPTTVDDNSTGPLTVKIEAEGKNPHWDLFWVDGATVFAGLDQQHLLLKGWEPSAISNYNAVGKSLIPADKSYIPTGVTMAAALVYNTKLVKHPPTAWSQLTGPQWKGAVGMNDPAVSGPTYPYVAGIMQQLGGVSQGEAFFKKLKANGLHVYQTNTNTLQALETGTIKVATVQSSAGIGAALSNKELKVEYLKKETTLPSVLGISAYVSKQAQAEAKQFVQFVLSPAGQKVMQSGDPTGDSLFFPLINGEKPLPAVGTPLAQIPTQSLNPYVWGGRENQLNTWFTDNIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV9</accession>
    <name>A0A7K0JSV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000457">
        <property type="protein sequence ID" value="MST33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="569" mass="59483" checksum="0E745CACBD46C12A" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW4</accession>
    <name>A0A7K0JSW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_09835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000457">
        <property type="protein sequence ID" value="MST33017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="34263" checksum="2E3E31E4673C0193" modified="2021-04-07" version="1" fragment="single">MSDEYATSTVTSPSGRSSSSSSVSWAGPWPVETTARTGTCSPPSGPGEPSHYPLRRRRPVAHRPARDHRAGWETGRVPPPRGAAAPDDRRGLASEAGLTTAARRILGNGPRWRPPEVWERAGVPESLARRLWLAMGFPHLPDGEPLLTDHDLQALRRAGELLVQGALDADHLVHQARLMAQAVSTVATAHVESLLAPGGGDALLTGLTGDSTDPVALVSELLEYLYRRHLYAALERAVLTNRGDEALAATAVGFADLSDFSARSAAATEDELTVMIDAFVTAAADLVAAHGGRVVKLLGDAVLFTVGDARAAAEVALDLAADHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX0</accession>
    <name>A0A7K0JSX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Allantoicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000459">
        <property type="protein sequence ID" value="MST33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="12887" checksum="AFA99C0017FBA6FA" modified="2021-04-07" version="1">PLLPHQRLEPDTRHVFEVADGGPIEWVRLDAYPDGGLARVRLIGAVDAEARRLAGYRWFNALPDDQALACLGSAGLSETAAATVLDRRPLTGAYRWDRSVGPSPDEVSTLTRILEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT83</accession>
    <name>A0A7K0JT83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000501">
        <property type="protein sequence ID" value="MST33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="18118" checksum="29550A63F87496D0" modified="2021-04-07" version="1" fragment="single">MSKLAPGGGGRGAPRYHAAVSDWNLAEVWETVAEERPAAEALVWGPRRWTWAELDRRADGVAGALLAAGLGRQAKVAQYLLNGPEYLESLFGAAKAGMVPVNTNYRYAEDELAYLWDNADVEAVVFDVSFAERAAAVRPRVPAVRLWLAVGAGPVPPWAVAYEDAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG5</accession>
    <name>A0A7K0JTG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000399">
        <property type="protein sequence ID" value="MST32819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="24737" checksum="A3DDDAC2D06B39F3" modified="2021-04-07" version="1">RGAGGRPVRWRVLFRADGLHRLTDPDRDSLRALGLRTVIDLRTRDEVTERGRVPDHDGLDYHHLPMLDVLPPDDELPRWERFEHVAAEYRRMLAEGAPTVAQVLALLADGERYPAVYHCFAGKDRTGILTALVLELLGVADDDIVADYALSQVGMQRMLAQLRARYPERSAEIDASAAAIASADPATMATFLAAFRAEHGGADAFAAALGLPGIADRLRALLLEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS3</accession>
    <name>A0A7K0JTS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000436">
        <property type="protein sequence ID" value="MST32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="1">
        <location>
            <begin position="34"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14676" checksum="8701A14F85B5866F" modified="2021-04-07" version="1" fragment="single">MSDPYAITLPLAGSRANHTGTWRVERPEYVTRVPPCARACPAGEEPRDWLHPAEEGDYERAWRRLVEANPFPAVMGRVCYRPCETACNRGQLDEAVGINAVERFLGDEALRHGWRLPGPGAPTGRRVLVVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT8</accession>
    <name>A0A7K0JTT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000572">
        <property type="protein sequence ID" value="MST33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="17535" checksum="48DAE353895CD8DA" modified="2021-04-07" version="1">MQEQVTERMVIRGSLDHCFAVLIDFELYPEWAADIKAVAVEERDAEGRPVRVTFRAAAFGRSTSYTLLYDYAEAPGRLSWIQVAGDLTRRLDGAYVLEPAGDDATEIRYDLVVELKVPLPGFVKRRAEGRIMGTALRELRARVEHEEEPLREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTX1</accession>
    <name>A0A7K0JTX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000579">
        <property type="protein sequence ID" value="MST33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="24922" checksum="EA6739F3C413F816" modified="2021-04-07" version="1">TVGRVGDRAVAFLPRHGTAHEWPPHRVNYRANLWALRELGVRRVIGPCAVGSLHPDLHPGELVVLDQLVDRTSGRADTYLDGPVAGHVSFADPYCPELGAVLASAGEAVGARIRRGGTVVVIQGPRFSTRAESRWFRSQGWDVVNMTQYPEAYLARELGLCYAGLALVTDYDTGVEGDDSVEAVTFEAVMEVLAANVAVTRRLLDVAVPAIPGAATCACRQLGWSGLTRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU26</accession>
    <name>A0A7K0JU26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000596">
        <property type="protein sequence ID" value="MST33441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="27843" checksum="DD3612570B4A9122" modified="2021-04-07" version="1" fragment="single">MTGGLLFAAAFLACAVEAVEATTVVLAVGVTRSWRSSWRGVLAGVVVLAVIVAALGPAISQIPLGPLRLVVGGLLLVFGLGWLRKAILRASGHKSLHDEASLYEKHLAEAREAGASSRRRGVMGPDAYAFTLSFKAVVLEGLEVAFIVVTFGANAKQVPLAALAAVAAIAAVVALAIAVRAPLARVPENTIKFAVGVLLSSFGTFWGAEGAGAHWPANDGSLLWLIPVMMNAGIIPPVDGYLAGLGDLLRAHGALLTFDEVKTGLTVGPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU28</accession>
    <name>A0A7K0JU28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000599">
        <property type="protein sequence ID" value="MST33447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="8941" checksum="24E9024EA2A056C9" modified="2021-04-07" version="1">MRTTVRLDDELYRQAKVRAARSGRTVASVIEDALRVGLQVAARAAGPSPRLPTFGARGPLPGVDLTSNAAVLAAMDDDAPVDAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU54</accession>
    <name>A0A7K0JU54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000607">
        <property type="protein sequence ID" value="MST33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="25180" checksum="60FDAD4A796702F3" modified="2021-04-07" version="1">MTIADQPADAAPRAGTRPAIDRTSATDAAAREIRALILTGELPAGSLIHQGELADQLGLSRTPLREALQRLQAEGLIRIDNHRGAVVARPTRDDVNQIYEVQMMLEAAAARRAAAVRTPEDLAGVRAVLERHQESPGGISWMESNIAFHTAIYGIARRPLLMEMIGMLRNRAALYVNFLARSPEGRARADREHWEMYEALAAGEGDRLADLVLEHLQGTLDWLQDVIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA9</accession>
    <name>A0A7K0JUA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-sensing transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_12480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000630">
        <property type="protein sequence ID" value="MST33532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="8919" checksum="C64D04AFEE5808FA" modified="2021-04-07" version="1">MRRIEGQARGIEKMITDERYCIDILTQIAAVTTALETVAGKILDDHVNHCVAGALASGDEAVAAEKSRELLEAVHRFIRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB4</accession>
    <name>A0A7K0JUB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000633">
        <property type="protein sequence ID" value="MST33537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="530" mass="58083" checksum="47FD0792484DC551" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG6</accession>
    <name>A0A7K0JUG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000524">
        <property type="protein sequence ID" value="MST33214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="35770" checksum="40CFF6CE3EC47CA1" modified="2021-04-07" version="1">MPLTDLSLAECLAYRPVVPEPPDLDAFWAATLEEGDAGGDPVGRFEPVRTGLALVDTFDVGFAGFGGEEVRGWLHLPAGTSAPLPCVVQFQGYGEGRGLAWQQQFWAVAGYAHFVMDTRGQGWGSLPGATPDGAARAAGEPSPITWGLRSPHDYYYRRVFVDAVRACGVLGGHPMVDADAVVVTGASQGGGIALAAAALVPGLLGAMVDVPFLADVRRAVDVCGVPPYADLATVLQHRPWMAEAALQTLSYFDVAALASRAAAPALFSIAMMDPVCPPSTCFAAYHRYGGPKQLRVYEFADHAGGEATHLGEQAGWLASLLASRSSGSSGKDDLQAGRGGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH4</accession>
    <name>A0A7K0JUH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000658">
        <property type="protein sequence ID" value="MST33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="913"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112217" checksum="F7833F51BFFAEF90" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ2</accession>
    <name>A0A7K0JUJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CocE/NonD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="20048" checksum="38C38F2895E7FAD0" modified="2021-04-07" version="1">MTPSATPGVGGASLNPANAGRRNQRRREERADVRTWTSDPMPAGLVLAGPVAAEIWLRSSNWHTDLFARLCTVSPSGRSRNLSDGILRLEPGEEGRVITLGTAADGEVTGADDGVVRVRIRMWPIGIEVRAGHRLRLQVSGGAHPLVARNLGGGERLGSATRMVPADHDVFQDPEHPSALLLPHALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK1</accession>
    <name>A0A7K0JUK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000511">
        <property type="protein sequence ID" value="MST33189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="23692" checksum="1741851B897CD2C5" modified="2021-04-07" version="1">MKAVIVGAGNVGVFLASDLRAAGHDVTVLEEDPDLVTELATSHPEVHWVAGDGCEYTTLDRIGLAEADVVVAATGDDEDNLVVSLLAKQEFAVPRVVGRVNHPKNEWMFNQTWGVDVAVSTPHLLSAVVEEAVSVGSLVRLLRLDASGVRLVEVTLSGGSPACGVALAALGMPRDATVVAVVRRGGVVVPRGDTRLDAGDEILVLVSPEAEDEVRRLLTGPVGVPGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL7</accession>
    <name>A0A7K0JUL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000664">
        <property type="protein sequence ID" value="MST33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="14309" checksum="424CE3A082CA29BF" modified="2021-04-07" version="1" fragment="single">MDPYAEQLVDAAEAALPAWVVRCVTERITAWSGAAAPEVLARAEEAGRQACHEVGGALRTLLAADIDEQRATPLSLLREAVRFPTAVLEEAGVPPVERDDFAERAFPGDPYDLSPASFADVDPALAGPGLAWGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR2</accession>
    <name>A0A7K0JUR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000693">
        <property type="protein sequence ID" value="MST33696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="17962" checksum="95B090C2C8461168" modified="2021-04-07" version="1" fragment="single">MTTDRMLARQAARERARRRRLRRRRRTFTVATLLLVVIVVLVARSLGSSSTPSKQPASDPASAAGSSAASNAASAPKGPAPIPSIEAGVESWALPSVISRSSVVAQGSNLLVAGGLTPAGTSTPTVQSIDPATGSVTTAGSLADGTHDAAAATIGGQLWVFGGGNPNTFATIQRFASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR3</accession>
    <name>A0A7K0JUR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000693">
        <property type="protein sequence ID" value="MST33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAGPA" evidence="1">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="27368" checksum="CCB8A4461CFD29CE" modified="2021-04-07" version="1">MPRTTTTTLPVPQPGWTPVTETSKAILTDTRTVHLPDGAAVTLVRFHAGTYRLDFHLGSSDPPGASTAATALDGDAVSVAERPRLIAAFNGGFKTDTGSGGVEADGHVFVPLVTGDASLVVDANGAARVGVWGQGLPAPGEHVVSVRQNLTPLISNGVLSPQIGNVAAWGAELYGVTNTARSAIGTDPSGNLVYAASMGALPVDLATALSDAGVTNAMELDINPYWIQGDVAAHPGGPLQAAIPGQQRPADTYLAGWTRDFFAVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV3</accession>
    <name>A0A7K0JUV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000703">
        <property type="protein sequence ID" value="MST33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="387" mass="42803" checksum="9C46A2DD87DDD85E" modified="2021-04-07" version="1">AALAAGGALSACAAAEASVTVPLARQDNPVRWPVYKDNPAIASGLEPEKGATLQIYNWVAYINSATIKNFCKKYNCHAQVTTFNTMDEAIAKLQSGQLNFDVFIPTPDVLGPLILGKLLQPLNHSYIPNRHQTWPDYASPFYDVGARYTMPYTVYTTGIGYRKDLVDQDPYRMANPWEMLWNPKYYGRTGILDDYREGLALGMLKVGIHDVNSTSVAAIAESRRQLELCEKLTAAIIDNNDFTDVPTGQTAVHHAWSGDMASSWYYLPKGVKPDVLGYWYPPEGNGPVANDTMAVLRSSRSPVLAHLFINYFLDLHNALDNASYTGYQQPIEGVTPESMVKAGIIPPSLLSTTVPRSYFRKGLFELELPAKTDQEYQVAWTTFGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV74</accession>
    <name>A0A7K0JV74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system death-on-curing family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000728">
        <property type="protein sequence ID" value="MST33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9656" checksum="EFCCC8B287073A45" modified="2021-04-07" version="1" fragment="single">RYLALDDYLAIAVEVTGQRVATIVGAADHALADSALHAPMAGFSGRDLYPDFVDKAAVLIVRLAKNHPLPDGNKRAAWASLRVFVALNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV76</accession>
    <name>A0A7K0JV76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000742">
        <property type="protein sequence ID" value="MST33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="17422" checksum="66A203F4E72C8352" modified="2021-04-07" version="1">MAKTISPSPEPSGSPPGNNVRDRKHKWIQAPDGSWVLEPKRHHVFRWIVGTAAALLALIVVFVGVVINGAVDQLNVEQQAHAITPTQYTAVKLGVTQQQLESQLGKQPENAQEFVSKGILNQGQLNSSCVYYNESGKTFGHVYQFCFTNDQLETKSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA9</accession>
    <name>A0A7K0JVA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000614">
        <property type="protein sequence ID" value="MST33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="270" mass="28411" checksum="3F01FE9B874852E2" modified="2021-04-07" version="1">MWPARGRASDTGPVDPRPLALVTGVSRGPGIAAAVARRLAADGWDLALSGWRPYDAGMAWGRHDDELDELLLGLTGSGVRTRYFDADFADLDAPAGLYDAVVEEFGRSPLALAVVHTHDTGGGLLEMSGADFDHHMAVNARATLLLAAEHARRFAGPAGRGRIVTFVSGLPLRGSVAYAASKGAVHWMTVSIAAELADRGITANAVNPGPTDTGWMSPPVRQRIRGESPLGRIGRPEDAAELVAWLCSEAGGWMTGQVLTSDGGWSTIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC9</accession>
    <name>A0A7K0JVC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ORF">GHK86_12105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000603">
        <property type="protein sequence ID" value="MST33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="53"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="30155" checksum="8FF14890910C081E" modified="2021-04-07" version="1">MPRAIWSGSVSFGLVNVPVKLVTATSSKDVRFHQLHAPDHARIQQKRVCSADGEEVEYAEIVKGYDLGGGRYVVVEPEELASLDPEGTRSIDIEEFVDLADIDPLYFEHSYYLVPDERAAKPYALLVEAMQRTGKVALGRFVLRTKQYWATLRARDGVLVLATMLYADEIVAIEDLGVATTEQTAPSERELAMATQLVESLATEFDPTRYHDEYREKVLALVEAKAEGQVIAAPAEPAPAAPVVDLMAALEASLAAAKARGSGAGDGEAPKGRRKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV4</accession>
    <name>A0A7K0JVV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000843">
        <property type="protein sequence ID" value="MST34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KdpD" evidence="4">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="173"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="34844" checksum="817C1640F78C226E" modified="2021-04-07" version="1">RRRVAYRGTEFEEMDLDAVLARHPEVAVVDELAHTNVPGAGRHPKRWEDVIELLGAGIAVISTVNIQHLESVADAVERMTQVAVRERVPDWVVRRADQIELVDSSPEQLRRRMLHGNIYPPDKISQALTNFFRTENLTALRELALRFLADETEEELLAYLQRHAVTKLWETTERIMAAVTGAPGSDGVVRRAARIAGRVKAELDVVHVVPADAPADVDPPAIATLRQLSADLGAHWHELHADDPVRAILDLARAQQTTQIVLGSSRRSRLHELTKGSFLRRIVREASDADVDVHIIARRTPHELADPLSDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV5</accession>
    <name>A0A7K0JVV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000838">
        <property type="protein sequence ID" value="MST34073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="22454" checksum="87F2150D0174F0F4" modified="2021-04-07" version="1">IFAWWAERITGGGADAHERLTELAAAQPVGAHGLVALDWENGNRSVLVDHELSGVIVGLTLATRPEDVYRALIEATAFGTRTIVEAFESAGVTVRSFTAAGGLVKNRFLMQTYADVLRRPISLIGTEQGPALGAAIHAAVAAGAHPDVPTAAEAMGRRIERAFEPRPDAASAYDALYDEYRQLHDHFGRGDDVLHRLRRIRNATLGGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW39</accession>
    <name>A0A7K0JW39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000876">
        <property type="protein sequence ID" value="MST34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10146" checksum="C8C5B24C1F46034C" modified="2021-04-07" version="1">GPAGPASDGRGLGGPAAPGGPAPGGPALTERERDVVELLVDGLTNQQIAERLRISRRTVETHLQHIFDKCDARSRTGVVLYALRHALVRHPAAEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW89</accession>
    <name>A0A7K0JW89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000738">
        <property type="protein sequence ID" value="MST33824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="441"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="573" mass="60933" checksum="A46BF495AC944EE0" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC8</accession>
    <name>A0A7K0JWC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000918">
        <property type="protein sequence ID" value="MST34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="6">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="294" mass="30880" checksum="BCD722F23C72E904" modified="2021-04-07" version="1" fragment="single">MTTPHPPPAARPEEAPGPAPPPDAHHALAAHEVVLLLGTDVAAGLTSHEVQQRRRRFGANELREVDAGGPLRRLLGQVDHPLVIVLLVSAVVALLLGETVDAAVIFGVVVANTVIGFVQESRAEAALDALRALVRTAAQVRRDGRRQSIASVEVVPGDVAIVEAGDKVPADLRLVESVELRVDESALTGESLPVAKDEVALAVDTPVADRRNMVYSGTLVTHGAGTGVVVATGEETELGEIHRLVSSAEELETPLTRKLDRFSRLLTVVIVGLAALTFLVGVARGERVAGMFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI6</accession>
    <name>A0A7K0JWI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000773">
        <property type="protein sequence ID" value="MST33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="200"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="26476" checksum="61460AE8F5325B4A" modified="2021-04-07" version="1" fragment="single">MAPDEGDFFDRTRWGWHALFAAVAALAASFLAVDGAAAWVPLLAALVAAYVAAFVWPGGGCWAAGRLPEPWDAALRLAYLAVAYSVVGILAWVDPNALVLLFILFPQTFLTLDLRWAVVATFVLTAIYTLVLLARAHWSAQALRLEGVGGVVTAVFAIAVGAFITGLVHQGEQRRRLIAELTATQSERDEAKRAADVAAERERLAREIHDTLAQDFTSVVMLAQAARAALAGGDPDAADRRLGQIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL7</accession>
    <name>A0A7K0JWL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_14575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000780">
        <property type="protein sequence ID" value="MST33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="11210" checksum="3AD354AA88F86D5F" modified="2021-04-07" version="1">MNAPGAGGNVFPVVLGWLLAASIPLVVAQAVVTLWALVAVLLNNDRYGNGNQLVWVVVVLLTGVVGALLYVLIGRQPWEVVSEAVPGRRQRLAAIRDPWGAPGDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT5</accession>
    <name>A0A7K0JWT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SidA/IucD/PvdA family monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000989">
        <property type="protein sequence ID" value="MST34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="408" mass="44090" checksum="A53113C0DA448B9A" modified="2021-04-07" version="1">MQDMSDVAIVGAGPYGLSLTAHLRAAGLDVRCFGRPLHLWRTMMPAGMILKSNGFASNLSSPDGAHTLQAFCAETGRPYAHYGLPVHLDTFVAYGTWFQEALVPDVEPVLAQRVTDDAGGFRLELDNGEEVAARRVVVAVGVEHFPVVPPELRRLPADRWSHSSAHDDLSGFAGRRVAVIGGGQSGLESAALLHEHGAEVDLVVRESRLAWNTAPLVPDRATFARLREPESGLGSGWSTWFYSRHPELFRRLPERTRVYRSRTALGPAGAWWLGDRVHGRFPIHLGYRIASVSDGVDGVALRLEGPRGPVSLAVDHCIAATGYRPDLERLGFLDESLRRRLRTVAGAPAVDAGYESSVPGLSFIGPAVAATFGPVMRFVYGSDHAARTVAGRLTETATDRPRTLALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW4</accession>
    <name>A0A7K0JWW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">GHK86_15160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="WJHE01000829">
        <property type="protein sequence ID" value="MST34054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="291" mass="31366" checksum="24927156CCEFA773" modified="2021-04-07" version="1">MLRLVLPKGSLERATLELFEAADLTVARSSSVDYRASVSDPRVAEVLILRPQEIPEYVAEGLFDLGITGRDWIEETASEVVTIGELRYSKASDQPIRVVLAVADDSPVRSVADLPAGVRVSTEYPRLTARFLEAHGVRADVRLSHGATEAKIPEIADAVVEITETGRALRAAGLRIVATVLSSSTELIANPRAYEDDAKRHAMGQLYTLLQGALVARQRVLVKLNVPAPDLDRIIGVLPSMKAPTVSQLFGGEAFAVEAVVPKREINTLIPALKDLGASDIIELPIAKIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX00</accession>
    <name>A0A7K0JX00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000986">
        <property type="protein sequence ID" value="MST34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6913" checksum="7ED931BA535CBB6F" modified="2021-04-07" version="1">MRVRIDQERCQGHGRCYALAPEVFAADDDGFAEVVTDPVPPGLEERTRLAARNCPEEAVVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX52</accession>
    <name>A0A7K0JX52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000865">
        <property type="protein sequence ID" value="MST34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="26395" checksum="E7097F8F1276CDE2" modified="2021-04-07" version="1">MGYWVARCLFTPVLLVFYRVRPSGRANLPRRGPVILASNHQSFMDSMFIPLCVARRVTFLAKAEYFDNPRTAWFFRAMGQIPIRRDGGSQSAAGALAAAREVLDAGGILAIYPEGTRSPDGRLYRGHTGVARIAVTCGVPVVPVACAGTAAVQPIGARRPRLWKRVVVRFGPPLRFDDPPESADDLAVLRRVTERIMDAIAALSGQERVDAYARRRREGDHWVADLPASPPPAGAGGELPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX77</accession>
    <name>A0A7K0JX77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol mannoside acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_17710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001067">
        <property type="protein sequence ID" value="MST34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="27601" checksum="2D41D0930CC60AF1" modified="2021-04-07" version="1">AALAARRAALAAHLRRICGPGATGAQLDALVGDALASYGRYWAESLRLPHLSREVVLADFAVDGIEHIDAALAAGRGAVLALPHLGGWDWGGSYLATAGYPTSVVMEMLRPPEVFSWFADLRRRLGLEVIAVGPDAARDSVAALAANRLLCLVADRVVPGVTGVPVDFFGARALLPPGPVALALRTGAPLIPLAVYFRPGTPGHRAVVHPPMRLERAGAFRQDVAAGTQALARELEGLIRAAPTQWHVLQPIWDDDAPPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD2</accession>
    <name>A0A7K0JXD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_15930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000895">
        <property type="protein sequence ID" value="MST34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="323"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="41320" checksum="5401455A1A410402" modified="2021-04-07" version="1">MITLDDIEDARRRVAPVLVPTPVRHSPALSRLAGRPVLLKPEYLQRTGSFKIRGAYNRISRLPEGMPVVAASAGNHAQGVALAAALTGRRSTIFMPAGASLPKVEATAAYGAEVRLEGQVVDDCIALARRHAEVHGGVYVPPFDDADVIAGQGTVGLELAEEAPDAELVVVPTGGGGLLAGVATAVQHTRPGVRVVGVEASGAPTVATALAAGHPVPLEELRTMADGIAVRSTSTLILELVRAHVAALVTVEEVELSRAMLVLVERAKAVVEPAGAAGMAAVLAGRLPGDGPVVVLLSGGNVDPLLLTRIIEHGLAAAGRYLSLRVVMRDRPGALAALTAELAALGLNVLSVEHHRWGRTLAPDQVEVLVTVETRNEAQHKEVVEALAGRGFVVETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD5</accession>
    <name>A0A7K0JXD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001098">
        <property type="protein sequence ID" value="MST34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="15588" checksum="5A6B022156EF1C0E" modified="2021-04-07" version="1" fragment="single">MRATRSRSWLVDQLPVGMLDDRFFHDFVRLFQAGADTILEQVDNIDNIVDLTVAPIEMLRWLAGWTGMTALELAPPSALSEEEHRRALRAWGASLGRRSTPLGLASFLEAVTGGPVDVEDPGGILVAEGVRTTADPALPGRGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ5</accession>
    <name>A0A7K0JXJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000915">
        <property type="protein sequence ID" value="MST34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14495" checksum="15C3543B662CC6EC" modified="2021-04-07" version="1" fragment="single">DGWLALHGRFGRLPLADVLAPARSYALDGFPASPGLVAAFPRVAELPEAEDYRAAGGLSPGALVRRPGVGRALDAIATGDRAAFYRGEFGDGFLAVTAGEHTAADLDRVQADWVDPVAADAWGHRIWTAPPNSQGYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK5</accession>
    <name>A0A7K0JXK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000917">
        <property type="protein sequence ID" value="MST34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="28141" checksum="9B822E48BAA44720" modified="2021-04-07" version="1" fragment="single">MAPTVCMVTLTWVPELVWVPAYETVGGDVRRKPNDQPAISATAPANSTPSTLARAQTGQSFLVGKSDKCPPFGVSRHVRTIDPGSERFGRLPVALANGSGSYVATGMAVKHRHRGTRPAQVGTLLAGLALAAGACGSSSTSGPARSTSSPTTHVSSAPAGRAPTVLLERGTPVGTVLVDAAGHWLYLNHADTAGGVGSFTCSGSCLRSWHPLLLPPADLAPVVPRALAGEFAVVQRPGGGQQVAFSGAPLYRWVGAGKPVTTGGWAPAVVPATSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL8</accession>
    <name>A0A7K0JXL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GHK86_18445</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01001157">
        <property type="protein sequence ID" value="MST34696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="5"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MST34696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="16839" checksum="EFD111FFC16FFD51" modified="2021-04-07" version="1">MLVLGGTRSGKSTVAEGLVADLASQADGTVTYVATVSVIDEGIAQRIATHQARRPPTWNTVELASSSELPTVLTQLDGSVLLDSLGTWLASAPDLEVDGQALVHALEVRSGSTVLVSEEVGLAVHPPTALGRAFVDALGHLNQTVAAIAERVLLVVAGRTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM5</accession>
    <name>A0A7K0JXM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001121">
        <property type="protein sequence ID" value="MST34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="270" mass="29014" checksum="CCD1832A87D77C40" modified="2021-04-07" version="1">MTTADPTSVDTAGRTARTPQTALLETRDVVVTYGGVRAVDGMSLRVRAGEAVGLIGPNGAGKSSFLATLGGQQRVSSGHIALDGEDVTGLPAHRRARLGIVRTFQMTSEFGGMTTFENLLTAGVGVEGASLANVVLHRRRQREIEQSARARVWEVLERFEATHIADLYGRELSGGQRRLVEIMRCLMRSPKVLLLDEPMVGVAPHLVQRLVGDLKSLRDEGIALVIVEHALEVVQELCDHVNVMGLGKLIAAGTYDEVVRDAAVQAAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ7</accession>
    <name>A0A7K0JXQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001183">
        <property type="protein sequence ID" value="MST34736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8882" checksum="79ACDE92DFFEE76B" modified="2021-04-07" version="1" fragment="single">LLNVDLQGACQVVVDIHSRFLSIAAHAHADALAVEVRHGGVDVLADPGTYCYHGEPAWRAYFRSTLAHNTLELGGTDQATSGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS5</accession>
    <name>A0A7K0JXS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1707 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001199">
        <property type="protein sequence ID" value="MST34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17538" checksum="F3429BC3FE29082B" modified="2021-04-07" version="1">MTFPPDPPPSWGSPPPWWAPRTGGQPRVHPQAMRVSNAERAEVTDALCKHFADGRLDEGEFNDRAARTAAAKTRADLAPILADLPPLDHPHHPEVPAVPRRHNPLLWAVVLVLCAPFLLGGAVALSAGVFGMAHAAAHAVFPLFVLAVVILLLSRRRGRHPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU5</accession>
    <name>A0A7K0JXU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001206">
        <property type="protein sequence ID" value="MST34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="9239" checksum="FD3C795923AEE054" modified="2021-04-07" version="1">MGIRPDCRHYLARTSACGEVSERCRLGAAEELPFACPEHCLFYEQRASMGAGWAQAPATPMSNTADGLANLPPPRRRRGKGKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY06</accession>
    <name>A0A7K0JY06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001251">
        <property type="protein sequence ID" value="MST34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="13177" checksum="E099B262F85A75D9" modified="2021-04-07" version="1">MARSEHSGAPAAPVAPAAVELPSDGQVRAAVTAFAMLAEPTRLRLLWLVSAEELDVSSLAARLATSVSIVSAHLAKLRLAGLVETRKDGRHVLYRARDTHVRRLIAEAMFHADHQITGAADHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY16</accession>
    <name>A0A7K0JY16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001256">
        <property type="protein sequence ID" value="MST34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="26773" checksum="7E3CC28FA7E9C072" modified="2021-04-07" version="1">LIRHNLAGDFRHLDLSRARVVLVEMADHLLPGFSPKSQAAAAATLHRLGVDVRLSTSIATVEADGVTVTPRDGGSPERIEADTVVWTAGVRANPLGACLADDLTWGGRVPVEADLTLPGHPEVFVVGDMAAATDRHGQPLPQVAQVAIQGGRHAARCIARRLAGRPTRRFRYHDHGSMATIGRRSAVAELPGGLVVTGTAGWLAWLGVHLVFLVGFRKRALVLATWAWNYITWDRASRVIMETRDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD5</accession>
    <name>A0A7K0JYD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001280">
        <property type="protein sequence ID" value="MST34892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="5099" checksum="A8002D942704336B" modified="2021-04-07" version="1" fragment="single">MRTSSTGSCEAAELAADAVVVEVDRPGAAVAGGAVVEGVAVWSVVAGAVVGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG8</accession>
    <name>A0A7K0JYG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001079">
        <property type="protein sequence ID" value="MST34579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="19593" checksum="ACB4F63048CF5871" modified="2021-04-07" version="1">MSRPPGGRSAQTLSEGDRRAVAAWAADCAERVLPVFETEAPGDDRPRKLIARARAYARGELATAEGIRVRFTGGVSVGEVDAPAAAAAARAAGQAAAVCHMGAHALGAAAYAVKAVSLAHPDQPHAGGDEIHWQLEHMSPTVRAALRSLPPVGENTSGPLGPGLLSSGQLATTIRTLQADLATINLSEPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ2</accession>
    <name>A0A7K0JYJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_20160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001374">
        <property type="protein sequence ID" value="MST35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="26668" checksum="0D55BD0AF4DB42D4" modified="2021-04-07" version="1" fragment="single">MTTTRDWPDPDPGGAVTTTKRVLEIEHLRTEFHLRSATVGAVDDVSLTIDEGECVGLVGESGCGKSTTGLSVMRLLPRVGHITGGRVLLGGRDLVALSEAEMRRVRGNEVSMIFQDPMTSLNPTMTIGAQVAEPLLIHGTTSKKAAEARALEVLGLVGIPNPRERMDDYPHQLSGGLRQRVMIAVALSASPKLLIADEPTTALDVTIQAQILDLLDRLRAELSMAVLLITHDMGVIAGRTDRVMVMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ03</accession>
    <name>A0A7K0JZ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001439">
        <property type="protein sequence ID" value="MST35112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="20391" checksum="F4B3BA7D1D10EF1E" modified="2021-04-07" version="1" fragment="single">MPRPLTTSQRYMPGLDGIRAIAVLGVIGYHLGLAWIPGGLLGVGVFFTLSGYLITDLLLAAWERTGRLQLRTFWVHRARRLLPALFVLLPVVLVWVAVARPAMLGEVRGQALASALYVGNWWLIAQHVSYFARFGPPSPLGHLWSLAVEEQFYLIWPWLLAAGLAGVRSWRRRRPAPPPAVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ12</accession>
    <name>A0A7K0JZ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001515">
        <property type="protein sequence ID" value="MST35201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="33014" checksum="DB33F35A8D6C9148" modified="2021-04-07" version="1" fragment="single">MGVADRIIQHADRLTAAERRVAAIMADEPDTVAFGTVALIARKAATSGPTVVRFAVKLGYAGFVELQSDVQRELSLLLGPARERIRQQPPADLLARVAAVEEHNVRRTLSSVPAAQFDAVVARLADPARAVWVLPGDITEPVGCTLAQRLTQLRDGVTLVGGSQVVAARVLARLARGDTLVAIDIRRYESWLVELARWAVGAGAAVIAITDGPLSPLAGLAAETLTMSAEGVGPFDSMTAGIALANALVAGVAARVRTTATPRLDRIEAVWTATGALVSDPTGAVRQPPGPARRLGDGIDGRSRPTDGAGKAASARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ79</accession>
    <name>A0A7K0JZ79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001516">
        <property type="protein sequence ID" value="MST35203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="14359" checksum="A545A729AD832AC7" modified="2021-04-07" version="1">MAMLQQHPEVPDASRAVTLMTAILGGEHLRDGGDQSLFASAIKEAAQRTASSTLTYLVGAEWVAYVLGTLGLIGGAALCLITRLNADGLSVHPYVIPGLILIAASLFWGVLMITLVKALRLFGVWTLSALGGGRDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA7</accession>
    <name>A0A7K0JZA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001543">
        <property type="protein sequence ID" value="MST35238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="23428" checksum="0D989D92458435A7" modified="2021-04-07" version="1" fragment="single">MDANGLRRAFTQYFVDHGHTAVPSAGLIPLHPRAPLFTNAGMNQFIPYFLGEERPPYPRATSVQRCVRIRGKHDDIENVGRTTRHATFFEMLGNFSFGDYFKAEAIPFAWELLTERLGFDGDRLWVTVYTDDDEAADIWADQVGVPRDRIQRMGDDNFWEMGETGPCGPCSEIYFDRGPSWGAEGGPVAGGEERFCEIWNLVFMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMH2</accession>
    <name>A0A7K0JMH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterodisulfide reductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="212"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="396" mass="44841" checksum="18BC798DB6A91F3D" modified="2021-04-07" version="1">MSSPAVNVVLSKKRRFDREPDRRSEDFHGRLFELEEAGEWVVHRVPEDHVKVTTKYGNEKKIPRAHLWHHKSCGQCGHIPGYSTSIFWLMRKLGYDYEDPRDQTSCTAWNYYASATSNPAAQAAVALRNFAAAYEKGYYPLIHCGTSYGHYKEVRSELLRHGDLRSEVRRVLGKLGKPMVMPEEIVHYSEWIHALRGELAALQVRDFSGIAVTVHPACHYYKLVEGDAIFDSDVYGGQRTAVVTGIAEALGAEVRNYSTWFDCCGFGFRHILVQRDFTRSFATMRKIEVMKEEADPDVVLTHDTGCVTTLDKSQFAARAHGHNVGVPVMSEAQFAALALGAHPFKVCQLHWHSANYRPLLEKMGIDWRQAWSEFEAAVEKLDSGGQQYLTWADVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMJ5</accession>
    <name>A0A7K0JMJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="19604" checksum="B028BC6EEED58E53" modified="2021-04-07" version="1">MQARPGWEGRFYEDLVPGDLYRHPLGRTISEADNTWFTLLTLNTNEMHFNARYAERSEFGRILVVSTLTIALAVGQSVTDLTQHAFANLGLDEVRLTHPVFVGDTLWSESLVLERRESASRPHAGIVTVRTRSLNQDGDEVLSFKRTFYVYRRGAPQVEGTFPAAKHPISDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JML7</accession>
    <name>A0A7K0JML7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pup</name>
        <name evidence="7" type="ORF">GHK86_00475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000018">
        <property type="protein sequence ID" value="MST31206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="modified residue" description="Deamidated glutamine" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="65" mass="7465" checksum="B7E02DB9F923F2E8" modified="2021-04-07" version="1">MAEREQIKRQAPSRTEEETVEEVPATSRKGDELKAELDDLLDEIDEVLEENAEEFVRSYVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMR4</accession>
    <name>A0A7K0JMR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="131"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="511" mass="56618" checksum="47C592E8162AB2C3" modified="2021-04-07" version="1">MLQHWHAGRPKTVVAASLDVDVKTVRKYVAPAEAAGMAPGDRPPPGRAEWAALVTGWFPELVDAQARSKSFGEIDRFRSQIAEMLETNTVTTVWQRLRDESGLRASLTSFRRYVWREFPEKIDESKVTVLRPDVPAGEEVQIDYGFLGNWVDPATERVRRVWAFVMVMACSRFMFVRPVLRIDQTSWVAAHVAGFEFFGGVPRRLVTDNLKTGVIKPDLYDPKLNRAYAEMAEHYGVLIDPARAAKPKDKPRVERQMPYIRDSFWRGRAWVAETDMQTGAVAWCRDVAGGRTHRSLEGAAPARVFEAVELPALTPLPRGPFVLASWSQPKVGPDCHVKVGKALYSIPWRLIGFRVDARATERTVEFYLGAQLVKTHPRIERGRQTDWDDYPPEKVAFFMRTPMWCRKKAAELGPNVAAVVADLLAGGALHHLRAAQGVIGLAEKHGEGRLDQACARAVTVGDPSYRTVKGILAAGTESEPPAAVGAPAAPAHLHGPDGLFAHLDNEMEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN86</accession>
    <name>A0A7K0JN86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin-synthase adenylyltransferase MoeB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moeB</name>
        <name evidence="5" type="ORF">GHK86_01275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000046">
        <property type="protein sequence ID" value="MST31363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="392" mass="42111" checksum="5EE506A38C2F3AAC" modified="2021-04-07" version="1">MPSFRDLLKTTKDRIREVDTAGAEDLLAQPGTVVLDVREPDEYEQGALPGAVHIPRGHLESQVEGRIVDRDARILVYCAGGTRSAFAADTLGQLGYGDVVSMAGGFNKWKDEGRAWAAPASLSPEQRNRYQRHLLLPEVEVAGQQKLLDAKVLLIGAGGLGSPAALYLAAAGVGTLGIIDMDVVDASNLQRQILHNMDRVGERKVDSAKKTLTAMNPDVNVVTYDVRLGADNILDIFSGYDVVLDGTDNFPTRYLVNDASVKLDIPVVHGSIFRFEGQAAVYLPHQGPCYRCQVPEPPPAELAPSCAEAGVLGVLPGIIGSIQAMETIKLLLGLGDPLVGRLLAYDALEESFRTFKVNRDPQCAACSVPPEQLVIAEYDELCMPHPIAPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNC5</accession>
    <name>A0A7K0JNC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_01215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000043">
        <property type="protein sequence ID" value="MST31351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="487" mass="49919" checksum="57C7682C5B08FA98" modified="2021-04-07" version="1" fragment="single">MIDPLAVAAIVTVGVATVFVGARGLRIARTSADFLVATRAVPPLLNASAISGEYLSAASFLGIASLALSEGLGALWYAVGYLAGYLVLLAVIAAPLRRFGAYTIPDFAEGRLDSPRLRSVATGLVLLICGFYALPQLTGAGITLEDALGLPYWVGVVVLGGIVTVAIASGGMKSITLAQALQYWIKVVALLVPAVVLLAVLRHPALGSLRPDGAARFTRPTVVHVPGREVLVFARSTRVAVTGVLDGVRRHGAVLVTAGRHAVGAGTRIAFPAGPVPHLASRPALDGAAWTSPLVRIDGRSIHPLAATYGVITATFLGAIGLPHILVRFYTNRDGSSARRTTSLVLLLLSVFYLLPGIFAFLGRLEAPGLYVSGRTNGVVLVLPRLAAGGLGGEVLGALTAAGAFAAFLSTTSGLLIAMSGALSHDVLHRGPAAFRWSALGIGAAATACGLAAGGYAISVLVGWAFAIAASSFGPLLVLGIWWRGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNC6</accession>
    <name>A0A7K0JNC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03767 family metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000072">
        <property type="protein sequence ID" value="MST31466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="166"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="505" mass="53818" checksum="91AFF2D296875A7D" modified="2021-04-07" version="1">IVAFLQVSDLHVTDAQSTLRAEWLDRFGDDDSPVRAALGPIGTYRTQESLTTQVVEAMARALRRIDTGPVAGGPIGFTVSTGDAADNAQANEVEAAIRLLHGGSEVLPDSGDRGRWEGVGTTDHYDPRYWHPDGTPTGAEEDRPRSRHGFPLVPGLLDAARLPFAASGVGFPWYPVHGNHDRLLAGTVTVNRFLARLARSGRKSVRLPDRLAPADLVELLGGSELRDLALVPAFADAPFRAVTPDAGRAPLELAGWLAAHDGRSALPATATPWYAFDAGPVRALVLDTVDHEGGWQGSIGAEQLAWLEAELEAASDHWVDAGGRLRHRPGPARPVVLFSHHPLRCLINDWSPTGARRVLADELAAVLARYPALVAWVNGHTHAHGVLPHPRHPALEGGWWEVTTASHVDWPQQARVLELAVDGAGQLVLAATVVDHTGALRPDAGDLGSVETLAGWSRLLAANDWQRVGPDGTVAGRGRPEDRNVILVCAGAPVPSPSAQEAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG2</accession>
    <name>A0A7K0JNG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000087">
        <property type="protein sequence ID" value="MST31510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="SSF56574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="23804" checksum="A0E30808CB5EF83D" modified="2021-04-07" version="1" fragment="single">MPAALGRYARRVHRCAGDGHHVVSPLGAWLLLALCDPLDPGAGPDGLRDALGMEPGEAFEAAGALLADPHPLVALAAAVWARPQVETAAWRRWQAALPGAVGRGDIPSQKGLDSWAREHTLGLVGGFPLRLTPEVVAVLATAVATRVSWEKPFDVVDASELGPDSRWTRALRRVLRSPIGDPRHPQYLCETPGAGLVAVHVADARGGMVVGSVIAADPAVPPGAVLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM1</accession>
    <name>A0A7K0JNM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="75"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="27871" checksum="1D9531A740BC267F" modified="2021-04-07" version="1">MPPVEGGPASGRIQSVSRAVKLLMLVASGQTGSTGKELALAAGLPAPTAHHLLSTLVDEGLLAKDGSARYLLGMKVAVLADALQRAVTAPAYLLEPLRQLAATTGETAYVATWRQGDIRVQASVEGNHPVRVTLPLGPYTNAHARATGKVLLALASEELREAYLVSHPLVALTPRTIIDRQRLEDEFGVIRERGYAIDEGEFQPGVSCVSAPVVDQQVVVAAYSISVPTPRFVERRDWLVDATVAVARNFRPARAGRQGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR8</accession>
    <name>A0A7K0JNR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_02550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000106">
        <property type="protein sequence ID" value="MST31612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="74"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="236"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="380" mass="39177" checksum="A82929ACD082E9EE" modified="2021-04-07" version="1">MRLGAYRRSRPGHGAAGPSGGGRPGRTRGRRPGRTGGRRGGRTRARCPGRPQEGAQIVEGHDGQGRQEPAGGGRIGFVGTGNLGAQIVGRLLAAGNEVTVHDRDPRAAEASIAAGARWAASPAELAAGVDTVMTCLPRPDTVAEVVGGAKGILTTLRPGGCWIDVTTNDVEVLHRMSELAAARRVGTLEAPVTGGVHKAAAGELTVLVGGDAATYAAHRGLLGQVGSKVIYLGPLGQASRMKVVTNMLAFIHLVAAGEGLMLAARAGIDLRDAFEAIRASSGNSFVHETESQLILSGSYDIGFTVDLACKDLGLAAGLASTLGVPTELAAVVRRQFEQARERYGGSAWSPRVVQLLEDETGLSLRAAGFPRSLLDDTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX3</accession>
    <name>A0A7K0JNX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="23914" checksum="C4E807E761984C49" modified="2021-04-07" version="1">MIRAVVFDVGEVIVNETREYGTWADWLGVPRHTFSAVFGAVIASGRDYREVFGEFRPGFDLSAERDARAAAGHPESFDEDDLYPDALPCMSQLRAAGLVVGVAGNQTARAESILRGLGLPADWIGTSAGWGVEKPAPEFFHRVVSEAAVDAAEVLYVGDRLDNDIRPALRSGLQTALLRRGPWGRLLSDPETEQRCLGVMSGLADLPGLVAEHNRLAQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM0</accession>
    <name>A0A7K0JPM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000165">
        <property type="protein sequence ID" value="MST31885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH_5" evidence="1">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31677" checksum="28D9CCB6F36EC84D" modified="2021-04-07" version="1" fragment="single">MAAQDTCPYCGRDLESCGGATDEHIFVEALGGKAILPAGRNCNSTIGHSIEGQLLKQGTLLHFIRQVHQGTGQPLRGELEGGTVIENSLGGADVYFRRPFSQVREENSTTYRITGGTEQARRELEKLAKHLKLSPEETQALWSKREVRSLGGQTLQVGLAYDVALVRRLAAKVGLSAGWAAFGDRFAESELASRLRDFLWGDGDMEAPSCSGEILTVFDEQVIADKLVKQGVAGISPIQASDGVSQVAFVPIRQGVAVIVTLGDWELSFGATTAPLIEAPLPVGGRLPVVIRDGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN6</accession>
    <name>A0A7K0JPN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_04145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000174">
        <property type="protein sequence ID" value="MST31918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029717742" description="GH26 domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="5">
        <location>
            <begin position="11"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="205" mass="22000" checksum="ADA83F41A0EEE9EF" modified="2021-04-07" version="1" fragment="single">MMRAVVGSLVVAVAALLTTVVTTSSPAPRTTPLTLYVGPGAPDALRRAAAALDARPTRAADFFNGRSWATLTNPYTERPWTHSGYQMIWGIPMLPASGASLRAGAAGRYDRYWTTMAHQLVAARQAHAILRLGAEFNVPGHPWYAGGQAPAFVAYWRHIVRSMNAVRGAHFAYLWNPNIGGGGPVDAAIGDLGAYYPGNTYVEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS9</accession>
    <name>A0A7K0JPS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000181">
        <property type="protein sequence ID" value="MST31945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="324"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="463"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="655" mass="69703" checksum="600248D18C404FDA" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT6</accession>
    <name>A0A7K0JPT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="13749" checksum="54E4A95383E84425" modified="2021-04-07" version="1">MVAQLAPAVDGVRLTIHVVAAAIWVGGQITLAGLVPTARRIDPGAPRLLARAFARLSWPAYGVLLATGAWNVVAVDRGQSGAWQVVLAVKIAVALLAGLGAWLHGRSRSTASLAVWGAVGSLASLAALGLGVFLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV7</accession>
    <name>A0A7K0JPV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_04265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000179">
        <property type="protein sequence ID" value="MST31941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="104"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="190"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="309"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="382" mass="38367" checksum="46F311465C0C3C29" modified="2021-04-07" version="1">VLPTPGVAARSAALGVPAAVISASHNPFPDNGIKLFAAGGRKLEEETEARVERRLVELLGAAGGGAGGQERRTGRSVGTTSVDDSAAAWYGEQLVAALAGRDLGGLTVALDCANGAASAVATAAFTAAGAQVVVTLADRPDGTNINDGCGSTDPSGLAAAVVEYGAALGLAFDGDADRVIAVDGGGRVVDGDRLLALFAADLRARGALAADTVVVTVMSNLGFHKAMAAAGIAVHTTDVGDRNVLAALEANGWSLGGEQSGHLVFREQATTGDGIRSGLLLADLVVRAGRPLADLAGAAMESLPQILRNVPVADRAGLAAAPAVWEEVAAVEAELGADGRVLLRPSGTEPYVRVMVEALTVERARAAADRLEAAVRLALPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB0</accession>
    <name>A0A7K0JQB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_05250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="29459" checksum="53E4D4B0D4EEC1CE" modified="2021-04-07" version="1">MTTTARPLAPSATGIAGRVGDVWAMTRRNLVHISREPMQLSDVTIQPILFTVLFVYIFGGGIPIPGGGSYKDFVLAGLLALNLTTSTMGTAVGLSTDLHGGIVDRFRTLPMWRAAVLVGRSMADLLTAALCALIVALTGLAIGWRSAAGPGALLGGFLLLLLFSYALSWVSACVGLNSKSPESAASFGFVVLFPLSFVSNAMVPTQHMPGWLQTIADWNPVSAVTAGARRLWGNPDPSATVHAWPMQHPIEASLLWSVGILVVAAPLAAYFFRRRTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD8</accession>
    <name>A0A7K0JQD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_05255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="325" mass="34230" checksum="0E8592214CB424B0" modified="2021-04-07" version="1">MPTATIEADALSKRYGSTEALAGVSFTVEQGTVLGVLGPNGAGKTTAVRILTTLARPDAGRATVAGHDVVADAAAVRRHIGVAAQDATLDGLLTGRQNLVLIGELSGMGRRASRRRAAGLLEEFELDHAADRVVKGYSGGMRRRLDLAASLMTSPPVLFLDEPTTGLDPASRLRVWESVRQLIRSGVTLLLTTQYLEEADALADRIVVIDHGRVIADGSPQQLKEQTRGARLEVTLTSASSAAADAMALLASGPVEVSADGRRLSAPVDGTSGLASEVVRSLDRAGVRVDDIAVRRPSLDDVFFSLTGDHLDSEEPNPELDEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX6</accession>
    <name>A0A7K0JQX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="26945" checksum="C7D65CE3E5963C39" modified="2021-04-07" version="1">MNLEGTSALVTGGASGLGEATVRALAGRGARVVVLDMQDDRGEALARETGGVFAHADVTNTAEVIAAVDAAMEMAPLRSVVNCAGIGWATRTIGRDGTYESAHDLDVYRKVIEVNLIGTFNVSRLAATAMSRTEPLADGERGAIVNVASLAAFDGQIGQAAYSSSKGGVVGLTLPLARDLAVVGVRVNTIAPGLIDTPIYGYGGNAEEFKEKLKRDVLFPDRLGRPEEFASLAVELLANSYMNAEVIRIDGGARLQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR02</accession>
    <name>A0A7K0JR02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000279">
        <property type="protein sequence ID" value="MST32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="29791" checksum="22AE6A81AFDA2A57" modified="2021-04-07" version="1">MPLWSQLLEDLRTRLKAGEFVRDFPSDIELTRHYGVSRQTVREALRRLQQEGVIERGRGRGSFVRERPIEQHLGTLYSLFRSVEEQGFVQESVVRSLAVGRDEEAAAMLDCRPDEPLVHLERLRMADGRPMVLDSSWLPARLASPLLEADFHRTALYRELELRCGLRPDAGWERVLPVLPTPEQRKLLGMGARAPAYGVERLACQGRLPVEWRHSVIRADRFSFVARWEDGRVDAAFEPPSRSEGRPATPPPGGGAPAGRGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR51</accession>
    <name>A0A7K0JR51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000282">
        <property type="protein sequence ID" value="MST32383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10707" checksum="0F6798CDA937A4F3" modified="2021-04-07" version="1" fragment="single">MTHTLDPATTDAERVRHDDRAHVFHSWSAQELIDPLPIASASGSHFTDYDGKRYLDFSSQLVNVNIGYQHPKLVAAIAEQAGRLCTIQPAFANDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR84</accession>
    <name>A0A7K0JR84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000298">
        <property type="protein sequence ID" value="MST32456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="51"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="472" mass="51564" checksum="E0B6A7725D7F529F" modified="2021-04-07" version="1">MSAVTTLTGSSSAAGRRDGGWERAAPISFWMDDPAAPPPLPPLDRPLHTELAVVGGGFSGLWTALLAKQADPGLDVVLLEGERVAWAATGRNGGFCEASLTHGEPNGRNRFPDEYEVLARLGQDNLEAIDAFVRQRRLDCGWERTGTLSVATEAWQVDELRGGGPQPEDWLDAAALRAEVDSPTYLAGRWDRDGGAIVNPARLAWGLRDACLEAGVRIFEQTTVEGLERSGRAVALATAGGQVLADRVALGTNAFPSLLRRVRPRIVPVYDHVLMTEPLSDEQLGRIGWRNRQGIADAGNQFHYYRLTTDNRILWGGYDAIYHFGKQVRPAYDQRPATFRKLARHFFETFPQLEDVGFTHRWGGAIDTCSRFCAFFGTALGGRVAYAAGYTGVGVGATRFGAQVMLDLLAGARTERTSLQMVRSKPLPFPPEPLGWVVIEATRRSIAAADAHEGQRNAWLRLLDRIGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB1</accession>
    <name>A0A7K0JRB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000303">
        <property type="protein sequence ID" value="MST32470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="10470" checksum="B695954F206FA637" modified="2021-04-07" version="1">VYGPQRLADPPALLAGFRERLADALRDGYTGLRVVADNSAMLDGPERVAAWRRWEPVADMFMAAYPVTGVCAFDDERVDPETLSDVLALHHPTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB2</accession>
    <name>A0A7K0JRB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000304">
        <property type="protein sequence ID" value="MST32475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="21281" checksum="621A3E8939321462" modified="2021-04-07" version="1">HTWRELTTVLHEGVPGHHLQTVVAMRAPGLHPWQRMLAHVHGHVEGWAHYAERLAGEIGLLPDPGDRLGMLFGQRWRAARVVIDLGLHLDLPIPAGNGLTEAGRWTPEVGVAVLRAASGADEASARVEVDRYLGWPGQALAFRVGARSWEAIRLEAGARRPLDRRAFHMRVLRLGTMGLGPLRSIAAEELDGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG5</accession>
    <name>A0A7K0JRG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000325">
        <property type="protein sequence ID" value="MST32538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029703277" evidence="3">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="338" mass="33852" checksum="5A2789538D231DF8" modified="2021-04-07" version="1">MHVVAAVVLAALTSVANAASATLQWHATSNAPCELQGIGLARHLLRRREYLLAVGALVVSFLLQAAALHEGDLALVQPLLVLELPFTLLLASAWLGVGLDRREVLGAVAIGLGLALLLGAGAPHGGRVGLPAGAWLMTAAVTVVVLALLVIGSSGSGPVRRAVLLSAAAGVEFSVTALLVKAVTDRVGGGLGHLLLGWPVYAMAAAGILAVLLQQQGFRAGPIAAAKPSTTIATTAGSVVIGLLVLHERLRGGVALLPELVGVAVLLAGIIELARSPLISDGGRPEPVSVPVGAQGEPPVIDLRPAPGPSAGTTPPDDRPAGVRSRGGPSPAPCKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI2</accession>
    <name>A0A7K0JRI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">smpB</name>
        <name evidence="4" type="ORF">GHK86_07455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000330">
        <property type="protein sequence ID" value="MST32558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="18364" checksum="58701181D60822F0" modified="2021-04-07" version="1">MAPKRPGKTAGPRAVATNKRARYDYDVLHTVEAGIVLVGSEVKSVRDGKVQLRDSYARVHNGEIWLHGVHVAPYAYATGFGAVDSDRSRKLLLHHRQIAELGIRTTQEALTLVPLSIYFKDGRAKVDLALVRGRRRYDKRHAIAARDADMEARRAARGRQRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP9</accession>
    <name>A0A7K0JRP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_07730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000342">
        <property type="protein sequence ID" value="MST32611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="48"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="365"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="607" mass="64864" checksum="0A90A53D96915AA3" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ7</accession>
    <name>A0A7K0JRQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000337">
        <property type="protein sequence ID" value="MST32593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="391"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="621" mass="68930" checksum="B39615F888D42C55" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ8</accession>
    <name>A0A7K0JRZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000364">
        <property type="protein sequence ID" value="MST32697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029759783" evidence="1">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="18323" checksum="5EA70218904DC5EC" modified="2021-04-07" version="1">MNIGKRAILPLLASGGMAAALFGGGAVHTAFTSSGSGTLNVNTAKIGTAVSGNVALSNAVPGDLGPTSLVTVTNNGSTPETLAVSLAPTGNPSQNNAALDQYVEVYFGGNPIGNLATLEADYGTGHAVTIPGANLAAGGSVSYKIALGLDQNAPNSVADSFTEAVFTVTGTATTDPASGNKAGGDNSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS39</accession>
    <name>A0A7K0JS39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ORF">GHK86_08535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000383">
        <property type="protein sequence ID" value="MST32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="12159" checksum="55033C308EE1E9FE" modified="2021-04-07" version="1">MTTNHVTLTDQTFDEEIKSSGEPVLVDFWAEWCGPCKMVAPVLDEIVDEQAGKLKLGKINIDDNMELARRFDVMSIPTMILFKDGEPQLRIVGAKGKGQLLQELHPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS41</accession>
    <name>A0A7K0JS41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1634 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000281">
        <property type="protein sequence ID" value="MST32379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17770" checksum="DD8BF51BEF2E4DF6" modified="2021-04-07" version="1">MTGTRQPTDPPTPGGPGPGDEGKAPSRRRQLTPEQALLMEEKVRKVEVAISLVLRIGVVLSVAVIAVGLGLMFAHHPDYVAITGRFGYRHLTSRGAPFPHSFAALGRAIGAGEGRGIIVLGVLILILTPVLRVAVGVLAFIYEKDPPMTIVTLYVLIVLVGSFFLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS46</accession>
    <name>A0A7K0JS46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000379">
        <property type="protein sequence ID" value="MST32747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD_C_2" evidence="5">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="8803" checksum="71C78BCF570D6436" modified="2021-04-07" version="1">IAPAALVGAVAAALPGAGVGELGRRVTVLAAEDAKGLEFDSVVVVEPGAIVAERDERAAGLRLLYVALTRPTQHLSIVAAGPLPAALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE3</accession>
    <name>A0A7K0JSE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4365 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025375">
        <property type="entry name" value="DUF4365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14280">
        <property type="entry name" value="DUF4365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4365" evidence="2">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="463" mass="51554" checksum="C9FBAE612889BD22" modified="2021-04-07" version="1">MALIAKRVGEMGYLFHPRRVDHGIDGHIDLVDPSSSELLNLTLLVQSKASTLPFPDETDQGFRYTCDQRDLDLWLGGNAPVILVLSHPDNDHAWWVDVRDAFSSPAARAARVVYVDKRTQVFDTAAAAGLRAVALPRDTGLYLPAAPIQETLTTNLLEVADWPASLHLARTNARDYPEAGKRLQSSGIRAGGWMLRDGFVISFRDLTEAPLNALCDSDVESHATAEWAESSDLDTQHRFMDLLTRTVQDAHPELRWHKERRHLHFLASQDLRPRLAGKGHGNRGRTVFAPHYSKSDPGRVSYYHHAALRLRFRRLAGQWFAQLEPDYCFTSDGSAESRIADSLLAGIKRLDRHPAVAGWTRMWANHLRGGDDLFSPDRIVAFGDLATVTVDRGIDDRWWGPAPAEATIEDERDLQPTASVDASLIAAGVDADELTLLLTGEDRPPQRPGRASQRSRRPQGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF2</accession>
    <name>A0A7K0JSF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000416">
        <property type="protein sequence ID" value="MST32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="43149" checksum="4D61329D0CB987AD" modified="2021-04-07" version="1">MRITDVEAIVVGVPPPHFGGRYWIFVRLTTDTGVRGIGEIYGVPFHPSVVEAMVADIAERSVIGADPFQVERLWRQVYSRGFTQRPDASVVAVLAGIETACFDIMGKETGRPVHDLLGGRVRDAVRSYTYIYPAPGEDEAVYTDAGLAAGRAAHYAGLGFTAVKFDPLAWYSSLDPRQPASRTVAEVARYVGAVRDAVGDGVDLLIGTHGQMTPSGAIRLARAIEGFDPLWLEEPVPPEMPEQMALVARATSIPIATGERLATKYEFARVLECRAAAIVQMAVGRVGGILESKKIAAAAETHYVDIAPHLYAGPVEAAANLHLAAATPNFLIQESIETMNGFAAEILRRPLQWDSGFLVVPDEPGLGVELDDDAVARHPYEGRLLHLEMGDREEWSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI9</accession>
    <name>A0A7K0JSI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000324">
        <property type="protein sequence ID" value="MST32534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="71"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="27397" checksum="3683934D821A75E6" modified="2021-04-07" version="1">MAEGEGGLRSLDKALLLLEVLAMADEPATAQELARRGQMNRTTVWRILGTLERHGLAHRDPDSQRYTLGVAALGLGGHGREQSLVRLAHPPLAQLVERTGLVLSLAAPRGLELVYVHQVDPPSLAMPPNWVGRPVPLHATATGKAFLAALPPPELDAVLGAQLQRFTDTTVTARRQLLAELENVRAAGYATARGELEEGVHAVAAAVLDRNGIPVAVVNLWGAPSTVDQGTVELGRRTTQAALEIRRLLNDGARHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV7</accession>
    <name>A0A7K0JSV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000338">
        <property type="protein sequence ID" value="MST32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7602" checksum="1614631427247534" modified="2021-04-07" version="1">MAARSEGPEALRHRIDQHLDREEEESFPASDAHGDWAGPPLWLPAVAESGEAGGPPGDADRPDPTTARHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW5</accession>
    <name>A0A7K0JSW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000467">
        <property type="protein sequence ID" value="MST33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="485" mass="49720" checksum="D7CDE7C64F1E0E73" modified="2021-04-07" version="1">MADSYPGAAALVVCSLIPYLALTAAVFPLAHVLAGSLGLSLSTLYITISVSTGGYAMGTVLALQFAVHLPARRMLVVYEVIFFLAAVLTAWAPTGAVFIGGFIVLGLCTSLMLIAAVPPLVTSWPAVKMPVTGGIMNLCIFGAVAAGPTLGAIEAASGTWRPLFWGVAAIAALALLFSLLTFQDAPPVDRSSPWDLVAVGLAVVGCGAAFFGAGELQASAKADVLSLVPLVGGSVALVVLVVYEYRLRNPLMPVRAAATTAPVTGIWTALTASAASFGVMELVLETLQKTTTPTRAALLFIPEFVAAAVVAVVFAVLFRTRYTPVLALGGLLAIAAGAGIVLAVVPAPSVLIAAATGVLGLGVAASVSPGLFMAGFSLRSAQLQRVFAMIELMRGVTAFLVAPILVYLAGFLGSSPAAGTDDALWICVGIAGAGFVGGVLLYVTGKGRLQAPDLERWQEEGEQAWDSPPLLGRVRRREQEAVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ3</accession>
    <name>A0A7K0JSZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000467">
        <property type="protein sequence ID" value="MST33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="24970" checksum="086C113D52A106B6" modified="2021-04-07" version="1">MTAGDEPLVAVARHGAVAVVQLHREAKLNALSAELEGQLLDAVRGPEVTGSRAVLLTGGDRVFSSGADVTELAGRSPAEVFAYYRSTGHVYEEVAGLPQPSVSAINGYCLGGGLELALATDFRVAAADAVFGFPEVGLGIVPSSGGLHRLVRTVGVARARELVLARPRIGAPEADALGLLTEVCAPGVDPLVRALELAAALAALPPLAASLALQAIDAAGEASREAALLIERLCYATLAQQPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ5</accession>
    <name>A0A7K0JSZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="351"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="440" mass="46389" checksum="F6A59C895BCF843C" modified="2021-04-07" version="1">MRSRASRSVGRRPARKAWRCRPCEPQIVPASKRAKHGVGRRQEWSGLPFAAPVGHDPEDGQGAQTGRSLADQAVAKRTGAMTVSGDLPGSAAPTLGAGATSDALHSVRSDVGQDANAEMTGFALVLVAADGTVRSCNRAAELLLSCRAVDVVGQAVTTLEPEGQRGELARAIGRVRAGEDAVHCETAWGREGRRNVPVEVTVLALRWRSRRTVGLAVVLCEAGERYPVGHEPVRSLREHDQLKLASERERIGRDLHDMVIQRLFATGLALQGLANLVAPPEALRISAAVEELDLAIGDIRTAVFALAHHRARVSSSLRGRLLEVSAAAAGGLGHDPTLRMEGPVDTSVSGEVGDHLVAVLTEALSNVTRHAHASRTDVLVSVDGEIVLGVTDDGVGVGNPARSSGLHNMRQRAEALGGTMLITGVPAGGTALEWRVPLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT37</accession>
    <name>A0A7K0JT37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000489">
        <property type="protein sequence ID" value="MST33112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="15742" checksum="4C2E4EFAAB6C6C6D" modified="2021-04-07" version="1">MTMGRISGSFYGIGADVARTKVGRPVFLGSVQGTRVSLQRPSRSNRAIVPRLVGRLEPLPEGGTMLTGRMRFGLLPVVLFAVIVSAMLATQLPSLLAGVGWGAGMLLVLLVLREFVSWGPDRSYLNDALASQADLVPYDDDAEVPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT38</accession>
    <name>A0A7K0JT38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000475">
        <property type="protein sequence ID" value="MST33083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="115"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="37810" checksum="B483FE98CABD881A" modified="2021-04-07" version="1">MLDGWVVQQRSRMLAGHTVDQRVLVVRRFLGFTSDYPWKWSPSDVEEWTAELVGRGLSHSTVRNYQQAVALFCGYVADPRYRWGEVCEQRFGAAPVQVFHEWNTVVHRSDFEGRPGNRPLSREELQAFFDYCDAQVSRVHATGRKGWLAAFRDAVLFKTIYAWGLRRREAAMLETVDWSANASAGEFGRFGALSVRYGKAMKGSPPRRRTVLTTMGWAAEAVAEWVEEIRPAYVQAGLAMWPTERGGRIAVDSLSHRFVAYRDALGLDEHLGPHCLRHSYASHLLEDGFDHLFVQQQLGHSWGSTTAIYTSVGTDYKNRALRRALDRAFPAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT86</accession>
    <name>A0A7K0JT86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit NuoN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuoN</name>
        <name evidence="8" type="ORF">GHK86_08390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000374">
        <property type="protein sequence ID" value="MST32739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="189"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="535" mass="55168" checksum="6505E3576EE23F32" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD5</accession>
    <name>A0A7K0JTD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtI</name>
        <name evidence="5" type="ORF">GHK86_08650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000390">
        <property type="protein sequence ID" value="MST32789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="465" mass="49977" checksum="1A8E8CF6DAE3C1D7" modified="2021-04-07" version="1">RAGGPGGRAGRWESAGYAVDTGPSVLTMRDLLADTFAAAGADLADHLRLSAVDPMYRAWFPGAGPISVRRGREAMTEEIRATCGPADAAAFGRFADWLGRLYRVEQPGFIARNYDRATDLARPLLPALRLARLGAFRRMATVVDGYFADPRLRQLFSFQALYAGLSPFDALAIYCVITYMDTVEGVWFPEGGIHAVARGLADAAAKAGADLRYDAPVARIVRRLGSSGPVTGVRLADDTFLPADAVVANPDLPAVYRELVPSARMPRAARRGTYSPSCTLWLAGVRGRLPEGAGHHNIHFGSDWKGSFDALLRAGTRQPDPAILVSAPTVTDPTLAPAGGHVLYALEPVPNLDGRIDWASDRARFRDTLVERLARAGYPVGAADVVTERFVDPLDWEAQGMERGTPFALSHRFFQSGPWRPANRDRRVPGLVLVGSGTVPGVSVPMVLVSGRLAADRVDELAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE8</accession>
    <name>A0A7K0JTE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metal-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_10800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000523">
        <property type="protein sequence ID" value="MST33207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="23806" checksum="5BEE1C0323D02E3A" modified="2021-04-07" version="1" fragment="single">MGSGKAVWRISRAPGGDGSARTGDLAGSLRVSPGTVTATVKRLAERGLLTHTPYHGVELSREGERLAMQVIRRHRIVERFLADLLGYSWAEADALAPTFEHQLPQEVEDRLFVALDRPTTCPHGFPIPGEGSDTLPQLAVLYDLTPGERAVVALPGSTAPELARFLDGLGVRPGVEVVVREKQPFDGPVVVAVEGEDRTLGAGVARQIFVRHLTAAVEGPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF3</accession>
    <name>A0A7K0JTF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ORF">GHK86_10880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000526">
        <property type="protein sequence ID" value="MST33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="313"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="383" mass="40523" checksum="7C9229740CB60C45" modified="2021-04-07" version="1">MDLFEYQGKQYFARFGIPVSAGGVADTVEEAVAAAEAAGYPVVVKAQVQVGGRGKAGGVKLANDAEEVRLHAGNILGLDIKGHLVRRLWVEHATDIAEEYYASFTLDRGAKAHLAMVSAKGGVEIETVAEEDPGAIARLHVDPAAGFSEAQARRLVEEAGLPDAAREGAVAILQQLFRCYEEGDADLVEINPLVLTTEGRVHALDAKVTLDDNAAFRHPEWDEYRDIDEFDERERLARSKGLQYVGLDGEVGIIANGAGLAMSTCDVVNQVGGSPANFLDIGGGANAEVMANALEVINSDPKVKAIFINIFGGITRGEEVAKGIVTALGRVTIEAPIVIRLDGTNAEEGREILKGVESDRLISQPTMLDAARKAVSLAGGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH2</accession>
    <name>A0A7K0JTH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000534">
        <property type="protein sequence ID" value="MST33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="15776" checksum="580708A8685E4801" modified="2021-04-07" version="1">MTTWMEHAQDIFSAAVGVVLVLLAAAILVDGVARFLLDLGHVSVVVAATNLVDKVLLVLILVEIVHTVVLSLRAHELVAEPFLVVGLVAVIRKILFVLSSSQALGTGRLAVYLGLVAVFVAGLVAVRLADRRQGVLVSQPGGVEAARSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTK7</accession>
    <name>A0A7K0JTK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000545">
        <property type="protein sequence ID" value="MST33281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="207" mass="21577" checksum="A0E86C86EDF96B83" modified="2021-04-07" version="1">MADVLADEVVAGDGGRVARVVIDPVGRVLTHLVVVPDGAALGRLVPLALVADPGPPVRLTCGRSELMALEEAEETHFFAGEPSSGYAGDQVLVWPYLGLGGVNGLGAPGVGAVPPVVYDRVPLGEVEVRRGDPVRASDGDIGRVRGLVVDPADRHVTHVLLEEGHLWGRKQVALPVSAVRRGDDGGLEVALRKEEIRDLPPVDLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP3</accession>
    <name>A0A7K0JTP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-3B C(17)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobJ</name>
        <name evidence="7" type="ORF">GHK86_09570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.131" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="27861" checksum="8FEF34CECA0A84BE" modified="2021-04-07" version="1">MTFPRGRLAIVGLGPGGAPWRTPAADALLTEATDLVGYTTYLDMVEARPAGQVRHRSDNRAEGQRAAHALDLAAEGRSVAVVSSGDPGVFAMAAAVMEQLDRPDRPASWEDVEVIVSPGVSAAHAAAARAGAPLGHDFATISLSDNLKPWSVIESRLAAAAGADFVLALYNPASRHRPFQLGRALTVIGAHRRPDTPVVVARDIGRPAERVDVVPLADLDPAVVDMRTVLIVGSSQTRMVDVPGWDRRGVYTPRRYPEVSADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS2</accession>
    <name>A0A7K0JTS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000449">
        <property type="protein sequence ID" value="MST32994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="230" mass="24393" checksum="CCACB890559AF463" modified="2021-04-07" version="1">MPDNPKQNVTFPSNGGEAHGYLAVPAGGRGPGVIVIQEWWGLTDHIADLTDRFAREGFVALAPDLYGGRTTHDADEAGRLMQELPVEKASQDLRGAVDYLLGHEAVTGDKVGAVGFCMGGGFVLSLAAQAGDKLAAAVPFYGVLQTEPDWSGVTAKVQGHYGEKDDFVPMDAADAQFQAIAAATGTQPELHFYPAGHAFLNDQNLLGTYDAEQARIAWDRAVAFLHAQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW5</accession>
    <name>A0A7K0JTW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2520 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000575">
        <property type="protein sequence ID" value="MST33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2520" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8354" checksum="B146488BFEC9D4E4" modified="2021-04-07" version="1">ATLGQVARLAEAAGLRLEDFLPLARAALDDVARRGPEAALTGPVARGDWSTVARHLAALPPDEHAGYLGGVALALRLAGGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA4</accession>
    <name>A0A7K0JUA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_12455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000628">
        <property type="protein sequence ID" value="MST33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="365" mass="38362" checksum="77B9CC342FB19412" modified="2021-04-07" version="1" fragment="single">MTLLRSTAPTPGRDPGRRDAAAGESRGRNRWAIFAIVSIALFMSSLDGTIVATGLPTIRHALHTRLNWVSWTMTAYQLGLVAAMPVTGRIADIFGRKRVFVTAAVVFTGASLACGSVDRIDFLIALRVAQAVGGAAFLPAASGMVVDAFGKDRHRALGLFSSIFPLGALAGPIFGGIILTDWTWRGLFLVNVPVGAVFTVLAVRYLPGSPPRPGRADLLGSLLIGATVLATMLAITDAGERGAALWSWRVLLPAALAVGCGWLLVRRAGRVADPVIPLRLLRGRAFASMNALNFVWGACVIGLGSLVPLVAEERYHLAPLPAGTLLTTRALSEIGVAVVASLVIHRTGFRLPIVGGITLITTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF0</accession>
    <name>A0A7K0JUF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">zwf</name>
        <name evidence="9" type="ORF">GHK86_12710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000646">
        <property type="protein sequence ID" value="MST33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="165"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="457" mass="51382" checksum="C0F78D0BE509E1A1" modified="2021-04-07" version="1">RKLLPGMLHLSEAGLLPDYRLVGVATDELDDESFRELARHACEEFARTEVTDSRWSDFGKRLSYVPTSSGAPGLHEVVDAHEAELGGRPRRLHYLSIPPTAAGSVVRTLAAADLVERSRIIMEKPFGTDLASAQALNATVHEIFREDQVFRIDHFLGKEAAQNILAFRFANGLFEPIWNRDHIDHVQIDVPETLSVADRAGFYEETGAFRDMVVTHLFQILAFMAMEPPTALEPRAISEEKNKVFRSMRPLDPRHVVRGQYEGYRHTPGVDPRSQTETFVALQVEIDNWRWAGVPFFLRTGKQMAEGARIISIAFREPPKSMFPTDSGVGTQGPDHLTFDLADSSKLSLSFYGKRPGPGMKLDKLSLQFALHETGREADVLEAYERLIHDAMVGDHTLFNTAEGIERLWEISSPLLADPPQVLPYWSGSWGPSTIDELIAPRTWRLPFRRGWRSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI1</accession>
    <name>A0A7K0JUI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000660">
        <property type="protein sequence ID" value="MST33607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="17957" checksum="1E671D7CDF2CB962" modified="2021-04-07" version="1" fragment="single">MSLRRLGRAVMHGGDYDWGIGITAGVIALLALIGGSNFGRIADYGTVKIHHPTLRDVLVSAGSALTILVFGVIATVRISSAVGSSAFVRAMPSAAAAVRLFVSGVGYLICAFAMLAVLDVGVGKLLVGAGLAGVILGIAAQPSLGNVFAGLVLVFARPFTIGDHIRIRSGALGGIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI2</accession>
    <name>A0A7K0JUI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000664">
        <property type="protein sequence ID" value="MST33616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="109"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="374"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="518" mass="54484" checksum="C13D8AB282880D94" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN1</accession>
    <name>A0A7K0JUN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ORF">GHK86_11155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000541">
        <property type="protein sequence ID" value="MST33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17955" checksum="AF3C3187A7078C05" modified="2021-04-07" version="1">MRTALFPGTFDPFHNGHLEIVETAAKLFDHLVVAPMRNPQKTEALFTLDERKAMIADTVAHLPNVTLASFSSLVVDLAREVGADVIVKGLRVVSDFESELQQAQMNKAVSGYETLFIPCSSESTFIASKYVRDFAHFGGADRIGSMVPAPVLAMLKAKFSGNGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR6</accession>
    <name>A0A7K0JUR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">GHK86_13340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000694">
        <property type="protein sequence ID" value="MST33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17357" checksum="BA1B55EBD220FD1E" modified="2021-04-07" version="1">WAAVGGPVAAAAYRAVNTLDAMVGYRNDRYRRFGWASARTDDLANFVPARVAAATVALCSPGHAAAIGRAVRRQAPAHPSPNAGVIEAAFAAALGVRLGGANRYGELVEQRVPLGDGRATAPGDIARARLLARRITVVAAGALASPLLLEQWRRSRTTRRPRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUS2</accession>
    <name>A0A7K0JUS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_13355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000694">
        <property type="protein sequence ID" value="MST33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="407" mass="43645" checksum="92113479FB910D58" modified="2021-04-07" version="1">MSHRAGPAGRGPRPPALFRQLRGTLSGAKWGRLALMFVSILAVNALGWLIYVAVVLPRHIDYRGYGGTKGLGIGLGVAVTAWFLGFRHAFDADHISCVDNTTRKLMADGKRPLATGYFFSLGHSTIVVGVGVGVTFAARAVFGAVVNPSSAYETAGGAAGTVVSASFLYLIAVLNLVVLSGILKVFREMRRGTYDEAELEAQLQSRGLMYRFFGRFMRSINHTWQLYFVGMVFGVGFDTATEVVLLAATAYAAIQGLPYYAVLALPFLFSGGMMLFDTLDGCFMNFAYGWAFAKPVRKVYYNLVITGLSIGAAFIIGTIEILGVLTNEVHLHGTFWETMANFNINVAGFCIAGLFVVVWAGALAYWRWGNVEARWGAEVAPAVPPPSPSAVGDRQPAPGSAAAGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV48</accession>
    <name>A0A7K0JV48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000593">
        <property type="protein sequence ID" value="MST33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="35316" checksum="75A82D7ABAC12375" modified="2021-04-07" version="1" fragment="single">MPHPDVAAEQAHVDHAYARLDEMRSTVAGMLKDAFGERGGTFQALTERDIRVRNSLGRLEQLQIGAEALVFGRIDRRGATPAEDEAFHIGRLAISDADQEPLVVDWRAPVAEPFYRATGAHPMGLARRRHFLTEGRSVVDLEDELFGVEGDDDGVGLGLSGPQVLLSALQRSRTGRMRDIVATVQREQDEIIRGPLGGILVVQGGPGTGKTAVALHRAAYLLYTHRFPLERQGVLVVGPNPTFLRYIEHVLPSLGESGVELSTVAGLFGPVGRLGTEEAEAARLKGDPRMGRVLARAVADRERRLRRVVEIPFGRAILRLTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA5</accession>
    <name>A0A7K0JVA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rho</name>
        <name evidence="10" type="ORF">GHK86_14240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000757">
        <property type="protein sequence ID" value="MST33873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="9">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="210"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="457" mass="49804" checksum="D5612E5EB110A9B3" modified="2021-04-07" version="1">DRPRPEARNGAAQQGGGHQQGGSHLQAGGHQGGEEGGEGGRFDGEPGNRRSRRRRGRDRAERTERELPGQAPEQAFSGEPEPVSGLLDLREEGYGFLRTTGSVPGPSDVYVSISQVRRFALRRGDRIEGAARPAGGNEKYPALVRVDTVGGLTPDEARNRPRFDTLTPLFPDQRLRMELPKDADNVTARIIDLVAPIGKGQRGLIVSPPKAGKTTVLKQIAHSIESNDPDVVLIVLLVDERPEEVTDMRRSIRGEVVASTFDRPAEEHTQVAELTIERAKRMVEVGKDVVVVLDGITRLARAYNLAQPAGGRVMSGGVDAGALYPPKKFFGAARNVEEGGSLTILATALVETGSKMDEVIFEEFKGTGNMELRLDRRLAERRIYPAIDVTGSSTRHEELLFGREQLQQVWKLRRVLTALGGDGNHAAGLELLLDRLRATRSNEDFLADLARNPVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC8</accession>
    <name>A0A7K0JVC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000766">
        <property type="protein sequence ID" value="MST33906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="9998" checksum="F14AEBF69BDDDB3C" modified="2021-04-07" version="1">MTQRYVSPLDDRVRTPEPLATRPAGIEGLHVTLLDIRKNRGSELLDTMEELLRDAGATTSRAAKEIFSKPAAAQVIDEVAARADLVVEALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ8</accession>
    <name>A0A7K0JVJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">GHK86_12745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000649">
        <property type="protein sequence ID" value="MST33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="204" mass="22192" checksum="76FAF57E9322610A" modified="2021-04-07" version="1">MAHRSLPDVSAQVSGGDRSADVYQRLLRERIVFLGTQVDDTSANLICAQLLLLAAEEPERDIQLYINSPGGSVTAGLAIYDTMQFVPCDVSTVCMGLAASMGQFLLCAGAPGKRFSLPHSRILMHQPSGQAQGQAADIAIQAEQIIYLKRMMAERIALHTGQPIERIEADSDRDRWFTAEEAKEYGFIDQVIERAADVSAPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN8</accession>
    <name>A0A7K0JVN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000811">
        <property type="protein sequence ID" value="MST34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7946" checksum="2F99D96F7BE3CBDB" modified="2021-04-07" version="1">MARRRRELTETLVTRRVELGLSQTEVAARMGTSQSAVARLESGTADLRLSTLERYAAALGQVLDWRLEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS1</accession>
    <name>A0A7K0JVS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000666">
        <property type="protein sequence ID" value="MST33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12518" checksum="C886FEA43FEA65B0" modified="2021-04-07" version="1">MAELVVEGDELVLHLGRAEKLEAVHGDLRAPRSAVRSVEVLEDAHEPADHGFKVGERLPGYSEVAVVRTGSQKLFAVVHHDTPRGLRIDFEGADYDAWIVGSADPEALKASVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT9</accession>
    <name>A0A7K0JVT9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="9" type="ORF">GHK86_15225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000833">
        <property type="protein sequence ID" value="MST34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="89"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="22861" checksum="01D807DC3E6B44BB" modified="2021-04-07" version="1">MYASAVQDLIDELGRLPGVGPKSAQRIAFHLLKLPSEDALRLAAAINTVKSRVSWCRRCFNIAESDRPGAEAAPTTECDICRDERRDATVVCVVEEPKDVVAVEKTREFRGRYHVLQGAISPIDGVGPEQLRIRELLARIGNEGVEELILCFNPNIEGDATALYLSKLLQDLPVRVTRIASGLPVGGDLEYADELTLGRALEGRREVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW2</accession>
    <name>A0A7K0JVW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000693">
        <property type="protein sequence ID" value="MST33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5348" checksum="853D8A5D04C444F6" modified="2021-04-07" version="1" fragment="single">MVVRGTVLVDVEAALELEVEPAPELDVGCGPVVGLDPAAPEAALAGWVAEPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY5</accession>
    <name>A0A7K0JVY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000858">
        <property type="protein sequence ID" value="MST34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="42780" checksum="0EB4AF2F2BFC22F1" modified="2021-04-07" version="1">MRRSDLRRLEAALARVTGEAVAEHDVADADHVVAALEAATGRLVERSERTEEVASRLAAALHMLVVGVVICNEHGEEVYRNLAAGTSGTRLNDVLAERAVIELLEAAREGRCAERSLELYAPVRRNLLIRAYPISSLGRPLGAVAVVEDVSERRRLDAIRRDFVANVSHELKTPVGALSLLAETLDGEEDPEVVARLSTRVAAEADRLGRIIDDLLDLSRIEANDRPVLQPVPVHQIVQDAVEPVLPAAVTRNIAVQVEPVPPHLTVNGDRRDLVSAVANLVDNAVKYSEPGSPVRVRVAATPEAVSIDVIDRGIGIPSRDRERIFERFYRVDRARSRLTGGTGLGLSIVRHVAANHGGEVRVASEEGEGSTFTLLLPAGAGANGSGAGGTGRQGGNGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW03</accession>
    <name>A0A7K0JW03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000703">
        <property type="protein sequence ID" value="MST33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="88"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="34044" checksum="2E344534C70D1A03" modified="2021-04-07" version="1">MAVRTALDREASWRPRWFWGALAAPGGLWMLLFFLVPFYVVVCIAFGGIDPLFRTPKPAWDPLFWTGNNFSFTWQELTGRLAFLGAPILRTIWYTAAASILAMLIGYPVAYFVARYGGRRKALYLVALIAPFFVSYMMRMLAWIDLLQVNGYVNSIIHAFGLGRVNWLDGKPITVILGLVYGYIPYLIVVLYAGLDRIDERHLEAARDLGLNRTQTFVHVTLPLSRPTLLAGGIVTVLPMLGDYYTNQLLSGSPHTTMIGNVIEGELGNPLLVGQGGALSVLMLVVLLIPLVYYVRQTARASAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW27</accession>
    <name>A0A7K0JW27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000870">
        <property type="protein sequence ID" value="MST34148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="22499" checksum="5CB98169682B7F1A" modified="2021-04-07" version="1" fragment="single">MSTFTLPVGRSDTAAFDTAAFDEPLPRGVGVVWVLVWCNVLTYSPEVSTLVHIPSVVGKALTQGCLVAAAVLALGLNGRGVIRRNTMLLLWSVLAATSLMMSLRLVGVGTTYRGFRLVAFVAVLWLLTRWFGEEEMVFVRLQRRVLLGIVASAALGFALSPSKAFGAHHRLNAVIWGILPTQLAHYSAELAGLTLILWACGLLRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW45</accession>
    <name>A0A7K0JW45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000888">
        <property type="protein sequence ID" value="MST34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="145" mass="14539" checksum="BD79E70E0649F444" modified="2021-04-07" version="1">MVDVGADRRGTSVCLVERDPAALRLLAGVLETAGLRVVGAAGSAAAAVVAVERSRPDVAVVDTRLPDGRGVQLCRQLTGADPGLAVVLHAATVAPGEENEAERAGAVRLVAKSVRGVELISAIRACDTRPPAAAGSAGGGVTRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW59</accession>
    <name>A0A7K0JW59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="3" type="ORF">GHK86_13765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="294" mass="33076" checksum="EAD827996C8A3C1C" modified="2021-04-07" version="1">MLAPATARVPVGGPGPAVDSARSRGSASGVTSLTYGQYLRLGELLTLQRPLSRPEHHDELLFIVQHQTSELWFKLVLRELGTVCACLAEDRPRPAFKAVARVKTVLHSLTDQWAVLATLTPADYAGFRGDLGTSSGFQSYQYRALEFALGAKDRRAMERAEADPLARELLADALKRPSVYDEFLRFLARRGHDVPAEVLDRDVTDSYRFTPPLLPVLRTIYERTEEHWEEYEACEELVDLEDSFRLWRFRHLQTVERIIGTKPGTGGSDGVGYLRAAVDRRFFPELFAVRAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB3</accession>
    <name>A0A7K0JWB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000742">
        <property type="protein sequence ID" value="MST33839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="15084" checksum="C6FC8027235B99AA" modified="2021-04-07" version="1">MLHLGRRRRRRSHPPDRAVAERLPVRAQQTGGADPTLLVVDEAQHVVPGQQTGRFGAARLSFGLRFEVGTDGRKPRCGLLVEPVVQDNVATAGSGYGRPVAAALPEGVYEEPLAVGGTSTVTRKLDHPMLADVFEAASVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH0</accession>
    <name>A0A7K0JWH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_16400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000933">
        <property type="protein sequence ID" value="MST34296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="28942" checksum="9A7678C548BBDB84" modified="2021-04-07" version="1">EFVGTALLVGVGLSIVIVDTSPAGPVVGVLGAGGARALTGALFGTTGALIAVSPVGKVSGAHINPIVTLAFVLRGRMRPWLAAGYVAAQLCGALAGAAALPAWGATGRAVGFGATLPGRSYGPLTACVGEVVTSATLVVLLLAFVGSKRARRFTPLLFPPLYALMVYLEAPLSGTSTNPARSLGPAAVAGAWRGWWVYWVGPIVGALLAIAVSRLHAFRDLEVEVAKVYHFEEDRHGLLHRQRRRGVPVSPRRRPPARSTRRDRASRRPRRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ5</accession>
    <name>A0A7K0JWJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-CoA:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.122</ecNumber>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_16555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:23472"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:18195"/>
            <dbReference type="ChEBI" id="CHEBI:18234"/>
            <dbReference type="EC" id="2.3.1.122"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mycobacterial A85 antigen family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="4"/>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000945">
        <property type="protein sequence ID" value="MST34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029649072" description="Acyl-CoA:diacylglycerol acyltransferase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="30498" checksum="03A6EB1D26B1ABEE" modified="2021-04-07" version="1">MTVSRRRFLVGGAATLAAAGAAFGALDAVDGTLVQHGLHKLGVARSPDLVLPRPPLTELNGSFDSRYLKRSVGWRITRPPGSAPLDGVLVCLHGYGGNHLWAFDVVHVPAAAAHVGLRVAVAGVDGGHDSYWHRRADGTDALAMLLDEFVPLVRRRVGHHRQALMGWSMGGYGALLAAERSRPEWVAVAPASPALWLAAADTAPGAFDSPADFAANDVFTGEQTLAGLGIAVACGTEDPFYAATRALVARMDFPHHTWFTYGFHDAPFWRAAAPVQLRDIAPSFRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU0</accession>
    <name>A0A7K0JWU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000820">
        <property type="protein sequence ID" value="MST34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="106"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="439" mass="46706" checksum="4DF0FF0CE431D292" modified="2021-04-07" version="1">MDSTSGAPAFAKGFERIRVLWPDHLGLARGKYVPAGMAARGARHCTGTWALGFDRQMTPGTPGSFFFEGLPDMDARFSPGTVRPGWEGPGTGVVVADLEREGQPVAVSPRGALRRAIADWEALGYRPEVGIELEAYLMEPDGAGGWQPISTPGAFVYGTGPSVDPHGIVGELWDAADRAGIAIEAINSEYDESQFEFTLAHTDALEAADRTFLFKQMARELATRHGLLWTFLGKPVNDRGGSGLHVNVSFTAPDGGNAVDDPSDPDGLSPLARRAAAGLLAHHQGLCGLVAPTVTAYRRLRPGQLAGYWANWGHDHRGATVRIPPERGAAARLEHRLADGAAPAHVAVAAVLQAARLGVVDELELGPPETGDGFEHVDATVGCPTNLGAALDALEADGALCDAVGKELVQQHLAVKRTEWDAFCAYTTDWEKRAYLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU2</accession>
    <name>A0A7K0JWU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000990">
        <property type="protein sequence ID" value="MST34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="16008" checksum="DCFA57C9E599072F" modified="2021-04-07" version="1" fragment="single">MRQDLSGRSLELRAGRVPFVHARVTLAEAPTSAKPGDEAIIRADGAIEGFVGGVCAESTVREVATDLLASGAGPIVLRVTPEPEPDQPGRRVVHNACLSGGTIEIFLEPAVPPPLVVVVGRTPIARALATLGAGLRWAVQEWDGELPPDAVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW8</accession>
    <name>A0A7K0JWW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000972">
        <property type="protein sequence ID" value="MST34372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="215" mass="21591" checksum="B9DDFDBBCAA9AB16" modified="2021-04-07" version="1">SLGEYSALVAAGALEHEEAARLVAERGEAMQAAAEAAPGTMAAVLGLEPELVAAACKDVDGVWVANDNAPGQVVVAGTAAGIEAASARAKDLGAKRVLPLPVGGAFHSPLMGGAQERLEQALAGAAFGAATTPVVANVDAAPHLDGFPALLGAQLAAPVRWRESLLTMRSLGAGIFMELGPGAELSGMVKRTVDGAERVTVNTPDDLEAARARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX01</accession>
    <name>A0A7K0JX01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001026">
        <property type="protein sequence ID" value="MST34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7438" checksum="790182507ECEAE2A" modified="2021-04-07" version="1">MAGEFADIRRRLEAISEELADLAMERLRESIDNGGVELPVDERRLTRARRAVEKAAGILAEPDDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX38</accession>
    <name>A0A7K0JX38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001047">
        <property type="protein sequence ID" value="MST34513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="68"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="257"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="592" mass="60778" checksum="B7851D867416869C" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX68</accession>
    <name>A0A7K0JX68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgC</name>
        <name evidence="12" type="ORF">GHK86_17310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01001023">
        <property type="protein sequence ID" value="MST34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="43966" checksum="2F389DF801F8E7D5" modified="2021-04-07" version="1">MPRVLAIVLAGGEGKRLMPLTLDRAKPAVPFAGQYRLIDFALSNLANGGFLKIVVLTQYKSHSLDLHVTRTWRMSNLLGNYVTPVPAQMRRGRQWFSGSADAVFQNLNLIGDERPEHVCVFGADHIYRMDPRQMLDQHVATGAGVTVAGIRVPRQEASKFGVIGAGEGTRISRFDEKPADAPGLADAPDEVFASMGNYIFTTQALIEALHVDAATDSSRHDMGGDIVPAMVASGDAHVYDFSHNQVPGSTERDRGYWRDVGTLDSYYEASMDLVSIHPVFNLYNTDWPIYTAGTTQPPAKFVFEDHERRGQAFDSLVSNGVIVAGGTVRKSVLSPGVRVEPGALVEEAVLMDGVTVHAGAVVRRAIVDKNVEVAPGAGLGVDPAADRTRFTVSDAGVVVVGKGEKVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX85</accession>
    <name>A0A7K0JX85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000879">
        <property type="protein sequence ID" value="MST34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029851260" evidence="1">
        <location>
            <begin position="28"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="37096" checksum="E21CB704FEF4313B" modified="2021-04-07" version="1">MGGALVVGSGALWTPPLVTAVATPAAASSSGTANGGSAPKTPTLVATELGYPLGLSMGPGGQVYVADFGSVDGTAPGRILRVDPVNGTADVLFSSTAYWPSDVSFDAAGNLYFTDYGWDGDDGGDQAHEGGRVVVIAAGDLGSDTPVSADLATGLDDPSYLLVDPDGTVYVSDTGEADGRGDADPSGRVLGYPLRANPPPIAVGTPALVAGTGAAITGGAPLPVQPVPAGTPVSEVAVFVAFGLAGAGSVLYVADEYAHVVYAVDLPSATIKTYAGNGRATSLAGTGDGASAIDAEVPFPQGLAVDGAGNLYILQIEGQVRRVDPHGTITTVSSGAYVSDNVGITFDPRTDSLFYISNDYPRPGQLHRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX87</accession>
    <name>A0A7K0JX87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CocE/NonD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001036">
        <property type="protein sequence ID" value="MST34492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="328"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="595" mass="65280" checksum="57478107043537FB" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE8</accession>
    <name>A0A7K0JXE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001112">
        <property type="protein sequence ID" value="MST34627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="27404" checksum="1ECF4A36A70551F5" modified="2021-04-07" version="1" fragment="single">DRQADADEQRRPDELRQPQPPGVRRFGGFRRRGHRTLPTGSRAAAPSRYPLGYDVAVEEVVAVTVHPSPPARQEGHWAPGSVLAVCAHPDDESFGLGGILDAWARRGIPVALLSFTRGEASTLGADEGALATVRAEELERAAAVLGVGRTTLMDYPDGRLSVQDPRALAAAVEALAVEVRADTLLAFDAGGITGHPDHQRATEAALLAGERLGLPVVAWCLPETVATTLVAEFGVPFVGRPDIEIDLRVAVDRARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP6</accession>
    <name>A0A7K0JXP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001133">
        <property type="protein sequence ID" value="MST34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="13927" checksum="64468B5C58211D4A" modified="2021-04-07" version="1" fragment="single">MLAAQLTAFGWPPAVEVREVPEPAPGPGEVVVAVEAAAINRRDLWVARYDGYCELPVTLGSDGAGRIAAVGDGVEGLAPGDEVVIDPTLGWGAGEDRPGPDFDILGAPTPGTLAELVAVPAANVHPRPGRLSWGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW7</accession>
    <name>A0A7K0JXW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001227">
        <property type="protein sequence ID" value="MST34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="46"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="204" mass="19572" checksum="9083E5556D28423C" modified="2021-04-07" version="1" fragment="single">RTPALPRVAGPAEAVGESPRGGLVAPGAGDNAAAALGVGAAAGDVVVSIGTSGVVAAVSAAPTADPSGMVAGFADASGAFLPLACTLNGVGVLQAACRLLGVSASRLAELALSAPPGAEGMVLVPYLVGERTPNRPDATGALHGLTDTNLVAANVARAAVEGLLCGLADGLDQLRRRGVDARRAILVGGGARNPAVVALAPAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY0</accession>
    <name>A0A7K0JXY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001240">
        <property type="protein sequence ID" value="MST34825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="17677" checksum="CEB190CF1352944C" modified="2021-04-07" version="1">MDVALQDQAEVARDFLSGLLARFGVDAQLGVTTSEEDERVELRVDGGNLGLLIGPKGATLLAIQDLTRTYVQHRTSARNGRIHVDVAGYREKRAVALAAFVRKVAEDVTNSGKAVALEPMSAPDRKIVHDTAAQIGGLVTRSEGEDERRHVVLLPAPDGAGSPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY03</accession>
    <name>A0A7K0JY03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000984">
        <property type="protein sequence ID" value="MST34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="18028" checksum="84560F3D71BDE32D" modified="2021-04-07" version="1">VLTPTGGVLSVPPAHRAAVSAALDGRGADGVSEVDGPLAAALGRPGAPILHGVFRWSSAPAPFPDLGVWIPADDPSVPDWLHPFGGEVLVALDAGRYVAGVGIKRHDPTGGELAVVTEPEAQGRGLARRLVSQAARRVLAGGAVATYLHAPSNLASARVAEAAGFPDRGWQVLSLGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY84</accession>
    <name>A0A7K0JY84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001303">
        <property type="protein sequence ID" value="MST34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="211" mass="22549" checksum="C2B22AB187A12A40" modified="2021-04-07" version="1" fragment="single">GDGATAGAGDRFGPGELIEAVLDRTGYLAELQAEGTVESAGRIENLEELVGAARDATGLDAFLEEVSLVADADEVDADGSQVLLMTLHTAKGLEFPVVFLIGLEDGVFPHLRSLGEPDELEEERRLAYVGITRARERLYLSHAWCRSLWGQTQYNPPSRFLKEIPEELVRQAGGGHRSVRSGGRSWASGGSSGPGGSRGFAPNREDVVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC2</accession>
    <name>A0A7K0JYC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001275">
        <property type="protein sequence ID" value="MST34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="16922" checksum="B1F4C7235F1E3BA6" modified="2021-04-07" version="1">DLIVTAGNDGQFRRLVDVLGVPELADDPRFAHNEDRTANRDELRPLLVERLATRTKLEWFREIIAAGVPCGPINTIDQGVAFAEEVGLDPVVEVGDGDRRTPTLRHPLRFSDSEPRYRLPPPRLGEHGAEIRRWLAEPWPPRPADDPAGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL7</accession>
    <name>A0A7K0JYL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001380">
        <property type="protein sequence ID" value="MST35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="335"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="633" mass="66004" checksum="F3EC7B4AE73EE727" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL8</accession>
    <name>A0A7K0JYL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">atpF</name>
        <name evidence="16" type="ORF">GHK86_18135</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001118">
        <property type="protein sequence ID" value="MST34634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST34634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="19819" checksum="EEED32362BBD961F" modified="2021-04-07" version="1">MLLAATKNFLVPNLTFVFELVAFLIVLAILWRYVLPPLQKALDDRQANIRQGILDSEEAKRRLAQTEADYQQAMDEARVKAREMADEARRIGEQLRDEARRRGEQEAERIVAAARSEIEASVRRATEDLRRDVTGLVVAVVEKVVGEGLDAEAHRGLIDRTISEIEAEAAAPTSASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP7</accession>
    <name>A0A7K0JYP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001418">
        <property type="protein sequence ID" value="MST35085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="13388" checksum="E0EFFC75DB63294C" modified="2021-04-07" version="1" fragment="single">MAVIDVAGYVAELKDHAIDHGFHVHDERHFVETYSLRQSWEVELHPEEGCNGPLDLHLALEVDPRVLLAFEDKVMELPEEAEPPDEYSFPLTFTWALPPLAHSPDLLPLALDLAGIGGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT1</accession>
    <name>A0A7K0JYT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-oxidase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001163">
        <property type="protein sequence ID" value="MST34704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-oxidase_C" evidence="1">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="14357" checksum="DCBD477D508999B2" modified="2021-04-07" version="1" fragment="single">TESGRHFDGLDACGLIVVDEGGPALVEATLAVVDDECRAGGAEPLDEDFAARWLEHRNEVPSLGDLAAAGIVADTVEIAASWAALPGIYTAALAAVGSLDGTLAVSAHQSHAYPDGACLYFTFAGRPEGAAAGPAAGAAGPAGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU0</accession>
    <name>A0A7K0JYU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Squalene synthase HpnD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001450">
        <property type="protein sequence ID" value="MST35125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20557" checksum="2FC1C91BC9544F66" modified="2021-04-07" version="1">RRYPIPMGALHELVDGCGMDVEGAHYADFDELVAYCRAVAGTVGRLSLGIYGATDPVRAEALADALGVALQLTNVLRDIIEDRDAMGRVYLPAEDLARFGCGPDVTGDPDALRALVSFEAARAADWYDRGLALLPMLDRRSRACTAAMAGIYRRLLTRIQADPDAVLRGRVSLPTREKALVAARALTRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ76</accession>
    <name>A0A7K0JZ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001556">
        <property type="protein sequence ID" value="MST35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="257"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="50524" checksum="8CDA7CDCFED806FB" modified="2021-04-07" version="1" fragment="single">MAERLADLARRKEAARHAGAPHAVERQHAKGKMTARERLDYLLDPGSFQELDMLARTRAPGLPDEKRPYTDGVITGFGTIEGRKVCVFSQDFTVNGGSLGEVFGEKVHKVMDLAVSLGVPMIGINDGGGARVQEGVVGLHYFGGIFKRNVDASGVIPQISVIMGSCAGGAVYSPAMTDFIFMVRDTSQMFITGPDVVKTVTGEEVTLEELGGAVTHATKSGVAAFVAADEKSCLDEVRYLLGFLPSNNLEEPPRVLTGDDPARATPELGELIPASPNQPYDMTKVITTVLDDGDFVEYHGRWAMNLVCGFGRIDGHVVGVVGNQPQVLAGVLDIDSSEKGARFVRTCDSFNIPLVTFVDVPGFMPGTDQEYGGIIRHGAKLLYAYCESTVPRIQVITRKAYGGAYVVMNSKGIGADLAYAWPSAELAVMGPQGAVDIVYRRELAESPDPVARRAQLVDEYTERFANPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ80</accession>
    <name>A0A7K0JZ80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001273">
        <property type="protein sequence ID" value="MST34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="20492" checksum="8C5F1853D62A2719" modified="2021-04-07" version="1" fragment="single">MHEKLRNEVNALFRAQAGVVSRAQLRGIGLTADAITHLVRADHWEAVGRLVVRATAAPTGPEQDLWAAYLAAGPGAAVSHASAAWLWDLLPAPDHPSVSVPRHAGHRVPGVELHRPRQPLDHLRVRRGLVCTDPVRTLCDLAGQRAPDEVDGVVDRALASGLVTVTGIAAVLARAGAPGRNGPARLRAALDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ94</accession>
    <name>A0A7K0JZ94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001557">
        <property type="protein sequence ID" value="MST35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="22901" checksum="0A20BA26727EA23D" modified="2021-04-07" version="1" fragment="single">FCLGKNYRAHAEEFARFSGEAQAVPPAPVVFTKAVDALCGPSDLLAVPADLAGGLDYEAELAVVIGRAGQAVPPDEALGYVAGYSVLNDTTARDLQRTHAQWYLGKSLPGATPWGPCIVTPDELEPFAERRIGAEVNGDRRQDAVLGQMIFTVADAIASISRVVALLPGDVIAMGTPSGVGVGYDPPRFLGDGDEVRCWIEGIGELRNRVAVRQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA3</accession>
    <name>A0A7K0JZA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_21070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001520">
        <property type="protein sequence ID" value="MST35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="19652" checksum="048C4B0CDBABFC45" modified="2021-04-07" version="1" fragment="single">MTLLPQSLQARMAARRRRGSSDDPRATEQPNVPSRLADFPPHFWALVVLTGAGAGLGAIGFMALLHAVQHAAFGYHRGEYSVAAAHRSHLRRVVVLAVGGLVTGAALFGLRRVAGGTGGEPTRAVWMHTGDVQPLPTFASGAISEVSVGMGASIGREAAPQHAGAAVGAWLARRAGLTPEQRRVLIACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH4</accession>
    <name>A0A7K0JZH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001334">
        <property type="protein sequence ID" value="MST34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="213" mass="22774" checksum="CBFEE8E5063C8E79" modified="2021-04-07" version="1">AERLSARGGRDALFVQADVADVDQAQASVAATVEGFGRVDCLVNAAGLTTRGSLLDTTPELFDAHVAVNLRAPFFLMQAAVRDMRRRQSPGTVVNIITMSSHGGQPYLAPYAATKAGLVGLTKNAAHAHRWDRIRINGLNIGWTETEGEDAIQRQFHGAEDGWIEAAAKTLPMGKLGQVDEIADMVVFLLSDRSGVATGSVIDWDQTVPGAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH7</accession>
    <name>A0A7K0JZH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001606">
        <property type="protein sequence ID" value="MST35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="26468" checksum="2D5D19ED24CCBD7B" modified="2021-04-07" version="1">SGAVWVRRGRGRRRGGAAGTRPGFAASAADLCRWFAALAVGGRGRLLPDTAKREMQRVHWRVERPGSDGDEDYGLGLELQRLGERRLFGHGGGFPGQITKTLVDPGAGLVVTALTNASDGPASDIARGVYHVLDHLGEGAAPARALRRLEGRYVNLWSVNDVVAVDGALGVGNPDSWKPFADGARLEPVDATAACITRDSSFGSEGEPVRFELRDGAVDTVRWAGATLWPEARWPAAERRLLRAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZJ2</accession>
    <name>A0A7K0JZJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001601">
        <property type="protein sequence ID" value="MST35302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="91" mass="9396" checksum="C5CE070761C06108" modified="2021-04-07" version="1" fragment="single">MDSTAATSASGSRPVTYQFQLPAEDPARQTVLGFVVASRAAACTPSWGDYYSLGQAATTLALDARIAQVREDGGTPIVSFGGERNTGLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV0</accession>
    <name>A0A7K0JMV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="23039" checksum="F3ECAE1D589F62C5" modified="2021-04-07" version="1">MTGELVQWVQAGLSDAPAWGSTAFAALTYRWARNRNRWLGLLEGAGVTPAQLESVLRERPKTAELFFSIMRIAEETAQEERQRALAALVVAGVQSDSDQVDELLVLRRAVERLDDPHFRLLLLVEAHPTTPLSPEGGSAGVSDAYLLELWPAADKMIVPLRLALEREGLIRNVLQPGRWAPSGGGGDAWLLTEFGESLLGYYRALGGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN37</accession>
    <name>A0A7K0JN37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000051">
        <property type="protein sequence ID" value="MST31376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="8162" checksum="F1539F7C2786F78F" modified="2021-04-07" version="1" fragment="single">MTPTTRCDAILRLIDETLDAGAPTGPDALAAEVRQWVQRTYPGEEHLADAAVASARRAYADGASVAESCERAREFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN56</accession>
    <name>A0A7K0JN56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmA</name>
        <name evidence="6" type="ORF">GHK86_01385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000055">
        <property type="protein sequence ID" value="MST31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="8941" checksum="D6A5C7BE759E6D38" modified="2021-04-07" version="1">MSKTKGGGSTRNGRDSAAQRLGVKVFDGTAVTAGSIIVRQRGTHFHPGENVGRGGDDTLFALTDGKVKFGARKGRRLVDVLTEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN95</accession>
    <name>A0A7K0JN95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000058">
        <property type="protein sequence ID" value="MST31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="158"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="354" mass="40300" checksum="E3F9643A9EF2CA01" modified="2021-04-07" version="1">MPATEELSWTLVGSDGMPVPAAESFLAFLAARRFSPNTVRTYAFALGAYFSFLEERGSDWQAVRLEDLATFVAWLRRPAPNVIPLTGTAARRSARTVNKILAGVSSFYEYQVRNGCEVAGHLSVWRDVGAKRYKPFLHHVDRSAAQRRSTLKVREDRHHPRTLTAAEVEALLDACERLRDRFLMALLYETGMRIGQALGLRHEDMRTWAREILIVPRDDNANGARAKTRQTHVVHISTELARLYSDYMHAEYGDLESDYVFVNLWGGERGRPLTYGAVDHLVRRLRVVTGFHFSVHQLRHTHATELLRSGVPLVVASRRLTHTSVATTSDVYAHLDADDLRRALEPYWARRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNA9</accession>
    <name>A0A7K0JNA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muconolactone delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026029">
        <property type="entry name" value="MLI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02426">
        <property type="entry name" value="MIase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="11263" checksum="5096CC13C7F24D02" modified="2021-04-07" version="1">MTAEWLVEIDIDWPPGRGEQLRRELAEAEGRRARELASAGLLVRLWRVPGRWANVGLWRAEDATELHAALCSLPLHPWMQVTVTALAVHPSDPQSPQPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNB0</accession>
    <name>A0A7K0JNB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-keto-5-aminohexanoate cleavage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000040">
        <property type="protein sequence ID" value="MST31341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="300" mass="31935" checksum="97167971C2DA84F9" modified="2021-04-07" version="1">MGVHSVNWEPFLTCAVTGAGDTLSKHPDLPVTPEQIATAAIEAAEAGAAIVHIHVREPATGKGCREVAYYREVVERIRDSGVEVLINLTTGMGGDVVVGDRGGEDTPAPGSDFVGAMERLVHVEQLRPDLCSLDCGSLNFDDDRLVYVMPPAYLRPSAARIRELGVKPEMEVFDLGHVAFASRLVAEGLVEPPALFQLCLGISYGAPSTPAAMVAMRDHLPEGAVWSAFGLGRMEMPMVAQAMLLGGNLRVGLEDNLWLRRGVLASNADLVRRAKAIVEDLGGRLASPKEAADRLGLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JND7</accession>
    <name>A0A7K0JND7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000072">
        <property type="protein sequence ID" value="MST31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="131" mass="13767" checksum="FC761658926A3A19" modified="2021-04-07" version="1" fragment="single">MSPERVVVVGGGVLGTFHAWEAVRRGFEVVHVEREAGARGATVRNFGLIWVSGRAPGAELTLALRARDAWEVAAEHVPDAGFRPAGSLTVATEEDGPEARAALELAASLPDAADRGFALLEGADARRRCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF3</accession>
    <name>A0A7K0JNF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000084">
        <property type="protein sequence ID" value="MST31500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="5">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="406" mass="43015" checksum="1102B38E393E0797" modified="2021-04-07" version="1">MPAVVETAELGGPTARTPGRGAELALSERDVIEALRPVTDPELGLSIVELEMVKAVDIRRGGTVAVTVALTVPGCPLREEITRRVTEAVRPLDGVRDVVVDLTVMTPEELSTVRQRVQGQAGGHAHGGQGHAPLGHESGRTSAFAQPGSRTRVIGITSGKGGVGKSSVTVNLAVSLVRAGYEVGLLDADVYGFSIPGMLGIDAAPTVRDEKMIPPVAYGVRTMSIGYFVEEDQPVMWRGPMLHKALEQFLVDVDWGEPDFLLIDMPPGTGDVALSMAQYLPTSEVYVVTTPQAAAKRVAQRTAYMARKINLPLRGVVENMSWFTGVDGTRYELFGRGGGQELAEELGVPLLGQVPLVPGLREGGDTGRPVTVGDPEGEAARAFAAVAGEIAARGRSRIFRPELTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNI3</accession>
    <name>A0A7K0JNI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="270"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="509" mass="54074" checksum="04BA7C9E2018FA00" modified="2021-04-07" version="1">MATISPPAELLLEVESLSKTFPGQVALDRASLHVRRGEVHALLGLNGSGKSTMIKVLSGYHREDEGSVVRLFGTAVPAHQVRPSHPRRVAVLHQDLGLLPGMSVAENMGIGTAFRRSATGRIRWREQRSEAAAACRRLGLEVDPSLPVGALDASAQVLVGLARAIASLERIEGSLVFADEPTAALAHRDVDRVFAGFRELATAGASVVVVTHRLEEVISYCDALTVLRDGRTVAEGRTAGLERAELASLLTGSTDGADLGSEGQARPIVLDGPPALRVHRLRGRVVESLSFEVPAGEVLGIAGLVGSGREELGPLLVGAVPRVAGEVCVVGTVLGPTPRAATRAGVGFVPADRKRHGILATMSVGQNMTVNKEIARLGGAWLDSGLARAEVDQWIDRVRLDPPDRRRRISLLSGGNQQKVVLARWLRRSPRILVLDDPMQGVDVAAKRAIYRIVRAAAAEGSAIVLISSDATELAEAADRVLVLRDGRVGAELTGQERTSERIVMEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM0</accession>
    <name>A0A7K0JNM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000095">
        <property type="protein sequence ID" value="MST31548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9211" checksum="7020CEEC9C24C6D8" modified="2021-04-07" version="1">MAPDALRRLGGDPVGLAREALRLASGAAFAGLALRRVTLYHAVGNIGSCGVATGAGYRLEGVLRASHRYPGGSDHDEHVHGRLAADAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR6</accession>
    <name>A0A7K0JNR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1778 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000103">
        <property type="protein sequence ID" value="MST31598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014795">
        <property type="entry name" value="Vibrio_phage_ICP1_Orf50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35401">
        <property type="entry name" value="PTHR35401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08681">
        <property type="entry name" value="DUF1778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="12357" checksum="5EB9B2058000FF14" modified="2021-04-07" version="1">MRKVRRALEPMVHPQVPVITPSIQARKRHRLEVRVTPAQDALIRRAADLEHTTVTSFVLDTVTAHATTVIEAHRDLVLSGDAFDRFLAELDKPAVAVPELFRRHPSLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT9</accession>
    <name>A0A7K0JNT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_02145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="369" mass="38343" checksum="F692C9B48FC2EACC" modified="2021-04-07" version="1" fragment="single">MTTSEVRVEAAGPARRRRSGGGAARRLHSLRPSNISLVYMYAAGFILFTAWVPHLWLSGTTQKTILNISFAVPAMLAVGLMVPLLAGVFDLSISGTMDLSSVVLASLMIYSHFPAWVAILVVLGISVVVGAVNGFLVAVVGIDSFITTLASSAILEALAVSFSGNIQVTGFKAAFANFGSGNLVGGIQYQVLYVAVIAVVVWYVVEHTAAGRYLQATGENEDAARLSGVPTKRYIFTSLIVSAVIAAFAGCVETAVIGGGESNVGDPYLLTAFAAAFLGATQFKQRFNVLGTVAGVWVLASGVEGVTVALKSYAWLNQLFFGSALIVAVGIGRVIELNNGRIAVRRRRASADDGEAVASLVGAGPAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW9</accession>
    <name>A0A7K0JNW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_02425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="15876" checksum="D054FC8E2461AD74" modified="2021-04-07" version="1">MGMRPGELAGLLWTDLDLDGQPPTLSVSGSMKYADGGKVVGRGDVKRSAAGRRTIALPPHAVKALHEQRRRQDAERDAAGGDLRTAMHRLGHTTPAMTLAVYAGVAEDQDRAAADAVNDCLGPRRQHNAWQPPAARRQQAAPSADRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP00</accession>
    <name>A0A7K0JP00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000103">
        <property type="protein sequence ID" value="MST31601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="32619" checksum="F1FFC610DD857E96" modified="2021-04-07" version="1">MPSTNQAPTIPTPTPTPAPGRARSRQRRRALTAPVVGLGAFMLAGSALAAAGPSAFAASRAPTHGRTTCAVAGDECTSAVAYANAHDGGGARVLAVEADTEAHGGAVQHRVFDIRMATNDGVYNLHVYRNDRAPYNDGVWWQKPAENQHPSGGSGGEPGSGGGEPGGGSVTGGDAPAISAGQAAADATAFVTGQGRQVLSVKHDHLKSQGQKDYYQVKLQLGDNGRNAGTTNVWVDATSAPGTVTAASGSGLDYRDPSLVAASTAWANAVAAVGGGTVYKTNLNGGKWRWYWVFVRDGATKYKVGVDAVTGVVTQVRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP10</accession>
    <name>A0A7K0JP10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000121">
        <property type="protein sequence ID" value="MST31710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="492" mass="54440" checksum="6F7AFC189485C760" modified="2021-04-07" version="1">MTDEPDETEQAKADRAAQPERPEPTDDLVETHHSLATPAGELRYTATAGRVVLREEHLEDGTFGGYRPKAEMFVTSYTLDGADPATRPVTFAFNGGPGSASVWLHLGLLGPRRVVMGDAGNLLPPPWGLADNPETLLAHSDLVFIDPVTTGYSRVVEGGKAAEYHGFQRDLESVGALIRLWTSRHGRWLSPKFLAGESYGTIRASALADHLQSRYGLFPNGIMLISSVIDMATIRFTEGNDQPTALYLPTYAALAHYHGLHGDRSLEEVRAEAETLAERDYPWALARGGRLGADERADLVRRVAAVTGLSEGYVSRAGLRIEHQRFFRELLRDRGQVIGRLDGRFVGWEADDAGEKPSADPSNVAIHGPYAAAFNHYVRQELGYGNDLPYEILTSRVQPWSYAEFEGRAVSISSMLGQAMRHNPHLRVHVACGYYDGATPYFAAEHAFAHLEIPEQLRTNIEMRYYEAGHMMYVHEPSRLRQSADLAAFVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP21</accession>
    <name>A0A7K0JP21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000111">
        <property type="protein sequence ID" value="MST31663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20594" checksum="0FD1F327B19A2667" modified="2021-04-07" version="1">MVLVGEGVRAAAEALVGRRLDEVRYSTMKWGRKDRRFWDHEVAHVVEYGVDLVTDWGTTGVVWTSYGAFGMGVDLVEGPVLAEFARAGLDVSPRQARTVDVTHLVPWRGLIGRKIQSVTVHLHEARWDEPVTGPAAVTVRCDDGPPVAAVCGSWIGPADPIYLTGDDIIILWEPEVATAVAPSLELGLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP95</accession>
    <name>A0A7K0JP95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000134">
        <property type="protein sequence ID" value="MST31786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="6659" checksum="28C9A5786F40D9FA" modified="2021-04-07" version="1" fragment="single">MSGEFAAIDRLRRRLPAPGPGEVWIGDDTAVLRAPPAGARLLLAADAVVEGVHADLSLLGLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA3</accession>
    <name>A0A7K0JPA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000131">
        <property type="protein sequence ID" value="MST31775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="34762" checksum="87970558D4CA1AE5" modified="2021-04-07" version="1">MPRVVAATDKFRGTATAAEVALAVAHAAATAGWVCDQVPVSDGGEGFADVLGGRARLVMVRDPLGRPTQAEWRMLDDGRTAVVEMALASGLELVGGPEGNDPVRADTAGTGELIAAAVQAGARRVLVGVGGSASTDGGLGALDVLEPHSRLRGVELVVACDALIPFVDAARVFAPQKGASPAEVELLARRLERLVQVYRERFGVDVSALTGGGAAGGLAGGLAAIGATLVPGFAVVADAVDLADRIEGADLVVTGEGTLDEQSFGGKAVGGVVELAAELGVPALVVAGDAVGPWGDPAQRAAAVAGRPGLAVEVLVERFGTARAFADPCGCVQEVVAARIGRGMAAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ7</accession>
    <name>A0A7K0JPJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000075">
        <property type="protein sequence ID" value="MST31479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S53" evidence="1">
        <location>
            <begin position="56"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="432" mass="44103" checksum="39F75BF939F69613" modified="2021-04-07" version="1">MAFAALGAVGGTASAATGNSTPITYTVHPIAIQAASSLSSGGFVPSTCVKEVGLACYTPSIFHTAYQIPWTVNGEPAGTGTSVAIIDAYGSPTVAQDLATYDQTFGLPAANLHVYYPGGKPTYNPLQNHSETSWAEETSLDVQTVHALAPGATINLIVAANNAGNVLNNAEQYAITNHLGDVMSMSFGSPEAAIAGGGNNLQLQQADAIYQQAAKDGISVFASSGDSGASAGYPTANASFPASDPYVTSTGGTDLFANNKGVYQSEYTWNDSDPSTCPFGCQYGVFGATGGAPSSVFARPAYQSATGYATRTTSDVAFNASVYTATMIYLGFLGGPNNGFYFFGGTSEASPSWAAITADLDQAAGRDLGQMNPILYSLPTADFHDITVGNNALDGPGFSAGPGYDLPTGLGTPIVSKLMGSLAKGARLGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP9</accession>
    <name>A0A7K0JPP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase_M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_03960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000162">
        <property type="protein sequence ID" value="MST31881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="71"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="453" mass="48328" checksum="4836AD029E8E33AE" modified="2021-04-07" version="1">MTTDNPITPRPPVPGDPFGLVRHHGEEPPPEQPLNGRSNRLALLRLLVVVAAVLGAAYAAGVGETVVLVGFLVLCIVLHELGHFLTAKAARMKVTEFFVGFGPRLWSVRRGETEYGVKALPLGGYCRIIGMTNLEEVDPADEPRTYRQRPVWRRLTVAVAGSCMHFLIAFGVLFAMFAATGDVSGYLPVPGNSPIIAIEGLAHGPSPAQQAGFHLGDRIEAVNGRHFATFSAMRTYIAARPDTRLAVEVDRHGHLLTLHPRTVNLQQVAVTGVGAAATKVSHPTGFIGFEVSSVVHSSLGASVVHAAGDWWHISSVTLGAFGRLLTLHGIQSYAHLLASPSAAAHPGPHSVRFESPVGIVVLLHQAAGAGLAWVLYLLAAINLSLGIFNLVPLLPLDGGHVVIALYEGVRGAIRRRPYHADVAKLLPVFYLAIALIAFLGISALFLDIRQLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR6</accession>
    <name>A0A7K0JPR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000184">
        <property type="protein sequence ID" value="MST31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="113"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="233"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="477" mass="50812" checksum="214E24EBB887D996" modified="2021-04-07" version="1">MEYAVAGVEGALAAGARYADARVMEVRSEAMSAQNGDIQALRQRERAGVGVRALIGSSWGFFATTELGEAAARQAGMRAAETARASARVPGPDLELAAVPAVTDHWESPCEEDPLAVSLSEKADLLVGITRVGLEAGAQLALADYQIWDTRKWFASSEGARISQRIRECGGEMSVTAVGDGETQRRSYPGIRGQYGTSGWELMRRLDFPGNAARVGEEAVALLSAPPCPTTTTDLVLGSEQMALQIHESVGHATELDRILGWEAAFAGTSWLDLSQLGSLRFGSDLMQITADATIPGALGSFGYDDEGTPAHRVDIVKDGIWVGVLSGRDSAALAGIPAGGMVRADGHDRIPMVRMTNIGLLPGPHSLEEMIAETADGIYMDTNRSWSIDDRRLNFQFGCEVAWEIKDGRLGRMLRNPTYTGISPAFWGSMDMVGGAAELTNWGTPNCGKGQPAQIGHTGHPAVPCRFRGVRVGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ54</accession>
    <name>A0A7K0JQ54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="11">BCAT</shortName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ilvE</name>
        <name evidence="12" type="ORF">GHK86_04980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 11">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="WJHE01000208">
        <property type="protein sequence ID" value="MST32080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="34037" checksum="E1BFBF5A5B3EAF1F" modified="2021-04-07" version="1">MPITPTEKIWMDGELVDWDDARIHVLTHSLHYGCGVFEGIRAYPTADGPAVFRLREHIQRLLRSARIFLMDVPFSEDELVTATKQTVAVNGLEQCYIRPLVYLGYGEMGLNPLPAPVQVSIAVWPWGTYLGDEGLTRGVRMKISSWQRHGPNAMPPAAKGTGMYINSSMAKVEALKAGYDEAILLSPQGYVSECTGENLFVVRRGRIITPPVSAGALEGITQDTVATLARDLGYEVVTDHILRSDLYVAEEAFLTGTAAEVVPIRSVDDRDLGDGRPGPITRRLQELYAQAVRGQLDQYKDWNEHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF6</accession>
    <name>A0A7K0JQF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000235">
        <property type="protein sequence ID" value="MST32185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14013" checksum="E55159B617FF5432" modified="2021-04-07" version="1">AAVGRQVYTGLARLAQYKSAGRLSTIQALVVDLGSNGVFTPADMTELEQLAAGVPRVVLVNVRVPDPWGPESNQTISSVAHRPGFAVVDWWKASENRALLYPDGVHPDPQGAAVYAHLVDAALHLPAHRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI5</accession>
    <name>A0A7K0JQI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000245">
        <property type="protein sequence ID" value="MST32206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="174" mass="19212" checksum="76891D6736C57798" modified="2021-04-07" version="1" fragment="single">MVFADIYLQPDAPDPVLDEQTIVAAARRHVPDAGRLLAVDESGGEARAYFLEGDLVVKTQRPHRLRPRTSLAKEAFFLNELHRCGDFPVPHVLGQGELRGTEYLCLTRIAGAALSRTNLDPGGRRRALTELGRTLRAIHDIDQAALDHSELMPGDREPADLRARIADTFARLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP1</accession>
    <name>A0A7K0JQP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_05960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="11"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="449" mass="48064" checksum="BCCDBDD7389AB351" modified="2021-04-07" version="1">MRSAYDAGLTRPLPWRRAQLRGLDRLLVEGERELLAALRSDFGKPDLEAWLTELAHVRHELAHIQSHLAAWARPERVPLRAVLRPGSATTVAEPLGVALVLAPWNYPVHLLLLPMAYAIGAGNAVVGKPSELAPATSAALARLLPRYLDERTTALVEGDATVATALLEERWDHVFYTGNGRIGRVVMAAAARHLTPVTLELGGKSPAIVERSADLAVAARRIAWGKFVNAGQTCVAPDYVLVDEPVAEALLAELGNAVRSLYGDDPAASPDLARIVDDRHVERLAGLLAGVGPDRLVTGGRVDRATRYVAPTVVRSAGGDDPLMHDELFGPILPVITVRDVDAAIAAVRARDKPLALYVFTEDTGVAERVVTETSSGGVCVNGTLVHLAVTDLPFGGVGASGIGAYHGRAGFETFSHRKGVLVRRSHPDPGLMYPPYGRAARWVLRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP2</accession>
    <name>A0A7K0JQP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000258">
        <property type="protein sequence ID" value="MST32256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="13297" checksum="A32C8895F73C4D3D" modified="2021-04-07" version="1" fragment="single">MSSTDHAPTNGHVPADRPRRRSGSDVTREGLRNLRPDRDALVGVNAGAPRRERRRRDPQSMVPDATFASYYGRPVLNPPTWAPLDIAGYLFLGGLAGSSSALAAVASLRGRRRLAAPLELGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR8</accession>
    <name>A0A7K0JQR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_06120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000265">
        <property type="protein sequence ID" value="MST32298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="243" mass="26294" checksum="54A07523FFA7557E" modified="2021-04-07" version="1">MTSYPTYLRYELLRTVRNWRFLLFSLLFPLVLLLAVGGSNRHVHLDGISFPLYYMTGMAAWGSMSAVVASGARIAAERQAGWTRQIRITPLRTRSYFQAKVVAGYLMAVLSLAVLYLAGAALGVRLPAGGWLLMTALILVGLVPFAVMGIALGHVLRPETLGPALGGITSLFALLGGAWGPLLHTGVLLTIAKALPSYWLVQAGKAGLDHRGWALEGWVVLAVWSVVLARLAVLAYRRDTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU9</accession>
    <name>A0A7K0JQU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000270">
        <property type="protein sequence ID" value="MST32328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="29196" checksum="EB1D20BCACFCECFC" modified="2021-04-07" version="1">MSSDSGPPSLQRRLREEGAFAVVSPHLDDAVLSCGRLLSENPGAHVVTVFSAGPSSVEPLPEWDAASGCFQPGDDVMALRAVEDDRALGLLDARPHRLGFWDVQYREPPERYGRLGGWRRRSRTSRARDARLVAAVGTALESLVAELPLRTWIVPLGLWHADHKCTARACLELAGRWTDRHWVVYEELPYRLEVPDEAAAARHAIESAGFLCRSTELASGESRKAAALQRYVSQIPCLGDRVEAATSGAEVYHELLPAGRPLTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX2</accession>
    <name>A0A7K0JQX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="8053" checksum="977D59CD7849C031" modified="2021-04-07" version="1">MRTIYLRNVPDEVVERLERLAARERMSVAAVAVRELEEVSRRVDNPALLGDLPDLGIDPVSVVADVDAGRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ3</accession>
    <name>A0A7K0JQZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase SNF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_06405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000277">
        <property type="protein sequence ID" value="MST32352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="572"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="859"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111133" checksum="85B2D99350106426" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR04</accession>
    <name>A0A7K0JR04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="49"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="503" mass="51416" checksum="AC887B89AE1B7B41" modified="2021-04-07" version="1">MSKTRGAARADLDAEARVATAEADRRRPVPAATSRREEHPAGSWLSRLRLPLILVASFMMVLDFSIVNVALPSIQRDLRLPASLDDWVVTAYAITFGGLLVLGGRAADLLGRRRLFVVGLTLFSLASLSGGMASDAVMLLVSRAVQGIGAALTLPAALSLITTGYPEGRERARALGLYGATASLGFVAGQVLGGVLVQLTTWRSVFLVNVPVGLVTVVLALGAFRATESGRLDAALRRLDLRGAILITGAVALAVFAVSEGVVLGWGSPLVIGAVAVAVAATVGFVAAEARHPEPLVRLSMFRHRGLRDGSVVALLLGLWNGGEMLVLSLYLQQDLHQSPLLAGLVIAPQGAVGFLAGIFGASIARHVGGTRRLLAITGAAAAVGFLALTQLPAHHYDAVLWAVTLVGFGTAGTSFGSIVVASDGMADADQGLVGGVINTARQVGAAVGASLLPTVAVAAGGHLGMAAVSGDRAAMAVGAVAAVLATAVAWRRHAGRPQTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR06</accession>
    <name>A0A7K0JR06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_06375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000275">
        <property type="protein sequence ID" value="MST32347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="523" mass="54334" checksum="A3D434D65048522E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR11</accession>
    <name>A0A7K0JR11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1269 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009200">
        <property type="entry name" value="DUF1269_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06897">
        <property type="entry name" value="DUF1269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17434" checksum="1127A9DC5C8F9B55" modified="2021-04-07" version="1">MPKTESVFVYIGTYPDEETARSDYQIVKELHSAGAVGNYDAAVVTKDTHGKVHVNKDETATRHGAWGGAAAGAVVGLLFPPAMLASAAVGAAVGGVGGHLWRGMSRADVKEFGELIDTGEAALVIVGEDKLEQAVTKAALKADRHVAKQLDVSPEEVDDAVRAAAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR13</accession>
    <name>A0A7K0JR13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000283">
        <property type="protein sequence ID" value="MST32386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="29242" checksum="7B668C1A87E4C887" modified="2021-04-07" version="1" fragment="single">MSTYGPRPVTFVRGEGTRLWDDGGKEYLDFLCGISVTSLGHAHPAVAEAVCEAARTLLHVSNLFWTVPQQEVAATLDELLGGGGAVFFANSGAEANECAIKLARRWGGRGRHTVVSAYGSFHGRTLATLHATGQPSKHEPFQPLPEGFRHVAWDDLDALDAALDGSVAAVLLEPVQGEGGVNVPAPGYLAGARRLCDERGALLMVDEVQTGLGRTGRWWGFEHDGVRPDVVTTAKALGNGVPIGACWARADVAAAFQPGDHGSTFGGQPLAASAARAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR48</accession>
    <name>A0A7K0JR48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000287">
        <property type="protein sequence ID" value="MST32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="550" mass="59707" checksum="64743BD40A8A351C" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR62</accession>
    <name>A0A7K0JR62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ORF">GHK86_06760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="17472" checksum="6BF7FF4FA850D9FF" modified="2021-04-07" version="1">MSNGNHVSITGNLTRDPELRFTPSGQATASFGVAVNRRWQNRQSQEWEEATSYFDVVCWGQLAENTAQSLGKGARVVVTGRLDQRSWENQEGERRSKIEITADEVAPSLRWATMTITKNERRSPEGGGGYGSNGNSSAPRAQAPAGESAGTYQYEEEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB5</accession>
    <name>A0A7K0JRB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="21513" checksum="0B51C89883C86EE6" modified="2021-04-07" version="1">MSNAAGQPDTMRERILDVALELFIQNGYDGTSLREVAERLGVTKAALYYHFASKDDILMALHLRLHELGKDALRRLTDGHVTLAKWGALLDSLLDEMRSHREIILLHERNQAAFEKLHRKDHDAEHEDIQDRFRQILADASLPLRDRVKMACSLGAVMGGLLMFGDAFGQAQESQVDDLVRSAVKDLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF2</accession>
    <name>A0A7K0JRF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000321">
        <property type="protein sequence ID" value="MST32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029689918" evidence="2">
        <location>
            <begin position="30"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="41230" checksum="B3F17397F3460683" modified="2021-04-07" version="1">MSKRKSALAAGVVGLSLTLAACGASTSNATSGGSTSSGPSASAGGSGASSGGSTVDAAKATSLAAFGGMSGLVKAAREEGTLNVITLPKDWANYGTIMRDFTKKYGIKIVDANPDGSSQDEINAMEQLKGQSRAPDVLDMGTSFAVEAAQKGLLAPYKVSTWNDIPAAAKAPNGAWYDDYGGYMAIGYDPSKVKVAPTSFKSLLNPAYKNMVAINGNPTQAGAAFAAVYAAALANGGSYRNIEPGVQYFKRLKQVGNFVPVTAGPSTVQSGQTPIVVWWDYLQASEIKSEVKNWKIVIPTDGHYAAYYSQAISATAPHPAAARLWEEYLYSTVGQNLWLAGSARPIELPTLVADGTVDKAALDALPPAPAGAVTFPSQAQLTQAENVVNQQWSTVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG8</accession>
    <name>A0A7K0JRG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="212" mass="22928" checksum="F7D9F657113D29DC" modified="2021-04-07" version="1">MSVGNGLPTGSDPPAAVVHQALARTIAAGTARVQEPGGVHGVIDFEIPAERLFSPGQTIPVVAIPTYTESVMYGHTQYLREVARNPAKQASLERADPFATRWRRQPITDTALTPLVDEIGGPGGTYRYSGRSTFGGQAVAVYTITRPTATFQGMTVLEPRVVVLVNSDGRIVRYSLTQSERDKALHLYSKRTTTWVAFSDFGTKISISRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI5</accession>
    <name>A0A7K0JRI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Benzoyl-CoA-dihydrodiol lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000326">
        <property type="protein sequence ID" value="MST32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017633">
        <property type="entry name" value="Benz-CoA_dihydrodiol_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03222">
        <property type="entry name" value="benzo_boxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="558" mass="60956" checksum="549935848928E016" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI6</accession>
    <name>A0A7K0JRI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endolytic transglycosylase MltG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="7" type="ORF">GHK86_07280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000319">
        <property type="protein sequence ID" value="MST32523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="273" mass="28974" checksum="3676DA67C02AB401" modified="2021-04-07" version="1">AWYVKLEGLGPLYAGTYHLPTGERYAEVVQRLETAPAVPVDTLVIPEGLTLRDIAARVAALPGMHISAASFLALSSSGAVRSPFEPAGVDDLEGLVFPATYQIARTDSATDIMELLVQTFVQRASALDLSQAAAQLHVSPYAVVEVASIIQGEAKYLSQFPDVASVIYNRLQAGMTLGADSTLVYALRRKDPGINVGKIDYNQPNPYNTRLNKGLPPTPIDNPGATALAAAARPPHTDLLYFVEIAQDGKLGFASTSAGFDQLVATCHAHGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ2</accession>
    <name>A0A7K0JRJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000332">
        <property type="protein sequence ID" value="MST32566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="237"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="35509" checksum="068F446E6C94390F" modified="2021-04-07" version="1" fragment="single">MKPTDIDETARRAGDVLDRVSEAVVGKRDELRLVLAGILAGGHVLFEDVPGLGKTLAARSFAQALGLSFRRLQFTPDLLPADVTGGVVYDQRQGTFEFRRGPVFTNLLLADEINRTPPRTQAALLEAMQEHQVSVEGATHRLEQPFVVLATANPIEYEGTYQLPEAQLDRFMLRVSFGYLTPELEWEVLARRVGRRQEDTRVDAVVDAAGLRGMQAAVETVDVEASVGRYIVDLVTATRRRPEVLVGASPRGALACMLCARAWAVIDGRDFVTPDDVKAVVGAALAHRLTLRPETYIRRVDSGDIVRSVLAEVPVPETAGRPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK5</accession>
    <name>A0A7K0JRK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000326">
        <property type="protein sequence ID" value="MST32547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="220" mass="22456" checksum="A0D9EB10A16CC174" modified="2021-04-07" version="1" fragment="single">MPPSRRPPTAGSSGPTSSSGARTPGCPPAPTASTSARSCSPSTRRAASRRGWRRPSRASTASPSRSTTSTWPDTLRTVSGGRFNASEYLLDRRLDAGDADRLALTGVGGELTYAALHDLVGRTAAGLRRLGLLPEQRIVLFMADGPEFAAVYLGALRMGAIPVPVSTMLRADGLSELLVDSRARLLAVSAEFAGVAAAAVTAAPELAGVVAGTGASVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM8</accession>
    <name>A0A7K0JRM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1003 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000336">
        <property type="protein sequence ID" value="MST32585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="13498" checksum="0824843F605A22FA" modified="2021-04-07" version="1" fragment="single">MARPRGTTVSIGAHVDPETFGRFSETIARYFGTARFLAIQTVVVAAWIVLNITGFVRHWDPYPFILLNLLFSTQAAYAAPFILLAQNRQDERDRLSIERDRQVAARTQADTEFLARELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS3</accession>
    <name>A0A7K0JRS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000348">
        <property type="protein sequence ID" value="MST32635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="274" mass="29670" checksum="88487780241E8D30" modified="2021-04-07" version="1" fragment="single">MAERTGAQRLRVGFWRHVRYGRVLAEGVIVGDVLSAVEKEAVGSWAAATRSTVARPSTRDRFLQVHSERAFVAEILYRRAIRGRPYRSHATQRDGLARGATIVCWDAAFVLSRFCLYESTALSGVYRGGLSMALAGRPAPAGSGRPWQDRPGFPRLLARQLNPEVTMVGWAGDRLMVADGVLPGWVVDLGHLGRTLTGGGDGGFAGFCAAFGVDEPGSAPAWQPGDPPEGMLRWGRARLDAEIGLHEAFMGEVDTWRDGGARRVRPPWLYSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT9</accession>
    <name>A0A7K0JRT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="245" mass="25512" checksum="F2EB757163AF5CFA" modified="2021-04-07" version="1">MQSADSAPIDADSRHPAAGRRSASSAAVLGLPSRHMATPVAAGAGHLAAPARGSMIATRRSLARVAPRFATFDERHHRHDGEVSVGLAGEDDLAVLAQLAEAHSGVTGGWGERLRADLSGVGRALFVARVEQAVAGYGRVRWFSPPPGSAADTAPAGWYLAGLLVAPDRRGWGAGAALTRARVGWVAERADEVWCYANARNAVSLALHAAIGFEEVTRDFSVPGVSFEGGVGMLGRLRLRPVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY6</accession>
    <name>A0A7K0JRY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DksA C4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000365">
        <property type="protein sequence ID" value="MST32701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="72" mass="7671" checksum="4498C6FF7C4DBBAD" modified="2021-04-07" version="1">MSEGQAADPTADVALLEEAEAVLEGLDVALRRLEDGSYGTCEICADPLDREELRARPLSRRCASHAAGRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC4</accession>
    <name>A0A7K0JSC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000406">
        <property type="protein sequence ID" value="MST32842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="31665" checksum="A93716D3A0346806" modified="2021-04-07" version="1">MPVADQPLAPTPEQVERYRADGFLVVEDFLDHEELLALRRRWGPLFDHTWATGIAPDEVNYTSGVTPPDRTRQLCNAWKADPVVAATTLSVRNASFAARLAGLDGLRIGQDNLIWKPPSGKALLAHQDGAYLDWMVPPNMTTCWVALDDTAADTGTIYYVRGSQRWARSPVGGQFHAPDDWLGYLRDVAPPGVELELVPIEVPAGGAAFHDAWTWHGSPPNERADAERRAIISHFIDARTRWNPDVAHEVYSRYRRPGETEMDEAFFPVVWRSDGYRTPWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG3</accession>
    <name>A0A7K0JSG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alkyl_sulf_dimr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000418">
        <property type="protein sequence ID" value="MST32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl_sulf_dimr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6715" checksum="FFDB58372A36BDF9" modified="2021-04-07" version="1">MRLACHLVEFAVLADPASAAAHAARAGIYERRAAAQTSSMARNILRHAARSSAQGQRDITPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL1</accession>
    <name>A0A7K0JSL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_09360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000432">
        <property type="protein sequence ID" value="MST32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="48877" checksum="6CD38067B5B7DAD8" modified="2021-04-07" version="1">MATALSAYSIRLRARIRNRPGVLGGLATAIGGAGGSLMAIEMVATDGATVTRDLVVFCPSEAHAGDVEAAARQVEGIEVLEVEDRTFALHRGGKVSIEPRRVLKDRDDLAMAYTPGVARVCTAIATDPALVHRYTMKANTVAVVTDGTAVLGLGDIGPDAALPVMEGKAVLFKAFGGVDAVPVCLRVDSADELVDTVRRLEPMFGGINLEDIAAPRCFEVEARLTEALSIPVFHDDQHGTAVVALAALRNALRIVDKRMEDLRIVLSGAGAAGVAIAKILLSAGAHDIVAVDRKGAVHKERDGLDESKRWLAEEANQADRRGSLQEVLAGSDVFIGVSAPGLLGREDLETMADGAIVFALANPVPEVLPEEAEGVVAVMATGRSDYPNQINNVLCFPGIFRGALDVGATRITENMKLAAADAIAAAVPPDQVSPALVVPSVFHPHVASTVATRVGEAAIADGVIRSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX4</accession>
    <name>A0A7K0JSX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="17286" checksum="B5B6A3E01F73F8DB" modified="2021-04-07" version="1">MGEGLLGIGEAAARAGVSERALRYWQQLGLIKPTGSTPGGLRRYSEADIARVARLRELQELLGFNLEEIRQVFDNEDRLETLRAEYHAEHTDAARRRELIAEGLAVRGRLRATVVTKLEALQRFLDDLDAQRDRLQRILDEGVPGEAQPAGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ4</accession>
    <name>A0A7K0JSZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="16189" checksum="AD4D2EB81209FF20" modified="2021-04-07" version="1">MAARDRASDDRSTSRLDAVERFRSAFAQACQTEVRPAMEAVIERLRANGGGGLIHQHPGGEPRFRHPSCVAWLSLEGEILGEPRPDRHGYLQIEADVTAREILVSEGDMRQGGGGSRSGRAGSWQLSDLTQERVRAELVEIVRRSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA0</accession>
    <name>A0A7K0JTA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000506">
        <property type="protein sequence ID" value="MST33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="22130" checksum="2CD89592C6E9627A" modified="2021-04-07" version="1" fragment="single">MTEQWAGRALDRARSGAPRRDLYFALLAAVVCLEAVGIGIVFPILAHVQDVHHLATYTLGLMSGASFFAALLAQVTAGPFLDGEKAQRLLLLGVLLGAAGLVWFAFAGGLWELVGARALGGIGYGIVSPAALRQASVGATGARRGKRLGILSSAQMAGFTLGPFFGSVLYAAGGLRTPFEVVGGLLTLVGLGVLLLPAQTRATTVAGADADAAATGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTA6</accession>
    <name>A0A7K0JTA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000400">
        <property type="protein sequence ID" value="MST32824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12020" checksum="0BE4A81BB0D310C4" modified="2021-04-07" version="1">MSVLAYGVVAWLLIIGLYGIVTSRNLIHLVVCISVAQSATDILLLEIGYRTGGRAPVVLDLGHHAGPSVDPVVQALALTDVVIGAAVTALLLALVVQIHKRVGSLDPADIRAEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB6</accession>
    <name>A0A7K0JTB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000403">
        <property type="protein sequence ID" value="MST32834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="10391" checksum="BE26B9E57C0C5AEF" modified="2021-04-07" version="1">MRSIHFDPNAWDDFSYWLGADRRMATRIVRLIEEIQRDPLTGIGKPEPLKGDLSGYWSRRIDDEHRLLYRADDAEVKILEARYHYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU59</accession>
    <name>A0A7K0JU59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="12" type="ORF">GHK86_12150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000605">
        <property type="protein sequence ID" value="MST33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="284"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="433" mass="47301" checksum="0B88CE9CCD0B3237" modified="2021-04-07" version="1" fragment="single">MFPLPGADRPPGRGPGGHRQPLGAREGPGVGIVDEDIARVRAATDFVALASEHLALRRVGTRWVGLCPFHTESTPSFYVNAQEGLYHCFGCQASGDVITFVRELEQLDFVEAVEKLAGRAGITLRYDDETASRDHQRRARVYDTVARAVEWYHARLLEAPDAAAARRYLRVERAYDGDLVRRYKLGWAPDGWEPLLRALKLPRGALVDAGLGSLDEQGRYRDFFRARLLFPIFDPSGRPIGAGGRMLPGGRPPKYKNTTGTAVYDKSSVLYGLNWAKQAIVARNRVVVCEGYTDVIGLQRAGVEEAVATCGTALADGHIRLLTKFAPRIVLAYDADAAGQAAAERVHEWERRFEVDIRVAAFPAGEDPADVARRDPEGLQRAVSDARPLVVGADAHGRAPRQHPGCGDGGVDGGELDDVHERRGYRSAPGWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU89</accession>
    <name>A0A7K0JU89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000621">
        <property type="protein sequence ID" value="MST33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="491" mass="55133" checksum="06F1EF7741D3B89D" modified="2021-04-07" version="1">MVVIGAGPAGLTAAYELIRRGHIPVVLESDDIVGGISRTVERDGWRFDIGGHRFFTKVAPVEEFWHEILPDEDFMLRPRKSRIYYQGKFYDYPLRAMNALTNLGVLEALRCVASYAWVRFRPPEDQTNFEGWVAARFGWRLYRHFFKTYTEKVWGHPGSEMGADWAAQRIKNLSLASAIANALLPKRNQKDITSLIEEFQYPKLGPGMMWERCAEKVREAGGTIEMRHRVVRIRRGAAGATAVVSRGPDGREREDPASAVVSSMPLSELVRVMDPPAPAEVRAAADDLAYRDFLTVALVVPADRVPWNDNWIYIHDASVRTMRIQNFGSWSPYLVKNGRNVLGLEYTVDEGDAAWTAPDDELVEQGKAELGKLGLVDPSAVEAGYVVRMPKAYPYYDADYHRNVDTIRKWIESEVPNVHPVGRNGMHRYNNADHSMYTAMLTVENLLGAHHDVWSVNVEEEYHETLSPAGTGGGARGTGRDAPILPKPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA7</accession>
    <name>A0A7K0JUA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF861 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000503">
        <property type="protein sequence ID" value="MST33164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="42"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="12681" checksum="011CEB938D710DD7" modified="2021-04-07" version="1">MSDDASSRTLTDDALRCRLGAPQPAGTGAVGGEPMAASVALAELGDVEVGVWEMTPGVCHDVEGDEVFVVLSGRGAVRFADGSVVDLAPGRVVRLRGGERTVWDVTETLRKVYVALADASAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD9</accession>
    <name>A0A7K0JUD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000637">
        <property type="protein sequence ID" value="MST33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="17956" checksum="75B2172493E11519" modified="2021-04-07" version="1" fragment="single">MQHAVCGHPGGCHQREGHVVKAARLKTAAIVGAAAMALGACGSSGTATSGGGSGGSGGAALTVAGVIAITGASDFEGQNQAGGILPAIYAINQAGGVLGHKLVYKGVDTRADPADALPAVQQMLATTHNLVMVAGPGSNSAPTIVPVLNAAKVPMTAVAGESAFDRTTAQYFWRLFPPDAANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI9</accession>
    <name>A0A7K0JUI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="20975" checksum="ADBA1E986ED8D5DF" modified="2021-04-07" version="1">MVLRALAMAAAAGMVGACGGGGGGPTSKELAAELLTLKDLPTGWSEQQAANASQGQSLCRISGSLRKDAIATAQRKFGHGILPAVDEFLAGYHRSPSATFDGLIGEIRACHSFGIPGFRFAVGHLQVPTIGTKSYAFSLSGEVRAVSGANVASARVASSVAIRFTFDIVMAEKGNQVLVLVYGATGTPPATEVTALATKAASRIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT2</accession>
    <name>A0A7K0JUT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000697">
        <property type="protein sequence ID" value="MST33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="225"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="424" mass="46990" checksum="38720541FD25F882" modified="2021-04-07" version="1">MSVFGLQRRAGERHRRPWVVRWAVTGRQRSRSFRTRAEADRYRTALLVAVQRGEPFDDSSGEPVAWQPLPDDLRAHHWARRWLAEQWPEWAPRTRVSAVEALSRLLPLLVDPSAAAPPPSLRRHLTATLPPTPGTGDPDAERWLDRSILQLGQLTRPLLAAVDQRLGVADDGTALGAATAGRFRKVSRACIRRAVELGVLDVDPWPPAARGRSSRKAARTRRQVSIRQLPTPQTMAKVLDAMPSHQPASRTYQVMTAVAYYAGLRPSEVVMLRADALELPDDGWGRLYVTEADVSFDEPGEPKTGPRSVPIPPRLVVMLREWVGAGGHRGQDLLFRTRTGMRPRASNWSRALHRALAACDAPPMRIYDCRHAAATTWLRAGVPLGDVAKRMGHSVETLVSTYVGALEGDEALANARIEAVLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUU5</accession>
    <name>A0A7K0JUU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-IB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000692">
        <property type="protein sequence ID" value="MST33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="29878" checksum="601C0C86B3537CA4" modified="2021-04-07" version="1">MEAAFFDLDKTVLAQSSMMAFAPAFFRAGLLRRRNLLQGAATQLVYVRWGAGPHRVARVQKSVLSLTCGWDQAEVRRLVGAGLGDAIDPITHAEAVALIAEHRAAGRRIVLVSAAPEELAEPIGARLRVDTVIASRAVLDERGCYSGRLERYAYGPAKADLIRELARREGIDLDRSWAYSDSITDLPMLEAVGHPVAVNPDRRLRRIALLRGWEVARFELRPDPEPVAGNPQAPTEPAPVAEPASRRGLRRAPALALAVTGVLTAWWYRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW2</accession>
    <name>A0A7K0JUW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3492 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000707">
        <property type="protein sequence ID" value="MST33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3492" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="479" mass="51595" checksum="4626B709F26CB413" modified="2021-04-07" version="1">MQIALIGEGAYPHQFGGVSVWCDQLVRGLPEHEFHVVALVATGQEPVRWELPGNVTEVTTIALWGRTPFRPVLESRARRRLLPAVEALLETLVGPHEEGDAAFASALRELAGSAQHTPLAPGLCSDDAVAALSALWRAHRDHDGLPELTLHDAVTVLRILEHSLRPLAHPPLEADVCHIVTNGMAALPGLVTAWERATPLLVTEHGIYLREQYLHSRASPLRWPVKDLMLAFARRLCTAAYGEAATVAPGNAYNRRWEERLGAPPARIRTVYNGVDPAGFPLAESEPDVPTIAWAGRIDPVKDLETLLRAFAAVRRVVPEARLRCFGGTGPGGAPYLARCEALAAELGITDAVRFEGRVADIREAYLAGHVVVLCSITEGFPYTLIEAMSCGRACVATEVGGVPEALGDAGLMVPPRDPDRLAGACVALLQDEALRHRLGAAARARILGAFTLDQAVTTYDEMYAFLGRGRDMPTAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV32</accession>
    <name>A0A7K0JV32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000736">
        <property type="protein sequence ID" value="MST33816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16837">
        <property type="entry name" value="BldD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038099">
        <property type="entry name" value="BldD-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037664">
        <property type="entry name" value="BldD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="19829" checksum="B0732A2E66987E26" modified="2021-04-07" version="1">MPSSYARRVGDRLRSVRQQQRLSLQAVEVASGEEFKASVLGAYERGERAISVPRLQRLARFYNVPVDQLLPRDAGGEVGWERAESTPTELEGDDGVTIDLTQLESLGVPEGHTLARYLSTIQVQRQDFNGRVLTIRREDLRALAALFDVSPDEVRRRLDDLGLRRVHAASDGFSRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV45</accession>
    <name>A0A7K0JV45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000715">
        <property type="protein sequence ID" value="MST33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="8731" checksum="75FED1CA23E7B70A" modified="2021-04-07" version="1" fragment="single">MVDARYEWLEGPPVQGATPEAVPAATVVALRGGPAGLEILLVRRRRGGAFSGLWVFPGGRVEPADAAGAVSRPDDPPGERGGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV99</accession>
    <name>A0A7K0JV99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_14215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000754">
        <property type="protein sequence ID" value="MST33868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="20603" checksum="6EE44AB9A00F9AAB" modified="2021-04-07" version="1">MPAAAPGERRVLTIPNAFSAARLACVPIFVALLVQPDRRDWFPAAVLLGALGATDWVDGFLARRLGQVSTVGKVLDPAADRLLLVTAAVGTVALGAVPVVVAAVALAREAVVAGGFLYVAAAGGRRMDVHLVGKAGAFGLMCALPLFLAGHSAVGWHPAAEILGWVFAVPALVLAWASVTIYVPAARRALAESRSPEGSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH2</accession>
    <name>A0A7K0JVH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_14620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000785">
        <property type="protein sequence ID" value="MST33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="24639" checksum="3B2003918A6FE37F" modified="2021-04-07" version="1">MLKIKHEPKQLVDVTAVPALLTILFTYLFGGALGGSPRHYLTVLVPGTMVMGVTIVTMYGGARLADDLSTGVFDRFRSLAVWRGAFVVGGLVADIGRYLLAAGIVATLGVAIGYRPGGGVPGVLAAVALVVAFGVSLSWVWTVVALVILDSATVMSLASVVVFPLTFASNVFVPARTMPGWLQAFVDANPVSHLASASRALMNNTGGAGGPVIWSLVATGAITVVFAPLALRLYSKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR2</accession>
    <name>A0A7K0JVR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000796">
        <property type="protein sequence ID" value="MST33982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="212" mass="22434" checksum="C6CD4D557FF0E5EC" modified="2021-04-07" version="1">MGVDHVGAHRDAERTRDRILDAARAAFARHGYDGTTVRTVAADAGVAPNLITRYFGGKPGLFRAATAAELGVAAVLPGPVEGLGARLAANVVRRWEGVEPEDPLLMRLRSAGSSDAAARELGEFFQRQACSPLAAHLERVLGCSRPDAEDRVAAVGALIMGLVTSRYVMRIGPLFAAEPPALEAWLAERIQRLLESPAPALACPPERSPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS4</accession>
    <name>A0A7K0JVS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ala_racemase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000675">
        <property type="protein sequence ID" value="MST33654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="2">
        <location>
            <begin position="110"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="21702" checksum="451246D6C63EE794" modified="2021-04-07" version="1" fragment="single">GQRCAVVLAEPLEHPSRESAQAFAAALVSEGASAVFGLALPSHEVVAAALAALDPAAEVRLLGDFDRLREWLVAELHAGDVVLVQSPPERGIGDLTVALMESMAPTRLYLDLDNLEDNVTSFRRIVGPSVRIMGMVKALAYGTDAASVSGVLQAAGVDALGVSGVDEGVALRRAGIAVPILVLLGTAAELPKMLRYRLTALVYGPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVY4</accession>
    <name>A0A7K0JVY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000857">
        <property type="protein sequence ID" value="MST34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029613851" evidence="2">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="17748" checksum="D7F4391E88C74D2D" modified="2021-04-07" version="1" fragment="single">MRIKKASALTALIVAGSLAAAGCGSSSSNAGSKTSGSGTSAAATGTSGSSTSGSGSSGSSTSGSGSSGASATLSATSFTNSFSAMANLKSLAAKGKGKIAVILPDTTSSARYVEFDAPYLKQAFEAAGLKPSQFIIQNAHGSDTTAETDAQADITNGASVIAIDPEDPAGGLAVTKYANAHGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW11</accession>
    <name>A0A7K0JW11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000863">
        <property type="protein sequence ID" value="MST34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="95" mass="10315" checksum="DEEE892A4E29B398" modified="2021-04-07" version="1">MVHAFVLIDAVPSRVAPLATELAEVDGVAEVYSVAGHADLVAVVRVRHHEELADVVTRRIHALEGITDTRTLIAFQAYSRRDLEALWDLGDDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW92</accession>
    <name>A0A7K0JW92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl Co-A mutase-associated GTPase MeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">meaB</name>
        <name evidence="2" type="ORF">GHK86_15995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000899">
        <property type="protein sequence ID" value="MST34217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="25441" checksum="5993AA4400A08C79" modified="2021-04-07" version="1" fragment="single">MPPADPQALLARAAAGERRALGRLLSMVEAGGERAQQVARLTFPLSAAVEQVVGLTGAPGAGKSTLTSGLVAAARPAGPVAVLAVDPSSPFSGGAILGDRVRMQDHAGDPGVFIRSMASRGHLGGLALAVPEAVRVLVAAGFPRVLIETVGVGQVEVDIAGAADTTVVVVTPGWGDSVQAAKAGLLEVADVFVVNKADRPGADGARRDLAAMLDLDPDPGGWRPPIVLTDARSGDGVAEVWAAVGEHRAWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA4</accession>
    <name>A0A7K0JWA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000739">
        <property type="protein sequence ID" value="MST33829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="19305" checksum="2FB2329234ECDD2E" modified="2021-04-07" version="1">MTWAYQQPTTWSSADTTGETRTTTAPLAAAAVALIGAWAAIAAFVGPDFGYRVTTGAAWRWSTRNWMLHLAPGGAALLAGLLLIGLAASRGAKVLLGLLVVAAGAWLVIGPAVWGWLEGSAPYVAAASARASFLHQVGAALGPGLLLAALGAYLLSRPSVRVVRRRRTTRTEPTPSTAAPAAAEPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR9</accession>
    <name>A0A7K0JWR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">GHK86_14955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000811">
        <property type="protein sequence ID" value="MST34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="204" mass="22108" checksum="E4D0A6EBA66587EB" modified="2021-04-07" version="1">MIPTVLDQSARGDRAYDIYSLLLRERIVFLGQEVDDQIANLLVAEILYLDANDPGQDIFLYINSPGGLSYAGMAIYDVMQHVRSEVSTVCVGMGMSAAAMILCGGAPGKRYATPNAKIMIHQGSAGSKGAPRDMEIQLREVLATTRRMAEIISFHTGQPLERVERDIDRDYYLSAEEAKAYGLIDEVISPQRGLAALPVGAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS0</accession>
    <name>A0A7K0JWS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exosporium protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000947">
        <property type="protein sequence ID" value="MST34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="6042" checksum="81356101FE8C9960" modified="2021-04-07" version="1" fragment="single">MQRGGEGDQVLPGAGRHARPGRVGAEPGERILEPAGPTGATGPTAGAGTTAGAGPAGPTGATGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU9</accession>
    <name>A0A7K0JWU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_17060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000998">
        <property type="protein sequence ID" value="MST34423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="235" mass="25003" checksum="5241405F1DF8FC90" modified="2021-04-07" version="1" fragment="single">MRVAVVNAGSSSVKLRVVADGVVADAVDLGPPGDRLATQLDAYLDAAGDLDATGHRVVHGGDRFTRPVVVDDAARAELDRLEDLAPLHNPPATRAIDEIRRLRPALPVVACFDTAFHATLPAAARTYALPAEWTERFGVRRYGFHGLSCQWALRRAGELSGRDPDRLRVVVCHLGGGASVTAIRDGRSADTTMGFTPTEGLVMATRSGDVDPGALAWLVEHGVDAAELGDALERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX11</accession>
    <name>A0A7K0JX11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001031">
        <property type="protein sequence ID" value="MST34487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="33834" checksum="EA113090C990BE01" modified="2021-04-07" version="1">MLNGAWKPAPTPGYALRRSQLHLVTTLPADAGRVVADGDLYLVRSRVIQRLDPASGQVLASARTPKVTAPPFRAGHGLWLAAGSQVVELDTTSLRVEHRFSAPGTVTSLAVAGSSLWYVVPANGRDGAAGRLYRQPLQGGHTTAVAFPARTDPGSHGSPVSAVMANAAGTQLAVTFAANITMFARLDPATGAVLARYQLQADNVIIDGIAGDIAWVVGGVGHNNVLAGVDLRTGRPRPITGTAPASLAPPGTNGQGGWLQLTGQTLIETFLGAPDACINPATGRARSYLTLPAGLDLAGIADHRLIADTTTITGRTTRLLETSVPGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ7</accession>
    <name>A0A7K0JXJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001148">
        <property type="protein sequence ID" value="MST34685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="9180" checksum="9B237D082737AD75" modified="2021-04-07" version="1">DAAELRREVLGALRPDGVAWSPAETAAVDDLLLRVGRLVEELPEVDHLDLEPVVVSPGRAAIAGIRVHAQVPEPHPERALRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK1</accession>
    <name>A0A7K0JXK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001144">
        <property type="protein sequence ID" value="MST34677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="9151" checksum="877D279C0D496957" modified="2021-04-07" version="1">TSPEEARILTEGGPRLLGDLLAAGLLDELCLTHSPFVAGPDRVRLCQGWGPTPDPGQRRFRLEAVHAADDRLFTRYRLLRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL3</accession>
    <name>A0A7K0JXL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000924">
        <property type="protein sequence ID" value="MST34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="12716" checksum="873049202B7074C1" modified="2021-04-07" version="1" fragment="single">MDAARRQAGPLLPVLRALQEAFGYVDPRAVPLVAEALNVSRAEVHGVLTFYADLRTEPPGASVVRVCRAEACQAVGAEGLVAHACERLGIGLGATTSDGAVTLEQAFCLGNCALGPSVMLDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ4</accession>
    <name>A0A7K0JXQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001190">
        <property type="protein sequence ID" value="MST34745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="15295" checksum="1D110E15A900570E" modified="2021-04-07" version="1" fragment="single">MLSVHRGGRTLATRPAGERPSRGGRGSAGQNGCVVRPWKLVGNRPGSAGFLPLSVGTYELPDGTEADWDIYGFAAVVAVLALTPEQEVVLARQFRPGPGLVLDEMPGGIIEDGEEVLAAAARELLEETGFAADLELAGGTWLAGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY24</accession>
    <name>A0A7K0JY24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001267">
        <property type="protein sequence ID" value="MST34868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="47" mass="4651" checksum="F04309D503A50129" modified="2021-04-07" version="1" fragment="single">MSDLPDPERPDQDRGATGPALRVGVVGAAGRMGATVCAAVDAAADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY31</accession>
    <name>A0A7K0JY31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001259">
        <property type="protein sequence ID" value="MST34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10275" checksum="BA2C7CC173312118" modified="2021-04-07" version="1">MAEAPARSGAAVTIAADDAGVTLAPRAHVPRISALPRPELAAVLADVSWLTTELRRRSGAEVQVGTVRGPHVTLRLTVDGPGLPPSAVRDVADGLVDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD0</accession>
    <name>A0A7K0JYD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001334">
        <property type="protein sequence ID" value="MST34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="376" mass="40234" checksum="6F4C353EF15AE52A" modified="2021-04-07" version="1" fragment="single">MMGTRWFTSADCDLEAFRAVVEQDTRLEDYPHADAVEGNVVVYGERLRGVEDRRAAQAELVQALADGPGVVVFRGAFDREVVARATAVFAALLGEQEAAGGAGGDHFAAPGANGRVWGALDKLALRAPDVFADYYANDLLALVAEAWLGPGYRVTSQVNVVRPGGTAQHPHRDYHLGFMDRERALAFPAHLHALSPALTLQGAVAHVDMPVETGPTLYLPHSHKFAAGYVAWHDPAFAAYFDRHRVQVPLAAGDAAFFNPAVFHGAGTNASAGVMRMANLLQVSCAFGRPMEAVDTVAACRAVFPVLAARRAAGVPDRAVRNVVAAVAEGYPFPTNLDRDQPVDGPTPPTQADVLWRAVAEGWEPDRLQDELTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI6</accession>
    <name>A0A7K0JYI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_20120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001368">
        <property type="protein sequence ID" value="MST35023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="14484" checksum="569EA5B149555C96" modified="2021-04-07" version="1" fragment="single">MPNFNDTATTPTEEMREAMRRAEVGDDVFHTDPTVNELEAAGAAILGHEDALWVASGTMSNLCAVLAATRRGDEVLAEADAHIVYYEAGGMATVAGVMPRTVPTPDGVLDADGVRAHLRPPDHHFPPTSMVCVENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ9</accession>
    <name>A0A7K0JYQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001145">
        <property type="protein sequence ID" value="MST34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9299" checksum="FCB8A00B51C3CE4A" modified="2021-04-07" version="1" fragment="single">MTALVKLVVFVPEDAADAVRQALGAAGAGDIGAYSWCSYSARGRGRFLPGAGAVPHIGTPGRMETVDEERIEVTCRRDRARAIAALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS7</accession>
    <name>A0A7K0JYS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGAR-AT_linker domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001427">
        <property type="protein sequence ID" value="MST35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="1">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="7083" checksum="C54BEAEBA09350B5" modified="2021-04-07" version="1" fragment="single">MTADASLHRALGLTDDEAAAIERLLGRAPNHLELALYAVMWSEHCSYKSSRLHLRRLPTEGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT6</accession>
    <name>A0A7K0JYT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001436">
        <property type="protein sequence ID" value="MST35106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="12096" checksum="1FCC0E7F1668ABDB" modified="2021-04-07" version="1">MVEGRRHWTFLTNHGHVLICIARDPGIRGRDIADRVGITERAAQAIVADLIEAGYVQRTREGRRNRYEINPDLPVRHPVEQPHRVGDLLAAMAGDADLQTTTAAEPPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT9</accession>
    <name>A0A7K0JYT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001387">
        <property type="protein sequence ID" value="MST35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="23085" checksum="6C16D09FD0031CA0" modified="2021-04-07" version="1" fragment="single">MRAATAAVAELFAAVPAQQEAVAALRSAASRPVHAYLLVGPPGTGKLAAARAFAAALLCPAGGDASCEVCRRVLDGVHPDVVVVEREGASISIDAARAVSRLAARSPVEGDRKVLVLQDFHLVRDAGPALLKTIEEPPPSTVFVILAEHVPPELVTIASRCVRIDFRPLPVGAVAELLAAEGVDPEHAAELAEVAGGRLDRARLLAADPEFAARRRAWRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV0</accession>
    <name>A0A7K0JYV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001458">
        <property type="protein sequence ID" value="MST35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3D" evidence="1">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="14711" checksum="321291CC851B8599" modified="2021-04-07" version="1">MYAFGDARFHGSGAPEPASAAVTALAATGPAGYLELTTAVRTPPVRTRAATAVAGVSLGDFVVTCYDLRGTTASGAPVSMSTVAVDPSVIPLGATIDISGVGVRVAQDTGGAIVGHRLDIWEPTYQDCINWGVRTEHVTLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ08</accession>
    <name>A0A7K0JZ08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_20985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001509">
        <property type="protein sequence ID" value="MST35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="22251" checksum="DC2F8BC534BAA7CE" modified="2021-04-07" version="1" fragment="single">MAGAAGAASAARRRPLALAILCSLLFLTFLDNTIVSVALADIQTSLHAGVTSLQWVVNGYALVFAGAMLACGMIADEFGRKVVMLSGATVFCAGSVLCALAPDVGVLIGGRAVMGLGAAASEPGTLSMLRHLYPDRGQRDRAIGVWAAVSGVALAVGPVVGGVLVGAFSWRAVFWFNLAFGAVVVLAALAVLPENADPEARRVDTAGALLGAGALTAAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ39</accession>
    <name>A0A7K0JZ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_21200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001539">
        <property type="protein sequence ID" value="MST35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="32889" checksum="DE3B0206C7DDF941" modified="2021-04-07" version="1">MLLLGLSLFIAAGLDPMVAWLHRRMPRPLAVLLVILLGLLLTAGVADLVVPVLVREITALVNALPHYFKELNDKSSFIGRFNDRYHVERTIRDALTKRSSSIATGILGVGRAVLGALASTVVVMVVSIYLLFDMPRFKRLIYGLAPRSRRARTVLLGDQIFAKVGGYLLGNIVISVVTGLGTWVWCVIFGVPFPLLLAVLVALFDLVPVVGSTIGGIIVAGVSLTVSLPVAIATVGFYLLYRFLEDYLLAPRIMRRTVDVPGLVTVVATLIGGVLLGIIGALVAIPVAAAVKLLLEELAAPRLEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ55</accession>
    <name>A0A7K0JZ55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001555">
        <property type="protein sequence ID" value="MST35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="131" mass="14035" checksum="75F4C572B9DEC1A4" modified="2021-04-07" version="1" fragment="single">VLASFAAALDALGVRDRSERSRMEAYVRATMGESKIVVFRALFDDEARAQAANTAFEAAYDERIEAGAVAPIPGAEDTIAALRRAGRKVALLTGFSAPTRDRLVARLGWRSAVDALLCPAEAGRGRPYPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ69</accession>
    <name>A0A7K0JZ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2088 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001506">
        <property type="protein sequence ID" value="MST35193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="431" mass="47994" checksum="08A1DFDEA793DBE5" modified="2021-04-07" version="1" fragment="single">AGVDDVVLIAALALHRRMTEAELRHALGDRVYDAFAPHGRLLQHDAEDPEGLVHLGVTDHGEDVEINRRAAESDLLVYVNINLVSMDGGHKSVATGLASYRSLRHHHNVRTMRHSRSFMDQHHSELHSANWRMGRLIAASGVKVFQIETTLNNDAFPSQLGFLQKREWEWNGRDRAAYLATTAALRAGSERLNRSVFQSVKAPYAMTGVFAGEVEAVHAATTEAVFRQQLVPVEGQTDVAVYGLPHISPYNVNSIMNPILVMCMGLGYLFNLYRGRPIVREGGVAILCHPTPWAFHPVHHPSYIDFFEEVLAETTDPLEIEKTYEERFATDEWYRHLYRTGHAYHGVHPFYMWYWGAHALEHLGRVIIVGGDPAAVRRLGFMPASTLDDALEMASDVVGRQPTISHLHCPPRTSSACAPPTSPTPTTSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ97</accession>
    <name>A0A7K0JZ97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001281">
        <property type="protein sequence ID" value="MST34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="11597" checksum="DCE822B8FBF2D7EC" modified="2021-04-07" version="1" fragment="single">MVLRGGRVIDPGTGTDRVADVALDGGRVVAVGAGLTGDAELDVTGLVVGPGFVDLHSHVHSIAGHRLQALDGVTTALDLEAGVMPVARGYAAAADEGRPLHYGFSASWASARGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI2</accession>
    <name>A0A7K0JZI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001589">
        <property type="protein sequence ID" value="MST35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029691927" evidence="1">
        <location>
            <begin position="38"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="32754" checksum="00FE87C80FDC1503" modified="2021-04-07" version="1">RATRAAYPRHPRRLAGLLAATVALALLATACGAPARAASTKGAPVVTVVTGLWPLQQAIAAIGQGNVRAVDVVPAGQDPRTWRLDGGARSRVRSADLVVELGGGWQPTLTAAARGARHVLDLSRAIPHLPPYPWLNPYTMESIARAIAASLDRVDPQAKGTFANGEQDEQALLGSLDADFQSTLGSGGCATQNLVNSDQAFTALDTRYQVHVVPIDGATPAPFFPDKATVAHELQVVRRAGVHEIYYDTWQKQDGLLEVEAEAQVKLGTLDPLTGIPPGGWPKGLKSYLNLMEYDLGAITNALGCPQPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZJ0</accession>
    <name>A0A7K0JZJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001651">
        <property type="protein sequence ID" value="MST35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14594" checksum="C166E242A53860EF" modified="2021-04-07" version="1">MVDVAVLGLPSRGVRAVDARRLTARARERGAVLLLLPDPIPVGRRAGWLPRAWPEPPELRLGAEAAVWEGLGQGGGHLRARALTLTALGRRGASRPRSVEVWLPGPDGRVAPRTAGQGSRQAPGGAESGAARRLADAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZS3</accession>
    <name>A0A7K0JZS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001414">
        <property type="protein sequence ID" value="MST35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="17765" checksum="F6A2057BC9211B84" modified="2021-04-07" version="1">DRAAVGAWIDAELDWLRALDRRGVPVLGVCFGAQALATAHGGAVEPAPRKELGWVAVESSQPDLLGAGPWFQWHGDRCVAPPDAEVVARTEVAVQAYRVRRNLAVQFHPEVDRAQLLRWLEHGRDELAAHGVDPDQLLAATTAEEPAARARADGLVDAFLRITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0R2</accession>
    <name>A0A7K0K0R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1206 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001658">
        <property type="protein sequence ID" value="MST35354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10060" checksum="E9FC847ACFDAD198" modified="2021-04-07" version="1">GAMGTFADDLELGRLGPAARRAVRALGTAGTVARGAVVVIVGGFLLAAGIDHRAGQAKGLDASLVAVGRHPYGVAVLVAVAFGLACFGLFSIVAARYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMI8</accession>
    <name>A0A7K0JMI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000014">
        <property type="protein sequence ID" value="MST31176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="488" mass="51789" checksum="4690D0C8AD922B72" modified="2021-04-07" version="1">AGRPDALPTDGRPTTGQPGDDGSADGGFLRFDDLEPAAEVAAAPLEPEVAGPVDPSERAEWASRLATIRAPQTATPPRRAPHRGRRRVLTAAVAALHAAWLLRQAGHDVAVYEARARVGGRVWSQRLDNGVWIERGAEFIFPSEHVILGLCARLRLPVTPHGVLFFRRADQEGRVPGVEHVLDVQERLAAASLAERARERPLSMADLFETALGPGFGDDPVFLRQATSMTSDPRLASAAGEALGDAGDRDGYLDHTYRVVGGNQQIALRMAADLAGCLRLETPVRAVHQARDAVELTLHDGSCVAGDAAVVAVPFPLLGEVERNFAWPGPIERALTGLVMGGAVKASVPLRTGSAPRGVQVPDRWWAWNSLSPGGDGSGAAATAFASTAPDLPPGRGGDAPWARMIQELRPDLDVAGDALVTDWAREPWTRGSYTVRGLSWRPEDDGAFNAPVGRVVLAGEHTGTNGDMEGALWSGQRAARLLSACYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMM9</accession>
    <name>A0A7K0JMM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome subunit alpha</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prcA</name>
        <name evidence="4" type="ORF">GHK86_00485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000018">
        <property type="protein sequence ID" value="MST31208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="27481" checksum="C915818836A3ECFE" modified="2021-04-07" version="1" fragment="single">MSMPWYVAPEQFMKDKADFARKNIARGRPLVAVVYDDGILICAENQSTSLHKVSEIYDRIAFAGVGRYNEFDQLRRSGVQHADIKGYQFSREDVDARSLANLYAQYMGNVFTHEMKPLEVEILVAEVGDRPGRDQLFHILYDGSVVDEDRSTVLGGEADAIAGRLDGSFRAGWGLAEALVGATRALEGPDRSVNPKDLEVAVLQRSNGRRAFRRLDQAEVQRLLTEGGAPGGEPDVNLPGGTAGGSAGGLPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMR5</accession>
    <name>A0A7K0JMR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="24940" checksum="959ACAC397606DC5" modified="2021-04-07" version="1">MAPAYDRRSRLPPLRGPRQRPRRRRHRLARPLLPRRCPRHPSGQPGLPRPPQPWSPQERLHFDEVDRWNAEEGGYAHQHATKPATLAAALLDSPVGLAAWIGEKIAAWSSQHTSGEPDFDRDLLLGTLTLYWTTRTIGTSLLPYWAYRHHPNTALPADDPPPVPTAVTVFGGEAIPFPKPPRQLAERYFTVTAWAEHDTGGHFPAIAAPHLLAPTLRSFFTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMR9</accession>
    <name>A0A7K0JMR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="6" type="ORF">GHK86_00570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000021">
        <property type="protein sequence ID" value="MST31225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="375" mass="41706" checksum="F8AE5C15E7DD084A" modified="2021-04-07" version="1">MADWHEELRRVRKRLDEAAGYLDLPRLRRRRAELEVEVARPDLWDDTANGQRVSREYGQVNGDVELLDALGAKLSDVETLLELAGEAAPDELAGLEVEAGELLADVGAELDRLELRSLFTGEHDESDAVCEIHAKDGGTDAQDWAEMMLRMYQRWADRRGFGFELDEVSPGQEAGILSATFIVRGRYANGLLASERGVHRLVRISPFDAQARRQTSFATFSAVPFMEDVAEVEIEEKDLRIDTYRSQGAGGQHVNVTDSAVRLTHLPTGVVVAVQNERSQFQNKAKAMQILAARLAERAREERAAEMEALAGPKKMVGWGSQIRSYVLAPYQQVKDLRTEFETGNVSAVLDGDLDAFMESYLRWRRAGGGADAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMT4</accession>
    <name>A0A7K0JMT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_00800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000027">
        <property type="protein sequence ID" value="MST31270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_7" evidence="6">
        <location>
            <begin position="88"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="289" mass="32539" checksum="A505003F58935CC7" modified="2021-04-07" version="1">VAWAGGVDGVGIPAPPALDAAIPTPGEAAAERRLEAFLRHELDRYGDARDDPGADATSRLSPYLHWGCLHPRTLLAPLDARRRGHATWRNELCWREFYADVLWHEPGSARRSLQAPMAAMRVDEGPEADERFAAWCEGRTGYPIVDAGMRQLRAEAWMHNRVRMITASFLVKDLHLDWGRGARWFMRHLVDGDLASNQHGWQWVAGTGTDAAPYFRVFNPVLQGRKFDPTGAYVRRWVPELAGVPDAHVHAPWELRQRPLGAGDYPDPIVDHHAERDEALARYAEVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW6</accession>
    <name>A0A7K0JMW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000035">
        <property type="protein sequence ID" value="MST31310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OG-FeII_Oxy_3" evidence="2">
        <location>
            <begin position="124"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="777" mass="83703" checksum="72C04F097A28F8B9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMY1</accession>
    <name>A0A7K0JMY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lysS</name>
        <name evidence="9" type="ORF">GHK86_00940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000033">
        <property type="protein sequence ID" value="MST31298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="152"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="473" mass="52806" checksum="87858875841A8A3D" modified="2021-04-07" version="1">MSDDDLPEIPYRYERTASAAELHAAHGELPPLAETGKVVSVAGRLMARRDQGRIAFGTLRDSSGSIQLFAGAKWTDDFDGFVALNRGDWIGATGEVVATRTGELSVKVDHWVLLAKARRSFGDKWHGISDPDVRYRQRYADLWANEGTREAFLVRSRMIALTRRWLEDRGYVEVETPVLHVLPGGAAAKPFTTHHNALDMELYLRIALELHLKRLIVGGIERVFEIGRVFRNEGLSPRHNPEFTMLELYQAYADYTDIMELVEQLVAYLATELLGTTTLSYAGRTLELAPPWRRATLLELVAEHAGVELDLAMPLDELRRVAAAHDVPAEASWGPGKLVLEIYEKTTEAALWGPVFVMDYPKEVSPLARDHRSSPGMVERFEAIVAGRELCNAFSELNDPDEQRRTFEDQARAKAAGDEEAMPVDDDYVRALEYGLPPTGGLGIGMDRLAMLLTGVETIRDVILFPTLRPEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN79</accession>
    <name>A0A7K0JN79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000052">
        <property type="protein sequence ID" value="MST31378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="2"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="474" mass="52045" checksum="4A992B51B23727F5" modified="2021-04-07" version="1">ATRLSTAFDSVTLYGQDPDARPDIYGKVGNAGVSVATLEDMKALYAGFDLLAPTTSVSMTINGPAPTILAMFLVTATDQAVERFHAEHGRPPTPEEEAELRADALRRVRGTVQADILKEDQGQNTCILSTDFSLKLMGDVQEWFTAHDVRRFYSASISGYHIAEAGANPITQLAFTLANGFTFVEAYLARGMAVDDFAPNLSFFFSNGMDPEYTVIGRVARRIWAVAMKERYGAAPRSQRLKYHIQTSGRSLHAQEMAFNDIRTTLQALCAIYDNANSLHTNAYDEAVTTPTAASVRRAMAIQMIINKEWGLAGNENPLQGSFVVEELTDLVERAVLDELDRLSERGGVLGAMETGYQRGRIQDESMLYEARKHDGSLPIVGVNTFRHPDGEPSEEGIPLARSTEEEKQSQLARLAAWKQRHAAERPAALARLRDAALAGDNVFAVLMDAVRVCSLGEITACLFEVGGRYRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN87</accession>
    <name>A0A7K0JN87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF433 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000042">
        <property type="protein sequence ID" value="MST31347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="8238" checksum="0881DC9A4D2FCB8D" modified="2021-04-07" version="1">MSFDRISVDPDQMGGMPCIRGMRIPVATVVGMVADGMETSEILASFPDLEREDISQALRYAAEAVAERELPLRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE3</accession>
    <name>A0A7K0JNE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="13593" checksum="6CCBDA39FD066B46" modified="2021-04-07" version="1" fragment="single">MSAARRFSPDLAGRLAGAGLLAATGATHLELYLSGYRTIPTIGPLFLLQVVSAFLLAVAVAATTSWAVAAVAAGFAITTLGGYLLSMSVGLFGFEEVPTAAGAVAGVLDLTAFGVLAAVAVARAAAALRRRRGDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH7</accession>
    <name>A0A7K0JNH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="446" mass="47508" checksum="FDC06DFAB2949193" modified="2021-04-07" version="1">MEEPSARGIAAAVGRLVNQCKIKPGDRLPTVRSVAVGLRVSPTTVSHAWRSLARAGLVTTRGRSGTFVRGEVHASPAARMLRVFGNPAGLSLDLSSGIPDAALLPDWGPSLARAGEQRFASHYGDVPVLPALEEILRDRWPFRPERLTVLDGALDALDRVAAITVQFGDRVLVENPCFPPMLDILQERGAQPVPVELDDDGPSPEAVRRALDANPTVFLLQPRAHNPAGVSLSDVRARQLAEVLAGTSVVVVEDDHAGDISSAPLVSLGRHLPGQVVHIRSFAKSHGPDLRLAAVGGPSWAIDAIDQRRLLGPGWSSRLLQAVLVDLLTDAAPTAEVRAARDVYARRRRRVVDLLAERGVHTTGQDGINLWVAVSHEQSALVVLAADGIGAAPGAPFEVAPLRDDHLRVTVGLVPEEDAARVADALALAANPSGRPPLADRRRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX4</accession>
    <name>A0A7K0JNX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="355" mass="36884" checksum="C0886945125EE2A0" modified="2021-04-07" version="1">MGHPGPLRRAASQGPADRHLLAGRPCRHRPAVPAHRPRPPGAHPRGRGGGGVSASANGRPEVTVGLCQWLASPGRPEVNLAAAAELVAAAAGRGAEVVVLPELWASGYDAGTLAADAARAAEPLGGPRTQILGELARQHHVHLFAGTVPEAADRALYNTALLFDPQGELIAAHRKAHLYPFTGEDAIFGAGDRLTVVDTDVLGRVGLTVCFDGDFPEVPVALNRRGAGTVVQPCAYEAEASDWWDRLYPAAAVANGQWWILANQCGTTATGTLLGASRVIDPAGRVVAEARRVGPGGQADPEVLLASVDTRPRPKGETAGVAALRRCRRPELYAEEAVADRQGEPATVSAGGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY0</accession>
    <name>A0A7K0JNY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS256 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000103">
        <property type="protein sequence ID" value="MST31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="49" mass="5166" checksum="B398BF56230F64BC" modified="2021-04-07" version="1" fragment="single">MLRVVADEQAGAELASGLDEIVREGARRMLAAALEAEVDAYVAAFADET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP36</accession>
    <name>A0A7K0JP36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SCO1664 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022292">
        <property type="entry name" value="CHP03843"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03843">
        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="24726" checksum="F38388CBF0D7A820" modified="2021-04-07" version="1">MPWSSNGTFLCSVGEAVDDAGTPQLAAIYKPLRAERPLWDFPGGLYRREVAAYELAAQLGWQLVPETVEREDAPLGVGSLQRFVPADFEQHYFTLLEDSRHHASLRRMAAFDALANNADRKGGHCLLDAEGRIWGIDHGLCFHAEPKLRTVIWDWAGERIDDALLDDVARLVDAGPSDALARWLDAEELDALVHRAERLLRRRRLPQPQSDRPYPWPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP40</accession>
    <name>A0A7K0JP40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000125">
        <property type="protein sequence ID" value="MST31726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="86" mass="9497" checksum="763D7947094C7C10" modified="2021-04-07" version="1">MRAVERYGKDGPVDEQLAALSEGAEEARVRSLVSETPLAHREHLEAKRHVDALERARRSLQSTVDGLRAAQDELLDRLLADDAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP77</accession>
    <name>A0A7K0JP77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000119">
        <property type="protein sequence ID" value="MST31697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4118" evidence="5">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="283" mass="29379" checksum="3B70FA94AC322037" modified="2021-04-07" version="1" fragment="single">MKRTAAGTVAALATMAALTAVMIPIRSHLSIATTALVLVIPVVVGVVAGGFLAGILSVAAGFLVYDFFFIPPYLTLWVGAPQNWTALGVYGAVMLLVSRVVAGLNSAKAEARRQGREIEELFGLSHLLVEDKPLDILLSVLVATVSEVFDADQVALLLPGAAGLEVVASAGPPLSAAQLRRILPAAGQLVSFNPGPVQSDGLLVVALAAAARPVGLLVLSADAAAQYGRKPLLLFANHIALAVERTQLRDQALQSRLAEEVAQLAKTLVGAVSHDLRAPLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPD1</accession>
    <name>A0A7K0JPD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="747" mass="82377" checksum="010319A26DBAF069" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF8</accession>
    <name>A0A7K0JPF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000142">
        <property type="protein sequence ID" value="MST31813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8561" checksum="B77D8F4254B13345" modified="2021-04-07" version="1" fragment="single">MTEEQVAFVVDEDHPGTSEAAWAGSDRLRELAALDLPEVARVLVVAPHPDDEVLGAGGLLQVLRGRGVAIEVCAVTDGERGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL9</accession>
    <name>A0A7K0JPL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017832">
        <property type="entry name" value="Glyco_trans_2_hopen-assoc_HpnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03469">
        <property type="entry name" value="HpnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="383" mass="41112" checksum="8397C3C44A510795" modified="2021-04-07" version="1">MRIARWTAWSVSAVWACLAAAPGRFWTTAVRLPAAGPPASWPPVAVVVPARDEAAMLARTVPALCRQDYPGPTRVIVVDDESSDGTGRAASAAAAGGPVALEVLRGSPRPEGWAGKLWALHQGVSHLAGSPVPPEWVLLTDADIEHPPDSLRRLVAAATADDRDAVSLMARLRVDTGWERLVVPAFVYFFAQLYPFRLVARQGRTAAAAGGCILVRRAALERAGGIAAIRDAVIDDVALARALKRSGARIWLGLADEVRSVRPYPRLADLWRMVARSAFTQLRYSPVLLGFTLVGLVLVYLGPPIALVVGVVRVDRSLAAAGASAWAVMAATYLPMTRYHRLHPLRALTLPAAAALYAAMTADSARRHWAGGGVEWKGRRYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPN5</accession>
    <name>A0A7K0JPN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_03835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000155">
        <property type="protein sequence ID" value="MST31857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="71"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="291" mass="31301" checksum="4B55B08770183F52" modified="2021-04-07" version="1">MSVDVETRAWPAPADRVRRRPDPLATATGWLAQRHSLPAETALLVVLYAAYDLGRGAVVSGVGAAVAHAHDLYWVERRLHLAIERPVQHASMAVPGLTVTFGITYMALHLLLTGVVLLWLHRRHPEGYVLLRTALVVCSVAALVGFIVWPTAPPRLAGIGVAGTLSQAGVALNSPTLTVLFNPYAAFPSLHEAYAALTGWAIRRQARNRVLWLVGGVVMPIWVAVEVIATGNHFVIDVVAGVLTAELGRVVAVRLSRRAAQRNPAKRSSSGTAAPLRSDARTNHSRPKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW1</accession>
    <name>A0A7K0JPW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta_toxin" evidence="3">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="20882" checksum="8D84941BE633E0A8" modified="2021-04-07" version="1">MADPVLHLLAGPNGSGKSTLYERVVGPVTHLRFVNADQLAAERWPDDAEARAYEAAALAADAREELLARRESFVTETVFSHPSKLSLVSDARAAGYIVALHVVVVSLELSVARVADRVARGGHSVPEMKVRERYARLWPLVASAVRQADRATVYDNSRAAVPFRVVAEFYNGAPLAAPTWPTWVPAELQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW6</accession>
    <name>A0A7K0JPW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000192">
        <property type="protein sequence ID" value="MST31998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="10265" checksum="D979D8F63EF952C9" modified="2021-04-07" version="1">MIRSASDGAGGAGGPGTRLLRPADARIVAVGAPGTGSSAPGPGTRRQLGKVSGGSDARESGSGAGGGYADLASPATAPFGGIVGRAAQRRTPCLAMWLTHNLERPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ08</accession>
    <name>A0A7K0JQ08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14428" checksum="37C03F21E1821D33" modified="2021-04-07" version="1">MAEGATRWEDAYRSWEQAVDVRGRVVARMERKLLVATGGLSVARFEAVCRRRSVRSVAEAQRKASAIRTRLVVDGVVAERDRAVAAADAAVLVARIVLAEASKVLLCYGTAGPRLVGRSRAELRRLARLPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF1</accession>
    <name>A0A7K0JQF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proton-conducting membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="18229" checksum="89E203844CD874B7" modified="2021-04-07" version="1">MAAPKSDDRQKTMAMVCWSSDLDRVWPTLILATTGAASGLDVSIFFTFWGLRVLQKNEKRLTGTNLMQKGESLMDRGGTDHLKLGKLHFGGAGTRMIKKLADDYHVASPTELLSMAQDLGVRLYPCQMTMDLYGFEKDDFIGGLEPPMGAASFINMAADADISLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF7</accession>
    <name>A0A7K0JQF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_05495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000234">
        <property type="protein sequence ID" value="MST32180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="379" mass="40012" checksum="7EBBC951D0DF96E3" modified="2021-04-07" version="1">MVGRPSGSITLADIANVAGVSPGTASRALNGRGGVNAETRERVQEAARRLGYQPNALARGLLSGRSYTVGLITTDSFGRFSIPIMLGAEDALGAGQMSVLLCDGRDDPIRERHYLQTLLERRVDGIIVTGRRTDPRPPIGTDLGVPVVYAMTQSTSPEDLSITPDDLQGGALAVGHLTGTGRRHVAHVTGPERFQAARLRAQGALTQLEADGGSLVGGQVFYGEWTEQWGRQAAAMLLDLVSRGAELDAVFCGNDQIARGMLDILREAGVAVPDDVAVMGFDNWEIIAAASRPPLTTVDMDLREVGRVAAESLLAAIGGNRDRGVRTNPCRLVIRDSTGPGRGIRSSATGTGRPHADRSPASSSLIDRSGPKASQRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL0</accession>
    <name>A0A7K0JQL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000235">
        <property type="protein sequence ID" value="MST32187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="207" mass="21739" checksum="0C55690FA2BE2D7B" modified="2021-04-07" version="1">MRVDRVVTAGVFSLDGQDFDVENNVWVVGDAERVVVIDAAHDAAAIADAVGGRRVLMIVATHGHNDHIDAAAELADRVHAPVAIHPDDRMLWDAVHPDRSPDLALADGQVIDAGVAHLAVLHTPGHSPGGVCLHLAGEGVLFSGDTLFAGGPGATGRSYSDFPTIIESIRTRLLTLPPDTVVHTGHGDDTTIGEEAPHLGEWIARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ8</accession>
    <name>A0A7K0JQQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="6" type="ORF">GHK86_05885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000257">
        <property type="protein sequence ID" value="MST32253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="162"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="309" mass="31782" checksum="4454003D94BE6BC6" modified="2021-04-07" version="1">MGARVVAGTANRRLACAVTAALGTEPAVSETARFPDGELRPVVAELRGEDVYVVQPTGPPVNEHLVELLLLLDACRRAGAARVTAVVPYFGYARQDRRGKAGEAVGARVVADALAAVGADRLLVVDPHTIALEAVCSMPVEMLTAVPMVAAGLQPALPDAAVLVAPDLGAVKLAERYSSILQRPVAVVRKTRVSGEVVRAHQLVGDVSGRPVVIVDDMISTGSTIEVAAAVLRAHGAAAAPTAAATHGPLVRGAVERMAGAGVARCLVTDTAAGEDRGSVEVCSVAGLLADAIDRLHRDRALDDLLLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU5</accession>
    <name>A0A7K0JQU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7128" checksum="AB041865D4BC7249" modified="2021-04-07" version="1">MNGTDHPRSKPSDTTVGALLRGTTGRRVEQLAQRISAALPSIEEALTGGSLVVIEPSLIRIRPLPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR73</accession>
    <name>A0A7K0JR73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1360 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000290">
        <property type="protein sequence ID" value="MST32435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010773">
        <property type="entry name" value="Mycophage_PG1_Gp7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07098">
        <property type="entry name" value="DUF1360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="13735" checksum="4BE18DF27A023B5D" modified="2021-04-07" version="1">MGAFVVRRRTLPERLPVEDLALLTVATFRLSRLVTKDSVTAVVRAPFTRYEEPAGEGEVNEEVTGSGLRHAVGELVSCPFCISVWAATGLTFGLVAAPRSTRLVCSALAAVTGSDALQFVFAALRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR96</accession>
    <name>A0A7K0JR96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000303">
        <property type="protein sequence ID" value="MST32468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="17220" checksum="A113FC620A526C04" modified="2021-04-07" version="1">MGANRRTTSHHEFMGEAGHLIDDLVRDVEHGRFERSLSGLTAVAAAVTTAEVYFEHYRASFGNKWMWTPIIVTPPVMVAGVAGVFSRRWAKTALPLTALVYTANGLLGEFFHARGVARRPGGWGLASYNVPMGPPIMAPGLMTLVGGMGILAALLRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA5</accession>
    <name>A0A7K0JRA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029606022" evidence="3">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="233" mass="23337" checksum="A574CE62CF3A6C5F" modified="2021-04-07" version="1">MSASVAVAVTAGLVWALATHPVVVVLAPSRRAAAVRAPAPAPASTAPGTARPSGPRRAARAGLVGTPPPSALEQGVTSSAPVPTAPPVALSIPAIGVHAHVVAESLGEGRSLVIPPPAEVGWYAAGPAPGQEGTTLVAGHIDDNGVVGAFLRLSAAQLGDRVALTTATGRRYVYRVAARRLVPQADFATRHLVSASGPPRLLLVSCGGAYDPATHLYQDNVVITASQVSPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE3</accession>
    <name>A0A7K0JRE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000226">
        <property type="protein sequence ID" value="MST32159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="26338" checksum="E869B039EED20062" modified="2021-04-07" version="1">MQSDSSASLGGLPAGRLPLARVVRRSAADEVQGQLAALIESGELGVNERLPSEAELSRQFGVSRPIVREALGRLQALGLTEARTGRGTFVASAVTRLTLCFGQYSAADLNEVRRAVEVPAARLAALRHTDEDLEVLASTLDSHEGATTAEETVATDAKFHCAIAHATGNKLFVRLVEDLREILQEQSLAVSSLRTRGPHAAREHRRVLVAIADGDGNAAAAAMNDHLDAVERAIGELGRKEREPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRF8</accession>
    <name>A0A7K0JRF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ChrB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000312">
        <property type="protein sequence ID" value="MST32493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="21077" checksum="F8B434BEC5880060" modified="2021-04-07" version="1">MADAGDPRPPTAERAGRVPWLLLVYRIPSEPSRLRAGVWRRLKGLGAIYVQSSAAALPSSPTAERALRTLRNEIVEMGGAAFLLASDVLAGEPDLVALFNAARNDEYEEIVDRCEDFLRQVGKEYDADHFTYAELEENDVDLAKLKGWFAKVQARDVLGAEGVGRAEEALERCEQALEAYAVHVYDREVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH4</accession>
    <name>A0A7K0JRH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2087 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000323">
        <property type="protein sequence ID" value="MST32532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2087" evidence="1">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="11617" checksum="EE2258C32412E61F" modified="2021-04-07" version="1">MREVLQPEDLGATPAQAAVLRGFVVDGRLQRMPAQHSKRLVVLDFLAQRFEPGVRYREAEVNDRLLAFHSDFATLRRALVDEGFLERRDGAYWRAGGTFEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI1</accession>
    <name>A0A7K0JRI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000325">
        <property type="protein sequence ID" value="MST32541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="117" mass="12047" checksum="5C6B5E10D9D04C97" modified="2021-04-07" version="1">MTSPTQGIKTVLHPVSDLAAAKAVYTALLGTAPQADSPYYVGFEAGGQHIGLVPRGGPQDMTSPVAYWHVSDIEAKLAEVTAAGATVREPAHDVGGGRLVATVTDPDGNILGLLQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS12</accession>
    <name>A0A7K0JS12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000373">
        <property type="protein sequence ID" value="MST32736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10636" checksum="68B51002B4CF85E9" modified="2021-04-07" version="1">MLPVAFISEVFFPAPAEPTWLRQLAAALPVQPFVAGMQAAFSASGSRLGGHGLFVLGCWSIGAVLLALAISRWEPDTLRRQRGARSHTHTARRGVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS72</accession>
    <name>A0A7K0JS72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_08660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000390">
        <property type="protein sequence ID" value="MST32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="473" mass="49439" checksum="34624D5E67CE2D91" modified="2021-04-07" version="1">MELNGINIIRERERKGRPRQLFWPWFGANVSVLGISYGAFVLGFGISFWQAVVVGLVGIVVSFLLCGLVAIAGKRGSAPTMVLSRAAFGVRGNRLPAVVSWLLNVGWETALTTLATLATAEVFKRLGAGGGTGTEVIALVVVAALIVGGGVMGFDTIMRMQVWITLVTGVLTVVFIALSAGHVHWHQVAAVHAGSTQAVIGALVFVMTGFGLGWVNTAADYSRYLPRRSSTPGVVWWTTFGSSLAPIALLVYGLLLAGSSASLSKAIGGDPVGALAALLPTWFLVPFALVAVLGIVGGAVLDIYSSGLALLTAGFRIPRYLAAGIDGVLMIAGTIYVVFFASSNFLGQFEGLLITLGVPIAAWCGVFLADLALRRHPYVEDDLFRPDGRYGNVRLLPVLTVVVASVLGWGLVTNTAASWLTWQGYLLSPLGLGGKAGAWAYANLGVLVALALGFLVTLTASAGAVRAQEAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS97</accession>
    <name>A0A7K0JS97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tsaE</name>
        <name evidence="7" type="ORF">GHK86_08690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000392">
        <property type="protein sequence ID" value="MST32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="21266" checksum="C6293AC1C6716795" modified="2021-04-07" version="1" fragment="single">MGAGRRRARPHLPPRCGAAGRRRGPGPDAGRLRAGQADPRRRRHRAVSTSPAPVVAVQVADLAGTAAVAAVVARLLRAGDLVLLTGDLGAGKTAFTQALAGELGVHEPVTSPTFTLVRQYPTDHGLVLLHADIYRLEQLAEVIDLGLPEQLEEGCAAVVEWGERGAPALVPEYLSVTLTAGAPDRETARLVELRPVGEPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE6</accession>
    <name>A0A7K0JSE6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000310">
        <property type="protein sequence ID" value="MST32489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="17041" checksum="81516EDB9ECA82C3" modified="2021-04-07" version="1">GPLAAGTRLTAGDLGTAELRLPAAVAATSYPQAAALVGRVLAVPLRPGELLSAPELTPTGGQPPLRPVTVTVPGPDLLGLVPAERVDVFLTTSTGSTARTALLLRGAEVIRVATPSGGLLGGGGGSGSDVLVLGVPSLGEVESLVAAGHAGSLDVTVAEPSDGVGPGPGTGGTGGSGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE7</accession>
    <name>A0A7K0JSE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000406">
        <property type="protein sequence ID" value="MST32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02929">
        <property type="entry name" value="TMADH_HD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037348">
        <property type="entry name" value="TMADH/HD_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="10"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="396"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="734" mass="81905" checksum="BA9969E6FA1C4F77" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU4</accession>
    <name>A0A7K0JSU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000458">
        <property type="protein sequence ID" value="MST33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="174" mass="19006" checksum="1F3C05C47616CCA9" modified="2021-04-07" version="1" fragment="single">MPDAAPFDLAVTDRLLATTRSVRKRLDLDRPVEREVILDCLRLAQQAPTASNSQGWRWMVVTDAALRARLAELYREASADYFAADRTGGDGQATRVRDSAVYLRDVLDRVPVHVIPCVRGRAGGLPNAQAAGLYGSIIPAAWSLMLALRSRGLGSAWTTLHLGREREAAELLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT17</accession>
    <name>A0A7K0JT17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_10205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000480">
        <property type="protein sequence ID" value="MST33091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="10993" checksum="FCBAD7563E6BCAC9" modified="2021-04-07" version="1" fragment="single">MDVAAPVAAAGRPDLVATLGRWGEGARRDLGWRRTRDPWAVLVAEVMLQQTQVARVEPVWSRFLDRFPDPASCAAGGVAEVVAAWAGLGYNRRAVSLHRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT70</accession>
    <name>A0A7K0JT70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000489">
        <property type="protein sequence ID" value="MST33113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="18893" checksum="EBA8B494C677E50A" modified="2021-04-07" version="1">MTRTRRPTVHLLCGYAASGKTTVARRLSADIGAVRFTLDEWMLSLYDWVPDDPEYGPAAERAKELIWSVASQCLGLGLDVVLDWSQWSRERRKAWSSRATDASANVVIHYLEVPLDEALRRLAARNLERPPGTHQLGIDEARSFFEEYFEPPHINEGLELVIERVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH1</accession>
    <name>A0A7K0JTH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000529">
        <property type="protein sequence ID" value="MST33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="289" mass="29178" checksum="1A00D7BA9163E6E0" modified="2021-04-07" version="1" fragment="single">VPPAPAGDLQVEPAVRAGRHRARYVVTCHNAGNVPLDLALSATDPERSFAVTFAPSVLSVEPGRTGRTELQVQRRRRLRGGETSHQITVAGTSADLQLDTKAVFRHKPLMPTGVRTALVLATLVAGWAAIILVALHFALAKNPLAVEAPASFYASASPAALHAAEHSALGGINFDLASANGSTPKGAVPKTGIVVGVGGTISGTVDARSTGAGVGDITVQAVQGGQVVASAATAADGSYSVDGLMPGAYLLELSAPGYPSLWYGGRSGAGVARGRAVPVQVDAQATTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM5</accession>
    <name>A0A7K0JTM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000418">
        <property type="protein sequence ID" value="MST32879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000470">
        <property type="entry name" value="CbxX/CfqX_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00820">
        <property type="entry name" value="CBXXCFQX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="15612" checksum="2D267609F290CA62" modified="2021-04-07" version="1" fragment="single">MARTPPGDPAGGSTDAEGEEAALSPPLPPDAVVDPGEERRASNVDAILGRLDAELIGLEPVKTRIQEIAALLLVDRMRRRFGLVGQRPTLHMCFTGSPGTGKTTVAVRMAELLHGLGYLTRGHLVAVTRDDLVGQYVGHTAPKTKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU09</accession>
    <name>A0A7K0JU09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000586">
        <property type="protein sequence ID" value="MST33420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="20973" checksum="C44835C8E8FB2E37" modified="2021-04-07" version="1" fragment="single">MVRWVLVAAVVGLAAWVVSGQLGELTGAGRLLAHLRWSWAVVAVAVEVLSYLASAQLQRVLLWSGGIPAGMGRTTLIGLATSAMQNSLPAGAAFAGVFAYRQYRRMGADEVLAAWTVVAVTGCLFVGLAGLAVVGLLLAFGTGSALGLVQVLGGLGATAAALVLLWSRRRWVLARVVGGIRLGQRLTGRPHGDVAAHAQRVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU42</accession>
    <name>A0A7K0JU42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000604">
        <property type="protein sequence ID" value="MST33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10546" checksum="E50CFE7B5E011B71" modified="2021-04-07" version="1">MLAAFSISPLGDAPDGSVGPAVAEAVRIVRASGLPNETNAMFTNVEGEWDEVMAVIKACVDRLAEVAPRVSVVVKLDVRPGVTGAMRSKVERIEEQLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU44</accession>
    <name>A0A7K0JU44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000603">
        <property type="protein sequence ID" value="MST33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="385" mass="39498" checksum="5AC5EF5157C24247" modified="2021-04-07" version="1" fragment="single">MADTWDVIVIGAGPPGENAAQYAIAGSDRTAALVEAELVGGECSYWACMPSKALLRPVEAADAARSLPGIPVGSLDVGAVLARRDSFTHDHDDGPQVQWAEGAGIAVIRGRGRLAGERTVVVTSPDGGERTLTARYAVVLATGTTASIPPVPGLRECRPWTSRDVTNLREVPRRVLVVGGGVVACEATTWLRGLGAEEVTMVEVGPRLLDRHEPFASELLAARFADLGVRVRTGSGVVSVQRPAAADTGVGRIHGGPATVELAGGDTLEVDEVVVAAGRTPSSSDLGLSSVGVDVSGSHGYLPVDEHLAVTGVPGGWLYAIGDVNGRALLTHMGKYQARIAGAVIAARAEGRPLDGTGVRDLADGAAVPAVVFTDPQVAAVGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE4</accession>
    <name>A0A7K0JUE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mycofactocin biosynthesis FMN-dependent deaminase MftD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mftD</name>
        <name evidence="7" type="ORF">GHK86_12700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000644">
        <property type="protein sequence ID" value="MST33575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023989">
        <property type="entry name" value="MftD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03966">
        <property type="entry name" value="actino_HemFlav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="34795" checksum="63571C999034CACF" modified="2021-04-07" version="1" fragment="single">MANGWFETVAEAQRRAKRRLPRGVYGALLAGSERGTTVEDNTAAFAQLGLAPRTAGLANERELATTVMGQAVSMPVLISPTGVQGVHPEAEVAVARAAASRGVAMGLSSFASKPVEEVVAANPQTFFQVYWVGTRDEMLARMDRAKRAGVVGLIATLDWSFAHGRDWGSPYIPERIDREAVRRYAPQIAARPGWAWSFARAGKLPDLTVPNMVPQSGSAAPTFFQAYGMWMQTPMPSWEDVAWLRAQWDGPFMLKGVTRVDEARRAVDAGVSAISVSNHGGNNLDGTPATIRVLPGIADAVGGEIEVLLDGGVRRGSDVAKAIALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG7</accession>
    <name>A0A7K0JUG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000652">
        <property type="protein sequence ID" value="MST33592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="49" mass="4888" checksum="7FC4023A32821C62" modified="2021-04-07" version="1" fragment="single">MISFSTLALLAAVVFGFLGAMIGRAKGRPGTGAVLGFLLGIIGLIVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG9</accession>
    <name>A0A7K0JUG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="19313" checksum="CC469DA4399DFEC4" modified="2021-04-07" version="1">MESERVASDLLRGVGTRLAHSAAVAAQAERVADLVGGVWGGVLVDAAWLHDIGYAPAVAVCGFHPLDGARWLRDRDWPDETCRLVAGHSRARTEAALRGLEDELVREFEAAPELPAAALAWADVTSLPDGGRCSLSHRLADILARYPDGPVHETTLANRAGFEADVAAVEALLASATSSEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUI3</accession>
    <name>A0A7K0JUI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YihY family inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_12900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000664">
        <property type="protein sequence ID" value="MST33615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="33887" checksum="740F9BF325BE9F37" modified="2021-04-07" version="1">MANTEGMVGAIEQAQRRHRTPAVGWATLKKFQQDRATRLAAMLAFWAFFSVFPLFLLLVSVLGYVLPPSTKSEVLHHVAALFPLLDPSTVGHISGSAWTIVVGGVSALWSGLAVMRATEFAFNSVWKIPMDQRPKQVEQIRRALSALGTIGVGLVISTAISGFVTGKDIGVNLGLAGHIAGYLVAGALDIGLFLVAFRMLTDRAVGLRDMLPGALLSGVVFWILQQLSSFIISRHLQHAQSTYGHFATVITILWWFYLQAVVTMLGAELNVVLHERLYPRSLGGRPETEADRRDAGAAFGGAPAQEDDRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN9</accession>
    <name>A0A7K0JUN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000679">
        <property type="protein sequence ID" value="MST33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="193"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="443" mass="45728" checksum="1EDA735F1375CDB3" modified="2021-04-07" version="1">MSGVDAPFPGLGEAVDPLRVMQRVVDEAVALVEGADGAAVELADAGAMTYVAAAGRLAGSVGLRLAADASLSGLAVRARSVLRCDDSETDQRVDREACRKVGVRSMICVPLIRADAAVGVLKISASEPAAFDERDVATLRRLADFVGFVIDAAASLSGAVASALSAEPLGGGGDEAAIARFVARVLVPAASRDAQARRRIRQVIDDVAFFPVFQPVVDLATGTTVGVEALTRFTPTPPRGPDCWFADAHAAGLGPELELATLRVALGHLDHLPGGLVMAVNLSPDAIAHPDLASLTGGIDLGRLTIEVTEHAAVDDYAELRRLLAPFRRSGARLAVDDTGAGFASFSHIIQLAPDIIKLDLNLTRGIDLDPVRRSLATAVVAFAADTGSSVVAEGIETEPELGVLRGLGISHGQGYLLGRPAALADLDLRSPAGASPLAHVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP0</accession>
    <name>A0A7K0JUP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">GHK86_13060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="WJHE01000671">
        <property type="protein sequence ID" value="MST33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
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    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR033128">
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    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
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    <dbReference type="InterPro" id="IPR042110">
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        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="299"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>IMP</name>
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        </ligand>
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        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
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        <location>
            <begin position="331"/>
            <end position="333"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="413"/>
            <end position="415"/>
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        <ligand>
            <name>GTP</name>
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        <source>
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        </source>
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            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="427" mass="46681" checksum="F49EF7F0B8F6FBA1" modified="2021-04-07" version="1">MPATVVVGAQWGDEGKGKLTDLLAKEMQVVVRYQGGHNAGHTIVVDGESFALQLIPSGILYPFITPVIGNGVVVDPQVLLAEMRGLEERGVDCSRLRVSGNAHLIMPYHQELDALAERRLGRNKLGTTKRGIGPTYADKAARIGLRVQDLLDPKIFRQKLDLVLKEKNQVLAKVYNRLALSADDICAHYLDEYAPLMEPLIADTVGIVHDALEAGQQVLLEGAQATFLDLDHGTYPFVTSSNPVAGGACTGAGVGPRHIDRVIGIAKAYVTRVGSGPFPTELTDERGDALVERGHEFGTNTGRRRRTGWFDAVMARQAVRLNSLSEIALTKLDVFDAFETIRVCVAYDHDGVRYEHLPYHQSVLHQAVPVYEELPGWRSDTTGATSVADLPDAARRYVERLAELAGVPIRLVGVGPGREQFVRFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT8</accession>
    <name>A0A7K0JUT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11420</name>
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        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000559">
        <property type="protein sequence ID" value="MST33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029831972" evidence="4">
        <location>
            <begin position="32"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="5">
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            <begin position="144"/>
            <end position="241"/>
        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="5">
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        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="340"/>
            <end position="441"/>
        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="442"/>
            <end position="534"/>
        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="538"/>
            <end position="645"/>
        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="646"/>
            <end position="738"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="740"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="846"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="827"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1027" mass="101507" checksum="7FD525E4B3B8178E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUW4</accession>
    <name>A0A7K0JUW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_13600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000707">
        <property type="protein sequence ID" value="MST33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="183"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="42472" checksum="3E747F975E41D3B4" modified="2021-04-07" version="1">MKVLHVITGLDAGGAEIQLAMLLERTRHEASVVSLYNAGPIAERIRAAGTPVHDLGMRSNTQVSALYDLWRLIRAGRYDVVHAHLYRSQIYARPAARLAGTPLVLTTEHSIGETHIERRPMTRRVRALYLASERFSDATIAVSDVVRERLVAWGVPDRKIVTIPNGIDVSSLAFDPAARARVRASFGIPADAFVIGTLGRLDPNKRVDLIVEAAAPLLGPGVKVFVVGRGEDHDRLVARTAALGASDHVIFAGFQADTAAMLAALDVYVAASVQETFGLSVLEALASGLPVCYTTCPALDGVSTGRARQVVGDPVALRAELQRLRDAPAPRAVPVEVFDRYGMGAVAGRTDQLYAELLAARARAGSRRAGRALQGAGGAATDLPSPTPLSPTPAPRAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV59</accession>
    <name>A0A7K0JV59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_14105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000745">
        <property type="protein sequence ID" value="MST33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="15982" checksum="E6A4C5E0E58B9DE8" modified="2021-04-07" version="1">MATTTAAPPSAAAPAEAPKKKGRTKLLIIGVVVLLVVAGGAYKFVLKKKPAANAKPVPGVIITEGQQTINLAGGHYLQVRVALQLIKGASPKLIDADNAELADTVLQVFAGQPMSRLSGAAGLAWSKAHLLAALDPQFPHTIYTVYFTQFVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV87</accession>
    <name>A0A7K0JV87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000749">
        <property type="protein sequence ID" value="MST33853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="50" mass="5408" checksum="A21C2BF0E4BE40F9" modified="2021-04-07" version="1" fragment="single">MTTASDHDAAGTLDPGEARRALQDERRRLEELLRDVLGAEELGEAEQGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA2</accession>
    <name>A0A7K0JVA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000591">
        <property type="protein sequence ID" value="MST33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="12314" checksum="05C7FB0FE466EBFF" modified="2021-04-07" version="1" fragment="single">MVAEPAGDPRTLFAVGGKRVLVTGGSRGIGRMIAHGFLAAGASVLITARKAEECHRAAAELSAVAADGATVRAVPADVTSPEGVAALVDAVEGRLDVLVNNAGATWGAPLEDYPAAAWRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB7</accession>
    <name>A0A7K0JVB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000740">
        <property type="protein sequence ID" value="MST33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="285" mass="29914" checksum="8A4FD8A7648D0947" modified="2021-04-07" version="1">MWGGLLLGFGVYVLFGVVPAAGNLVVSFTNYSGLAGSTTNFTGFSNYTAMATTERPGFVAGIEATIVFVAGVTILQTVAGLLLAHRLAGEGRTAGFLRVLVFLPIVLGVTIVGLIWILVFNPQAGPAASFLGAFGTQSAFFGSPSAAMPLVIFVQVWQNVGFATLVFIGGLRAINPEVYEAAALDGIGPWRRLRSITFPLLAPSVTVNVLLAVVGSFTTYNLIYVLTDGQNGTNTLGMLAFTSAFGSSADLGYGAAVSIALFAFTLLVALPLLAWLRHRERRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC4</accession>
    <name>A0A7K0JVC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_14465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000770">
        <property type="protein sequence ID" value="MST33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="34313" checksum="0291806A6FE526F4" modified="2021-04-07" version="1" fragment="single">MFYTVTAPPSQSAGDTGCRRGGTVCAVLALTGPGLHPVPLAALAVGAAWYANRVGRLRSRGGTWPLLRTGFFAAALVTVGVGSVAALPGFTGRAVQDLLLFLVAPPLLVLSGPLTLGLAAGGKGAAAARRAVTGRVARVVLHPVSAWVLYGTALLALYFTPEYRIGAAHPAVRLLIDLELVTVGWLFAYPLAGPDPKPRQLGAGWRIVTVMFGTIYFSILGMAMQSQRTPIAPGVTPAAMHAGGGDLWSSAELLTIAATIGILYEWLFVDLGRARRADQVNAAEDARQLALWRASRREAGLADVRARESVIVRSRPTGTERSEAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH7</accession>
    <name>A0A7K0JVH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_14585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000781">
        <property type="protein sequence ID" value="MST33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="462" mass="49654" checksum="7F7D6D315087CCED" modified="2021-04-07" version="1">MSDYPYAGRFPVQRRLPDQGRPREELLAELAAMAAEEDAFWETGKCSGTMYCGDHDHYAFLARAFERFAHVNALQRDLCPSATKFEGEIVAMALDLFHGGPGAVGLVTTGGTGSILHAVLAYREHAADRLGGRRPNVIKPETAHPAFDKACHLFGVELRRAPIDPVTTRVDLDWVADHIDDATVALIGSACNYGYGTVDPIAELGSLALERGVGLHVDGCLGGFILPFGEELGYGVAPFDFRVPGVTSISADTHKYGYAFKGTSTVLFADKALRDAQYFFLTDWSGGKYCSPGMEGSRSGGLLAATWASMVSLGRAGYRRYAAEIFSVAAAMQDAVRSHEELRVLGDPTFLFSFTSEAFDVYHVNDFLRDRGWRLNGQQYPNAVHMAVTRPQTQPGVAEAWAADLAGAVAYAREHAGSTPKSGAIYGGVAGGMTDEADAFIKAVMADLLDRQSGLPPEPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ2</accession>
    <name>A0A7K0JVJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Right-handed parallel beta-helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000769">
        <property type="protein sequence ID" value="MST33912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="86"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="449" mass="48422" checksum="9339F922A199222E" modified="2021-04-07" version="1">TLGRPHTTYWFAPGVHTLPSARYSAFRPAAGDTYLGAPGAVLDGQGLHPSAIAGTAPDVTVAYLTIEHFAPPGQEAAVNQGGQPGWSIHNVSIVDNTPGAGAMLGSHDVLSWSCLADNGQYGFQAFSTFDRSPLTGGPQDVTVDHDEIAGNDTYGWEIRDPGCGCSGGAKFWRVDGATIEDNYIHGNRWVGLWADTDNTGFRITGNYIAGNQRSGITYEISYNAVIDSNTLVRNGIVDGSQDQTWMPAIYISESGGSARVPGRYRGIFDIEGNVLIDNWGGVVLWENSNRFCGGRYDNVCTLVDPAVYTLASCRRHLPTARPGQTPDYFANCRWRTQNVLVARNSFQLSPQQVGSGCSQASKCGINGVFSEFGTVAPYRGWVVPEDISARQDNHFLDNRYRGPWLFDGLALGDFQSWHGSRGGWSTGFTAHQAGGLVFPAQDRGSSYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ5</accession>
    <name>A0A7K0JVJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="212" mass="22912" checksum="17A87ACADA609B32" modified="2021-04-07" version="1">MRRLPLFPLGTVLVPTAVLPLHIFEPRYRALMADLAGGDDQPPGDAEFGVVLITRGSEVGGGDTRAGVGTVARLLEATRLPDGRWVIAVVGTRRFRVERWLPDAPYPLAEVDELDEQPWDTDDAGLLVATERRVRRALALAAEAGEPGVPVTFELDDDPAEAAWQLAALAPVGAHDRQRLLELDAHADRLRLTGGLVEEVAQLLARRLGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK0</accession>
    <name>A0A7K0JVK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000791">
        <property type="protein sequence ID" value="MST33963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029851571" evidence="2">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="29439" checksum="E8EE028C194BA2B8" modified="2021-04-07" version="1" fragment="single">MLIVGSLFALLCGVANSAAAAIEKRESVRAPGGAGLRLLAQLVRRVWWLVAMGLSVVGWVSEAAALALAPVSVVATLRSTGRAGLVLIGHQWLGERFTKRELAGVIMLPIGGILVALSAGGNGPPERPLSNAVELEIAAAIVVLTLLLRLSRRGVVAGAAVGVLYAATGIYTKEIGDRVAREAWGAVPGLAATPGPWIMVAMSVWAISVTQRAFRRANAASVSAASTTVSGLGLIFLSALVYERRLAPLDLAVPFGIGLLLSVVGAGLLAVGSVDRDHTRPPPATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV9</accession>
    <name>A0A7K0JVV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HisKA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000841">
        <property type="protein sequence ID" value="MST34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HisKA" evidence="1">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="18650" checksum="1A5A50EF1EA24FA6" modified="2021-04-07" version="1" fragment="single">AYPVGRAGAVLAVDLSTHLSLDDGYDDFLALIAAAIGAAIAAAESYEETEQRAAALEELDRAKTSFLGNVSHEFRTPLTLLLGPLHDFAGDRRLPPEVRDGLAVAERNARRLLHLVNGLLDIARLEAGRASADFEPTDLAELTAGVASIFRSAAEAAGLAWVVDCPPLPGPVAVDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW81</accession>
    <name>A0A7K0JW81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000898">
        <property type="protein sequence ID" value="MST34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="235" mass="26078" checksum="367EFC1425F8200B" modified="2021-04-07" version="1">MHLRRGEVLGLVGDNGAGKSTFVKILCGYQRPDVGKLFVEGKQVHFRSVGDARAMGIETVYQDLALVPQLPVYKNLFLKREVVAGGRLGFLSDGKMRKLARQYLDDIKVNVPSVDAPVERLSGGQRQAIAVARATRSDVKILLLDEPLSAMGAKESALIIDLVRDLSKNRGVSIIVIDHNYAHIFELCDRINVIHQGVVSFDKRVEDTSLEELTNYMVSEYRQQIMSGRGARRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW88</accession>
    <name>A0A7K0JW88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_15950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000897">
        <property type="protein sequence ID" value="MST34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="220" mass="24198" checksum="2DCCF9C7A97A195F" modified="2021-04-07" version="1">MLVVDDERTERYLLRQYLTREGFEVAEADNGSDGLARLREGGVDLALLDVMMPGLDGMEVTRLIRQESDIPIILLTARGEEAARVAGLEVGADDYVVKPVSMPEVVARVRAQLRRANGQLVAGRSEGVLKVGDITLDVDARRCLVGDEPVELTRREFDLLAALASRPGKVLTRQQLLEAAWGTTYLSEKTVDVHLTKLRAKLGEAFRVTALRGVGYRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW91</accession>
    <name>A0A7K0JW91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsfS</name>
        <name evidence="3" type="ORF">GHK86_15925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000894">
        <property type="protein sequence ID" value="MST34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="14353" checksum="1AABB05D5B84A393" modified="2021-04-07" version="1">MSARASLDTVRTWATTAARAASEKQGRDTVVLAVGRVLAITDAFVITSGANPRQVRTIAEAVEEQVKGVGGPAPVRIEGLDDARWVLMDYGDFVVHVLLEDAREFYALERLWGDGEVWDWDDLRPAGVAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA2</accession>
    <name>A0A7K0JWA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000740">
        <property type="protein sequence ID" value="MST33834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="233" mass="23870" checksum="C89A3B4D50C9A576" modified="2021-04-07" version="1" fragment="single">MDPPGRRHRRGQPAARDPVLAHPAAADPGGGCRLGEGVTRPLVAVAAADVATGRVILDQQADVACYAASTLKLAILVALHRAAERGRLSLDQQVPVATSWPAAGGGDFALVADDDDPELASRAGEHVPVRDLAEHMITRSSNIGANVVLDLVGFEAVTVTLSALDATGCRLHHRFGDRQARAAGPANTVTAAGLAVLAAAVGGGRAATPDASREMLGVLAHQEQRDLIPAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD8</accession>
    <name>A0A7K0JWD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000921">
        <property type="protein sequence ID" value="MST34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C2" evidence="1">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="323" mass="32839" checksum="194172E7D91A040D" modified="2021-04-07" version="1">MPDGAGGWAVGESLAEARAAAGVPAGRRSGRPLTWPLELPAGDWAATLRTTWVEPGYLEPDASWCVPGGEPVSALANGGAFGGKLSSVAPAAARRLADESGRPVRVVLGREDVVRMGAKRPPVAIGVLPDGSGVARVARTPGIADAIRAAAPDLVIEEIDLAGPPTSAALRAAGWAEAALVLAAARGDRQVTVRAPDGGEATATVDVAEDGRPVRVRVTVACGDPLDAVVLRSYVVGAAHMALGWVCSEGIAVDEEGRPEDLTIRSWGILRAVDTPPIEVTIADGGGPPVNGSDAAFAAVAAATWVAQGRPPALPTMRDLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN4</accession>
    <name>A0A7K0JWN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000793">
        <property type="protein sequence ID" value="MST33969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="29748" checksum="07CF9F31841A5847" modified="2021-04-07" version="1">MREFADEADDRGDGLRRSAPSRAVFDEKRNLVEIECQLSRRPWWVYALLVVHDDRLKLAEVRVFPSVERDAYYDVRDEVYGKWLAAGSKGQPPPMPPEDFQRLNDAKRHRPSYGQWRRTAANLEHVGSGIDKTLLGRIRPSELVEVAAAKSSYLERLVPGGNAAVSDVLAAAPVHGAKSDLYYAKLAREYVALVGTGSRRPLVEMAERRGGKDAGWTRDKMRDEIRQCRNRLLLPSMGEHSGRPGLPMLTDRARDLLAEEEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT1</accession>
    <name>A0A7K0JWT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000987">
        <property type="protein sequence ID" value="MST34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7699" checksum="00642424D8D9FEC3" modified="2021-04-07" version="1" fragment="single">KPVYSQGNTVVTVNMNKGWKWSDGSPVTSADVKFFFELEAAGAKAGKYAAYVPGEMPDDIASVSYPSPYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY3</accession>
    <name>A0A7K0JWY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000830">
        <property type="protein sequence ID" value="MST34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036298-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="28570" checksum="D217FA8B63A5FB09" modified="2021-04-07" version="1">MGFFTDTSVCIGCKACEVACKEWNHVPEDGLDFTAWSYDNTKGLSADTWRHVAFIEQRKPLAGQITGVEVGKAAEGLRWLMSSDVCKHCTEAACLDVCPTGSLFRTEFGTVVVQEDICNGCGYCVPACPYGVIDQRHGDGRVWKCTLCYDRLQAGAEPACAKTCPTDSIQFGPLDELRERADARVTELRRQGVDEARLYGREPSDGVGGDGAFFLLLDEPEVYGLPPDPVVTTRDLPAMWMRCAVAVASVAVAVGGVFALGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY5</accession>
    <name>A0A7K0JWY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase</fullName>
            <ecNumber evidence="10">2.1.2.3</ecNumber>
            <ecNumber evidence="10">3.5.4.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">purH</name>
        <name evidence="10" type="ORF">GHK86_17250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="10"/>
    <dbReference type="EC" id="3.5.4.10" evidence="10"/>
    <dbReference type="EMBL" id="WJHE01001018">
        <property type="protein sequence ID" value="MST34460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="145"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="599" mass="63308" checksum="82966D01CC26B4E1" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX18</accession>
    <name>A0A7K0JX18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000998">
        <property type="protein sequence ID" value="MST34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9224" checksum="97630244BE53757F" modified="2021-04-07" version="1" fragment="single">MSDRNPTESLDAEGMPEVEDQPPGIDVETEQDGVFAPRDDRWRRAAGGDPAYPVTAAENRTVEGVAERAERETPDAGAAELDVGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX65</accession>
    <name>A0A7K0JX65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001059">
        <property type="protein sequence ID" value="MST34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="19683" checksum="18740AB675521B44" modified="2021-04-07" version="1" fragment="single">MTATPEYPEARRRAGFWFDPLCPWAWIASRWMLEVRRVRPVDVDWHVMSLAYLNEGRDLPEDYRKLLEGAWGPVRVVTAAISEHGDAVAEPLYTALGTRFHDRGRPQEPATVVEALEEVGLPASLAAAADDPAWDDAIRASHHAGMDQVGMDVGTPVISVEGVAFFGPVLSPIPRGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX98</accession>
    <name>A0A7K0JX98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jag_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001074">
        <property type="protein sequence ID" value="MST34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jag_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="11662" checksum="5DD2C7878EEDEC1E" modified="2021-04-07" version="1" fragment="single">MEWVETTGRTIEEAKEAALDELGVDEQDAEFQILEEPKLGLFGRIRSEGRVRARVRPTTPRAKEDRRDRRRRTRAASAADGAAEGVAETRPPTTNGGRTGGGGGAGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK6</accession>
    <name>A0A7K0JXK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_18440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001155">
        <property type="protein sequence ID" value="MST34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="457" mass="50143" checksum="42EA594E09DDF1C4" modified="2021-04-07" version="1">SHDVVASRAQMASTLGFHIILVCFGIAFPTVILVVHFIGLRRHDRAALLLARRWSKVLAVLVAVGAVSGTVLSFEMGLLWPGLFRVYGAAVGIPFAFEGIFFLLEAIFTAIYLYGWDRLSPWAHWWSGVPVAVSGLFGALCVVAANSWMNQPGGFVMSHGRVTAVHPLAVIFNAATTYEVPHMELAAYLVTAFGVAAPYAVGMLRHPERRTSRYHRLGLLVPSVVAAICTPLQIFVGDTIARAIEHQQPIKFASMEYVAHTHRGVTEWVGGIYYHGHIYLGLNIPYFDSILVGFSPHTKVIGWDSVPRSQRPPLPSLIHNAFDLMVGIAFLMLALAAWLAVSWWRKRDFPVTRWFAGLTALGAPAAVVALECGWIVTEVGRQPWVVYKRMTVAQAATPVPDVPWTFGAIVALYIVLTITTVVVLALMARRWNRSTEVAEHDVPYGPGRAHAAAPAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN1</accession>
    <name>A0A7K0JXN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001170">
        <property type="protein sequence ID" value="MST34713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="13293" checksum="44432979E17DDE9E" modified="2021-04-07" version="1">RRVLPGATAESTVGELRARIDAAGVDGLRYDLDVLVFGEASELPAVHPWAAQVRAAVASATGAEPATIGMSFTTDARFVRNQAGIPAVVCGPGEVAQAHTTDEFVAVGQLADAAAAFAELFATPPGFVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ8</accession>
    <name>A0A7K0JXZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001252">
        <property type="protein sequence ID" value="MST34845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="89"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="214" mass="23774" checksum="AF43809D5C0B003C" modified="2021-04-07" version="1" fragment="single">AEDLVGLRTADITHPDDQPRCLATLDQLMGGETRTDQIHKRYVRADGSIVWAVRTTTVLRDGDGAAIGLFTQVVDVTASTEMREEITRSEQRFKALVAHASDLIILLDRSGRIRYASPAAGRVLGYSPEQLEGRDALGFIHPEDQDAAEQRFDELSATAGPGAPARYRVRHHTNDWRDVEVVTTNLLDDPTVAALVLNVRDVTEQTEYQRRLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY38</accession>
    <name>A0A7K0JY38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001222">
        <property type="protein sequence ID" value="MST34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="58"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="286" mass="30983" checksum="40CF66658AB0A2DA" modified="2021-04-07" version="1">HAAYRAGRRLHEPAHHPVEVAPGVTVDAWVTLPDAGRWPAPHPLLVCLQGGGTQFGAHWSHELQLLAASGFATLYLNARGSAGYGDAWQRAVCGPRSHTPGRGWGHDDVRDVETVLDAVLAAHPDRLDRARVGVQGGSYGGLVTTWLLADSDRFAAGWAERGPYDLVGLAGTNDESPWFFEAYLGPTVVDDPAAYWAASPLRLARQITAPLCIVHSEQDLRCPVQQAEELFMALKLLDRPVELLRFPGESHGLSRTGSPVHRRQRLELLVDWFAGWLAPGGGGPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY56</accession>
    <name>A0A7K0JY56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001237">
        <property type="protein sequence ID" value="MST34822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="357" mass="40648" checksum="3116216220A88034" modified="2021-04-07" version="1">SRQPEIFSSARGIRLEDMDDEETEARRTLMEMDPPAHTRYRRLVSRAFTRKSVLAYEDAIRALARRIVDEVHGTPELDFTDLVARQLPMRMLGRLLGLPEEDSDWLVKRGDALIANSDPDFTDYVVDQVDTSAYRLLPFRSPVAVELMGYGREAFEARRRHPSEDLLSALLAPMPDGEHLSDAELANFFTLLVAAGNDTTRYSMAASMKALVERPAVREALTAEPARLERAVEEMLRWASVTMHFRRTATRDTELGGKQIRAGDKVLLWFVAANYDPEQFADPYHFDPDRHPNDHVTFGLKSPHLCLGAHLARMELRVLYEELLPRIESVSLAGPPERLRSNFIAGIKRLPLEISWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC8</accession>
    <name>A0A7K0JYC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_19785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001324">
        <property type="protein sequence ID" value="MST34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="361"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="397"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="693" mass="74962" checksum="D95203974C533536" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF8</accession>
    <name>A0A7K0JYF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001350">
        <property type="protein sequence ID" value="MST34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="197" mass="20683" checksum="B54785B68EB0D721" modified="2021-04-07" version="1">SAFGDDERSSLDAVRGVGRTAAALLHLPKPTIAKVDGVAVGAGCNLALACDLVVASDRARFSEIFARRGLSLDFAGSWLLPRLVGLQRAKQLAFFADIVDAGEAQRLGLVTEVVPAAELDAFVGRWAARLADGPAVALSLSKGLLNAATTTSLEAALEAEAVAQAHNLGGPEAREALRAFRERREPRFRDAGPQRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI2</accession>
    <name>A0A7K0JYI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1876 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001369">
        <property type="protein sequence ID" value="MST35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="18063" checksum="24C9BB9F035E3CB5" modified="2021-04-07" version="1">MHLELSEDQAVELERLAAAAVTELGQEIAISHEDQHRAQLLVRRDLLAAAREALRGERGERGGALGGGRASPSGRPDPERVWTAEVVFSEDEERTRADARMRAAQRDWHGWGRARRNPADPDVPLVGEELAAARALVDLAHQLLDAAAQRVEVFERRPVHLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL2</accession>
    <name>A0A7K0JYL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001363">
        <property type="protein sequence ID" value="MST35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="11057" checksum="82981C10DFB4E95B" modified="2021-04-07" version="1" fragment="single">TYSLHPPVDGSGIGAIETFLFSTRTGYCQQFAGSYAVLARSIGLPTRLAVGFTTGRRIGPHRYQVTDADVHTWPEVWFPRYGWVPFEPTKGVPGAGFAIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL6</accession>
    <name>A0A7K0JYL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_20285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001389">
        <property type="protein sequence ID" value="MST35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="243" mass="27044" checksum="E3168FC50E837227" modified="2021-04-07" version="1" fragment="single">AGARPRAVRALDQEADGGGAGPAADPVRLYLREIGRTPLLTGAQEVALARRVEAGLAATRRLMERADAGEDVESPEAAEDERLRLDGLAAKEVLVRANLRLVVSIAKRYRSRGMAFLDLIQEGNLGLMRAVDKFDYSRGFKFSTYATWWIRQAITRAIADQARTIRIPVHMAETINRVVWAQRQLVQELCREPTVEEVADKADMTPSRVRETMRVSLDTVSPGSRRRTPRTTPRFAPAPGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM1</accession>
    <name>A0A7K0JYM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">infB</name>
        <name evidence="12" type="ORF">GHK86_20300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001391">
        <property type="protein sequence ID" value="MST35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="133"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="7">
        <location>
            <begin position="136"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="637" mass="69072" checksum="925E99CA65DDD117" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM4</accession>
    <name>A0A7K0JYM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001384">
        <property type="protein sequence ID" value="MST35046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="14534" checksum="2307E56F68D49931" modified="2021-04-07" version="1">MSDERPWAPPGEHVAVRRHWTYAPPPWVLYEAVVGEADRWLRPLAGERAPVVAAHRRPDWILLRPWITDAVGAVELEVEPDGLGSRLTVRAYADLPVLEEESRRRVRHRLGTIFGAGLREWVDEPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS1</accession>
    <name>A0A7K0JYS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001413">
        <property type="protein sequence ID" value="MST35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="490" mass="52917" checksum="AA8818D0839A1FD1" modified="2021-04-07" version="1" fragment="single">MTERVKRAGGPARETVPLLSACLITRDEEANLGDCLAALNFVVDEVVVYDTGSTDGTVELARRLGAKVLEGYWDDDFSRARNQALAACKGTWILHVDADEVLEADARILRGALEADPPADAFTVEIYNLIGDGSRPGYTHRGVRLFRRRRCHWVGPLHEQVVLRPGHPGTVRIGAFPHGRLVHSGYLETSVVDHDKLERNLRVALAAKEQGPAEGSEAAVRALNLGRSLAAVGRFEEALEQYRVAADGLEVVVARRMACMHAAEATLELRRPEETLEWVERLRACTARPAIPDVLEAQARVLLGEADRAVALLDGVGGEAADEDGFALPGGLVETLLANALLEAGRADDAADVLLELVERIGDALTVANTVQTLGRAGRSFEVLARSLPERHLIRAAAALTMILSDDADRAAEELWGRFEGRPELLAAAVRFGPKLPPSRALVWSARLRGVGAAERCPLLERARSHPDPRERALAAATAIVAFADPAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYS4</accession>
    <name>A0A7K0JYS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001155">
        <property type="protein sequence ID" value="MST34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="388" mass="40592" checksum="EF7D46A57EC5A70A" modified="2021-04-07" version="1" fragment="single">MEPQHRGRRARRPLRARSGTRRRARPAVSAGAGTPGIDDALAAVLFVGITLYAATGGADFGGGVWDLLAVRDRRGTGPREVIDRSVTAVWEANHVWLVFILVILWTAFPGAFAAVMTTLWIPMVVALFGIVLRGAGFAYRKEVRHLRARQATGIVFASSSLITPFFFGAAVGGIAAGRVRAGFVTGLVSSWTSGFSILTGALFVAAGAFLSAVYLCTDTTAQGRLELRPYFVRRALAAGVVTGGLALGALFDLARTDARVYDHLTGRAVPLVVASGVLGIATLAQLARGRTAGTRPLAAGAVTAVVWGWGWAQYPDLLATSLPLRNGSAPTGTMDALLVVFALAVGLVLPSLGLLYYLATGQELGEELGEELGEDERDLAGAALVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW0</accession>
    <name>A0A7K0JYW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_20765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001471">
        <property type="protein sequence ID" value="MST35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="3">
        <location>
            <begin position="36"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="748" mass="78499" checksum="3C837D871C6F3A3A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY3</accession>
    <name>A0A7K0JYY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001482">
        <property type="protein sequence ID" value="MST35163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="68" mass="6668" checksum="E41B8D7B90C398DA" modified="2021-04-07" version="1" fragment="single">MTPGPHTALVVIGSALAVVGAARSTWSPCGRSMLSSINPVGEAGRGRRFGPTAAWFVTGAVAGGACLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ02</accession>
    <name>A0A7K0JZ02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_20965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001504">
        <property type="protein sequence ID" value="MST35191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="19798" checksum="15FC9C4C835F3D92" modified="2021-04-07" version="1">AGPPAATTERGARGQVDLPGFDPRPAAVLCALFDDGGDAAVVLTRRSATLRSHTGEVSFPGGRLDPGETPLDAALREAEEEIGLDPGGVEIIGTLRPLSTSSSGSLITPFVGVLPGRPRLRPNAAEVARVFTVTLAELVAPGTYHEEIWEREGGAFGVHFFEVPGETVWGATARMLRDLLDRVLPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ53</accession>
    <name>A0A7K0JZ53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001525">
        <property type="protein sequence ID" value="MST35217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12132" checksum="7B75DDF4D1160ADE" modified="2021-04-07" version="1" fragment="single">MTDTTNPLRAAGFLFDLDGVLVDSTAVVERHWRRLAASLGLDADRLLAGVHGRRSSDTIRSVTAHLPRLDVDALVADFERDEASDLDGVVALPGAAATLARLPAGRWAVVTSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ60</accession>
    <name>A0A7K0JZ60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_19275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001257">
        <property type="protein sequence ID" value="MST34854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="295"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="459" mass="49319" checksum="7E6BE4C3A0D29123" modified="2021-04-07" version="1" fragment="single">MVQTTAPAWAAGLNAEQRRAVEHDGGPLLVVAGAGTGKTRMLVSRLARLLDGGVPPERILLVTFSRRAAAELVRRAGQLADPAAARRVQAGTFHSVAHQILRRHGAALGLGEGWSVLDQGDARDLFALVRQPVAQRQGRRFPRTETVAAVYARVVSTQVPLEQTVARTFPWCSDDLEGLRAVFTAYTARKREQHLLDFEDLLLCWRAAVLDPVTGPALAAAYDHVLVDEYQDTCVVQSDILRALRAADPRITVVGDDAQAIYSFRAATVRNILDFPAHFPGTTVVTLEQNYRSTGPVLALANAVIAEAGEGHRKQLWTAEPGGVRPVLATCPDQQAQAEAVAQSILEHYEAGVALREQAVLFRSAHHSDLLEVELRRRRIPFHKFGGLRFLEAAHVRDLLALLRLPDNPWDELAWNRVLLLADGVGPAAARRIAEAIGVRGGSGGSGGSGGSGGAGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD4</accession>
    <name>A0A7K0JZD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-oxoprolinase subunit PxpA</fullName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="1" type="ORF">GHK86_21235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001547">
        <property type="protein sequence ID" value="MST35242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16718" checksum="013795D20B82CF04" modified="2021-04-07" version="1" fragment="single">MDLNADLGEGFGPWTLTDDEALLDVVTSANVACGFHAGDPVIMRRIAARAVERGVAIGAQVSYRDLAGFGRRHMEIAPEVLRDEILYQFGALQAMAEVAGGTVAYVKPHGALYNRIVHDEAQALAVAEAVAAIRPGLAVLALPGSVFARAAADAGLRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZZ8</accession>
    <name>A0A7K0JZZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001449">
        <property type="protein sequence ID" value="MST35124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="70" mass="7658" checksum="94FDDEE1565DF638" modified="2021-04-07" version="1">MAVVVTECPTCGVVRVYLGRTPLMTVDTFAPGTRRGVVIWSRPVGVREATIQIESMSWRRVAIIEGVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMW5</accession>
    <name>A0A7K0JMW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ORF">GHK86_00530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="188" mass="21083" checksum="67067369A42CF4B9" modified="2021-04-07" version="1">MDAPSRPRLKVRYDSELRAQLQRDLGLDNVMLVPRLEKIVLNSGVGRATQQQSLLEGAVRDLAAITGQKPMVTVAKKSIAGFKLREGNPIGVKVTLRGDRMWEFFDRLVSLAIPRIRDFRGLPTRGFDGRGNYTFGVTEQLIFPEIDYDKIDTTRGMDITIVTTARTNAEGRALLDAFGFPFRKEGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMX8</accession>
    <name>A0A7K0JMX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3107 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="8750" checksum="AE9FD84A686E8A56" modified="2021-04-07" version="1">MDVRIGVTQTPKEIEMDLGDGADADAVARQVEEALGSESGVLWLTDRRGRRVGVPAAKVAYVEIDARQDNRKVGFGVAIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMY3</accession>
    <name>A0A7K0JMY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmD</name>
        <name evidence="7" type="ORF">GHK86_00500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7081" checksum="43D9D0325AC88CE4" modified="2021-04-07" version="1">MADLLVTQVRSGIGTKPKHRGTLRALGLHGIGSSNTLPDRPEIRGMIARVPHLVRVEAADAASAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN89</accession>
    <name>A0A7K0JN89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000056">
        <property type="protein sequence ID" value="MST31388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="34105" checksum="8D3F05C82BD31DC9" modified="2021-04-07" version="1">MGQFLLRRTGQAIAVLFGVSIIVFVMIHLLPGGPARAMLGNRATPAKIAAFDRQYGYNRPVVVQYFRWLGNVIQGNLGFSAKLNESVTTLISQRLPGTALLVGLANLFALVLAVPIGMVQAFRRNRLVDYLATGLSFVFYSMPIFWLGLILVVLLAVQFHLFPPIVPQASLGQLITTPADIALPVITLTLVTIALFSRYIRSSTIEALTQDWVRAVRAKGFTETDLAWRHVLRNSVGPVVTLVGLTLPVVVGGAVVVESVFNYPGMGLLLWNAAQDEDYPVILGVTLVVATATVIGSLVADLLYAVIDPRVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNA7</accession>
    <name>A0A7K0JNA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_01695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="242"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="263"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="685" mass="74665" checksum="7B7AD18FDD1DED4B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNB2</accession>
    <name>A0A7K0JNB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000071">
        <property type="protein sequence ID" value="MST31462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="12931" checksum="30DB83EEB55CF410" modified="2021-04-07" version="1" fragment="single">MSPAPARVGVVGAGIVGLAVARALQSARPGSRVTVVDKEPAVARHQTGHNSGVVHAGIYYAPGSAKARLCLEGRRMLRELCERHGIAYDACGKLVVATAADELDRLAELERRGAVNGVPGLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNF8</accession>
    <name>A0A7K0JNF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000063">
        <property type="protein sequence ID" value="MST31417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="42"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21273" checksum="97460D49DA3F6896" modified="2021-04-07" version="1">MSRVIDGRAGGDGPSRPAVCSGVHRSHLAAARDVSGTWPSGHSVWAFRGLAEFHARVGRFLAQGAARGERLLLVEDDPRPGQWPSELLEREVLRLASVAEVYGSARLPDPTAQEAVFDQVLGEALADGYVGLRIAADNTSVATGGERLAAWCRWEARADRFMAAEPVTGLCAFDRVRLDAGDLRLLVGLHEVRVGPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ8</accession>
    <name>A0A7K0JNJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="345" mass="36757" checksum="E77096B29E8C966A" modified="2021-04-07" version="1">MAARWLRLQGDVGLVTAVLPPADHGIVGELPADWEPLLRGMWRIRHFEDEVRSLFLKGQLRGSTHLAQGQEAIPIGVCDVLRIGDTTTCTYRGHGEVLAMGAPLDRAFGELLGRAGGLCGGKGGSMHFADLSVGAIGSNAIVGGHLPMAVGAGLAAQHLGTGAVSVAFLGDGATNIGAFHESCNLAAVWRLPVVFVVENNHYGEYSPMAATTPIERLATRAASYGMPGFYVDGNDVTAVRETARKAVERARAGEGPTLIEADTYRQQGHSRSDPAAYRPPGELEAWLAHDPIVRLEQAALERELAGAEELASLRAAVLDDVRAARDRALSWPEPDLQARFEDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ1</accession>
    <name>A0A7K0JNQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_01875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000076">
        <property type="protein sequence ID" value="MST31481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="24157" checksum="3FAE6E8C5431383C" modified="2021-04-07" version="1" fragment="single">MSNAEPGTRTLDTIASPTLESDAPHHRRQMSMWDPELVRGALRQSLRKLDPRALAHNPVMFVVEVGSLFTTADAFRYIAEGRGGLASFTGQIAIWLWLTVLFANFSEAMAEGRGQAHANELRRTRVATQARRLTTTGVETVPGTDLEPGDVVVVTAGEVIPGDGEVIEGIASVDESAITGESAPVVRESGGDRSAVTGGTTVLSDEIKVRITAGRGESFLDRMISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNR9</accession>
    <name>A0A7K0JNR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="7014" checksum="B3FB63D34283B53F" modified="2021-04-07" version="1">MLDVDALGDYLTVVDAVDGARRMLRAYDAGQQTLGVVAWSLAELGRQVDRAADQSSAWFDERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW7</accession>
    <name>A0A7K0JNW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional o-acetylhomoserine/o-acetylserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000027">
        <property type="protein sequence ID" value="MST31269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="430" mass="45369" checksum="07451E33E805F82C" modified="2021-04-07" version="1">MSQDARGFETRQIHAGAAPDPATGARATPIYQTTSFAFRDTDHAAALFGLAEPGNIYTRIMNPTQAVFEERVANLEGGVGALATASGQAAETLAILTLTQAGGHVVASASLYGGTYTLLHYTLAKMGVEVTFIDDPDDLDAWAAAVRPETAVFYGETIGNPKGDILDIPGVARVAHEHHVPLIVDNTLASPYLCQPLAHGADIVLHSATKFIGGHGTAIGGVLVDGGSFDFGASGRHPGFTEPDPSYHGLEYWKALGPGAYIAKARVQGMRDIGMAVSPFNAFLFIQGLETLSLRMERHVANAQAVASWLERRDEVTWVAYPGLESSPWHARARELLPRGPGSILSFGIAGGAEAGRRFVEGLELHSHLANVGDVRSLVIHPATTTHSQLSGEEQAAAGVTPDLVRLSVGLETIDDILADLDAGFRAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX9</accession>
    <name>A0A7K0JNX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TraM recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000114">
        <property type="protein sequence ID" value="MST31680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="2">
        <location>
            <begin position="422"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="599" mass="62301" checksum="61EFA937D732BC81" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ1</accession>
    <name>A0A7K0JNZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000108">
        <property type="protein sequence ID" value="MST31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10612" checksum="554D6315C747389D" modified="2021-04-07" version="1" fragment="single">MTELAYTTPVVMRPELRAGPLLAEGGEGRVYELVDRPGTLYKAYRRAVVRRPLDGLIGWEQSLAGERPELARRVRAATAWPEAVVAEPGAPDGTVAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP78</accession>
    <name>A0A7K0JP78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_03430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000133">
        <property type="protein sequence ID" value="MST31780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="8">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="238"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="42751" checksum="BC0BFA9B255F99C0" modified="2021-04-07" version="1">MPPTPPSFGALGVVPELVTALEAGGIQAPFPIQAATIADGLAGRDVCGKAKTGSGKTLAFGVPLLQRLAAAGPEASTGRRRPRGLVLVPTRELAGQVAGVLDPLSGAVGLTLTACYGGTGMDAQIKALRAGTDVVVATPGRLIDLIQRGDVSLEVVEAVVIDEADRMADMGFLPQVEWLLRHLGAPHQTMLFSATLDGDVDRLVRHELADPVRHEVGSEQPTVTAMEHRFLLVHQMDKVRVLAAICRSNERVIVFSRTKRGADRVTESLRKEGVDARAIHGDLRQPVRERALQQFASGRLPVLVATDVAARGIDVDGIDVVVHFDPPEDHKAYLHRSGRTARAGREGLVVTLVLWNEQLEVERVQRRLGLRLPVTEVFSNDPRLADLRSWDPAPASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP89</accession>
    <name>A0A7K0JP89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000047">
        <property type="protein sequence ID" value="MST31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012747">
        <property type="entry name" value="MocE_2FeS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02377">
        <property type="entry name" value="MocE_fam_FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="11591" checksum="32B08D50FCA61BFC" modified="2021-04-07" version="1">MARWIEACAVDDVEREDVVAVVDGDRVYAVYRSEDDEFFATAGHCTHERAPLCEGLVMDGVIECPRHNGRFDFRTGRALGAPVLVDLATYPVAVRDGRVHVDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI1</accession>
    <name>A0A7K0JPI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acs</name>
        <name evidence="5" type="synonym">acsA</name>
        <name evidence="9" type="ORF">GHK86_03935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000161">
        <property type="protein sequence ID" value="MST31876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="93"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="533"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="389"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="413"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="656" mass="71700" checksum="74BABBD5BE142370" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM4</accession>
    <name>A0A7K0JPM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="63"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="295" mass="31906" checksum="AE47801210ED5B84" modified="2021-04-07" version="1">MDRTAAADARIPADHPFSRHLRRAAAAEATVAHRAWRPDDGPLPALYVSHGAPPLFEDGPWMTQLHDWARAIPRPRAILVVSAHWESAPTAVTSPAADTPLVYDFGGFHPMYYEMAYATPDASALAARVAAVLPSAEPLSQRPRGLDHGAWVPLKVMYPRADIPVLQLSLPSQDPERLLALGARLRALRDEGVLVVGSGFMTHGLPYVDWQHPDRVPGWSAEFDAWAAEALATGDVEELVHFATRAPGLPYAHPSVEHFTPLFVTVGAASDPTAPVTTTIDGYMVGLSKRSFQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV0</accession>
    <name>A0A7K0JPV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000100">
        <property type="protein sequence ID" value="MST31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="123"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="342" mass="36320" checksum="C512BFB4A032AA5D" modified="2021-04-07" version="1">MVAPEGPAPARPVRAGQGPWASAFSQLRRNRAALGSLVVLVLVVVVSLLAPLYAHDIAHTNAFQSNINGTTIVNGKTVPVLTPNTSGLGLGVTPIGPTWDPAHYFLGADNQGRDVMARLLYGGRTSLLIGSTSALICCAVAALVGIAAGYFRGALDWLLSRLLDLIWAFPVYLLAISLSVILLTSGLHLGPVVIGANSLMLPILIIAFIYVPYVARPIRGQVLSLREREFVQAAVGIGAPDRRILFREILPNVMPTVIVFFPLMFALNVLTESALSFLSIGVQPPNASWGTIINDGLGLLYTRPWVAMAPGIMIVITAVSLNILGDAVRDALDPRAKLRGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV1</accession>
    <name>A0A7K0JPV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="36886" checksum="9946823F68335681" modified="2021-04-07" version="1">MATVPLTALLSWAWIAAVMEVDNAVEAAGADHVGRLFKISFPMWANALRLVDDEGIAAAELGRRAGAACNLGGLERWGWVSVGGGAGRRAGYGTSRGLRADTVIAPTRAGRYARRLFPEIVGIVEQRWRDRFGAEAVDMLRDRLSIGVRAVPWSPPEVHPSDGFITHVTGGGDSPQDAPLVVLLGQRLTQRTVQEESSLPVSLPLAANLLRVVDGEQVAVVDLPARTGLSKEAIAMAVGNLSRRRLAAVNPDRTISLTAKGRTALQAYRDSALRRGDGDDLREALEDLLHDTTAIAAGLRPPEGCWRSRRPHLARTARLLADPTGNLPWQPMVLHRGGWPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW2</accession>
    <name>A0A7K0JPW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000106">
        <property type="protein sequence ID" value="MST31609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14641" checksum="FED333FA56660188" modified="2021-04-07" version="1">MNTRFVTSILLGLGGGFVVVASQAFAAGTLAWLAFGIGIGLLLVALTPAMLGERRLVGLGLDGLTAALAAWTIVASMVFSGTLVTWLSFAEGLGFVAAMLGGLVLNQVRIVTAAHRSEAMLHRETVPAHWVEEHRSTTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ1</accession>
    <name>A0A7K0JPZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000197">
        <property type="protein sequence ID" value="MST32022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="11417" checksum="33978743449E14E7" modified="2021-04-07" version="1" fragment="single">MRADRLVAIVLLLQTHGRMTAPELAGRLEVSERTVRRDLDALCVAGVPLYAQRGHGGGWTLLGGNRIDLSGLTAAEAEALFTVTAPGNVAGMGAGGTAVGAGLDAALRKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ38</accession>
    <name>A0A7K0JQ38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000113">
        <property type="protein sequence ID" value="MST31674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="444" mass="46110" checksum="2DBC5485240D3404" modified="2021-04-07" version="1">MTTHPHDTGAAGSSTAASTAASAAVDESASIQPSLIDANLAATPGEYVGSWLRRVRSGDAGNLPVVAGLVLIVLIFESQNGNFLTAANFANLLQQMPYLVLFGMAEVFVLLLGEIDLSAGFNAACGASITLILNGQLHNWPWWASMLAGFAFCAVMGLIQGLLITRLAIPSFVVTLAGLLGLEGVLLVILNQFAGKQTGGTVAMNNHILFDIENGLVTPAAGWIITIALIVVFAVYILVRDSRRRRANLVTAPLGVQLAKIVGVAVVGVAVVVICNMNRGRTVPIRGVPTVVYLLLAIVVITTFVLTRTRFGRYVYAVGGNAEAARRAGIRVNRIRVACFTLTGLMAGVTGLFYASYTQSMSTAVDGGQLVLYAVAAAVIGGTSLFGGRGKMVHAVLGGLVIATITNGMGLLNIGAAGQYMITALVLLFAAGVDAVARRGRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ63</accession>
    <name>A0A7K0JQ63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000202">
        <property type="protein sequence ID" value="MST32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030966326" evidence="2">
        <location>
            <begin position="50"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="244" mass="25021" checksum="7B7A40348BFC9CE0" modified="2021-04-07" version="1">MNEHSRRAFPMRWVGLAVTLAIGACTLMPFCRVVAGVALVLCVPGASLAAAGGPPGGRLRVNLWAAGAVVVAVSVSVNAVVALAVGVAAGFQPTRVLIVVGGVSVAAQVVGLVTDRQRPPERRGGEGLPRAAWRPWAIACVLLSGAVAVSLVSAGALRQREAVVEVAARRSGDEVVVAVGSTSCTRGQTQRLTVAIGGRTSSWRVHASCARWAQVLVGRVHAGEQVRAVAEQRDRVPATVVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC0</accession>
    <name>A0A7K0JQC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmoD/XamoD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003454">
        <property type="entry name" value="MOase_MmoB_DmpM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036889">
        <property type="entry name" value="mOase_MmoB_DmpM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02406">
        <property type="entry name" value="MmoB_DmpM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56029">
        <property type="entry name" value="SSF56029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13304" checksum="E8DD8A850CA81E94" modified="2021-04-07" version="1">MTKTDSSPFRSDPTASGMCGCTIMNNQDGYVIAALMRGKPGVTVTEFPSMIRIDAVGTLVFDFDEIGEALGYGDDEPFSQANLEEVMSTHYGRMINLDDRTVFFANPEDAADYIGFDLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC2</accession>
    <name>A0A7K0JQC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="33882" checksum="2DDA6B02C611BE45" modified="2021-04-07" version="1">MVCAALVRGSLGAHGLVGRWRRLRPPPTAAARNLATLDLGRFAFANAQDGYDLVPPSTPGGATHVYATTDGGDSWRLTPITSGTVLTLIAAPPSGFYAVTARCGTRSCDHYQLARSTTGSTHWSTTPIPATTGLDGNPIGLAVSGNEVLVNFDPPVADGEAHLLIASDGRPPFQVHLVPHLVSVAACDLSAQPGGAVWASCPTGMMVSYLRAPSPAGPYTSVWDYAGTGGGGLVPVTGKVAYRYTGIPELRPDKLPGDTLQRSTNAGRSFVDAGPWPFAHSAGTTPQFLFLNQQDGFGLGPTGGNDPTVAVFETDDAARHWSRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK7</accession>
    <name>A0A7K0JQK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000156">
        <property type="protein sequence ID" value="MST31859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="9254" checksum="00427757ED18D54C" modified="2021-04-07" version="1">MRVDGRTVGRLGSGDRLVLAMPPGRHRLEVRFLYISSGPVDVDLGDGERRELRAARAFGFGPFEVRYLTQRRSAIRVEPVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM5</accession>
    <name>A0A7K0JQM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000162">
        <property type="protein sequence ID" value="MST31879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="26516" checksum="45E2AC0FACF99449" modified="2021-04-07" version="1">RRVDTPSTYAWQITATSACSALTTVAVVGAAGEAYTMLRRSSGFRPATLVGLLATAGLSLGAWWKGDAALGLVLAMATVATMLWYLLGVSDARPLANVMATLTVVLWVGLLGAYGAMLLRAPHGRGLFFGAVATAVLADVLSYFGGRSFGRRPLAPHISPGKTVEGLLAGGLGAVLVGVLVGRFVPGWGGVGDGVALGVVVAVFAPVGDLFESLIKRDLDVKDSGRTLAGHGGLLDRFDSILLVLPATYYLAVALHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT6</accession>
    <name>A0A7K0JQT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="8080" checksum="AF4BB0A0585AD062" modified="2021-04-07" version="1">MLSAETKWEIFLQITSGEITQADAARKWSVDVSTIIGIRRTVKDAALAALAAKPAGRPRSGTGRWSRPARRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR46</accession>
    <name>A0A7K0JR46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_04950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000205">
        <property type="protein sequence ID" value="MST32074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="386" mass="42076" checksum="1F4492FB81938E33" modified="2021-04-07" version="1">MSSLPTDVYPLTDEQVAIVELCRDFAEREIRPRARAVDEADTETPWDLWFRAAEAGITAFMLPEEYGGGGCTDVFTQCLVQEELCYGDLGIGNLLCSGGFFADPILELGTPEQKQRWLTPLCGPRPPMTALATTEPDAGSDAAAIRTTATRDGDGYLLNGSKAWISNAGEADLYVVFAKTDPDARSRGVTAFLLEKDTAGLSFGQPMRKMGQRAIVCRELFLDDVFVAEDQRLGDEGKGFIGLMRTFDISRVVLGAAAVGIARAALDYAVEYATQRKTFGAPILQHQAVAFRLADMATRVETARLLVWRAARRLDAGEQATSLAAMAKLTASETAVFCTWAALQTLGGWGYSREHPVEQWLRDAKLEEIEEGTSDIMRLVIARGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR49</accession>
    <name>A0A7K0JR49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">GHK86_06590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000283">
        <property type="protein sequence ID" value="MST32387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="32312" checksum="242402A7CFAE9828" modified="2021-04-07" version="1">MRQPRPRPAGDGRPAADRPVAVTAEAAAPPDAATRAAVLVEALPYIREFRGRIVVVKYGGNAIAGADPARALASFAADVVLLHAVGIRPVVVHGGGPQIGELMGRLGLVPEFRDGLRVTDAETLDVARMVLVGKVNRDIVTAVNAHGHLAVGLSGEDAGLLTASPRDPALGFVGDVGSVNPELLRRLLAEDLIPVVATIGSDGQGQAYNINADTAAGAVAEAVAAAKLVYLTDVEGIRAERDDPASLIHRTTPDGLDALVRSGAVAGGMIPKVASCSRAVRNGVPAAHVLDGRTDHALLLELFTDKGVGTMVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR76</accession>
    <name>A0A7K0JR76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000212">
        <property type="protein sequence ID" value="MST32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="42331" checksum="F010003C85FD1A41" modified="2021-04-07" version="1">MTDPAGPLAGVRVVECGTLLAGPFCGQLLGDFGAEVIKVEDPGAGDPMRQWGQVKVEGRSLHWPIIARNKKSVTADLRRAEGQALLRGLLERSDVLVENFRPGTLEKWGLGPAELAELNPRLVVVRVSGYGQTGPYAPRAGFGSIGEAMGGVRYLSGEPDRPPSRIGISLGDSLAATFAALGAVLALRARDRTGRGQVVDSAIYEAVLALMEAVVPEWELAGYQRQRTGSILPGAAPSNVYPTRDGDGVLVAANRDTVFARLAAAMGRPELADDERYATNDARGTHQAELDALVAAWTATQDADALLDALADAGVPAGRIYQTKDMLADPHFAAREAVVRLFHPQLGDFPLQNVAPKLSDTPGAVRTLGPELGAHNDEVYRGLLGLGDDELDRLRAGGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR85</accession>
    <name>A0A7K0JR85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000293">
        <property type="protein sequence ID" value="MST32441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="12078" checksum="025DD5D68439D839" modified="2021-04-07" version="1">MRPADSFLPDARDHRRRTRRQARHEARAWLRTAAADEELLEDADALCPKTVHDLGRHVSPPPPRPPKEGRRGGFKVWKTPYWKRRKALRRQRYAAAQHQARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR97</accession>
    <name>A0A7K0JR97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_06845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000291">
        <property type="protein sequence ID" value="MST32437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="4">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="106" mass="11295" checksum="E3DABC6E11CFA893" modified="2021-04-07" version="1">MLGRRPGLRGRLFTEHERAYAESMASPAVTYAGRFAVKEALMKSLGVGLGSVDWWDVETVRRDGGRPQLVVRGRAAALAADLGVGDWQVSISHTDTVASAVVAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE6</accession>
    <name>A0A7K0JRE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_07100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000309">
        <property type="protein sequence ID" value="MST32487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="23"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="412" mass="43281" checksum="950C526FFA2F3434" modified="2021-04-07" version="1" fragment="single">MVSGSPAARRGRARALGARTFSSLRVRNYRYYFAGQSVSLVGTWMQSIAQSWLVFTLTRSGTDVGLITAVQTLPILLLGPVGGTIADRFGKYRILLATQALAGVQAAVLSVLALTGSLQLWELFVMAASLGCINMVDNPTRQTFIVELVGRDQLPNAVTLNTVMVNVARAIGPAVAGVLIAQVGAGWCFFVNALSFVFVVAALVALRKDELLPTPRAVRAKGQLVEGFRYVSRRPLLRNALLMMAVIGLFTYEFQTTLPLMAGTTLHGDSQTYGFLTAFMGAGAVVGGLVAAGRGNRSPRRLATTALAFGASTALAALAPSTSTEELALLLVGAASVTFLSLANSTLQLEADPEMRGRVMSLWSVSFMGTTPIGGPLVGFVAGAVGARAGSHRPRSDPDGGAGTTPRRRHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRH1</accession>
    <name>A0A7K0JRH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000323">
        <property type="protein sequence ID" value="MST32530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="2">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="14679" checksum="6526803AC9B7C589" modified="2021-04-07" version="1">LARLPKVGQDGGGEAESRAANGDDAAGTEGGAPGSGGSLPGGAQPAAPFTVRHVVEHTPDGEAAYDLRVSEGQVRAHQAGAASADLTFTTDYPTATAIAAGKLSTDAALATGRLRVSGDLRALAHLAKTIGGVDPLPADLRADTEFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM6</accession>
    <name>A0A7K0JRM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000251">
        <property type="protein sequence ID" value="MST32234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="31874" checksum="F0088FB771EB253F" modified="2021-04-07" version="1" fragment="single">MPYRRLGRSGLKVSVLSFGSWVTFGPQLKGGGAEECLAAAYEAGVNFFDNAEAYAGGESERIMGESIRNLGWPRHSYAVSTKLFWGIHDGVVNMKNTLNRKYLTQAIDASLERFGLDFVDLVFCHRADPETPLEETVWAMSDMVSSGKALYWGTSEWKADEIRAAWEIAERHHLHKPVMEQPEYNIFSRRRVEQEYARLYDDIGTGLTTWSPLDSGLLTGKYVDGVPEGSRASLPGYEWLRDSVTDKDRNDAVRELQKVADSLDCTLAQLAIAWCARNPHVSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW0</accession>
    <name>A0A7K0JRW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000357">
        <property type="protein sequence ID" value="MST32675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="126"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="444"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="636" mass="65713" checksum="32DF3C4047DF7ED4" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY8</accession>
    <name>A0A7K0JRY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000365">
        <property type="protein sequence ID" value="MST32702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21853" checksum="7863A876FC7D2F79" modified="2021-04-07" version="1">MLRQAHNVSLWWESRDGTATGSGAAIFRVGRKGYHHLANMTRAEWDAWAAQPEDEPVRLAKVGALGYWRYQGRWYVEDENLTGADLRSLIVTQDQLRKARLNRARTIAAMAESPAPIPVRGAIPDDLRLLVWTRDQGRCRRCGSTSELQLDHIIPWSRGGATTAENLEVLCGPCNRQKGASVASPSRASPSALPSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ9</accession>
    <name>A0A7K0JRZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000367">
        <property type="protein sequence ID" value="MST32710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="254" mass="27223" checksum="981B4DB6199E1110" modified="2021-04-07" version="1">RARAALVTVTASRELRPGSPGGRSPLLPRYPDAAGYPADSAQGIVTNGRPPELSPDGRMRGDTCHLDVVDRFGNVVSATPSGGWLQSSPTVEGLGFALGTRGEMFWLQEGLPNSLAPGKRPRTTLTPSLVLGDDGLPSLAFGTPGGDQQDQWTLLFFLRHVHHEPDLQLALDAPVWHTSHFPSSFYPRTAHPGRVHVERTVGEDVLAALRARGHDVVEEAAWSLGRTTAIRRDPDGVLHAAANARGMQAYAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS42</accession>
    <name>A0A7K0JS42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000382">
        <property type="protein sequence ID" value="MST32761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="712" mass="77765" checksum="BAE11942738BA12D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS54</accession>
    <name>A0A7K0JS54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2252 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="483" mass="53187" checksum="1B454B80C494839D" modified="2021-04-07" version="1">MANVVRVVDHRLDAAGDHVRVARLQPGESAERGREARRAAPRSAHGEWSPPPDRRDPIEILREQAQGRVPDLVPIRYGRMVLSPFTFYRGAAAVMAADLAPTPTTGIVVQACGDAHISNFGGFAAPDRRMVFGPNDFDETLPGPWEWDVKRMAASVEIAAREVGLSAKRRRRLVTASARAYREGMRGFAGESHLDVWYDRLTASELVDRFGGHLGPSGRIVFSDTFAKARRKTSLRAVAKLTEEVGGRLQFRNVPPLLVPLRAHDIPAQHADEADYIRELLDEYTESLDEDRKYLFGTYRFVDMARKVVGVGSVGTRAAIFLLVGRDGRDPLVLQAKEAQASVLERHIGASPLANHGERVVRGQRISHAASDIFLSWQRSLGLDGREHDFYVRQLWDWKASLDLSTMREPGLLAFVRACGWSLARAHARSGDRLAIAAYLGPGPGFDRAIAAFAAAYADQNELDHERLVEAVAAGEVPAEAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSB2</accession>
    <name>A0A7K0JSB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_08810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000400">
        <property type="protein sequence ID" value="MST32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="12983" checksum="3FAE8847E380D505" modified="2021-04-07" version="1">MAGGPTQRRGRRPAVVHPRSHRHRARHRVGRGAGPRAARPAVSAFLVAAVALLVALVPCGWVCWRADPESRLVALSLAGTIEALVVLLIAVGSGEPAIASVAVVLVAMSVGGSLAFARFLERWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ9</accession>
    <name>A0A7K0JSQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-6A reductase</fullName>
            <ecNumber evidence="4">1.3.1.106</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_09565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.106" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="27549" checksum="1BF804A8E002E600" modified="2021-04-07" version="1">MTDPSRLLLLGGTTEASRLAETLSARHDLVVVTSLAGRTANPAPLPGQRRIGGFGGADGLAAYLRAERISALVDATHPFAARMRWHAYEACQQTGVARLRLERPRWQAQPGDRWTVVASMAAAADAIVRGRSRRVFVTTGRSELGMLAPASDGRRWWLVRSIDPPERLLLHPSEVILDRGPFSVDGETTLMARQRIDLVVTKNSGGTATAAKLEAARNLGVDVVVVDRPPSPDGPSTSTVADALDWVCASLGLSRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR7</accession>
    <name>A0A7K0JSR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">M24 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000446">
        <property type="protein sequence ID" value="MST32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="132"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="350" mass="36658" checksum="7CAD8EEE3615EFE9" modified="2021-04-07" version="1">MGEAGVDALLLSLGADLPWLTGYEAMPLERLTMLVLPADDRAVLVVPELEAPRVDDDPDVFEVRPWAEGDDPVALVAGMVGGRRRLAVSDRTWATFVLGLQEALPDREWLASSRVTGPLRAVKDDAEIEALAAVSAAADRVAAALLGGDIALVGRTEREVSEELGRRLVAEGHDRVNFAIVGSGPNSASPHHEPGSRRIGAGEAVVCDFGGAMAGYCSDITRTVCTGEPPAEFAELYALLQEAQASAVAAATVGTACEDVDRAARDRIAGGGYGAAFIHRTGHGIGLEEHEDPYIAPGNREPLRPGHAFSVEPGIYLAGRFGARIEDIVVATAGGPRPLNLASHDLTVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS2</accession>
    <name>A0A7K0JSS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_09635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="138"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="389"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="561" mass="60381" checksum="3D9E9DE6539F00FE" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV4</accession>
    <name>A0A7K0JSV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="10" type="ORF">GHK86_09930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000464">
        <property type="protein sequence ID" value="MST33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="335" mass="35243" checksum="D57D1D1B63449A06" modified="2021-04-07" version="1">MAVRVGINGFGRIGRNFLRAALGRDDLEIVAANDVMPTATAAHLLQYDSTHGTLDRTVTAGEDSIRVGDRDIRIFTGQTPEQLPWKDLGVDVVVESTGRYTDGKKAAGHLEAGASFVVISAPATNVDATFVVGVNDDTFDPAVHRVVSNASCTTNCFVPMVKVLDDAFGLEKGLMTTVHAFTNDQNLLDLAHKDLRRARGAAVNIVPSSTGAARATGLVLTAMQGKLDGSSLRVPVPDGSITDLTAILSREVTVEEVNAAYAAAAAEGPLAPVLTYTDAPIVSSDIVGSPASCTFDSLLTMTMGSMVKVFGWYDNEWGYSNRTVDLVALVGRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ7</accession>
    <name>A0A7K0JSZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="488" mass="53097" checksum="2077833C598C01CB" modified="2021-04-07" version="1">MAERTQVQLGPDPSRVVCQLFVAGEEFASGASRTSAVARRVLDLDDDAVDVELARVLRHFQGRHAHLAADLVAHFNQINQINQSSDDTSDFSVARRMLLGAYATSEYAVESAALCNPSIVAHPTQADVAAGALRVVLSLRAVGEGHVSSIEFRTGILDEDGDIHVDDPGRMAVAGRVEPGPYDRDAFASLLAVAGDDPELASAVLGRLPATFTRAELDVSMAELSARALQRSSVRELVDRIRTVADANYTVSFPEDTSIAQRVLRPGGPTESHGMEDARFVRFVDDDASVTCFATYTAFDGSRVSPRLLATDDFRTFTTSQLTGRAATNKGMALFPRRINGKYVALSRWDRESNAITTSADAHAWDEGTEIQRPRLPWELVQVGNCGSPMETEEGWLVITHGVGPMRTYSLGAMLLDRDDPRVMRGQLTEPLLEPISSERDGYVPNVVYSCGSIVHGDWLVMPYAYGDRTTTFARVPLAKLLKSILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT40</accession>
    <name>A0A7K0JT40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000481">
        <property type="protein sequence ID" value="MST33097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="73"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="27414" checksum="5700B0081AD5A3BA" modified="2021-04-07" version="1">RRTPGLRREEVASLAGVGMTWYTWLEQGRDINASEAVLDAVARTLLLDAHERDHLFTLAGVAPPPAPEDAGITPEVRAVLDRLEPFPAFVSNARYDLLAYNHAYQAVIGDLDALPPEERNSLWLIFTKHTTSKCFVDGAESKPRLVAQLRSAMAEHVADPAWKCLVRRLREASPEFEALWQRHDVAPPENATKRLLHPDYGLLQFNYVNTWLAPRIGLRLVVYVPADDGTAEAATLARDAVPLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE3</accession>
    <name>A0A7K0JTE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfC</name>
        <name evidence="7" type="ORF">GHK86_10810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000523">
        <property type="protein sequence ID" value="MST33208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="538" mass="58720" checksum="0A80C1264105909A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF7</accession>
    <name>A0A7K0JTF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArpA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000530">
        <property type="protein sequence ID" value="MST33231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="20499" checksum="C48E526713E1DCCF" modified="2021-04-07" version="1" fragment="single">EDTAAAARSGDVAVLATPRVVAYDLFPADSPLRALYEWDPLLRFVEAVLDRGALHRYADECGALNLAVMGEGDQLQWHFDMTDFVVSLALRDAEEGGDFEVAPRLRSAEDERYDAVGAVLAGGGGAVPVETLDMTPGTLLLFEGRHSLHRVTEVRGPTARWVALLSYDTRPGTRGSDRLRRVRYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ4</accession>
    <name>A0A7K0JTQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Agmatinase</fullName>
            <ecNumber evidence="6">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">speB</name>
        <name evidence="6" type="ORF">GHK86_11385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000557">
        <property type="protein sequence ID" value="MST33317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="346" mass="36671" checksum="12F2BE7E8969FEB1" modified="2021-04-07" version="1">MRIGNLYGPDATYLGVPAADLDEPSSWAHAKAVVIGAPFDGGTSHRPGTRFGPQAIRLADYLPHDGSRPHLALDVDPLLELGVVDVGDVEMPSGETETSLARLEAAVERIAGAGAVPVILGGDHTVALPDATGVARHVGWGRVSVLHFDAHADTGDTQFGTLYGHGTPMRRLIESGAVRGDRFLQIGLRGYWPEPETLAWMAEQRMRSYEMTEVVDRGLDTCLTEAFGIATDDCDGVFLSVDVDVVDPGMAPGTGTPEPGGLTTRQLLDAVRRICMELPIAGIDVVEVSPPYDHAEVTAYLGNRVVLEALSGLAWKARRDAGEAVRPPGAPLLEGRRPLPGTPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS5</accession>
    <name>A0A7K0JTS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000571">
        <property type="protein sequence ID" value="MST33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7184" checksum="C18061D2D866209C" modified="2021-04-07" version="1">MATGTVKWFNGEKGYGFISQDAGGPDVFVHFSAISGSGYRNLDEGQKVEYETSQGPKGLQAADVRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT1</accession>
    <name>A0A7K0JTT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3'(2'),5'-bisphosphate nucleotidase CysQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000564">
        <property type="protein sequence ID" value="MST33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="26192" checksum="6087980F406D8A35" modified="2021-04-07" version="1">MPAGDDGALAADLADRAGTLLLRIRGEGREAGARGDRSSNELLLAGLADARPDDAVLSEESEDDKARLAADRVWIIDPLDGTREYGMPGRSDWAVHVALWERGQEITAAAVGLPELGTVLSTAAPPPLGPFDPDGPVRTVHSDSRPPQWLPALGEAFPRLHAFPMGSAGAKAMAVVRGEADAYVHDGGQWEWDSAAPVGVALAAGLHCSRLDGSPLRYNQDRPYLPDLVICRREVAGDLLDALAEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU5</accession>
    <name>A0A7K0JTU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_11630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000574">
        <property type="protein sequence ID" value="MST33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="494" mass="51745" checksum="BA8B8B30580687F5" modified="2021-04-07" version="1">VAAALAAAAGSRVRLVRNGSRGMLWLEPLVEVVVAGRRIAYGPVAPDDVPGLLDAGLLDGGEHPLRLGPTEEIPWLARQQRVTFSRVGVVDPTSTADYEAHGGLAGLRRALAMEPAAIVAAVTESGLRGRGGAGFPTGIKWRTVLDTAADQKYVCCNADEGDSGTFADRMLMEGDPFLLVEAMTIAGLAVGATEGYVYVRSEYPDAIATFGAALDAARAAGWIGPSVLGSGRAFDLQVRVGAGSYICGEETAMLESLEGRRGVVRAKPPLPAIAGLFGKPTVINNVLSFAAVPRILAEGPEAYRDLGVGRSRGTQIFQLAGNVRHGGIVELPFGLTLGELVDEIGGGTASGRPVRAVQVGGPLGAYLPREQFGLPLDYEAFVAAGAMVGHGGVVVFDDTVDMAHQARFAMEFCAEESCGKCTPCRVGAVRGVEIIDRVLRGEDPDGNLELLEDLCEVMTDGSLCAMGGLTPMPVRSALLHFADDFRPRHREVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY2</accession>
    <name>A0A7K0JTY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000582">
        <property type="protein sequence ID" value="MST33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="21827" checksum="50C9862523A5C7FC" modified="2021-04-07" version="1" fragment="single">MRPGLAALPPGERAVTTTYDPRHPAYFDETDLRGELTRVYDLCHGCRLCLSLCPSFPTLFDLIDAKDGAVDALTAAEQDRVVDECYQCKLCYVKCPYVPPHEWELDFPRLMLRAEAVRRKHHGSLREKVTTQALGRTDLLGRVATATAPLTNKALEQPGSALRRVMDKVVGVAAERVLPPYAKVRFTTWFKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU04</accession>
    <name>A0A7K0JU04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">GHK86_11775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="WJHE01000579">
        <property type="protein sequence ID" value="MST33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="100"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="38231" checksum="C40F133792580277" modified="2021-04-07" version="1">MVGAGQLARMSQQAAVDLDVELVVLAESDRDPAVLAGAPHRLGGPRDREALHAVAAEAPVMTFDHELVPGALLRELEAAGHVLRPGAAALAFAQDKLHARSELAAAGFPVPAFRPVTGPGDVAAFAEEHGWPVVLKARSGGYDGRGVLVVDKPGELPELVWVGDDGRPAWLVEEHLDLAAELAAVVARRPSGETVAYPVVRTTQVDGICTHLVAPAGVATAIEAEASGLAVHLAERIGATGICALELFVTGDGRLLVNELALRPHNSGHATIEACVTSQFHNHLRAVLDWPLGATDLVAPAAAMVNVITPDADVDPAANLPAALAVDGAAVHLYAKASRRGRKVGHVTALGATTAGALDVAQAAVDTLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE6</accession>
    <name>A0A7K0JUE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_12680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000642">
        <property type="protein sequence ID" value="MST33572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
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        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="FAO_M" evidence="3">
        <location>
            <begin position="157"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="214"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="33447" checksum="7AF1EF72D37D7441" modified="2021-04-07" version="1" fragment="single">RLAGVELPVTPLRHQHLTTVPVPAVAALGRELPVLRDPEGSFYVRQDQGGLLVGPFEPRPRSWAVDGIPEGFHNRLLDPDLDQIQDVLAAVAKRVPAFAESGIRTVVHGPDGYTPDGLCLMGPVPDVAGFHVLAGFSIFGIVFSGGAGKYAAEWILEGQPGDSLWDVDVRRFGPHASGVAYTEARAKESYEREYAVHFPHEELPAGRPLKTDPLYDRLAARGAVFGARSGWERPLYFTPDPGGTDEPSFRRAAWHEHVGRECLAVAGGVGVLDQTSFGTYEVSGPGAAAFLDGLSANRLPAADGRVALTQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG4</accession>
    <name>A0A7K0JUG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000654">
        <property type="protein sequence ID" value="MST33595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="17785" checksum="9C627C0E537F9EA7" modified="2021-04-07" version="1">LGAVLLRYPGWFGPRPDTWAELAALPARLAGVRVAVELPEERWFGGDTTDDTLEWLEARGIGLVCVDGPPRPEAPPGPSVVAATSEVAVVRFRGRRQVEGESWTWPYRYDRRELAGWVPAVHDLAASGSEVHLLLDNCHRGDAVDNARTLQDLLRRRAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH7</accession>
    <name>A0A7K0JUH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_10890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000527">
        <property type="protein sequence ID" value="MST33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="374" mass="39761" checksum="768A51F45B868F46" modified="2021-04-07" version="1">RVTRCRFPQRSGLVADRAATEQVRAALRAGAPDGAVVAGSGTLNDITRYATHLESVDYVSVPTAASMDGYASSVAAMQFDGLKVTFPAHAPIGIFADLRVLAAAPAEMTSWGLGDLLGKVTARFDWVLSEAVTGEAYCPAVADRVAGPLERCAQEPDRLLAADEDGISTLIAGLVESGIAMAMVGSSRPASGAEHHFSHFWDLLAYRGLRPHAPHGLQVAHATAAVMRLQRAALADLDGGLRRPPGQRSADEDPWLGDLAVGAQVDAVRREKAERWEACAARWPPPAPALADARRHLESVTDAFPRVSAALRALGVPATGPDPAAPAGFHLDPPTLRATVRFANRMRSRFTVLDLLDSQGRIDRVADDLTTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM9</accession>
    <name>A0A7K0JUM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FliH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000673">
        <property type="protein sequence ID" value="MST33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="3">
        <location>
            <begin position="95"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="207" mass="21563" checksum="9C445BBDD4A37A5B" modified="2021-04-07" version="1" fragment="single">MTALSRDRILRAAPMRVGGAPALAARRPEPDSAPRPALLAELATPSERRLVAQEAGWEAGYEAGRQAAEREVAARLEEAAALVEQRRRQLTGLTAALEQAVDELRAATARRSQDLFAGMADAACQLAGAVLDRELRSDPHAVLDAVTRALAAAPEGPATVRVHPDDLPAVREAWAGSARLSFEADPAVAPGGCVLQAAAATVDATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR4</accession>
    <name>A0A7K0JUR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma B factor RsbW</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000692">
        <property type="protein sequence ID" value="MST33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="17507" checksum="4AEA45215BE3E42B" modified="2021-04-07" version="1">MIVALELEVPPSPEYIAIVRLVVSSLASARRNLADQRIDDLKLAVSEACTNAIEAHARAGHRRAVAVRVLEADERVEVEITDHGGGFDPDQLPLHPPVTDPSRLDFERGLGIPLIRTLVDLARFERLADGTRVRMIVFGGPAGDSGDETSEIIRAVLADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUV1</accession>
    <name>A0A7K0JUV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000694">
        <property type="protein sequence ID" value="MST33703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10345" checksum="D1E27B5ABE04CA07" modified="2021-04-07" version="1">MVHTPGCPHVAVLSGRLATALSRVGGTVPEVTLEEITDPDDAARRGFHGSPALLVDGVDAFAGPDAPTGFACRTYRTETGIEGAPSVEQLVATLTERGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY8</accession>
    <name>A0A7K0JUY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000558">
        <property type="protein sequence ID" value="MST33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFG_IV" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EFG_C" evidence="2">
        <location>
            <begin position="82"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="19206" checksum="4352BD8FBE30F2D9" modified="2021-04-07" version="1">RGGGFGFVDEIVGGAIPRQFIPAVEKGIAEAMAQGGHFGFPVVDVRVVCFDGKYHPVDSSEMSFKMAGSLALREALAKASPVILEPISSLEVAVPAEMQGDVMGDLNARRGRVQGTDTLEGGEQLVVAFVPTAELGRYAIDLRSLTGGAGRFRARHDHYEPLPTHLYDKVTAGAERAKVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV37</accession>
    <name>A0A7K0JV37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000589">
        <property type="protein sequence ID" value="MST33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="7764" checksum="E11893F6D8DA2CAB" modified="2021-04-07" version="1" fragment="single">MKIYTRRGDDGTTGLLYGGRVPKTAAVIAANGAVDEAQAALGVVRAEAERGSELDGLLVALERDLYVAMAELATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH6</accession>
    <name>A0A7K0JVH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ORF">GHK86_12640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000638">
        <property type="protein sequence ID" value="MST33564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="79"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="283"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="451" mass="47101" checksum="644F70D21BAB64D4" modified="2021-04-07" version="1">MDSRSVGPGALFACVPGRVTDGHAHAPAALAAGAVALLCERPLDLAVPQILVRSVRSALGPLAAAVNGWPSEDLVVVGVTGTNGKTTTCALLEAVFEAHGWKAATVGTLTQARTTPEAPELQRRLAELRREGCRAVAMEVSSHALDQERVGGVRFAAGVLTNVTQDHLDYHGTMERYFSAKARLFEPDRCAVAIVNRDDPWGRTLIARLGDAGTPLATYGLDDAEGLQVDVAGSRFRWRGQDVHLALGGRFNVANALAAAACAEQLGIPADVVAAGLGTLRAVRGRFERIDAGQPFTVLVDYAHTPDGLAQALTAARELTAGRLVVVFGAGGDRDQDKRPAMGRVAAELADLAVVTSDNPRSEDPGAIIADVVAGAADPTRIRVIPDRAEAIETAVWVAGPGDVVVVAGKGHERGQEIAGQVRPFDDAEVARQALERLLARRALSGPGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVT7</accession>
    <name>A0A7K0JVT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fliE</name>
        <name evidence="4" type="ORF">GHK86_13090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000673">
        <property type="protein sequence ID" value="MST33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="9329" checksum="1DBBA9F637CBC133" modified="2021-04-07" version="1">AATTPATGAVAAANAAAAQSASGSFGQVLGNALSGVQNLQTNADHLAVQAATGNLNSVTNYMVAANQADVATQLTVAVRNNAVQAFQQIMNMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU7</accession>
    <name>A0A7K0JVU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000678">
        <property type="protein sequence ID" value="MST33659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="15471" checksum="C5BD0DA0A898E59B" modified="2021-04-07" version="1">QMAAKELEAYRQLTGSFDQHPVLADCYRALRRYGDAEALWDDLRTASPDADLVAEGRIVAAGCRADQGDLRGALALLERGNRNVEHPRDRHLRQWYVLADLYERAGELPRARELFGRVLGADPEAFDVRQRLRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVV1</accession>
    <name>A0A7K0JVV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hemB</name>
        <name evidence="13" type="ORF">GHK86_13270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="WJHE01000690">
        <property type="protein sequence ID" value="MST33684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="34705" checksum="F0CAE1A445D2B0D6" modified="2021-04-07" version="1">MPYPTTRLRRLRRTPALRDLVAETRLGVDDLIAPLFVREGIDGPQPIASLPGVVQHTVESLRKEARRLADLGIRGVVLFGVPARKDAEGSGAWDPDGIVQVALAELRADLGGQLALMADLCLDEYTDHGHCGLLDARGEVDNDATLERYARAALAQAAAGVDVVAPSGMMDGQVGAIRAALDGAGRTDVAILAYAAKYASALYGPFRDAVDVTIAGGGDRRGYQQDLRNARESLREVALDLEEGADLVMVKPALSYLDVIAAVRRRFDVPVAAYHVSGEYAMVMAAAERGWIDGPAVALEQLTAVKRAGADVILTYFAGPVAEALHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX1</accession>
    <name>A0A7K0JVX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_15380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000850">
        <property type="protein sequence ID" value="MST34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029733423" evidence="3">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="24856" checksum="ABFBC7CE07801BC3" modified="2021-04-07" version="1">MVPLLLLRVAPGRASSAGQLPPATARPVAGRGVAGSAGTGPAGGGTVDSVATTASYHFSLDLASPRTILPSQPPGDGRLTRRLHSLQCGELAQSLQRSWDVMDQPGRSAAVQRWMAERMAQRGMSQSELVRASGVSAFTIRKVMQGVAGRYQAAKLAKISTALGGPAEALRLLYAGETPPAAPSPSAVSADELAAAGDRLAAVEAELREVRAQLARLNERFLPAAHREEGSESAAPPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB1</accession>
    <name>A0A7K0JWB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-TA family PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000744">
        <property type="protein sequence ID" value="MST33844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-ser_dehydrat" evidence="1">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="197" mass="20058" checksum="427307729E6CD224" modified="2021-04-07" version="1">RVAGVFTFPGHSYAPGAAAGALADEGRALEQAAASLAAAGLPCELRSGGCTPTAPSTPGGVVTELRPGVYVFNDAQQVALGTADLDDVALCVAATVVSVPAVDRVVLDAGSKVLGPERPPWVPGHGLLPEHPGAVVSGLWEHHAVVDPGPHRLRLGDRVAVVPNHVCTAVNLATELLVASGGEVVDRWAVTARSRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD2</accession>
    <name>A0A7K0JWD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000751">
        <property type="protein sequence ID" value="MST33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="13"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="28502" checksum="5A2577950D10626E" modified="2021-04-07" version="1" fragment="single">MDDELAAAIVPFADALGADPGDLAWVPNVTYGLNLIARSLMGRLEPGDEVLLTDLEYGSQLMLWHWVCERSGAILRLAPIAGTPPNQVADVIVGCASPATRVALVSHVTSASAQRLPVEDVARRLRERGVVVVVDGAHAPGQIDLDLPSVGCDYYAGNLHKWFGTARSAGVLYAPGPEAQRGLDPLVVGWGGTDRAEPIARRVHLPGTVDPSVYLSAPAGLSFHREVLTPARPAARERLAAAAGALEQLGWARVGRHEDDLLMAAFLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK0</accession>
    <name>A0A7K0JWK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000919">
        <property type="protein sequence ID" value="MST34262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="331" mass="35308" checksum="374C304C5FB51473" modified="2021-04-07" version="1">MLLCEGGTGVEQGLAGLRRAGRPLVLSHWPSVRHGDRPVGHRASVRAVLTISTSLGQVAYDSKGSGAPVVFLASGGHDAHDFDELRQRLPGRFRSIAIDWPGHGDSPAWRDPPGEVQLTRMVEEVIDALCPTGAVLVGNSIGGNVSARLASTRSDLVKGLMIIDSSGFERPLGHAGRAFCTLMGHPGFVRAIYPLFSKLYMRARTDADRRARASAIALTRTENGARALSAMWQSFKLPSHDLRSRASSIAAPTVLVWGRHDPIVAPKCGRAANELIAGSKLVLVDSGHAPQTTIPDTVAAQLIALLDVAFPAGDPGELSEPPFLSRKDHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWK4</accession>
    <name>A0A7K0JWK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000947">
        <property type="protein sequence ID" value="MST34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="18605" checksum="E0D36B2429A67BB0" modified="2021-04-07" version="1" fragment="single">MPARSREDLVALAAALHDCRSGQLPPGAQVERLRQALEPLVRRRYDRPEPRLADLDALARLATSAPTRAALVAELTLDPPSSTGDLAGPPGLDDDWLTLSTVHSAKGGEWDAVHLIHAADGAFPSDLATRDAEGVDEERRLFYVALTRARRHLHVYAPLRYHHGDPAGFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX37</accession>
    <name>A0A7K0JX37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_17160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001008">
        <property type="protein sequence ID" value="MST34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="21244" checksum="7CFC1C32D25145E0" modified="2021-04-07" version="1">MAEGSGDRAGNPQLEPPPPAGELDACVAAALAGDETAAANVFRAVQPALLSYLRSQLPSDAVEDAAAEVWLAVARGSAASVRSFDQLRALLFTIARRRVIDLRRGQRRRPVSLGEEAAEPVASDPTDGFVERLHADETVRRLMQLLTPDQAEIVLLRVVAGLSADAVAAVTGRTAGSVRVIQHRAMRRLAAEVQARVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX41</accession>
    <name>A0A7K0JX41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">cofH</name>
        <name evidence="18" type="ORF">GHK86_15515</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000860">
        <property type="protein sequence ID" value="MST34124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="433"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MST34124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="751" mass="80855" checksum="0125D62FD5C19F87" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX95</accession>
    <name>A0A7K0JX95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AcetylCoA_hyd_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000877">
        <property type="protein sequence ID" value="MST34159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="1">
        <location>
            <begin position="85"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="22352" checksum="CE79CAF1289EC45E" modified="2021-04-07" version="1">MAVGERERRIAAAVAGLVPDGATLQWGPGALGAAVVAALTRPVRVHAGVVTDELVGLAERGLLAGPAVAAYLWGGPGLARLATAGAVRLASVEHTHDPARLAAIPRFVAVNTALEVGLDGAANVEGPRGRPVSGPGGHPDFCLGASRSTGGLSVVVVRAEVAGRSAIVARPAVVSTPRTDVDVVVTEHGVADLRGRTDAERAASLIAVAGPAHRGGLRAAATTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE0</accession>
    <name>A0A7K0JXE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001106">
        <property type="protein sequence ID" value="MST34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="161" mass="15848" checksum="96311E4359BFAC21" modified="2021-04-07" version="1" fragment="single">MLSRVHLITDTRFGRDPLSLVPAALEAGVDAVQVRVKELGDRAALAVVGKAVALCARYGATCIVDDRLDVALAAGAHGVHLGADDLPVARARAVAGPGLLIGATVRDPASARAAVVDGASYLGTGPAYVTGTKGGLPAPIGVAGVEAVCAAVDVPVIAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF8</accession>
    <name>A0A7K0JXF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001119">
        <property type="protein sequence ID" value="MST34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="235"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="447" mass="45090" checksum="5F5A78D4E1D69146" modified="2021-04-07" version="1">MGHPAALGPLGRRLAAAFVAVALVALGSYALLTVLAERAGVGGLARTHRAVTAGAVVSVASNAYRASGGWAGADLGPVRVLADLSSAAARLSDQDGRVLFQTGSARLLTSARGAPVSRPVVVDGAVVGRVRLAFAPDGLTSPERRLRQALSNAAVLGVGVSVAVAVAAALTVSTFVVRPIRRLSAATAALGRGDRSVRVGASAGRGELSELGAVFDDMVTALDEADAARQAMIADVAHELRTPLAILQAETEALVDGVRPATPEALGSVHDETIRLGRIVGDLQALASAEAAGLSLERRRVDLATVAAEAADALAGRFESSGVGLDRRLAPAPVDGDPQRLHQVVVNLLTNAGKFTPEGGTVRLDVRLVGGAAELSVTDSGPGIPADEQGRVFQRFYRGSAGRHTAGTGIGLAVVAQLVHAHGGTVCVTTPAGGGARFTVSLPAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI4</accession>
    <name>A0A7K0JXI4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsaD</name>
        <name evidence="8" type="ORF">GHK86_18265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01001132">
        <property type="protein sequence ID" value="MST34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="27"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="34733" checksum="681BE089B6F2917A" modified="2021-04-07" version="1">MKPVRVLAIETSCDETAAAVVDDGRHVRSSVVSSQVDLHARFGGVVPEVAGRAHLDLLTPVVEEALERAGTSGPELDVVAATIGPGLIGSLLVGTAAAKAYALAWGKPFVGVNHMEGHLHAAFLEDPDMALPAVVLLVSGGHTMLILMTRDGRYRLLGQTIDDAAGEAFDKVARFLGLGYPGGPAIDRVARDGDPAAVAFPRGLLHEGYDFSFSGLKTSVVNYVKKHPEVGVADVAASFQEAVVDVLVRKATRAAADVGARGICIGGGVAANSVLRERVQEACAAHGLAAFVPSRAMCTDNAAMVAATAWHRFRLDGPTPLDAAADPNLRLALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM2</accession>
    <name>A0A7K0JXM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001159">
        <property type="protein sequence ID" value="MST34700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="297" mass="31358" checksum="949951C7D241A2F5" modified="2021-04-07" version="1">MTLRVGNAPTSWGIEKPSDPSYPTWSQVLDEVAGAGYAGVELGPLGYFPTDPGALRSELARRELELSAGVVMDVLHDAGTADAVVDKARSICALLQPLGTDRLVLIAGWTPSRVETAGRPGAAERLGASDWQRLIDTVHRVATVAAAAGVATTFHPHAGTDVEFGDEIDRLLDDTDPSLVGLCVDTGHARYAGVDPAALLRARAGRVNHVHFKDVDPGVLERVGQDELSFWDAYRQGVFCPLGRGCVDFGDVEGALGEIGYDGWATVEQDASPTGDSVPLDDARESLAYLRSVGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ2</accession>
    <name>A0A7K0JXQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001185">
        <property type="protein sequence ID" value="MST34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15993" checksum="B1844BED76E6A261" modified="2021-04-07" version="1">MDLSDVESLAAPEHHLAVVATTRADGTAQASVVNAGVLAHPVSGERVVAFVTYGRAKLANLHHRPHATVVWRNGWQWIAVEGPTELCGPDDELAGVEPAAVPELLREVYRAAGGTHDDWDEFDRVMREERRTAVLVAPQRIYSNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX0</accession>
    <name>A0A7K0JXX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001231">
        <property type="protein sequence ID" value="MST34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="394" mass="41902" checksum="1FCE34CF167EEDD8" modified="2021-04-07" version="1" fragment="single">MTTDRPLEPVASDRRSQAWFAAPGRNGFLHRSWLRNQGHTDEAFDGRPVIGIVNTWSELAPCNGHLRQLAEVVKRGVLMAGGYPFEVPAMSLGETLVRPTAMLYRNLLAMVAEETIRSNPLDGVVLLSGCDKTTPGLLMGAASVDLPAIMVTGGPMLNGKFQGRDIGSGTAVWQLGEELRAGRITEADFAEAEVCMSRSPGHCMTMGTASTMACLVEGLGMTLPGAAAIPAPDSRRVATAQRAGQRIVAMVEEDLRPSRILTREAFDNAIRLNAALSGSTNAVVHLLALAGRVGVPLDLRDFQALTDDVPVLADLVPSGRFLMEDFFYAGGVPQVLAELGDLVHTGHVTVTGRTVADDIAGTRCWNRAVIATRDAPVQPAGSGTRVLWGSLCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY58</accession>
    <name>A0A7K0JY58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_19530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001291">
        <property type="protein sequence ID" value="MST34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="25602" checksum="4FF0B7D64B994E40" modified="2021-04-07" version="1" fragment="single">MTTGGPPGAGGRAGRSRRLRAALTPREWAGMAAMAGVILGLNVLGWTLIGIAAAGHYRIGAKEAFGFGTGILAYTLGMRHAFDADHISAIDNTTRKLLADGKRPLSVGFWFSLGHSSVVFILAVLLNFGIRGLDAQLKTGSSALEHTTTIVGTAVSAVFLFLIAALNLVILRSILQIFRSMRRGTYDEAELERQLNSRGLMMRVLGPLARRVDSGVKMYPVGFLFGLGFDTATEVALLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB7</accession>
    <name>A0A7K0JYB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001323">
        <property type="protein sequence ID" value="MST34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="62" mass="6175" checksum="DAA9FE8C0532A845" modified="2021-04-07" version="1" fragment="single">MTLDRALGALWGLALGDALGMPTQSLPRSGIVARFGPLLAGLEPGPPDQPLAPGLPAGSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC1</accession>
    <name>A0A7K0JYC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L,D-transpeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001327">
        <property type="protein sequence ID" value="MST34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="16505" checksum="50E69AD45ACE9D4F" modified="2021-04-07" version="1">MRPLLWPALLAAEEAHRTDPVGYTYALVSQDLPESLTLWHDGTDVYTSVANTGLPSRPTPTGTYFVYRRFPSTTMAGSNPNGSYYVDHGVRWVNYFDGGVAIHGFVRASYGFPQSLGCVELPVAHAAVAWKWIHYGTVVTVLPGPHPTPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE2</accession>
    <name>A0A7K0JYE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001332">
        <property type="protein sequence ID" value="MST34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="24230" checksum="B1A9C8649356504A" modified="2021-04-07" version="1">MAGEGRVVLVTGGNRGIGLAVARAFQAAGDRVAVTSRSGEVDGFTTVACDVTSAEDVEAAFARIEAELGPVEVLVANAGITADQLLLSMKEEAFTRVVDTNLVGTYRVVRRATSKMIRARKGRIVLISSVVALTGSAGQSNYAASKAGLIGFGRSLARELGGRNVTVNIVSPGFVETDMTAVLPEARQAEILAAVPLGRMATADEVAAAVRWLASDEAGYVTGAVVPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ6</accession>
    <name>A0A7K0JYJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TetR_C_33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001097">
        <property type="protein sequence ID" value="MST34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TetR_C_33" evidence="4">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="74" mass="7634" checksum="80E09884A565D3C4" modified="2021-04-07" version="1">MPPGLAAWLEGIRSPELADLPDGLLALALLAYSHLVGVVSSEVFGHFGADATPAAELFDHELRLSAALLGLDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM6</accession>
    <name>A0A7K0JYM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001393">
        <property type="protein sequence ID" value="MST35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="217" mass="21730" checksum="8D126F6ACDFE9A61" modified="2021-04-07" version="1">VAALADAAGVRVIADEIHAPLVLAGASFTPYLSVEGAGRGFSLASASKAWNLPGLKAALAFAGPAAAADLARLPEEVGHGPSHLGVLAHTAALRDGGPWLDDVLSGLDRNRRLLTELLGTHLPAVTWQPPAATYLAWLDCSALPLPAAGGADASARGDASANVGVAAWFLDRAKVLLSSGPAFGAGGERCVRLNFAASASVLTEAVTRMGQAVAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ8</accession>
    <name>A0A7K0JYQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_20485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001426">
        <property type="protein sequence ID" value="MST35095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="195" mass="21760" checksum="5208435F29B48EE5" modified="2021-04-07" version="1">ALAAWWEPLLAGAPTLRRALGGRLVLDAGAYGVVLDPGEGRVRPWQGEAWEHWFGFAPEVLWSLVDRHVTDWVNEAFLSCRFEADRVGGYNDAVFTFFKCLEPGRMAYLERTLADAERDAEGPVAREDTFRCGDYLVQRRCPHLGADLSRFGEVRGHVLTCTLHGRAFDLRTGACLNGSEPPLRTERVAGERSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT7</accession>
    <name>A0A7K0JYT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001439">
        <property type="protein sequence ID" value="MST35110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017196">
        <property type="entry name" value="ECF_substrate-spec_UCP037395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037395">
        <property type="entry name" value="UCP037395_ABCper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="265" mass="27042" checksum="4A5D11858F2D659E" modified="2021-04-07" version="1">PLGSRSGLAVALASGFGVLAFGWPFFVAPGPLGGSLVPPLMFGALLLIVLAVVLAQLADGGMDSKAVAMLGVLAAAGAALRPLGAGTAGIETVFFLLIVAGRVFGPGFGFALGCVTIFTSALVTGGVGPWMPYQMFASAWVGMGAGMLPRVPPRWERVLLAGYGAVAGYAYGLAVNLSFWPFSVDPSSSIAYRPGAALLTNLHRYVIFDATTSLGWDTGRAITDVVALLVLGPVLLAAFRRAARRAAFDAPVGFSDAPDGGEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ1</accession>
    <name>A0A7K0JYZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001431">
        <property type="protein sequence ID" value="MST35102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="11832" checksum="DD532862F9E1D975" modified="2021-04-07" version="1">GARDGVARLAAAGARLAVVSNSDGTVAATLAALALIPEGVPVLDSATVGVAKPDPAIFALALARLGVPAARAVHVGDVPSADVVGARAAGVRPLHLDPIGWCGAGDHEHVAALGEVADLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ52</accession>
    <name>A0A7K0JZ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001251">
        <property type="protein sequence ID" value="MST34844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="392" mass="40384" checksum="5F3F90F6EA3CD7C3" modified="2021-04-07" version="1" fragment="single">MATQAEVRWAALALVLFLLALAARGAGVGWAADVCFAGCYAAGGWEPGLAGLRALRDRSLDVDLLMVVAALVAAGIGQALDGALLIVIFSTSGALEAVSTRRTREAVTSLLTLAPERASRLDQDGTESIVDAEALRVGDRVVIRPGERIAADGRVLTGASDVDQASITGEPLPVAKTPGDEVFAGTLNGAGALTVEVTRPAAESVVARIVALVQRASETKARTQLFIDRVEQRYSIGMVTVTLALFVVPLLLGAALQPTLLRAMTFMIVASPCAVVLATMPPYLAAIANAGRHGVLVKSAVAMEQLGETTRVAFDKTGTLTRGVPRLDTVRTLTAGLGEQQLLAWAAGAEAASEHPLARAVLDAARARDLAVPAAGGFVSQPGRGVTATVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ65</accession>
    <name>A0A7K0JZ65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001498">
        <property type="protein sequence ID" value="MST35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="73" mass="7572" checksum="E5384B4DD5F29598" modified="2021-04-07" version="1" fragment="single">MHPGRSTRLGARRGHHGPVDVAALLLTGGRSRRMGRDKAALVVGGRTLAQRTADLLRRAGLGGPLLELGPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ73</accession>
    <name>A0A7K0JZ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decaprenylphosphoryl-beta-D-ribose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001573">
        <property type="protein sequence ID" value="MST35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="20690" checksum="2450915698CC44F9" modified="2021-04-07" version="1">GLLNRWSVGAFNELWYRKAPRRRLGHLVPAAAYFHPLDAVGSWNRLYGPRGFVQYQLAVPDGAEDVVRLAIERFSAARVASFLAVLKRFGAANPGPLSFPAEGWTLALDLPASSRGLSPLLDELDERVAASGGRVYLSKDSRLRPDLLAAMYPRLAEWRRVRDGVDPQRRLSSDLARRLDLLGPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ87</accession>
    <name>A0A7K0JZ87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001526">
        <property type="protein sequence ID" value="MST35218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="7995" checksum="8534CDA56A6034E2" modified="2021-04-07" version="1" fragment="single">TGAAGGTPAGGLPAGGVLGPGQSIVSGNGQYQLSMLPSGDLVETSGTATLWSTSTASPGASALLDADGQLEVLAPAGTVVWSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ92</accession>
    <name>A0A7K0JZ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001589">
        <property type="protein sequence ID" value="MST35291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="25432" checksum="FBFF13CBBDC5571C" modified="2021-04-07" version="1" fragment="single">MPDPLAAVAGWPVTAAVAVVTADGIGAAAGDLDRPRPWASVSKLLTALSVLVAAEEGTLSLDDPAGPPGSTVAHLLAHASGVAPDGPRVLAPPGTRRIYSNAGFELLGQALEDAAGMPFAAYLRAATIEPLGMVATTFTGSPAAGAHGPLRDLTRLAAELLTPRLVSPATLDAASHVAFPGLDGVLPGYGPQRPNDWGLGFEIRGHKDPHWTGRSNSPATFGHFGLGEHPADRQPVAGRAERQLRQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH1</accession>
    <name>A0A7K0JZH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_21440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001581">
        <property type="protein sequence ID" value="MST35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32479:SF17">
        <property type="entry name" value="PTHR32479:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="11931" checksum="23FB4B722C6E22D6" modified="2021-04-07" version="1" fragment="single">MNLGLDEGLDTCVQCGLCLPHCPTWRVTGDESRSPRGRIALMRSVQTGSVAVTDEVVASFETCVLCRGCETACPSGVPFGHLMEQTRDSLAAAAMALWNPRLLMTVTTTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZS2</accession>
    <name>A0A7K0JZS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001668">
        <property type="protein sequence ID" value="MST35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="12183" checksum="7E8D1F5D672C123F" modified="2021-04-07" version="1" fragment="single">MQISARADYGLRALAELAARQDRSHTVTELAAAQGMPARFLQNILLQLRRRGLLQSQRGVDGGYRLARPAAEITVAEVLRALEGPLAGVRGALPEHVEYAGTAEPIADVWLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K071</accession>
    <name>A0A7K0K071_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001513">
        <property type="protein sequence ID" value="MST35199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7776" checksum="752D0974EA4C441A" modified="2021-04-07" version="1" fragment="single">MRVEVVRSPRRRKTVQAREVNGVLRVSIPATMTKADEERWVQEMVRRMARRAATEAVDLGRRAEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K095</accession>
    <name>A0A7K0K095_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_21110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001527">
        <property type="protein sequence ID" value="MST35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="3">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="260" mass="26858" checksum="ACAFCB90EB7D8EB0" modified="2021-04-07" version="1" fragment="single">AARLAGRSVALVLGGGGARGLAHLGVLHALEDAGVVVDRVAGTSSGAIVAAAYALLGSADAADELVFEEMVVAEPLAGWRPSRGGLIRGDRIARGIERSLGGHRLEALSRELVVVSTDLYRREPVYHRVGPLDEAVAASVAIPVLLPPRRVDGRLLVDGSLTDNVPAAAFGDLPEGPMLAVRIAPPASEVVPDRLPGFGDLLFRVLQMSDRDSAAAGAPTPSVSVVADTRGIGFLEFHQIDAAREAGRRAGEAAVEALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMQ6</accession>
    <name>A0A7K0JMQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cas1</name>
        <name evidence="10" type="ORF">GHK86_00310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000014">
        <property type="protein sequence ID" value="MST31173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="542" mass="58306" checksum="78121323783E0AAA" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV3</accession>
    <name>A0A7K0JMV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000028">
        <property type="protein sequence ID" value="MST31275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029509613" evidence="1">
        <location>
            <begin position="36"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="440" mass="46115" checksum="391E0CB0AFD3E841" modified="2021-04-07" version="1">MTRQIRSSRLFLAGVLASALLLSACGGGSTTPSSSAGSKTFGSGATGVVHFWARSATSATAKLMVKEFNASHKHLKVVLTETANGEAVTKLATAIRAGAPPDLIGLNDIDMPIFSHEGAFMNLTKYVDALPYKSSLSPGHLGLATYEGKYYGVPYLADLSVLWYNKKLFAEAGISSPPTTFAAILADAKKVQALGHGNHGFSFAGDCEGCLGFTMLPDVWATGTHLISGSIPHQKASVAGNSALKQLLTLYRTIWADHLYAPGDRTQNGTTWGANFVKGHTGIFPGGYGSIRPKLTSADRANFADVPLPGPSGGYSTFDGGDDFAIPKGASNPSGAWEFIKFVLAKAQQLQYPSTGFTPVRTDLLNASYKAAHPFDSVALKALAKGYAPTTLAYNSIFNQPSGPWFGMFSEAVYQGKLSAAVSAGQSGFTQQLSQSGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMV4</accession>
    <name>A0A7K0JMV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000027">
        <property type="protein sequence ID" value="MST31268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="64"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="243" mass="24781" checksum="9358784337BFBEDD" modified="2021-04-07" version="1" fragment="single">MSTAVTPVAPPPASGAWQPGDPPGDRRFVTLFADRPLRLEGGGTLGPITVAYETWGERASDDANAVLVCHALTGDSHLSGPAGPGHATAGWWDGIVAAGAALDARRWWVVCPNVLGGCQGTTGPASGDADGRPWGSRFPALTIRDQVAVEVALADALGVGRWAAVVGGSMGGMRALEWTVSQPERVARAVLLACGAVATAEQIALSALQSEAIRLDPGFAGGDYYAAPAGAGPWRGLGLARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNA4</accession>
    <name>A0A7K0JNA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GHK86_01245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000045">
        <property type="protein sequence ID" value="MST31357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST31357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="8576" checksum="A7479C91015D9E44" modified="2021-04-07" version="1">MAEGKCRELPPETFFPSDGVGVELARRVCADCPVKEPCLEYALYNRIEHGVWGGASERERRRIARRRRGVISVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JND5</accession>
    <name>A0A7K0JND5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000075">
        <property type="protein sequence ID" value="MST31476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="28927" checksum="BB2F1AD5D850903A" modified="2021-04-07" version="1">MSVGDFEGAGVRNIAKVGAGLATVVLAMAVGLPSAAAAVTSGTIGADISYPQCSATGGAPSEPSAGSAAFGIVGVDNGRPGAANSCLAAEYQWASALPGSPALYVNTADPGNTVADWPTGAIAGGPQNPYGPCVTVRSRGKLAGADSQACAFEYGVEQADNDLRFAAAAGASTTSWWLDVEAANTWQKRRLLDLNQAVLDGMDRTFTASGTGPTVGVYSTAYQWGTIVGTLTGAALGDLGAVPQWIPTGGSSEAAAAADCSGTSLPRFDQGPLTFVQYTTSFDYDYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK7</accession>
    <name>A0A7K0JNK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fpg/Nei family DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000081">
        <property type="protein sequence ID" value="MST31493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="5">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="15293" checksum="166FEBE6B5083284" modified="2021-04-07" version="1">PLRPDADGTAVWPRLARRRGPIGVALMDQSCVAGVGNVYRAEALWVHRIHPERPCATLSPEEWSGMWATLVTMLRAGLREGRIATVRPGDAVPDGRTRWVYKQERCARCGGTVRRWDLAGRWAYACETCQPPWPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL0</accession>
    <name>A0A7K0JNL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000014">
        <property type="protein sequence ID" value="MST31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="230"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="492" mass="53875" checksum="B53C69E42EDD9DB3" modified="2021-04-07" version="1">MTVEEAGSASEAKAWVEANRSVVEEAYRRFAKTGEWPGAAELQRHFDQRAVPVDVQKAIDSKPSVGQEGRLPHADRLVLAIRHMMWLSSASTLVDLCFEAVVRSVTSYLSETDTPGVTSIELAKETSASGTDLARVYSVLTREHPSPFGGSSQLPDGQWRIEADSRFARRFRDLNSIESFVERQDIIRAEAATEMAALLALPQFRTPLSPYAEPSARVDETAESPEPVLFVSWGRPASKAIARALVPVLESRLPGVEIFFSPTSIEPGADPSRRMFDEGLLRSSALVVVLTSESAESPYVIWETATAWARDQLVIPVFVDIEPGRVPGPLTSKVQGVKFGERSDLDRALNRLAAQFGSPPSPPLSEEEYTQLVAAAEIVLDVDPKLARRALLDQLRGYLARWQVLYESLEGHPSVDERVRLAAEVEQVLGELLRAAVTTGDDPALATALSALAKEATAVRRTRVLLDGGRSFRQLDDGCRSLLERIAALLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL8</accession>
    <name>A0A7K0JNL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster repair di-iron protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000094">
        <property type="protein sequence ID" value="MST31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019903">
        <property type="entry name" value="RIC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36438">
        <property type="entry name" value="PTHR36438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="18550" checksum="EF615843599DD9C1" modified="2021-04-07" version="1">AADAGDWTGYGPAELARHIQAAHHVYLTAELPELVSLADKVAGVHGDRHPELAEVTRLVRALHDELLPHLAKEDRVLFPAIAALEAGPASFGFGTVANPIAVMTAEHEAAGELLGRLAAATSGYETPADGCASYALLYRRLAHLEADTHLHVLKENSVLFPAACALEAERQAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS8</accession>
    <name>A0A7K0JNS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="13372" checksum="BEB95B10361E2CD2" modified="2021-04-07" version="1">MTKLTPAQVDALRDAFGYWPDAGSEHGPIELEYAILGEEWLRVLVGATVDLDPESDQVEEIIDVLLDAEVVGVVDAYYPIWPEEDEDDRRWAVVAERLSAAPACARRRSRPGGSCCSRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNT0</accession>
    <name>A0A7K0JNT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethylglycine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000106">
        <property type="protein sequence ID" value="MST31616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCV_T" evidence="1">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="2">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="22478" checksum="B86C862FCA8C349B" modified="2021-04-07" version="1">DTSDAGIPFFGSVDTHVGAAPVRVLRLSFVGELGYELHHPLEYQRYLYGLLCDAGADLGLVDFGYRALESMRLEKCYRLWGADLTSDFTPLEAGLGRFVQLEGRRFVGRDALAGQAAAGVTRRLCCLEVDADDADAHGWEPVTHAGKVVGHVTSGGYGHRVGRSLALAYLPAGLAEPGTALGVEIIGSCRPAAVVAQPVYDPANHRMRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU7</accession>
    <name>A0A7K0JNU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029459782" evidence="1">
        <location>
            <begin position="37"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="374" mass="37489" checksum="0446D167DA19EFF3" modified="2021-04-07" version="1">MPVPTRGNPTVSNRIRRAASLAAGLALTATALTACGSTSSSAGGGSGSSGGGGQASAGTQTLNVGQISKSVAFFPVYVAQKEGYFTAQHLHVPNPPLLGTGAKVAAALVSGSIDVGAGVMTDAFNLANAGQQPRLVSDLINSYYVDIVVANHFSGPPASASLKQRIAALKGKKIGITGPGSGTQALVDYLFKLDGLDASTQATLVNLGSGNSAAVDALKSHEVDALAFFQPVGQLAEALHVGSIYISPARGDVPGLQGATNGVVYTTAGELSSKKTAIEAFIRAIGQAGRFIHTSSTATLVPVLRAYDTGLSAAVATSLVSVLKSEIPSSPSFNQAGYKAEATVNVVGGLIHSAPKYNTLVASSVIKAALGTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY6</accession>
    <name>A0A7K0JNY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000113">
        <property type="protein sequence ID" value="MST31676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="27333" checksum="77DAA181A3FA5949" modified="2021-04-07" version="1">KYANAHGVAVIDYDRLTLGSNAPYYVSFNNVEVGKLIGQGFVSCASKWLGTKKPDVIVMRGAPTDNNATLFAQGYDSVLKPYFSSGKYTDAANPPGTWTPSTALTEFQQAYTAHKGVNSAVIPNDENGAPIISYLKTQGIKPDTFPTTGQDATLVGLQNIISGYQCGTVYKPIYMEAQATAALAMYLRAGEKPPSALVNGTTEDTTLHKAIPSVLLPPEWVTPKNMESTIIADKFVPASQLCAGSYAADCSKYGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP99</accession>
    <name>A0A7K0JP99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000053">
        <property type="protein sequence ID" value="MST31379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="PTHR10801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="465" mass="52318" checksum="15E1895C9FF8897E" modified="2021-04-07" version="1">MPPVAPAVAPSEAWAAYRRRVAGLVEQYRALPAGSPVRLAKRTSNLFRPRASAAGGLDVAAFDGVLSIDPDARTADVQGMTTYEHLVDATLPHGLMPLVVPELRTITLGGALTGLGIESSSWRNGMPHESVLELDVLTGDGRVVTARPDNEHRDLFFGFPNSYGTLGYALRARILLEPVTPWVHLRHLAFGSVAALAGTVREVCATGTHEGEPVAFVDGVWWGPQECTLTLGSWQADPPPVVHSYGGQAIYYRSVRARSEDWLTVRDYLWRWDTDWFWCSRAFGVQRPGVRRLVPPRLLRSDTYWRILAFEQRFGVKGALDRLLGQPEREAVVQDVEVPLERLEAFLEGFAREVPIEPVWLCPLRSRDPGRRWPLYDLDPDALWVNLGFWSSCPLAPGMDPDHHNRWVEAEVDRLGGRKSLYSTSFYDEERFWSLYGGGDYRRLKAAYDPDGRLLDLYQKCVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC1</accession>
    <name>A0A7K0JPC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000146">
        <property type="protein sequence ID" value="MST31820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="22329" checksum="A640D9E10A6564E2" modified="2021-04-07" version="1" fragment="single">MATVTAVVASTHHPFYYRASTATGADRPPFADEWTARIEAFRATLTAADPEVLVLVGSDHFHQLWLDNMPQFLVGKAPWFDANWYNEEREFGLPRMRLRGEESLAAHILREGLDAGFDLAFSNELRIDHSVTCPIITLRPEADLPIVPVYTNIFAPPLPRPRRFVELGRALRRIVESWEDDRRVAIIGTGHLSLELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF1</accession>
    <name>A0A7K0JPF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_03745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000153">
        <property type="protein sequence ID" value="MST31840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="791" mass="82857" checksum="1BEBD817C6816E3E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI8</accession>
    <name>A0A7K0JPI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="11269" checksum="D2EC240E96620DAB" modified="2021-04-07" version="1">MRCPWCDFEGPLRPLHAHLAVSHPEQVRFEDRSGGDRQVYAVACPICGAGYEQTIKPRHAPDFVDEYRREIRLVAFDMLLNHLVGEHEPHAGAGPNPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK0</accession>
    <name>A0A7K0JPK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000157">
        <property type="protein sequence ID" value="MST31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="137" mass="14881" checksum="15AACD650C90ABB0" modified="2021-04-07" version="1">MSGFDPGLPEQPDLEMSVAAVLANNTDVKMLLRVLGKSLQDSLGDRVEIRHAGGGLLHRRGDEVQAVVVRLDPDEYEADLEAHGVRCTVGRSSGGIRIRNEQLPVEEWLHRLLAALQQEAAGNQAARQALQDLVVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP3</accession>
    <name>A0A7K0JPP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="771" mass="81845" checksum="41B9EA2B3B733C29" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPU4</accession>
    <name>A0A7K0JPU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000187">
        <property type="protein sequence ID" value="MST31978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019278">
        <property type="entry name" value="DICT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
        <property type="entry name" value="DICT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="356" mass="37902" checksum="5F5073C14DBC5C7E" modified="2021-04-07" version="1">GLLGELDWACRAAALGAARRSALHPSLTWMVNVDPASLHQPCPTDLRPVISAAKTRLRVLTELTARGAGERPGELLQATADARQSFWGVALDDVGRAPEPLALLPFLQPDVVKLDLGLLRNRSAIEAASVANAVRAYAEATGAVILAEGIEGGDDLEWARDLGATYGQGFHYGHPGPLPEGLAPPRHPFPFSQRFEIDPSLTPFQTLSASRPIRRAGRRRLTAISRQLEAQVLASGDAPVVLTSFERPGAYTPEVQQRLELVTSRAAITIVAGAGIADRVQGPVSAADLAVDDPAGREWAVVVVGPNFAAALAATRYDGALPGLTYDYVLTYDRPAVISAGRALLQRVTRSERRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY2</accession>
    <name>A0A7K0JPY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_04485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000189">
        <property type="protein sequence ID" value="MST31983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="131"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="45412" checksum="8F9895D5DA1FEA96" modified="2021-04-07" version="1" fragment="single">YVNDAPHIGTAYTTVTADALARWHRLLGDEVLFLTGTDEHGLKMQRAAEANGLTPREQADRYSRRFVETWRSLDISNDDFIRTTEPRHYETVSKLMQAAYDNGWITLGTYEGLYCVSCEAYYTEAELLDGALCPIHRRPVETLTEDNYFFRLSAFEERLLEWFDSRPDAVIPESKRNEAIGLVKGGLRDVSVSRTSISWGVPVPWDPAHVFYVWYDALINYATAAGYGRDPERFAAWWPVVHHLIGKDILRFHCVYWPALCMAAGIDPPRQVAVHGFLLVGGEKMSKTALNQIAPADLLPTFGSDGFRYHLLRDQPFGPDGDFSYEGMVARYNADLANNLGNLLSRVATVVGRKCGGIGPAPDPASPLAGVVAEASRAAAAAWERVAPSEALDATWRIVRETNAALEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ17</accession>
    <name>A0A7K0JQ17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="140"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="539" mass="59931" checksum="7E67E7E7B36D7028" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ71</accession>
    <name>A0A7K0JQ71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrR</name>
        <name evidence="6" type="ORF">GHK86_04935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000204">
        <property type="protein sequence ID" value="MST32071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20736" checksum="E33058A32E36CE73" modified="2021-04-07" version="1">MVERDGPSTPPHGGVFVPRTTVMEPDDLRRATWRMAHEILERNRGPEDLVLIGMQKGGVWIAERLVGVVREVSGADVPCGTLDVAFYRDDIGLRPVLSEEATDIPVDLTGRTVVLVDDVLFTGRTVRAALNALADHGRARAVQLAVVVDRGHRELPIRPDFVGKNLPTRRDEVVDVSPAGVVIGEQDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ85</accession>
    <name>A0A7K0JQ85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_04985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000208">
        <property type="protein sequence ID" value="MST32081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="538" mass="57393" checksum="27A6DB68F76D5B01" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ97</accession>
    <name>A0A7K0JQ97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="7881" checksum="2567E33FFBD3A181" modified="2021-04-07" version="1">MTMSPTILIGQDIFPENRSMGSGIALGLANGIGALLVLAIGRTVGNGDLSTALWDIVALTASTAPLAAAFPGHLLHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE0</accession>
    <name>A0A7K0JQE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000221">
        <property type="protein sequence ID" value="MST32141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16458" checksum="69C1DE1CE877DDA9" modified="2021-04-07" version="1">MTTTTHPTPGTASEPTAAPRIVVGIDGSEASRAALQWAAGQARLTGARLQVVAAWQFPTYAYTALAPLPSTLDLRTTTEETLRDVIADVLGRSADLDVTHLTKEGDPAHVLLEAAEGADLVVVGSRGHGAFAGLVLGSVSERVAAHARCPVVVVHAPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI1</accession>
    <name>A0A7K0JQI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000234">
        <property type="protein sequence ID" value="MST32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9231" checksum="BB3B91EBFCC0A598" modified="2021-04-07" version="1">MGRRTGIVVNAFAVVYGAVMTVNLVWPRASFYGPAWYQQYAAVAFVPAVIIIGIVYYRTRLQTTPTAGTANLSADYTPQPSTGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL4</accession>
    <name>A0A7K0JQL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000160">
        <property type="protein sequence ID" value="MST31874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="18925" checksum="D8088F4BE415AE3D" modified="2021-04-07" version="1">MSEVPPAPDNWWWREGAERRGPAVVFDMDGVLSDAASRQHFLEEPRRDWEAFFDAVGDDAVVEEVARLLELLDPGLVVVLLTGRPARVQPQTQAWLHRYGLRWDLLVMRDFGDYAAAREFKRRAVDRLRAAGLDPRLAFEDDRRNVAMFHAAGVPCVYIHSGYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQN1</accession>
    <name>A0A7K0JQN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000254">
        <property type="protein sequence ID" value="MST32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="371" mass="39206" checksum="F2D74FFB48BDF689" modified="2021-04-07" version="1" fragment="single">TPIPPDEQRAAARRFAAHHQASATFGREHLPATAVRGIIFARLANLVDGHAKCRPLVAERVAGLLEQPPPRVPLAGEVFSGEIVPMMRVMVGIDPDELEEGEPMALVNGSPCSAALAAEVALRSRNRLGVAEAVFALSVEALGAPLEAYDPALRDLWGDPFETAALDALGALLEGAAREGRRPFQAPVSWRILPRVLGQAHRAVAAAEEVAAIALRSVTDNPVYLPPDEEHPSGRVFSTGGYHNASAYPAIDGVSGSWADLCAIAERHTMKLHDGDASLLPHHLAGEDGSPTTLLTLVQTGLGEEARHEAARTFLPMSESGGFGGQNDVPSPTFLAYGRHGRVAWCLDACLASLAVTASRALWLTGREPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU8</accession>
    <name>A0A7K0JQU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ldh family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000269">
        <property type="protein sequence ID" value="MST32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="432" mass="44569" checksum="C6ACA864BD17FAC7" modified="2021-04-07" version="1">MDGPGGGSNGDPTGPPRRGALVDVVREARSAVNVGCRGWGSSSTALAPRRQRLHGALDPPPPGRWGRAPRPWSASPTWCVSTVPDRGLPVGVVGWEQLRGWAVQVLRLAGASEEAADATADACLYASRRGLDSHGIAYLATYLPRLREGLIDGAARPAVVGGTDALAVIDGRSAAGAFVARFAMDWCCDRAARHGIAAAVVRNSNHFGAASCYADRAATRGCVGMVWSNSDAAMAPEGSLAPALGTNPLAVAAPGTPMPSLDMSTSVVAHGRVAAAARAGELLPAAWGIGRDGQPTRDPAEVLANAVLPMGGHKGFALAFMLEVLTGCLAGGSVGPDLHQERGACHLFVAIDVDRAGGRPAYEGALARLVSSLHDVPRVEGAEPLRYPGEGAAWTSERRRGGLELDESTAATLRQLGEEWGAPFPPEHAEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR28</accession>
    <name>A0A7K0JR28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000279">
        <property type="protein sequence ID" value="MST32367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="54"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="26637" checksum="6A854E065E76C799" modified="2021-04-07" version="1">MVESAEANAAIWKSDATVADWVAGADARERGRVRARELLAELLPFAEDERFTFVDLGAGTGAASRAVLAAYPSSSAILADYSPQMREEGQRSLADYAGRYRYVELDLATGRWPEELAGGLQAVITSLCVHHLPDARKAALFAEILARLEPGAWFFDYDPVAPDDPSVGEAWQRVQDRRDPEAASKRSHRSPEEQARWENHVRHISPLGPQLGYLRAAGFEAVDVYWKELDHVILGGRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR71</accession>
    <name>A0A7K0JR71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000286">
        <property type="protein sequence ID" value="MST32403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="64"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="403" mass="42577" checksum="298D42CF76C1EB04" modified="2021-04-07" version="1">MTTQSAPPVYRFARRTEGAGDGVSAILSLADPGDTITFSGGFPAPETFPTEVLGQLLGDAVSSAAPVALQYTATEGLAALRGTLRSWIAAGQGAEPADDALMVTSGGIEALSLLARCLVDPGDRVLVEGPTYLGAITAFTGLEGRVEAVATDEEGLDPDALAAALASGPLPKLLYVIPDFQNPTGRWWTTERRRAVVEICRRHGVPVAEDVAYRELAFAPEDRPSLWSLGPDVVVQVGTFSKIFFPGVRLGWAAGAPELIGAMVAAKQNSDQCAGGLGQWLVERYLAGGHLEPRLAVARRLYAERAAALQAALARHLPAGCSWTRPEGGFFAWVTTPAGVDTTALVPEARLRGVAYVPGAPFFPGRAETHHLRLSYSRTDADQIEEGIRRLGGLLASAIEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR77</accession>
    <name>A0A7K0JR77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgP</name>
        <name evidence="12" type="ORF">GHK86_06905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000294">
        <property type="protein sequence ID" value="MST32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="848" mass="93901" checksum="44548DDC8B283E17" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR78</accession>
    <name>A0A7K0JR78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="5954" checksum="8B52998A74504A9E" modified="2021-04-07" version="1">MDDDCANCGVPAGDLAPVHRVYLLPEPVLVDEVERWCLSCRTQYPHEVADRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRA3</accession>
    <name>A0A7K0JRA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-phosphate galactose phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000305">
        <property type="protein sequence ID" value="MST32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="21582" checksum="CF0405C69BAC52AD" modified="2021-04-07" version="1" fragment="single">ARRRGRLVEAALIVGAGEMGVRLAEDLAAHPELGAVPVGFVDTVPSPEPLPLPVLGPTDELSRLVEATRASRVLVCYPVERDRDLVPLLRACRSRHVDICFVPRFSELGVAIPRSALDEVWGTPLLPLRRGLAAPGAGAAKRGVDVVVATVALLVAGPLLLALAAVLRLRHGAPVLFRQTRLSTAGRSVRVVKLRTLPPQAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRE2</accession>
    <name>A0A7K0JRE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplC</name>
        <name evidence="8" type="ORF">GHK86_07255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000315">
        <property type="protein sequence ID" value="MST32518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="212" mass="22121" checksum="859873C0BF391B69" modified="2021-04-07" version="1">MPSKAIVGEKVGMTQVWDTDNRAVAVTVIRVTPARVVQLKTPDRDGYAALQVTYGPPAKVNKPLAGHYGKADVEPGRTLVELRIDDSSAYAVGQELSVDSLAAGDKIDVTAVSKGKGFAGGMKRHNFKGQGASHGNHKHHRAPGGIGACATPARVFKGTRMAGQLGSDRVTTLNLEVVSSDADRNLLLVKGAVPGPRGGVVLIRDAVKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ4</accession>
    <name>A0A7K0JRQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000344">
        <property type="protein sequence ID" value="MST32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="16818" checksum="19B5E749212854A3" modified="2021-04-07" version="1">MPAPVPPTDRDAAVTRYLQLRPLIKARLAEAMPADLREEFATVTPHQVRALLALPRAGLSMRQVAAALGVTGATASVLADRLEGQDLARREHDGEDRRVVRLVPTDRGWSLAGRVAAAERETARLLFDRLSDPQVAAWLDVLETLAAADVLEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU2</accession>
    <name>A0A7K0JRU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000347">
        <property type="protein sequence ID" value="MST32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019795">
        <property type="entry name" value="Globin_bac-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01213">
        <property type="entry name" value="GLOBIN_FAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="15111" checksum="6C301A629156941C" modified="2021-04-07" version="1">MRHPGGVAPPTLYERVGGDAFFEALTRRFYADVRRDPVLAPLYPADEADFEAARFHLQQFLVQFWGGPATYNEERGHPRLRMRHAPFVIGRPERDAWVRHMLDAVAASGAGAMERAQLVTYFESAATHMINAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY2</accession>
    <name>A0A7K0JRY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000366">
        <property type="protein sequence ID" value="MST32708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="321" mass="34231" checksum="77671CF1A7E85FCF" modified="2021-04-07" version="1">MPGSPPDGPVPPYDQLPDAGSGGRTAWGLWGSDESVGRLHLQTPQRVAAAARLVRRGAVFALDAALGAVDPPLTSARGVPRHRVLHEPGPGLVATDDVWDNLYPQAGSQWDSLAHIAYRPGVFYNGATDDDILCGRRNTIDHWARRGIAGRGVLLDLARHLGHAPEDATAYRVEQLEEVRRAEGVEYSEGCVILLRTGFLGWYTGLGRPERSRARSPLRAPGVEHTEAMARYLWDSGAAAVAADTYAVEVWPPDFGDDAAPWGFLHRVLIGALGFALGELWDLDALAADCAADGVYDCFVTSAPLHAPGGIGSPANALALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ6</accession>
    <name>A0A7K0JRZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000367">
        <property type="protein sequence ID" value="MST32711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="290" mass="30098" checksum="0FB0B054EB046136" modified="2021-04-07" version="1">MRSGPGTRSSSPGEPSCGRASPWISTRSEGDVEPLVAVVTGAGEGIGRAIVEDLLATTPARVVAVDRNPRLLDRLLAAPGGRVRAVLGDVAEWATHESAADAAAEEGRLAWWVNNAGTDVAGGAHEVTADDIAAGLRVNQYGPMYGTAVAVRRLMPHGGSIVNISSIQGMVAFPRYFAYQSAKAAIIMLTRGVAMDYGRHAIRCNVVCPGTIASPMFERGLSEDPTERARQIGLEEAMAPLGRVGTTAEVAKAVTFLLSDDASFISGAVLTVDGGASTRCFAYPTGDSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS65</accession>
    <name>A0A7K0JS65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_06680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000287">
        <property type="protein sequence ID" value="MST32404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="8">
        <location>
            <begin position="109"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="27361" checksum="09A067171BA42B92" modified="2021-04-07" version="1">MLREAGPGGNDGPVGQGGRFGDSLNSRHVFGHVFGIEVVIACVVFGAVLGLIVLAGIWSHHKRRNGQEPWRKSEHHLVEGTYTVVLAGVTAFIVFLSFTSNAKPAHVPPAKVGVYVTAYQWCWRFTYQGTGVSITATCEDGHVPTLELPTHTVVHMSLISADVVHEMWVPHLRFKMEAFPDHVNAWDTELYSTGTWPGRCSEFCGIYHYAMHFYLKAVTPATFTTWLHGEQAKLHSGHTLAGNSGEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS77</accession>
    <name>A0A7K0JS77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000395">
        <property type="protein sequence ID" value="MST32806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="22763" checksum="5F92155D5698C01C" modified="2021-04-07" version="1">MRTTFDPDDLGARRFYRLLTAVVVPRPIAWVSTVSVEGTHNLAPHSFFTVSCVEPPVIQFTSVGRKDSLRNVEATGEFVVNLAPRTLFAQVNATATDFPAAVSEFDAVGVRREPSCLVRPPRVADSPVALECRLHATIGLGDSTVVLGRVVLAAVASEVLDGEHPDVGRLAPLARLGRDEWGTDPTVLEISRIRWADWPGHYRSDGAADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS99</accession>
    <name>A0A7K0JS99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_06855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000292">
        <property type="protein sequence ID" value="MST32439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="109"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="23310" checksum="546E948A2C0D019D" modified="2021-04-07" version="1">MLGHGAPPLSARGDHPRPVPAAQESLVPCRQRARGTAPEGPGTTAGPSGRGVRLARRRGSPGRVAIRGAPGPQTLVTVTAPDRPDVPAPAAAGGRSIGAAFDPRRNARDLLRLVLALLVVVSHALVLGRHRSEVLWRCGTLGGIAVDVFFAISGYLIAASAAHDHVGRYLWQRFLRIFPGFWACLAVTAVVAGPVAWIASGRPFGACGAPSGPPHDRAGPPTPGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA5</accession>
    <name>A0A7K0JSA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF4040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_08820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000400">
        <property type="protein sequence ID" value="MST32822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="80" mass="8288" checksum="EF76F0613AD5AF10" modified="2021-04-07" version="1">MKDVVIAVALVWVAVAGTAVVLTREPLRQAFTTGLFGLALATLYFSLQSGDVALSEVAVGAIALPLIILLALAKVQKRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL6</accession>
    <name>A0A7K0JSL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000430">
        <property type="protein sequence ID" value="MST32917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="68"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="495" mass="53829" checksum="94EE09078C458AFB" modified="2021-04-07" version="1">MSDPVPAAATPQPGRPLLLRGGCVLTMDDAHRVLPAGDVLVVDDRIAAVGPRLEAPPDAFEIDAAGGIVMPGMIDTHRHMWQTAMRGYGADWTLTQYFVWYYLEHGRAFRPEDVHAGNLLSAWESLEAGVTTTVDWSHGLQTVDHAEAAADALQAVPGRFVLAYGNIHAGPWEWTADPAVRAFLERRRTGAGDLLGFQLAFDVTGDPAFPERAAFEAARELGLPVTTHAGVWGATNDDGIRLMHEHGFMTPETVYVHAATLSTDSYHRIAATGGTASVSTESEQSAGQGYPPTWQLRRHRIPVALSMDTSVWWSGDLFSAMRTTLGADRSREHLEAHTNGETVTHVHLRAEQVVDWATRGGARALGRDDLGRLEVGAKADVVVLKNDASPVSFPLLNPYGHVAFQAQRADVHTVVVDGRVVKHDHRLVGADLPAVRRLADATIEHLRSTLGEEAWAAGMNPELPGDDEVLDNPYQYTDYKSDRTRRAHTPFGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSQ3</accession>
    <name>A0A7K0JSQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CbiG_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="171" mass="18290" checksum="7A163BC41780DE3B" modified="2021-04-07" version="1">MPSSTGPRSLRPCSATWWSCQSVGECRRAGWAYASERRTRCSSAGGPRPEMFTLGVGMSSSARLADLREILGRVLVEAGWTWNEVAAVGTTRRLVDDQRLVQLGARLVGFDRSELEAVAVPSRPSSAARRLLAPPVAEAAALLAAGTGSRIVVPKRVGRHVTIAAAVREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS8</accession>
    <name>A0A7K0JSS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000449">
        <property type="protein sequence ID" value="MST32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="330" mass="36236" checksum="8DCA1D19329612AB" modified="2021-04-07" version="1">FDYIPEFFKAETADSEAEADRWYEDKRNNRRPPELLPRDEVARAINNEIKEGRGSPHGGVFLDIASRRSAEYIKKRLPSMYHQFRELAEVDITAEPMEIGPTCHYVMGGVEVDPDTAASRVPGLYAAGEVAGGMHGANRLGGNSLGDLLVFGKRAGEAAAAHAGAVGAAGPSVSEDDVASAARTALAPFETEGGENPYRIHHELQDAMQDLVGIIRREQEMQLALKAIHDLRDRCRTLSVEGNRQYNPGWNLALDLRNMLLVSEAVALAALERKESRGGHTRDDYPMTDYDFWGKRNVVLELGGDGALGLYHQDLPEPPPELAGLLEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU2</accession>
    <name>A0A7K0JSU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000449">
        <property type="protein sequence ID" value="MST32993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8786" checksum="70DC200D81F0B91C" modified="2021-04-07" version="1">MTDAHDTIDEVAPFLATWRAELSGQTSVAAGEVQDHLLDLWSQLPEGDRRAKVEAWLTETLSRHLYPVEELEERLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY4</accession>
    <name>A0A7K0JSY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">pgk</name>
        <name evidence="12" type="ORF">GHK86_09935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="WJHE01000464">
        <property type="protein sequence ID" value="MST33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="336"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="386" mass="39875" checksum="93BB4A1A8F43FBB3" modified="2021-04-07" version="1">MELPQLEDLPDPSGRNVLVRADYNVPLVDGRITDDLRIRATLPTLTWLLDHGAARVTVCTHLGRPKGKADPRYDLAPVRARLGELLAGAGADAARVTLADNLRFDPGEEANDPAFVDRLVEGQDLYVDDAFGAAHRAHASIVGPPQHLPSAAGRVLAREVEVLSSLLEAPARPFVAVLGGSKVSDKLGLLESLAERVDTLVVGGGMCFTFLAARGHRTGASLLEPDQVDACRRLLASGKTVLLPTDLTVLAPGGTFGPGNPPTGEVRQVGADVPDGWSGLDIGPGTAAEFADAIEAAATVLWNGPMGVFEDERFAAGTRTVAEAVAATRGFSVVGGGDSASALAAFGLAGRVDHLSTGGGASLELLEHGDLPGLAALRAAAARQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT31</accession>
    <name>A0A7K0JT31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1380 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000377">
        <property type="protein sequence ID" value="MST32744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13701">
        <property type="entry name" value="DDE_Tnp_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="17"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="400" mass="41788" checksum="B2C9D078D2100173" modified="2021-04-07" version="1" fragment="single">MVKRNRRGRLRVTTGAVGVVGHAGARLLVDLAETLGLGEGLSAAMAATRTRGGGHDRGGVLADVAVMIADGGEAISDLAVLRDQPGLFGEVASHATAWRALAAVDDAAIGRIGEARAEARAVAWAAGADPGFYVIDIDAALVGSHSDKQQAAPTYKRGFGFHPLMAYLDATGEALAGLLRPGNAGSGTGADHVRVLDDALAQLPIDPATLEVIVRTDSAGCSHEFLDAARARHVRFVVGHALTAAIAAAIVDLPEAAWVPAVSADGADERDGAEVAEITGLVDLAGWPPGTRMIARREDPHPGAQLSFTDVDGHRFQVCVTDLADTDIAYLEALYRGRGRAERSIADHKDTGLANLPSASFAINTAWVQLSLIAMDLLAWSRLLLLDGVLAHAEPKRLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTB7</accession>
    <name>A0A7K0JTB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000383">
        <property type="protein sequence ID" value="MST32769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029579748" evidence="1">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="18983" checksum="B6C35C03135080D8" modified="2021-04-07" version="1">MATVVAAAFVVGGLLVAGSTPPARRSSPVTVPIRGVRVYLDVSGRSPDHPGETHLTFDGNPRTSWWTDAYLGPDKAHFGGLYDGEGLAIHLARSARLQRLTVMSSTRGWAASTYVSTHGVAMSAPLADWGQMVSSRRNLQGSASFDLRGRSGDWVLLWLTDLGPAGLANVAELQIRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG9</accession>
    <name>A0A7K0JTG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000534">
        <property type="protein sequence ID" value="MST33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="17528" checksum="B732331079A6BB07" modified="2021-04-07" version="1" fragment="single">MSQPRSSLHVVESPSPTDSGRAPVRLLVHGSMDRAGSFGRLAAALGRRAVVTYDRRGYAGSARRAPSEDFGVQVDDLLEVVDGRRVVALGHSFGGCVVLAAAAAHPELFVAAVVWEPPMPWLAYWPADAPGGLAAASRSSPEDAAEAFMVAAVGERVWRRLPAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM9</accession>
    <name>A0A7K0JTM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000553">
        <property type="protein sequence ID" value="MST33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="55"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="504"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="599" mass="63373" checksum="47F46CBF05087C3E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP9</accession>
    <name>A0A7K0JTP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aceE</name>
        <name evidence="12" type="ORF">GHK86_11370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="WJHE01000557">
        <property type="protein sequence ID" value="MST33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="203"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="493"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="910" mass="101063" checksum="6FA527F5F3500C01" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV6</accession>
    <name>A0A7K0JTV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="69" mass="7257" checksum="DF1DC86079958853" modified="2021-04-07" version="1">MTQDDSAVVDDRRYHRFVYRQDGVEARLDHPDRSARVGIDWAQPPDATGAGRGPGAASPAPGPGEVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU12</accession>
    <name>A0A7K0JU12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000594">
        <property type="protein sequence ID" value="MST33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="280"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="508" mass="53781" checksum="229EEB99B10B39BC" modified="2021-04-07" version="1">ASGHDFYAAPAVSPDGSRLAWLSWDHPEMPWDATECWVAALRPDGSATDAQLVAGRDGESVQQPRWSPDGVLHWISDRTGWWNLYRQAEGSGTPAGHEAEGSGTPAGHEAEGSGTPAAPGVPLCPLEAEFGVPSWVFGLHTYDFLADGTVVATWHGPDGGGIGVVAGGGVLPFATPYRGFEYLAGDGDAVAAVASSPTEPPAVVRLTPDGTTRVVRRTRDAGVAPGSVSVAEHIRFPTAGGEEAWAWFYRPANADFEGPAGERPPLVVKTHGGPTSAADPSFDLGIQYWTSRGFAVADVDYRGSTGYGRAYRNRLRDSWGVCDVEDVVAVTRWLAGRGEVDADRCVIRGGSAGGYTTLAALAFTDAFAAGASYYGVADLGALARDTHKFESHYTDRLVGPWPEAEATYRARSALFNLEGFDRPLILLQGLEDRVVPPAQSEAIFEAVRGKGVPVAYLPFPGEQHGFRRADTIVAATRAELSFYGLVLGFTPDGAVELAVENAGALPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC1</accession>
    <name>A0A7K0JUC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000633">
        <property type="protein sequence ID" value="MST33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="309" mass="33936" checksum="7BD2107793ADE731" modified="2021-04-07" version="1">MCGIAGVIHRNGPSDIGREMTAMLQSMKHRGPDSTGFALYGSGAEGTVMRIKLADPRERGAIGWEEDLERRLLEVQSRLTKVGADVAEVDRTTDYAVRAVIDFDGDLKSLVDHVEDIPGCEVLSAGTSLEIVKDLGDAAEVAAQYGLGKFRGTHAIGHVRMATESDVDIAGAHPYWAYPFGDVAVVHNGQLTNYHQWRRRLERLGHRFASECDSEIIAVYLAEKLHNGVSLETAIKESLDDLDGVFTYVVVTKDSLGVAKDEMAAKPLVLYETESMVALASEEVAIRAIIDQEIETYDPYEREALVWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUD4</accession>
    <name>A0A7K0JUD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000639">
        <property type="protein sequence ID" value="MST33566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="9832" checksum="BCC79AA3D40D176D" modified="2021-04-07" version="1" fragment="single">MLELAGGPLDVVIDGYGAPTWPGALRVLRPGGRLVSYGDTGGATATVAVDEVYWQWRSILGTSMGSPRDFRRLLELAGGPLDVVIDGYGAPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ9</accession>
    <name>A0A7K0JUJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-1,6-bisphosphatase class 2</fullName>
            <ecNumber evidence="4">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000653">
        <property type="protein sequence ID" value="MST33593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16905" checksum="72D6ED6F2BED9016" modified="2021-04-07" version="1">DRPRHARLIEEVRATGARIRLISDGDVAAALATAWPASGTDILLGIGGTPEGVIAAAALKCMGGEIQGRLWPRDDAEREAAVARGYDLDRILHTDDLVGGGNCFFAATGVTDGELLRGVRFDGQGAATESLVMRSRSGTVRRIEARHRLTKLAAYAPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK5</accession>
    <name>A0A7K0JUK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000666">
        <property type="protein sequence ID" value="MST33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="22364" checksum="C6F42BCD8C444247" modified="2021-04-07" version="1">MASAELLLHPVRLRIVQAFLGDRTLTTAQLAAELGDVPPASLYRHVALLTKAGVLQVAAERRVRAVVERTYMLRAHAAQVQPDEAAAMSPEQHLAAFMAYAAGMLADVERYLTTGTPDPQRDGASYRVGAMWLSDAEHAELVRDLVAVFQPRLANPPAKGRRRRTLYNVSVPAPEDPGPRTPTRTARAAEAPTPATRGRSGRGEGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL1</accession>
    <name>A0A7K0JUL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="15148" checksum="2B3DEC126F6B0D2B" modified="2021-04-07" version="1">MPVGIARDSDGRITGYFLYEGDADLATLSGSDRELWPALAWMADGLDPGDAAARHPVLGPCGALIERWCERRALFPLAQLLPAYVQGPQGLSAWKSLLAGLEHLERVAAGTQLLPDDEREMLSQLLHETKRIVRTGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUM5</accession>
    <name>A0A7K0JUM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpD</name>
        <name evidence="13" type="ORF">GHK86_13050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="WJHE01000670">
        <property type="protein sequence ID" value="MST33641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="160"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="482" mass="52476" checksum="4909EBE2F7568586" modified="2021-04-07" version="1">MTTAVEEHSSESPELAEGRVVAIAGPVVDVEFPPGDLPEINHAVEMDVDLEGATTTIVAEVAQQIGEGRVRCVCLQPTDGLKRGTPVRNTGRGITVPVGSGVLGHVFNVTGRPLDTDRVEGIEDRWEIHRPAPEFEDLEPRSQMFETGIKVIDLLEPYVQGGKIGLFGGAGVGKTVVILELINRVAQQHGGVSVFAGVGERTREGTDLWLEMQESGVIEKAALVYGQMDEPPGVRLRVALSALTMAEYFRDVKDQDVLLFVDNIFRFVQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTKGRSITSVQAVYVPADDYTDPAPFTTFTHLDATTELSRQIASLGIYPAVDPLASTSNILTPEVVGERHYTVARRVQEVLQRNRELQDIIAILGLDELSEEDRIAVSRARKIQRFLSQPFFVAKVFTGIDGEYVPISETVESFEALVNGDLDDVPEQAFLNVGGVEQVLAKAKQLQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP5</accession>
    <name>A0A7K0JUP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine synthase</fullName>
            <ecNumber evidence="6">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">metH</name>
        <name evidence="27" type="ORF">GHK86_13085</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000672">
        <property type="protein sequence ID" value="MST33648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="16 19" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 19 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 21 27" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 21 27" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 19 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="23">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="24">
        <location>
            <begin position="332"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="26">
        <location>
            <begin position="621"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="25">
        <location>
            <begin position="715"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="20">
        <location>
            <begin position="725"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="773"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="830"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="MST33648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="871" mass="93038" checksum="BC91E418FF18BDF6" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUR1</accession>
    <name>A0A7K0JUR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannitol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000688">
        <property type="protein sequence ID" value="MST33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="1">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="14237" checksum="034BF3DB7F2C6655" modified="2021-04-07" version="1" fragment="single">MTRLSSAALPALPAGVGPRVDPGRLGVGIVHLGLGAFHRAHQAVLTEDAVAAAGGDWGICGVTQRSGTVRRQLAPQDGLYGLLERGDGGCDVRVVGALREIVDGSSDPGTVVGRIAAPEVCSTRPAATAASKALPPASRTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT0</accession>
    <name>A0A7K0JUT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000694">
        <property type="protein sequence ID" value="MST33701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="17558" checksum="42A8AE6E24C72EF5" modified="2021-04-07" version="1">MSPRAACRLESLGFTAVYDYTAGKVDWLAAGRRTEGPGAATLRPGSVARTPVPTCSLDDTVGDARQRAAAVGEDRCVVVTDRGIVVGLLGRDALTGDDRAAARDVMREGPTTIRAHEDLAGLARRMHNRNVAKILVTDPDGRPLGLLHRSDADAAIDSEAKRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX1</accession>
    <name>A0A7K0JUX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SpoU_sub_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000572">
        <property type="protein sequence ID" value="MST33354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="18640" checksum="77B71F22F9C77DD6" modified="2021-04-07" version="1" fragment="single">MELREVPGGARRGGRGPLPPAGGARVRRGRGGDRGGAPRLIPVDDPDDPRLDAYRELRDAALRRRLEAREGVFVAEGHLAATRLLESAYPVVSLLVAEGKGAALPDLVRAVEERGAPVYVAAPEVLARTVGFDLHRGVVALGRRLPPVPVDAVAAGPGPLLVAEGLNDHENLGALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX6</accession>
    <name>A0A7K0JUX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000715">
        <property type="protein sequence ID" value="MST33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="1">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="25619" checksum="71C12F814EE8975D" modified="2021-04-07" version="1" fragment="single">MRSGTATSRRPSRPPAEGRPVLLTRLYLRNFRVYEDELDLALPPGLVGIYGPNGAGKSTLLEAITFALWGRARTDRSEIRSAGVGGDCVVELEFEHEGHLYAVRRWLTGINSTMKAEALCDGLALAEGATDTKRYVQSVLGMDDGAFRASVFAEQKQLAAFSSQSPAERRRLVLQLLGITPLDGARDTARKDARERDAQLNQLRAVLPDLEVLTVAAADADAAAGAAEAEARAERAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX8</accession>
    <name>A0A7K0JUX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000555">
        <property type="protein sequence ID" value="MST33309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="20802" checksum="1D3BF84FC37041FD" modified="2021-04-07" version="1">MTSPDRLVLASASPARLRLLRAAGIEPEVVVSGVDEEAVTVADPADLVATLARLKAEAVAADARLAGRLVLGCDSTLDVDGVSRGKPADPAEATRRWRELRGRRAVLHTGHHLLDTATGRSAAAVGSTVVRFGHPSDDEIVAYVATGEPLAAAGGFTLEGRGAPFVDGVDGDPGTVIGLSLPLLRSLLAELGHRIVDLWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV10</accession>
    <name>A0A7K0JV10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="184" mass="19764" checksum="5EAA41681346B429" modified="2021-04-07" version="1">MANELDGVRVAFLVANEGVEQAELTEPWKAVEEAGGVPVLLAPEAGKVQAFNHLDKADVFEAGAIRDASPGDYGALVLPGGVANPDQLRTYPEAVRFVQAMSEAGKPFGIICHGPWTVVEADLVRGRTLTSWPSLQTDIRNAGGTWVDEEVKVCTNGPNVIVSSRKPDDLPAFDREIVQRFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV18</accession>
    <name>A0A7K0JV18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000581">
        <property type="protein sequence ID" value="MST33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9636" checksum="C05A93BF2C13C2DC" modified="2021-04-07" version="1">MTVVRIPTQLRPLTAGASEVTVEGRTVAEVLVALEAAHPGFTDRLHDEQGQLRRFVNVFVADEDIRFLDGLETPVLPDSTVSIVPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV30</accession>
    <name>A0A7K0JV30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000729">
        <property type="protein sequence ID" value="MST33793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="21600" checksum="D3E6A4662CADD91B" modified="2021-04-07" version="1">MRRNGLQDGLSIIDEDHRRVREILDELRPEDPGDFPDRKVVEHLIVEESRHEVAEEIWMWPLARDITHAPGLAARGLNQEFHAKRLLSRLRHLPRRTAEANALLERVQYSLREHMLYEEREILPLIRQGMDEELSAQVGELLTAARSAAPTRPRPYLPAWPGLLRASAPIVGRLDRARDLTRRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV62</accession>
    <name>A0A7K0JV62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000750">
        <property type="protein sequence ID" value="MST33857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="26710" checksum="11E2D3CCFF6A3300" modified="2021-04-07" version="1">MPAVHAHDLSKSYGSGHTRVDALKHATFSLGDGEFLALVGPSGSGKTTLLTIVGALLEPTSGEVIIGDRDITRLSGRERTAFRARQIGFVFQSFNLVPFLTARENLTVMSSIARLERAEVNRRADRLLQELDIDARRDNLPEQLSGGERQRVAIGRALVTDPALILVDEPTASLDTTLGSQVVRLLGEEIKKRGKSGIMVTHDSRMADFTDRTITILDGVLTDGEARAGARARRRASGEVAPQSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV83</accession>
    <name>A0A7K0JV83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000582">
        <property type="protein sequence ID" value="MST33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="4">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="90" mass="9560" checksum="014346786C7CC44E" modified="2021-04-07" version="1" fragment="single">MRVPRPLPPPAHFDRAANQRRLVGEEWDVVVVGGGITGCGVALEAVSRGLRTVLVEAGDVASGTSSRSSKLVHGGLRYLSQREFGLVHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ2</accession>
    <name>A0A7K0JVQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000818">
        <property type="protein sequence ID" value="MST34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6401" checksum="28C0262BF8C28E40" modified="2021-04-07" version="1" fragment="single">MGILNRTPDSFYDHGAYWDLDAFYRRAEELVAAGADLLDVGGVKAGAGPEVSEAEELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ7</accession>
    <name>A0A7K0JVZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">GHK86_15485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000858">
        <property type="protein sequence ID" value="MST34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="73"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="32132" checksum="CE36EFF47C0A21B2" modified="2021-04-07" version="1">MPWATGGIAFVPLVGLVFIVVVLLVEALPALRYNGWHFFTHTDFSLGNSYGGIVTSDGVGHPQGADYGILGWIVGTVLSTAIAAVIAVPVSVFAALVIVFKLPRRLSTGIGFVLELLAGIPSVVIGLWGALTLGPFLAAHVYPAISVVVGGTPSRQGLLTSGLVLAMMIVPIVAATTRDLFRTVPSLQRDGATALGLTDWEVVRAVTLPWVSSGIVGAAVLGIARALGETMAVAMVSGVILSGSPSSLFAPITTIAATIVTQLDSALTDSSGFAVRSLAEAALVLAVITLLVNVLARLLVRRVAATGLPVGRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW24</accession>
    <name>A0A7K0JW24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000878">
        <property type="protein sequence ID" value="MST34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="13780" checksum="75C62A61F3FAC09B" modified="2021-04-07" version="1" fragment="single">MNLTVRDARPGDAARIVALLDAGSLQAGREDPTDPAPYLDALAEIDATPGASVLVAEADGEVVGVCQLVTFRHLQHRGGRCAELESLHVDAARRNQGIGTALVDEAARRARDAGCYRLQLTSNQVRADAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA7</accession>
    <name>A0A7K0JWA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000878">
        <property type="protein sequence ID" value="MST34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="220" mass="24294" checksum="0E064CAC59479057" modified="2021-04-07" version="1">MTPPGRLELAWYAFARGVVELFCRVVWRVRIEGREHIPASGPFVLAPVHRSYIDTLICGCLLRRRIRFMGKEELWRSRWSGRFFSSLGGYPVRRGTPDREALRISEDALRAGEPVVLYPEGTRQSGPVVHPLFEGAVFVAARAGVPIVPVGIGGSEWAMPKGSRGIRPVRIAAVVGAPIAPPERSASGRVPRRAVAELSEQLHTELQQLFDEALRNAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA8</accession>
    <name>A0A7K0JWA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000904">
        <property type="protein sequence ID" value="MST34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="473" mass="50216" checksum="C5B87547B803B2E8" modified="2021-04-07" version="1" fragment="single">AYIWTIPVVVVGQLLVSLVFAELGSSYPLAGALYQWSKRLLGPGYGWWVGWFYAWALIITVASVDTGITSYFIDLVNSLFGTDFNAAGPNVILLCTVGLIVLQTLVNVVGVRFTGLIARYGVWVEVLGTFGVVIMLAIAGFHHGFGYLFTTQGVTSARTNPFGVSFSGWFPEAALIAVLANVYIFYGFESAGDIAEEVVDARRRVPRAMVLTMVVGGITSFVLVAGLILASPDGIGAAVKDGVTGIIHANVGSPAVDDITLALICLAFFSCGTSVQAAGARVLFSYSRDEQLPASRTLRAVSPRFKTPVVALLVVGVLPILFALLTRYTPSKPVHIWFVTYPAHVNALFILVSFATSGIYLSFQMVVFAALVARIRGWRPTGFDLGAWAYPVYIVGMVYGVGMLINIIYPSALTSARAALFNYGWMTLAIMVVIAAIGAVYFLLARPHRRSSAAVGGTGAPPTVGAGAGVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL9</accession>
    <name>A0A7K0JWL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000956">
        <property type="protein sequence ID" value="MST34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="205" mass="21129" checksum="AC48A599C056F4DD" modified="2021-04-07" version="1" fragment="single">MRDSIAGASAAAAASGARIVHACGYDAVPSDLAVLLLHTEAAGAGLTDTVLVARARGGLSGGTVDSLRAQLDAVRADPSLRRVLADPYSLSPDPAGEPVVGPQPDAFGPRRDPLLGEWSVPSVMGPFDTRIVRRSNALMGWAYGRDFRYREVMTFGRRPDGAVAAAAVAGGMGGLLAAMRFGPSRWVLDRALPAPGAGPSEAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWN7</accession>
    <name>A0A7K0JWN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000964">
        <property type="protein sequence ID" value="MST34360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="351" mass="37446" checksum="1F0E706D1F806741" modified="2021-04-07" version="1" fragment="single">MFLVLGAVALFALGAAFSGLRAGPHALRTARVLAGPAAVLAGFLVINSFYGYWPTVGALLGHPLPGQVSRRKLAAAIADRVRLPPGGQFGPVMIPAAGAGFVPAESYVWLPPDFNRVPHTHLPVVVTLTGIPGTAQDWARAGGAIDASTAWADTHGGQAPVVVMVNENGRAGHDTECLDSREGQAFRYLTQAVPTWITRVLGIHLAPQRWGLIGFSEGGTCSLLLAVKDHDLYGRFLDIAGDAAPDYGPGGTGTLRVLFDNNRARQAAWNPRLLMATHRYPYLDAWFAAGLQDRGHHLIEPILAADAATAGMHVTTYWAPGHHTWIFARQALQHLYPSFAHTLETGTTTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP8</accession>
    <name>A0A7K0JWP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000971">
        <property type="protein sequence ID" value="MST34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="29236" checksum="48ABF60C95F16B14" modified="2021-04-07" version="1">MSLVSYERADAAAWLTLNRPEKLNALSHELVEELRAALRRAVDDDEVKVVLVRGAGRAFSAGYDLTQEAEGHTTGADAWHRVLSADVTATMELWSLPKPTIAVVRGYCLAGGCELAMACDLVVAADDARFGEPEIRYGSGPVTLLMPFVIGQKKTNELLYTGDLVDAPTAAALGLVNRVVPGEALDDTATELARRIALAPLPVLRLTKLALTRAYEAMGLREAVHANLDLSAILNASESPEQEEFDQLVRTEGLRAALAWRDGRYGERLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR6</accession>
    <name>A0A7K0JWR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DksA C4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000978">
        <property type="protein sequence ID" value="MST34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="17721" checksum="E85207797F75017B" modified="2021-04-07" version="1">MPRAPKTTAATKAAGPAKAPGSTKTAPAKPAVKSDGKATTKKPTKGVKSPFLEAQRESLLAERGNYLRQAEELKAQADSLALEHEPGDVQFDEEGGEGGTSNVDRELDLVLSAQARAAIEEIDRALAKIDAGTYGTCENCGQPIAEARLEAIPYAALCVACKSGGLSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX25</accession>
    <name>A0A7K0JX25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">GHK86_17495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001045">
        <property type="protein sequence ID" value="MST34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="18178" checksum="30FFC40AE062F94B" modified="2021-04-07" version="1">MEIEVVVEIPKGNRNKYEADERGAIWLDRMLFTATRYPADYGYVPGTLAEDGDPMDAMVLLDEPTFPGCHIHARPVGVFLMTDEEGEDAKLLCVPSSDPRTADVTELSHVRSHELAEIAHFFEIYKALEPGKDTEPRGWRGREVAEDRIERARRMYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX61</accession>
    <name>A0A7K0JX61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000862">
        <property type="protein sequence ID" value="MST34129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="18228" checksum="51A21100E92D97B6" modified="2021-04-07" version="1">GDPTDAATTMGPLNNEAVAAKVDAHVAEAVGKGARLLRGGRREADRPTRLYYPPTIVDAVDPAMTIAAEETFGPVVPVVEVASDEEALALTNGSPYGLLASVFTADLERGLRFAEAARTGWVNVNLSTNTWESHLPFGGRSGSISGTGRVGGASVLERFSEWKTILYRMEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX96</accession>
    <name>A0A7K0JX96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GCV_T domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001078">
        <property type="protein sequence ID" value="MST34577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCV_T" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="11619" checksum="3894BBD1663A60E6" modified="2021-04-07" version="1" fragment="single">MAELRHHRLTRDTAEVAGPDAAAYLQGQLSQDVAGLGVGESAWAWLLAPQGKVDALVRVARTGADAFVLDTDPGWGEAVVQRLTRFKLRTRADITAGRLDVLAVRGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF7</accession>
    <name>A0A7K0JXF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001122">
        <property type="protein sequence ID" value="MST34645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="22599" checksum="99A8A256B61188F9" modified="2021-04-07" version="1">MGLRVIGAGVGRTGTESLRQALEQLLGGRCYHMFEIIAGRRDHVPVWLDAARGEYPVWDEFLADYVAAVDWPAASFWPELLAANPDALVLLSVRDVDAWWASASATIFSPRLEEQKARVGFPPDWPDAVLESRFDPQWREEGAAKEAYLRHNDAVRAAVPAGQLLEWAPGDGWEPICDALGVAVPDGPFPHANTSAEFQRLLGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH9</accession>
    <name>A0A7K0JXH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001128">
        <property type="protein sequence ID" value="MST34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="18417" checksum="D83246C8060EF0F2" modified="2021-04-07" version="1">MPDGRVELAVDRGVFAAGRVDPGTLVLLRAVPPPPPAGDLLDLGCGYGPIACTLARRAPGATTWAVDVNRRARELTAANAAALGLTNVRVAGPAEVDPSVRFAGIWSNPPIRIGKDALHELLGTWLPRLAPGGSAWLVVQRHLGADSLAAWLAGRGWSVRRAGSKQGYRVLEVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN7</accession>
    <name>A0A7K0JXN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvN</name>
        <name evidence="10" type="ORF">GHK86_18225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001126">
        <property type="protein sequence ID" value="MST34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="19499" checksum="9A1896B321E884BE" modified="2021-04-07" version="1">MRTPHHHTLTVLVENRSGVLARVSGLFARRGFNIQSLAVAPTDDERFSRITIVVDVRETDPEQITKQLFKLVNVVKITELSPADAVERELLLCTVTADADTRGRVLELVRVFDGGIVDVGWNEISVMLAGEPSKLDDFEDLVRPYGITELQRTGRVALPRVERQAPRLRTTGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS8</accession>
    <name>A0A7K0JXS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001154">
        <property type="protein sequence ID" value="MST34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="10329" checksum="A17B0DE99CEE9393" modified="2021-04-07" version="1" fragment="single">MELRRLRYFCAVAEELHFGRAADRLALAQPGLSQQIKALEAELGTALFVRSSRRVSLTEAGAVLYPEARSLLAAADALEARVRAVAAGGAGRLRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY47</accession>
    <name>A0A7K0JY47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidinol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001229">
        <property type="protein sequence ID" value="MST34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14561" checksum="EC6BE532BD4BD55A" modified="2021-04-07" version="1">AWAAPGGPGGVLHGERRRLQVSGVAELADAHLSGCGSDGWEQIGRPVAARELARRCWRERSFGDFWSHMLVAEGACDIGVDPIVSLWDVAALVPIVEEAGGRLTDLSGVARADGGSAVSTNGRLHDQVLAVVGDAATGKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY87</accession>
    <name>A0A7K0JY87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001295">
        <property type="protein sequence ID" value="MST34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="325"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="530" mass="57021" checksum="1F2C56164A2A7277" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE0</accession>
    <name>A0A7K0JYE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3499 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001063">
        <property type="protein sequence ID" value="MST34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8756" checksum="5FD70AE3B3C6728F" modified="2021-04-07" version="1">MAPTSCARPGCQGSAVAWLTYDYGAQQVWLDDRPGPAGDQWGLCQGHAARLRVPRGWSQVDRRAGAIPPGTDPWEPPAALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYI0</accession>
    <name>A0A7K0JYI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001361">
        <property type="protein sequence ID" value="MST35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="25315" checksum="5660601EFB5ECA6A" modified="2021-04-07" version="1">MDLGLADRTYLVTGGSRGLGYATAAALVEDGANVVLSSRDPAAVAAAAATLGERAVGLALDNADPSTPEVLISTAFERWGRLDGALVSVGGPPPGPATGVGEEQWRQAFESVFLGTLRLATAVGARVGEGGAIALVLSSSVRSPLPNLAISNGLRPGLAMAAKDLADELGPSGVRVFGLLPGRILTDRTRQTVGGDPEALRRAELLVPLRRLGRPEEFGRVAAMLLSPAASYVTGCVVPVDGGMIRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYJ1</accession>
    <name>A0A7K0JYJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosome small subunit-dependent GTPase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001376">
        <property type="protein sequence ID" value="MST35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="55" mass="5442" checksum="839A268ED963E4B5" modified="2021-04-07" version="1" fragment="single">MPAASPDALIAYGWSARVAALFQSAVATGSDRPGRVTRVDRGAVAVVGGAGTEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX8</accession>
    <name>A0A7K0JYX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001193">
        <property type="protein sequence ID" value="MST34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="344" mass="37368" checksum="FCF275B61FFB8883" modified="2021-04-07" version="1" fragment="single">MRVPLNVGDFLRRAVEVCPDLPAVVDEPGVPGSLGTMTYRELDARARGLALSLERMGVGVGERVAIVSPNAARFQTAFFGVSAYGRILVPINYRLNAEEIRYIVEHSGASVLLVDPDSDDALASVKAPHRIVLDGSDDAELFAPAGPGQEPQAWDGGEDDTASINYTSGTTARPKGVQLTHRNCWLNAVTFGWHVGVREQDVFMHTLPMFHCNGWGMPYAVTAMGCKQVVVRKIDGEEILRRVEEHDVTLLCGAPAVVNAILDAASARMARAQYVPGRSVVRIVVAGAPPPSRTIERVEVDLGWEFIQIYGLTETSPLLTINRAPVVWDDNPPLERARLQARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD8</accession>
    <name>A0A7K0JZD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001594">
        <property type="protein sequence ID" value="MST35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="16351" checksum="BE22BC784DF28CEE" modified="2021-04-07" version="1" fragment="single">MMAGREHLHHDDVPATLAILADLLDHRSTLPDGYELTEHGAWVDWEALGRSWLSSTEVAAVHIARGCAIAERHGGLPLSVAGAVREAVEELTGWWAVTPDPDAPDRFGFEAQGFVEPVGLDPYHPDQPGDTDEPGADSRVEQWREGPAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI1</accession>
    <name>A0A7K0JZI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTPase HflX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hflX</name>
        <name evidence="9" type="ORF">GHK86_19950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001344">
        <property type="protein sequence ID" value="MST34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="202"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="321"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="397" mass="43691" checksum="54306ADB6512F571" modified="2021-04-07" version="1" fragment="single">MSLIERSFREKIVLVGVTVPPASDEETERHLDELALLVDTAGADEVARVVQRRDAPDPATYIGKGKAEELRQLSEAVDADTVVFDDELSPAQSRNLEKILGRTAIDRTAVILDIFAQNARTEEGKAQVELAQLRYRLPRLRGRGVGLSQQAGRIGTRGPGETKLEEDRRRLLRRTTKLEAELRRVTATRRLQRKSRRRGRLFSVSLVGYTNAGKSTLLNRLTDAGVLVEDRLFATLDPRTRRLDLPGGESVLLSDTVGFVRKLPHQLVEAFRSTLEVVQESDLLVHLVDSASPDPEAEIDAVRAVLHEIGAAGVPELLAFNKADVTPEAKRLAERHPGSLVLSALTGEGIDDLLQAVGDRLRSALDIVELVVPYEHGDVLAAVHREGEVLVETHDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI5</accession>
    <name>A0A7K0JZI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001689">
        <property type="protein sequence ID" value="MST35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="5">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14235" checksum="01586C4ED150AB5F" modified="2021-04-07" version="1" fragment="single">RVLDGRARRDEILAGLAAELAAAGRPTVTFATVLVGDDEASVRYVGLKHRAAEQIGLAVRGVRLPADVSQAELEAQLSALSADPGVHGILLQLPLPEGGGLDEASASACIAPAKDVDGMTAVSLGRLVLGVPGHRPCTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZJ5</accession>
    <name>A0A7K0JZJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001347">
        <property type="protein sequence ID" value="MST34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="9124" checksum="8EBF791BD6F9FA74" modified="2021-04-07" version="1">MRTTVTLDPDVEEILRARMREQGLSFKEAVNDAIRRSAAGTARAAPFATAPAAMGRSRVNLDRALQLAGALEDDDLLRRMRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZP1</accession>
    <name>A0A7K0JZP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TPP_enzyme_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001646">
        <property type="protein sequence ID" value="MST35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="173" mass="17584" checksum="911B3DA2CE2091CD" modified="2021-04-07" version="1">MPVRDVEWYGAGRAGLTVVANRGANGIDGVLSTALGVAVGSGAPTVALLGDLAFLYDIGALLGAPQRPAQLTVVVVDNDGGGIFSFLPQAAALPAERFERFWGTPHGRDLVALAAAYGVSSRRVEDLGTLRKLLADPAPGVSVAVVPSERAANVAAHERLHAAVAAAVRSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU9</accession>
    <name>A0A7K0JMU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000031">
        <property type="protein sequence ID" value="MST31290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="5999" checksum="3993994AC2D2ADFB" modified="2021-04-07" version="1" fragment="single">MSEPPEPRPPAFPAAAQMRLSRTRLTAVVLVAVALVAASAWTVRRSVGPTPPRPAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN35</accession>
    <name>A0A7K0JN35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000053">
        <property type="protein sequence ID" value="MST31380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="PKS_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_MT" evidence="3">
        <location>
            <begin position="144"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="424" mass="46690" checksum="1296F9F793F8802F" modified="2021-04-07" version="1">MPAPIAPLLARVVGPGLPLAFRACDGSTAGPPDPVATIEVVDRRALNYLATAPGELGLARAYVSGALDLHGDTFATLSLLAREVVGALTWAERLEVLRGLGAGVLRPVPPPPEEVRPGPWWGLRHSLGRDSRAISHHYDVSNRFYEWLLGPTMAYTCAVYPHPEASLEDAQIEKVDLVCRKLDLRPGQRLLDVGCGWGTMVRHAAEHYGASVIGVTLSRQQAEWGQRRLVELGLAGRAEIRFQDYRQVAEGDFDAVSSIGLTEHIGARNLPGYARFLAGKLKARGRLLNHCITRPTTTGPVAHRRGFIERYVFPDGELEGVGTIVTALQDAGLEIRHEENLREHYARTCAAWSANLEAHWDEAVAEVGEGRARVWRLYLAGSRLGFVQRRVELHQVLAVRTERGEAGMPLRAEFPRRPQPVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN38</accession>
    <name>A0A7K0JN38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000054">
        <property type="protein sequence ID" value="MST31382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05257">
        <property type="entry name" value="Arna_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045869">
        <property type="entry name" value="Arna-like_SDR_e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="323" mass="34408" checksum="008AE02D8E489090" modified="2021-04-07" version="1" fragment="single">MDVVAVTGAEGFIGSHLVEALVRRGHRVRAMVLYNMHSSTSWLATLAPELRAEVEVHFGDVRDPATVRALVEGASTVYHLAAIGSVPYSYAAPRSFVDTNTIGTLQVLEAARACETPRIVHTSTSETYGTARTVPIAESHPLQAQSPYAASKVAADKFAESYHLSFGLPVVTLRPFNTYGPRQSTRAVIPQIVTQLASGARTLNLGALDPTRDFLFVEDTAAAFVAVGTAPAAAVAGEVLNAGTGTDISIGDLAATLCRLMGVDADIVEDAARLRPKDSEVRRLVCDAARLTERTGWVPTVPLEAGLERTIAWFSDPANLAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN85</accession>
    <name>A0A7K0JN85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000063">
        <property type="protein sequence ID" value="MST31415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6317" checksum="380C5C5FD00D9504" modified="2021-04-07" version="1">MSEPVAGSSAVADLEQRAGHLGGTFDFDTPPGGGTRLTWRTPLPAPVPGLSPPDPHGAEPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNJ6</accession>
    <name>A0A7K0JNJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybenzoate 3-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.2" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018659">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="398" mass="43237" checksum="8EBE18EE025BA021" modified="2021-04-07" version="1">MERTQVGIIGAGPAGLVLAARLAAAGIDSVVLECRSRRYVEGRVRAGVLEAATVALLGELGVDARLREQGLVHDGVHLQWRGERHRIDFTGLTGSQVTVYGQQEMVCDLIADRLAAGRDLRFEAEVVDADGALGALPGRADGGVVLRYRDAAGAAHELACDVVAGCDGFHGIARRLVPPSALDVYDRGYPYAWLGILADVAPSTDELIYAFHERGFAMHSMRSPTVSRLYLQVDPDEDLAAWPDERIWEELQIRLGVPGWTLTTGPVRDKGITPMRSYVAEPMRHGRLLLAGDAAHIVPPTGAKGLNLAVADVKVLGDALADWYATGSPAGLDAYSSRCLARVWRVQDFSTWMTTLLHVDPKGDPWDRRLQRSRQDEIVRSRALATNLAENYVGLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM2</accession>
    <name>A0A7K0JNM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000099">
        <property type="protein sequence ID" value="MST31570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="20364" checksum="E218AA8EA93273CD" modified="2021-04-07" version="1">GWGRPPAEAPACLDALRAAVLAGEQIDLRYAPPGRPAEDRRLHPHGLVCNRGVWYLVATAPQGMRTYRLSRVVSVRRTGLPAERPAGFDLATAWAAVGERLRERATAVTVEVSVTSQAAGFVRASLERWCRVEAGEGPGRLLVAMPSVPAAARELAAFGDDVVVHGPAEVRAALARTGARLVERYGTPTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNM3</accession>
    <name>A0A7K0JNM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_00365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="373"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="480"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="695" mass="71112" checksum="D4A962BF49AF6AF2" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP1</accession>
    <name>A0A7K0JNP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine cleavage system aminomethyltransferase GcvT</fullName>
            <ecNumber evidence="3">2.1.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvT</name>
        <name evidence="3" type="ORF">GHK86_01820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000073">
        <property type="protein sequence ID" value="MST31471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="12"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="31079" checksum="9D41F846DA605685" modified="2021-04-07" version="1" fragment="single">MSDTALRTTPLDAVHRAAGATMVDFAGWSMPLRYGSETAEHTAVRSAAGVFDLTHMGEIEVTGPDAGAALDHAVVSDLGRLADGRAKYTMLCAPDGGILDDLIVYRLTAEHWLVVANAANAGLVLDELTARAAGFDAVVEDRRDDWALVAVQGPVAATTLARLADRDLAPLRYYTIAPAVVAGADVLLARTGYTGEDGFEVLVRPGDAVGLWERVLEAGKDAAVVPAGLAARDTLRLEAGMPLYGHELSTACTPFDAGLGRVVALDGPADFVGREALAARAAMAPVRRLVGLVAAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU5</accession>
    <name>A0A7K0JNU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000106">
        <property type="protein sequence ID" value="MST31615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="210" mass="22216" checksum="974F2EB79BF100C5" modified="2021-04-07" version="1">MHSVQGDPGGLRERKKISTAAALRGAAVRLTAERGLARVTVEDIAASAGVSTRTFFNYFACKEDALVLPGAGLADRVAEALAARPADEPIVRAVQRSLLGLLDRFDPPPELREDWVLRARLIESHPDSLLPRQLAAYARFEATLATAIAKRTGADVDADVMPGLLAAVVAAAARSAMVRWCHTPDSSLAALLEESLDAVASGFAAIPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW2</accession>
    <name>A0A7K0JNW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_02505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000103">
        <property type="protein sequence ID" value="MST31603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="245"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="467" mass="47644" checksum="751F745DB2262CB5" modified="2021-04-07" version="1">MLVVHGVLLVAVLGTVTVEVVHGFSSHYTHTIVTDLSEEGPEYARAAAQRPAGQTMEAFSRGYLETHVLAGGHLLVVGLRGQAILASAGAGALASRPTVAGWVVAPPLRSELRDVAVGTSRYLVLASPIRTTGGSTVGVLVAAASLAGLAAQRDQVLLLAAGEAVVAVAAGLLSSFLVMRRLLHTVGAVTEAAVAASVGDLGGRLGGAPGEGGAGDEVGRLRAAFDQMRERIAAGLDAQRQLLSDVSHQLRTPLTVARGHLEVLARNPAPERAEMVETTARVIAELEGMSVLVDRLLLLGRSFAPDFVEAAPVALRAFMGDLFAAARVLAERGWALAAVPDVVVVVDGPKLRGALLNLVDNAVKATGTGDGIELGARCATEVAFWVTDTGSGIAAAAQGEVFGRFRRSGSSGRQGTGLGLAIVEAVAEAHGGRVGLHSVEGRGTTVEIVLPGSCLRPGGVGSEDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP03</accession>
    <name>A0A7K0JP03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="300" mass="29643" checksum="8EB9E7CAAB73773E" modified="2021-04-07" version="1" fragment="single">MPGATSSYLPPVIVRVIAQSESFTRSIKKDMALLEAFGKQEANPQVGLNDKRFVSELGATKAELLSFARDVYNARLGADAAPLVAEIARMRAELRTLSPLDIKIDANIAAAEAKIAVLREQLAGLKTDALVGSMLGGMSGAEQLAMNRRVTSMWPVPVGGGDQGGGLGSILSPSLGAFLGLTGAAGIAGSGSILGKMLGGGAGGGLMSGLGFGGTFGLAKFGTLGSLLGFGPEHAIASGIGVGGSLLGAGIGGGLLGLGSMGVMGVGMGTDMAGLGQAAGDIRQTVAAQNALSQAIAVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP06</accession>
    <name>A0A7K0JP06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide modification acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000118">
        <property type="protein sequence ID" value="MST31696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7740" checksum="63EA0B7FE9E66B4B" modified="2021-04-07" version="1" fragment="single">MQQTEATAAPRSRRRPTPYRPGLDGMRAFAVSAVVAYHLAPGVFPGGFLGVDVFFVISGYLITGLLAEEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP68</accession>
    <name>A0A7K0JP68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000117">
        <property type="protein sequence ID" value="MST31687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="11556" checksum="4A03C2E693C5EB63" modified="2021-04-07" version="1" fragment="single">MSPGGGDGASAFAPRLGLLSSALPGAAAGAVCDAASAVRLEGVEWAFGPAEVLRPDDAERVAPEVLRTAAERGLRVCGLAAQPATLLCHDGGEAGRAVELAATLGAPHLRVFAPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPF5</accession>
    <name>A0A7K0JPF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000134">
        <property type="protein sequence ID" value="MST31781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="73"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="3">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="21265" checksum="E093E722932E6E58" modified="2021-04-07" version="1">MPLPARALGEGEEVVVDVRPHGWVLAWPLGMAGLAVVIAAVGAWLRVPRAAAWVLIGLVAVGLAQLLARYARWRATSLVVTTQRVVRRSGIVARRGQEIPLAQISDVSYRQGLFQRLIRAGDVRIEAAGWDAAEVFHAVPRPAAVEREIIRLLAERRAGGGVLSLPEQLARLDDLRRSGVLSPAEFEASKARLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG6</accession>
    <name>A0A7K0JPG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14487" checksum="9A6B9F70F212B49E" modified="2021-04-07" version="1">MDLPAALDRQLRADAGIGHVYYSILAVLSSGPDRTVAPRDLARAAGISLSRLSHALDALQRRGWVARCPTPDPRRQLARLTDAGQQLLDEVAPGHVSEVRRLVFDRLEPSEVRQLAALTAKLLGRPGEQPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ5</accession>
    <name>A0A7K0JPJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000075">
        <property type="protein sequence ID" value="MST31474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="221"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="336" mass="34770" checksum="0C0CC47B02C0CA22" modified="2021-04-07" version="1">MAQAVVEPDGPEQPAPPAASTPATALARSFFSRPSRVAAFLWSAGALAVALVLPLHRWSGPALLGLGVSAAVAACCAGARATVGGRLPRWSVQVDVALGNLLVTVIAAAGASKHTNMANLYLLVEVFALLYLPLRSALVHLGAAGAAYAVVLGLGPRTAEPPAVAWLAVFGTAAVLGAVLVGLVGVLRNIAREDPLTGLANRRSWDEQLQTELERSARSGSALSVVVLDLDGFKAVNDVHGHQAGDRLLQAVARSGQAATRGGGDLLARLGGDEFAVLAPGSDEIGAHRLARRLTEQLPRGVSASVGVATWDRAEGASDLLRRADQALYQAKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP8</accession>
    <name>A0A7K0JPP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="11695" checksum="274318967FBC6C70" modified="2021-04-07" version="1">MPATLKVTHAAIGAEVRRGDYDVVLDGERVGSVEMNRSFELPIDPGHHTLEVRNGRNSSRRRQFDAADGEVVAFRCSGKGRVPVPGVGAVAFLLSFPFPGLALSLHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS7</accession>
    <name>A0A7K0JPS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000098">
        <property type="protein sequence ID" value="MST31569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="239"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="36247" checksum="C3014ADD9550141B" modified="2021-04-07" version="1">MSAGVKSVSDGGNRAFSGRHRPGVAQDAIALCLSGALPGLGDGVLSARELSIASMAVAARSDLWEHLVPQQRDGRWYALLHRSGNYDVWLLGWDPGHETDWHDHGGSSGSFAVARGRLVEQFRRPRTGTAGSRAVRAGGAVTFGPAHVHNVTHGAGAPALSVHVYSPALTAMTYYHLTDYGFSAFETVSVESPHGERSHVADEEQAFTEWDRRAVDDLLASVRRDLQRRPVPREAMEALAAGATLVDIRPAEERALEGEIPGATVIGRNVLEWRLDPQNDHRIPELARYDAEIILVCSDGYASSLAAATLRRLGLARATDLDGGYHAWKAAGLPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS8</accession>
    <name>A0A7K0JPS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000173">
        <property type="protein sequence ID" value="MST31911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="249" mass="26420" checksum="AD80AFA13BDE03FF" modified="2021-04-07" version="1" fragment="single">MRDLVILSMHTSPRAQPGTGDGGGMNVYVRELAAALARSGVRCEVFTRADSPDCAAVVPIEPGFRVHHVPAGPLAPVAKEALPALVGEWADGVGDRLRTLDEQGFHPEAIHANYWLSGVAGHRLKHELDVPLVSTFHTLDRVKAEASPEEIRSAEPARRAQAEAEIVGCSDVILASCSVEAAQLTELYGADPERIEIVAPGVDHAYFGPGDRVQARRAIGMPGDDPLVLFVGRIQPLKGLAVVVEALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ6</accession>
    <name>A0A7K0JPZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsf</name>
        <name evidence="8" type="ORF">GHK86_04715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000199">
        <property type="protein sequence ID" value="MST32028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="7">
        <location>
            <begin position="73"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="269" mass="28459" checksum="3C2CDC03B7CA6DE6" modified="2021-04-07" version="1">MADFTAQDVKALRDATGAGMMDAKRALTENDGDFDAAAKWLRERGLGKAAERSGNANAEGAVAVALSPDGRAAALVELKSETDFGAKSPQFVALVNRLAEQVAAEGEAVAAAQADAIDDLKVTLKENIELGRVVRFAAADGNVLDTYLHVQNDRGVNGVLVELAGADAELAHDVAVHVAFGRPNYLDRDEVPAAEVEAERATAENQTRLEGKPEAALPKIVEGKLTGWFKRVPGGVLLEQPFAKDDKQSVKQYLGKASVVRFAQAVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ20</accession>
    <name>A0A7K0JQ20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="329" mass="35831" checksum="CFB06502DD2D3CA7" modified="2021-04-07" version="1">MTIFSTIWSDDVAYRSQVEVLDWRQLGDRGLFRALGRLRAQDVVIVNGAIGFPGKWRDLASLALRRANERPGVVVADATWEPRSDRAESSAPRLWPLNDRVNRTLLERVAGPRTVACFLSRAEVAWYLADTGRPAGAAAFTPFFASAEPPEGLQRAAHPYVFSGGDSLRDWELLRDALGGLEIPVRVATRHTRGVWPPNFEVGPVPHDEFIALARGATVGVLCLRHDVRRSVGQQTYLNLLRFGVPVVVNDAPGVTDHLADLPGAYVTPAGNADAIRRTVLGLIDQVDRESRPALAARAQAAVAACFSQPAYLGRLISIARSLEIHPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ49</accession>
    <name>A0A7K0JQ49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4868 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032359">
        <property type="entry name" value="DUF4868"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16162">
        <property type="entry name" value="DUF4868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="29898" checksum="5F2ECC3E25995690" modified="2021-04-07" version="1">MPALSGVIQRAAGAYGQCEVIDYQPSGSAGDAETMWLGVDAVPLLSSIVTESADLANLPVFEPTKQSLAALRLAAFRVEKDGVVAVFVQSLRSNQIVARSNKLGVFIRNGVLDVPDGEVLILNSDVSAVLVGGYVFFRNRSQFQQLTGLLDELRKEASTTFATVTKQLRIDGLEYMAAAVTGAPAMLGKMASIQRKLDQYPKYREALTMPKLVAFALDHPECGVEITGEGDDATLVFHNDPQRRFKILKLLDDDYLRSELTTLEYEANSKSPPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ79</accession>
    <name>A0A7K0JQ79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000214">
        <property type="protein sequence ID" value="MST32106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="256" mass="28336" checksum="074DA04B03D649F2" modified="2021-04-07" version="1" fragment="single">YQFVVHLKKAYNPNWFTGNQLTWIYPLPQQAWDKTCATCAVGHNASTPAGALKVFNFLYQSSSAVSTYATNPLWKTVDGPWVMKAYNATTYHTVLAANPRYTGPGKPKLAGYQIYSFSSDTAELDAVRSGTVDFGYIPYSDAGQISYFKSSGYNVEPWSYFYNDAMEFGYTGPWKALVGQLYIRQALQHLVDQPLYIKQTMHGYGLPDYGIAPAYPGSKYVAPALRTNPYPYSVAAATKLLTSHGWAKGANGIDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH9</accession>
    <name>A0A7K0JQH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the trimethylamine methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000226">
        <property type="protein sequence ID" value="MST32157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038601">
        <property type="entry name" value="MttB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010426">
        <property type="entry name" value="MTTB_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06253">
        <property type="entry name" value="MTTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037567">
        <property type="entry name" value="MTTB_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="486" mass="52190" checksum="B266BC603A6C35A2" modified="2021-04-07" version="1">MFVNRMPRWEVLDEGGLQTIEGGWRHLVADIGVRFDHPRAQRLFAAAGQKVEDELVRFDPEFLLEMAALAPPEFGVAARNPARSLVVGGDHMVFAATNGPPFILEGDERREATMADVEKLLMLTQMTDALDTPGRNVVEPNDVPLDVRHLVRSLAAIRLTDRVWSGEVSSASKADDCLRLAEIAHGGRLLVEGEPVLFANVNVNSPLHFDASMLEGLLGYAGAGQAIIVTPFLLMGAMSPVTVAAALAQQTAEALAGVALVQLVRPGTPSVLGSFLSSTDMKSGSPSFGGPESAIGLAASGQIARRLGLPWRSGGGTLTASHGVDYQSGYESFNTQCAAFLAGANVCWQSAGWLEGGLSVSPEKFVADCEVLDLLLHQFSPLQVDEPALAASAYDEVGSAGHFFGVSHTLEHFRDCFWRPTVATTDNYDRWKSRGSATYAERAGRRCEELLESYTAPPLDAGVEDELWAYVEKRAAELGDPVRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI4</accession>
    <name>A0A7K0JQI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="414" mass="42195" checksum="0A4D87A1D121D2C1" modified="2021-04-07" version="1">MPGRRVLIDLAPLRRSRDFRLLIGGQLVSTLGTQLTAVAVPFQVYRLTHSSLDVGLVSLAQLVPLVLCSLYSGAVIDAVDRRRLLLAVELLLAASSAGLALNADLGPALWPLFVAPAATAGLSAFDGPARNTIVPNLVGPADIPTAAAMFQALFQLGSVVGPAVGGLLLAGAGIHFVYWADVVSYGAAVLSVSAISPQRPAAGAPRPGLRSVVEGFAYVRSRQEILGAYVLDVNAMVFGMPRALFPALALTVFKGGPPTLGFLYSSVGAGALVGALTTGWVHRVRHQGVAVTVAVVVWGAAIAGFGAVRSLPVALGLLAVAGWADVISAVFRNTIIQLGVPDRLRGRLQGFQIGVVQGGPRLGDLEAGGVATAFGTEAAIVSGGLLCILGALALGRVLPGFRSVALDPAAPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY8</accession>
    <name>A0A7K0JQY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="17969" checksum="E7E5DB21060476C9" modified="2021-04-07" version="1">MVLGLALVALEAEDLEGGVGPALEVAQPAVGVDGVDGLRRGRQPAVEAAVIQRPGGTGKIPLFHQGQGQVGVKDRVGVAGREARVQGLSGHLLAATEITGDPCTDGGRAAHVGEGSGGPPVPGMSQRSVEDGSGLLLVLGQAEGGQGGHERERRAGPSVQQAVAGQAPPGIVDCFGCTALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR17</accession>
    <name>A0A7K0JR17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000280">
        <property type="protein sequence ID" value="MST32371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="7">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="211" mass="21777" checksum="9FD62F6C97705E06" modified="2021-04-07" version="1" fragment="single">MTDRSAEALAAELRSLAGGPADGVWEGPGRVNLIGEHTDYNGGLALPFALDRSTTVAVRRRPDRRWRCWSHQQSSCGWPPAPVVAELDQLEPAVTQGWARYAFGVAWAVARAGVEVPGADMLVDSTVPVGSGLSSSAALTTAVAVAVDDLTGGHLGAQRLVSVCHEAEAGFVGAPVGTLDQRAALLASPGHALFIDFASDTTETVPLAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR61</accession>
    <name>A0A7K0JR61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YjeF N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000291">
        <property type="protein sequence ID" value="MST32436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="47" mass="4873" checksum="0B91F30B5A9841DC" modified="2021-04-07" version="1" fragment="single">MIPVVTPAEMAEVDRGAPEPVEVLVDRAGAAVARAALRLLGGAYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR69</accession>
    <name>A0A7K0JR69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="29710" checksum="D35D623A319483E1" modified="2021-04-07" version="1">MSRLGLALHYAAKGWPVFPLQVGGKRPLGRLAPKGLHDATADAEQVERWWRQEPKANIGLPTGHAFDVLDVDSPDALERLGEHLPLAEDPTADPFIVGPQAASPRGWHAYIAPTGLGNTVNVGGVAGVDWRGRGGYVVAPGSAKADGGAWTWLCGADDLEYGLDAPILPAPAWLLELRNPTAPKPPSLGASRVPAGVAGDRYVRTALDAECGRVAMAGEGTRNDALNRAAHALGQLVGAGRLDVGEAGDALLRAALLAGLAEAEAVATIRSGLAAGIRSPRAARNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM9</accession>
    <name>A0A7K0JRM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_07620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the trimethylamine methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000336">
        <property type="protein sequence ID" value="MST32590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038601">
        <property type="entry name" value="MttB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010426">
        <property type="entry name" value="MTTB_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06253">
        <property type="entry name" value="MTTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037567">
        <property type="entry name" value="MTTB_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="590" mass="63657" checksum="1903A98933080954" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS7</accession>
    <name>A0A7K0JRS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000350">
        <property type="protein sequence ID" value="MST32640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7184" checksum="460A1825F42F94E7" modified="2021-04-07" version="1">MLVRRIDHVQLAMPAGGEDRARAFYTGLRAAGVAVGEDEPLPGYRRVYVDDPFGNRIELLEPASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS00</accession>
    <name>A0A7K0JS00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000363">
        <property type="protein sequence ID" value="MST32693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="12"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="FAO_M" evidence="5">
        <location>
            <begin position="371"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="429"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="4">
        <location>
            <begin position="728"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="820" mass="87224" checksum="A2FE8BC3B16EFF89" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS02</accession>
    <name>A0A7K0JS02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000367">
        <property type="protein sequence ID" value="MST32715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="341"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="606" mass="65294" checksum="1A0D318C72B004DC" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS48</accession>
    <name>A0A7K0JS48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000382">
        <property type="protein sequence ID" value="MST32762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="4">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="313" mass="32374" checksum="9114E3B6CABCD16B" modified="2021-04-07" version="1">MSGVLVVAEHLQGKLRDPSLEAVTAARELGGPVTVLVIGADPQALVPAVSVEGVDEVLCAAVTAEHFEPDAYLAAVDAAVGARDFDAVLAGFTVNSMGYLPALAAKRTLGFSSDVFSLRRDGDAVVATRAYYGSKVHADVGFPAAPVLLLRPTAWPVAGGTSTPTVATLDVPAGAARVTHVGFEEAPQGDVDITTADFLLSIGRGIGEKDNIETFQKLAEKMGATLSVSRPLVDAGWMPASRQVGQSGKTVKPKVYLAMGISGAVQHLAGMKTAGTIIAVNSDPEAAIFRVAHYGAVVDLFAVAEELERQWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS56</accession>
    <name>A0A7K0JS56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000380">
        <property type="protein sequence ID" value="MST32753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="366" mass="37559" checksum="4EED9C66105C39B8" modified="2021-04-07" version="1" fragment="single">GAPADWPTYGGNPSRSGLAVGTPTFRGHLARRWTAHVDGEVYAQPLVVGGRVIVATENDSVYALAAGSGRLLWRRHLAAPVTTGLPCGDISPSGITGTPVADVTSGRLFVTTFTASGGYHHTLWALSLANGATVWRRPIDVPGSDPRAQQQRSALTLLGGRVYVAYGGLYGDCSDYKGRVAAVAESGRGRLISFTAPVQREAAIWAPPGPVTFGGNLYVATGNGTPARDVADSDSVVRLTAGLRQTGRFTPGNFATLSANDLDLGSTSPAVLPGGLLFQAGKEGTGYLLRAGHLGGTGGQIATVDLGDGAFGGDAVAGHTVFVSCFQQLAAVRLTTGAGRRPALRVVWRAPVPAGPPVLAGGVVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU7</accession>
    <name>A0A7K0JSU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pheA</name>
        <name evidence="12" type="ORF">GHK86_09860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000458">
        <property type="protein sequence ID" value="MST33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="214"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="34588" checksum="13BA921664938976" modified="2021-04-07" version="1">MVVLSCPPMADRVAPDRTVAFLGPSGTFTEEALRTQPDLAAARPLPQRSFAQVLAAVEDGRADFGFVAIENAIEGSVVAALDQLVFERELLIVREVLLPITQHLLAPPGTALADVSRVLSFPVATAQCRAWLGANLAGVEELAATSTSEAVRIVAEERPAGTAAIGTALAGSLYGLEVLAAGIEDHEHNVTRFVLVAPPAAGVPAPTGHDKTSIVCFQSADRPGSLHGILGQFSARDINLVKLESRPTKQALGEYCFIVDFEGHVADEVVADCLRDLHVTLRELKFLGSYPAAGESGPRRRRDARDAWAAADGWIAGIRRTIHDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSV8</accession>
    <name>A0A7K0JSV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000460">
        <property type="protein sequence ID" value="MST33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="14607" checksum="7293E467B91FFDF2" modified="2021-04-07" version="1" fragment="single">MSQRGHVNAGESIEEWVGQVAAGLAGDRGAAEAFAGRVPAGYPQQVGAALAAVDARHLAALEAESSGGPPGAGTAAGLAGASAQRFAVRTEGDAEEFRLRRYGRGAVELSAFLPILESFGLVVVEAVPMAIGPGPDGVGAHIDDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSW6</accession>
    <name>A0A7K0JSW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2891 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000342">
        <property type="protein sequence ID" value="MST32609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021365">
        <property type="entry name" value="DUF2891"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11199">
        <property type="entry name" value="DUF2891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="22124" checksum="A3A871929B7BE425" modified="2021-04-07" version="1" fragment="single">MRAPLERGDRAVLAETIRASVRREYPHVLAQELQGDDGLRPPRELHPAFYGSYDWHSAVHGHWALVRLLAGGLPPDVAAAVEATLDEHLRPDRLARELAFFAGPEGRNAERPYGWSWLLRLHAELEGAGDRRAAATAPLADHLRARLVDYLAATLALPIRSGTHANTAFSLRLLLQVARDAGDAELLDAVTVAARRWFAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX3</accession>
    <name>A0A7K0JSX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PASTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000469">
        <property type="protein sequence ID" value="MST33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="90"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="406" mass="40802" checksum="AA76189DFF393DA9" modified="2021-04-07" version="1">MVAPVGAGAEATAMMAATAAGPTATRVQPAVGGPPRSGRASYVEIEEGTRPPEPPERSRWWLWTLLILVLLAALGVLAYFIGRDLGAFGGSRTASVPQVARETPATARARLGAAGFHHVRQTDVTSDTVPKGRVVGTEPPAGATVATSRTIVLDVSGGRPTVRVPDVTGKTQSAATAQLRHAGFHVKKALQPSSSVHAGVVIQTRPAANSLQTKGITVSLVISSGPRTITVPSLTGQSPTAATTELIQKGFAVNPNDVPVASSSVKSGDVVRTSPPAGRTVPQGTSVTIYVSTGPATVDVPNVINDTRSQAGDALRAKGFAPVFTTIPVSSAAENGVVVQTNPPPGSPQQTGTTITVYLGSYTPPTTPSTTSGTSGTSGTSGTSGTTTTTTGASGTSGTSGSPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSZ2</accession>
    <name>A0A7K0JSZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000474">
        <property type="protein sequence ID" value="MST33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="56" mass="5599" checksum="CEF1848036277A8C" modified="2021-04-07" version="1">MPQAARPAPAVTGVDYLGLVAAAHEEETGTGVKVDFSRMALLGDVNGSDGVDEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT22</accession>
    <name>A0A7K0JT22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000472">
        <property type="protein sequence ID" value="MST33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="231" mass="24258" checksum="DA93367525F5BF17" modified="2021-04-07" version="1" fragment="single">MERRWPSAFDALTGSDPGLNRLRMALEAVAAIGLTIGAEWGFVRLTGALQAPRAARLRPAVAAGDHDLLVTAMLLGSMVALVSSIAVTDPTWRGRLVSLLLVPVPLVASLAFGLALGGHRAVVLTSFAVLLGLGGLARRWGSRGVATGIPLFIGDFIGFFLHGTVRFGAFGWLVAEVAVGTAMCIVVQLALFRPDPAGALRRSQRSWAARARAVARAARSRFELGVAEDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT25</accession>
    <name>A0A7K0JT25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000372">
        <property type="protein sequence ID" value="MST32734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="28257" checksum="C64DA69DF4EE35A4" modified="2021-04-07" version="1" fragment="single">MGAAVDPATGGYWLVTEAGNVYNFHAPWYGSLAGRSLSSPVVAMTATATGYLVTTAAGNVYNFHTPWYGSKAGAALPASVTAITVDPYTGGYWLATTGGNVYNFHAPWYGSAVGKGHADVSGIVGTPTGYLLTTTAGNVYNFHTPFHGSLANRSLTAPITGVTADPAVHGSYWLAAATGAVYPFAAPDYGRAHTRTIAACNGTELLVTAGSTGAVLGHDGDYLSFTNTGSQPCSLTGYPGVAALGANGQQILQATRTPNGHLGGLRPGNTIAPTVILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT55</accession>
    <name>A0A7K0JT55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000489">
        <property type="protein sequence ID" value="MST33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="202"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="809" mass="85395" checksum="88AFF57CBE2C90F2" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT77</accession>
    <name>A0A7K0JT77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4331 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000370">
        <property type="protein sequence ID" value="MST32729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025566">
        <property type="entry name" value="DUF4331"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14224">
        <property type="entry name" value="DUF4331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="485" mass="51383" checksum="36036EBA5E0EF68E" modified="2021-04-07" version="1">MSSHREAPQISKDPVADSTDVYAFVSPWAPSTVTLIANYIPLQLADGGPNFYEFGDDVLYEIHIDQTGDGTPDVSFQFQFTTTTDDPSTFLYNTGPITSLTDSTWNRKQSYTLTRVDHASGATTTLGSGLLCPPCNIGRLSTPDYHALGAAAVHRFSAGGYSGMVFAGQRQEGFYVDLGAVFDLGILRPFEQDHNMFGLKNTGLGRMAAGINSTHFLNVHSLALEVPIEQVTRSGGRPSSVGASDAVIGVWTTASRRASIVNIAGQGKPTETGAYVQVSRLGNPLVNEVLIGLGDKDTWNHLPPSSDKQYLGYFSNPGLAQLLPTLYPGVFPNLAKYNAGKPDRADLVAILLTGLPSGVVPGFQNELAAGGVYADELRLNLAVPPARKPSNLGLIGGDAAGFPNGRRVFDDVATIELRALAGATLPLVDKNYKADAAAGEVSFGLTDGPSDLRAKGTEYYNDGFPVLGMPLSGFEVGPISRVVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT94</accession>
    <name>A0A7K0JT94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000502">
        <property type="protein sequence ID" value="MST33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="16915" checksum="13EC344299C3F5C8" modified="2021-04-07" version="1">MERVVVLGRGGAGKSVLAGRLAAATGLPLVELDAVFWDPDLRPAPPGEWAIRQRQLAAGARWILDGDLGPHDVPRPRLERADTVVVLDLSAAVCAWRAWRRSRERAGFWWWLATWRWRSRPALMAAIRQSAPDAEVHVLRSRAAVEAFLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC2</accession>
    <name>A0A7K0JTC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">UvrABC system protein B</fullName>
            <shortName evidence="7">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 14" type="primary">uvrB</name>
        <name evidence="14" type="ORF">GHK86_10705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7 8">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000511">
        <property type="protein sequence ID" value="MST33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0228">DNA excision</keyword>
    <keyword evidence="3 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="396"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="11">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="596"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="643" mass="73287" checksum="0F7E09DE0CF37956" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC5</accession>
    <name>A0A7K0JTC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000386">
        <property type="protein sequence ID" value="MST32779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="97" mass="10656" checksum="0515C6AFBE0EBB0C" modified="2021-04-07" version="1">MSSPRSRGYRRQLEAGLYATRYERASPREKEYLQVMASLAVGGRARTGQIAAAPGRGLAELSPIRDRLIRKGVVWASAPGELAFSVPGFSEYVSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTC8</accession>
    <name>A0A7K0JTC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IMP dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_10790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="12"/>
    <dbReference type="EMBL" id="WJHE01000522">
        <property type="protein sequence ID" value="MST33205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST33205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="497" mass="54305" checksum="073DF6FD4C46D9B9" modified="2021-04-07" version="1">MARFVPEVSRTFNEFLLLPNRTTADCSPERVDLATGLVRHRPGEPSAIRLSIPYTSAIMQAVSSPELAIALARAGGLSFLHHNQPIEEQAAAVRQVKNFKAGFVVSDTNVAPTDTLRTLRAVMERTGHSTAAVTEDGTAGGRFVGLVTSRDFHPERHNLDSPVRERMIPVESLAVATADVTLSGANTRLWEERLDCLPVLDGQGRLRHLVFRSDYSAHKRFPKEVIDAEKRLLCGAGVNTHDYVERIPALIDAGADILCFDSSDGYNDWQGDALVWAKKHYPDTPIGGGNVVDGEAFTFLAEAGADFVKVGIGGGSICITRDQKGIGRGQASAVIDVAEARDAYREQTGFHVPICSDGGLLHDYHITIALALGADFVMMGRYFARFDQAPGRKIRMGDGYYKEYWGEGSSRARNWQRYDQGEDSLVFEEGVDGFVPYAGDLTHALDLTTAKIRATMASCGAADLPTFREVARLTQVSQQSYEENFASVMLRDATDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF6</accession>
    <name>A0A7K0JTF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000395">
        <property type="protein sequence ID" value="MST32809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="458" mass="49050" checksum="9A6EF8F3F8064219" modified="2021-04-07" version="1">MAIATINPATGETVKTFDESSDEEVEAALALAVETFASYRLTSFAERAGWMRRAADLLDAEVETTAAMMTTEMGKTVASARQEVQKCAKACRFYAEHAERLLTDEPADASAVGARKAYARYQPLGPVLAIMPWNFPLWQAMRFAAPALMAGNVGLLKHASNVPQTALYMQDLFERAGFPRGAFQTLLVGSAKVEGILRDRRVVAATLTGSGPAGSAVASVAGDEIKKTVLELGGSDPFIVMPSADLARAARVAAVARTLNNGQSCIAAKRFIVHEAVADEFEQRFVEAMAALRVGDPMEDGTDIGPLATESQRQDVVELVGDAVAKGARVLCGGEVPGGAGWYYPPTILAGITPEMRVHTEELFGPVATLYRVADIDEAIELANATEFGLGSNAWTQDEEERARFVRDIEAGMVFINGNTTSYPDLPFGGVKTSGYGRELSAHGIREFCNLKTVWVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM1</accession>
    <name>A0A7K0JTM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GuaB3 family IMP dehydrogenase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000548">
        <property type="protein sequence ID" value="MST33292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="387" mass="41325" checksum="E8217D8EA22CCBB5" modified="2021-04-07" version="1">MAEVEIGRGKSGRRAYGFDDIAIVPSRRTRDPEDVDISWEIDAYRFELPLMASAMDGVVSPATAIEIGRLGGVGVLNLEGLWTRYEDPEPLFEEIARLDTDKATARMQQIYQEPIKAELVTQRILEVKEAGVTTCASLTPQRTRQFAQALLDADLDLFVIQGTVVSAEHVSKTSEPLNLKRFIREFDIPVIVGGCASYQAALHLMRTGAVGVLVGVGPGHACTTRGVLGIGVPQATAIADARAARAQHLDETGVYVHVIADGGMGTGGDIAKAIVCGADAVMIGSPLAAAREAPGKGYHWGMATFHPTLPRGARVRTATRGTLQEILVGPAHENDGRLNLFGALRTSMATCGYESVKEFQKAEVMVAPALLTEGKDLQRSQGVGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ5</accession>
    <name>A0A7K0JTQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000560">
        <property type="protein sequence ID" value="MST33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="73"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="21548" checksum="895355CD9A985036" modified="2021-04-07" version="1">MKAASALLGRPLQAVARFDRHADGLVAEHLRGRRSVDAVMYAASALGDHGVLWMLLAGGQAARLRERDWKRPLLRAVVGLGVESAVVNGPVKWMFRRARPVHEGPRPLYLRTPRSSSFPSGHASAAFFGAALLRDDDPLWPLYYVVAVVVATSRLHVRIHHASDVIAGAAVGIALGELARALVPLDPSRGPRDGDRVGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW9</accession>
    <name>A0A7K0JTW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000578">
        <property type="protein sequence ID" value="MST33387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="637" mass="68072" checksum="529ECDFEB30C6CB7" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU07</accession>
    <name>A0A7K0JU07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000591">
        <property type="protein sequence ID" value="MST33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="13613" checksum="5A63D8208AD6DD4B" modified="2021-04-07" version="1">MEQRISLITLGVSDLGRARRFYESLGWTGARQPDDEVCFFQAGGMVFGLWTALGGHGAPGIELAHNVRSPEEVGTVLEEAARSGGSIVRPAAVADWGGTSGAFADPDGYVWEVAHNPGWTIAGDGSIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU25</accession>
    <name>A0A7K0JU25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000481">
        <property type="protein sequence ID" value="MST33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="344"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="485"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="746" mass="81327" checksum="7023667DC3F6A782" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU34</accession>
    <name>A0A7K0JU34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ORF">GHK86_09945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000464">
        <property type="protein sequence ID" value="MST33039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="7643" checksum="C72A761C7EEBF098" modified="2021-04-07" version="1">MLTAVIIAVHVIVSAALIFLVLLHSGKGGGLSEMFGGSLGSAAAGSTVAERNLDRATVACAVAFAFTTTILAIRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU41</accession>
    <name>A0A7K0JU41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">GHK86_12140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000605">
        <property type="protein sequence ID" value="MST33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="8"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="197"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="439" mass="50256" checksum="12F09E8001462558" modified="2021-04-07" version="1">MAAPDLEDIVRLCKQRGFVFPSAEIYGGFRSTYDYGPLGVLMLRNVKQAWWRSMVQLRHDVVGLDAAVLSSPRIWEASGHLANFTDPLVDCRNCKERWRADHLEPGDDGVVHCPNCGSTDLTEARAFNMMFKTHVGPVEEEGSEAYLRPETAQGHFVNFLNVLQSSRKRPPFGIAQIGKSFRNEITPGNFVFRTREFEQMELEFFVPPAEADRWFEYWCHERLEWYVDLGIPRDLLRLRHHDKEELSHYSSGTADVEFRFPWGWGELEGIANRSDYDLRAHSEASGTRLEYFEQASGERYTPWVIEPAAGATRTMMAFLIAAWDSDEVGGESRSLLRLHPRIAPYQVAVLPLSRKETLVPVAHEVLGLLQPLVMCDYDETQSIGRRYRRQDEIGTPLCVTVDFDSLEDRGVTIRDRDTTEQVRVPIDALVTEITSRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU90</accession>
    <name>A0A7K0JU90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fae domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000623">
        <property type="protein sequence ID" value="MST33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014826">
        <property type="entry name" value="HCHO-activating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037075">
        <property type="entry name" value="HCHO-activating_enzyme_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08714">
        <property type="entry name" value="Fae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fae" evidence="1">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="18428" checksum="032506C9A4EAC52F" modified="2021-04-07" version="1">MNPAARTDVDGRIAQGWGGTSPNGVHVNVILARRGSPTAAAMITAFAAPSPGFCPIGVPVGPDQPSYETVNPPVILLNKVPVDGFAETLVFGAATVGTAQGVLDCVADELLEADQETVVFVALWVDPAADDETAVKHAARQAVGAATREAICGRDRVAARRLVDERDTLTHPFYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV02</accession>
    <name>A0A7K0JV02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000716">
        <property type="protein sequence ID" value="MST33763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="8598" checksum="FEE3CE0EC588794A" modified="2021-04-07" version="1" fragment="single">MKGSPRDDGTAGPRLPPGFAALVGRAGIRSGPGDDVVALWATQAASSAAVFTRSRFAGPSVTLSRAHAAGGRARGVVVVAGNANVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV06</accession>
    <name>A0A7K0JV06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000699">
        <property type="protein sequence ID" value="MST33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9799" checksum="611534E8F9564212" modified="2021-04-07" version="1" fragment="single">MELTELDHVAIAVRDLDAAVRWYEEAFGARVAHREVVDHDGVEEALLAVADSYVQLLTPTRPDSPVARFLDSRGEGLHHVGYRVEDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV28</accession>
    <name>A0A7K0JV28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000732">
        <property type="protein sequence ID" value="MST33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8844" checksum="FA1C7527DDC3FA8F" modified="2021-04-07" version="1" fragment="single">MTSRPLVVYADGPDGPLPDPRSVAAIRKLADPELLLGWVVRTPAWLDEIGLPVTTVLAGSGLRAAVRAGRVRHVPRRLSAMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV43</accession>
    <name>A0A7K0JV43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="10" type="ORF">GHK86_14020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000739">
        <property type="protein sequence ID" value="MST33830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="131"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="426" mass="45931" checksum="EB74CB58475585A4" modified="2021-04-07" version="1">MRYWVETLGCPKNQVDSDKLTGSLASGGLSPAPAPEDADVVVVNTCAFIEAARQESIDTILELAERRRPGSRLVVTGCMAERYGAELAAALPEVDHVAGFGEDLLATPVSLGPTRGGKVPAFDLLELPRPPSAAPWAYLKVAEGCDRRCGFCAIPSFRGRQRSRRLDDLLAEVDALAAREVVLVAQDLASYGRDLGQRGAIGPLVEAVAARVDRVRLLYLYPSQLTDGLIEVIGATGCAYFDLSLQHVSRPHLARMRRWGSGERFLERIGRIRARWAEAAFRSSFIVGYPGETEEDHDRLLAWLADAELDWAGFFPYSREDGTYAADLPDQVPAGLVAERLAECSELQDAITARRRRALVGTGARVLVDAPGVARSHREAPEIDGVVRVPADLPPGTWQDVVITAAEGPDLDAAVAAAPAMGMGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV55</accession>
    <name>A0A7K0JV55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Error-prone DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_13730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-C family. DnaE2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000721">
        <property type="protein sequence ID" value="MST33772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_alpha" evidence="11">
        <location>
            <begin position="36"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_finger" evidence="12">
        <location>
            <begin position="286"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="523" mass="57458" checksum="8FDBA1315F522EF3" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV67</accession>
    <name>A0A7K0JV67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000740">
        <property type="protein sequence ID" value="MST33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="286" mass="30377" checksum="58D63ADD1F1DDD9A" modified="2021-04-07" version="1">MAAPALTPTMSPAQLGRARRTSRAVTAALVVLLFLVPVLYVVMLSFESAGHFLRSPMTPPVSAPRPGNFGAAWAQAGLGVELANTALYSVVAAGLATALALLIAFPIARRLVRGASLLYSAVAVGLFLPLAIIPLFIEARMLDLWNNRIGYIILHIEPGIPLGVVLLTASIASVPLELDEAAFMDGAGYLRYLWSVVVPLIRPGLLITFLYGLLGVWNDIIGPVVLLSNPSLFPITRGIYEFYGANQSQWTLLAAAIVVASLPLVILFSLTQRQLIRAAVAGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC5</accession>
    <name>A0A7K0JVC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-type cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000770">
        <property type="protein sequence ID" value="MST33915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="166"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="285" mass="29624" checksum="F3F4908C5DDF0A6F" modified="2021-04-07" version="1">MSRLIAASRAGLGRRRRLLAGPVAVLAIGLVSFGFFAGFSGTSSATQPIVTQQKSVLEEGQYLFDEHCSSCHGAAGVGSTRAPSLIHAGAAAADFYLVTGRMPLNAAGQQAMQHTPFFNSHEIEALVSYVADLPRIHSTFPGPAIPSILPLCSANTKAAAANPNCVTLSYGQQTYALNCAQCHQIGGAGGILANGMIVPSLKSAPPLVVAEAMRVGPQPMPRFGTGQLDEKQLSAVVHYVQYLHSPENRGGLPISGFGPVAEGFVGILVGFGLLLFVARMIGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ1</accession>
    <name>A0A7K0JVJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000793">
        <property type="protein sequence ID" value="MST33968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="9298" checksum="09801D91B17BDC44" modified="2021-04-07" version="1">MASTPQRSVEELAARLERRQLLPPPAKRRLIRRRAGASQQDIAAAVGVHRETVSRWERGERSPRGVHVDAYLAVLTRLEEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK6</accession>
    <name>A0A7K0JVK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000790">
        <property type="protein sequence ID" value="MST33961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="472" mass="50662" checksum="382B27C024255E40" modified="2021-04-07" version="1">MTDPLCYLSATEAITRFRAGEVSPVELVQAVIDRAEEVEPTINAFAETFPDAALAAAREAEARYRQGTARPLEGIPVAVKEEAPIAGQRNTLGSLALRDEVADETAVFVQRILDAGGIVHARTTTPEFSSAPFTWSRLWGVTRNPWNPAFSPGGSSGGSAASLAAGSTTLATGSDIGGSIRIPASFCGVVGFKPPYGRVPEGPIFNLDHYCHEGPLARTVDDCRLLENVIAGPHPSDIVSLRPKLVLPEAFPPLDGARIALSLRLGDYRVDPDVLANTRAAADRLRKAGATVEEVELPWRREDLLRAARIHFGMIFGASIAELYATRGDELTSYARRLYEESEAVPKSELVPGLALEGRLYHPLGELLEDFDALVCPTFAVPALPAEWDTGDPLDVGGEALDDWLEVMMTIPFNIFSRCPVMSVPSGRSRDGVPTGLSIVGPTYDDVAVFRVAAALEAVEPWLATPDDRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM3</accession>
    <name>A0A7K0JVM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000646">
        <property type="protein sequence ID" value="MST33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="18164" checksum="35471AD7A638C9C0" modified="2021-04-07" version="1">MAEPPVPSVPQVQRAFREELHPARRSAVISWLAFGTTFGTVRAITYSIRDGRGPLHDLTPGGMHLHHYLWGIALVSGVGGVALRGEDRTRRHPVVATAYGVGMALIVDEFALLLDLRDVYWAKEGRWSVDLGVGVTALAGAALEGRPVLRRLRQEMRSRRHGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ7</accession>
    <name>A0A7K0JVQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">argR</name>
        <name evidence="12" type="ORF">GHK86_15040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000819">
        <property type="protein sequence ID" value="MST34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="10">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="11">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16445" checksum="0887518DAFB44CCA" modified="2021-04-07" version="1">MRLSKAARQHRISQILEREAVGSQQQLVELLAEAGVEATQATVSRDLEELGALKVRAAGGEAVYAVPELPHDRAVPSDHLRRVLGEWVVEVASSGNLVVVRTPPGSAHVVASALDRTPLPQILGTVAGDDTLVVIAAEGVSGAEVGRQLGELAGLAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA3</accession>
    <name>A0A7K0JWA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000903">
        <property type="protein sequence ID" value="MST34227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="72" mass="7471" checksum="2506016B2FDF34CF" modified="2021-04-07" version="1">MLPGALWDAALARLDAEGLEPWDRDAELVPAELCSDVVTGDGRRGPEALLQPTCPVAPELLRPTAGGAGPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB5</accession>
    <name>A0A7K0JWB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">4Fe-4S Wbl-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_16120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000910">
        <property type="protein sequence ID" value="MST34241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST34241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="11631" checksum="102A74B0339161BC" modified="2021-04-07" version="1">MFASEALEGLQDQQVDWDEALCRDESGTMTLLFFSDEIPDIRRAKTICLDCQLVDPCLAGAIERREPAGVWGGELFANGRILTQKRKRGRPPKNRPVEGIQLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC3</accession>
    <name>A0A7K0JWC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000916">
        <property type="protein sequence ID" value="MST34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="389" mass="40870" checksum="2BAF26094EBD7948" modified="2021-04-07" version="1">ASVSESATLAIDAKAKALVAAGEDVIGFGAGEPDFPTPASIVEAAVEACRDPRNHKYSPAAGLPELREAIAAKTGRDSGYQVTAGQVLVTNGGKQAVEEACATLLDPGDEVLLPAPYWTTYPECIRLAGASVVEVPTTGASGFKVTVEQLEAATTGRTKLLLFVSPSNPTGAVYRPEEAREIGRWAAERGIWVLTDEIYEHLVYGDAVFSSLPALVPELADTCVIVNGVAKTYAMTGWRVGWIIGPADVVKAASNLQSHATSNVCNVAQRAALAAVSGPLDAVAEMRAVYDRRRRTIVSMLREIRGVECAEPEGAFYAFPSFEGVLGRPVGSRTPQTTLELAEIVLDEAKVAFVPGEAFGAPGYGRFSYALGDDAMVEGVTRVGKLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD6</accession>
    <name>A0A7K0JWD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000918">
        <property type="protein sequence ID" value="MST34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="487" mass="51248" checksum="EE6AF0CC8FB90E19" modified="2021-04-07" version="1">MSIVLQGGRVVDPAAGTDTVADVLVEDGRVAAVGAGLDGDVAVDVTGLVVGPGFVDVHSHADSVAGHRVKAMDGVTTTLELEAGRLPVADAYGRAAADGRPLNFGFSASWAVARAVAHLGPAWAGALPLGVLGDPGWQRSSTPAERRGWLRLLQEQVEDGALGIGVLLGYAPGSDPSEFVALARLAAEAGVGVFTHTREPREIDPSGPVDGPGELVLAAATTGVRMHQCHVNSTALRHIDRVLADLERARAAGSTVTVEAYPYGAGSTAVGAVFLDPDYLQARGTRPDQIVLLPSGERVADAHRLREVRATDPAMLCVIEYLDESDPADRALLERSLVHPDAIVASDSMPVVWPDGSTDAGAWPLPPGGLTHPRTAGTYGRALRRLVRETGRWDWVEAFRRCSYLPARLLDFAPGARRKGYLAPGADADLVVLDPLTISDAATYRDPLRPSTGVRHLLVNGTFVVRDGELDPAAHPGRPLRGEPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD9</accession>
    <name>A0A7K0JWD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ORF">GHK86_14245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000757">
        <property type="protein sequence ID" value="MST33874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="70" mass="7952" checksum="7A50E9DE33D6700E" modified="2021-04-07" version="1">MKTEIHPEYQTATVTCSCGNTFTTRSTKSSLTTELCNACHPFYTGKQKLVDTGGRVERFERRYGRRGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE3</accession>
    <name>A0A7K0JWE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trpD</name>
        <name evidence="5" type="ORF">GHK86_16295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000926">
        <property type="protein sequence ID" value="MST34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="4">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="3">
        <location>
            <begin position="91"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="313" mass="31492" checksum="F7687078703C71CC" modified="2021-04-07" version="1" fragment="single">MGHPSGAPTLEDLGGWPGVLGRLARREDLSAVEAGVALAVILAGEATDAQIAGFVFGLRCKGETVEEMRGLVQAMLAAAEPVELPEELRARLVDTCGTGGDRSGTINVSTIAALVVAGAGVPVCKHGGRAASSHAGSADVLEALGVAIGLGPAGVARCIEEAGMGFCFAPRYHAAMRHAIPVRAQLGVPTAFNFVGPLANPARVRRQVVGVGDPRMAPTMAGVLAGNGATHLAVVHGADGLDELSTTGVSTLRTLEGEQAVDPRALGFEPATLAQLRGGDAAANAAAAVRILDGDAGPQRDVVVLNAADHQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH7</accession>
    <name>A0A7K0JWH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000934">
        <property type="protein sequence ID" value="MST34298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="382" mass="39549" checksum="3AC60694F923E0D5" modified="2021-04-07" version="1">TQGTRLPLPVAGADAEIVRRLRAAGGIPIGVTNVPELCIQPWTASDANGVTRNPWDPSRTPGGSSGGSAAAVAAGLVPFATGSDGGGSIRIPAACCGLVGMKPSRGRVSSQPFGEMWMGLSTYGTLARTVADSALLLDVTSGATAADEERVADPGTPFSEASHRLPARLRVAVSRKVPPGVRAALSPDQANALDRVTRLLAGAGHRLVERDPDYGAAGLEFTALMLAGIHADYQRLGGRPDLVERHTRQLAAAGRTAVPPRLRSWLKQRRHRSAARLATLWSDVDVLLTPCLSRTALPAEGGYGRGAIRAFDLASRFTPYTPAWNLTGQPALAVPAGIAADGLPTSVQLVGRHGSEGLLYALAGELEALAPFAGDVPALAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW5</accession>
    <name>A0A7K0JWW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_17075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001001">
        <property type="protein sequence ID" value="MST34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="20382" checksum="0E47BEDAFBA89879" modified="2021-04-07" version="1" fragment="single">MPLSDAMFLVPERREQPMHVGALQIFELPEGAGADWVAALYARWLEATEVRALFRRRPERSLRTLGAWNWTLDDDVDLEHHVRLSALPRPGRVRELLALVSRLHGTPIDRQRPLWELHLVEGLEGGRFALYSKLHHALLDGAAGMRLLGEVLATEPTVPVPPLWAPRPGPTRERAPGDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX42</accession>
    <name>A0A7K0JX42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000854">
        <property type="protein sequence ID" value="MST34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="15415" checksum="875A6CA2E2CDF7A0" modified="2021-04-07" version="1">MEAGREASLRDDRRIDGADPMHAAAGLDGAVERVLHAVATVDRVAEDPGDDVGRSPAVDEARQALHGALVTLTRPPATRRAGARDGDPSDPTGEDALGMVDDVMRRLLVAAVAAHDAAGAAGDGVEEVIAQIDGAIRALRVGALTGAFPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA9</accession>
    <name>A0A7K0JXA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c-type biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_17900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Possible subunit of a heme lyase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CcmH/CycL/Ccl2/NrfF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001085">
        <property type="protein sequence ID" value="MST34587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005616">
        <property type="entry name" value="CcmH/CycL/Ccl2/NrfF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038297">
        <property type="entry name" value="CcmH/CycL/NrfF/Ccl2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03918">
        <property type="entry name" value="CcmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="24568" checksum="C7AA3DA4C3688082" modified="2021-04-07" version="1">MAGHPGPGGDRHLRRDRHPHGVPRGPRRHHRRLLPVGDLADQPRLAHHQRHPRLRWERGLGRVSGTGRRALTRWVPWVAVVAVAAVALVLGSRQPPAHLTLQQRTEALASQVRCPVCVGETVAESSAAPAIAIRHEIRRDLAAGEKPSAVLASIEAAYGPSILEKPQATGIGLLLWVLPVLAAIAGLVGLAAAFVWWNRRRIGPPATEADHLLVAGMLGSLDHPTGEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXB9</accession>
    <name>A0A7K0JXB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001092">
        <property type="protein sequence ID" value="MST34601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10321" checksum="F56B421579C33290" modified="2021-04-07" version="1">EVHLSTIYRNLEELQKLGVIVHPHLGHGPATYHLATAAHAHFVCERCGATLEAPRSVFRELAAAALAEHGFEVNPFHFAVPGLCASCRAAAGDAPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK2</accession>
    <name>A0A7K0JXK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-ACP desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001146">
        <property type="protein sequence ID" value="MST34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="316" mass="34997" checksum="FE85536877799CCD" modified="2021-04-07" version="1" fragment="single">MASELPELPEAIEGAATRLLERHLDRTKEWFPHELVPWARGRDFEPGEAWRPDEPLAPGVQSALWVGLLTEDNLPHYFHALASTFPPESAMGEWTRRWAAEEGRHAIVIRDWVSVTRSLDPVALERARMRQVTSGFDQASRNETIADAVVYVALQELATRIAHWNTGRHLDATGAAVMRRVAADENLHFLFYRDMATVLLEVDPSAAMLAIDRQVTSFAMPGAGIAEFARHASLIAASGIYDVAVHYEQILLPVVLRHWRVEAVEGLSPEAEQARQHLLRHVARVRRVAERLRAASGADPASNPCAAPGAGAGTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR4</accession>
    <name>A0A7K0JXR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001197">
        <property type="protein sequence ID" value="MST34755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="183"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="264"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="486" mass="52489" checksum="B0CA2FD395C0232C" modified="2021-04-07" version="1">MLAGGLVVSGLFVRIAADERALLLQRLDPSLAELQAYQSDLVGASVGAREYFLDGDPRALALYRSDLSDSRRASRALQAELPGGDISGDDLGRTESAARAWERTLRTEVSPHPPAGLALLARGTTQFARVRADLARVLADVDSRRRAAVAGFDRSLLVLEIVVAAVFAAAIALLVALRAGVRRGVLTPLTIVGTDARRVTEGALEHPVRPAGPAEVAELADAIDEMRRRVVHDLRELERAHADLAARSEELVRSNRDLAQFAAAASHDLQEPLRKVAAFCQLLEERYSAQLDDRGRQYVAYAADGAKRMQALVRDLLHFSLVGGSHHEWSVVDLDACLREAETNLGRRLEDSGARVVRCTPLPAVPGNGPLLVALWQNLVDNAVKFRSDEPPVVEVAASRDGDDWRLEVADNGIGIDAAHAERIFDVFTRLHTRERYEGTGIGLAMCRRIVELHGGSIGVQAGREHGTTIRFTLPAERGGGASSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT5</accession>
    <name>A0A7K0JXT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PspC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_18785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001199">
        <property type="protein sequence ID" value="MST34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="65" mass="6796" checksum="ED98A39C8D6035D7" modified="2021-04-07" version="1">MVAGVAAGLAEYLDVDPLLVRIAFVILTATGGLAVPLYAALWLLVPADEAPTSIAEDLLGRYAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW0</accession>
    <name>A0A7K0JXW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001222">
        <property type="protein sequence ID" value="MST34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="27047" checksum="1459A4CEA0481230" modified="2021-04-07" version="1">MHRALRAGSALPGAAGRGAVHGAQAPRPPGRAAAVPRGEPRPQPHRQPGAPPPAPRAARGLVRWVARAGRWGTAGLIPGRRPAATARIRPFRRSPGGVRICGVTTTPVTSWADVASRLASSRNYWLATVDEDGAPHTVPVWGAVVDDALHLYTSRTSAKAHHLARNPRVALHLESAEDVVIVDGRLEDLGHPSEHPEVLRALEAKYPDDTDYLPSHDPFYDALFRLQPTSAKLWLLADFDGSQRRWRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY25</accession>
    <name>A0A7K0JY25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000999">
        <property type="protein sequence ID" value="MST34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="26384" checksum="AF00B5EBD5C6D4F2" modified="2021-04-07" version="1">MTGRLEGKVAVITGAASGIGAASAVRFSDEGAKVVVADVDARAGQALADRIGGSYFEVDVTDAAGVEAMYDHALQRWGRLDVSFNNAGISPPEDDSILTTGLDAWRRVQEVNLTSVYLCCQAALPRLLAGGGGSIINTASFVALMGAATSQISYTASKGGVLALSRELGVQFAREGVRVNALCPGPVSTPLLQELFANDPERAARRLVHVPMGRFGQPEEIAAAAAFLASDDASFITASTFVVDGGIHAAYVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY27</accession>
    <name>A0A7K0JY27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001253">
        <property type="protein sequence ID" value="MST34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="102"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="24569" checksum="F17E435771284474" modified="2021-04-07" version="1">MTTNVPTSADHTPRVAILRQELLPHVQDVPRHSPPLNATRVFATTGGMTAAALELVRAAVTAEGVDRRLREILRRTAWIFRERTQGIHRPTLSTAASQALTEAPKLTEDAALRLSVARGDGNRESEVRAAHQLLVSLPLADPDDPSRRSKRCADAHLAFHTKPIACCGDEALHDTRRRRSDPAELYNAWSGHTEQGAERVIATAHRELMEAALARDADPTSPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY33</accession>
    <name>A0A7K0JY33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001270">
        <property type="protein sequence ID" value="MST34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="86" mass="9173" checksum="4B5803656028BE61" modified="2021-04-07" version="1">RTIAPGIGEVKRMYVVPSWRGRGIGPRLLAALEAHAAGLGLAATRLDTGPKQAGAQRIYERAGYRPIGNYNANSHASFWGEKSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY78</accession>
    <name>A0A7K0JY78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001286">
        <property type="protein sequence ID" value="MST34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase NYN" evidence="1">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="201" mass="21480" checksum="890649C48BA68461" modified="2021-04-07" version="1" fragment="single">MVDYNTVMSPRHVVVDGSNIATEGHNLPSLAQLDQAVREFLAENPDDVVTVVVDASFGHRIDPSELKTFEEAEAAAEVVSPPAGAIGRGDAFLLRIAEKTGATVLSNDSFQEFHGEHEWLFEKGRLIGGKPVPGVGWIFTPRTPVRGPKSREAVKEAKRRRRGAEVAEGVTGLDLAASRGGRGKRVERAIATATVEATGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY94</accession>
    <name>A0A7K0JY94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001311">
        <property type="protein sequence ID" value="MST34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="168"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="285" mass="30070" checksum="F993735C06C392EE" modified="2021-04-07" version="1">MRAAEPARSGLPSWDIAVPSEPSRLPGVLMAGFSDRANDLAEVALVPHPAVTVLFDLGDNPLVVEDSAGRRQRARIVAGLAPGGVRGRGLAGSMECLQVRLSPLAAHAALGASAELGGTVAALDDVWGRDAERTQERLRAAGSWEERFAVAETALARRLDAGRVVDPEVAFVWQQMVVARGRVRVERLASEVGWSRKRLWTRFRSQIGLTPKRAAQLVRFDHAAHRLAAGQSAASVAADGGYVDQSHLHRDVVAFAGVTPAAVAGAPFLAVDEVAWAAGSTAFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYE1</accession>
    <name>A0A7K0JYE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.101</ecNumber>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_19910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="7"/>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001339">
        <property type="protein sequence ID" value="MST34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="18277" checksum="A3E187E76B2A7EB2" modified="2021-04-07" version="1" fragment="single">TTLRAPAVERPPFAVASVTLPLMDGSRPVPTIVRYPAVRVHGTLIPARKAAPFPLIVFSGGWKVGPSAYSDLLGAWTAAGYVVAFPEYPGTLPGEKTPGEGDIANHPGDLLAVLTALHHASGPLDGLIDQARLGLAGHSDGGDVTDAVVANSCCHIAGVTAAVILSGAELDSWRGAYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG3</accession>
    <name>A0A7K0JYG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001357">
        <property type="protein sequence ID" value="MST35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="41" mass="3737" checksum="91FC8AFC1D5A09EF" modified="2021-04-07" version="1" fragment="single">MVVVGAGIAGASVAAHLAAEGAAVVVIDADRPGRATHAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYM0</accession>
    <name>A0A7K0JYM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_18160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001119">
        <property type="protein sequence ID" value="MST34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="25532" checksum="4176615972CF36B6" modified="2021-04-07" version="1">MASTVLLVEDEYKLRELVRSYLEHEGLVVLSTGSGAEAISFAERAAVSLVVLDLGLPDIPGEEVARELRARSDVPIVMLTAKSEERDRIAGLQLGADDYVTKPFSPKELVLRVQAVLRRGRSERVEAGPVSFGGGELVIDEERREVTVRGAVVGLTPTEWGLLAALASAPGRVYSRLELVNRIRGYEFEGYERTIDSHVKNLRRKIETDPASPRLVQTVLGGGYRLGLRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW9</accession>
    <name>A0A7K0JYW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPF/RaiA family ribosome-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001476">
        <property type="protein sequence ID" value="MST35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="1">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="1">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="26416" checksum="68B80C8378BD6A37" modified="2021-04-07" version="1">DYALQRIGHVIQRMDEPVLAARVTLSLAADPARTRPALAKANLDLGGRFVGAHVAAHGVPEAVDLLSDQLAQRLADRAQRLEALHRRPVGSEGPGEWRHGDLPATRPEYFDRPADERELVRQKAFVTAEQSVDEAAFDMDQLDYDFYLFRDVVTGDDSLLERRSGGVYRLQGVRPRAAAPGPTAVELDVDGRPAPVLTLDGAVEQLAEADGRFVFFADAVSGRGCVVYRRYDGHYGLLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ46</accession>
    <name>A0A7K0JZ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001245">
        <property type="protein sequence ID" value="MST34834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="55" mass="5325" checksum="7A6672E12EEF1A8A" modified="2021-04-07" version="1" fragment="single">MSEREPTEGPTVATAQGAGGMSRRRMIAGSAVVGTAAWLAPAVEALATPAAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ68</accession>
    <name>A0A7K0JZ68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001512">
        <property type="protein sequence ID" value="MST35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_11" evidence="1">
        <location>
            <begin position="38"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16198" checksum="2D8AD3F8BDEDD401" modified="2021-04-07" version="1">HRHPASGGHVPDGVHHLPGPVLTSLSSSVRRVGDDPAAAATVKLLGNYLLLGGLAMLAEAVAAGQSAGLPDDVLVGFFEAVAAPSLRNRVADIVRGDHDGWFPTPMGAKDVHLLNDTAEAAGLRLPVAALVASRYDEAAAAGLADRDVAAVVELLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ74</accession>
    <name>A0A7K0JZ74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="10" type="ORF">GHK86_21210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01001542">
        <property type="protein sequence ID" value="MST35237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST35237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="212" mass="22524" checksum="3E7079170BF352AB" modified="2021-04-07" version="1" fragment="single">MIRLAPSILAADFAALGAEIDRVAPEADWLHVDVMDGHFVPNLTIGPPVVKAIRRHTDLYLDCHLMMTDPGDYLEAFRGAGADSCTVHVEVGRTAELLGATRELGLGVGLALNPDTPFEAVEPWLDRIDLLLVMTVHPGFGGQSFMEGVVPKIESAGRAVRDRGLDVVIEVDGGVDARTAGRVAAAGARIRWSRSSCWRGPSSSCSTTPGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ90</accession>
    <name>A0A7K0JZ90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001276">
        <property type="protein sequence ID" value="MST34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9106" checksum="AC8798F0FADD915E" modified="2021-04-07" version="1">MTLRSITCQCGTSRPGSQSQCPNCGRSDGREVLERTLQPRRTVRPAGPPQTGDLIGCGLCGLARVRVDGSDLVVCPFCDTVRDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA0</accession>
    <name>A0A7K0JZA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripla_BP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001587">
        <property type="protein sequence ID" value="MST35290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="23127" checksum="C3F19C2FB4E79B02" modified="2021-04-07" version="1">ARNFPVVLLAGSGRSRTAVTVRADNQMGMRLLADHLVVEHGLRRLAFLAGSTGSPDSDARAESFRAEAERLGATLEPPEWWEGDFTSAGAAAIVRRRLAQGGPLPQAIACANDSSAVGAQHALAAAGVQVPTDVAVAGFDDIPLARHLTPALTTVHQPIQQLGMVAVEALIGKVEGAAGGARDIVLPTQLVVRASCGCPATVADALSDWGADPPPSPAGSTTALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB5</accession>
    <name>A0A7K0JZB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001614">
        <property type="protein sequence ID" value="MST35315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="16633" checksum="3A1E45857BD61C3E" modified="2021-04-07" version="1" fragment="single">ADALGVDGRTVRRDVERLRSLGYEVAATPGVAGGYRLQVVGGQVPLLLDDEEATAVAVVLGVMASVAVPGVEAGALKALTKLDRLLPPRLRGQLSSLRQSTVAVLPRMEVVPAEQLVAFARACDAGERVRFCYRSWGGEETERRAEPHHVPPAVGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC3</accession>
    <name>A0A7K0JZC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">holA</name>
        <name evidence="2" type="ORF">GHK86_21570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001604">
        <property type="protein sequence ID" value="MST35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="13"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="332" mass="34661" checksum="516F641FE7769B50" modified="2021-04-07" version="1">MNAPADRVAWLVDGDDPTLVSEAVRGLLDELVGDAERSLVVEEFSGDDVDLAAVADACQTAPFLADRRVVVVRDVGRFGTEELAPLLAYLESPVETTALVLGAGGGRLAPKLVAAVKAHGHVQSTAVGRDAKGWVHDRLTRSGLRLDPEAEARVTAHLGADLSRLPGLLEVLVSVHGQGARLGADDVAPYLGEAGSVAPWDLTDAIDAGATDRALEHLHRLLGAGERHPLVVLAVLHRHVGNLLRVDSPAITTEAAAAEALGIAKGRSTFPAKKALNARRRYGSGGVAQAVGLLADAELDLKGATELPGEAVLEILVARLCYLARAAGARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0J2</accession>
    <name>A0A7K0K0J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001587">
        <property type="protein sequence ID" value="MST35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="entry name" value="PTHR31451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="638" mass="69618" checksum="E1B5B95665610A1C" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMM2</accession>
    <name>A0A7K0JMM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplO</name>
        <name evidence="10" type="ORF">GHK86_00495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="17053" checksum="4754C3A197FA34D9" modified="2021-04-07" version="1">MKIHDLQPPAGSTKSRRRVGRGIAGKGGKTAGRGTKGQGARNNIKPGFEGGQLPLTQRIPKLKGFKNPFRVEYTVVNLDTLEEFGGNVVNPDTLRAAGLVHKHGLVKVLGRGQLTRALEVSAHALSASAAEAIRSAGGSVEVIPPPWGDRRPAAKGNALTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU0</accession>
    <name>A0A7K0JMU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplR</name>
        <name evidence="9" type="ORF">GHK86_00510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13057" checksum="1B8A22CC95070F1B" modified="2021-04-07" version="1">MSYSTKQKQQALARRHHRVRKRVSGTTERPRLAVHRSNKHIVAQVIDDRSGRTLAAASSVEADVRAAGPTGNKTAAATVGRLVAERARAAGVTAVVFDRGGFLYHGRIAAVADAAREAGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN00</accession>
    <name>A0A7K0JN00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000036">
        <property type="protein sequence ID" value="MST31318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029764892" evidence="1">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="32284" checksum="61E3FE274CDF552A" modified="2021-04-07" version="1">MTRLPRILAGLAAALSASLLASACSAQPGAASVNGTSINASSLNAELAQLSANRAYIKAVNRASAQAGQQVSGAARGTYNSLWTAHVLTGLITAEAVGQYLHERGRQPGAYQVEVARAVEAADYGPYWQGFSASYRETLTNRAAELAQLGAPALPAAELRSAYKQLGGYLFTRVCVRAPVFATRAAAEAYASTVPSGSAAPGHGSAAVCYTPAQLDVQPAAFTNAVRALPVNGAGRVVATSSGYEVVVVTSRRAIPLDLTLRRTLDAVVASGSGAAPQVEAVLSRSKVTVDPQYGSWKGSAAQGYQVVPPRAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNB3</accession>
    <name>A0A7K0JNB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000064">
        <property type="protein sequence ID" value="MST31418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="166" mass="18436" checksum="5AF87A738021EDB5" modified="2021-04-07" version="1">MVDFDDWYEREHPRVLAACRAVGGDVDAAAEATSEAFARAAQRWASVRTMAAPGGWVQVVALNQLRRSLRRRRVERRLLPRRGEGVEGPPPPDVDVWRAVAALPERQQRCVVLRYVHDLPEAEIAALLGIARGTVASTLSTAREGLRVRLGHEAHDDDRDGEHIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN2</accession>
    <name>A0A7K0JNN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">acnA</name>
        <name evidence="13" type="ORF">GHK86_02390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="WJHE01000100">
        <property type="protein sequence ID" value="MST31580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="11">
        <location>
            <begin position="74"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="12">
        <location>
            <begin position="699"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST31580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="895" mass="96085" checksum="FFF26E6B95BC78E5" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ8</accession>
    <name>A0A7K0JNQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="509" mass="57027" checksum="EDDB2C389A8DC027" modified="2021-04-07" version="1">MNPILIPELDETALIVALEAEAQYDRTWLPPEPWWDALLSSKSDLASAIHRRLTRGGKWDRSATVDVRKPGHGIRPVSVMSPEVRIVYRAIASALVQPENRPDRSAKKYADFVLEPVWGGNRNRTAPFLNLLDTRYSHVVITDIVAYYQYIDHALLRDELDLGGGHIGMIDALVELLADIEGRSFGLPQRSAPSDWLSDRYAARIDRWMTRDGFDVWRYNDDFRVGCTSYAEALRAIESLSRAARELGLVLNDQKTAAPTFATYLNHNVNVEIHDASAQIDPSDVEAAISTDYAPEDDEQALAEAVQTLEQLWDPETDGQPMPNARWDLRNLSADQHRAVRRALNTLTRQGHDHALPRLLSILAYQPAMTHRVVRYAEALARHRPEDIGRFIELAIGRLSLNEWQRAWLAFGARACSVELDEDRPLASWLQTQMGARPNSIVAAEAAVTLAESSRVTFEVLERHLRDVSPDFGPWYLHAVAVLNRNGAVNPQQLGALRHSSAVAAAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNX5</accession>
    <name>A0A7K0JNX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L,D-transpeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000112">
        <property type="protein sequence ID" value="MST31672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029762844" evidence="4">
        <location>
            <begin position="31"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="6">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="306"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="433" mass="44331" checksum="36206E564A780626" modified="2021-04-07" version="1">MVGGSAVVVAGLIVGVAACGAVPNAGSRSAAGSSSGGTGTATTAPSTTTTTVPLTVASVTPAPSSALPTDGAITIDFSAPLASPVQPTLTPPVAGHWSQSGRTLTFHPTGGYIPSTHEVVTVPQGIKAVEGGQSVALSSSYKLSYHVATGTYLRLQELLSELHYLPFTFQPSAQASTAAFVTETGSTPPSSSSTSTTPGTTAPSTTSTTAAPTTTTTAPALQREPTQADAISTSPVPGTLSWAYPNIPHDLAAAWSPGKANVLTKGAVMAFEADNGLAVDGIPGIQVWKTLLQAVATRKVDPHPYNFLMVNETGTEYLRIWSAGKFVYTTLANTGVPGAATAPGIYPVYLRYSHQIMRGTDVNGTKYAVPVSWISYFNGGDAVHGYPRASYGYPQSNGCVELPIPNADMMWNSAQGYDGYGVLVDVSSGPLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP38</accession>
    <name>A0A7K0JP38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GHK86_01075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="10029" checksum="F505B3CFADDA620F" modified="2021-04-07" version="1">MEWDVDDWREEASCRDTDPDLFFPVGTTGPAVEQIATAKAVCYECPAQSACLEFALETNQESGIWGGTSEEERRKLRKTWLASRRRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP57</accession>
    <name>A0A7K0JP57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000114">
        <property type="protein sequence ID" value="MST31677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="10047" checksum="6F7DAFB37A1B1676" modified="2021-04-07" version="1" fragment="single">MTLNGMAVRTTWKAHHACGRRARKPAASHDLSATRPSERPGNTRWPAKAVEGGRRVRCQLLAAANDPLGVSDGDFAFRVENPARGIDIASWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP79</accession>
    <name>A0A7K0JP79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000045">
        <property type="protein sequence ID" value="MST31359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="10771" checksum="CDECF8C4CE6F6904" modified="2021-04-07" version="1">MSQQQTDEQAPPRGHVRVVYLGPVAPHWRVDSDFGDRTVIEEFRQRAMARLLLLPPHDPQFRRNRERVVRDAERENLLLDWDLGLPEDDGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA0</accession>
    <name>A0A7K0JPA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B12-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000050">
        <property type="protein sequence ID" value="MST31374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="69"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="18082" checksum="2BBB42EAFF44E192" modified="2021-04-07" version="1">MVDHRRHPGRADGGVTLAEVCDHVLVPALTGIGEGWARGELSVAEEHRASAICGRALARWSPAPPGRHRGVAVVCSPTAEGHELPGLMATVVLREQHWRVHHLGVGVPVDAVERLVEVERPDLVVVSVTWSEAVDDGRLLGKLLEAPRRRVLVGRPGQSLGSLSAELAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA6</accession>
    <name>A0A7K0JPA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaB</name>
        <name evidence="14" type="ORF">GHK86_03470</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="WJHE01000136">
        <property type="protein sequence ID" value="MST31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="188"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="453" mass="49265" checksum="FB61774560F85392" modified="2021-04-07" version="1">MVQSLDDARRRNQAANRVPPHNLQAEQSLLGAMLLSRDAIAAAVEACGAEDFYKPAHGHIFEAITTLYSQGEPADPLTVSDVLKRAGLLDAVGGLPALTALQTDTPATANAGRYARIVEEHALLRRLIGVAGEIAELGYSVPDDVTATVDRAESLVFDIAERRVTDTMKPLRELLEESLDRLSALYSRQEPITGVPTGFRDLDEQLSGLQPSALLIVGARPAMGKTAFALGIAAHSAMVAQVPTLIFSLEMSHAEITQRLLVSEARVPGSRIRNGQLHESDWPKISNAIGRLGEAPLFIDDNPNVTVMEVRAKARRMKAKEGGLGLIIVDYLQLMTGRSSAENRQVEVSEISRGLKILARELQVPVLALSQLSRTLEARADKRPVLADLRESGSLEQDADVVMFLYRDEMYNPDSADRGSAEVIVAKHRSGPTGKVNLAFLDHYTRFADMARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB4</accession>
    <name>A0A7K0JPB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">GHK86_03455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000134">
        <property type="protein sequence ID" value="MST31785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="16"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="240"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="509"/>
            <end position="512"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="601" mass="66078" checksum="D3A363DC4012FAA9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE7</accession>
    <name>A0A7K0JPE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="9706" checksum="CCC8BCB9FBE1EEE1" modified="2021-04-07" version="1">MAGRLGLVRAVEDTPVGPLAVYRHGGGVVAVCDVCPHARARLSEGSLEGGVITCPAHGSRFEVATGVRVRGPADAGLATYTVVVEGGRVWLVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI2</accession>
    <name>A0A7K0JPI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000164">
        <property type="protein sequence ID" value="MST31882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6537" checksum="8B79535D831A446B" modified="2021-04-07" version="1">MWQPGSPTRRLAGAAVATLAVAVGLAFGGDLWGRLLASGAFGGLVTVLPRVWRSFRHPDPPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK2</accession>
    <name>A0A7K0JPK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000166">
        <property type="protein sequence ID" value="MST31890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="22779" checksum="6822369E856DF27B" modified="2021-04-07" version="1">MSPLQHTGNVSACRVWHHGTVGSDATANRPMRADARRNYDRIVEAARAELAERGTDASIDDIAKRAGVGSGTLYRHFPRRIDLVEAVYSSDVAILERAAEQAAAEPDAFEGLALWLRAFVRYAETKRVLLNELHEAFERNPDLRVQLRERMRAAAERALAPARTAGAVRADLSAEDLLQLVGGLCLSALGTPTSNERLLDVVLAGLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK9</accession>
    <name>A0A7K0JPK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/arginine repetitive matrix protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000165">
        <property type="protein sequence ID" value="MST31888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="302" mass="32383" checksum="D368AAFEC1EC2176" modified="2021-04-07" version="1" fragment="single">MRPSLTEQRHAHAAAKIAEAQRTLATEVAKLVTGEDWRRFLDFQAKLHAYSPNNVMLAVAQHAQAFADGLVGSEHPTHLAGFHTWRALGRTVDRGQHGYAILAPCRYDRRVALDPNGQARPLAKDEAPGADEQVEKRRVLAGFRVEYVFDVSQTSGVPLPEPPRPTLLAGEAPAGLGAAVLEMIEELGFRVDTVPDASALQGANGQTNWGSRTVLIRADMDDAAMVKTLIHEAAHCVLHEGPPGQCLPRPVKEVEAESVAYVVASVHGMPTDGYSFPYVAGWFPLPAMSPSTTCTAEGGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR1</accession>
    <name>A0A7K0JPR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000183">
        <property type="protein sequence ID" value="MST31946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="221" mass="24854" checksum="62C7D10C87FF307E" modified="2021-04-07" version="1" fragment="single">MSAEHVLSATESYTVQRRGERRRYLPLYSLMVATEPLPDAVWTQLGWRDGLLVRDRRHLFFYAQRTADGRIAIGGRGAPYHLTRPIDERCERNDEVRARLEATIRREFPAAAGAAVTHHWGGPLAVPRDWSMGVCYDRVTGLGWAGGYSGHGVVAAHLAGRTLADLVLVRDSELVTLPWVGHRARDWEPEPLRFLASTAIVRTLGAADRHEDRTDREARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT2</accession>
    <name>A0A7K0JPT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="720" mass="76133" checksum="751E37A2DED98990" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ12</accession>
    <name>A0A7K0JQ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000110">
        <property type="protein sequence ID" value="MST31659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045361">
        <property type="entry name" value="CIS_tube_prot_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19266">
        <property type="entry name" value="CIS_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="181"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="25361" checksum="677E4D263DEB96DD" modified="2021-04-07" version="1">MGVAGSGRSTSQTSQKDLAKKAYLLTEKKAKIPCLFNPENFSLSMQNSWNSEARPGQDVQVAQFTGASAGTLSLTLFFDTTDTGSDVTSYTNQLQQLMAIDPSLQGTKSASNNQRPPWVKFCWGNFQSWPAVITSLSLTFEYFSSSGTPLRARASLSLQQYTDPNRLPRQNPTSGTPRPHRVHRVQRGETLDRIAAQHLGKATAWRAIADANGLDDPLALAPGRYLAIPENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ29</accession>
    <name>A0A7K0JQ29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000198">
        <property type="protein sequence ID" value="MST32023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029903925" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="61" mass="6137" checksum="CC22E5682890164B" modified="2021-04-07" version="1" fragment="single">MPCNLLHPLGCAASIAKAAAGDAFASIAHDFASTAASAVDWLWSQLGQATAVQLSGPGFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ36</accession>
    <name>A0A7K0JQ36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000204">
        <property type="protein sequence ID" value="MST32068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="115" mass="12180" checksum="B5EBF13AB624F473" modified="2021-04-07" version="1" fragment="single">MRPPALLVLADGTEFEGEAVGAWGDRPATGEVVFNTALTGYQEILTDPSYAGQVVCFTYPHIGNYGVTDDDLESRRPAAAGLIVREMTDRPSNWRAGGSLPAFLAERGIPGIAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ58</accession>
    <name>A0A7K0JQ58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000119">
        <property type="protein sequence ID" value="MST31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KdpD" evidence="5">
        <location>
            <begin position="152"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="4">
        <location>
            <begin position="382"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="534" mass="58021" checksum="77D8306D1B2EB81D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQF5</accession>
    <name>A0A7K0JQF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1206 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000231">
        <property type="protein sequence ID" value="MST32172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="197"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="28198" checksum="A05B88EE32D62296" modified="2021-04-07" version="1">MVQAPGREDDDEATRSLSVLGRLGLAGQTAFFAALTGLTVRIAALGGGSGHQADPHGALALVSRPVIGKVAIGIVALGFLLFGVTRVLGAVRDRDAPTGRRVATGLQGVFFALAVWVPASYLGGDGRAGSQQQQQRTTAELLHLPGGRGVVVALGLVVLVVCILQIRVALQRDFRDGLELAAAPRVVRRVVDVAGVVGIIARSVVFLPVGAFLIVSAVRADPGQSYGTDAEMLQLSGHPWGVAVLALVAAGLATFVVYSALETRYRQVLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH5</accession>
    <name>A0A7K0JQH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000237">
        <property type="protein sequence ID" value="MST32192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="70"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="25834" checksum="B5F9E574CC7AA64D" modified="2021-04-07" version="1" fragment="single">MATAGGGWEEWCPACGRTYPVAAPVWRCDCGGLLDLRGPVVPEPVVAGGPWSLWRYAPVLPPLPAAAAVSLGEGMTPLVPAADGCWWKLDFLQPTLSFKDRGAAVLLAAAAGAGVERVVADSSGNAGTAVAAYAARAGIAAEVWVPGGTSRGKLAAMEAHGATVRVADGDREAAAAAARARAGDPGVFYASHVYQPLFVAGVKTVAYEIWEQRGGVAPDVVVVPAGNGTLVLGADAGFGELLAAGLIDRLPRIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI3</accession>
    <name>A0A7K0JQI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000150">
        <property type="protein sequence ID" value="MST31829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8400" checksum="E368DBEE52EBEDF7" modified="2021-04-07" version="1">MAESPSGADRSEGPRTSRSRRDAAISFAAHQHSALGELVEFLTGNTWPFHAEASLDHAAAHLEEADGFEVELVARPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ1</accession>
    <name>A0A7K0JQJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000234">
        <property type="protein sequence ID" value="MST32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="407" mass="44430" checksum="BB93964A50DFBA45" modified="2021-04-07" version="1">MPALQRAIGNRAVVDLLGGGANRGERLHSVDATRIQRFSFQDRPVPDFSGATITRSAAGKRGVFFAAAGGSTVVIKLDDEAAAPTETANILIKKLGGIETPDARAITDKKSPEWRSVKTAIQQKVGDDSEGLEQGRESTPRMLGNAKAIWLMPELKALSFAQLVSDRRYHTTLMSALRNEETMRQIGRLAVIDGFLGNWDRFLVPGKIANIGNIMLSEDGKNLVAIDSTVSRLKAIAFTEIDAQQQPDEEKRRRGNQAREKNAVKDKITFLQSVIDDQDAWIRGFFRTLIGISEQNAGAPLPPLLKEGGALAGFWKKAEQNIKAGLIEQQAVLAKAVKKNGKVKGVLEEKNVGDYETAKVSGKYAALRARGLSHEEAEEELRSYRGYRAKRGALPTGLKWTAKSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQT7</accession>
    <name>A0A7K0JQT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000263">
        <property type="protein sequence ID" value="MST32283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029662997" evidence="1">
        <location>
            <begin position="33"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="430" mass="45168" checksum="AA6AACF794AC2038" modified="2021-04-07" version="1">MTGKRIRRLGSVVAVLAMAGAGAAVPAMTAGATTTGAPTPISDAQMHPSYTTIGGGATVLPTTRTVAHWWGSTTNPTNGVTYGYNMVGANPNTCSGAACDVTVRADITPINVVVDGQTFSGSDVVAPTLASPVFALNNYGSTAHATDSTGGKGPGGTLSQGDQGVPLQLEDATMRAQFNKTGAASPYHLRLQPTVLPAITIDVPPNQGTLLASPRGIVFADVNITWWSSQIQNLEQSANPTHLPIYLTNGVMNYEGHNPLNCCVIGFHGTRATGNGGGSTNANGNAKVQTFAWASWVQPGTFNPGSTWALQDIQALSHEISEWADDPFVNNAVQPWLTPTAPQYGCSGYLETGDPVVGIGFTMGTNTYDQNQYADGSYHPEDEVFLPWYMRQNPNTTSEPTQSVSSYGGRYTLMGDLNPFQGFRQPATGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQV4</accession>
    <name>A0A7K0JQV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000264">
        <property type="protein sequence ID" value="MST32287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="21440" checksum="3E3BB6E9B3028F79" modified="2021-04-07" version="1">MTVEVRDYQPGDEEAWVRCRVLAFLHTAYFDDVQPARPVCPSPGFGLVAVDGNELVGVIDVSVSPSEQLATIDTVAVHPDSQHRGVGTALLSEARSRGLRAGATTIDAWTRDDEATLRWYRSRGFAESEHYLHVYANYYTDSTEPGRAVESTRPELKPIIVFSHANLEAEQELRRQFARVHVCRRFSQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR47</accession>
    <name>A0A7K0JR47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000286">
        <property type="protein sequence ID" value="MST32401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="26486" checksum="8B47C575143E78F2" modified="2021-04-07" version="1">MQLGLTGRRALVTGGSKGIGYAICEELLAEGAAVVFCARNPGEVAAAAASLAERGPATGVVCDVTDAAAVTAMVAAATETLGGLDILVNNAGGAHPGGFEDLSDEDWQGDLDVKLFSQIRCCRAALPHLRVSPAPRVVNINAVYGRYPDPAFFATSVNRAACQNLTKVLAAQYGPDGILVNSVNIGFVDTPQWDNIRAKRAPGSSKDEFFARLSAAEVPLGRFGTTDEVSGVVAFLASDRASYVTGAVIDVAGGMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR81</accession>
    <name>A0A7K0JR81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000292">
        <property type="protein sequence ID" value="MST32440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="24261" checksum="B66AEBE24591A916" modified="2021-04-07" version="1">MVSPSRQGWCAVAEHPNAALIRRLSDALASGDLQGIEEVLAEDAFVHDPGRGVVAGDYLGREQAADFFAELLEQTAGTYKAEVIDVLANDQRAVLIQRSTARRQHRSLDTRDVLVAEIHDGRIRSIQIYSADEDAENAFWAKVGSPPTRHSELSDVQLDQLGEVLRELGKAKPFSGSEALVAALDAGVVNGAADIGSAIDDLEDAGVLREVTRNPPRWRAADAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT4</accession>
    <name>A0A7K0JRT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000346">
        <property type="protein sequence ID" value="MST32627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="8125" checksum="301AB0B990B19E7A" modified="2021-04-07" version="1" fragment="single">MLVIGLGNPGAEYAGTRHNVGADTVERLASRHGQRLRGGRYQSLVAEAVVGGRRLALAVPITYMNDSGLAAAPLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRW4</accession>
    <name>A0A7K0JRW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tatC</name>
        <name evidence="7" type="ORF">GHK86_06175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000267">
        <property type="protein sequence ID" value="MST32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="29542" checksum="0950B97E2FAB8925" modified="2021-04-07" version="1">MAVTEQQEPFTNGSAAAEEAPEPGSMTLFEHLAELRNRIIICAVAVVATTILAWFFYGPAIQFMRHPYCQFVHLHPNKALTKNDCQLFITGPIEGFTTRLKVSLYGGLVLAAPVWILQLWRFITPGLKKSEKRYILPFAAAATCLFALGVAVAIFVFPKALRWLILVSGPGIVPIFRPSQYFTLYVLMCLVFGLIFIYPLILVALELTGVVPSARWRKWRRPAIVVLAAVAAVATPSNDPISFMALAIPMYVFYELAIVVGRVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS03</accession>
    <name>A0A7K0JS03_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuc_Holl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_08325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000370">
        <property type="protein sequence ID" value="MST32726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019287">
        <property type="entry name" value="Hday_junct_resolvase-rel_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10107">
        <property type="entry name" value="Endonuc_Holl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuc_Holl" evidence="3">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="174" mass="18645" checksum="252F86432527570A" modified="2021-04-07" version="1">MSTTDVLLLVVAGLAVLGAWLVAVRARLDLRAHRRQYRHTAEDLAAARRDSVARSHAVVSGKVREHLAPLLPDFVEQFDGRDARFLGSPVDFVVFDGLDAGSVERVVFVEVKTGSAGLSARERLVRDAVEAGRVEWQVLRLPAAVDDGAAGGPVPALPAPGAPARRGGRRLFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS27</accession>
    <name>A0A7K0JS27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmI</name>
        <name evidence="6" type="ORF">GHK86_08310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000369">
        <property type="protein sequence ID" value="MST32723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="7307" checksum="09FBDEA849C0C482" modified="2021-04-07" version="1">MPKMKTDRGAAKRFKVTGSGKLRRRRAFKNHLLEKKSSTRTRRLSQETDVAPGDVRAVKRLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS31</accession>
    <name>A0A7K0JS31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000279">
        <property type="protein sequence ID" value="MST32369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="34"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="449" mass="47179" checksum="51F1896CA068D983" modified="2021-04-07" version="1">MTRLADRATLPLPLVGDDTPVPCADGVERPYLSLDAAASTGALPAVARRVEEFLPRYSSIHRGAGYKSRQATDAYEAARAAALDFATGHGPARDRVAIFGRNTTDAINHLAYRLRLRADDVVVTTAAEHHANLLPWARACRRRHVETGTDGTFGVQDVEAALDAGGGPPPKLLAVTAASNVTGWMPPVEQLVAAAHARGVPVLVDGAQLAAHRPLPAEADFLAWSGHKMYAPFGVGVLVGPREAFTDGDPFLAGGGAVEYVGLDEVVWAAPPEREEAGSPNVVGAVALHAAIDELRRVGWPAITAHDVELAHRLRSGLAAIDGVTLLGPAADAVRLPLATFTVDTVPHALVAARLSAEHAIAVRHGCFCAHPYLTRLLGLTPAEVDAFQRAMRAGDRRLVPGAVRASAGINTRPEDIDRLLAAVADIAAGRPAPVEYVQDPSTGDFEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS34</accession>
    <name>A0A7K0JS34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000379">
        <property type="protein sequence ID" value="MST32751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="253" mass="25523" checksum="B3C81F4103C33E53" modified="2021-04-07" version="1">MLTVTAPRPGVRVLRLERPDRLNALTAGLVAALHAALDDAHADRACRAVVLTGAGRGFCAGVDLDGYGVPPGAEGLAGAAATRAEQEQISSLVPHLRAIRPPVIAAVNGPAAGAGLALVLGADLRLAAESARFTTAFLRAGYSAADAGTSWLLPRLVGVARAHELMLTSRRVDAAEALRIGLVTSVVPDAELLDAALATAGTIGEFDPWAVGITKQTMWAALDVPGLGAAIALEDAAQVMCVAGTTPPAAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS53</accession>
    <name>A0A7K0JS53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1049 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_08560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000384">
        <property type="protein sequence ID" value="MST32771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="7">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="13635" checksum="7727700885DA6580" modified="2021-04-07" version="1">MSAAVQRPGPEDSLPSAVTPTAGPGAQGAPTPVPDASLEPRRTRTGTAYVASIVGIVVAALVIVFIVQNLHDATVHFLPWTFRLPEGVTILASAVAGALVVLLVSLARILQLRLTARRHRRRHAAQTLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS84</accession>
    <name>A0A7K0JS84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-galactose-lipid carrier transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000394">
        <property type="protein sequence ID" value="MST32802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="70"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="286" mass="32467" checksum="EDBA8E3E947570E5" modified="2021-04-07" version="1">MGDGPRQPTGTPIASTPHHPDVLGSPAVGILDTVDLSLRLGRKEEATRLAAAQRRLQHLRLATAGLLGDEQPGPPICVVMEGWDASGKGGAIRRLVANLDIRHYRIAFFAKPTATEKAHQYLWRFWPALPGWGEMTIFDRSWYGRVLVERVEGFASAEEWGRAYGEIVDFERQLAADGMIIVKFWLEISHEEQLARFESRRADPLRAWKLGEEDWRNREKRPQYEAALRDMFSRTDHELGPWDIVPAEDKRYARVMVLETTIARIEAGLRRQGFEPPAPLEPDEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST0</accession>
    <name>A0A7K0JST0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000333">
        <property type="protein sequence ID" value="MST32569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10524" checksum="F677262CDEB9A397" modified="2021-04-07" version="1" fragment="single">MPPSFADYRIATQGDGAAPGRGQVWLARPPARLGLDGDVALVGLGPVDDADWAVVTGRLAELASVRSPHLPALLEAGRERQDGRGPGWVTRDHPQARPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT21</accession>
    <name>A0A7K0JT21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000478">
        <property type="protein sequence ID" value="MST33088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="25733" checksum="A37B80E81A3E6740" modified="2021-04-07" version="1">METESVGPVGVEERYAVFPFYLCLDASASMAGAPVESVNRQLPLLRAAVGEDPAVAEVIRFGIVTFNDRAETTLPLSDLSMIESMPPVVAQGRTSYAAAFDHLRAVIEDDYHASRARGDRWYRPAVIFVSDGRPTDDRERWLAAHSRLTDPGWKRRPNILAFGFGDADSAVLAQVSERKPNRAFIAAEGAEPAAVVPELLAGLIQSIVSSSASVYTGEAQLVPPEVPSMVPIPVDQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT26</accession>
    <name>A0A7K0JT26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ORF">GHK86_10270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="WJHE01000485">
        <property type="protein sequence ID" value="MST33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="56"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="394" mass="41481" checksum="D8F95EA0F44C3714" modified="2021-04-07" version="1">MGLGEPSESGRFGDFGGRFVPEALVPACAEVEEAFRSAWADPAFVGRYRDLLRDYAGRPTPVTECHRLSEELGVRVLLKREDLTHTGSHKINNVIGQGLLTVAMGKRKLIAETGAGQHGVATATAAALLGLDCVVYMGEVDTERQELNVFRMRLLGAEVVPVRSGSRTLKDAVNEAMRAWVAEVDDTHYCLGSVMGPHPFPWMVREFQRVVGDEAREQCRALLGGADPDLVVACVGGGSNAAGTFAGFVGTTARLVGVEAAGGSAVGRGVPGVLHGMHSLLLQDEFGQILEAESISAGLDYPGIGPEHAHLASTGRAEYTAAGDDEVLAALQLLARTEGIIPALEPSHALAWLVRAARDGSVPAGSTVLLTLSGRGDKDAEQVMRILGDSVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT39</accession>
    <name>A0A7K0JT39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_08135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000362">
        <property type="protein sequence ID" value="MST32689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="494" mass="51638" checksum="872242BB84405D81" modified="2021-04-07" version="1">MGTAESTLASRAARAPILPLALAQFVCSFAGTSTNVAITPIAKDLGTTVSGVQTAITVFTLTMAALMIPGSKLTDILGRKRCFVLGLFIYGAGALLTSLAQGLPAMITGYSLLEGVGSALLIPPVYILVTVSHRDVRSRAKFFGIVSGAGGLGAAAGPLVGGLITSSISWRATFGLQLVLVLLIVWLARSITDTPVARPRPTFDVEGAVLSAAGLVLVVIGLLETRTYGWFVSRADFSIGGVVILPKGSMSPVWLYFAAGAAFLVWFLGHLRRRERRGRAVLVSLRMFSRRAANLGMATQFAQWMSMQGCFFVVSVYLQQVRHFDAITTGLILTPATAGILASSAAAQRLASRRTQRTLIIAGFVLASSGMLLLLVLVRPHNDILLTVPGTLAFGLGVGVMLTASVNLVQSAFPARDQGEISGLSRSVSNLGSTFGTAMAGSVLVAAGIHLKDGRDFGAALLVLLVFTLLGLAAAVFIPRERAATGATALTHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT42</accession>
    <name>A0A7K0JT42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000489">
        <property type="protein sequence ID" value="MST33115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="80" mass="9277" checksum="100DFB972BE20121" modified="2021-04-07" version="1">MKPLRFTRRSRRHRIGRTSARHVIATVAAVEYKDDQTGAALLTWIGDDERGRELEIVALDRPDCLLVIHVMPTHYRRNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTD3</accession>
    <name>A0A7K0JTD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mechanosensitive ion channel protein MscL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000506">
        <property type="protein sequence ID" value="MST33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15282" checksum="6E82081525129B87" modified="2021-04-07" version="1">MLKGFKSFLLRGDIIVVSVGLIVALAFSTLISAFTTNVIDPLVNRAEGGGHTIGLGVQLGQAGQKATFINFGALIGAIIYFVIFMAVLYFAIVLPYKAVSARRGVVVFGPPDPVKACPACLSDDLPLGATKCRYCGTELVVQSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ1</accession>
    <name>A0A7K0JTJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000535">
        <property type="protein sequence ID" value="MST33250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="364" mass="38725" checksum="99A60126879846C4" modified="2021-04-07" version="1">MSPRRIAVVTGASAGVGRATVRAFARAGFDVGLIARGEAGLAGAAADVEAAGGRALQLPTDVADFAAVDEAARRVEEELGPIDVWVNDAMTTVFAPAWEVEPADFQRAVEVTFLGQVWGTKAALARMRPRDRGSIVNVGSALAFIGIPLQSAYCSAKFACRGFFESTRAELLHEGSHVRMSMVHLPAVNTPQFNWCQTTLRHHPQPVPPIYEPEVCARFILEAALDGRRDKVIGSWNKLLVMAGQLFPGLGNHYAALAAWEAQLTGQTVAPDRPDNLRHPADARHDAGAHGIFGDKAGGFLDKSFLESLPNTAKNFAVAVGKVTREKQATYARVVAHRREQHPAEAAGAGTGPTGALQTAGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL3</accession>
    <name>A0A7K0JTL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemerythrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000545">
        <property type="protein sequence ID" value="MST33282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20363" checksum="89867665A45394F7" modified="2021-04-07" version="1">MTDAFTVLKADHTEVETLLTRLLGGPGPVSGASRDPAGDAEQLVVAESGHEAAEELYFWPAVRQRVAGGADLADEALRQEREGKRVLDRLRRSRPGDADFDRLVTAFAAAGRAHIAYEEDQVWPKLRAVLGDGEAEEMGERLASARAAGPTRPHPAAPDGPAGLKTAGTAAAVLDRLRDAVIGRPRSRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR0</accession>
    <name>A0A7K0JTR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ORF">GHK86_11400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="WJHE01000558">
        <property type="protein sequence ID" value="MST33320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="9"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST33320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="412" mass="42733" checksum="A49EA22BCF570405" modified="2021-04-07" version="1">MHNATGRRVVVTGIGAISPLGHTADSTWDGLVSGRSGVAGVEGFDSADLPVRIAAQVRGFDPVAVFGKRQARHLDRVVQLALVATREAVESAKLDVAADPHRVGVVYGTGIGGLHSLEEGHRTLLDRGPDWINPYLLPMMIPNMAAGQIAMEWGIRGPSSCTITACSASAQAIGEASDLIRLGRADAVVCGGAEASITRLGLSGFAAMKALSTRNDEPERASRPFDLRRDGFVMGEAAATLVLEERDYALRRGAPILAELAGYGATSDAHHVTSPLPDGDGAMRAMLVACADAGIAPDEVGYINAHGTATPPNDRTEALAVRRIWGDRTPAISSTKSMTGHTLGAAGALESVACIKALTAGVLPPTVNLDEPDPDCAADHVALTARVADVSVAMSNSFGFGGHNASLVFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR4</accession>
    <name>A0A7K0JTR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000560">
        <property type="protein sequence ID" value="MST33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="22282" checksum="CA0FF90D9DDC17DF" modified="2021-04-07" version="1">MSTSFAITWDYRCPFARNVHDHLVTALEAGGPWDVQFLAFSLDQPHVEEGEPSVFDQPDRYPGLLANEVGIVVRDRLADRFLAVHKALFDARHRDGADLRRRDVLAPLLEAAGVPAADVFAEIDAGWPLETFRKEHLGAVERHDVFGVPTFIVGEHATFVRLMDRADGGADKAVATITRIVDLLTGWPELNEFKQTRVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV3</accession>
    <name>A0A7K0JTV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046038">
        <property type="entry name" value="DUF5996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19459">
        <property type="entry name" value="DUF5996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="33074" checksum="87A0FCF93B9318E1" modified="2021-04-07" version="1">MTAPGGWPAIPYEAWNATCDTLHAHTQVLGKLAAGLAPPEPQLQHAALRLTARGWETLPLPAPDRSGAVVVTLDLHAHQAVVEHSDGRRRSVALAPDQPVGQVTRDVLGALTEMVGPVAFDPRPQETPWSVPLDEDDEHATYDPAQVGGYFAAATWAAAVLAALRAPYRGRATPVNAWWGSFDLAVSLFSGRPADPGASDFIRRNAMDTQEVAVGWWPGDPRYPKAAFYAYAHPAPPGYDSATLEPSGARWEPALGEYVLDWDDVIATDDPHGTALAFARAAVRHACGACDWDPALSASVEGHPPPVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU06</accession>
    <name>A0A7K0JU06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000587">
        <property type="protein sequence ID" value="MST33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="6462" checksum="D7E5E2CB9E11DCC0" modified="2021-04-07" version="1" fragment="single">MRVGLVCPYSLTLPGGVQAQVLGLGRVLRRRGIDARILAPCDGPPPEPAVTALGNSVPAVGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU15</accession>
    <name>A0A7K0JU15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/arginine repetitive matrix protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000475">
        <property type="protein sequence ID" value="MST33084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="16445" checksum="CEF616B70776C64B" modified="2021-04-07" version="1" fragment="single">MAGFGVAHVFSEFQTAGVPLPAGPRPVLLEGAAPAGLAEATTGLIEASGLSVELAASAADLGGANGVTDWSVGLVRVRADMDEAARCKTLLHEAGHVLLHGDATGRRLPREVKEVEAESVAFVVAAAHGMDTGSYSFPYVAGWFPLPAMSPSTTCTAEGGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU19</accession>
    <name>A0A7K0JU19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000592">
        <property type="protein sequence ID" value="MST33430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="286" mass="31974" checksum="F1F87110ECD5D399" modified="2021-04-07" version="1" fragment="single">MSPETARNIHLARRSFEVIDVVEILQHWHAGRPKSVVASSLGVDPKTVRKYVAPAEAAGMAPGGEPLGRAEWAERVRGWFPELVDARARSLTFSVIDVHRESIGEMLKTNTVATVHQRLRDEAGLAVSATSFRRYVWSEFPAAADPSKVTVMRPEVPAGEEAQIDYGFLGSWADPVTGRVRRVWAFVLVLACSRHMFVRPVVRMDQAAWVAAHLEAFDFFGGVPRRLVSDNLKTGVIKADLYDPRLNRAYAEMAEHYGVLIDPARASKPTDKPRVERQMPYVRDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU37</accession>
    <name>A0A7K0JU37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000602">
        <property type="protein sequence ID" value="MST33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="6232" checksum="326BF1E78107FDAB" modified="2021-04-07" version="1" fragment="single">MSADASRADRLDRASPLPLWAQLLAELRARLGAGEFDERFPAELELAADYGVSRNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU65</accession>
    <name>A0A7K0JU65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_12270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000613">
        <property type="protein sequence ID" value="MST33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="7">
        <location>
            <begin position="280"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="403" mass="41921" checksum="F77B224CE13869EE" modified="2021-04-07" version="1">MPEAVIVATARSPIGRAFKGSLVDVRPDEMAAQMVRAALAKVPQLPGETVEDLLLGCGQPAGEAGYNLARVVALLADLPGCPGVTVNRYCSSSLQTIRMAAHAIKAGEGDVFVAGGVEAVSRFGRGMADGLPETENARFREATERSAARAGGGMKPWEPSAGLPDVYIAMGQTAENVRELEGVSRREMDEFAALSQQRAVASQENGFFEREISPLERPDGSTVSRDDGPRPGTTVEKLATLQPAFRPDGEVTAGNSCPLNDGAAAVVVMSDTRAAQLGITPLARIVSSGVSALDPEIMGLGPVEASRQALARAGLSIDDVDLVEINEAFAAQVVPSARHLGIDWGKLNVHGGAIALGHPFGMTGARIMATLLNGLQAEDKTIGLETMCVGGGQGMAMVVERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU97</accession>
    <name>A0A7K0JU97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucyl aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000618">
        <property type="protein sequence ID" value="MST33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="33694" checksum="612E19F07737FCE1" modified="2021-04-07" version="1">VRLGEIRARAAARARDWVNEPARSMTPTRLAGVAGELARAHGLSLEVWDEHRIEAERLGGLAGVAAGATEPPRLIRLAYEPDGATATLAFVGKGITFDSGGLSLKPPTGMMTMKDDMGGAAAVLAAVAAAAELGLAVRVVGWVAATENMPGGSATHPGDVLVARNGTSIEVLNTDAEGRLVLADALSLAAEESPDAIVDVATLTGAQVVALGKGVAAVMGTDAGLVAAVVAAGARAGEPTWELPLVDSYRKQLDSEVADVKNIGKAGEAGSIIAGLFLREFVPADRRWAHLDIAGPAWSDEDRDWYAKGGTGWAARTLLELARGWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUA6</accession>
    <name>A0A7K0JUA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000633">
        <property type="protein sequence ID" value="MST33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="18409" checksum="6F5BE3E41E4A077B" modified="2021-04-07" version="1">TGFTGWNLEELRAGRSDVVFVRPPVDADPGVALIDLGEEELVVALPADHPLAARRRLRPADLRGEAVVSWPRRNAPGMHDRIEAQVWAGRRPNVVREEPDDEQVLRAVAAGVGLAVMIGTRLASLRVPGVAVRRFGVPVPTVGLALAWRPAVAPPAAARFVGLTQFSDVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY0</accession>
    <name>A0A7K0JUY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate dehydrogenase</fullName>
            <ecNumber evidence="6">1.17.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GHK86_11625</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000574">
        <property type="protein sequence ID" value="MST33364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009326">
        <property type="term" value="C:formate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="15">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="18">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="17">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MST33364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="943" mass="101748" checksum="516EA3C4E0598201" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV88</accession>
    <name>A0A7K0JV88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twin-arginine translocation signal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000750">
        <property type="protein sequence ID" value="MST33858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029791675" evidence="1">
        <location>
            <begin position="39"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="459" mass="49012" checksum="8CF7D40A4BC16A45" modified="2021-04-07" version="1" fragment="single">MPDAVTRRGFLKGALGAGVGAAALTVARSIGPAGEALAAPPPGGLSRAPGAPVAYQRFVTRPDLRPPGVWVDTTAAAVAPGQPAYIFATVNADLGPYPAGAQTGLMIFDRHGFLVFFRPLSGANTAFNFRVQPHPYKGQPVLGWFQGTLGAGYSTAGSYQLADASYTTIATVGEGNTGVPCDLHEFLLTDQGTALRTGYKASGNLLAGHAFDVDIPTGEPVFHWWSTMPRYGVPPADSYVPGADYFHINSIDLWPEPARNLLVSARNTSCVYLIERATGRIAWRAGGKASWAVMGPGCRYEYQHDARALPDGSGFSVFDDASQPGPEKQAWAKTIHLDLAAHPRPVATLVQQLDHYTDPVDVPFTGNNQLLASGDRFVGWGAQPFFSQYTAGGEMILDGRFPAGVGSYRTFTADWTARPRQDELAFVVRRGSRPGTFTGYASWNGATDVAYWRVWGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVD5</accession>
    <name>A0A7K0JVD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3054 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000766">
        <property type="protein sequence ID" value="MST33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021414">
        <property type="entry name" value="DUF3054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11255">
        <property type="entry name" value="DUF3054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="83" mass="8428" checksum="1D7173237786206C" modified="2021-04-07" version="1" fragment="single">MARPGASPRWAAAVIDVVVVVAFVAIGRASHHHAESVGGFLGTFWPFAAGLVAGWLVLGWLTGGRLAAGRLAGGRLAVGRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG4</accession>
    <name>A0A7K0JVG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000788">
        <property type="protein sequence ID" value="MST33957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="15358" checksum="3C9CA17F73F93686" modified="2021-04-07" version="1" fragment="single">MDLSGRVVRELAATTRFGDLRPMGETDSTNRVVADLARAGAPEGVVVVADHQTAGRGRLGRRWESPPGSGLLVSVLLRPAGLAPQRRHLVTSAVGLAAADACRAVAGFTPALKWPNDLLVGDRKLAGILAEGVGDAVVVGLGLNVSAAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI5</accession>
    <name>A0A7K0JVI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000794">
        <property type="protein sequence ID" value="MST33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="16593" checksum="A2BEAE8FF50D0D8D" modified="2021-04-07" version="1">MSNYESGTTRTIGIDAERLAGKTFDYQHDLSLVEDVDLLAATPGEDINWLEDVALLVEDGVPAVFDRYSNSFIKIYFPIPEGREDEIARKVLVKHLQSGNSYGIRLKEQHAKFPQPELGPWVERSRTVGEHWTPPEMPEGWERSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ3</accession>
    <name>A0A7K0JVJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000633">
        <property type="protein sequence ID" value="MST33539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="129"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="464" mass="52225" checksum="9603665F89C7C67C" modified="2021-04-07" version="1">MSDLEEFLAQEGRDDAIREVSRRIEAEGITYIYYQFVSVTGRIMGKGVPAPHWEKVARSGFQLVYGSTANLFIDRNGDYIGYGAEAGELVGLPDVDTFCPLPWDPKVARVFCTLFRGREERENGGGFLDADCRGNLKRIHAAFEAETGLHLRAGCEPEMMWLKADPDGKPTVEGMTKPYCYHIDQFSELQPLIHKVVDYGQKMGLDMIQGDHEDAPGQLELNFQFDRAELTADRLTTYRQICRQVGREMGAFACFMPKPFMGVSANGCHHNISLWQGDENMFLPDTDDPRMPGKVGLHAIGGVLEHLRGLCAITAPTVNSYRRYADAGFWAPIFADWGFQNRTTALRISAPGRFEYRSVDSAVNPYLSMAGLLTTIKDGLDRGLDPGQPEERNIYDAMKEGKQVQRIPSTLGEALDALEDDTVVRSALPGDMYKVFMHYKRDEWIRFISTVTDWDVKEYLDILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL4</accession>
    <name>A0A7K0JVL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ORF">GHK86_14835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000799">
        <property type="protein sequence ID" value="MST33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="31692" checksum="346D386337B43394" modified="2021-04-07" version="1">MTSAWGRGWTTVSDEGTALDTWYPELGLGDLPTAGDGGPPPAPDPLFGTSARLAELVIDLDAAPADVADAYLRLHLLSHRLVRPRTVNLDGIFGLLPIVAWTDRGPCPLTVVEAARQRARHEGAHFQVLGVDRFPRMVDYVVPADVRIGDADRVRLGAHLAPGTVVMHEGFVNFNAGTLGTSMVEGRISQGVVVGDGTDIGGGASIMGTLSGGGVEVVTIGRQCLIGANGGVGISLGDGCVVEAGCYVTAGTKVTWPDGTVQRARELSGRPGLLFWRNSTSGTVEVRERAGTWGALNPDLHTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVP2</accession>
    <name>A0A7K0JVP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_12820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000656">
        <property type="protein sequence ID" value="MST33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="23321" checksum="A283B45CDDE90F30" modified="2021-04-07" version="1">MATPVRVVLVDDHEIVRQGLKAMLARHTREVRVVGEASTVAAAVTAVETFKPDVVLTDLRLGAASGLDLARQLLGRWPELKVVVLTVYDDEQYVYQALRAGASGYLLKRVDGAELVRHLADVVAGQVVVDPTLAGRLAASAARLQHGEFWPGAHLGLSQRESEVLALMVAGLSNRAIAARLVVGEETVKSHASSVYRKLGVGDRTAAVATAIREGLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW6</accession>
    <name>A0A7K0JVW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03564 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000842">
        <property type="protein sequence ID" value="MST34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="311" mass="32578" checksum="D24E9FFC5F57D9DB" modified="2021-04-07" version="1">MIIGMHAAVGPDVGDPIGALVAEAETARSRGLALWMAQMFDLDALTALAVVGRAVPDVPLGTAVVPTYPRHPAALAAQALTVQAATGNRLTLGIGLSHRIVVEDFFGLSYAKPVRHLREYLEVLLPLLATGRVDYRGEEYRVATFAPVRVAGARPPAVLVAALGTQMLGVAGRMADGTALWMVGPRTIESHIVPTITKAAADAGRPTPRVCVGLPVSVTADPAAARERAARMFSIYNELPSYRAMLDKEGVGGPADVAVVGDEETVAAALRRLGDIGATELNLPVFGTDEERARTLEVLTALAAEQPRGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX5</accession>
    <name>A0A7K0JVX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_13300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000692">
        <property type="protein sequence ID" value="MST33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="298" mass="30310" checksum="6FBE9C64E858CFB3" modified="2021-04-07" version="1">MSRRALLLFAALGVIWGIPYLLIKVAVRDVTPATLVFLRCGIGAAVLLPLAAARGELRPALRRWPAVVAFAAAEIAVPFLFLPSAERTLPSSVTGLLVAAVPLAGIPIAWAFRRPQHLGTSGVAGVLVGLAGVAALVGFDLPRAELSSAALLAFVVVGYALGPAIVGRFLAGVPSLGVIVCALTLTTAGYAPAGILQWPARLGAAPLAAVVVLGVACTGVAFLVMFALIAEVGPVRETLVTYLNPAVAVALGVGFLGEAFTWATGVGFCLILGGSWLVLRRPAPAASGPTLTLESRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW34</accession>
    <name>A0A7K0JW34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000881">
        <property type="protein sequence ID" value="MST34170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="12931" checksum="73D26C9F4E21D2E6" modified="2021-04-07" version="1" fragment="single">MPDDEGMALHRAALAAAQAVPGPILEVGTYCGKSAVYLGAAAERAGTAAVSVDHHRGSEENQAGWEHHDPTVVDPATGRMDTLPFARRTLEAAGLEGRVVLVVGESATVAAVWDRPLAFLFIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW44</accession>
    <name>A0A7K0JW44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000852">
        <property type="protein sequence ID" value="MST34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="19394" checksum="95196F0994CB5E05" modified="2021-04-07" version="1" fragment="single">MDGGPIDRSSPVPLYFQIAENLRAAVAEGRLRPGDRLDNELDLCARLGVSRPTVRQAIQTLVQDGMVVRRRGLGTVVAARPIQRPLALTSLYDDLVTAGRRPATRVLEVTWREADEHAAAALAVEVGAPVVSIQRLRSAGGRPLALMHNELAAHWVEGLDVEAALAERGLYGLLRRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW73</accession>
    <name>A0A7K0JW73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000892">
        <property type="protein sequence ID" value="MST34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="91" mass="10123" checksum="95FEED20F672C0DC" modified="2021-04-07" version="1">MPNVLIRDVPPEDLERIRAAAAARGTSLQNYLLEVLRAQAGYLRRQEALARTAERLRGQPEVPDSERLAVLDAVDTAHAERADQLADRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW95</accession>
    <name>A0A7K0JW95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000873">
        <property type="protein sequence ID" value="MST34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="20404" checksum="4E0EA49C8F1A3379" modified="2021-04-07" version="1">MFTGIVEELGEVRAVEPAAVATRLVFEAPLVASDAAVGDSIAVDGTCLTVVDTGPGWWAAQAVPETLGRTTLGRLRPGDPVNLERPVRPDSRLGGHLVQGHVDGVGEIVAPAPDLVVRVPAGLVRYLVPKGSVTVDGCSLTVVDVTADAFSVAVIPHTAAVTTLGRKTAGDAVNLEADVIAKYVERLLGAGAVTPYGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG6</accession>
    <name>A0A7K0JWG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000930">
        <property type="protein sequence ID" value="MST34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="480" mass="49165" checksum="C671B011CB842BC1" modified="2021-04-07" version="1">MRREGQPAPSERVRTPAPYLRRRIPSGRGATEQPNVTSETAALTPRFWLAVLVTGVAAGLLGIAMMAILFTVEAVAFGGGPYLAAVERSRGWARVAPLLVAGAVAGPAWYLLRRFTKGQRSELDDALWSGDGSLSVRRSVGTSVLSELVIGTGASIGRESAPKLLGGLSGSVLAGPLRLTAEQRRLLVACGAGAGLAAVYNVPVAGALFTAEVLLGSIALPTVLPALACSGVATLTGWLYLHSHAVYPDVPAYHFEPAELVWALLAGPLIGLVAAGWIRLVAWVSYRRVGGRWAVAAPLAAFAILAAIGLRYPQLFGNGKDMANLAFLGDGTVGLFLVLGVLKPLVTALCLESGASGGLLTPSMSTGAVLGAGLGLAWSHLWPGAAAGAYGVIGGAAMLAAAMQAPLTGLVLMLEMTHSGFGIAVPVLAAVVTATVVARRIDGYSIYSGRLAPHERPARTLGPWNGASGHDAAPPPSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWI7</accession>
    <name>A0A7K0JWI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000941">
        <property type="protein sequence ID" value="MST34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="295" mass="31687" checksum="C4F335B00E3A3AFF" modified="2021-04-07" version="1">MAGTRRRVGVAMCPEFLREGTAIADFFAPPFTVIGAGDGEVAATLTDLLAVAGRPVHVVDPRTAEALKYACNAFHATKVTFANELGRIFRRYGVDSREVMRLFCEDDQLNISPRYLRPGFAFGGSCLPKDLRSLLHLARVANVDLPLLAATLQSNAVCVNDVVDRVVAGDGHTVALLGLSFKPDSDDLRESPSVDVAERLLGKGYEVRIYDPIINPTALTGSNRAYVQTRLPHLRRILTDTAADAVAGADVALVSSVHPAVLAALRAAPPPRLIDLDGRLGGDLERHPGYEGVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL4</accession>
    <name>A0A7K0JWL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000787">
        <property type="protein sequence ID" value="MST33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15664" checksum="26795B274CFA961F" modified="2021-04-07" version="1">MSRVNTYLNFPGQAEEAFTFYAKTFGTEITTLTRFSDLPGVGPGELPADEQHLVMHAELPILAGHVLMATDMLRSMGHEARIGNNTTLCLDVDSREDADRLYGALSDGGAEGSPMADMPWGAYWGVVLDRYGIRWMVNHTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP2</accession>
    <name>A0A7K0JWP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000801">
        <property type="protein sequence ID" value="MST33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="5808" checksum="901F0523DF08D436" modified="2021-04-07" version="1" fragment="single">MRLDGARVLLTGATGGIGRALADAFHAAGAELVVSGRRGAPLEELAAPVGARVVVADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ9</accession>
    <name>A0A7K0JWQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_16830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000974">
        <property type="protein sequence ID" value="MST34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="44"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="28324" checksum="ABF088A4384DF9D2" modified="2021-04-07" version="1">MAGRAGAAARRPARRPGAPRGRVPAPDRHRRRRGRVVRALAAQTAAELRLTLRRGESVLLTLAIPVGLLAFFSVVHVLPLPAGVHRPVQFLAPGILALAVMSTAMVSLGIATGFERQYLVLKRLGATPLGRPTLLAAKTLAILAVEVVQVVVLVGVALALGWSPGGDPAAAFGAVILATAAFAGLGLAMAGALRAEVTLAAANGLYLILLLIGGMVFPLSHLPGALADVARALPSAALSGALHATLTGGGPGGGAESWIVLAAWAVAAPVVAALTFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX28</accession>
    <name>A0A7K0JX28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000850">
        <property type="protein sequence ID" value="MST34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="128"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="547" mass="57441" checksum="B03E416DB1D08793" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA6</accession>
    <name>A0A7K0JXA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF459 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001082">
        <property type="protein sequence ID" value="MST34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007407">
        <property type="entry name" value="DUF459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04311">
        <property type="entry name" value="DUF459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="251" mass="26633" checksum="36B01AED5EB6A444" modified="2021-04-07" version="1">ATAPAPDPHPRGWSGARCALSLASRPAPAPVGRCTVLEIGDSLGNDLGWGLQRHLSPASGFHLIQADVSSTGLVDRSFYDWPAHLATDLHRYHPQLVLASLGGNDEQGMVIDGSVQAFGSPAWQRAYLAKVTALVREATDGGAYVLWVGLPVMQQPGFSAGIATLDTLDARAVAADRYATYLSTWELFSRPGVGFAADAEVNGASAQIREPDGVHYAYAGEDVVATYVIRHLAASFHVRLAPQHPAVLTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC8</accession>
    <name>A0A7K0JXC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000889">
        <property type="protein sequence ID" value="MST34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="182"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="270" mass="29225" checksum="851A10316FB81B9D" modified="2021-04-07" version="1">MSPGDRSHWHRRRSSPHRCRSTCSKHPAPSARPRPSAHRRCPCSIHPRRRHATMTDNGLAERSLVAAGNIRAPLRSGPPSLPEARTGVPQADLDDEPEVHVVGSNSNRTVTLARVADVGDEVSGSHCTPDAAATGARSVQPLTAASARSELATAHPRQRAHSAFADPLDEHRRTPSRKFIVPEALDLSNAPTFLRALCRAIDQAPDGIDVDMASADFVGVAGWRVLLHSARYAAGRAPFTLSGLSARHRRTAELLGLTEALRRLEQRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE6</accession>
    <name>A0A7K0JXE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001106">
        <property type="protein sequence ID" value="MST34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="264" mass="27234" checksum="51282A4EB4EC806E" modified="2021-04-07" version="1" fragment="single">MPRDPLRGAGAPWRTGDVWAISASAFFADLGYQAVLAGFPLFLVLTLHQPVWEYGLASALSYGGGALFSYAGGRIGDRVGHRRLALAGNAVIPLLSLCALVASPVWAIGMLTGGWWARNLRSPSRRAMLVDAVPVDEHRSAAFGFLHALDVGGGALAGVYVLAALAAHVPFRWIFLATVAPLAVSTLSLSRAQVGSRRAPDDPGSLGIVGGDDVEAAPPGAKALLAAAALYGFTYYSAGFPVLTVAQGSGRVLAGLGAFLLLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF3</accession>
    <name>A0A7K0JXF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000902">
        <property type="protein sequence ID" value="MST34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5289" checksum="C5B424FA064B77F9" modified="2021-04-07" version="1" fragment="single">MATSLALTLAAGPSRAGSWVAAVGVPCLGARAAAELGVDLDRLVLVPEAGEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF4</accession>
    <name>A0A7K0JXF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001110">
        <property type="protein sequence ID" value="MST34626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="12989" checksum="D5B59B8CCB861628" modified="2021-04-07" version="1">MGEQPDSVAAFVAATEDLLAVLDQLSAERRPLARRAQQVRKQLAGGRSLTDVVQAEEPPLIVATLRESTARFTDAFSRFQRAEARALHDEGMSMERIGRLFGVSRQRVAHLVEPPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXH1</accession>
    <name>A0A7K0JXH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001123">
        <property type="protein sequence ID" value="MST34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="13790" checksum="7CD14CCEBBDE0A42" modified="2021-04-07" version="1" fragment="single">MTPEGGDAPAQQPEQVPKIEDIKITVSWTQVVASAAAAVTAGLVSSFFGVAGTIVGTLLASVIATTGSAVYNANLRRTQHRLRTARARRAFAAQAARAEIRGASVGSPAPAADDPPPSEPSAIPDPPDPPTGGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL0</accession>
    <name>A0A7K0JXL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001149">
        <property type="protein sequence ID" value="MST34687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="33475" checksum="481B69F450CFB2D1" modified="2021-04-07" version="1" fragment="single">MTDTAVPVTTKKDWTSDQEVRWCPGCGDYSILTAVQMLMPELGVRREDTVFVSGIGCSSRFPYYMNTYGMHSIHGRAPAIATGLAVTRPDLHVWVITGDGDALSIGGNHLLHALRRNVDLTILLFNNQIYGLTKGQYSPTSEPGKITKSTPFGSLDHPYNPISLALGAEATFVARTHDMDRKHMMETFRRAHAHRGASLVEVYQNCNVFNDGAFEQITARDARPHMLIPLRHGEPIRFGPDGERGVVIDEGGARVVEVAEVGVEALAVHDEHREDPSLAFTLSRLATGPYTPTPIGVFRDVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN2</accession>
    <name>A0A7K0JXN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001169">
        <property type="protein sequence ID" value="MST34710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="20741" checksum="F011FA60BA32F201" modified="2021-04-07" version="1">MAAPAGPGGPAPGPVRFAGGDCTRLPFRAGSFDAATARYLLQYFPDPVEVFRELARVIRPGGVVCVIDVDDAFSVTHPELPAPVPRLMEAFADLQRARGGDRQVGRKLPGALDAAGFQVASIQLVSQAGYGASSPGDLSRRFLLRRLEPAAAEIVERGLATEHEISQALEVLRRVHLPPMTAIEAQLAVLARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP1</accession>
    <name>A0A7K0JXP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001176">
        <property type="protein sequence ID" value="MST34723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8303" checksum="0A675AC2D1C2D542" modified="2021-04-07" version="1">VAGASDLGALLVAGGEPRHAPIVTVHDAASHALAWLGSAVGAPTVPLGFDEFGQSGSIEELYGRLGWLPDQIATAALTAIATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR5</accession>
    <name>A0A7K0JXR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">o-succinylbenzoate synthase</fullName>
            <shortName evidence="3">OSB synthase</shortName>
            <shortName evidence="3">OSBS</shortName>
            <ecNumber evidence="2 3">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">menC</name>
        <name evidence="5" type="ORF">GHK86_18680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="2 3"/>
    <dbReference type="EMBL" id="WJHE01001187">
        <property type="protein sequence ID" value="MST34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03317">
        <property type="entry name" value="NAAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01933">
        <property type="entry name" value="MenC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010197">
        <property type="entry name" value="OSB_synthase_MenC_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073:SF5">
        <property type="entry name" value="PTHR48073:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01928">
        <property type="entry name" value="menC_lowGC/arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="142"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="369" mass="38898" checksum="687B7294095DD3F9" modified="2021-04-07" version="1">MELTGVELRRVRLPLVSPFETSLGVDTERDALLVRAVTPDGEGWGECVAGIDPTYSSEYVEGAQDVIRRFLLPILASRPWSSAGEIATLLAPIKGHPMAKAAIEAAVLDAELRAAGIPLAAHLGAVHRRVAAGVSVGIMPTIGELLDVVAGYLEVGYRRIKLKIKPGWDLEPVRAVRERFGDVALQVDANAAYRLGDAARLAALDPFDLLLVEQPLPEDDLRGHAELARRIRTPVCLDESVTSARAAADAIALGACAVVNIKPGRVGGLLEARRVHDVCAANGVPVWCGGMLETGIGRAGNVALAALPNFTLPGDTSGSDRYFRTDLTAPFVLDDGHLAVPDGPGIGVAPLPEVLEEVTVSAEWVPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY67</accession>
    <name>A0A7K0JY67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4388 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001278">
        <property type="protein sequence ID" value="MST34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="2">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="270" mass="30135" checksum="3E1E840166DA8B23" modified="2021-04-07" version="1" fragment="single">MMLPPHPISQPARRRPESSSAVVARVWIGARLGRRRTAMPLQGTFDVLDFTEVLHLLSQQELTGRLHVRSRSFGAHLFLEDGLLVGADQSEHQPAATAGDVRGRIEEVCFEMLEAERGSFEFHAGKPSTLPVGERFKTDEVLAQARRRLDEWHELQELIPSLDLQPRLVLDLSRTEVTLDRERWRMLTTIDGRRNLRAIGRALNLSDFDVCRVLRTLLEDGIVQLDGYASLPASTRDAMPVVPAPDSPGLERVTPVGGDDAETVAFPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB1</accession>
    <name>A0A7K0JYB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <ecNumber evidence="4">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="9" type="ORF">GHK86_17525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001047">
        <property type="protein sequence ID" value="MST34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="25969" checksum="EB08704924B9D34D" modified="2021-04-07" version="1" fragment="single">MATPFDGDGRLDLDGAARLARWLVGQGNHGLVVSGTTGESPTLTDGEKAQLWQAVAAAVDVPVVAGTSTADTAHSLELTEAAVAAGVAGILAVTPYYSRPSQAGIEQHLRAIKAAAGDLPVLLYDIPVRTGRKVAPEVIVRLAADGVLAGVKDATADPAGSAALVAAAPAGFELYSGNDGDTLPLLAVGAVGVISVESHWAAPEVGEMIGAFRKGDVDHARAVNARLLPSHRFQSSDEAPNPVPTKAMLRVLGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYF7</accession>
    <name>A0A7K0JYF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop NTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001073">
        <property type="protein sequence ID" value="MST34569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="17963" checksum="6763007C19D3205A" modified="2021-04-07" version="1" fragment="single">MPPGRLRRPSPTTEPGRPVEPRAFCSQSNVVIVAGKGGVGKTTVAATLAVTAARSGLRTLLVDVEGTGALPALFGRSAPLDYRSVTLVPATHGRGSIAARAVTSDDALVEYLDDHGLRRVSKRMATTGTLELVATAIPGIKDILVLGKVKQLEQSGPARSRPGSGPGPGTPEPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP8</accession>
    <name>A0A7K0JYP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001134">
        <property type="protein sequence ID" value="MST34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007709">
        <property type="entry name" value="N-FG_amidohydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05013">
        <property type="entry name" value="FGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="29897" checksum="425AB07EBB8322E1" modified="2021-04-07" version="1">MASCSGTGDGGDAGGPLLRETVTSGVHVRPPLGAARPFVASIPHGSDLIPQRFASQMLLAEGLRSDAYTPEVYGFVAELGATVVEAALSRYVADPNRDLAAPTFGPFPRGIVASTDGWRPLYADDLPPDAVAERIAVAHTAYHRALDEALASHLAATDRVLLLDLHSFGVPLDTDVVLGDAHGSTAPGEVVMLLQEALADAGFRVTRNRRFTGGWIVRRFAGVAAVDAVQVEVNKRLYADEAAVADRRRQVPRDPDRIGVLRERLRAAFGQALGAYEAWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT0</accession>
    <name>A0A7K0JYT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001382">
        <property type="protein sequence ID" value="MST35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="10861" checksum="068792BBA467A2C4" modified="2021-04-07" version="1">RFPIDVVKLDASIVRDSERDAGQGLILDSVTALGEGLGLQVVVEGVETTAQLGRLRAAPGRPLAQGYALAPPLPPEALTELLVRGVGDQAGATGVPAVADRPDSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT3</accession>
    <name>A0A7K0JYT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AHS2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_20615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001446">
        <property type="protein sequence ID" value="MST35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="12940" checksum="6070BACC5632F381" modified="2021-04-07" version="1">AAGSATVAVVPGPRSDRLGPGGWEVLVAADWTVAPTSNRVGLRLTGPRLPVLAGEVPPEGIATGAVQLPPGGRPVVFLADHPVTGGYPVVAVVAGEAGLAALAQLRPGAAVRFASASPVPRYLKDRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYZ5</accession>
    <name>A0A7K0JYZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001493">
        <property type="protein sequence ID" value="MST35178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="81" mass="7919" checksum="C4B8C9AB03CC885E" modified="2021-04-07" version="1" fragment="single">MTLATNALRAGPLAASQPGFTIVDPLIAATVGVLLFGERLQTGAGDLAIEIAALAVLGLGAWGLSRSALVGGGDPGVPEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ21</accession>
    <name>A0A7K0JZ21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001221">
        <property type="protein sequence ID" value="MST34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15625" checksum="61F0B223BFB6ADE4" modified="2021-04-07" version="1" fragment="single">MSGPTRRLLVARHGRTAWNLAGRYQGHADPDLDDEGRSQAARLAAELTGRVAERLVASDLRRARDTAAPLAEALGIAVLVDKRLREVDVGAWEGLTAEEAAERFPDEYAAWRAGEDVARGAGETRQAGGARAAAAILEHAREVPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ96</accession>
    <name>A0A7K0JZ96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EscV/YscV/HrcV family type III secretion system export apparatus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flhA</name>
        <name evidence="7" type="ORF">GHK86_21505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001593">
        <property type="protein sequence ID" value="MST35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="364" mass="39182" checksum="EB571B5786244BAD" modified="2021-04-07" version="1">AEPAATDLPPAPPPDSPEALARDMRVDPLELEVAFDLVELVDASRGGDLLERVRALRRKMALDLGVVIPLVRTRDNIDLPASSYAIRVLGAEVARGEAHPGQVLAIGEHLEGLPGMVTTEPVFGLAAKWVPLALRAQAEMAGATVVDPTSMITTHLAEVVRKHAGRLLTRSDTKALVDMVKRNDPTVVEELATAQVSLAEVQRVLRDLLDEGVAIRDLGRIFEVLTEKVRTTRDPEALVEACRQALGPTIAASYALDRVLPVITLHPSIEQMLMESLKSNDAGTFLAVEPSRAEQLVLTVAQRAQEAEQLGDTPVLLCAAPVRPALRRLVHTAAPRLPVLSYAELGSELRLETKGVVELGHATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC8</accession>
    <name>A0A7K0JZC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001585">
        <property type="protein sequence ID" value="MST35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="107" mass="10698" checksum="A7AD33E7F5591500" modified="2021-04-07" version="1" fragment="single">MGTQRTRVAAEAEEPVRRSVAAGSVRSAPGTGTAAGDPIGHLQRSAGNRATAALLRAGQAKLEVGAADDAYEQEADRVARQVVANLRAGGAGAGAPELDGGAAPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF1</accession>
    <name>A0A7K0JZF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ORF">GHK86_19800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001325">
        <property type="protein sequence ID" value="MST34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="36540" checksum="5959E2B87BD9A12B" modified="2021-04-07" version="1">MTRILSGIQPTGGVHLGNYLGAVRYWVEDQRIGESFYCVVDLHALTIPRDPAELRQETRAMATLLLAAGLDPEACTLFVQSHVPQHTQLSWLLECTASMGELRRMTQFKDKAAKGGEEAARVGLFTYPTLMAADILLYRATHVPVGEDQRQHLELTRDLAERFNTRYGPVFTVPEATIPPPGRGARIMDLQEPTRKMSKSAESDQGMIGLFDEPKVVERKIKRAVTDTDDGPDAVRFDPDTKPGVANLLQILAAATGGDPAEVATGYRRYGELKAATAEAVIELLRPVQARYRELEADPATVDKILRAGAERAEPVAAATLARAMDAIGLLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZH8</accession>
    <name>A0A7K0JZH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001676">
        <property type="protein sequence ID" value="MST35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="14299" checksum="A150FBD16EF981BE" modified="2021-04-07" version="1">MLAFRDRLRRFLAWSEAQAKEAGLTPSQHQLLLAVRGHPAPEPPTIGEIAEHLQLRHHSAVGLVDRAEAAGLVRRVPDDADRRVVRVVLRPAGADALDELTALHVTELAVLAEASAAFRSPQPSATAERAGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZQ2</accession>
    <name>A0A7K0JZQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001392">
        <property type="protein sequence ID" value="MST35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="96" mass="11181" checksum="CD50626A9E4DB64C" modified="2021-04-07" version="1" fragment="single">MSERVVWELREQVAELRAELAEAAQREQERERELAALRHELELRIARDAANEERVTIARSQLEEVRGHLRWLTGHTDAVTERFDEARQALAALRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMY5</accession>
    <name>A0A7K0JMY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_01120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="123"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31622" checksum="17662D86C1732E50" modified="2021-04-07" version="1">MGAARPAPVHSARRPATVAAWSRPASARCRPFARPGRTWPVVGVVPWRTNSTSVAGGSLGRLEGGIPGQPSVWPVAFPPPLAALEDEIVRCRACPRLVAWREEVAATRRAAFRHEVYWGRPVPGFGDPDARVAVVGLAPAAHGGNRTGRVFTGDRSGDWLFAALHRAGFANQPTSVSRDDGLELTGAWVAAAVRCAPPANRPTPEERDRCVPFLERELALLGQVAVVVALGGFAWDVCCRLEGIRPKPAFGHGAEARSDRSGRTLLGCYHPSQQNTFTGRLTEPMLDAVLARAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN51</accession>
    <name>A0A7K0JN51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000035">
        <property type="protein sequence ID" value="MST31307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="11130" checksum="D6ED5EE23016F4C8" modified="2021-04-07" version="1">MQEPRPARASAVLRQHRSAVLDAVRGCRGRRVRVFGSIARGEDGPDSDIDLLVDFEPDSSLFDLLHLARQLEDLLGRPVDVVSAGGLKDRDRLILTEAVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN65</accession>
    <name>A0A7K0JN65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3097 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000057">
        <property type="protein sequence ID" value="MST31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="29610" checksum="766DAD12910A58F8" modified="2021-04-07" version="1">MARGEQPPTRGAGRGILSGPVDGPWRAGRQLRTVPAERGLRVTHLGSRFTGTVVRFEGNAVVLRSPNTGLERLFTLRAGSFAIGKEPVDLVKPAPVGGGAGEPGLTASGSVAVTPGRARVARAGRILVEGVHDAELVEKVWGDDLRVEGVVVERLDGVDVLADVVAALSPGPDARLGVLVDHLVTGSKEWRLAQEVQGAHVLVTGTPYVDVWQAIRPAVVGLDAWPVVPRGRPWKAGICEALGEPEPGRLWKRLLGSVRSYADLEPSLVGAVESLIDFVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNA8</accession>
    <name>A0A7K0JNA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_01640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000066">
        <property type="protein sequence ID" value="MST31435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="281"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="537" mass="57243" checksum="05FAEE8074823B33" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNC2</accession>
    <name>A0A7K0JNC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_01605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000065">
        <property type="protein sequence ID" value="MST31428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="15774" checksum="A82012C3BD2049BA" modified="2021-04-07" version="1">KARQQQGGRSNLEVGDDVISAGGILGRIVAIDGDEIVVEVGPGTTMTFWRRAVNLRSSVAGAPPGSTMAPPPPPPEEPVDDHYGVDHRYDDGEDGTGSEPSGHFGAPEEPADGAADADGGPPQPIYDPGAHPSSDPWGASPQGEGTESSGSPEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNC3</accession>
    <name>A0A7K0JNC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000051">
        <property type="protein sequence ID" value="MST31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="223" mass="23171" checksum="0668E2A8A81797E3" modified="2021-04-07" version="1">RHIAAHLLEASPADIVAGADGLHVAGVPDRAVSWGALAVASRDADRLPEGLEPGPLRHEGDFDGGNSTFPFGAHVSVVEVDTETGGVRIRRHIAVDDCGRILNPLLVSGQQHGGIAQGAAQALFEWVQYDEDGNPLTSTLMDYLVPAASELPSFEASNTETDSPRNPLGAKGIGESGTIGSTPAIQNAVVDAVSHLGITHIDMPCTPERIWRAVTSAGVPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV4</accession>
    <name>A0A7K0JNV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="88"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="368" mass="38840" checksum="3264A6EDFF200F89" modified="2021-04-07" version="1">MPRWTLASEPRAERSSVGRTPPGVGRDATSARSGPPRRDRPAAAVGLGRVRSPQSRRGRCSRMARRTACGRAAGAGRGGALVTVIEIALAYAARGWPVFPLEPGGKRPLGRLVPHGLKEATADATVVERWWRQEPQANIGLVTGQHFDVLDVDGPEALDAVSAAMPLAERPEEDPYLRGPQVATPRGWHAYIAPTGRKNTVNIAGIAGIDWRGQGGYVVAPGSVKTEGGSWDWICGPEDPEYGVDAPILPAPAWILELFERRTQGRRGAPVAPLRGGREGTSAYASAALEREIGRVAMAGEGARNHALNLAAFALGQLVGAGLLDTRTVVEHLHVAAQRAGLDDIEARATIRSGLAAGVAQPRTRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP26</accession>
    <name>A0A7K0JP26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbB</name>
        <name evidence="8" type="ORF">GHK86_03100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="WJHE01000123">
        <property type="protein sequence ID" value="MST31716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="35843" checksum="8C81BC28FF4B0458" modified="2021-04-07" version="1">MHLLVTGGAGFIGSNYTRWVLEHTDDHVTVYDALTYAGNRSTLRDVEERWPDRFRFVQGDVCDREAFEAAARGCDGVLHFAAESHVDRSIAGPDAFVLTNCLGTNTVMQACRDLGIGRVLHVGTDEVYGSVEVGRSREGDPLAPRSPYSASKAGSDLIALSYHSTYDLPVVVTRSANNFGPWQYPEKVIPLFATNLLDGGRVPLYGDGLNQRDWLHVEDNCAAVDLVFRRGTVGEIYNVGAGAEITNRELTERLLALVGAGPDRIEMVADRLGHDRRYALDTSRIRALGWSPARSLADALADTVQWYRDNRWWWEPLKSMTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP34</accession>
    <name>A0A7K0JP34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="402" mass="42701" checksum="AAB70A01500FB38F" modified="2021-04-07" version="1">MRPLEDVRILALEQYGAGPFGSVQLADLGAEVIKIEDPGSGGDIGRYVPPFQEEEDSLFFETFNRNKRSISLDLANPTGRQIFEDLVAVSDVVYSNLRGDVPDRIRIRYADLAHRNPAIVCCSLSGFGTTGPRRAEAAYDYIVQGIAGWMELTGEPDGPPAKSGLSLVDYSGGLVAAIAILAGLHAARRDGSGMDCDVSLFDTALGMLTYPAVWYLNGGPAPARTAHSAHPSLVPFQAFATADGWVVVACPKQKFWRRLCTAIGHDELAGDGRYADFAARSAHRAELVAELDAVFATRSSAEWLEALASAGVPCGPVNGVAAALADPQTAARGMVVETDHPRFGRVRQVASPVRVGDEQPTYRRAPRRGEDGGRVLGRLLDLDAPAVDELAARGAFGAEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP60</accession>
    <name>A0A7K0JP60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="11097" checksum="D280773827EDB4E8" modified="2021-04-07" version="1">MAQVIVQGEFVVDPGDRERFIEASTERMRSSRAEDGCLEYVFASDPLEPGRVVLSERWASMELLRRHLDGQASRPAADRPETISAEIVIYEVTSATKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC7</accession>
    <name>A0A7K0JPC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000061">
        <property type="protein sequence ID" value="MST31409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="236"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="321" mass="31166" checksum="938712B66A7BACFC" modified="2021-04-07" version="1">MAAAAHDITPSLVDLDTALSYEGLQAAGTGIVFGRGGLVLTNNHVIEGETSLTAVDVATGRRYRGVVVGYDMASDVAVVRLVGAPGLPVARFAPGSAHLGQQVVAVGNAGGRGGTPTAAGGTVTGLDRSITASDQGGGTVEQLSGLISTNADVQLGDSGGSLVDAAGQVLGVDTATLRGVAFSGTGHEGFAIPIDTAMGIARRILAGRGSAAVHVGPTAFIGVRASASSCSAGAPGTSVSQGSGALVCDVIPDTGASAAGLVPGDLITALSGFPVRTPASLTHLLVERFHPGETVTVSFRGADGRGAGRGAAVTLGSGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI9</accession>
    <name>A0A7K0JPI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="19754" checksum="BE6B651BD893DF79" modified="2021-04-07" version="1">MLYAFGFETVGVVVGDLYFIDPHPEPGQEGPERGVRLEVRLLARQELHGSIYSAQPIVIDQPVWRADLLESVDTAPGSFDRTHHHPRFVGWEPGKRQFEQAMSGDPVAFVGAQLEDLPALLERARLDPSSVPEADVEALRGTIPEILDTTRRLLDRVWAGELARPPAETADSARVGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM3</accession>
    <name>A0A7K0JPM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginine deiminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000085">
        <property type="protein sequence ID" value="MST31504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20478" checksum="2B1994D19C62C33E" modified="2021-04-07" version="1">EGGDIHVLGHGAVLIGMGERTTPAAVEMVAGALFAGGQATVVLAVELPRSHAFMHLDTVMTMVDVDRFVVYPYLDPDFRAWRLTPGDGSQIRTERLDDLWSAVAQALGTDKVGLLVADEDLRAAQREQWDDGTNFLAVAPGVLLGYERNVTTNTMLRRAGIEVSTVSSSELGRGRGGPRCMTCPIRRDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPT3</accession>
    <name>A0A7K0JPT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfatase-like hydrolase/transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000186">
        <property type="protein sequence ID" value="MST31972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="463" mass="51003" checksum="A7EBEFB412B39D43" modified="2021-04-07" version="1" fragment="single">MGLNEYAPGSAFPGVIGRTTDESTPAWPRPLRAAPWAPNVLIVVLDDTGYGQLGCYGSPIATPNIDALAAGGLLYTNMHTTALCSPSRSCIVTGRNHHANATACVNELATGYPGYNGNIPFENGFLSEMLLAQGYSTYMIGKFHLLPSEYESAAGPYDRWPLGRGFERFYGFLGGDTSQWYPDLVYDNHQVAAPATPEDGYHLNADLADRAIQFIADAKQVAPHKPFYLHYCTGATHAPHHVPKEWADRYRGQFDEGWDAYREKVFARQKQLGLVPAHAELSRHDPDVPRWESLAPGARKVAARMMEVFAGFLSHTDHHVGRLLDYLRETDQLDNTLIMLVSDNGASAEGGATGTTNELQFFNNAQESVEETEAAIAALGGPTTFNHYPWGWTFAGNTPFRRWKRETYRGGTSDPFVVHWPHGIKARGELRHQYAHIIDLVPTVLEAVGVEPPLTIRGVTQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPV5</accession>
    <name>A0A7K0JPV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000190">
        <property type="protein sequence ID" value="MST31988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="33047" checksum="CABD571D833947CA" modified="2021-04-07" version="1">MGPLVSVIVPTRNRSELLTRAIASVAAAAERYPSVEIVVVDDGSDVAVDERILASESDVSARVVRRSRPAGPSAARNAGLDAAAGDVVCFLDDDDTVHPDALRDTVAFLQQRGQAACSAWHAVVRPDGSSGTFRAPVRAEARTLRWFDVIAAPFACIDRTRAGTELRFDESLPACEDWDLWLRLAQRAPVPVLARPLYRYHQHAATRVTRTGTNAADGRRAFLAKHGGSMSASCRRYHEAVIALLDGDRRRAVRTAASSPQAALMLAATYGSARVGLTRSDPGAPARAVARITGSPALLRHRRRAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX7</accession>
    <name>A0A7K0JPX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000184">
        <property type="protein sequence ID" value="MST31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10753" checksum="1D03774A916B045B" modified="2021-04-07" version="1" fragment="single">MTAGLPEGDEALAALADRVLELVAGRGEAAVSVAHVREGLTRFANSFIHQNVGDEHVSVTLDLVVGGRPASASTTGLDDAALRRLVEAALAAAAVQPVDEDWPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ07</accession>
    <name>A0A7K0JQ07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Relaxase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1187" mass="126567" checksum="DE25CC1AD0660754" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ10</accession>
    <name>A0A7K0JQ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000193">
        <property type="protein sequence ID" value="MST32001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="226" mass="22786" checksum="25D32646FD34509F" modified="2021-04-07" version="1" fragment="single">MSGSLRVASDLEVIRVDIGTGERAAAAVHERCVPSVVGIGRRPGRGTGVVVDPGVVVTNAHNLRGATTTVRFADGREATGTVAGVDGDGDLAAITVDTGGARPIDWADGDPDPAVGQVVFGLGALPEGGARLTVGTVSATGQAFRGPGGRLIPAAIEHTAPAAPGSSGGPVVDREGRLVGLNTHRLGDGFYLAVPATDDLHRRLRDLARGQSPTRPRLGVALVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ22</accession>
    <name>A0A7K0JQ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="14813" checksum="A2BB368660763B79" modified="2021-04-07" version="1">MRDPKPGTAWSVGRARRRAAYAAWMTSAGWARQRDAWLAEWARRHPGRPPVCAACGEAWDPRRGDLHHRDYRRLGTEAFSDLIPLHRSCHDQLHQLLERAARPPRTRRAQASDAVLTHLRSTHRSTPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB4</accession>
    <name>A0A7K0JQB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation_ATPase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000223">
        <property type="protein sequence ID" value="MST32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation_ATPase_N" evidence="2">
        <location>
            <begin position="548"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="661" mass="67307" checksum="0146F415018AF666" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD3</accession>
    <name>A0A7K0JQD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_05355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000225">
        <property type="protein sequence ID" value="MST32152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="274"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="372" mass="38963" checksum="B881A8EBF0DBE4A0" modified="2021-04-07" version="1">MSFVELVLHNVTVKPLRLALTALAVAIGMVTVVSLGVVTNSLKNTDLALLRTGRADFTVAQKSVADLLSSSIDAATAARVARTPGVADLTGVLIGTTRLNASNPQFLEIGIQPSQLEAFGVTVVSGHAFGASATHEVLLGYIAAEDLGLHVGGTLHLDHTAYRVVGLYSTGQSLGDAGVMLPLTTFQTAQRQPSQYTLLFVRVTPGSAVQTVQDRIDSAFPQLATIRTIEQFGRADRSLSLILAANRGATILAVVIGAVVVMSAMSLTFVERTREFGLLSALGWTRRRVGTMILAEAVMIGLVGAAGGLALAVLAVLAIQHLPVLIGVLHPQYTFPVFLRAVLTALAMALLGGLVPAMRAAIAEPLEALRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ6</accession>
    <name>A0A7K0JQQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="372" mass="38366" checksum="6F870027E20548DF" modified="2021-04-07" version="1">MIGFGEVVTYGLAVLAALANATSSTLQRRANRDEPDDVAFTPRIMLDLLRRPVWLGGILAVIAGFLLQAGALSRGNLAVVEPVLTLELPFTLGLASVVFKARLRVREWTSAAVLTGGVVLLLIALSPRGGSSAHVPLYEWCIGLAVNLGAVGILVARGLRAGPAARAALLGVATGAMFGLTAALMTRMSVGFASGVVGALTMWQTYAMIATGGAAMYLLQNALQAGTLVAVQPGLTLTDPLVSIIWGVIVFHEHVNGGLWYLVAIVAGGMLILGTVWLSNSPLIHGQQQPGGEQAGGEQAGEGRPSGGRPGREHAGEDQTGSNRDGEGDTEGDPQRTGHPDGACEEEGSADERRRLSLDDPTETPATGGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR10</accession>
    <name>A0A7K0JR10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="469"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="692" mass="74891" checksum="1F15DC21BF3910CB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR60</accession>
    <name>A0A7K0JR60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCA tRNA nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_06720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="269"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="463" mass="51464" checksum="592E41B45EE14A4B" modified="2021-04-07" version="1">MIPERLQPLVTETAPLAARFEAAGRRLYLVGGVVRDAVLGRLDPDGDLDFTTDATPDEIERIVAPVAAAVWTQGKRFGTIGLRLGERTLEITTHRAEAYHPDSRKPDVVFADAVEADLSRRDFTVNAMALALPGLQLVDPFDGVDDLAAGRLRTPLDPEVSFTDDPLRMLRAARFIAGYGLTPDQALVDAVVTLRSRLDIVSDERIRDELDKLVVVPRPGEGLWFLVRTGLAEEFLPELPALALEQDPIHRHKDVLAHTIAVVEKTSPDRLLRLAALFHDIGKPKTRSFGPRGTVSFHHHEVVGARMTRDRMRALRYPNDDVDTVSRLVELHLRFHTYRMGWNDSAVRRYVRDAGPLLDRLNELTRCDCTTRNAAKAAALSRRMDELEARIGELREREELAALRPDLDGVAVMARLGVPPGRVVGEALAYLLELRLEEGPLGEEEAGRRLDAWWAARQASGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR92</accession>
    <name>A0A7K0JR92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000298">
        <property type="protein sequence ID" value="MST32455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="59"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="545" mass="56874" checksum="56D505D386E8C057" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR93</accession>
    <name>A0A7K0JR93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_06995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000303">
        <property type="protein sequence ID" value="MST32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="40"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="3">
        <location>
            <begin position="420"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="546" mass="60304" checksum="98D6553E3B873C5C" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI4</accession>
    <name>A0A7K0JRI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_07375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000325">
        <property type="protein sequence ID" value="MST32542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31248" checksum="3940292A1B4EB333" modified="2021-04-07" version="1">MIDPDVLAQRFEAHREHLRGVAMRMLGSRHEADDAVQEAWLRLTRTDADAVDNLGGWLTTVVARVCLDILRARAVKQEVPADGRWEPRVGASAEDEALLADAIGLALLVVLDTLAPAERLAFVLHDMFAVPFEEIAPIVGRTPAAARQLASRARRRVQADPAVPDAPTETHRAVVAAFLAASRQGDFAGLIRLLDPQVVLRADAVAVDMAAGRASAGAPPLRGEMRGVDAVARVFAGGARAARLTLVDGLAGAVVSVGGRPMAVFGFVVLDGRVVTIELTADPATLAVVELGPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRM2</accession>
    <name>A0A7K0JRM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_07660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000338">
        <property type="protein sequence ID" value="MST32598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="14"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="489" mass="51101" checksum="DDA2041A07C5ED4C" modified="2021-04-07" version="1">MGDGARTGRGNGWGLLVVMTGVLITAVDTTIVVLALPEIERDLKVGLGSVIWVVIGYLLVITLLATQVGRLGDMYGRVRMYEAGFVVFILGSALCALAWDPAAIVGFRLLQGVGGAFVTANSGAVIADLFPREQRGRAYGYNAVGWSLGAVLGIVLGGAIVTYLSWRWIFWINVPIGLLAVGVAFKVLREQGERRRHRIDLVGMGTFGLGLFGILWAVTRLAATALDTALVGFLLGGVLLLAVFTIVERRQAEPMLDLSLFRIPTMTPSLLASLFQGLANFAVLFLVIMYLQGPRGLSPIDASLLLVPGYVIGGFVGPVAGRMTDRVGPVLPATVGLGLEVVALFFYAHLSLHTGLWLVVLASVVNGIGASCFFPANSSAVMKASPPQVFGISSGMLRTSANVGMVFSFSMAILIASRSISRGLAFAIFVGSTSLHGRLAAAFTTGLHAAFYASMALMAVAAVCSATRGARRAGGGRPTPVAPGTTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRN6</accession>
    <name>A0A7K0JRN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000253">
        <property type="protein sequence ID" value="MST32244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="220" mass="22490" checksum="AFCF3B1672E18A44" modified="2021-04-07" version="1">MAFTVGAAAWLAAWGWLVRHGASPLWVDTQATAALAAGKQVQDEGIRLLTVEGPAGAVVAAVGLSLLAVGFRSTRGAFAVLAGVALEVTSVQWVVKPLVGRHELAPGYSFPSSHVGAVVAVATSASLLVSRRGPVGRSLRPGLGRLVRWLVAAAGAGDVALVGAATITTGGHLFSDVVAVIPWAVAVPWLTFALMVPPVAEPGGPERRRPRTHRAAVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX6</accession>
    <name>A0A7K0JRX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000363">
        <property type="protein sequence ID" value="MST32692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="14"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="34878" checksum="549811F5CF4D2B23" modified="2021-04-07" version="1">MQSRHLGSLEVSALGLGCMGMSEFYGQGDDDESVATIQRALDLGCTFLDTADMYGPFTNERLVGRAVAGRRDEVVLATKFGNERLPDGSWVGINGRPDYVRSACDASLGRLGVDHIDLYYQHRVDPDVPIEETVGAMAELVEAGKVRHLGLSEASPATIRRAHAVHPITALQTEYSLFTRDVEAEVLPTVRELGIGFVAYSPLGRGILTGAYTQSSDFAEDDSRRAGRFPRLADANFERNRALVAAVEELAGRKGCTPAQVALAWVLAQGGDVVPIPGTKRRRYLEDNIGAADVALDAAEAAALADRIGVPEGDRYADMSTVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ2</accession>
    <name>A0A7K0JRZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000368">
        <property type="protein sequence ID" value="MST32718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="488" mass="53163" checksum="9C05FCC964328639" modified="2021-04-07" version="1">MEILAAYDLTKTYESAGRLAGVDPKTVKRYVELRDTGVDVFARPARPKLIDPFMPKIEELVEESKGRIRADVVHERLVAMGFAGDERTTRRAVAEMKDAWAAGRRRVYRPWIVEPGRWLQFDWGKGPQIGTRPTNLWCAWLAWSRFRVVIPTWDRTLPTVIACLESTLRRLGGAPTYVLTDNEKTVTVDHVAGIAVRHPQLVATARHYGVSVHTCVPFDPESKGGAEATVRVAKADLVPTDANLLAGYSSFAELAAACDGFCEHINARAHRETRRPPVDMLAEERAHLHAIPADAYTAAFGETRRVNRSSLISVGGVRYSVPYQLIDQTVWARFDGDDLVVVHAGPDGAREVARHRRSTPGRARIRAEHYPPRGGDPIARHAKATNKTEAEFLAIGPGAERWLVEAAATGASRVKAKMADAVALAKLHGAGRVDRALGTAALVGRFDQADLAALLAADNATTGTGLHADEAHSLQAGTGAWARFGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS94</accession>
    <name>A0A7K0JS94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000396">
        <property type="protein sequence ID" value="MST32812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="368" mass="39481" checksum="B20B52D10A14754B" modified="2021-04-07" version="1">AMDLVARVAPPAADGELLEGLRVAQARLHALGITHWQDALIGEAGEIGVLDTYGAYRRAAEEGWLTARVRGALWWRRDRGLEQIPDLLGRREGSPDGAFRATSVKMMMDGVCETFTAAMSRAYLGDAGKGGTHRGSLFIEPEVATAAVAALDEAGFQVHFHAIGDRAVTTALDTLEALPEHRRGAGRHHLAHLQFIAPDDLDRFAALGAIANFQPLWASHEPQMDDLTIPVVGEERAGWQYSIASLAQRRARLAFGSDWPVSSPDPIQEIHVAVNRMLSLRMGRPGRPETEQPFRPEESLPVADAIDAFTAGVAYVNGDEDLLGALTTGRRADVAVLDQDLFAIPAAEIGDTSVALTVAGGAVVHGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSA8</accession>
    <name>A0A7K0JSA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_08725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.27" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000394">
        <property type="protein sequence ID" value="MST32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PTHR10430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16410" checksum="CB88AD729ABCC32B" modified="2021-04-07" version="1">MTIAVGDRLPDVEVHVPTADGPKRVRTGELLGSGTAVLFGVPGAFTPTCSDYHLPGFVLRADDLRTKGVGTIACMSVNDAFVMGAWGDAREVGDSVVLVADGSADLTRALGLELDLSGGGLGVRSQRFAMILQDGVVRDLAVEAGTGLDVSTADAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSC7</accession>
    <name>A0A7K0JSC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_07010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000303">
        <property type="protein sequence ID" value="MST32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="200"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="391"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="597" mass="64938" checksum="C9E229078AC5E5C6" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSE5</accession>
    <name>A0A7K0JSE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="46" mass="4876" checksum="D6C375DAD2CF3F6E" modified="2021-04-07" version="1">MDQHPLAALLAAWDAAYGPVPEQAATDATAAFDDLDAYGERSTDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSF9</accession>
    <name>A0A7K0JSF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000413">
        <property type="protein sequence ID" value="MST32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="416"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="513" mass="54505" checksum="BD0BA4E1D7EB3F0A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN0</accession>
    <name>A0A7K0JSN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_09415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000436">
        <property type="protein sequence ID" value="MST32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="178"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="349" mass="36431" checksum="5EEBF73938409A6E" modified="2021-04-07" version="1">MHALVYRGPGQRAWQEVPDPRLEADTDAIVRVDATTICGTDLHILKGDTPEVAPGRILGHEAVGTVEAVGPAVRRVGVGDRVLVSCITSCGTCRYCRQGRYGQCLGGGGWILGHLIDGTQAESVRVPFADTSTYPAPSGVGDEALLMVADILPTGYEVGVRNGCVQPGDSVVVVGAGPIGLSAILSAKLYTPARVIAVDVADNRLEAAKRFGADVTVNDGREDAAAVVQELTGGLGADVAIEAVGVPDTFELCTRLVRPGGHVANVGVHGRPATLHLETLWIRDVTITTGLVDTSSTPMFIELLSGHAIDAAPFVTHHFGLDEFELAYDIFSDAADTGALKVVLARARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS0</accession>
    <name>A0A7K0JSS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000449">
        <property type="protein sequence ID" value="MST32992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7792" checksum="1C1F66EC07D8EE8A" modified="2021-04-07" version="1">MWGKRSRRRSRPERADAGPEDEWGPCEYLDDRGRPPSEEDDAEAARNWRAARHGRPEDWPSRPAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY6</accession>
    <name>A0A7K0JSY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000363">
        <property type="protein sequence ID" value="MST32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="187" mass="19804" checksum="786449CC85468BD9" modified="2021-04-07" version="1">MGRTYDGIDDRLAAWLEAQPVFFVATAPLDPAGHLNLSPKGNRHELAVLGPRRVAYLEQTGSGIETVAHLRDNGRIVVMACAFEGPPRIVRLHGQGRAVRPGTPEWPAVAGALSERGCDPGGAGVRSAVVVDVTRIADSCGYGVPVMSFDRHRPTMDEWAARKGAAGVIAYQAASNRTSLDGLPALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT03</accession>
    <name>A0A7K0JT03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000475">
        <property type="protein sequence ID" value="MST33082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="12227" checksum="53606E50B46C56CD" modified="2021-04-07" version="1">MARAAKRALGYRWHLRRLMADQDMYATTDLGPLLAERGVVLSAAQVYRLVTGTPERLSLRTLVALCDILGCSPADLIEPVVEPARSRAVATGTDTAALKTRTPRRADVGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT58</accession>
    <name>A0A7K0JT58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_10425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000496">
        <property type="protein sequence ID" value="MST33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="514" mass="52498" checksum="5167AA226C6F2E76" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT62</accession>
    <name>A0A7K0JT62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000500">
        <property type="protein sequence ID" value="MST33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="3">
        <location>
            <begin position="222"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="427" mass="45960" checksum="E73B70B4A30FE27D" modified="2021-04-07" version="1">PRRPDRPRSDNGVLPSRYVERRPPTRPTPRNRRRRRLPRALLVIPTLVLVIASWALIGAATTPGNQSYTAKVADWMRSHDMAFITNNAERVLYNFEKPPKGGRPKHLNALPATGGSAGPARSSSHTAQAVVAHLPAPSPVPLVVHPALPGEGQWKPVGPTVDGYPGMYESQFRADTVYTSELTTAVWIDPKLMKLSLIPGQGEPGGTWPHPPYITHAELPTIAAAFNGGFRFADAHGGFYLDGRTAIPLRKGAASFVIYKNGHVNIGAWGTEVKMTPNVVSVLQNLVPMVDHGVVSPTATYNDVSVWGATLGASTVVARSGLGVTKDGALVYVAGPYLTARTLAESLQRAGAIRAMTLDINPEWVTFNFFGHPNPSNPYQVSSAAIYPQQQRPSTRYLGPTLENRDFIEVRTPTPVTAATSGSSPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE5</accession>
    <name>A0A7K0JTE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="16889" checksum="B378A7AFA475AFEF" modified="2021-04-07" version="1">MLAAHGGFAAAGNGSPANWTIYDFNYTPGVTYHVADSYGLDSSYNQVPITAPKFVVKDASQARLTAAHRSGATVTLSGVTAQFLQSANFGEGAVAAHPERVVIQRQTGKKWQTVRIVRSNLRGRFTARFTAWAAAVYRAAIPGTPRMVTSFSPTRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTF8</accession>
    <name>A0A7K0JTF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="113"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="143"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="366" mass="38233" checksum="690E7880590E03E0" modified="2021-04-07" version="1">MSSPTVTGPERGCDTGGTAGQYDPVPDAFPVRRRALVTAPLRGPGLERLRALADVVHEPWLDQQPLRIYDAAGLADRLAREDATIAVVESDLVAGPVWDLPLVAVAATRGDPNNVDLPGATAAGVPVLHTPGRNADAVAELTVGLLIAATRGIAVADREVRGGEVFRDGTIPYQRFRAWELAGRRAGLVGLGAVGRAVRWRLEALGMEVIACDPYQPDAEVSLAELLATADVVSLHAAVTGETRGMIGAEQFATMREGAVFVNTARAALHDTDALVAALQGGRLAAAALDHLEGEMLPAGHPLLELPNVVLTSHIGGATYDTEARGAAMIAEDLERLLAGERPARLANPEVLGTPAFAERLAGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTG2</accession>
    <name>A0A7K0JTG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fuculose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="22879" checksum="E6FC9006390BFE62" modified="2021-04-07" version="1">MSGAPSSAPTAGKVLHTAKALLRKGLVEGTAGNLSARRPDGLIVTTPSAVDYEAMTLDDLLVVDLDGNVVEPAAAPGRSPTSELHLHLACYRAYDDVQAVIHAHPVWATMFASARQALPACIDEFAMYVGGDVRCAEYGQSGSEALAANAVAALEGRGAALLANHGLVAVGPSPAKVLHIVALVERVAQIAWGARALGGPVALPEQAQTDFAGVYEIMRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH4</accession>
    <name>A0A7K0JTH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008634">
        <property type="entry name" value="Gas-vesicle_GvpO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05800">
        <property type="entry name" value="GvpO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="225" mass="24473" checksum="BE528600DD5DF415" modified="2021-04-07" version="1">MPRCSTRKASFATSAVAGARPLVIRLLLRRRFGRERPLLADPAGARGRGCYRPERGLPRDGGTAPTTPPARRRLGRWSNHSRTCWPGPTAPATRSGNCSSSSPPSGRPSRRRPPRRTRRSRACARRFARPRRRCARPARPKPASTSPVRCGPPPTCSPGRAEPLPGRRGSGAAAPPSALPGAVELERVPATTSVLASYEAELDEEGTLLGYGRLRRYYRNQADPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS0</accession>
    <name>A0A7K0JTS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000560">
        <property type="protein sequence ID" value="MST33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022526">
        <property type="entry name" value="F420_Rv3093c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03841">
        <property type="entry name" value="F420_Rv3093c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="33697" checksum="6E73682290EC7AB8" modified="2021-04-07" version="1">MTVPFQGVPLAEHRSWFAEASELGYTDLWSSEADGTDAFTPLALAAAWAPDLRLGTAIVPAYTRGPALLAQSVAAMAEAAPGRFAFGLGTSSDVIVERWNDTAFDRPYQRTRDLVRFLRLALGGERVDEEFETFRVRGFRLGRPPAQVPPILVAALRPGMLRLAGREGDGAIINWLAADDVPRVVAEVGPGREVVARIFVCPSEDTATVRAHARRLIGAYLTVPVYAAFHEWLGRGEALQGLWDGWAAGDRKAAVASIPDAVVDALVLHGSPAAVRAQVDRYVANGVTTPVLALLPMAGVEQRTAMRELAPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT3</accession>
    <name>A0A7K0JTT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000451">
        <property type="protein sequence ID" value="MST33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="291" mass="32316" checksum="0DDEC17CF9F05905" modified="2021-04-07" version="1">MSPTVTATAVDAPPARRPGRRRLRRSGLAALRWGAAALFAFPLYWMWVTATGPKGSAYRFPPRILPGLDYQAFVTVIQGTNWARYMLNSTFITGTTILLVLLTASLAGWALVALPLKFRGVVFIVLLGTMLLPEQALLIPQYVVNYHLHLLNTYAVMILPFAATSSSIFLFRQYFASMPTEWRDVARIEGLGNLRYLWRVALPAAKPVVFTVVLLTFIASWNQFQWPLVMTQNPAIAPIELALNQYQQSYESQRLINAVSLLALLPIVLVFAVAQRHIVSAVAGVDSGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTY7</accession>
    <name>A0A7K0JTY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000582">
        <property type="protein sequence ID" value="MST33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="15167" checksum="258B5DB53359C2BF" modified="2021-04-07" version="1">MPELNGTKTHDNLKEAFAGESQANRRYLYFAQKADVEGYPDVAALFRSVAEGETGHAFGHFDFLAEVGDPVTGVAVGDTEDNLKSAIEGETYEYTEMYPGFAKTAREEGFDAIAEWFETLARAEKSHAGRFSAGLESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ2</accession>
    <name>A0A7K0JTZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mreD</name>
        <name evidence="10" type="ORF">GHK86_11870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000583">
        <property type="protein sequence ID" value="MST33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="232" mass="23754" checksum="DC46EEE543948923" modified="2021-04-07" version="1">DGGLPRRHPGRSHHRREHPPGGDRTGRQPASPGGPHPAGLRRHPALVGSVTAATIARIRIVVLLLVGIVVQTTFASDLRIGGVAPDFMLLLAIAGGLTTGPAAGAVIGFFAGLLADLSLTTTPLGLFALAWCLVGVIVGWARSNILPEGRPVEPFVGLAATLGGVAIFLAGADLAGQSAVLAPGARWLMRVALIEAGWNTVLAIPAAWLMRRAARGSRGADRLGRTDALASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU03</accession>
    <name>A0A7K0JU03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3987 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000474">
        <property type="protein sequence ID" value="MST33074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="247" mass="25906" checksum="7507F2EC3B8739B1" modified="2021-04-07" version="1" fragment="single">MDAETAHSATGDAARPDPNHDEAQLLAPPPGWPDPPAETVWSGLAGTIAAALAPHTEADPLAIMVQLLVAAGATIGRGAWVEVGATRHHPNQFALLVGDTAKARKGSSWDHVESVLTAAEPSFAGVVHTGLSTGEGLIWAARGDGQRLLVVEPEFVTVLMATARDLSTLSPVLRAAWDGRPLAILTRTSPVHAPRAHIALIGHITRAELGGHLHAIEAANGFLNRFVFLAVRRQRLLPEGGHPNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU11</accession>
    <name>A0A7K0JU11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000592">
        <property type="protein sequence ID" value="MST33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="268" mass="28294" checksum="C4986426F0ECC75E" modified="2021-04-07" version="1">MTAHVSVRVVVRALGAGRRASARGAVRRLAARATCAVAIAAMAPVLVAAPAFAGNVTLGSGQRLSSGQSLKTGSSCYDLDVQATDGNIVEYCGQSAVWSTNTGGHAGDYLIVQASDGNVVAYTSGNSPLWSTGTSGYSGDILKLQTDGNLVVYKGTTPLWARSWIQSPSDAQTYAPELFQGYSWSVSSQKGCLTDLWNQESGWEWNATNPSSGAYGIPQALPASKLASKGTDWKTDGLTQVQWGLSYIKSTYGNPCGAWSHEQTYGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU70</accession>
    <name>A0A7K0JU70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000615">
        <property type="protein sequence ID" value="MST33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="164" mass="18227" checksum="A67F1A842A1780FB" modified="2021-04-07" version="1" fragment="single">MELHPLLRWRMARSRADDLGGPAQRQRQRAWRAAHRDYLAAVLAEVTERGPVAASALSDPRRRSGEWWDRRSIGREALELLFADGVLAAWRTPSFERVYDLAERVLPTAVLARPTPEPEAAQRELLAVAAGALGVATLPDLADYFSLRPATARPRVAELVEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB5</accession>
    <name>A0A7K0JUB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000634">
        <property type="protein sequence ID" value="MST33546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="8055" checksum="5D542D5F04B9259D" modified="2021-04-07" version="1">MRKLAQFLVRRGMRVGWRRGVVQGNRAWVVVGGLALLGNLAGRALAKQEDVVFREEIRAGETFEVVHRPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ0</accession>
    <name>A0A7K0JUJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000648">
        <property type="protein sequence ID" value="MST33583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="59" mass="6843" checksum="EE92B0966C9786B1" modified="2021-04-07" version="1">MPSGREVVRKRVTDLVHGDVTLEYGRVTHREGRKVWFESRVVTFNSVDDELRVDTSDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUJ5</accession>
    <name>A0A7K0JUJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Phosphoribulokinase</fullName>
            <ecNumber evidence="3 5">2.7.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphoribulokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.19" evidence="3 5"/>
    <dbReference type="EMBL" id="WJHE01000656">
        <property type="protein sequence ID" value="MST33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008974">
        <property type="term" value="F:phosphoribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006082">
        <property type="entry name" value="PRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00478">
        <property type="entry name" value="PHRIBLKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00567">
        <property type="entry name" value="PHOSPHORIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="6">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="36589" checksum="429AD1393C7603C7" modified="2021-04-07" version="1">MPHKVLRIRRAQVDPPTRPVMLAIAGDSATGKTTLTKGLVEALGPDRATSICVDDYHRYDREERRHLPFTPLNPECNYVQIMEQHLQLLATGHPILKPVYDHRTGSLVRPALVEPREFVIVEGLLPLSTRLARACFDVAVYLDPPEAIRHQWKIKRDCNDRGYTPEQVVAELERREPESAAFIRPQREEADIVIRFAPIEGRQDPPGTPLSAEVALRPTIRHPDISRVLGEEHHAMHVKLARDADGRPIDALHVHGYASREDSRVLEKAIWEQLEVDHPFPESLGRLGGAQRSEPLAIAQLLLLYHLLDNRPDRDLTALVPATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT5</accession>
    <name>A0A7K0JUT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000697">
        <property type="protein sequence ID" value="MST33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="14771" checksum="ABA85E13D35737CB" modified="2021-04-07" version="1">MSPGPAPIPATHRDLLDSPVATLATVGADGRPQVSEVWFLADDQTVRISLNTARQKTRNLRADPKCTLFILDLANPYRYLELRGDAELEPDPDYRFADRVGAKYGSDLRAHDGPGESRVTVTIRPARVNAVDMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY5</accession>
    <name>A0A7K0JUY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000719">
        <property type="protein sequence ID" value="MST33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="37565" checksum="9CD5087D1A473091" modified="2021-04-07" version="1">EDGESRSRGDWAIGEARYSALLTDRELLGVDAGQLHQRGLDAYEALSAEMAELARQIDPDAGGWVPLLARLDAECPSTPEEMRAEYERWCTLARDFLAERELVSFPEGERCLVVPSPVFQRPVLAVASYQEPPPFSASRVGHFFVPYPPEGESPEGIAERLASNGYHAIPTTAVHEAYPGHHWHLVWSAQTRRPVRKVVTTSYFVEGWALYTEVMMRREGFFTDPRVVLSHLGARIFRAARIVVDTALHTGGMTPEEAVTFLQEKVAMTRAVAVAEVERYCSWPTQAASYLTGSLQIEALRDRWLAEGRGDLHAFHDAVAADPGLPVALVERRLFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY9</accession>
    <name>A0A7K0JUY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10988" checksum="604ACD154B9EC4EE" modified="2021-04-07" version="1">MAETCTHLGTVRDVTPSSDGCEDCLRSGDRWVHLRLCMSCGHVGCCDSSANRHATAHWNAHHDHPLIRSFEPGEDWWWCYPDQLFFEVDGAAPAPSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV14</accession>
    <name>A0A7K0JV14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14735" checksum="E810968AED2AC48F" modified="2021-04-07" version="1">MGRVAGFRFISATVPDLDAALRFWCRGLGLRLDERGTAKTVGGARFEWARVQLPRGCTIVLRTPPVADAETSGGAVEHPSAPHIGLEVVGLADVLAQLQMLGYDPVPGDDPGGPAVDAEHPSTLVISPDGLLIELAEVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV16</accession>
    <name>A0A7K0JV16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">potA</name>
        <name evidence="10" type="ORF">GHK86_13525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000703">
        <property type="protein sequence ID" value="MST33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="382" mass="40293" checksum="6DCE95ADCA4E3CEB" modified="2021-04-07" version="1">MSGGTVELLHVSKRFADVVAVDDVSLTVSPGEFFSLLGPSGCGKTTSLRMIAGFEYPSSGRIVLDGADVTDTPPNRRNVNTVFQSYALFPFLDVAGNVGFGLRYTNATKAEVTRRVGEALELVRLSGYEKRRPNQLSGGQQQRVALARALVLRPSVLLLDEPLGALDAKLRRALQVELKALQEHVGITFVFVTHDQEEALTMSDRLAVMSGGRVVQMGAPQDVYENPATAYVADFLGVSNLLAATVARAGSASAPCELRIGDVALESRCGAVGESGSVRLAIRPERVVVEPAGTGGANRVPVIVERTVFLGSAVQIHLRLATGESLQALVPNDGTELAWTSGSPAQAHLPADALRVLAPDHDEAPVPSAQGVDAFDVPLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV65</accession>
    <name>A0A7K0JV65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000739">
        <property type="protein sequence ID" value="MST33831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="48"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="19492" checksum="3117F0FD6A1E15A6" modified="2021-04-07" version="1" fragment="single">MRAGQLPGVRMFGEAIGRVGDAILGAGSVDAFCEQLVAGPLAEGDALVVLGSTLVVWSARPTAAEAPGLWNAPQLDGGWFVGGASNAGGLWLSWVERSLAPGSPLDAHPRRVPVWLPYIRGERVPRHQPERRASLADVDLLQGPAELRRAALEASAFVVRSLLERAGPLPRRILATGGGSTARPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV91</accession>
    <name>A0A7K0JV91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaD</name>
        <name evidence="11" type="ORF">GHK86_14300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000760">
        <property type="protein sequence ID" value="MST33885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="5"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="537" mass="59339" checksum="BCFC9B31FE5E9BB9" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVC1</accession>
    <name>A0A7K0JVC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1778 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000599">
        <property type="protein sequence ID" value="MST33449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014795">
        <property type="entry name" value="Vibrio_phage_ICP1_Orf50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08681">
        <property type="entry name" value="DUF1778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="9638" checksum="06B95AF5F7887064" modified="2021-04-07" version="1">MSAKSRRREMRADPDAEQTIAAAARLGHQSVSAFVLGAALAEADRVLARREVTLMAAEQFDALASSLEAAEPAPKLAQVAERTRSFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE8</accession>
    <name>A0A7K0JVE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YggT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000774">
        <property type="protein sequence ID" value="MST33926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9552" checksum="A4DB0EE9443805B5" modified="2021-04-07" version="1">MLSGPPLYILGQIYVLIMVIRAVFSFFPYSSDSPLNPVRRVVTTLTEPVLAPFRRLIPPVGMFDVSFIVAFLVIEVIVQTVLIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVI9</accession>
    <name>A0A7K0JVI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000793">
        <property type="protein sequence ID" value="MST33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="176"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="381" mass="41634" checksum="23D401D782B3347E" modified="2021-04-07" version="1">MKGSTRKRGSTWTAMWSTTDPGSGQRLQHSKGGFRTQKEAREHLNAVLAKVAEGSWRPDRRITVRQLLDDWHAAKVSEGLGPNTAAMYRTVIDSWVVPHVGGLRLDQLTPAVAGRMVEELRSPTGSRHGRGALSGRSIQLAVQCLKSATRWAAETGMVSRDPLQGFKRPKAKATSDATGAWDAAEARQFLASIDDDRLRAAWWLLLGRGLRRGELAGLRWSAVDLEAGVLRVVETRVVVQAKAVSSLPKTDGSRRSVPLDDRLVAELRAHRARQAEERLRPGAAWQDTGFVFVDELGAPYRPETFSRTFTRLATAAGLRPIRLHDLRYTAATLMLASGENVKVVAEILGHSSPVVTQTIYQHVLPGQGRAAGERLSALLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK9</accession>
    <name>A0A7K0JVK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000799">
        <property type="protein sequence ID" value="MST33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="116" mass="11802" checksum="B10E6860AB750497" modified="2021-04-07" version="1">MSEPSLSDREQAILAGLAAQAEADDPRLAQALRRGPRLLLARLPVLPSPLAHWTVGLLAAVVGLAACVVLLGVSVVAALAASVLLFAGVGRVVAAGPWRRRSVSPPTPDSTQPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVM6</accession>
    <name>A0A7K0JVM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000800">
        <property type="protein sequence ID" value="MST33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="85"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="226"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="483" mass="51342" checksum="F2ADA57E41C381D6" modified="2021-04-07" version="1" fragment="single">MPVTPASGPAGALAAWTADADGFGSNDVAFLETVASILAAALSRRHVEAQLRRQAVHDELTDLPNRVLLQDRLETALARLGRRGGSVAVLFVDVDNFKLINDSLGHTLGDSVVAAIADRLRAAVRSRDTVARFGGDEFVVVGEDADAAVARRLAERIRQELAAPLSIAGKTITVTASIGCATTSDPAASPDSVMADADMAMYEAKRAGKNGVAVFTPELRRRTTDHLETVSGIRRGLEAGEFRLHFQPIVDLTTGRAHGHEALLRWHHPTSGLLLPAQFIDYAETSGLIVPLGRWVLDTGCAQSAAWRRAGRPSKVSMNVSGWQLTGSDIVADVAAALGASGADPADIDLEVTESALISDLDQARSALEGLRELGVGLGLDDFGTGWSSLSQLARLPFDFVKVDRCFVRDLETDQRTAALLESILTLCATLGLDVIVEGVETASQLDHLEDLDVRWVQGFLLGRPVPPALVDSGPPAVLARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ8</accession>
    <name>A0A7K0JVQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyl-gamma-aminobutyrate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000820">
        <property type="protein sequence ID" value="MST34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="10564" checksum="2CDB566F8B306FAA" modified="2021-04-07" version="1">DDHARFGGDRHARVHDVSLDPDSLAASVYGTTLRVNSLHHQAVDRLGGGLVVAGRSPDGTVEAVEMPGRAVLAVQWHPESLAGDPGPAWLVAAAGGGQRNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX2</accession>
    <name>A0A7K0JVX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000694">
        <property type="protein sequence ID" value="MST33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="15080" checksum="3F4D38EE22E32945" modified="2021-04-07" version="1">MRIGELAARAGTSVKTIRYYDRIGVLRPERRSEAGYRLYDEDALDRYRFVRATQAIGLSLGEIREVLALRDRGETPCGFVIDLIGRRADELDARIAELVALRDELSELRQRAARLDPRDCDPKLVCHVIAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW29</accession>
    <name>A0A7K0JW29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000873">
        <property type="protein sequence ID" value="MST34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="157" mass="16223" checksum="49069DB2A74BD78C" modified="2021-04-07" version="1">RWITGPLARADVHALRAESGAVAVGAGTVRADDPSLTVRDAEGPDPLRVVVGHVPPGARVAPALEHTGPLEDLLDELGRRDVLQLLVEGGPRLAHAFHAADLVDQYVVYVAPALLGGDDGLPLLAGPGAPTMAAVRRGRLAGVRVVGADVRIDVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW54</accession>
    <name>A0A7K0JW54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000889">
        <property type="protein sequence ID" value="MST34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="340" mass="36909" checksum="BEE8F90D990EEF49" modified="2021-04-07" version="1">MPITPIPAVALRPVAYFPKGSFLENLAVRSDGSVLVSSLLHKELWCVPGPEPSLDVEPVVVQTFDNIVMGIVEVEPEIFIVSLSDGYTTHESHLARIDLNGWAPGMLVSPEIIYTFDYRARALNGSCLLAPGVMLIADCFAGHIWRIDLDPGAHHARARIWTEHPTMGMDLDSEVAPPPQPGINGIHYGPKTGYVYYTSTAQQVFMRIRVDPATLEPAGYPEFVAAIDKTDDFCIDEVAGFAYVTRHRGNTIDRVPLAPGHGSEVRHIVGDPFDDRLVGPSSAAWGRNPNHPGRVAYVTVDGGRTAPPPDGIIRDAALLRIELQPAPVEEAPAYATVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD5</accession>
    <name>A0A7K0JWD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multi-copper polyphenol oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_15870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000890">
        <property type="protein sequence ID" value="MST34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="38" mass="3798" checksum="55867A740378E5E8" modified="2021-04-07" version="1" fragment="single">MFPLLGGFPVDVVVTTRVGGVSAGPYAGLNLGLHVGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWL6</accession>
    <name>A0A7K0JWL6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gmd</name>
        <name evidence="6" type="ORF">GHK86_16655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="WJHE01000955">
        <property type="protein sequence ID" value="MST34345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="8"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="36076" checksum="119AD860551AC631" modified="2021-04-07" version="1">MATSPTALITGITGQDGSYLAELLLEKGYEVVGLHRRSSTVTFERITHLMDRITLVPADLLDEASMIRVLRDFEPAEVYNLAAQSFVQTSFIQPVLTGEVTALGVTRILDAILLTNPGIRFYQASSSEMFGKVVEVPQTERTPFHPRSPYGVAKTYGHWITVNYRESYGLHASSGILFNHESPRRGLEFVTRKVAFSAAAIKLGLQQEVRLGNLEAQRDWGYAPDYVRAMWLMLQQDGPDDYVISTGETHSVRELCEVAFGHLGLDWERHVVVDEQFFRPAEVDLLIGDPKKARTVLGWEPAVGFEDLVRMMVDADLASLSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY7</accession>
    <name>A0A7K0JWY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000979">
        <property type="protein sequence ID" value="MST34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="46" mass="4759" checksum="FB86439CA9BD4712" modified="2021-04-07" version="1" fragment="single">MTDYRLLVDGSWVEGASGAHREATSPGHGGAFATVAWGERADAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX22</accession>
    <name>A0A7K0JX22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001041">
        <property type="protein sequence ID" value="MST34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="25838" checksum="106DA331D2CA9372" modified="2021-04-07" version="1" fragment="single">MNLTLTRRGDYVVRSALALARAYPSGRPRKIREVVAEMAVPPTFASQILADLVRAELATSRAGKAGGYRLVRDPRDISLLEVVEAGEGPLRAERCALGDGPCRWDAVCPLHETWSSATAAFRSSLAATSLADLAASDEGLETGTRSAPADSHRAGGHAVAVDQTVPVAAPAATLLDRLHRLEPRLAAAVAAAYAEVLPAGGGWHPGEADTAVVLAAQPRAATGTLTWECASEAEDGESRFEGAVEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX90</accession>
    <name>A0A7K0JX90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="194" mass="19489" checksum="E0A3FE423294B024" modified="2021-04-07" version="1" fragment="single">MARGLQPLRYRGFRRLVGGQLASNLGDACYAVALPWYVLAHHGGPVLLATVLAAYGVPRTALVAVGGAAADRWRPWTVMLLADAFRAATVGVLAVAAWSGPPRAAVLVPIAVVLGAGEGLFLPGSLAVIPRLLPEADLQAGNALGSAGTQLATLVGPAIGGVVVALAGPAVAFAADGTSFVVSAVSLLGVRRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX99</accession>
    <name>A0A7K0JX99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_17825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001075">
        <property type="protein sequence ID" value="MST34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="358" mass="37669" checksum="C0272FE336398EC8" modified="2021-04-07" version="1">MEGMPPRRGRRFRWSVPLGRVAGIRISVHLSFLLLVALVVAYPGPLGIVGGLVWIVIVFACVVLHELAHSVVAQARGGRVHAILLLPIGGVSQIERLPEGWVNELLVAAAGPAASLLIAGLAALAAVGFGHDLLPIDLARGPVTTRLLWINLLLAGFNLLPAFPLDGGRILRAALEPRRGVEAATRAAATAGRVFGGLMIAAGLLWDLWLVVIGVFVILGATQEQTVTEAHLRLQGVPARVAMRAPAATLDARWPLPFPHSGGGPWPVTLDGRYLGMAREHDLTASTHGTVADVTDTTVEPLRPDEDLGRTGLDKLIAADGQTLPVVDGGAVLGVVRIADLGPWLERPTLGAGPPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ4</accession>
    <name>A0A7K0JXJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001140">
        <property type="protein sequence ID" value="MST34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="34"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="32268" checksum="A57DDBE5E483DE4A" modified="2021-04-07" version="1">MRVLVTGSSGFVGSWLTEHLAAIGDEVLTLPDEVDIRDRSALVDAVRAAAPEGICHLAGQASVKDSWDDPSTTYAVNTIGVAHLLDAVASCSTPPRVLLVSSAEVYGRVPPEELPIGEDRPFAPPSPYGASKAAAELIGLQAWLGRGTEVVRARPFNHTGPRQRPDFVVPALARQVVEAASGPGELRVGNLAARRDLTDVRDVVRAYRLLLEHGESGGVYNVCRGTSVPISEVLDRLVRLAGVEVRIEVDPARLRPADVPDLRGDPRRIETATGWGPELDLDRTLADVLADAERERARALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL4</accession>
    <name>A0A7K0JXL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001154">
        <property type="protein sequence ID" value="MST34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="16891" checksum="6134CEEE420C6195" modified="2021-04-07" version="1" fragment="single">MTDDTLPEHAPYVIIGAGIHGLSTAWHLAEQLRVTGRGSGADVVVIDKGEIGSGASGIACGVIRNNYFQPAMRELMAHSVSVWESDPEAFSYHPVGYMQLGPDVMGDDVAQIAKEQEAIGYPSQLVQGADDCRRHMEGLFSDWQAQGITVVLHEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN3</accession>
    <name>A0A7K0JXN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_18600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001177">
        <property type="protein sequence ID" value="MST34725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="352" mass="37961" checksum="A540B11B93C1B76A" modified="2021-04-07" version="1" fragment="single">MTMTDKTMVDDGADGGVDPSRTPAGLALSLEDGLVDQLMAQVRAGGVELLGEGGVIAGLTKKLLERALDEELTEHLGYERGDPAGRGSGNSRNGTTPKRVLTELGAVDLEVPRDRNASFEPTIVPKGATRLPRFNEAIIGLYAGGMTTRDIKKALKRLYGIDVSPDLISRVTDGVVEELREWQNRPLDAVYPIMYIDALVIKVRTGGTVINRPAYLAVGVDVAGRKHVLGVWLGDGGEGAKFWLAVLTELKARGVADVLIVCYDGLKGLPDAIEATWPSASVQTCVVHLIRASLRYCSWKDRKTVVGALKPIYTAVSAEAAADALDTFELEHGDRYPAIVALWRAAWERFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXQ0</accession>
    <name>A0A7K0JXQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_16445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000936">
        <property type="protein sequence ID" value="MST34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="183"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="28032" checksum="4D5DF18B00AF3C75" modified="2021-04-07" version="1" fragment="single">MSSVKVSAAAPSEEALVRAHLPLVHYAVAEVAGRVPRHVSRDDLTSAGMAGLAQAARSFDPERAISFSRFASTRIRGAILDELRSRDWASRSVRAKAREVGAAADRLTGTLGRTPTTKELADHLGVDPTDLDDLNCDVQRSVVLNLDDLGPTGSGDEAVLAGELGPDAQLLERERQAYLVAAVANLPERLRRVVMGYFFEELPMHVLAEELGVTDSRISQMRAEALVLLKEAIDAQLEPATESPAPAPRPATRGKVDGGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX7</accession>
    <name>A0A7K0JXX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_18690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001188">
        <property type="protein sequence ID" value="MST34742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="34676" checksum="433087D6EEB75CBF" modified="2021-04-07" version="1">MPKPRVQTPNEDLVHLYLRDIGQHQLLTREDEAELARAAEAGRAARVELATAGALISGERASELRRTVERGDRAVETFVNANLRLVVSIAKRNWGSGLPLLDLVQDGNLGLMHAVEKFDWRKGFKFSTYATWWIRQAMSRGVANAGRTIRLPVHAAEFLARVTNARTRMEAELGRRPSINELALDLDVGVDRVIEILRHAGPPASLSSPVHHDSDSELGDAIQDHAAISPPDAALTALLPLQIGRMLSCLTDRERQVLRLRFGLDRGEPLTLEQIGLDFGLTRERIRQIEARAFSKLRHPSAGGDLRDLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ1</accession>
    <name>A0A7K0JXZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_19025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001226">
        <property type="protein sequence ID" value="MST34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PTHR37536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="327"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="489" mass="49841" checksum="54E610A1E803C768" modified="2021-04-07" version="1" fragment="single">MRRSSGGPSRFGLGPARAGAGRRSGRVVSLALLPAVLAMVGMSAARSPATPAARLHVVGPAAAGRAPLIDLRGRRSAPARISGVRLPATGARAVPFRRPLRRRMVTGEATNASSSTNWSGLVMTGTGIQGAEGAWTVPAVAGAVGTDSATWVGVDGASNSDLIQTGTAQTPGGGYSAWWEILPAVSVTITDAAGSPAPVRPGDSILASVQEVHAGTWTIYIADQTQGWYFQQNFSYSGPGTSAEWIEEAPTDNGQQTAPADFGTVDFSDTGVYEGSGSSPGWYATDLTASNEIDMVNATGTHILAAPGSPSAPSGNGQAFRDSYILPPSSPTGLTGSWTGSGIYLTWAPPSDTGGLPIQRYIVERQAPDGSSSTVGTTTGTSLTVGGAMPGAAYTFAVVAENAGAWMSPSSAPVTVTTVSSSNPVPTSSSPPSTSPPVTEPAPVPAPTVRLSSPTSGLQLGDWIVVRYTSPNTPAALFRVRYADVSWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ4</accession>
    <name>A0A7K0JXZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03668 family PPOX class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001247">
        <property type="protein sequence ID" value="MST34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019967">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv0121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03668">
        <property type="entry name" value="Rv0121_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="16427" checksum="4C20BBA16500A2CF" modified="2021-04-07" version="1">MTPEEARRRFVAARVARLATTGPDGRPHVVPMVFAVDGDTLASAVDHKPKRTQRLRRLDNIAADPRVAVLVDDYDEDWGRLWWARADGSARVVAPGSAEGRRLVDLLVARYAPYRERRPEGPTLVVEVERWSGWSAAEGSRGATLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY10</accession>
    <name>A0A7K0JY10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001258">
        <property type="protein sequence ID" value="MST34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="27242" checksum="8EF64B9196215D53" modified="2021-04-07" version="1" fragment="single">TTALLTHAEVGVWAFALGEGAYMAGASILLTLGHDKALLATLAPGTVAGVLFLASARPADTSVVTWVLLAMTPVAAVVVAAVRTRHQGPRPRLRPAELSAALPAAGFGLVAASLLTLPIIAGAHGRGGPNPGAVLAAVPISLSMGVGEWRLLWFRRRGQALLRNTVEPRRFAFWARAALVLATGEYAVAAAALLAGAAAIAQGAGLLRVTLGVTLELAGYLLLATAMFLALTLQALGARAVPLAVGAAAQATERIGLMTYVTCPIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY65</accession>
    <name>A0A7K0JY65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Transaldolase</fullName>
            <ecNumber evidence="6 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">tal</name>
        <name evidence="8" type="ORF">GHK86_19520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 7"/>
    <dbReference type="EMBL" id="WJHE01001290">
        <property type="protein sequence ID" value="MST34903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="367" mass="39250" checksum="143FE8682F2BD4C9" modified="2021-04-07" version="1">MTRLHELHEVEGQSPWIDNLTRPSVLGGGLQHLVDQGIRGVTSNPTIFEKAMTGSDAYDEQFADIVSRDSVEHAFWDMAVDDVTGACGVLRPVYDTSGGTDGFVSLEVSPALAADTAGTTTAARDLHQRIALPNLMVKIPATEEGIPAIRTMIGEGRNINVTLIFSLPRYEAVIEAYLSGLETFAAAGGDLSQVHSVASFFVSRVDTEVDRRLDKAGGSTSGLQGKAAVSQARLAYELYQRHFSGPRWEALAAEGAVVQRPLWASTSTKNPAYPDLLYVDSLIGPDTVNTMPDATVDAFLDHGTVSRTVDDGVEEARDHLGRLADAGIDMADVARVLEEEGVASFAKSFDQLIQSLSDKANALKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY99</accession>
    <name>A0A7K0JY99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001306">
        <property type="protein sequence ID" value="MST34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="26008" checksum="3AD98AB965CB08AF" modified="2021-04-07" version="1">MRSSTVAADVMIRRLFASWLLPDAWPERGHYSLILGPTVSSSAGERALSILFADGVPIVRSRSARRVLRALATHLASYGAGPAPAGLLRLKAVAVVGDRGGVLLPTGVFGHFDLCRLERELTRMRLRLVDQPWVQVDPATAELVVDAAPLPADAGAPLDEPEERVPSGRFPFIGWFVARHGAAAGAPTPVEAVAHGVTLLRGFGPEGAQWATESVALLAASCRLLPFNASSMDEALSVLEASLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC4</accession>
    <name>A0A7K0JYC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001330">
        <property type="protein sequence ID" value="MST34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="19501" checksum="326C2E45D5992363" modified="2021-04-07" version="1">MADVCLGPRLSGGLAAGLETVPMMRYGLVVVASPGHRLAGAAAIPWHQLTGEDWLVDASGTDPSSEVGMLLARLHVPEARVRVFGSLTAAWAAAQEGEGVAPAIGHLVARDLERGLLTRLDVVSTPVQLLWYAAALPERRRAPGVTPLLRFLATPEAMQAMYRSDGSVPASRFRPPVYVTLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG4</accession>
    <name>A0A7K0JYG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001352">
        <property type="protein sequence ID" value="MST35001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029836405" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6527" checksum="1D37DE34F0F9B8BA" modified="2021-04-07" version="1" fragment="single">MTKRKKRLVQRGLAALAAAGTVMGASAPPMAAASAAVWQSSARFGQTKRGGFILDNNEWHGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYQ1</accession>
    <name>A0A7K0JYQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001416">
        <property type="protein sequence ID" value="MST35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029819242" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="54" mass="5119" checksum="54E452FEF88867B2" modified="2021-04-07" version="1" fragment="single">MLKRPLIVLFVAMATTFGASALAAGTASAAPAPAASPAIALAGTSCYPGSASKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYY2</accession>
    <name>A0A7K0JYY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ChbG/HpnK family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_20470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001423">
        <property type="protein sequence ID" value="MST35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="13068" checksum="2CDCF8B186BE4CD8" modified="2021-04-07" version="1" fragment="single">MSDLAAALGRDRDARLLIVTCDELGVTHAHNAGVYASLRDGMATSAGLVVPGPWAREAAARYRGEDVGVHLTLNAEYDLLRWGPITHCPSLLDGDGGFPRTLEDLWEHGDTEEVRRECRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ43</accession>
    <name>A0A7K0JZ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001516">
        <property type="protein sequence ID" value="MST35207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="117" mass="12690" checksum="4157B38B7C1B20A7" modified="2021-04-07" version="1" fragment="single">MARRIEIELTSSRPDGSWTWRAAGALQPRGVLDGTLLHEGAKPGDVVKADAEFEIDGISIIAILPPREKHRSEPQRIELLAPTREAPGVTTQLAGRGDRRGPGRSDRRGPRPEGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ63</accession>
    <name>A0A7K0JZ63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001533">
        <property type="protein sequence ID" value="MST35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="29"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="381" mass="41404" checksum="64DA65C669BCF713" modified="2021-04-07" version="1" fragment="single">MFDAAPRGRKNATSTVGTGRTDSPYLIMLKLDGIKKTYGQNAALAGIDVDIDEGEFFSIVGPSGCGKSTLLRIVAGLDRPDEGIISIDGMDVSSWEPVDRGIGMVFQNYALFPHLTAGANIGFGLKGKLTKQELRRRVVEIAELLELDDAMLQRRPRQLSGGQRQRVALGRALIRRPRVLLMDEPLSGADALLRERMRSELKRFHERAGTTTLYVTHDQREAMSMSDRLMVLDQGRVQQVGRPIDVYRRPETAFAARFVGSPGMSVWPMAIRAAVDGRALVVTVDGTSWPVDLDAVAGGEQVLVGVRPERLGLVPVSEGSVALQCSVRAIEPQGEQALIHALHDGHEIIAAVTAEAAEEVGTQVELWLSPADVHLFALDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZB1</accession>
    <name>A0A7K0JZB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tkt</name>
        <name evidence="11" type="ORF">GHK86_19525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001290">
        <property type="protein sequence ID" value="MST34904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="10">
        <location>
            <begin position="350"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="670" mass="72727" checksum="B3E21FDE2E7846D1" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD0</accession>
    <name>A0A7K0JZD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001558">
        <property type="protein sequence ID" value="MST35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="62"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17519" checksum="3BEDFE7587F65A90" modified="2021-04-07" version="1" fragment="single">RRYTQLPRPYRRAAALARAVTAGRRSTYGRVEALIGWLGAHTRYSTAIPPLPPGADTVDEFLFGNRVGYCEQISTALAVMLRSLGVPAREAVGYVPGPYDPVTGLYTVEADDAHAWVQVWFPRYGWQSFDPTASVPAANPDPGAVALADVGRALGRVPLLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZE6</accession>
    <name>A0A7K0JZE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001649">
        <property type="protein sequence ID" value="MST35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="oligo_HPY" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="12415" checksum="375633D438CA7962" modified="2021-04-07" version="1" fragment="single">GLEATAAGRYPGQLSGGQRQRVALARALAARPAVLVADEITSALDASVQGAILNLVRELQRSNGFSLLFISHNLAVVRYVSDTVAVMHCGQIVEQGPTEAVLADPEHPYTRSLLAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZJ9</accession>
    <name>A0A7K0JZJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CocE/NonD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001359">
        <property type="protein sequence ID" value="MST35009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S15" evidence="1">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="326" mass="35662" checksum="20BE632ADDCC46CB" modified="2021-04-07" version="1" fragment="single">MPDGCRLAARIWLPEDADTRPVPAVMEYVPYRKNDGLALRDAPIHAYFAGHGYASVRVDLRGSGDSEGVMEDEYLPLEQADGVAVLRWLAAQPWCTGRVGIIGKSWGGFNGLQIAAHAPPELRAVISVASTDDRYADDVHYMGGCTLAVTQLPWASTMLALNGTPPDPAVVGGGWRARWLERLERTPPFADAWVRHQRRDGYWAQGSVCEDYGAIACPVYMVGGWDDAYRNAILRFLAGYPGPCKGLIGPWAHVYPETGVPGPAIGFLQEAVRWWDRWLKDEDNGIMEEPKLRAFVPEATPPATALATRSGRWVALEGWPAAPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZQ0</accession>
    <name>A0A7K0JZQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001674">
        <property type="protein sequence ID" value="MST35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="74"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="234" mass="25178" checksum="BC144DC8A9F11A7C" modified="2021-04-07" version="1" fragment="single">MLLSRRPHRRARRRQRLACPTRCARFVDDTSEPLHNSALRERRLPAGHLAAVARRRDGSGSRERQSPVVTPRPRVVVVGAGFGGLAAVRGLASAPVDVTVVDQDNYHGFWPLLYQVASSELAPEDIAAPIRGMMSGRSDVEVRLGTVEGVDLAGRRVCLGGGAELRFDYLIVAGGTVTNDFGIPGVSAHAYTLKTLPDAVRLRNHVLRAFERADALAEGNGTPPLRPVTIVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMF2</accession>
    <name>A0A7K0JMF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000004">
        <property type="protein sequence ID" value="MST31136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="20146" checksum="6EF24A14A8DBF369" modified="2021-04-07" version="1">MGRWQPDSRGRLQEAALSLYAERGFDQTTAAEIAARAGVTERTFFRHFADKREVLFGGSALLQERLVAAVAEAPEGYGPLDAVAAGLGAAATLLGQFRRDLSRQRHAVIAANPELRERERAKLADYAAAVAATLRERGVPEPQATLAAEAGMTVLPVALGRWAAGPTDRDLSTVVRDVLAELRALVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMK6</accession>
    <name>A0A7K0JMK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_00220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000009">
        <property type="protein sequence ID" value="MST31155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="34782" checksum="1CFF208433C2899B" modified="2021-04-07" version="1" fragment="single">MVDPRAWAVEPGYHDTAGRWREAPDATVQAVLGAMGALEPGRPHPDEDPSLLATVRLDHPLPTLPSGVVHLEDGGELRLADGVLPPDVPLGYHRLAPDDGPERRLIVSPGRCPDAHGSRWGWAAQLYATRSRASWGMGDLADLRTLTEWGRRFGAELTLLNPLHAGPPGPHPQPSPYFPSSRCFANPLYLRIEDIPGADRLDGLDRLAAAGRALNAERRIDRDRVWALKSEALERLFAETSGSPEVAAGLDAYLAERGEALVGFATFNALAERHGLPWQAWPAELRHPDAPAVRAFAAGDEGRRRVRYHAWLQWQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMM3</accession>
    <name>A0A7K0JMM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpsE</name>
        <name evidence="11" type="ORF">GHK86_00505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="18937" checksum="C7AAC33064C31DB0" modified="2021-04-07" version="1">MPPESQYEDRTIKVNRVAKVVKGGRRFSFAALMVIGDGQGTVGLGYGKAKEAGLAVQKGIEEAKKNLFKVPLAGSTITHPVLGEAGAGRVLLKPAAPGTGVIAGGAARAILEMAGIHDILAKSLGSSNSINVAQATVAGLRALKRPDDIARLRGLSAEEIIPTGVLRAYNETQRGPHVPDEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMQ9</accession>
    <name>A0A7K0JMQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsH</name>
        <name evidence="7" type="ORF">GHK86_00520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="134" mass="14877" checksum="ECB532CADC07DCC5" modified="2021-04-07" version="1">MTMTDPIADMLTRIRNANVAMHDEVRMPSSKLKEALAAVLVKEGYITSFEVTTDGNRPGRVLEVRMKYAPDRTRTISGIRRISKPGLRVYTAADKLPRVLGGLGVAVLSTSQGLMTDREARKRRVGGEVLCYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMT3</accession>
    <name>A0A7K0JMT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_00810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000028">
        <property type="protein sequence ID" value="MST31272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="290"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="496" mass="54031" checksum="3EBCC0A8751D338E" modified="2021-04-07" version="1">MATAQLVVDPAFRVGTVDRRLGGSFVEHLGRCVYGGIWDPDDPAADSNGFRSDVLGLVREVQVPVVRYPGGNFVSGYRFEDGIGPPESRPSRPDLAWHSVEPNRFGTDEALGWCAAAGTEAMLAVNLGTRGAGAAADLVEYTNHPGGTYWSDRRAANGHPEPYGVKLWCLGNEMDGPWQIGHRPAADYARDALQAARAMRAIDGTIELVACGSSNSAMPSFPAWEATVLETCYDDVDYISLHSYYGRPSSRGELLAAALDMDRFIETVVATCDHVGARRRSTKRIGLSFDEWNVWHRDAEPDHEPWRQAPPMLENRYDHDDAVVVGTLVNSLIRHADRVKVACLAQLVNVIAPIVAEPGRPAWRQSIFWPYRELIRAARSDSLLVALTTPEHDVAGVGSVPVLDAAATVSEDGDELRLLIANRSPDHSVPTTLDLRAWPGYALVSHEQLADSTSRPAGAPGWPPPVAVPLPAERAGRVDVSIPRLSWNTLVARRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMY6</accession>
    <name>A0A7K0JMY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3090 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="18104" checksum="A792545CEDF9B82F" modified="2021-04-07" version="1">MSESFELADADRLTVGTVGPPGHRVFYLQAGEAGRTITLKVEKQQVAVLSQAIAELLADLRAPEAIAAAGELLEPVDPLWAVGGMQIAYDQDDDRLILVAQELLAEEDADEDDAAVGRLRFTREQAAALVARGEELVEAGRPPCPWCGYPLDPAGHSCPRTNGHRPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN04</accession>
    <name>A0A7K0JN04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000043">
        <property type="protein sequence ID" value="MST31352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="13028" checksum="F654528BE5F9F487" modified="2021-04-07" version="1">MTAAEGREVVTASPRLAGVARPWPAREDLYARGEAGEVLLRSLLRAQLGVTLSVLLPAVVAVGLYPLLAAVFPGVSRATLGPVPLALVVLGGGLYPPLVALGFWYVRRAERVEARFAELVADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNA5</accession>
    <name>A0A7K0JNA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000061">
        <property type="protein sequence ID" value="MST31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="33740" checksum="C4D88B840EFDE9D1" modified="2021-04-07" version="1">MTETLARRALPGCTGGPDVGTPTRPRRRHRRWRDRSPWVRALTYIVLIVLAVVYIYPFLLEIGTAFKTQPDATAHSVNPVPVNWVVSAFVQLRDAGFPRWFENSAILAVSVTLGRLLFDSMAGYALARIPFRGRGLVFAGFVAVLAVPSVVLLIPKFLVFRELGIYNTYAGLIIPLITDATGVFIMKQFFEAIPESVEEAARIDGAGVFRIYWSIVLPMARPALMTLTILSFQGSWNDFSGVLIAQQSPNLDTLTTGVGRLVSGQLGAGNQYPLQMAAALLMTVPVAVIFFTFQKYIVRTGEGATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG4</accession>
    <name>A0A7K0JNG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000087">
        <property type="protein sequence ID" value="MST31512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="32165" checksum="724C1BB9CA3C784A" modified="2021-04-07" version="1">MAPPTQVGPPGNPVDTPVVAHPVGWTEQELGLLSYWIPPVPGQCSLGPGPGFPGGYKAMTLGSGCSGLGTSLSPGTPIVIRQAARRPQGRRIVLNTLAAWESHHGADIVVYDLPRFGVRFELWGRVGAEVGRTIGPSGLDAVLTTPQPVAVPGGWKTVSWGGFSASVPRGWAVTTVRRRPSNVTPRELAEASVTDRRIMEHQCDLFPRAGVYRGDPTWSCQGLSYAEVAGGLWLGKDVNPGPRATPFSTSSGATIVARWSPYAGDASLMGFTVHAGGETIQGTLLIGSDPVLAEQILSSIRATGSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNN1</accession>
    <name>A0A7K0JNN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPD_transp_1_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_01770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="BPD_transp_1_N" evidence="3">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="11893" checksum="09DB270186C88868" modified="2021-04-07" version="1" fragment="single">MLVEDAVEVAPAAPGASVSWGERHPIWVLFLRRGGIGVVTLFVVSLVVFLATEVLPGNAAYAVLGHSATPARIKAIEDQLHLNQGILDQYWHWISGVLSGNPGHSFANGQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU4</accession>
    <name>A0A7K0JNU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="199"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="686" mass="75037" checksum="5A59460086A0A010" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV6</accession>
    <name>A0A7K0JNV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="43"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="297" mass="32736" checksum="735875D1A6A89A18" modified="2021-04-07" version="1">MSDVTTPPPAPQWPDGIRAAAALTFDLDAESPVLTADRANGRRLGVMSHQAYGPLTGVPRLLRLLERHRLRATFFVPGFTAERYPGVCSRIAEAGHEIAHHSYLHEATAGMDAATEAAMIDRGLEALDSVLGIRPVGYRAPMWEINYHTAGLLIDRGFEYDSTLMDCDVPYVLAEHDGPGARSLVEIPIHWALDDWEQYAFVPDVTGSGLIESPAKVLEMWSLELRAYHAEGGCFVLTNHPFLSGRPSRAAALEQLIEVMESLEGLWLAPLGEISRHVRSLDLTPRAFPPPDLEDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNY3</accession>
    <name>A0A7K0JNY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="25669" checksum="6A466114CF9841CE" modified="2021-04-07" version="1" fragment="single">MGEIVRAALFQTQWTGDKESMIKVHEEAARSAAAQGAKVMCFQELFYGPYFCQVQDPAYYEYAESVPGPTVERFAALATELGMVLVLPVYEEEQPGYLYNTAAVIDADGRYLGKYRKHHLPQVKGFWEKFYFRPGNLGYPVFDTAVGRVGVYICYDRHFPEGWRALGINGAQIVFNPSATSRGLSAYIWKLEQPAAAVANEYFVGAINRVGVEDLGDDDFYGTSYFVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP44</accession>
    <name>A0A7K0JP44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD</name>
        <name evidence="4" type="ORF">GHK86_03095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000123">
        <property type="protein sequence ID" value="MST31715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="13"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="214" mass="22770" checksum="ED4F3F0531E156DC" modified="2021-04-07" version="1" fragment="single">MGAAEVDDRRLVRVLLTGAGGQLGTDLQTVFGAQTHHELLAVDRSRLDIGDRDAVASLVGAWAPDLVVNAAAWTAVDACEADPDRAWRVNALGPRHLAEAAARAGAHLVHVSTDYVFDGTKPEPYVEWDPPAPLSMYGRSKLGGEREVAAGCPGATIVRTSWVCGPHGANILKTILRLAEGDRPLSFVDDQRGCPTFTDDLAGAVYRLGVARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP64</accession>
    <name>A0A7K0JP64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrile hydratase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036648">
        <property type="entry name" value="CN_Hdrase_a/SCN_Hdrase_g_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004232">
        <property type="entry name" value="CN_Hdrtase_a/SCN_Hdrlase_g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02979">
        <property type="entry name" value="NHase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56209">
        <property type="entry name" value="SSF56209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHase_alpha" evidence="2">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="195" mass="21242" checksum="1AC6B9EEE063597E" modified="2021-04-07" version="1">MSTDPSPAQRAESLERHLRDHGVLADGEVDAALARAESADGDAPSPALGARVVARAWTDPVFRARLLDDAVAALADLRPLTVPVAVLEDTPTLHHVIVCTLCSCYPSELLGPPPAWYKSFEYRSRVVREPRAVLAEFGTEVPEDVELHVHDSTAEQRYLVLPLRPTGTDGWDEQRLAGLITRNALIGTAWPRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB5</accession>
    <name>A0A7K0JPB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gcvH</name>
        <name evidence="5" type="ORF">GHK86_03560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15981" checksum="468874ADC090426D" modified="2021-04-07" version="1">MPTVRGCDIREDLYYLVEKHVWARVDRDVVEVGLSDVAQGMAKTIISVALKEPGKTVKKGRSLATVESGKWVGPVPSPVNGEVVEVNTALNTHPRKINEDPYGEGWVARVRCRDWEADSADLVTGAEGVQRYQAFLEAEGIACEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG2</accession>
    <name>A0A7K0JPG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_03795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="425" mass="43132" checksum="66DEDC3237284673" modified="2021-04-07" version="1">MLRLAISAFVVLAAEPTFVLVDTAVVGHLGPGALAGLGVGGTLLSLVAMVGAFLDYGTTARSARWFGGGDRGRAVDEGVTATLLALVLGVVGVALGELLAVPLLHLLTGANATVRTASLHWFRVAVLGTPGILVVLAGNGWMRGVQDTRRPVLIVVGANAASAAASPLLVYAAGMGLTGSAVANVIAQLVGGALFVRAVHAEGRPWRPTAARVRGQLAVGRDLLLREVAFQAAFLTAAGVAARMGTAEVAAHQIGFQLWTFIALLLDSFAIAAQSLVGAALGGGDARAARHTAARVGRYGLAAGTATGIVLAAGWDVLPAAFSSSPQVRHQAHLLWPFLAGMQPFAGVLFALDGVLIGAGDVGFMRTVTLVGALGVFVPVTLAALHWHWGIAGVWAGLTGFVLVRFAAGTLRAMGDRWAVVGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP0</accession>
    <name>A0A7K0JPP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IstB_IS21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000176">
        <property type="protein sequence ID" value="MST31932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="12207" checksum="9FF8A84F5FE7A5DA" modified="2021-04-07" version="1">MAELEGLCRRLRLRYIRQQATEVLLTAKAQRWDPAELLRVLLLAEIEGRDASSTENRRKAARFPAGKTFESWEPSRSSITAATQQALRSLEWVDRHENVVVAGPSDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPP7</accession>
    <name>A0A7K0JPP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein beta subunit/FixA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_04260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000178">
        <property type="protein sequence ID" value="MST31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="174" mass="18159" checksum="486F625FAE58C63A" modified="2021-04-07" version="1" fragment="single">MRILVSIKRVPAVGGKIVLADGGTEVDTRFLGFTMSPHEECAVEEAVRLVAARGGEATVLTLGPPESEEQLRYALSLGVDRAVLLETAGQEVGARATAAAIAEAVGALEADDGPFDLLLFGNEAPDTGDFQVGIRVAEALARPCVTGVKALEVGDGDLVARRDRGRGMEVYRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPQ9</accession>
    <name>A0A7K0JPQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000184">
        <property type="protein sequence ID" value="MST31950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10314" checksum="EB5E9555BCEE16A7" modified="2021-04-07" version="1">MIRVLLPQQLRRLAGITGEVAVEVAAPVTLAAVWDALEAAYPVLGGTFRDRASGKRRAFVRFYACETDLSHEPPETLLPAAVAEGAEPLLVVGAMAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY7</accession>
    <name>A0A7K0JPY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_02700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="209" mass="21823" checksum="02B0E496F5810C58" modified="2021-04-07" version="1">MSATVDLAAELAAFGVATCYEAAGRRGLLDLPLTCLHPGTAVAGPARIAACGQGDNRAVHEVMSHVQPGDVLVLRMPRPEPVALLGELLATQAEQRGAAAVLVDAAVRDVGPLGRVGLPVWTRFVSVRGATKAQRGAVDVPVAVGGCIVSPGDWIVLDADGGWTTPAPDIPELIEKARARVEREAGLLERYRAGELSYDLYGMRAEDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ14</accession>
    <name>A0A7K0JQ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="170" mass="18525" checksum="2C7054DBCF1CC147" modified="2021-04-07" version="1">MTAFARFVLFISSYVPLFGVFALLNSFGNGWPTGFCIGLAALGLVVLPTTLLRGRKLAPQPLKADTAQVRDGDALAYIATYIVPFAATTATTARERGALGLFVLLIAVIYVRSELFYINPLLALVGYRLFEVATPAGASVVLLTHRRFLASGTSLMARRLGDYVYWETKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ69</accession>
    <name>A0A7K0JQ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000122">
        <property type="protein sequence ID" value="MST31714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="48" mass="5095" checksum="3C3CF22185C84EE6" modified="2021-04-07" version="1" fragment="single">MAAGRRETALVVALTTLGLLHVAVVSVRYHVGSFDDDAAYLYMAEGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQA3</accession>
    <name>A0A7K0JQA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000213">
        <property type="protein sequence ID" value="MST32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="134" mass="14182" checksum="0B1356B6496E6E82" modified="2021-04-07" version="1" fragment="single">MHPLERLRYAARIEGADPALLAREVAASLAEIAEEDVAGLVPACRRLVDRHPADGPLWWLSARLLASPDPLDEAREAAAALTHDPTAERLAAALPEEVTLVAVGWPDVAGEALRRRGDVEVLLVDSGGEADGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB3</accession>
    <name>A0A7K0JQB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000215">
        <property type="protein sequence ID" value="MST32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="424" mass="45315" checksum="233A7C67C28772EF" modified="2021-04-07" version="1">MPWPRLLALLGSGETAPTMVKPHRAIFERLAPDPVPAVLLDTPYGFQENADDISARAVDYFAASVGRRVEVAELRRRETDDPVRREAALARVAAARWVFAGPGSPTYSLRQWAGSDVPALLRDKLDHGGAVVFASAAALTLGRHTVPVYEIYKSGADPAWAEGLDLLAGALAPDVAVIPHYDNAEGGNHDTRFCYLGERRLRLLEEQLPEDGWVLGIDEHTGCVLDLDERTATVVGLGAVTVRRRGQSSTVPAGTVMKIDELIGLSRGKSGPATRCGDVPGPAAGSAPAPRDVSPFHADIRRLETAFDAAVAARDADSAVRAMLELDDTVHAWAADTLDSDAADRARGALRRMTARLGDLAKAGARDPRELVGPFVEALLAERAAARAERRWADADRARDALVGAGIEVRDSPDGTVWELAATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH4</accession>
    <name>A0A7K0JQH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000239">
        <property type="protein sequence ID" value="MST32196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="PTHR23200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="19836" checksum="8DA6DB647AAE4E55" modified="2021-04-07" version="1">MPALLDVLVTGYADERVASTVVLVRDGGQVIVVDPGMVADRRAILDPMERLGVPPASVTDVVLSHHHPDHTLNVALFPPVRVHDHMAIYEGDTWTDRDAEGYQVSPSVRLLATPGHTDQDVTTLVTTTDGLVACTHLWWSQEGPELDPFARDQALLERSRRRVLDLAPVLIVPGHGAPWAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK6</accession>
    <name>A0A7K0JQK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ion_trans_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_05615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000241">
        <property type="protein sequence ID" value="MST32203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="19838" checksum="095634B859C3BC5F" modified="2021-04-07" version="1">MAGALELAALALTVLATGVIRDRWAQVALAAGGVGALGAVSETADQGLVFGIASLVAAAVFAVMFVAVMTRVLRQQAVTIQTLFGAVCAYELLGFLFAGIYGGFGGLASRPFFGGPVNRSTYSYFSYITLTTAGFGDYTAKGDLARRFVAIEAVVGQVFIATTLARLVALFKGPSRDGREPASGTPEGDRGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS3</accession>
    <name>A0A7K0JQS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="46" mass="5124" checksum="82350159C9ED24FE" modified="2021-04-07" version="1">GLVRRPPAGVEPASVRWVLCHMIEEYARHNGHADLLRESIDGQTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQX4</accession>
    <name>A0A7K0JQX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lycopene cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_06395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000276">
        <property type="protein sequence ID" value="MST32350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="15070" checksum="A2AB585BCBC355F3" modified="2021-04-07" version="1">MDHFQYLLLMAGCVVLTLPLEVVLGARVWRRPRRLVATLVGPVVVFSAWDVAAIADHWWHYARRYVTGVDLPGRLPVEEVVFFVVVPVCALLTFEVVSAALAAPAGTPWWRRLRWARTRGKTSPGGRRPAAGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQZ8</accession>
    <name>A0A7K0JQZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_06320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000274">
        <property type="protein sequence ID" value="MST32337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029443283" evidence="4">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg" evidence="5">
        <location>
            <begin position="391"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="472" mass="49616" checksum="AAAF25661B5F0823" modified="2021-04-07" version="1">MVVSTAVMSTPVMTTASARAVPLLGSALPGGPPGRVAPGEPVTPAVPLIAMSPVRAALRRRALVIKGMVAMGRSSRVGWAATGRTVRRRRSCGAGAASRQLVVGRIAERRAGARRPPRSSLRAATRSTKAANLAGSCTRLGWAAMEKAGIDGLDERIIHGLIVEPRVPFRVLADVVGASPQTVARRYRRLQDVAGLRVTGRVVAPLAGWVDWYVRMQCVPGASAGLAGALARRPDTTWVGLASGGAEVVCSLQARSPEQRDELLLAGLPANRRVVSLSAYALLHDYSPPALPRLTQALDEEACARLRHTSPDKPGGRVGSLDAHDERLVDLLAGDGRASSAFLASAIGWHESTIRRRIADLRHGGVLQFDVDIDPGVFGADVHAMLWASIDPAQLDAVGTAMAQHVEVPFVSATTGPTNLMAAIVCRDPSSLYEYLTGRLAPLPGIKTTEVSLLIRTVKRAAPAGGAMAAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR16</accession>
    <name>A0A7K0JR16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000283">
        <property type="protein sequence ID" value="MST32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dhC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="17663" checksum="001DC4971E7D4CBB" modified="2021-04-07" version="1">PLVAAGAVEPTGVIVDAASGVTGAGAEARPTTRFAAVDEDFTAYGLLTHRHTPEIEQATGAQVLFTPHLAPMNRGILATCYARPTGGDDPMAVLAEAYAGSPCVTVASRVPSTKAVLGSNAAHLTARADPRTGWVVALCAIDNLVKGAAGQAIQCANLALGLPETAGLPLTGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR22</accession>
    <name>A0A7K0JR22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000278">
        <property type="protein sequence ID" value="MST32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="492" mass="52233" checksum="91DE7A362CD12043" modified="2021-04-07" version="1" fragment="single">MERVSKGDPRRPDASGDEQRLAELGYRQELPRVLHLWTNWAVGFAFISPIVGLYTIVALGATTAGPPWVWSLPVVVGGQFLVALVYARLAAHWPIAGGIYQWSRRLLGGAFGWWAGWTYLWALVVVLATTAYAGGGFLGQLLGVRTRSAWSHLLLALVVMVAFTAINAVGLDLLKYTVNVGIACELIASVGIGITLVVFFRHQPVGELVRAPHLPGNGPYLPAFLGAVAFTGWAILGFDACGGLSEETHDAGRQVPRATLMSIATVGTVMAISALGLTLATRDPAAVTAGRVADPVSAAVVGAFGPWVERPFLAVVVIGFVACGIAEQATLVRVIYSLSRDGMLPLSRLWRRVSSRNQSPTAAVLLSGALATAAFLYAKVLTVLVDFATGAYYVGFLFPIVAVVVVVVRDRQSLPPTIGRRTQLIAVAALVWLVAELVNIAWPRQPGLPWYEDYAVVVGSGALGVVGLLYFLGRHPHRVAAGRPAADLPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR26</accession>
    <name>A0A7K0JR26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">galT</name>
        <name evidence="16" type="ORF">GHK86_06505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="WJHE01000280">
        <property type="protein sequence ID" value="MST32372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="174"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST32372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="37009" checksum="895B8A992F4CAFC7" modified="2021-04-07" version="1">MTERRYDPTTDEWVTFATHRQNRTYKPAEFCPLCPTLPGAEPTEIPYPSFEVVTFDNLFPSFSPHPPEPEVGTSELYPVAVAAGRCEVVVYSDDHSVTFADLLDDRVRMLVDVWADRTEVLGEEPTVAYVMPFENKGETVGTTLSHPHGQIYGYPEIPPRARRELQAAHSHRDRTGRCVHCDVVGFELRERRRVVAADRGWVAWVPFWARFPYEVHIAPVRHRSSLPELDDDEREGLAVMLATVARTYDRLWGFSLPYVMAFHQLPTDGDADDWRPLSHLHVEFAPPNRAPDRLKYLAGSELAGGAFVTDVAPERAASELRAARSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR74</accession>
    <name>A0A7K0JR74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="69" mass="7496" checksum="B69A1F1D328318E8" modified="2021-04-07" version="1">MRADLDSHATAEVVIATFFGAQAITRSLGDPAGLRRRLDTFWDLTLPSMRAVARSPARPRAGATGSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG6</accession>
    <name>A0A7K0JRG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000314">
        <property type="protein sequence ID" value="MST32503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11733" checksum="4CF6BD6A7527054C" modified="2021-04-07" version="1">MTFHGGIYVGGLVVRANTFAVVPPGHRHRIGIGVIPACNDTNQSHSHDQKMAVYAIDGFGSSTLLADPGGQVWQRALPSNPVVPTHQAVVGGHQLLREPWVGSTHTPNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP6</accession>
    <name>A0A7K0JRP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dodecin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000257">
        <property type="protein sequence ID" value="MST32254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="61" mass="6926" checksum="5EA40A3497666EB6" modified="2021-04-07" version="1">MTEISARSTESFEEAIRTGIARATETLRGVSSAWVKEQQVKVHNDQVTEYRVNLLVTFVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ6</accession>
    <name>A0A7K0JRQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="12474" checksum="8A1BF25B36C788E8" modified="2021-04-07" version="1">MTTTAETPAAPPRPRRGYWIPGLIALTFLVVVSVLFVLVGLQSHVGRTLQGPVVAGDLALDLESGGTTPNVHCPAQEPRRPGLSFDCTADRPGRAPVTIRVTETTATGGFRYRLLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS07</accession>
    <name>A0A7K0JS07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplT</name>
        <name evidence="8" type="ORF">GHK86_08305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000369">
        <property type="protein sequence ID" value="MST32722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="125" mass="14034" checksum="C8B36D90B27AE236" modified="2021-04-07" version="1">MARVKRAVHSKKHRRAVLEQAQGYFGNKSRSYRAANEQVLHSLQYAFRDRRARKGDFRQLWIQRINAAARQHGMSYSRFVAGLHAAEVEVDRKMLADLAVRDAAAFAALVEVARKALPAADSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS18</accession>
    <name>A0A7K0JS18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_08280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000367">
        <property type="protein sequence ID" value="MST32717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21545" checksum="DE69F7BBDE91614B" modified="2021-04-07" version="1">MAALFKDSWFDHVSSVVSLAVTALPEFVVAIGLIIVFSTVVLHWLPAVSLLPPGTYAWSQPTLLVLPTATLVIVIVPYILRMMRAAMIEALESDYVEMARLEGLRPARVTFIHALPNAIAPTIQVIGLNFLYLAGGIVIVEDVFNFPGIGQGLVNAVSDRDIPTIQLIVVILAAFYVFVNIVTDVIALLASPRRRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS37</accession>
    <name>A0A7K0JS37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC2_membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_08380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000373">
        <property type="protein sequence ID" value="MST32737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20447" checksum="8CCEB4DBFE33F0C5" modified="2021-04-07" version="1">MRLGWAHRPQAERRRARPAVELLPRFAWYHLLLVVRSPIGTFVSLVIPLMLLVALDLVTPEMTLRSLGGIAVAQFLTPSMAGFAVLNVGFVDVVIGVTLARDEGVLRRFRTSPAPLWAYFAGRFLTAAAVTAVAVAAVCGVGLLFMGVRLPGDEVANLAGWAAAGLVVCFALGRLRCSCAPLPARCRRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS75</accession>
    <name>A0A7K0JS75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000385">
        <property type="protein sequence ID" value="MST32773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="17477" checksum="42DCDCF346B72072" modified="2021-04-07" version="1" fragment="single">MSDLLEQTADLVALPSVSRDEAVLADRVERQLAATPWLEVTRVGDNVVARTRGDGRRVVLAGHLDTVPPNGNARPRLEGDTLWGLGSADMKGGLAVMLGLAAEAEPPPVELTLAFYVAEEIAREHNGLLQIEAADPQLLAGDVAVLGEPTGAVVEAGCQGSLALAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS88</accession>
    <name>A0A7K0JS88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000387">
        <property type="protein sequence ID" value="MST32783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="28330" checksum="0AA59E4C044AACEF" modified="2021-04-07" version="1">HVTAALAGAGLDVRTAARRAVAGVPGHVQVDLVTAGPGLLGELVDGLQPDVIVNCAGATGGDPALLAAANATGPANLVTALLAGGRPRRLVHLGSAAEYGRSPWGSAVGEDHPAQPVGAYGESKLAGTLLVGLGRAAGLDAVVLRVFNPIGAGSPTTTLCGRLAAALTGPGDGPIVLGRLDAVRDFVDARDVADAVVAAVTARCLPHGIVNVGSGEATPVRALADLLVGHAGGGRPIQEDAPGSARSADVAWQRADISRALADLGWKPQRRLEDGVVHCLEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSG4</accession>
    <name>A0A7K0JSG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000414">
        <property type="protein sequence ID" value="MST32863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9795" checksum="C6B0EF3DE6E45198" modified="2021-04-07" version="1">MKLGELTEEQMARAQQRGWRLVYRVSAAGNHFRLLVRHPDGTRTSSPVQLPPVLLEIVDVLEPDWDGTWEELVQAAEILAAPVNPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI3</accession>
    <name>A0A7K0JSI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000419">
        <property type="protein sequence ID" value="MST32883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="14158" checksum="AD05649E8CD4A350" modified="2021-04-07" version="1" fragment="single">MRAYHDSEWGRPCHGERELFELLTLEGAQAGLSWATILRKRDAYRTAFAGFDPAVVAGFGESELQALLADPGLVRNRLKIQSTVANAAATLRLRESHGSLDAYLWGWVDGRPVVNAPRRPADVPASTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR2</accession>
    <name>A0A7K0JSR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <ecNumber evidence="6">1.17.7.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ispH</name>
        <name evidence="6" type="ORF">GHK86_09690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000448">
        <property type="protein sequence ID" value="MST32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="26829" checksum="C5A109D3E40989DD" modified="2021-04-07" version="1" fragment="single">MDVEKVLLASPRGFCAGVEMAIKALGWMVRVFEPPVYCYHEIVHNQVVVERFRDLGVVFVEDVAEVPPGAPFMLSAHGAPPAVVAAARESGGAVVNAVCPLVKKVHHEVKVRAGKGYSIVYVGHTGHQEAIGTMAVAPDAIHLVESTAEIDAVPEPEGPVAFLAQTTLALDEWKALLDHAQQRWPDLWVPGQSDLCFATTNRQAALKAIAARCDVVLVIGSANSSNTRALVRTALAAGCPRVLRINGPAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU9</accession>
    <name>A0A7K0JSU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="33025" checksum="B1F15297B74936FE" modified="2021-04-07" version="1">MTPDVHPLAGLPEAVRIWEVGARDGLQNEAVSVPTEVKAELVRRLVAAGLRTVEVTSFVSPRWVPQLADAAELFTRLEQRPDVRYPVLVPNLAGLDRARAVGVRDVAVFASATETFARRNLNRGLDESLAQFEPVVAAARTDGLGVRGYVSMCFGDPWEGAVAPEAVVRVVRRLLDMGCDELSLGDTIGVATPGHVVALLDALAAAGVPRSQVGVHFHDTYGQALANTLAALQQGITTVDASAGGLGGCPYARSATGNLATEDLVWQLDGLGIRTGVDLAALVATSSWLAEYLGRPSPSRVVRALAPAPPEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY0</accession>
    <name>A0A7K0JSY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000464">
        <property type="protein sequence ID" value="MST33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="157"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="659" mass="69876" checksum="EF6DE18B507C384E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE7</accession>
    <name>A0A7K0JTE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000525">
        <property type="protein sequence ID" value="MST33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="12324" checksum="099C1534D82261DC" modified="2021-04-07" version="1">MIFITAKFRVKPEHADTWAEISRPFTEACRAEPGCMWFDWSRSLDDPTEYVLVEAFRDSDAGAAHVRSAHFETARRELPPHLAETPRIISQTVDQDGWSELGEFAVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR7</accession>
    <name>A0A7K0JTR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000556">
        <property type="protein sequence ID" value="MST33313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="9"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="34002" checksum="6590C7C69DBC6551" modified="2021-04-07" version="1">MARYQSVLELIGDTPLVDVSQLSPNPRAAILVKLEGQNPGGSVKDRAALAMIEEAEKDGSLRPGQQILESSSGNTGIALAMIARIKGYPVKIVLPENVSVERRQLLQAWGAEIVPSPGSEGSNGAMRRAQALAAEHPDWWFPYQYANPANPKAHFEGTGPEIWRDCPEITHFVAGLGTAGTLMGVGRFLKQQNPDVQVWAVQPPAGEMVDGLKNLDEGFVPPVFTDNDGFELLDRSRIVGPKESILWVRRLAEVGIFAGISSGAIMGAAVKCAEEIDQGVIVAMVCDGGWKYLSTDAWTGDIDAVTERARHVIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU8</accession>
    <name>A0A7K0JTU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="447"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="565" mass="58501" checksum="F4A917E99A875CCA" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ1</accession>
    <name>A0A7K0JTZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein GHK86_11890</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000585">
        <property type="protein sequence ID" value="MST33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="18093" checksum="AEC4678FE219982F" modified="2021-04-07" version="1">MPTFDVVSKLDMQEVRNAVDQAQREVANRFDFKDTGSSLELAEDEVRLQSSTEDRLRALVQVLEEKLVKRQVSLKALDFGKVEEGSRGAVRQTVALRAGLDSDHAKAVNKWIKEHGPKGVGSQTQGDQVRVTGKKRDDLQTVIAGLRGEDFGIPLQFENFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU75</accession>
    <name>A0A7K0JU75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000617">
        <property type="protein sequence ID" value="MST33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5487" checksum="3B649E213EE067EA" modified="2021-04-07" version="1" fragment="single">MSELDDDTELAPAGEGTWAGSINPRWNVGTAPNGGYLIALAARAMLAASDRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC7</accession>
    <name>A0A7K0JUC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000635">
        <property type="protein sequence ID" value="MST33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="212" mass="22280" checksum="408F41717F88851B" modified="2021-04-07" version="1">MSDDTTDHGAATPPSPGAVWDQRYADTDWPSEPDDALVELAAGLPPGRALDLGCGPGRNAIWLARQGWTVTGIDASAVGLRIAGERAREAGVTLELVQADVLTYTPPPASVDLVVVANLHFAPGEREGFFSRAAMGVRPGGHLYVNGHHLDALGLAGPPVPERLYTEELLADLLAPLEVVVSRRERPAHDGGRPLVDAVAWATVPPDGGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUN5</accession>
    <name>A0A7K0JUN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000668">
        <property type="protein sequence ID" value="MST33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="27185" checksum="989DB181F0D42CEE" modified="2021-04-07" version="1">MSAPSADHQISIISDGIELDGYLARPATSAGAGAGRHGLVLCHGFPITPSQRQGNWGGYQELAERLAADTGWIVLTFSFRGTGRSEGNFSLGGWLSDLKAATDALLATPGVDAAWLCGFAAGGALALCAAGEDPRVRGVAAFASQADFAERAGDARRFVTQARRLGIIKDADYPPDLDAWARELLEVRPLSLIGKLPPRPVLLVHGANDEVVPVVDARALADAADGQVELRILVGAGHRLRHDPRAIAILLGWMDRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP1</accession>
    <name>A0A7K0JUP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_cpsA_psr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_13150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000679">
        <property type="protein sequence ID" value="MST33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="72"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="390" mass="39934" checksum="562A6CCD560D41F0" modified="2021-04-07" version="1">MLATMTVVVALALVAAGASYGYLRYQLGRVHRVSIPTLQTSGAGGGSAPSTPAGGPFNVLLVGEDSQGGGQRADTMIVARVDPRTGRAALLSVPYDYFGPIVGASGPNKISDALVNGPADMVATVEQDLGIHIQHYVQINFQGVASMVNALGGVRLHFPYPSRDTMSGLSVPHAGCVRLDGKQSLALVRSRFFSYDKGGVWQYDPSGAFGRIKRQQAFLRAAVRRVQGSLLGNPLRLNRFVSTAVKDVTVDKGLGVGTLLQLARAFRGLGSSSLATFTLPTQIVNNDGQYGDVLYPVAHLDDATIAKWDAAVTASSTTGTATAAGASAHHTAAPSAGGSAASGSAPSGTPASTSTTTTGSKGVVVPGAPQAPLGSIVQDRTAASYDPTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUP4</accession>
    <name>A0A7K0JUP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Succinate dehydrogenase (Quinone) flavoprotein subunit</fullName>
            <ecNumber evidence="7">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sdhA</name>
        <name evidence="7" type="ORF">GHK86_13200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000685">
        <property type="protein sequence ID" value="MST33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="53"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="6">
        <location>
            <begin position="520"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="665" mass="73938" checksum="1F8B8F2E6A91415C" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUT3</accession>
    <name>A0A7K0JUT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">GHK86_13265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000690">
        <property type="protein sequence ID" value="MST33683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="424" mass="42768" checksum="2F0816BC5ED0AAF8" modified="2021-04-07" version="1">MAEPTTNEALYARACAVTPGGVNSPVRAFRSVGGTPYFVARGEGPWVWDVEGRRYLDLVQSYGPAIHGHAHPRIVEAVQAAAGEGSTFGAPTEREVLLAEEITGRVHGCEQVRLVSSGTEACMSAVRVARGATGRSRVVLFEGCYHGHSDGLLAGGGSGVATLGLPASAGVPAAAVADTLVVPYNTVPEIGEDVACVIVEPVAANMGLVPPAPGFLQGLRDACDAAGALLIFDEVITGFRLARGGASAFYGVTPDLWCFGKVIGGGLPLAAFGGRRDVMEQLAPLGPVYQAGTLSGNPLATAAGLASLAMLDDGAYEELGARVARLAAGLASALAAAGLTAQVPVVGTLVGVFFAGEPVTDYAGAKASADTGLFPAFMHGLLQRGVAVAPGAYEILFPGLAHGDAELDLVVDAVGAVAKELAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUZ2</accession>
    <name>A0A7K0JUZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_13795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000724">
        <property type="protein sequence ID" value="MST33785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029904588" evidence="5">
        <location>
            <begin position="32"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="53"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="272" mass="29655" checksum="A6A3BBCEB432EB0F" modified="2021-04-07" version="1">MPAGIWLLALFVVPLVVMLSLSLQSCNPATGACTLTWHWSEFPSQISLYHQQFLTSLWFAAIATAIDLVVSFPIAYWIAFRGGTHKNFFLLMLLVPFFVSFVIRTVVWQFILSDNGVVLGTLKHAHLIPQNAHVLATGGAVVAGLAYNYLPFTALPLYVALERIDHRLLEAAHDLYANRAQGFVKVILPLTGPGIFAAFLLTFVPAFGDYVNQQILGGTGDTMIGTVIQNQFLVNLDYASGAALSVVLLAVALLGIFLYARLLGSRALADYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV11</accession>
    <name>A0A7K0JV11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000731">
        <property type="protein sequence ID" value="MST33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="76" mass="7684" checksum="28E91CF7458BAD1B" modified="2021-04-07" version="1" fragment="single">MSHPDDEVLGMPASTMDPDTAEALLGGVVPPGFEALAAWLTAIRPGPGRADEPLERLAVEALVHAGSPARTGAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG6</accession>
    <name>A0A7K0JVG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpsI</name>
        <name evidence="9" type="ORF">GHK86_14285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000760">
        <property type="protein sequence ID" value="MST33882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST33882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="130" mass="14335" checksum="C99B2C8FBB96F70F" modified="2021-04-07" version="1">MPQPLVQSTGRRKAAVARVRLRPGTGRVTVNGRPIEEYFPSATHRMIITEPLRLAEKDEAYDVDATMDGGGISGQAGALRHGISRALVALEPDVRPPLKKAGFLTRDAREKESKKYGLKKARKAPQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVR9</accession>
    <name>A0A7K0JVR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000823">
        <property type="protein sequence ID" value="MST34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="343" mass="34966" checksum="5CFDCDF4B4731DE4" modified="2021-04-07" version="1">MRPSEAGLSISVTVLLVAAGAWLWGAYSDRHGRRRTILLASGLLVVPTAALAVVPSFGLLLACRALQGLCMPGLLTVGVPYIGEVFAPRLAGRAMGYYVVALVVGGLVGRLGVSLLAAVIGWHAALASLAVLPCAGTAMMWRSLPEGPPATRTARSLGAVASHLRNPRLRRAIAAGSALLFVFIGVFSYVVYRLQAPPFDLGSQASSLVFVLWVVGAIGPSAGRVADRWGWPRAALGSLGLAVAGSALTLVSSLPAVIAGLGLLATGMFSGVTVVQLGVASSTDVDRGTASGLYFSCYYGAGALGAYLPGLAWQAWGWPGVALLAVAVLGAAAAVLASPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW12</accession>
    <name>A0A7K0JW12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000837">
        <property type="protein sequence ID" value="MST34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="528" mass="56524" checksum="79BD8572FDC2F9E2" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA9</accession>
    <name>A0A7K0JWA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000907">
        <property type="protein sequence ID" value="MST34236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="133" mass="15248" checksum="48A06334BA155445" modified="2021-04-07" version="1">MSTEPAGLHRHRAVYVISVAAELAGVHPQTLRIYERKGLLDPARTVGGSRRYSEHDIAVLRRIQDLTNTGLNLEGVKRVMELEAEVRRLQEELVRSKQEAREAVARTHRQYRRDLVPVRNSPERWLPGGRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWB8</accession>
    <name>A0A7K0JWB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000908">
        <property type="protein sequence ID" value="MST34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="229" mass="24222" checksum="9DDCA1E85CCE22D9" modified="2021-04-07" version="1">MNDHRHDGVRTPTATRVYLRPLANPLSLGFLGVFFATMMLTSQQLGWVPASEGHTLDLGILVFTVPVIVIACFYGFLARDTVAATGFGVQAGTWGTVGLVSYLSPPSSHSAALGMILIMGATAVCMPVIGAVNNKVVAGIAMFTTATRWAVTAAYEIDGSSLNEHIAGGWGVLLAVVCLYASLAFELEDQQRRTIIPTLRRNGGELAMRGDLADQVAEAANEAGVRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD3</accession>
    <name>A0A7K0JWD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000920">
        <property type="protein sequence ID" value="MST34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="277" mass="29262" checksum="C81F3AF5BEEA8A3F" modified="2021-04-07" version="1">MRIALAQIDSTLGEVEANLALIADVVCDAERQGADLVVFPELAVHGYALGSIGADVAIAAGDPRLAALASGHADVVVGFHEDGGLRTHNSAAYLAAGAVAHLQRKLCLPTYLAWEERKHASPGQSLRAFDTRHGRAALLICNDAWQAPLPWLAAQDGAEILLVPANSAGGLGPPGFDPGAYWDPLLSGIARMQQCWVVFVNRVGVEAGACFWGGSRVIDPEGRVVAQAPTGEPALTLVDVDVPAARRHRRALPLLAEGRLHLIEREVRRLIEQGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG8</accession>
    <name>A0A7K0JWG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000766">
        <property type="protein sequence ID" value="MST33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="117" mass="12100" checksum="58550FDE2FDA1A4F" modified="2021-04-07" version="1">MAPKPAAVIQPPASAECCPSVLAAPLGADQAVALAQGFSALGDPVRIRLLSMLAAAPAGEICVCEFVGPIGKSQGTVSHHLKILSEAGLVHGERRGRWVWYSLDHARLAQLRAAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWR4</accession>
    <name>A0A7K0JWR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AfsA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000975">
        <property type="protein sequence ID" value="MST34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AfsA" evidence="2">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="16526" checksum="1D6EDDF6D7550DA1" modified="2021-04-07" version="1">MLLWAVPGAGDSIALRCDPALFDHPVDHLPGMAQLEAFRQAATALAAGSDRPVAPLSRLEATFEHAVELDSALWCSATGSSAGEVHLRLHTGTPGSGRPYRRRCSPGEPARCAARRAHPRHRRDPDRQRLPAGGVLGSRRSPGQDRLSPDGESAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWS1</accession>
    <name>A0A7K0JWS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000980">
        <property type="protein sequence ID" value="MST34395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="64" mass="7190" checksum="DBAFA93BD1A91BC2" modified="2021-04-07" version="1" fragment="single">MRLDVGSLQELQEAGYLTTKLGAQPVCVFWHEGRAYGIDDRCPHLGFPLHRGTVESGLVTCHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWX9</accession>
    <name>A0A7K0JWX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001016">
        <property type="protein sequence ID" value="MST34457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="352" mass="37303" checksum="09F6A9B104BE9FB9" modified="2021-04-07" version="1">MFPPSLPIRSVGTVTPPPGRRRALRASRRQRRSLWSVQLHQIRYVVTLAEEGQFVRAASRLHVAQPSISAAVRSLEVELGAALFDRSRQGAVLTAAGEAFLPWARQVLADCDAGVAAVEALAGLERGRVTLGATPSLTTTFLPAVVAAFRRDHPAVDLIVDEAGSGDLVRSLERSLVDVALIILPVAGTWLETRALGEEELVLAVPRHDPLAQRGQLQLADLRDVPLVMFRNGYDLREATLAACRSAGFQPTFAVEGLEMDGVLAMAGAGVGAAVVPASVVPPEGPLRAVPFAGRELVRHIGVALRRDRTTSAAVRALIDRVEAAMAPGQDPGAASPKDGGRFSKKARTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX05</accession>
    <name>A0A7K0JX05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000850">
        <property type="protein sequence ID" value="MST34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="13953" checksum="0C7172533A249EA5" modified="2021-04-07" version="1" fragment="single">MLAYKFLEGGRSPFTGWRWELPRAGSEPTWLKVTGPLGLCDNGVHACAPGHLPLWMSDELWRIELDGEVLRTEVALVASQARLLDRVEAWDPAARDAFARYCAGRAQRLADREAATAPVAAAVHSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX06</accession>
    <name>A0A7K0JX06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enterochelin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_17350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001027">
        <property type="protein sequence ID" value="MST34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="198" mass="21747" checksum="5EF49E9625C05ECC" modified="2021-04-07" version="1">RGIQGKSSGGFGALITPMLRPDLFGGLASHAGDTLYELCYLPDFGPAARHLRAFDGSVERWWDDFRGRVAFTHPADMTLLGLYGVAACFSADDDGTPVLPMDTRTGRPVDDVWARWLAWDPVRMVADHADALRGLRAIWVDAGRADEHFLDLGAEAFVRALGDVGVTDVHFELFDGRHGGIDYRYPLSLAYLAERLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX16</accession>
    <name>A0A7K0JX16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001038">
        <property type="protein sequence ID" value="MST34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="11802" checksum="D3A58F55106EA8C4" modified="2021-04-07" version="1">MRDFRRGAVRLHVLHHAAEGEVSGAWMAEELGRHGYRISPGTLYPLLHDLEGAGLVASEERVERGRVLRCYRATAEGRRVLAEARAALAELAVELLPGAVPVPGEAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXA3</accession>
    <name>A0A7K0JXA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001077">
        <property type="protein sequence ID" value="MST34576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="233" mass="22795" checksum="3233434D539F8B95" modified="2021-04-07" version="1" fragment="single">TYGTAGSYGAGGVYGTAALLGGTGTAGPTGSQVVADAQQYLGVPYLWGGTTTAGFDCSGLVQHVYADLGITLPRTSEQQAQVGQAVPSLAAAQPGDLVFFAGSDGTPTSPGHVGIYLGNGQMIDAPYTGTVVREEPVSDAGPVVAIRRIVGTAPTSMAAATSATLAGVGSYAPAFASAGATYGVPATLLASVARVESGLNPSAVSSAGAQGLMQLMPSTAASLGVDPWNPTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD3</accession>
    <name>A0A7K0JXD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_18030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001100">
        <property type="protein sequence ID" value="MST34613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="140" mass="15591" checksum="BCA62AA03240358A" modified="2021-04-07" version="1">MYARARRAAAAVVGAGPAEDVASEAVVRALVRWGRVQEYAERWVVVVASNLAVDLLRRQRVPVVAAGVMRFEDEVVERVDVEGLVRRLPARQRQVVALRYLAGCSEAEVAETLGVSLETVRTHLKRARRELRSSMTREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXE3</accession>
    <name>A0A7K0JXE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_15980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000898">
        <property type="protein sequence ID" value="MST34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="315" mass="32520" checksum="88C5C46B8CE8CA24" modified="2021-04-07" version="1">MLIERREAAILIVAVALFVYFTVASANFLTVANLQNLSQFVGPVAVIGAGEVMLLVCAEVDLSAGTVFVFMPFVVYYANQDLGLPMLVAIVVAVIVAGLVGALNGIVTTSLNVPSFITTLGMLFALDGIMLVSSNAAQLTMPTSGTLSNIFGNYGWSEIIWSVVLVGIMYVVLNRTRFGMHTVAAGGNLVGASEAGVPVNRVKIWCFVLCSALSGLIGIVDATRITVLDPGNPGTQEMFYAIAAAVIGGTALTGGSGTVLGAFVGALVLGVLFVGLTIVGISANAFVLILGVAILGAMIANVQLAKFAQKRRMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI3</accession>
    <name>A0A7K0JXI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2127 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001132">
        <property type="protein sequence ID" value="MST34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="20407" checksum="C0B9DB16EC64063B" modified="2021-04-07" version="1" fragment="single">MKRRRTHQPAPGAKALPAGAERRGRLRPKLRYDLLGCGLHGHALVGTDAARLRPEDALFAREDPAGFRWYRCLRCDAWLPLAVPETPRADTPPERDAVRLPLRGRPLRDRYVLRAIAVERALHVLVLGALVAAVFLFAAHRQLLHQDYLRISADLQRMSGGPARPPHHGIGADVNRLFRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ0</accession>
    <name>A0A7K0JXJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_18330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001142">
        <property type="protein sequence ID" value="MST34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16620" checksum="C1F35A618DA13365" modified="2021-04-07" version="1" fragment="single">TVSEHPTWLVAALLAAALLAVARLARIPASAVPRFPGWVWIGLLVFAVLSLAAGGKPYVHLAGASIGLGALQLSALFLVVSLELLAAGALVAWTTALGDVGPAVATLGRPLRALRVPVDEWAVAVALCVRSLPLLVGEIRVLAAARRLRPKPPNRSLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXJ3</accession>
    <name>A0A7K0JXJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001141">
        <property type="protein sequence ID" value="MST34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029652998" evidence="1">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="11299" checksum="E0E18352D05DB8A8" modified="2021-04-07" version="1" fragment="single">MSALARWCVRHRLVVVAAWLAAIAASLALYASVGAAYSNNFQPPNTPSTQALHIEERAFPIEGGDSEQVVVQAKGGSVRAPADAARIDALVAAVRRLPRVAAVQSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM8</accession>
    <name>A0A7K0JXM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_18500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001165">
        <property type="protein sequence ID" value="MST34706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="39"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="42605" checksum="ACD715D7AC00E08D" modified="2021-04-07" version="1" fragment="single">MTTRHAGWRDNPLQWAEHEARLGAKRVEEAVGGPARTRVVVLLACVLGLDAADKGATGALAAQLEAAFHIGNVELGLLVAASSLVGALAALPFGVLTDRVARVRVLAAVVLVWSAAEALSAASSSYLMLLLIRIGLGLAVGAAGPMVASLTGDLFPPGERGRVYGFILTGELVGAGVGLVLAGDIATVLTWRGGYGVLAIPGVVLAWLLWKRLPEPARGGQSHLEVGQAEIPSAEEVEAHPERYPQPGPDDAGADDAEHPVLEEVRHRGVEADPAIVVKGDPTGMGLWQAVRWVVRVRTNLALIIASALGYFFLGGVRSFAVIFVRGWYGIGQASASSLVLVIGGGAIAGVIVVARLTDHWVGRRRFDARMLSGAGGYILAALVFLPALLIHSLAPAVLLFVVAAFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN0</accession>
    <name>A0A7K0JXN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000927">
        <property type="protein sequence ID" value="MST34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="35224" checksum="DA1C75B3B5E1A7B1" modified="2021-04-07" version="1" fragment="single">MALVMLIDGNSLTYRAFHALPTDMATASGQVTNAVFGFTSMLVNLLKDHHPDQLVVAFDRPEPTFRHEMISDYKAGRAETPDILRQQMGLVRQLVETLRVPLVEVAGYEADDVLATLATRSAAAGDDVIVVTGDRDAYQLVADPHVKVLYNRRGVSDYALYDEAGIEERTGVRPAVYPQYAALRGDPSDNLPGVPGVGEKTAARLINTYGGLDGIFAHLDELTPKLRASLAAAEERVRTNAKATPLIRDVPVEVDPAAAAVGGWDRDELKRLFDFLEFRTLWDRFVEATTQGESAAASPPPAGAALDLDVTAPAGAAAAASTLERWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY08</accession>
    <name>A0A7K0JY08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001245">
        <property type="protein sequence ID" value="MST34836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="126" mass="11943" checksum="86426C17973E7C0B" modified="2021-04-07" version="1" fragment="single">MEQDEPEHLVAWVGDEAVVIDPDDGVAYAVGAADADTVRSSASSRRAFLKVGGAAALGTAAVMALPSVAAASSGALASGTLVLSKGTPGTTRVTLNAGSYRVTLVGGGGGGGFGNTNGLPGGGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY09</accession>
    <name>A0A7K0JY09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001254">
        <property type="protein sequence ID" value="MST34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="246"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="446" mass="46368" checksum="45BF0393E02E1D8C" modified="2021-04-07" version="1">MTRGRAGSGARAWCWYNWGDHGWATPVAAVLIGPWMLALAGGAVGARGVLVRAGPLVLRADAFPSAMVSLAALLQLFVLPAVGARIDTRAAKRRWLAGACVAGSAVCVGLGATHGGAWLAAGLLFLAGSLAEGVSDLTWQGMLPELAGPEDLDGLSARGTALGYLGAGVVLAVNLLIVDLHASLGLSKAVAVRWCFVVSGLWWLGFGLPSLRWLRPRTRGRALAPDRTWRRLRADWRALAGQRHAARYVLAYLCFGDAMSAVIALASTFLTNTLFHDDTTAATPFLFELILVIQFIAMGGAVLAGFLARRVGAKRVLVASLVLWSGVIIYAYAGLHTQLDAVVAGALIGVGLGATGTLARSVFASMVPVGREASFFSIYEVTSQGTAFLAPLLFTVVVDLTGSFRQAILSLIVLFLAGLVLLVRTDTDAAAAGALARPAGAAEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY85</accession>
    <name>A0A7K0JY85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">GHK86_19620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001305">
        <property type="protein sequence ID" value="MST34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="181" mass="20120" checksum="7706B54B15FFC9FD" modified="2021-04-07" version="1">RRGYRPPLPVPWPPVDYRLRYWGDPVLTEPASEVGDLDGTIAALAEGMVATMHEAGGLGLAAPQVGVGKRLFVYQLDEDGEIRTIVNPTVAETDGEWEFEEGCLSMPGLYFPIVRPRRIHLTGWDLDGREVSVEADELEARCLQHELDHLDGVLLLSLLDDRQRRKALKVLRRRAGVTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY98</accession>
    <name>A0A7K0JY98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001262">
        <property type="protein sequence ID" value="MST34862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="42000" checksum="C80D799FFDEF8E1A" modified="2021-04-07" version="1" fragment="single">MAPSPPFPHLFAPLAIGPVTIRNRIVSSGHDTVMVHDGKVTDQLVAYQEARAAGGAGLIVVQVAGVHATAHYTSHNLMAHDDSCIPGYEALVAAVKPHGTALFGQLFHPGREIMESDDGTAPVALAPSAVPNERFRVMPRALTVAEIEELVASYGAAAGRLARAGLDGVEVVASHGYLPAQFLSAGTNRRDDAYGGDEERRLRFVREVLVAARAAVGPSKVVGMRISLDERDPTGLGADAAAAAVVALAGAGLLDYVSVTTGTSATLGGSDHIVPEMGVANGYLAGAAGGLKAAVAIPVIVAGRLNQPQDAERVLAAGQADACVMTRALIADPAMPNLAAEGRTDDIRACIACNQACIGHFHAGYPISCIQHPETGRERRYGRRVPAAGPKRVLVVGAGPAGMKAAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYB8</accession>
    <name>A0A7K0JYB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001319">
        <property type="protein sequence ID" value="MST34946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="132" mass="13225" checksum="C8FFC2886F014E8B" modified="2021-04-07" version="1" fragment="single">MADLEASIQASSLRIHQLSSAFASASAEAASLDQQLAGQLTALGHLRAAAAASRASLLTAAVNSYTSAAPGSGATLPDTGVGAVVGAEYLALASSSVSDTLDAYRLRERQVATAVALIRRERAAARADAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH0</accession>
    <name>A0A7K0JYH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001075">
        <property type="protein sequence ID" value="MST34574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="99" mass="10403" checksum="5C0A65A2D6B2C10E" modified="2021-04-07" version="1">MSEDRGTATAPHFSPHTGRVKAAAILVIVGSLVGAAGSIIAGVEFAAATRRWLQEQNQPPTEVARVRLRQAFLAGQAATRAAADTWSHDGGRQEATSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN5</accession>
    <name>A0A7K0JYN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001393">
        <property type="protein sequence ID" value="MST35060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="25945" checksum="CEA9A89E642D7F23" modified="2021-04-07" version="1">MAERVALVTGASSGIGRAAVVELRRRGLAVLAVARRADRLERLAAETGAAFHVGSLDTAEGCAAAVDAAHRRLGPVSVLVNNAAIGSASDASILDLRREGWRAIMDLNLDAPFELARLCAPDMVEQRWGRVVMVSSTSATQGEPDSAAYCASKAALLGLARSIAIDLAPHGVTCNAVLPGWVRTEMADRSARREADATGRSVEDVWAARAASYPSGRVVSPEEVAATIGFLASELASGVSGEAVTVAGGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV1</accession>
    <name>A0A7K0JYV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PASTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001464">
        <property type="protein sequence ID" value="MST35141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PASTA" evidence="1">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="1">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="278" mass="28057" checksum="A2D97A3E77476789" modified="2021-04-07" version="1">MPGGRGRRRRPASWPVGIPALHGDTVQTARAALHARHLELAVAGRAYDATVPKGAVISQVPAGGRFRRGATVAVTVSRGPQPVAIPSVQGVTLAQAEKLLRGNGLTIGAVRKQTSLTVPAGSVITSSPAGGTALPGKAVSLVESTGKPSVTVPLLKWPQDSSWQQASAALSAAHLHPVESLVYNNKVSAGLVVYTSPAPNAVVRWGATVTVLVSRGPHLVTLPTDLAGQSVAAATSELQAIGVGVSGVRGNPTAPVTGSVPSLGTAVLYGGSVQLVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW7</accession>
    <name>A0A7K0JYW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001185">
        <property type="protein sequence ID" value="MST34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="44"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="26131" checksum="9D396DDF4ED33D12" modified="2021-04-07" version="1">PSLRIVANVAVGYDNIDVAGAAARGVLVTNTPGVLTEATADLAMGLLLAVARRIPEADAAVRGGRFPPWGLFQELIGLDVAGACLGIVGLGRIGRAVARRAALGFGMRVVYAGGAPDPSDAWAAGAERVGFGELLARADFVSLHAPLTPATRHLVDEAALRAMQPGAVLVNTARGPLVDEAALARALTGGWIAGAGLDVFEREPEVEAALLASRRAVLTPHLGSATARTRLRMCATAVDNVLAVAAGAVPPNLVAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ26</accession>
    <name>A0A7K0JZ26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001501">
        <property type="protein sequence ID" value="MST35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9337" checksum="69C7A24E2683370E" modified="2021-04-07" version="1" fragment="single">MTTAEAADRLGVKPATLYAYVSRGLLRRERTPSGSRFDAADVERLALGARRRARTDAPLSFTSELTSIEGDGHRYRGVDARALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ28</accession>
    <name>A0A7K0JZ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001228">
        <property type="protein sequence ID" value="MST34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="12733" checksum="258C63C9BF2951C3" modified="2021-04-07" version="1" fragment="single">LAESADEVDELVVYFRSAGEDATRLAGAAPPSVSPDRRALLRRVPLGVVGVVVPWNWPYTMAAELVAPALAAGNTVVWVPAPSTSACSLLLAEVVSEADWPPGVLNVVAGDGPEVGDAVVGHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ95</accession>
    <name>A0A7K0JZ95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_21410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001575">
        <property type="protein sequence ID" value="MST35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="178" mass="17798" checksum="DFC4AF01FF9F0093" modified="2021-04-07" version="1" fragment="single">MSTESSLLRSPERAPARTGHAAAPTAGTAAALSPLALATILSGTFLAMVDFFIVNVALPTMARNLHASSGLLELVVAGYATAYAVLLVLGGRLGDGRGRKRLFLSGVAAFTITSLLCGLAPSAGALVAARVLQGAAAAMMVPQVLSTIQATGDLPSRARALGWFGATGGIAAVVGQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA5</accession>
    <name>A0A7K0JZA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001566">
        <property type="protein sequence ID" value="MST35267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="167" mass="17038" checksum="164382159477EC5F" modified="2021-04-07" version="1">MDRLVEAVAADLRRTAAVGGEDTARVADLLIGGLGPSLRLHLLETLGEVARDLEASAPGARVRVRLEGADPVLELVPAPAAGEQPPGPAGAGSGDGFASYLEDELMRMTVRLPEGLKSRVEQSAAGAGASINSWIVAAVARSLEGQAGAGPAPGKRMPRRISGFVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZD1</accession>
    <name>A0A7K0JZD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_21290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001553">
        <property type="protein sequence ID" value="MST35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="24893" checksum="A863248989012C17" modified="2021-04-07" version="1" fragment="single">MRARRDAGAKLLVTYMTGGLTTDWVDYVQVMVEAGADAVEIGLPFSDPMMDGPTIQEASVRALARGATPPAILAALAEREQPVPLVAMTYYNLVFRAGVERFAAGLADAGVTGAIVPDIPLEESGPWERAAAAAGVATVLLAAPVSPDDRLAELCRRSRGFVYGVNLMGVTGERATLAGSAGVLAKRLKQRTDLPVVMGFGISTPAQAAEAAAEADGVVVASALMRAVLDGASVASVGERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG5</accession>
    <name>A0A7K0JZG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetolactate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001650">
        <property type="protein sequence ID" value="MST35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="15232" checksum="6CEAF5A28DCABD41" modified="2021-04-07" version="1" fragment="single">FANPGTSEMHFVAALDAVAGLRPVLGLAEGAVTGAADGYGRIAGRPAAALLHLGPGLANGVSNLHNARRAHTPVVAVVGDHATFHKRLDAPLESDIDALAGTVSCWVRRSWRPEDVGPDAAAAVAAARRAPGGVATLVLPADASWSPGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI9</accession>
    <name>A0A7K0JZI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="3">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiB</name>
        <name evidence="3" type="ORF">GHK86_21870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001671">
        <property type="protein sequence ID" value="MST35366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16590" checksum="72D7BD1E062B9D2F" modified="2021-04-07" version="1">MRIAVASDHAGFPLKQAVVEHLRASGHEVLDLGTDSETPVDYPYYCAACARAVVRGEADFGVVVGGSGQGEQLAANKVHGARAALCHDEYTARFARRHNDANLLSLGARILAPELALAILDVFLATGFEGGRHIPRIEQIAAIEAEEAAHPSNAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZK9</accession>
    <name>A0A7K0JZK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001365">
        <property type="protein sequence ID" value="MST35019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="11809" checksum="BD03981B06818BAB" modified="2021-04-07" version="1">APDGDRARLAGIMEFAGADAPPGRGRIPSMVRAVRPLLAGLDLDDRADEWVGPRPLSADGVPLVGATRTPGVYVAGGHGMWGVTLGPLTGQLLAERIVTGRTPELLRPLDPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZM7</accession>
    <name>A0A7K0JZM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-guanine transglycosylase</fullName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001638">
        <property type="protein sequence ID" value="MST35332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TGT" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="16268" checksum="6F47F0C24FA13695" modified="2021-04-07" version="1">PRHEMLPAVAASVAALPADRPRYLMGVGDPVSLVEAVALGVDMFDCVLPTRLARHGTALTSTGRLAVRAARYARDDGPLDPACGCPVCARWSRGYLRHLLVVGEPTAGRLLTRHNLAWLIGLVRSIRKAIVAGTLDELRAAIGATWEPGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZT4</accession>
    <name>A0A7K0JZT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DivIVA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001678">
        <property type="protein sequence ID" value="MST35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="370" mass="39486" checksum="0956B55B84789A00" modified="2021-04-07" version="1" fragment="single">MATTARPSFTTARKGFDPSEVGAYLDRVEAELRALRAQGEEERQRNSALETELAAVKEQLEAKPAAPAAGELDETAIAAAVGEEMASVIRTARAVAEDLRAKATADSEQILGAARTDADDIMRRARSEAEEAVTGARAEATQSLESARAEAARTIEQAKEEADRLLQVARTEAERTRDEATQLYAARIEEANRKMGEATADAERHAAEIRAKATVEVEAILAKASAEAASMRSEADRERRVSLEQAEAARERILSDLARRRRVATVQIEQLRAGRERLLVSYSIVRRTLEEVSEEFRRADAEARAAAEEVGRRLAAEIGPDARLDDLPGDFATDDAAAAMGTAGAGTPTGTGAPDGTPAPGGEDGGTPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZZ7</accession>
    <name>A0A7K0JZZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001463">
        <property type="protein sequence ID" value="MST35139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="288" mass="30654" checksum="DCA15E9E5C9B5C2C" modified="2021-04-07" version="1" fragment="single">GSPGPWRPTPGAQPPGLQPPDLRQWQRLHPASAIVRIGPGLAALLVLYLLPAAAGGSRSDDWIHLAVVALVLLGGLVTWLVTRWRLADGVLQIETGLIRRQSLRFPLTQIQAIDVVRPGMARIFGLAELRVRVAGGRSRGRLSYLTLAHAEALRAQLLAAAHARQAGQEAAAAARPPVETPLYSIDPRRLLVSLLISGPSVLLLTCVVALAILATVAPRVAQGVAAGSIAYLFGFATAIWRRFNGEYRLTVADTADGLHVRSGLVETATTPLRVHRRASGSDPVSQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMN1</accession>
    <name>A0A7K0JMN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplP</name>
        <name evidence="10" type="ORF">GHK86_00555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000020">
        <property type="protein sequence ID" value="MST31222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="15883" checksum="D828822FED3618E3" modified="2021-04-07" version="1">MLMPRKVKHRKVQRGRLTGQAKGGTTVSFGEYGIQALEPGWITARQIEAARIAMTRHVRRGGKVWIRVFPDKPITQKPAETRMGSGKGNPEFWVAVVKPGRILFELGGVDEALGRSAMERAIQKLPIKARFVTRSVQEEVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU1</accession>
    <name>A0A7K0JMU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ORF">GHK86_00860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000029">
        <property type="protein sequence ID" value="MST31282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="274" mass="28948" checksum="54FF7ED4907C81E5" modified="2021-04-07" version="1" fragment="single">MPAPIGPPDGRKVPRYAGPDTFARLPTLDAVGRAAVALVGVPFDAGVSYRPGARFGPQAVRAGSKLLRPYHPALQVQPWLTQQIADAGDIAANPFSIDEAIEAIEQAATDLLGRADRLVAIGGDHTIALPLLRATARQHGPLALVHFDAHLDTWDTYFDAPYTHGTPFRRAVEEGVLDLDCSAHVGIRGPLYAPDDLVEDHDLGFATITTADVAERGVSDAIGRIKARVGDHPVYVSIDIDVLDPAHAPGTGTPEPGGLTSRELLAIIRGLVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU5</accession>
    <name>A0A7K0JMU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="211" mass="22350" checksum="D3D89E7B079C99C9" modified="2021-04-07" version="1">MPADTPAQQHYDQGFEQGFASPANQAELARLEAIRLPGPGIGGGWPALAMSNTPDGWAREFVTGLLDVDFANQHRRTLGPWLVAAEAPDLMPGVPPGGQYGGLYATVLEPDVTGQPSPIPTEAQWRADASAGVRWSVSGLQVTPDPQWQSMIDAGWQPPDLRATVEDVSGLLSVTQGATSTVHRFSLGLQVGSAHWNAGYGSVLLAGWKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN07</accession>
    <name>A0A7K0JN07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000026">
        <property type="protein sequence ID" value="MST31257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="446" mass="43428" checksum="264A72F1E3210E52" modified="2021-04-07" version="1">MSCSLINPLSYRSCAGDIAKSVAGDAFDSIAKSFGHAAQSATQWLWAQINVATAVHLGGAGFSTVLGMVAAIAGTVAVGLFVIQIIQSLFRREPAGLGRAIRGLLVAFIAGGVSVAVVNLLLAATDALCTGIVQTAVGTDPAGLGRLVLGSSATAALVGMVSGPGGAAGVLLLALAILVAVVIVYVALVIRKVLIVVTAVFAPLAFAGSLADITVAWTRRWIEFTLALVFSKLILILIFVIGYFMLIKGVGQAGTGVTQEITQVVSGVIVLALAGFAPWLALKVVHFTGDHATQLHAMSATTAGGALAVGRMGQKAVPAMGAVTSKLSAGSGNDTTSGDTAGSSTPPAQHTPPTEPTAGGVPGTGDAPGDPGASGGPSTGGGPSPSPGPGGPHGAAAGTGPLSPPPAGVPASGGPAPGPAAAPAGAAAGGSASRPRLPQRCDPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN23</accession>
    <name>A0A7K0JN23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS256 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000039">
        <property type="protein sequence ID" value="MST31338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="91" mass="9442" checksum="4CC56BB87EBE0584" modified="2021-04-07" version="1" fragment="single">MKDYQTTETAGAIPLPEGVRLAMDDIAGTMREGLLAMAVTAGLGVMSALMEESVTAIAGPKGKHQPGRRAVRHGSEAGSVTLGGRRVPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN57</accession>
    <name>A0A7K0JN57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000057">
        <property type="protein sequence ID" value="MST31396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="257" mass="27765" checksum="AE00CFD283B140B7" modified="2021-04-07" version="1" fragment="single">MRPIPVAVHVGPFVFHTYGLGLAITFMFAAWYLGRRLRDNGYDASWVSSTAIWTVVAALVGARVIHVAANSSSYIADPVQVLEVWKGGLSSFGGILFGVPTGFILAHRRCREVPLRTLADLVAPVLLAGWAVGRLLGPQLMVAGGGHPTHQWFGMYYAGQVGRRLPVPIFQSLMTFAVLFIAWQVEKWVTRRGGPHGLVMAVSVGFWGTNRFIEEHLWLAYPGHVGAIATESAGLAFAVAGFASAATLLVRSRGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN88</accession>
    <name>A0A7K0JN88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4193 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000067">
        <property type="protein sequence ID" value="MST31440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="17262" checksum="4AEF8C9ABC9688A4" modified="2021-04-07" version="1">MPDEDLDDEIDIDPDAEELDEEDLEELDGDELEDDDDVDDDGDEDETEEGEEETGGATKVAARDRGDEDEDEEDDDDEDDEVEASLDVILKERLVVEDDEEDDDEPVETDDRGESPLKVLPKQPGEFVCQSCFLVKHPSQLADPERQLCRDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE1</accession>
    <name>A0A7K0JNE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000002">
        <property type="protein sequence ID" value="MST31114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="12961" checksum="B7365F4976A02E39" modified="2021-04-07" version="1">TAVEAMQAGGARVAVVGDGVNDAPALAAAHVGVAMGRHGSDLALETADVVVVRDELAALPAALRLARHARRVVTVNLAFAALVIAALVSVDLAGHLPLPLGVAGHEGSTVVVGLNGLRLLRRRHWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP67</accession>
    <name>A0A7K0JP67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000122">
        <property type="protein sequence ID" value="MST31713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="354" mass="37073" checksum="2749590927C92BBC" modified="2021-04-07" version="1">MTDDAQHPDGAFASDNYAGAHPEVLAAIADANVGHAGAYGADAWTARLGDVVRRHFGEQAAVYPVFNGTGANVVALQALLPKWGAVVCAEGAHIATDEGGAPERVAAIKLLTVPTADGKLTPELVDRQAWGFGDEHRAQPAVVSLTQSSEVGTVYTLAELRALTGHAHELGLRVHVDGARLANAAASLGCSLRELTTDVGVDAVSLGGTKNGGLFAEAVVVLDPDAAPGIPYLRKMDTQLASKMRFLSAQLLALYEGDLWLRSARQANAMASRLAAGLAAVPGVRLAQPVEANGVFAAVPAAVAAAVRREYHFYDWDRSRAEVRLMCAWDTTEAAVDALLDAFRRAADQQLPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP70</accession>
    <name>A0A7K0JP70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Propane 2-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.227</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol</text>
            <dbReference type="Rhea" id="RHEA:49992"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17824"/>
            <dbReference type="ChEBI" id="CHEBI:32879"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.13.227"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.227" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000130">
        <property type="protein sequence ID" value="MST31770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01058">
        <property type="entry name" value="AAMH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012078">
        <property type="entry name" value="MP_mOase_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003430">
        <property type="entry name" value="Phenol_Hydrox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02332">
        <property type="entry name" value="Phenol_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000040">
        <property type="entry name" value="MMOH_comp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="375" mass="43128" checksum="593506BB32326CE2" modified="2021-04-07" version="1">MATTVQGKTVQDKKEHASAPRPEFTNAEAGALAFPSSTSREYNYYKPSRLRRTVYEDVTVEVQPDPERYLSQGWLYAFADGRAGYPQEWTALRSGNWHAFRDPNEEWERTIYVHNARVVHQISQSIETARLNKAFRRWDPSWVRQVEGHVGAWAHAEHGLGMHVFVPAQRDAPTNMHNNAISVNAMHKLRFAQDLILYNLTLSEEFDGFDGQRHQRVWMEDPSWQGVREAVERITTIRDWAEAVFVVNFVFEPLVGALFRSRFIMQVAAPHGDFTTPTVVGAGEVDYARDLRYSRDIFALLVNDAEHATHNHSVMQGWLEQWTPSSVQAARRLQPLWSQPNQRLVRFEDSFAGALEQFHTQVRELGLESPEEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC0</accession>
    <name>A0A7K0JPC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000056">
        <property type="protein sequence ID" value="MST31394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="15285" checksum="FD28D224BCD646DD" modified="2021-04-07" version="1">MSEGNSSHAPSTGTQRSGWTTFAGIVLVVTGVARVFDSVWAFQYNRALPSDLQGALFGTSLNVYGWLWLFVGAGLMVIGLGLVGIGWLADSEAGRWIGVAAAGIGGITAMSWMAFYPVWTVMYMALAVLVIYALIVHPVKGANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH6</accession>
    <name>A0A7K0JPH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin-like phospholipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="291" mass="29773" checksum="0CFA5C210858B325" modified="2021-04-07" version="1">MSRALVLGGGGPVGVGWESGLLVGLSEAGVELGKADLVVGTSAGSIVGAEAVLGWDLEASLALLDTPWPQGAPAEGPGGIELLLAELTQAASGATSADELRRNLGRIAHAAAPFGEAAYLELFDGIAGQPWPAHYQCTAVDTETGEPRVWDATAEVPLHLAIASSCSVPGIFPPVTIDGRHYMDGGMKTALNADFAAGHDAVVAISCFALELPPGLADPLMDMLNAATEAELQAVRSAGSRLEVVVPGADFLDLSGWGLNLMDPSLTRQAFTVGKRQAAAEAERLATVWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPH7</accession>
    <name>A0A7K0JPH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_01760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000070">
        <property type="protein sequence ID" value="MST31459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="235" mass="24643" checksum="3BA31EA6CD4D06A9" modified="2021-04-07" version="1">MRLDGIENRVALVTGGGRGIGRCIAETLRDQGGLVAALDLEPPDIDGVLGVPVDVADERRVEEAFAIVEDHLGPVELLVLNAAILIAEPFEQTMPASWRRVLDVNLTGAYLCARRAVPAMTDRGSGRIVAVSSSAGRTGGGTAAAAYSASKAGLMTLMRSLAREYSRAGIRANAVAPALIDTTMIQDLEDLRDRIPLGRYGTVQEVADVVAFLCSDHASFITGAVVDVNGGFVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPI4</accession>
    <name>A0A7K0JPI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000141">
        <property type="protein sequence ID" value="MST31811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="63" mass="6960" checksum="EECE83BE210AC62F" modified="2021-04-07" version="1">MRVVVNFDLCESNALCMGEAPEVFEVRDDDYLYVLQEEPPESLRAKVEAAAAVCPKQAISIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ8</accession>
    <name>A0A7K0JPJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000161">
        <property type="protein sequence ID" value="MST31878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="50" mass="5292" checksum="00904264684BFB93" modified="2021-04-07" version="1" fragment="single">MSATWWILIAAVAGAAAGTAAVVRYVIRGSDRLVTDAQRTSFQALRTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPK4</accession>
    <name>A0A7K0JPK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-amylase</fullName>
            <ecNumber evidence="2">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000080">
        <property type="protein sequence ID" value="MST31489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="1469"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1971" mass="191929" checksum="A76C3636B0F546F0" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPL6</accession>
    <name>A0A7K0JPL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000084">
        <property type="protein sequence ID" value="MST31499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029641082" evidence="2">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="314" mass="32459" checksum="F4C445FBC4FC8590" modified="2021-04-07" version="1">MSTALTISSSTMLSPSSGSVTGRSASITSRSLSANSAPLPGVRAVGPPSSAVSTTAGRVLHYVGSYNTGVTSVGRGDDGRRAGQLSDDEFSATVSAVTSAFGDPTRRRIYLHVRERPAGVTASEVALHFDLHANVARHHLDKLAAGGYLTVFVPRTGGGAGRPSKHYRPSADGALLAPPQRGNDLLITLLGRALAMLPPAEAEAMAEQVGEDYGRRLAAGMSSGEGQRSSRVALHAIADALTAHGFEAHAEARGGSLALIKESCPFFDTARQHPVICAVDRGMVRGMLSGLSGATVRDDSGSRARGDEVCVTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM7</accession>
    <name>A0A7K0JPM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_04095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000172">
        <property type="protein sequence ID" value="MST31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="218" mass="25320" checksum="931FC783896C191E" modified="2021-04-07" version="1">MADLDHEALVASQQQTLASPRRAYSPGARVLFGLLDLVYGKPRTLSKFKVLELVARVPYQSWEQVAYIAITHTHRRPDFARRVFDRVTESRGQEDNEQWHLLILEELIAAEGTAEPRWKFAVIPQALAFVYYQLSWLLYVLRPAWSYQLNADFEDHAEHEYAALVAEHPEWEHRPFESSFAADYASVATVADLFRQIGYDERVHKEESVKAMAEPRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPM8</accession>
    <name>A0A7K0JPM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1015 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000156">
        <property type="protein sequence ID" value="MST31861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="488" mass="52974" checksum="042269B23F79A1AF" modified="2021-04-07" version="1">PQGGGVLGHRRPRVVGEEHDLLPRVAQPLHRTGRARDRCSGQPDHAVHVEHPGHGRRVSQTPPAPAFPLLRQQPLAERLPGLYAGVVPRFEPFSGLRFSPNRISSLEDVVCPPYDVISDEERERLLARSPANIVRLELPRAEDGDDPYLAAAKLLDAWRDGGILHRDREPAFYAYRMTYTDEFGTPRSTVGVIGALGLEPPGTGILPHEETTPKARTDRLELLRATRANLSPIWGLSPTTGLTELLDSSLHPRPSEHVTCEDGVCHELWPITDRHQIDDIAHAVGSEPVLIADGHHRYETALAFQAEEQAGSGPRPGDHDLVMTLVVELAEDELAVGAIHRLLDGLPDGFDLAGALAPWFDLQPTGPVDAGIGKRMAEAESLAVVTAGGVWLARPKPETTAAATHDLDSSRLDVALAGLPAHRVAFQHGWDLCDAAVRGGHAQAAVLLRPAKVDQIAAIARGGVRMPPKTTFFWPKPRTGMVVRELID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPS5</accession>
    <name>A0A7K0JPS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_04040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000168">
        <property type="protein sequence ID" value="MST31897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="577" mass="61086" checksum="87E831C8B029E7A7" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ91</accession>
    <name>A0A7K0JQ91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="42"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="496" mass="52103" checksum="5278FF4C539D430E" modified="2021-04-07" version="1">MAVGGRAPVARLQKNVLSVPNGIALAAAAMAPVLAVVLNAPAAAPEAGAALPLSFLVAFVVCLLMGNTVTQFARHMPSAGSFYTFNTAGLGQGAGFFTGWMFWIGYAVLAPGLMDAFGSFAHDYVLSVAGASVPWWIFSLAAMAVVIGLSVRSIKASVSVDLTLLTLEVLIFCVLAVIAIADAGHGNTVRVFAPSSSPRGISGVGFGVVFGILSFIGFDAAATLGEETRNPRRNVPVAVGGALVFVGVFYVFAMYALTAGLHLDQAGAMARFLKDANPFVTLAHQDASWLVQPVDLAALAGIFSCFLAIHNTTVRVMFSMGRDQVLPRSIGRVHRSWHSPHLAIVAQTVFTLVVGLATGAWLGPGATGAYGFTGAIGTVAIVVVYMASSVALMRWFWQRPDRNLVLHIIVPALSVLGLAYPLYSVVKPGQSWPYNLVFWVALAWVAAGVALYLWYRSRSPEKITRLGSFLAEEGDDYGGAVTAARPVATSLGETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQH6</accession>
    <name>A0A7K0JQH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03619 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000151">
        <property type="protein sequence ID" value="MST31834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="307" mass="33281" checksum="C6745577DDEBC00A" modified="2021-04-07" version="1">MVLILTENETMRPSPEVTDLVDMAVTAEDAGFDAVMVSEHVVLGPSADAAGRPANRRDYALPGNQDPATPWPAPLPLLAAVAARTTRLRLVAGALISPLRHPLTTAKELATLDRLSRGRLVVLPTVSWHRDEYDALGVPFARRGALLDEQLEVWAGAWKGSPFRYDGDAYRFGDVWLEPKPWRAAGPPLWFGGSSVHDRLIRRLVRYGSGFNPLGTPTDDELARLHAALRDAGRDPDGIEHVGGTRGRFPAADRPADLDEALATIPAQLARGFGSICIKPSQFIDDLEGFATWCDTVITKVAALGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQP9</accession>
    <name>A0A7K0JQP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000253">
        <property type="protein sequence ID" value="MST32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="172" mass="18035" checksum="5CC85DEA26C15705" modified="2021-04-07" version="1">MASEDHIEAGEGQLGAIGTASISRREMLKKGAIVGGAVVWAVPAVELVGTRVAAAQSHHLEADCKVKVPGVSTFRPTGTNKTTIVITYVHNKDPFNYLTETVYVSSGGVVTTSPSSNPEFTFTLSSDGSTLSTNISGSDTIEIVSVVVNDVNYGQLSGFYSNCNPFLIVAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR2</accession>
    <name>A0A7K0JQR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000261">
        <property type="protein sequence ID" value="MST32272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="82" mass="8757" checksum="DA334DA696FAC880" modified="2021-04-07" version="1">MTRRSPYAGLKRVRAVALVVGIVAFTMVIVTAANGGPISTRDHPHLALSIAFAISFWGLVVTGAGYLLLTVVRAVRGSRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQS8</accession>
    <name>A0A7K0JQS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000261">
        <property type="protein sequence ID" value="MST32273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5168" checksum="2E7E4F707ED4BCC0" modified="2021-04-07" version="1">MSVPLEVSIGCAAIGGSSVLAGAVVSTRVAVLFGGFLPRFVVLAGLAEAGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU1</accession>
    <name>A0A7K0JQU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000267">
        <property type="protein sequence ID" value="MST32310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="250"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="612" mass="66946" checksum="45F04BAC95F49CD3" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQW8</accession>
    <name>A0A7K0JQW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">GHK86_04515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000190">
        <property type="protein sequence ID" value="MST31989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="655" mass="71410" checksum="05F47C89C04A569E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQY3</accession>
    <name>A0A7K0JQY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000272">
        <property type="protein sequence ID" value="MST32331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_PafC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="13015" checksum="3C702D5DE90DA2A8" modified="2021-04-07" version="1" fragment="single">MSRAPAPERLNRLLTIVPWVASNDGPTVQEVCARFNVEEAELLADLDLLFLCGVYPFTPDTLIEVDVADGRVWIRFADYFRRPLRLTPGEGLALVAAGEALLAVPGADPDGALAGALAKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR57</accession>
    <name>A0A7K0JR57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000289">
        <property type="protein sequence ID" value="MST32428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="26356" checksum="0425388E4D0594D6" modified="2021-04-07" version="1">MTPPDPTPQPATDTTPNGPAGAAITLEHVNRTYRTGTTEVRALDDLTLQLPTGIAAAIMGASGSGKSTLLHLLGAMDTPTTGTITVNGTHVETLDARQAPLYRQRIGFVFQRFHLLPALSALDNILMPLLPHHPHRRHAEHKARQLLERVGLPDRAQATPAELSGGEQQRIAIARALIGDPILILADEPTGNLDATTGHNIFSLLLQLHTEQATTLLVATHDPAIAARCDTTIHLSDGHLATPTPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRG2</accession>
    <name>A0A7K0JRG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000231">
        <property type="protein sequence ID" value="MST32174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="279" mass="28661" checksum="2052B1F36A330BE0" modified="2021-04-07" version="1">MVATGRHCATGAGGAARVPAPPAPSYAPRVPSPLVRYEQRDGVAAVTLDRPDKLNAVNDALVRDLSAALDRARDEGAGAVVLRGEGRAFCAGHDFGQPDEEVGPAAQARLQRLSGVTQRVRDLPAPVIAAVHGWALGAGCEFALCCDLVVAQDDAVFGFPEVEVGLAVTGGISHLLPLAVGVVKAKELLLLGRRFTAAEALAMGLVNRVVPDAAAQATAWAGELAAKPRLALAVAKTAVDRGAAGDIDAAYAYETAASLALMHTPEAVAAAADFRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ0</accession>
    <name>A0A7K0JRQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000343">
        <property type="protein sequence ID" value="MST32612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07719">
        <property type="entry name" value="arylsulfatase_AtsA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044094">
        <property type="entry name" value="AtsA-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="66"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="379" mass="40505" checksum="9CC927B21B481B5B" modified="2021-04-07" version="1">MSGEINELTELAYEGSEDQLTMTPVVGTPERAYPRVLAPGAEELVTGEIRVTVLGSGDPFVKKSQASASLLIEVGNEQHDRFFFDLGSGALANFNGLRLPVTATTKVFLSHLHADHVGDIPTLLWSLAKSGRRDPVELWGPAGEYGPLGARAYAQHIEAAHAWDMEAMCGHPGQSGARLLTTEVPFDRPATVYERHGVTISSFPVIHILNGAVGYRLDYAGRSVVFSGDTRPCHPLVEACDGVDLLIHETFPSAGVFAKKAGVPEALAEAVVNGAHTSPAMVGKVFAGAGARMSAMWHLVVDHETIGPVFSEMRTQYDGPVVISQDLTVFNITKEAVVTRRATVDPFAWPVVGPSQTGGPPMSVPHEPPAWWADALMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRQ3</accession>
    <name>A0A7K0JRQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000258">
        <property type="protein sequence ID" value="MST32259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10691" checksum="78E971D32E4F75ED" modified="2021-04-07" version="1">MPTREEVLRRIGDGEGYEDAGRALGIPAGLAYLIATGLPADGSDSLAPEDYQRPGLRLGGTQALLGVPHHNPSERRSIDEFVHGRVRADAQMRAAATTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR6</accession>
    <name>A0A7K0JRR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000339">
        <property type="protein sequence ID" value="MST32603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="35278" checksum="D30DBF58CD60B4D0" modified="2021-04-07" version="1">MTTDIELERRLRQAAQRAEAITAEAVIARANQRRRRHRLVAGGLAAAIALIAGITAAATIPDGATSVSVATDPAASRVPPIINTSTVTIRLAPFRAAPGTVIDATLTAGKSLAQISAADYLIVQAWTGASWKPIEFAFLAVGKVRPTDLAYSPHQWMAGVGLGAGTYRMKIPAALPAGTYRLALSVSTLAAGAHRFHPTTAYTRLEVTGTDTCPPLPQRIVTEVNHLRTDKHLGPPRGSPTITCAQAIRDDKHPTGTLPVIGARLMTLTSVQYPHGRLVWIIATTPDPAARLGPMLPPSSTSTTTPPTTPARYGFSIDIIDANTGTWLQGLEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT0</accession>
    <name>A0A7K0JRT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_06050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000263">
        <property type="protein sequence ID" value="MST32284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="93"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST32284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="334" mass="35093" checksum="42C70033949A2047" modified="2021-04-07" version="1">MGPPRGAVDGRDRRPGRGPARADRLGDRPRRRPRGPRGHPADPGGGLPRPDRRPPPLRRCSAPGGGVPMSTAAPSARVARPLVLTLTQLGYVNKAFWRNPARAFFTFVFPLMFLVIFTALLGNGTVPLGELRVKQSSYYVAAMAAFGVITACFNNLAIGMTFQRESGVLKRANGTPLPGPVFLGAQILHAMLVAVLLVVITAAFGHLAYGAHLPTGASLARFLVMLVVGAASFSALGLAMTPAIPNADAAAAVVNVAVLPLAFLSGIFIAFGNGVPDWILWVARIFPIRHFAVGLQAGFLGTPFAWSDVAIVAGWGLAGAAIAARFFSWEPHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRY5</accession>
    <name>A0A7K0JRY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA topoisomerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_08225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000366">
        <property type="protein sequence ID" value="MST32706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="330" mass="34253" checksum="BF37AD3AA9B2419F" modified="2021-04-07" version="1">NGAGGGDGLGLKRLVSEQLTDIDAREINSIPLGETADGEAIVLRVGRYGPYIQKGDDRASVPEDLAPDELTPERAEELLAQGSSERVVGEDPDSGLPILVKAGRYGPYVQVGEADEVEGKPRTASLLSGMDPRTLTLDEALRVLTLPRTVGVDPGTGEEIVATNGRYGPYLKKGSDSRSLDSEQALFDITLEQALAVFAQPKLRRGQRAAAPLRELGPDPVTGGPILLKEGRFGPYVTDGETNASLRKGDTVEGLTPERAAELLADRRAAGPAKKKAAAKKTTAKKATAKKTTAKKAAGKTAAGTAAKAGAAKKAAGATKAARAAAKKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSJ7</accession>
    <name>A0A7K0JSJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000326">
        <property type="protein sequence ID" value="MST32544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="111" mass="11254" checksum="962E1C80D0FCEB8D" modified="2021-04-07" version="1" fragment="single">MGVDPAASRPDGASDRVGDGRVARIRAALPPGGGSAPRLCEVCRDLTRAAGAGVALRAPEGVLGTLCATDAVSRRIDELQFTLGEGPSLDAFASGRPVSAARLEEAAAARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSL5</accession>
    <name>A0A7K0JSL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000331">
        <property type="protein sequence ID" value="MST32564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="246" mass="25700" checksum="CDD9A08C4E3A1E93" modified="2021-04-07" version="1">MPLHVCDSSASASSPSSSCRSMCPAPPVKGRAPDSSLCGPSRRAIPRCGGPSLPRSAVRSRRTRAPIVPGVSPQPCTPDGRPVTPGAVYLAGPSGFFEAGRRWHEEVVVPAVRAAGLVPRDPWAGPSPLADLPADEDGPARRQWLRQANLLQGRRDLELIDESEAVLASLDGPDVDSGTAVEIGYAFARGRLVVGVRTDLRRCGDNDGASVNLMIETCIADSGGVLHTSLDAAVAFLAARLARGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSP8</accession>
    <name>A0A7K0JSP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-6y C5,15-methyltransferase (Decarboxylating) subunit CbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbiE</name>
        <name evidence="8" type="ORF">GHK86_09605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="414" mass="42064" checksum="50B29AACDB3BF1FD" modified="2021-04-07" version="1">MTGAATTAPGHGRLPIAVVGVHGGHPYGPGAVDALAGADVIVGSPRQLAQTAPLRRPEADTVTLAGPLDDVLSRIEAASRDGRAVSVLASGDPGFFGIVRVLAARMGSNVLRVHPAPSAVSLAFARLGLSWDDAAVVSAHGRPLSDAVDAVRSSSQPSVAILASPENPPQIVAEALIAAGEPAGPETTAAVASRLGEEDEVVTISHLSAVAEKDFDPMSVLVLTGRNNRSGTPTLAWGLAEAEFDHRDGMITKAEVRAVALGKLDLPPSGVLWDVGAGSGSVGIECGRLRPGLHVFAVERDPAQVARIRSNAARHRVNVTVAEGAAPDALVGLPDPDRVFVGGGGTEVLAAVLGRLRPAGVVVATYAIVDRAAVAAAMLGNLVELSVSRGVPAGGLGVRLRAENPVFVCWGPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU6</accession>
    <name>A0A7K0JSU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000456">
        <property type="protein sequence ID" value="MST33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="509" mass="54045" checksum="0CE9CD5AAD2DBDB7" modified="2021-04-07" version="1">MIAGPSAPGVVETHISTVFLVGERAFKLKKGLATAFLDWSTPAKRRQACRDEVALNRRLSPDVYLGVLDVVDERGRLQDALVVMRRMPSERSLEALVRAGEPVEDAVRALARLLADFHGGARRDATSAAAARPDAVARLWSGNLEELRSLHAGPGIGVELDAIEHLAHSYQTGRAGLFARRAAQGRSCDGHGDLQAADVFLLDDGPRVLDCLEFDPVLRAGDVLADVAFLAMDLERLGAAGVAAALLRAYRSLTGEDWPASLADFWVAYRALVRAKVALLRAPWDPGAPGQAEELLGLCRRHLEAATVRLVLVGGTPGTGKTTVASGLADRTGWVHLATDEVRADLPPSAAPAEVRGAGYGVGRYRAELVSATYRLLLERAESCLAAGESVVLDATWTSAGHRAAAAALADRLGAHRVDIRCEIGMEEALRRVRRRAAGGGRSELTPEIVRAIAERQDPWPGALPLDTARPVAEVVEAAVAAATAPPPPGRHEGTFGPSSPVPPRPAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT29</accession>
    <name>A0A7K0JT29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_10115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="56"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="185" mass="19132" checksum="2356D3B1EF19E3B2" modified="2021-04-07" version="1">MSGDVPHIASTTTEARVVAEEARSRPPTRSPSAASTSHPLDAHLQPADRSAGAPWCILLVDDRSERRAIMRMVVGTVPPAGRTSVEVIEASDAAGASAAAERRAVDAAIIEVNLAGGGGVEVIEALRGAHPALTLVICSFRADGETRTRASRAGADAYLVKPVSRGELLAACQALRHASPGDRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT52</accession>
    <name>A0A7K0JT52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flap endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000488">
        <property type="protein sequence ID" value="MST33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="277" mass="29321" checksum="4A9F2485B3028843" modified="2021-04-07" version="1" fragment="single">MKVHLVDGTYELFRHFFGAPSHVNGRGVEVAALRGVLGSVLGLLEEGATHVGVATDHVIESFRNELWPGYKDGSGVDPVLWAQSGPLEDGLGLLGVPVWAMVEVEADDALASLAAVAADDPAVEQVLICTPDKDLGQCVVGDRVVQLDRRRGVVLDEAAVVAKFGVAPGSIPDYLALVGDSADGFPGLRGWGARSASAVLARWGSIDAIPPDPRAWEVDVRGAPTLAATLERERDRARLFKLLATLRVDRDLLAGGVGELRWRGPEPAFADLAADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ5</accession>
    <name>A0A7K0JTJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000538">
        <property type="protein sequence ID" value="MST33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="275" mass="29218" checksum="1DF0C75EA2651E7C" modified="2021-04-07" version="1">MAEIMGLAEAVAAVVRDGDTVAMEGFTHLIPHAAGHELIRQGRRDLTLVRLTPDVLADQLIGSGVVRKLVFGWGGNPGVGSLHRFRDAFQHGWPVPLELDEHSHAGLVNRYVAGASGLPFAVLRGYAGTGLEGRVGHYRPITCPFTGERLAAVAAINPDAAVVHAQRADRDGNVQIWGIVGVQKEAVLASSRSLVTVEEVVDRLDPVPGAIVLPTWAVTAVAVAPGGAHPSYTAGYSERDNDFYVAWDAVSRDRDAFRAWIDTHVLHADGAGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL6</accession>
    <name>A0A7K0JTL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000546">
        <property type="protein sequence ID" value="MST33285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="289" mass="29522" checksum="EE3451CE6372C174" modified="2021-04-07" version="1">MARVAGTGGGRINHRGRSWGYTVVIVVIVVLGVALTYTSRRSYVQHLANTTAANAKVAPKVGGTPWNEAYAVDICGRWQKPIDKPVTKTGISTAGNGVIHIAPKIAAAAGKNATLGEFANSVGMTLSGNQIQLPNGKDYLSGNNCGSQPAEIYVKQYAFAGAPTGTVLKQDPRTVRLQDQAMLTIAFVPRSEKGKIPAPPSKIQKNLEKAAAAATPATTTPSITIPPTSSTTAKGATGTKTSTGTKTSTGTKTSTGTKTSTGTKASTGTKTSTSTKSGSTSASTSPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM6</accession>
    <name>A0A7K0JTM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000549">
        <property type="protein sequence ID" value="MST33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="11"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="361" mass="38435" checksum="DC87DF10DEFF51B2" modified="2021-04-07" version="1" fragment="single">RPAGRRAPGGRGVQRPVLERRPDRHAMPRAVHLDDEAARTLQAAGLGARLEAICEPAPLYEWRNGSGTVLLRLGRPLTAPSGWPASSMFHQPDLEALLEERAGDCGVDLRRGEEVVGLEQDGSGVRVVTPSGALRADLAVGADGAGSAVRRLIGARTHDLDFSHAWLVVDVALREARAFDPLNVQVCDPTRPTTAVSGGPGRRRWEFLCLPDEDPAELASPARAWALLAPWDVHPGNATLERHAVYTYRARWAEPWRRGRVLLAGDAAHEMPPFAGEGLCTGIRDAANLAWKLDLALDAPAAAGLLDTYEQERLPDVRAATEFSLGLGEVICVADPAAAAERDAAMAATVGPDAVAAPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP5</accession>
    <name>A0A7K0JTP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglycosylas domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000555">
        <property type="protein sequence ID" value="MST33307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglycosylas" evidence="2">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="70" mass="7606" checksum="0B8BF76634C4C340" modified="2021-04-07" version="1">MCESGDNYRENTGNGFYGAYQFSQQTWTSLGYPGRPDLEPPAMQDAAARKLQAESGWGQWPACSAALGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTU2</accession>
    <name>A0A7K0JTU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000573">
        <property type="protein sequence ID" value="MST33362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="19913" checksum="93479D3CFF2C3867" modified="2021-04-07" version="1">MNGHRHLAIVLPGQSYGPLGPAIRIPLLAVEQVGAEVVEVRYPERPATEDEPWDAFHDSVLEQVRAAVADARPDEITFVAKSLGTVALAALPPSLLAQVPVRAIWLTPIFGQASVRAGAIAMGRPSLLVAGGGDDLHAPQDHAAVAGALRAESLVIPRADHLLEVPGDVIATADGFRSLAERALGFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ0</accession>
    <name>A0A7K0JTZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000473">
        <property type="protein sequence ID" value="MST33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9196" checksum="5561D7D736D440C3" modified="2021-04-07" version="1" fragment="single">MTRESWVVRALVEIADTLVGDFDVVEMLTGLASRCVEPLGISAAGVMVATPPDDLRLVASSSAAMRVLELAEARFLPGDDPLPSGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTZ8</accession>
    <name>A0A7K0JTZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000582">
        <property type="protein sequence ID" value="MST33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="152" mass="16421" checksum="2D0A0EC15B676D79" modified="2021-04-07" version="1">MRSPSEMIERFRERGLKVTPQRACIFEVLYANEVHPSAEAVYAEASGRMPTISLKTVYQTLNDLAAMGEIQQLDVGTGSSRFDPNVEPHHHLVCTRCGKVRDVHVDTGGLRPPEAELHGFEVGAADVVFRGLCAACAASTGPDPAPARTHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU14</accession>
    <name>A0A7K0JU14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000457">
        <property type="protein sequence ID" value="MST33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="15945" checksum="E8B24F4BD2AB04D9" modified="2021-04-07" version="1">MRQVLGRFASGVVVVSGSGPDGPVGFTCQSFFSLSLEPPLVALAPSRSSATWPHLHRSTLFTANVLRDGQADLARSFSRTGVDKFAGVAWVPGPTGTPHLRGALAWVDCRVEQVHAGGDHHLVVGRVLQLAGEDGRPLVFYRGRFASLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU40</accession>
    <name>A0A7K0JU40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">recO</name>
        <name evidence="11" type="ORF">GHK86_12135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000605">
        <property type="protein sequence ID" value="MST33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="10">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="284" mass="29904" checksum="FD2E37CB47ED8B2F" modified="2021-04-07" version="1">MAGLPSRAPAGGDPRVPGPGPPLRQHRPPRRHPELSGGRVVGLYRDEAVVLRTYKLGESDRIVVLLTAGRGKLRAVAKGVRRTGSRLGGRLEPGTHVQLQLYEGRELDVVTQAEAVDQFRAIRGDLARLRDALALLEAVDQVGREGEADARLFAMLLGGLRTLATRPAPLVVAGFYWKLLALEGTAPMVDACVRCGAGSGLVALDLAEGGAVCRACLPTGGGRRAVSPEALALVARILGGDLAGALATPTGPLAAEVTDLATQALEAHLERRLRVPRLLDRSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU83</accession>
    <name>A0A7K0JU83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">GHK86_12175</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="WJHE01000607">
        <property type="protein sequence ID" value="MST33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="344"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="468" mass="49340" checksum="62332F94B5D07BDE" modified="2021-04-07" version="1">MVLTAQEFDVVIIGGGPAGYAAALHGGLAGLNIAVVEKEKVGGTCLHRGCIPAKEFLETAAVYRTVTGAKEFGIVADPPGIEFAQSQARKQKVVDQLWKGLQGLMKKRKVTTFPGTGRLGADHLVTVDDGTELRGKWVIIASGSVPRTIPGFEVDGRLVLTSDEVLDLEHLPASAVVIGGGAIGCEFASMLSDLGSQVTILEGLPKILPGCDKDVADVVVRSFKKRGIDIRTGVTVTGHRPAADGRTTTVQFGDGEEITVEAVVVSVGRRPLSEELGLQGTAVEVDERGFVKVDDHLRTGEPGVFACGDIVATPQLAHVGFAEGMLAIDQMLGDDVVPVDYTKVPWCIYCHPEVAFAGLSEEAAREAGYDVVTKKDPYGGNGRALIVGEPDGLVKVICEKTADGKAGRILGVHMVGPWVTEQLGQAYLSVNWEATPQEVAPFVQPHPTLSETFGETILALTGRGLHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU92</accession>
    <name>A0A7K0JU92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000620">
        <property type="protein sequence ID" value="MST33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="16911" checksum="3821EEE1E8E2DAB0" modified="2021-04-07" version="1">MDLVRAHTARLCGADRYLVHVVMTATGGAEILGGEPLDPATTARIRCDCSTVTHWVDETGEPLHLGRKQRSWNLAQRRAITVRDRGRCRFPNCQRTHNDIHHVQPWEHGGPTDITNGILLCPHHHTLIHDGWTITGDINHTLVFRRPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE7</accession>
    <name>A0A7K0JUE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_10460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000498">
        <property type="protein sequence ID" value="MST33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="493" mass="49892" checksum="F9242C8DC5CEC055" modified="2021-04-07" version="1" fragment="single">MTLDDALHPPTGAPVGAGAPTNRRWWILAALTVAQLMVVLDATVVNIALPSAQRALHFSTADRQWIVTAYSLAFGSLLLLGGRLADLLGRRRVLMIGMVGFAAASAVGGASTGFPMLAAARAVQGVFGALLAPAALSQLTTTFDDPVERGKAFGIFGAIAGAGGAVGLILGGALTQYLDWRWCMYINDVIGVFALVLALLFLPPAERKPGVPIDWAGVLTVGAGLVAIVYGFSEADTRSWSSPVTIGLLVAGVVLLGAFLAVERRSAHPLLPLGILADRNRGAANLVILVSGVGMFGVFLFLTYYVQLILGFSPLLSGVAFLPMIAVLVAVSAVGTARLLPRFGPRWMVAVGMALAAGGLVIFAQLTPTSTYAGVIVPGLLVIGAGLGLVFGAAMNVATANAGETDAGVASALPNIGQQVGGSIGTALLNTLAASAAVAFLHRHGTSKLLQAAASVRGDDLAFWVAAGVFAGGAVLAAILFAGGPIAAATGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUE9</accession>
    <name>A0A7K0JUE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_12670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000641">
        <property type="protein sequence ID" value="MST33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="120"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="35437" checksum="7593542B610BB8AF" modified="2021-04-07" version="1">MVAVAGRDLDAARPPGVTGRAAANPWLRFAVRRLVRFVVSLWVLVSAAWAIVHAIPGNPVRAALGVTAPQALVDQEQAALGLDQPLLAQYWHFLTHVVTGRLGTSLTYRLPVGQVIGARLPATAEIAGLAFAVVVLVAVPLGMAAGVLTRGDRHPRSELAFSASTGIVAAIPPFLLAIGLVAAFAVALHLLPVAGRSGPASYVLPVVSLAAGPAMLLARVVRVETLRVLHEDYMRTARAKRLPARLVYLRHALPNLLTSTLTIAGLVLSGLVAGTVLVETVFAWPGMGTALVQSILQKDFPLVQGFALVYGSAVLLINLVVDVLIAVVDPRSTLRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUF1</accession>
    <name>A0A7K0JUF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltetrahydrofolate cobalamin methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000636">
        <property type="protein sequence ID" value="MST33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="317" mass="33586" checksum="CD4AE6E38EB07453" modified="2021-04-07" version="1">MATPRTPRPPWPRPRTSSPAAGRRRTPEAAGVQTVLRSASKEVVIGDDQPFCIIGERINPTGRKAFQAQLQAGDLSRLEVDVAQQVAGGAMVLDVNMGAPLADEVGLMAQAVKLVQAMTDLPLCIDSSVIEALESGLSAYEGKALVNSVTAEDDRMAAILPLVRDHGAAIIMLPNDEEEIPVDPRRRLELVDKCVEVAHGSYAIPLEDILIDPLAMPVGADTSLVHKTLETISLIRDKYGLNMTLGASNVSFGMPDRHTLGAAFLPMAMVAGLTSAIMDARSPAIVRGVKAADLFLDHDPWGGAWIAAHRAAQAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUH9</accession>
    <name>A0A7K0JUH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EscV/YscV/HrcV family type III secretion system export apparatus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flhA</name>
        <name evidence="2" type="ORF">GHK86_10610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000504">
        <property type="protein sequence ID" value="MST33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="331" mass="34473" checksum="DD398E9A86ED58A6" modified="2021-04-07" version="1" fragment="single">MPSRRLAHYGVPIAVLCAVVMVVVPLPTVLVSILLAGNITFAIVVLLTSMYVKRVLDFSVFPSLLLVSTMFRLALNVSVTRLVLLHGYAGSVIEAFGHFVVGGSLVVGLVVFAIIIVIQYVVITNGAGRVAEVSARFTLDAMPGKQMAIDADLNAGLINQEEARRRRREIAQEADFYGAMDGASKFVKGDAVAAIFITIINLIGGLAIGMIQRHLSIGNAVNTYSILSIGDGLTSQIPALLTSISTGLIVTRAGTNSDMGTDLLSQLGAQRRAVRIAGGGVAALALVPGLPKVPFLLVGGAVIYLGTRLRAADAAAAEPAATDLPPAPPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL3</accession>
    <name>A0A7K0JUL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000672">
        <property type="protein sequence ID" value="MST33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="153" mass="15678" checksum="982046DAE0DC4A8F" modified="2021-04-07" version="1" fragment="single">MWETLAPIGRGAGGGYHRLAWTDADLELRDWFRTEAANRGLELDEDGNGNLWAWWGTPGPGAVVTGSHLDSVPGGGAFDGPLGVVSAFLAVDALRAAGVEPSRPLAVVDFADEEGGRFGVATLGSRLLTGSIPPARAAALADAAGVTLADAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV20</accession>
    <name>A0A7K0JV20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">potA</name>
        <name evidence="10" type="ORF">GHK86_13785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000724">
        <property type="protein sequence ID" value="MST33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="389" mass="42295" checksum="A8876D10E779ABAF" modified="2021-04-07" version="1">MLDAPPGAPTEQYDVRLERVTKRFADVVAVDDLTLGIRRGEFLSLLGPSGCGKTTTLRMIGGFEDPSAGRIFLGGRDVTALPPYRRDVNTVFQSYAVFPHLDVFDNVAFGLERKRVPKREVAARVQEMLELVDLPQLGKRKPSQLSGGQQQRVALARALVNRPKLLLLDEPMSALDAKLRKQMQVELKRIQVEVGITFLYVTHDQEEAMTMSDRIAVMSNGRIEDLDSPEAVYERPTTEFVAGFLGASNLLSGRVTGRSGDVATVAVEDGTVLRCSTRGLPEGGGRAVRVGVRPEKIHVRVGADEPEPGWNHLRGTLRVATFTGVGNQYLVEGPGGTELTVYAQNLGQADAPRTGDPVLLSWRPEHTFVVRPSNAAPAAGSAAQPQENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV60</accession>
    <name>A0A7K0JV60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000739">
        <property type="protein sequence ID" value="MST33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="16626" checksum="C88F050D033E13E8" modified="2021-04-07" version="1">MAPQVTSWNTVASFATYLEAHAAVDRLAVAGFPVEEVEIVGSGLRTVERVTGRLSVAGAAARGAGSGAWVGLFVGLLVGLFTYGPAWIGLILGGLVIGAVFGAVLGLVAGWEARRHGEFSSLQSVVATRYDVITLDGRASDARAALGGTAGMPPAQWSGSRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV70</accession>
    <name>A0A7K0JV70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000601">
        <property type="protein sequence ID" value="MST33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5961" checksum="B0A20BB3669887A8" modified="2021-04-07" version="1" fragment="single">MPGVDELLDNWILAEMERDPTRATALGLPGYDHRLGDLSAPAWEARPDEDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA6</accession>
    <name>A0A7K0JVA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000737">
        <property type="protein sequence ID" value="MST33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="162" mass="16992" checksum="02D80FC3C085470C" modified="2021-04-07" version="1" fragment="single">MTTVRELADRYHEGWLAAHPFAASQYGVPGHDADVPDESEAGDARRRAEVEAALAEARALEGGELSADDAVTLGCLIGSAEQELAALDLGAVEYTVTSMPFAGPATLMALAARTVLPDARAAEDYVTRLQRAGGWIDQYTERLRAGAATGRLPVAPLTADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE1</accession>
    <name>A0A7K0JVE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000778">
        <property type="protein sequence ID" value="MST33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="459" mass="50578" checksum="F05B98B02C20D5A7" modified="2021-04-07" version="1">MAALGIDDAALQEAAKRHLWMHFTRMSSYAEHEVPIMVRGEGPWVYDSRGKKYLDGLSGLFVVNAGHGRQELAEAAQRQAGTLAYFPLWSYAHPNAIELSERLASLTPGDLNRVFFTTGGGEAVESAWKLARQYFRAIGQPGRYKILSRNIAYHGTTMGALSITGLPDIKAQFEPLVPGSVRVQNTNFYRAPEHGDDVEAFGQWAADDIETRIEMEGPDSVAAVILEPVQNSGGCFPPPPGYFQRVREICDRHGVLLVSDEVICAFGRLGSWFGAERYGYVPDMITCAKGLTSGYSPLGALLVSDRLMEPFLTGTSYFSHGFTFGGHPVSTAVALANLDVFEKEDLIGNVSRRAADFRKVLDGLRDLPIVGDVRGDGYFYGIEMVKDKDTKETFDDDESERLLRGFLSPALFEAGLVCRADDRGDPVIQLAPPLVCEQEHFDLIGDVLRSVLTEAWNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVE9</accession>
    <name>A0A7K0JVE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ku protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_14530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000775">
        <property type="protein sequence ID" value="MST33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="3">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="285" mass="31806" checksum="3B3D170E10D36B10" modified="2021-04-07" version="1">ERGTTDRIRYRRVNEVSGEEVAYDDIVDGYDVGRGDYVLVEPEELEEVAPGRSRTIEITDFVEQAEIDPIHYQRSYFLAPAADAAVRPYGLLLRALRDADRVGIATFVMRNKQYLAAIRPRHDVLALETMWWADEIRNPVDELDRLPAGESFADRELRMATSLIDSMTVAWDPSAYHDTYREKVEALLEAKADGRQVTPETPGDRGGEVVDLMEALERSLAAAGDRRKGGTPSPGAQRQRRGRGGADDLAGLTKSELYERAQRLGVPGRSSMDRDALEDAVRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVF6</accession>
    <name>A0A7K0JVF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_14495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000773">
        <property type="protein sequence ID" value="MST33923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST33923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="242" mass="25882" checksum="3D3B82A199B770FD" modified="2021-04-07" version="1">MAAMFTLAFPLLMLVIFGSVFNGTVAPGVSFAEYFTAGMIASGAFYSGFQNLAIAVPLERDNHSLKRLRGTPMPAAAYFVGKIGAVLVIYVAQVAVLIGLGSLLCGLRPPTSVGPWLTFAWVSVLGLTACSLCGLALSGVIRRSEAAAAIVSPIVVVLQFVSGVYFQYDHLPAWMRLLGSLFPLRWLALGMRSVFLPPGFARYEPGGAGWQHGLTALVLVAWSAVGLAVALRRFRWYVEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH9</accession>
    <name>A0A7K0JVH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="7">2.7.1.49</ecNumber>
            <ecNumber evidence="7">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiD</name>
        <name evidence="7" type="ORF">GHK86_14595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="7"/>
    <dbReference type="EC" id="2.7.4.7" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01000783">
        <property type="protein sequence ID" value="MST33943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="16"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="27693" checksum="06CF7471A5497A12" modified="2021-04-07" version="1">MTSRTPPVVLSIAGSDSGGGAGIQADLRTFAALCVFGTTAVTAVTAQNTTGVRRVDVLPPEAVTAQVMAVLDDLPVAAVKTGMLADAGTVDAVAGMAAAERLPNLVVDPVMVASSGAVLASDDVVAAYRRRLLHLATVVTPNVAEAAVLADVTGAAAADQTVLARILGERTGATVVVTGGHAGGPRCADVVWHAGEIQVLARPRLATGNTHGSGCTFAAAVTAGLATGAGVLEAVQAAGEFVHAALRSGSSWRLGAGPGPLDHFGWSRPEVGTGPAGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL6</accession>
    <name>A0A7K0JVL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000641">
        <property type="protein sequence ID" value="MST33569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="27045" checksum="EACA525445A9EEDA" modified="2021-04-07" version="1" fragment="single">MSAGGRARWAATLRTPIGAVSAVLVAALVVLAVVAPAAFGHGASTDDVAAALQGPSGRHLLGTDALGRDLLDRVLVATRTSLLMALLATLISTVGGLLLGAVPAVVGRRAGGLVGAFITLTVAFPGLLLAMFLSIIFGLGERGALLAIGLSGVPSVARLAQTLGASIADADYVTAARMLGVRRARVITRHILPNIAEPLVISVTLSIGSALLAFAALSFLGLGVQPPAYDWGELLNQGLSQISTDPAASLGPAVAVVVAGSAFNLLGDAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVQ4</accession>
    <name>A0A7K0JVQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_15025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000818">
        <property type="protein sequence ID" value="MST34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="236" mass="25513" checksum="99CC18FDC81E0124" modified="2021-04-07" version="1">MDVTDASFETDVLERSAQAPVVVDLWASWCGPCRVLGPILEKVVAETDGKVVLAKVDVDANPRVATTFQVQSIPAVYAVSDRKVVDRFVGALPEPAVREWVRNLLPGDTEIDRLVAAGDADSLRKAVELEPGNEKAVVALARLLADSAERADRDEALALLARIPETAETRHVAAQARLGGEAELAGDGIEAKLDALLERVKGDDEARQEFLDLLEVLGPDDPRTPSYRKALTARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU9</accession>
    <name>A0A7K0JVU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000839">
        <property type="protein sequence ID" value="MST34077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="26291" checksum="F578944CF4D3F400" modified="2021-04-07" version="1" fragment="single">MPRGPGGRVIDLATVARHGLAGAPDPELGPVEATAWTRLVQEATNQRLTGLLVAMVLDGSLDPTDAQEASLVEAHRNALARDLLVERTVLWAVGCLDASGVDHRVLKGTATAHLDYDDPGLRSFVDADLLVRADQWDRAVAALEEGGARRESREPRRGWDRQFAKCVTLTTPDRYEIDLHRTFVFGPLGFTVRLPDLWAGCEEFALGGRRVRALDREARWLHACFTAAAADVPARLVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW33</accession>
    <name>A0A7K0JW33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000879">
        <property type="protein sequence ID" value="MST34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="77" mass="6867" checksum="AA2985021A3E7603" modified="2021-04-07" version="1" fragment="single">MTYTFQLVGGGGGGGGAFANQSAVGGRGGGGGGGTITGTFVASHAHELTLLVGGRSDAGGEGPAAAGGTGGYEPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW96</accession>
    <name>A0A7K0JW96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hrcA</name>
        <name evidence="7" type="ORF">GHK86_13965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000736">
        <property type="protein sequence ID" value="MST33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="105"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="335" mass="35099" checksum="EAA3D918566E29ED" modified="2021-04-07" version="1">MLDDRKTAILRAVVEEYIQTAQPVGSSHVAREAGLAVSPATVRNEMNQLERDGYLSQPHTSAGRVPTDKGYRFFVDSLTTPGTLDEVRTQQVRAFFARAHGELERMLGDTSRLLSGLTDYAAVVTAPNAEALTLRSVQLVSLSARVVMVVAVLSNGSIEKRTLDLGPDAAVSDVTVGAASAHLASSLNGTVWGSTAAPPTSGDPGVDDLVSRAHDALVAAAPTGSDQVYVGGAARMAAAFDAVGTIRQVLSIMEQQYVLVTLLRDVLDRGLSVAIGTEHGLQPLADCSLVVAPYDVEGDRGTIAILGPTRMHYDQALAAVGVVSERLGRALSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWC2</accession>
    <name>A0A7K0JWC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein FlbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000745">
        <property type="protein sequence ID" value="MST33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="89" mass="9740" checksum="6C84EB185E4A9E5E" modified="2021-04-07" version="1">MILVTRLNGPALALNADLIERAEATPDTVLTLVDGTKFVVEESIDELIERMRMHRAAVLAYASEIERGTGQPPQSGPRLRVIPGSEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWD4</accession>
    <name>A0A7K0JWD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GHK86_16205</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000917">
        <property type="protein sequence ID" value="MST34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="15">
        <location>
            <begin position="163"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="320" mass="35251" checksum="AFC14D5E00F0A950" modified="2021-04-07" version="1">MSAVNLSGKDPDATPGSRHLLRIFLIWLTGSVILELVIGLGLAPHLSPGNMTNTAQSQQWDIEVLLWLAAPVLVLVYTWFGYNLIVFRHRGGPITDGAWWPRDKTWIQVAWVLSTASVVLFCFGFGTYELVGARYGAGGGEGPSAIWAPPVKLASAWKPASNPTELQVQVIGQQWRWTFRYPQFGGMETTRLVIPDHTWIRFDVTSLDVIHSFWAFQLGVKADANPGVDNIAFTKAQQLGNFAIRCDELCGIWHGAMVSTGTVMSQSAFYSWAQHQQTALAATTAQLPKFALTYEPSFEGAGGQLYQGRVYPNPHPNSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP1</accession>
    <name>A0A7K0JWP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000962">
        <property type="protein sequence ID" value="MST34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045713">
        <property type="entry name" value="DUF6069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19545">
        <property type="entry name" value="DUF6069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="17861" checksum="729BC040811ED462" modified="2021-04-07" version="1">MYYRLAELVHLDFAPRHRQPNGSAVVVATIVALAGSLIVDAILVALGEALWPGLKGYVHFRFSDYAKLTVIGVLIACAAWPITTRITSMPRWMFVRMAVAVTLVLYLPDLYLLVLGDPGKAVLVLMAMHLAIALVTYNALVRIAPVRTVRTAADRLAALRVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWV9</accession>
    <name>A0A7K0JWV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001007">
        <property type="protein sequence ID" value="MST34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="21137" checksum="03FF34182D9C3EAB" modified="2021-04-07" version="1" fragment="single">AVALKGRVVFAEAYGHADLDGGRRLRPDDVFRIASHSKSFTAAALVQLAGEGRLHLDDPVADHLGWVRDHRDRRWAAVTVRQLLCHGAGIVRDGLDSEFWQLGRPFPDRDQLRDEVLAADLVLEPNLAMKYSNFGYGLAGLVIEEVTGRSYHDHVRERLLDPLGLVATTPEHRGSTELAKPKPGGRRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY2</accession>
    <name>A0A7K0JWY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crotonase/enoyl-CoA hydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_17240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001016">
        <property type="protein sequence ID" value="MST34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="PTHR43149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="276" mass="28415" checksum="57F8EF9DA2CDA4B1" modified="2021-04-07" version="1">MVSGDRVAVAVRDGVADVRLNRPEKLNALDVPLFRALVATADALAADGSVRTVVLSGEGRGFCAGLDFAAFQAMSGDSAGSDVREELGRRLPGRSTNLAQQAVQGWAELPVPSIAAVHGVALGGGLQLALGADLRLVAPDAQLSVLEVRWGLVPDMTGTWVLPRLVGPDVAKELTWTGRMVGGEEAVRLGLATRVADDPRAAALELAARIAAASPEAVRAAKALLDRSTSGADRAGHYLAESAAMGALIGSPNQVEAVRAFFEKRPPSFGDAAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWZ3</accession>
    <name>A0A7K0JWZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hepar_II_III_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000834">
        <property type="protein sequence ID" value="MST34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="261" mass="27125" checksum="563DF08AA9796691" modified="2021-04-07" version="1" fragment="single">HLTVLAAAWAVTGDARYAAAVDRQLRSWWARNPLLAGVHWTSGIEVGMRLVAWVWIRRLLEGWAGAPALFEGNPAALDQLWWHQHYLESFPSRGSSANNHLIAEAAGQIVAALALPWLDCSPRWAEGAADRLAGALEANTFASGLRREPPQPAPGHRHPDRHQPGVRARPGRGRLAHSSTPTVGAGATGPVPGLAAVSGAGGRPPSVVADGLAASNTLAATATRRCVARTADSGSAPAQPSLASGGGEVGVCRQDASVDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX23</accession>
    <name>A0A7K0JX23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2399 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001030">
        <property type="protein sequence ID" value="MST34486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024465">
        <property type="entry name" value="DUF2399"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09664">
        <property type="entry name" value="DUF2399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2399" evidence="1">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="12684" checksum="6284154139F1720E" modified="2021-04-07" version="1">AMDAGVPAVMACTAGNPVVTVTVLLERLAGDGADLRYRGDFDWPGIAIANRVVTGFGATPWRMSTLDYEAALAGAGRELLELPGLVGAPVEAAWDPGLRAAMAGAGRAVHEELLLGTLLADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX79</accession>
    <name>A0A7K0JX79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001029">
        <property type="protein sequence ID" value="MST34482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="21512" checksum="07569518AD5DA7BD" modified="2021-04-07" version="1">MAAATRRSQADGEATRLADGRAQHERLADLESEARHLARVAVLLSEFRNTVVASVGPRLAAQAAELFGELTDREYDRLLVDPETYELQISDAGRVYGLDRFSGSEVDLANLALRVAISEHVRFQSGGTVGLLVLDEVFGPLDEDRKARMLQALEQLRGRFRQVLVVTHDAGIKEQLPNALEVVKLAGRRATARVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX89</accession>
    <name>A0A7K0JX89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ORF">GHK86_17760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="WJHE01001070">
        <property type="protein sequence ID" value="MST34560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="176"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST34560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="329" mass="34330" checksum="B0B205D70346596B" modified="2021-04-07" version="1">MNVTVLGSGSWGTTMASLAATRNPTLLWARRAETADEVTTRHTNERYLPGFPLSRQLRATVDLDEACAGADVLVVAVPSANFRAVLAEAAPSVRPWVPVVSLTKGLERGSLLRMTQVVEELLPGHPAAALTGPNLAREIMAGQAAASVLATKDPGVAAALQAVLTHRMFRVYRNHDVIGCEVGGALKNVIAIAAGIAEGLGVGDNTRAAVITRGLAELTRLGVAMGAQPQTLAGLAGMGDLIATCMSPLSRNRSVGEQLGRGRNLPDILAEMHMVAEGVGTAGLVLELADRWGVELPICREIDRVVRGDASPLEAYRGLVAPGHEADPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX92</accession>
    <name>A0A7K0JX92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">yidC</name>
        <name evidence="17" type="ORF">GHK86_17815</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001074">
        <property type="protein sequence ID" value="MST34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029592176" description="Membrane protein insertase YidC" evidence="16">
        <location>
            <begin position="25"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="304"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MST34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="512" mass="53675" checksum="A483FA11CF443219" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL6</accession>
    <name>A0A7K0JXL6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fdhD</name>
        <name evidence="4" type="ORF">GHK86_16265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000922">
        <property type="protein sequence ID" value="MST34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="29446" checksum="CEA149861763F157" modified="2021-04-07" version="1">MRAVTDVRAVKVRPGRSLELPDRLTTEEPLEIRAAGPGQESEPVAVTMRTPGHDFELAVGFLVSEGLVTPPEVAAVGYCDAADPDNRFNTVTVSLRRPWQAPTTRTFVASSSCGVCGKTGIDQVELACPVLPAGVPVPAAVVPTLPDSLRAAQRVFDRTGGLHAAGLFDHEGVLHVAREDIGRHNAVDKVIGQRVLEAVGGPGPDRAVLPPAAALLMVSGRVSFEIVQKVAMAGIPVVAAVSAPSSLAVAAAERLGVTVAGFVRGDSYTVYSHPERIRFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN4</accession>
    <name>A0A7K0JXN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5">1.1.1.169</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001165">
        <property type="protein sequence ID" value="MST34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="131"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="301"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="427" mass="43400" checksum="025D752B2E226146" modified="2021-04-07" version="1">MEGGLQLGGERPGRPLVGGVEAEHAGEQHHDPGAGRAADGLLDPLGAEAGLVLGPLQRVVAPAGVPGGHRAAGSGAGRSSSGKGQGFNATLLGGCRPLAAGTTRDPYPAPPHPNDARARPYDDGVGAAPRVAVIGAGAVGCFFAAQLAAGGRAEVTVCARRPFGDLQVSSELWGTTLRAAPLVQTDPAGLQAPFDAVLLATKAHQTAGAAAWLAAATGPGTTVAVLQNGVEQVGRVRPWVPSSAVVLPAVVYCGVERTGPGRVTHRTHGWFHLPDGEAARAVAGLFPPERELVQPVADWPTTAWRKLCENVTANGVTALTGRRMEVLRDPAVQELLRGLLAEATTVAASEGAVLPPDYADRQIARVAAFPDGVGTSMLYDRLGGLPMEEDAIYGAVVRAGARHGVATPLNQALLTLLAAISATAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXR1</accession>
    <name>A0A7K0JXR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_16495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000942">
        <property type="protein sequence ID" value="MST34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="29211" checksum="58857BC5D74C83D4" modified="2021-04-07" version="1">MVLVTPLDFVVSLALVSVAAGVLGSLIGLGGGVVIVPVLTLLYHVDIRLAIGASIVSVIATSSGAAAAYVRERMTNLRAGMFLEIATTTGAVSGAYLTTLLPTRFLFVFFGLVLAYSSVVTFRRRHAAAPLVVSNDRLANYFDLHGSYYDPAEGREISYKVVGTKLGLALMYVAGLVSALLGIGSGALKVPAMDSAMHLPMKVSSATSNFMIGVTAAASAGVYFIRGQIDPIIAAPVAAGVLLGATVGARVLGRIASKTIRLVFVAVLVVISLEMLQKGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXS9</accession>
    <name>A0A7K0JXS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_16575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000946">
        <property type="protein sequence ID" value="MST34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09607">
        <property type="entry name" value="M3B_PepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034006">
        <property type="entry name" value="M3B_PepF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="204"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="599" mass="64349" checksum="54C4A35CF1AF790D" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT1</accession>
    <name>A0A7K0JXT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001208">
        <property type="protein sequence ID" value="MST34775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="15645" checksum="D32BFB388344515F" modified="2021-04-07" version="1">MPAPHTDGWACDPGWYNLDGREADGCEAHADFVPGTVLTSGTPVRANVVPLSARDAFPVRVHGSAWDLCWGALEVTLTAPARTAEAVTLWRGSTVLARAVSVDGAPATATVDKPSCFGADPEQLQARVTVVAASGDASARDFTLTRNAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV3</accession>
    <name>A0A7K0JXV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSHCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001217">
        <property type="protein sequence ID" value="MST34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSHCT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="15466" checksum="E5AB3AAC40CC2A76" modified="2021-04-07" version="1">EAMEGGLLDGLGPEELAGLVSAFTFEARGAGEGSAHLPTAALRERWPRLERLAAELVAREDGAGLPLTRLPDPGFMATAHRWAHGGELSGILEDDEISGGDFVRNVKQLIDLLRQLGDQAPDPATAAAARRAAGAMFRGVVAASSVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY2</accession>
    <name>A0A7K0JXY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaB</name>
        <name evidence="9" type="ORF">GHK86_16835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01000974">
        <property type="protein sequence ID" value="MST34379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="297" mass="32005" checksum="1B4E1BE582E18598" modified="2021-04-07" version="1">MSGADTGRPLRQRLGGFVALTKPRIIELLLVTTLPTMIVADHGLPSLRLILATLVGGTLAAGGANATNMYVDRDIDAVMHRTARRPLVTGAVTPREALVFAIGLEVAAFALLWGVVNLLSAALALGAMLFYVFVYTLWLKRTSVQNIVIGGAAGAVPVLVGWAAVRDSIGLAPILLFALIFVWTPPHFWALAFRYRDDYRSVDVPMMPSVAPLDRVARQILAYSLLVVATSLAFGWAAGAGAVYWAAAAVTGAIFLGYALRLLQEQSEARAMRLFHWSITYVTLLFAAMAIDQFVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ6</accession>
    <name>A0A7K0JXZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IF2_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001241">
        <property type="protein sequence ID" value="MST34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF2_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="92" mass="10080" checksum="39BC99AD90D24B55" modified="2021-04-07" version="1" fragment="single">MTQHLPTKRIRVYELARELGLTNKEALDLCISLGIGVKSHSSSLEDQQADRVRRKADREGLRRDVQPEEEQQPTRPAKAPAAAKAAPAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY04</accession>
    <name>A0A7K0JY04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001253">
        <property type="protein sequence ID" value="MST34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20814" checksum="3F7F742760EA8041" modified="2021-04-07" version="1">MAATVPRPTGRDLRVAVPLHQELLPDVEDLFGHLPPLNVTRMFANTGDMAAPVLGFVRAVFTAEGVDPRLREILTLRTAWILSVPYEWEANVPMARNVGVTDADITSIATDGPVTGLDATANLIYRATDEITNDVAVSDLTLQELLDVFGPTLTTKYILEISWFNLLSRFLASTRVPIDQGAPTSDRSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY30</accession>
    <name>A0A7K0JY30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymidylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_18950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001217">
        <property type="protein sequence ID" value="MST34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="478" mass="53193" checksum="FA66AC67E868C898" modified="2021-04-07" version="1" fragment="single">MAFDAAQYVTEEWTDDEAAVLRRYFTNLDGPVFALVNLPEVVKGALFARYSRSAKSLRRLFLDEFVGDLDVSGDLGVDATVGLARAEQLYDKVFFEYGDDSVAQLGGVHLACEQASNLLTKAIEWSRLMSYMEKSTRYVAYDARLGNGRYRYHRDPAVLDSPLGARFVGEMDRLFDAYAALLPDLQSHFARLHPKADGDSDFVWRQSVRAKAYDAVRGVLPAAATANLGIYASGQAYEALLVRLAAHPLPEARSYAQLMLTELRKVIPSWVKRVDVEDRGREWSAYLAETHAGMEDLAGSLFGPPPEPVAEVGGEPEVALVDWDPEGEVKVVASMLYPYTHLPETAVQDRVAAMSDAERLAVVDRYVGDRRNRRHKPGRALERTGYRFDVISDYGAFRDLQRHRLLTVEWQDLTPAHGYTLPEAVVAAGGGARYHEAMERSAALHGALQDRFGAAQAAYAVALAYRIRYAMQFNAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY48</accession>
    <name>A0A7K0JY48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_17220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001015">
        <property type="protein sequence ID" value="MST34454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="388" mass="41039" checksum="E4EF6ED29573F4D2" modified="2021-04-07" version="1" fragment="single">MSDWIDYLVCGGVAAAVTLAMTGVVRWAAVRFSIVVLPDERRVHERPTPTLGGAAMFAGFLVAMCVASQLPAFHQLFQSNSEPLGVVLAAGVIFAVGTGDDLRDMSPPAKMSGQVLAGTVLYLLGVAMLFFRIPFVHTTLVLSPDLSPVFTVAWVVVIANAVNFIDGLDGLAAGIIAIASGAFFVYSHQFLAVQGLATNVGPLLAIITCGACVGFLPHNFHPAKIFMGDAGAMLLGLLMAASTMSVVGESDVGSPGRTFFTFAPILIPFFILGIPLLDTAWAIVRRASRRSSPAVADKNHLHHRLMRLGHGQTRAVLILWSWTALLSGLVLWPVVTGHDSIAVPAAVGALGIVLYTVFARGRKATNVLEVPCRITCGGRRRCAACPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY64</accession>
    <name>A0A7K0JY64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline iminopeptidase-family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_19435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001277">
        <property type="protein sequence ID" value="MST34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="186" mass="20075" checksum="E2553E1A3E35FAD8" modified="2021-04-07" version="1" fragment="single">MERVQDGTVGVAGGETWYRVTGDPGSGTPLVVLHGGPGSTHEYLLTLAALAGDRRAVVHYDQLGNGRSSHFPGRGAEFWTVQLFLDELDAILDALGISGAYHLLGQSWGGMLAAEHAVRRPAGLRSLVLADSPASIPTWVAEADRLRKELPPEVQRVLDEHERAGTFDSAAYATASQVYYDRHVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD1</accession>
    <name>A0A7K0JYD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxyacyl-ACP dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ</name>
        <name evidence="1" type="ORF">GHK86_19860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01001332">
        <property type="protein sequence ID" value="MST34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="147" mass="15254" checksum="3850B981CD231048" modified="2021-04-07" version="1">MAGTGPGPLPDPAGVLPHRPPFLFVDRVTELVASTSAKGEWRLTGEEAFFAGHFPGRPTLPGVLMVEALAQLGGIAVLADERFAGKLPLFGGIDKARFRRQVVPGDLLELEVTLGQLGTSAGKGTGVARVGGQVACQASLLFVIVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYW8</accession>
    <name>A0A7K0JYW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001464">
        <property type="protein sequence ID" value="MST35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="14928" checksum="3B8A834B94C19F77" modified="2021-04-07" version="1">MAFPFLSDEWIEEARRIRAEYEGRAPEAPVALRVNVVVTDVPWEPRRVEGYVDTTGGTVSLEVGRLDEADATITLEHATARAILVDGDRQVAMAAFLGGRIRVDGDLTKLLALQMNPAPLDPVVGEVFTRLRDITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX6</accession>
    <name>A0A7K0JYX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001470">
        <property type="protein sequence ID" value="MST35150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="8992" checksum="2ADA5CC89FFEF9CB" modified="2021-04-07" version="1">SGLVMWAYAQAGISLPHFSGAQYADTVHIPMSALQPGDLVFFSNPGEHVAMYVGNGMIIQAPYTGAFVEIVPMYPGFTLASRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX7</accession>
    <name>A0A7K0JYX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1906 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001467">
        <property type="protein sequence ID" value="MST35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="244"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="554" mass="55305" checksum="713A35ECA4090258" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ04</accession>
    <name>A0A7K0JZ04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_20925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001498">
        <property type="protein sequence ID" value="MST35183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="27991" checksum="26A519CA48222058" modified="2021-04-07" version="1" fragment="single">MQPTGTGGPTIAGRYRLGARLGRGGMADVFDAHDERLDRPVAVKLLRPELSADPGMRARFEREARAAARLNHPNVVAVYDSGEDAGRAYLVMERLPGESLADRMRAGRVGPDWLRGVAGDVLAALGAAHDRGIVHRDVKPGNILLDPEGHAKVGDFGIAKAIRSAAAGDPTDPATADLTAVGMLIGTVAYLAPEQVEGAPATPQSDLYSVGVVLYEALAGRKPYPGGDEPVAQARAVVEGGAPDSGVEGRQRVLEHHAERRAEQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ56</accession>
    <name>A0A7K0JZ56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_21225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001546">
        <property type="protein sequence ID" value="MST35240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IGPS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="46" mass="4316" checksum="697BE54A4D3EF626" modified="2021-04-07" version="1">AESGVGGPGDVARLAAAGYHAVLVGESLVTAADPAAAVAALREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZK1</accession>
    <name>A0A7K0JZK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001609">
        <property type="protein sequence ID" value="MST35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="287" mass="30543" checksum="3734605AAFDCC97B" modified="2021-04-07" version="1" fragment="single">PVTPVDVAVVGAGPAGAAAAITAARAGLRVHVVDRAVFPRDKTCGDGLTTGALRRLERLGLDPWRLPSWQPVRTARVRIPDGRVASLDLPDPDRVRAATVRRLELDAALVRLTRAAGAEVEEGRTVTGAATAAGGAGVELTLQDGSTLQARYVVAADGMWSPLRKALGLADDGYLGEWQAVRQYHRGVGPAARDFWVWFEDDLRPGYAWSFPLPEGRANVGFGVRRVPGEPTGNLRERWAEVLQRPPVASVLGPGAEPEEPVRSWPIPARIGDTALAGLGGRVLFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZR8</accession>
    <name>A0A7K0JZR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001678">
        <property type="protein sequence ID" value="MST35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="383" mass="39340" checksum="5488E2E593C86A27" modified="2021-04-07" version="1">MTAEARPARRRRWWRRPMLWALVVVLALVAAAVGWAWNGASGYYTYEPGDALPVTASTGCTTSGGNPHLPGGGLCARLVVPADRVHPVAGKLLMVDVLVGQTTPWQYALARLGLLDTFQRAAELHSARDVLGGAPAGQFTCQGVQEMDQATTDAPVAALRRLGYSVKATYHGSQVFLVQAGSPALKGGVRCGDLIVAVDGRPTLTAGALVRAVESHAPGTVVTVTVHRSGSGGHTVTRRVQVRLGSRPGDPKAGFLGIATQDLPTYKLPFHVGIDVGDIGGPSAGLALTLGLLDALSNGHLTGGHTVAVTGTIASNGAVGPVGGVAQKTVAVERAGATLFLVPAAEVATARREARPGLKVEGVTSLAQALDDLRAIGGTIPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMG2</accession>
    <name>A0A7K0JMG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_00015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000002">
        <property type="protein sequence ID" value="MST31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="19899" checksum="3C81F2C4D1498DCB" modified="2021-04-07" version="1">MSPAVVLVSFPIVFIGELPDKTMFASLVLATRGRPLQVWLGAAAAFVAHVAIAVTVGVALFALLPHRAVEAVVAAAFLAGAVLSWRMSRSGEEETVERVPTARSAMLSAFAVIFVAEWGDLTQILTADLAARYGAPFSVAVGAVAALWAVAAIAVTGGRTLLRFVSIRRIRLVTAGVLVVLAGYAAWSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN06</accession>
    <name>A0A7K0JN06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="235" mass="23974" checksum="7DD88F45AFD00678" modified="2021-04-07" version="1">MTGGSGGIGSAVARRLAAEGAAVVVHYGGSAERAAELVEEITAKGGVAVAAGGDVAEEGDMAAVFGLAEERFGGLDVVVNTAGIMLLAPLVDLDLADFDRMHRANVRGTFVVSQLAARRLRKGGALVNFSTSVTRMAPPTYSAYAATKGAVEAMTLILARELRGRDVTVNAVAPGPTATALFLDGKTDQQLAQLAAAPPLERLGTPDDIAETVAYLAGPGRWVNGQVVYVNGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN98</accession>
    <name>A0A7K0JN98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000049">
        <property type="protein sequence ID" value="MST31373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="16201" checksum="006B1D3DEB1366C5" modified="2021-04-07" version="1">MIAPVASPVVLSWLERGQTTQQINDLTGRTKVWEGVVTESRPLPNVVLGSGMSNDAFNGLPIDDSWLAIYQDQGLFGDAVMAAMLLVLLLVAATRPRGPARAVALFLIVYCIPASITETGLGQANPYMLDLFVAASLLVSSPRHRQLRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE0</accession>
    <name>A0A7K0JNE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000064">
        <property type="protein sequence ID" value="MST31423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="308" mass="31268" checksum="E509A67388DC1F4D" modified="2021-04-07" version="1">MSQAIVYESFGGPEVLELRDVPEPHAGPGEIRVRVTVAGLNPMDWGISSRPEAAARFGISAPSGFGSDFAGVVDEVGNGVTGFAVDERVYGAAMARAVAQFAVLRPPADPVWHTPDEMSDEVASTLPVSGLTAFAALEAIDPQAGDTVLVGGAAGGVGVFAVQLARLAAAHVVGTASEGTFEFLRQLGAEPVAYGPGLADRVRVLAPGGITAATDLFGTEAAEAALALGVPAERISTIAALANPVPGVRATGAADASPDAMMRIANGIVDGSITVPIAARFPIEQTIEAVRLQAGRHVHGKVVITLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNH0</accession>
    <name>A0A7K0JNH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_00135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000005">
        <property type="protein sequence ID" value="MST31139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029606313" evidence="2">
        <location>
            <begin position="24"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="541" mass="58407" checksum="1E7C5980CC9B4769" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK2</accession>
    <name>A0A7K0JNK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000012">
        <property type="protein sequence ID" value="MST31169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="11629" checksum="D775E5CDA37794C0" modified="2021-04-07" version="1" fragment="single">MGRTGPRCRFDHTVAGSRESLELVDPVGELVAWEPGEVVGVLEEAERRAAGGCWLGGFVAYEAAPAFDPALGVRADPPGGDRPSLPLAWFGVYRGSGVPSPGDPVASGEPGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP3</accession>
    <name>A0A7K0JNP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="340" mass="37123" checksum="A387C8053C306BDC" modified="2021-04-07" version="1">MNCVLVLLLGRDQILRRRRAVAPLDRRLPAGVDGLRRAAWIGLQDSVPRAALLSIHARVDGTTSESWEDPSLVQVWGPRYSVFVVAAADLALFTVALLPDDRRGRERAERLAAQLHDLLAGGVESLDEAGRRAGVHPNAFRYAAATGTLLIRWDGARRPTISACPPPATDPGEARLELARRYLHVLGPTTAASFARWSGLSASSSEAVFSALRSSLVPVSTPLGDAWILASDEASFRAEVRPRGVVRLLPSGDAYFLLQGPDRELLVPDPDHRAELWTPRVWPGALLVDGEVAGTWRRAGRRVRVQAWWDLSAVDRERIAEEVMALPLPEPSPAIIDLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNP5</accession>
    <name>A0A7K0JNP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000101">
        <property type="protein sequence ID" value="MST31586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="451" mass="47678" checksum="3F9F4853CA388A6B" modified="2021-04-07" version="1">TFSSNGSTTVTDDIQEVDPAADSARIVGHLHNAFYGAAAFPIGRALYLAGGQIPGGPTLTGITAYVPSSGKLLQAGLLPQAVAFGGYTTVGSGSSAIGYIVGGEVTSQTGRNAAGVASGQLSTVISLRPSPYGGPAGTTAAGMPYRGTLLIADRGNDRLIAITPTRRRIWVYPSPSMPTPNGGFYFPDDAFFIRHGTAIISNQENNDTIVEIGYPSGKILWEYGHPKVPGSLPGYLFQPDDAYLERSGIVTVADASNNRILFINPTTKAVVGQIGNGTDAHVPGVSIAYPNGDTPLANGDVLVSEINGSYVDEYTPTGKMVWSVQMKSVNYPSDPQQLGPDRYLMTDYDPPAEGRILEFNRAGQILWRYDATSGDGRLDQPSLAERLPNGLIMVNDDYNDRVIAIDPRTNSIVWQYGLTHTPGTAPGMLSVPDGFDLLLANGTTPTHPQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNU2</accession>
    <name>A0A7K0JNU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_02405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000100">
        <property type="protein sequence ID" value="MST31583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="322" mass="34753" checksum="27527C6F978A1070" modified="2021-04-07" version="1">MLTFALRRFGAAFLVLFAISVLVFLIFFATPGVDPAARIAGRSATPQILAQVKAEFGLNRPLPIRYLLMMKHLFITRDLQSYVNPGQKVIPEIVAAAPVTLSLVIGAAVIWVVFGVLGGLLAASHKGSFIDPVIMLVGIAAVSVPGFWLGEVVNLITQGNLHNSVFSWVPPPGYVSISAGVGQWALHLLLPWLTLAVLYAGIYARVLRAELVTALDEDYVRTARAKGLSERRILFRHALRCSLIGIVSLFGLDFGSLVGGAALLIEVVFNLHGIGWLTYNALQDLDLPVIMAAVLYGAFFVVLANAVVDLLYASLDPRVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ0</accession>
    <name>A0A7K0JNZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000114">
        <property type="protein sequence ID" value="MST31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20942" checksum="1FC925D07E334C8C" modified="2021-04-07" version="1">MTSGDDPGGASHPLDQLAQIIGACFDPTTFDTGTFETGAFDGHGFDTGELDDVAAPTHWPSLPSADSAAEWTELRAWVEALQGRFAHLDHHVIPRCWWRHNDHVEALAALRDHERSSFAPTAPATAPLDWFRAQRDIAALLKAWTADLGCAAAHTDPPTPLRAVDNREWERFVTDDVARRREAEIEQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ5</accession>
    <name>A0A7K0JNZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nuoL</name>
        <name evidence="10" type="ORF">GHK86_02525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000105">
        <property type="protein sequence ID" value="MST31607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="9">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="135"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST31607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="658" mass="70579" checksum="2E872FB87100132F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP83</accession>
    <name>A0A7K0JP83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000131">
        <property type="protein sequence ID" value="MST31776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="128" mass="12992" checksum="272CA15F1276F425" modified="2021-04-07" version="1">AVTIHARRSPHRYPWVEEFGAATAERLGLAAHPGRLSMELRPPVAVDKGTVVASLSEGMAAACYIGDDRGDLPAFAALDRCRAAGMATLAVAASSDEAPAELLGAADLVVDGPEGTLALLTTLAGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP98</accession>
    <name>A0A7K0JP98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000139">
        <property type="protein sequence ID" value="MST31800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="273" mass="28484" checksum="18D4CB78991613AF" modified="2021-04-07" version="1">MTALAPPPQAVAAAPPAGRRGPLDRAWPPVALLAALVAVWEAVTAGLRINPTVLPGPVLVVTGTWSERAQLLPAMATTSLEALLGLALAAVVALPLAVSIDAWRGVRSSVYPLIVASQTLPVIVLAPLVVIWFGFGLWPKVALVALFSFFPIAVGAVQGLGSADRDVLDLLRTMRASRWQLLTKVKLPSALPQVFTGLKISVTYAFTSAIVAEWVGATSGLGPFMTAAAQDAPRRTDVVLGGTVVTAVLTVALFAVVAALQRAAMPWRPRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ6</accession>
    <name>A0A7K0JPJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000144">
        <property type="protein sequence ID" value="MST31817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="456" mass="48559" checksum="48A0AD1E7AD0ADCA" modified="2021-04-07" version="1">MVTASPHTDERIEAVVAEQERIFVERQPGSASRAARAGAVLAGGVTSSWQITRPQPVWLSHGAGSKIYDVDGGEYVDLHGGYGAGLAGHAHPAIVEAVQRQVARGTHFAQPTDDAIAVAEHLAGRFGLPLWRFCNSGTEATMDAVHLMRAFTGRDLIVKVEGCYHGHHDSVQVSVTPDVGDVGPADRPNQVPASTGIPAAIRDLTLVVGFNDLDAVARLLEEHRGQVAGMILEPIMMNAGIIPPVDGYLAGLGDLLHAHGALLTFDEVKTGLTVGPGGATARFGVRPDLVTLAKSIGGGLCCGAVGGSAEVMGFVAEGGYDMVGTFNGNPLTMAAIRAVMEHVSTPDAYDRIATLHHRIETHLDDSLRRHGLVGKPVVAGAKGCVTFLDRPVRDYRDFLEVDDRYNHAHWLFQHNGGVFLPPWGKTEQWLLSVQHDDADVDRFLANFDRFAAAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPR0</accession>
    <name>A0A7K0JPR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11451" checksum="F4EEA80E4A61F549" modified="2021-04-07" version="1">MAVVASAHAPGFTARQVVKLAATGVGEEILWRGAIWTALTRATSRLAAVVGLDVVLFVSWHVPSVLAGDNTWSGLPVVAALGVTFCLARLASRRIELPALLHIAADLLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPW0</accession>
    <name>A0A7K0JPW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000175">
        <property type="protein sequence ID" value="MST31927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="94" mass="9972" checksum="EAE64E006AFE2B2F" modified="2021-04-07" version="1">MATARATTTIDDDRVRVTVWTFDGDGDETGQHEHQYDYVVVPVTGGSFTVLGPDGAVSRRTQEAGVPYHGAAGTRHNVVNAGGAPATFVELELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX4</accession>
    <name>A0A7K0JPX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000185">
        <property type="protein sequence ID" value="MST31961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="23937" checksum="883327A9E2558B82" modified="2021-04-07" version="1">MTDSIANDGPGSDGLAPPVLLGEAERFRRKVRRAGRNGWVAFAVLAVLTAGSLPLYAAPKAPGAGSSTSVSALWPLGVALGGPFHTSPFAVALYWLAGGTVGFVVVAAWYRLAGRRRGVAAPVARYVTIGVALLAALGVAAAVGVLGPGDLTVRGLLPLTVLVAAVLVLARAEHDPVLAAAAVVLVALSLIGDLYDLSNLTARAGAGTLGLSAPQVNVAAMAAGLAVAAAAVGAVTARRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPX5</accession>
    <name>A0A7K0JPX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_02560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000106">
        <property type="protein sequence ID" value="MST31614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="714"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="205"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="607"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST31614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="782" mass="79843" checksum="81A5CD027ED6567F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ34</accession>
    <name>A0A7K0JQ34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000199">
        <property type="protein sequence ID" value="MST32031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="50" mass="5424" checksum="0920492E79780AA6" modified="2021-04-07" version="1" fragment="single">MTDRNDRSTERRPAEGVRIIGAEEAQAALEAGQAAGRLTEDELRFGDVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ70</accession>
    <name>A0A7K0JQ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_04895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000203">
        <property type="protein sequence ID" value="MST32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7686" checksum="348F108731A74838" modified="2021-04-07" version="1">MTGGGRSAGLQRAPSPEELAAIVAAVEAAWPRPVAAAATPEALPTRWRFSGRWWSRPTISRRDRPWVGPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ92</accession>
    <name>A0A7K0JQ92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_04915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000203">
        <property type="protein sequence ID" value="MST32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="158" mass="16458" checksum="9E47E0575984EE8A" modified="2021-04-07" version="1">MKTTAGTMKIQLLPRYAPVTVNNFVFLAGYHYFDGIVFHRVIPGFMNQGGDPTGTGTGGPGYEFKDELPKSAAAYDAGALAMANSGPNTNGSQFFITVGKGGQQLQPSYTMFGQVVSGMSVDDKINAGGNPNPSANGVPPKTLYKILSVSISATPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQD7</accession>
    <name>A0A7K0JQD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000228">
        <property type="protein sequence ID" value="MST32165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="324" mass="34350" checksum="647295A6A048D4B1" modified="2021-04-07" version="1">MHPGGRGRRCVVTGSAGFIGSTLCRRLAREGWVVIGIDAFTDSYDPVEKVLRAASLTQVAGTSLIVGDLAELDLERAFDGAEVVFHLAGRAGVRPSFSAEDRYVHDNVIATERVLEAARRAGVRRVVYASSSSVYGDGDAPFREDAAPNPISPYGRTKLEAEERCLAASGPDLEAVALRYFTVFGPGQRPDMALRLFAEAALAGRSITLLGDGTQRRDFTYVHDVVAATAAAADAPVGGLAVNVGGGSSVSLLEVLDLLGDLVGAEPTVTVQPVARGDVRVTSADLTRARDLLGFEPRVPFAVGYERQVAWLRQHAGQAMERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQE8</accession>
    <name>A0A7K0JQE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000231">
        <property type="protein sequence ID" value="MST32175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="501" mass="55735" checksum="90F89C77F8844C26" modified="2021-04-07" version="1">MATIEGYCERLSYAPGEVVSVACRTRAGTFAAEVARVGAEREIVWYGDGLPGRWQEAPARASEVGCSWEPSFTVPLPADARSGYYEVVLRARDEVDGRLDEGRACFVVRPGAPPHRSRVLLALSTNTYNAYNDWGGPSLYTGATRASFRRPFAPGFLVKPEPHVRYPDVEDIDDPEHEHFRRWADLHGLARWSGSSGWHNWERPFVRWAEREGWQLDVCTNADLELHPEVLDGHRLVVSVGHDEYWSWGMRDRLEAFVEAGGNVAFFSGNSVCWQVRFEDDGATMVCYKAAYEDDPAYRGGDRQRTTTMWCSGVVGRPENHLTGLSFSRGGYVRMGRAVPRSSGAYTVWRPEHWVLEGTGLRYGDPFGDRDRIVAYEVDGCELAASPEDGRPVPTGRDGTPEDFTVLATAPARLWSGDELPSRYRTGEPSDLEWTAAEVFGDASPEHVARLAYNHAVMGVFTRGGTVFNAGTTDWAYGLAGRDPFVERITRNVLDRLAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQG3</accession>
    <name>A0A7K0JQG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000140">
        <property type="protein sequence ID" value="MST31809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="4">
        <location>
            <begin position="5"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="318" mass="33474" checksum="5553B9AA6F40AFE7" modified="2021-04-07" version="1">MADDVLVLAEHSEGVLADHTFELLGKAREVAGAWGGSTRVALLGPAQLAGELGGADVVHVADHPALSHYLPEAYERILTRLVEQVQPRLVLMGTSTPGMDLGAALAVAWDAPVSAYTVDLEVEDGTLVARAQIYAGKLMAEVAIDAPRAVCTVIAGSFPAAAGRVEGQPQVEPVATGELDSLRSSFTALRLPETGGVDITTADMLVSVGRGIGTQDNLEVVQELADALGVPLSASRPIIDQGWLPKPHQVGKSGQKVKPRAYLSFGISGAPEHLEGMRNAELIISCNTDPQAPIFDVAHYGCTLDLFDLLPELVERLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI2</accession>
    <name>A0A7K0JQI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GHK86_05640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000245">
        <property type="protein sequence ID" value="MST32208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="44"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="383"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="417"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="650" mass="68090" checksum="CE80F4FD7556243E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQI8</accession>
    <name>A0A7K0JQI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000246">
        <property type="protein sequence ID" value="MST32210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11398" checksum="3D753EDC98482BB5" modified="2021-04-07" version="1">MLPEQVLSAVAHEDLPVLDTVFHMHLASMESCDLDARTFHLVRLAALVAADAPPASYLVHLPMAADAGVSLEDAQGVFVAIAPLVGTPKVTAAAGNVLRALGMAEALDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQJ6</accession>
    <name>A0A7K0JQJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ispG</name>
        <name evidence="6" type="synonym">gcpE</name>
        <name evidence="6" type="ORF">GHK86_05660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000247">
        <property type="protein sequence ID" value="MST32212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="399" mass="41871" checksum="82552E2E86EE75C0" modified="2021-04-07" version="1">APISVQSMTITKTADVEGTLAQIYALKAAGADIVRCTCNEKEAAEGLARIVPRSPVPIVADIHFHVEMALAALEAGVDCLRLNPGNLRKPEEIKLVARECKDRGVPVRIGVNAGSLDPRLAKKYGGATPEALVESAQIELGLFAEVGFDDVKISVKASNVPLMIEAYRQLSETVDHPLHLGVTEAGPPPAGTIKATAGIATLLAEGIGDTIRYSLTADPVEEAKAGRVLLEALGLRERTSVDLIACPACGRAEIDVYKVAQEAQAALETRSIPLQVAVMGCVVNGPGEARSADLGIAAGRHRGHLFIQGQIVRVVPEDEMVAALVEEAEKLVEEGVAARLAAADKGAAGEAEKDRRALLDAKGDDANHSEDRVDLIEKRLRAAADGEGPTDWKDGPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQK4</accession>
    <name>A0A7K0JQK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000157">
        <property type="protein sequence ID" value="MST31864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="109"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="255" mass="27325" checksum="E3B2F84838E7C615" modified="2021-04-07" version="1">MSSFFHRAKDIVNAKANRALDAAEKPDEMLDYSYEQMLEQITKVRKALVTVAASRKQLEMQEDQLKHSADTLTQQAQQALAVNREDLAREALSRKQVVQQQIAGMDPQHQQLVEQQDKLTATLQALQARVNQFRTQKETMKAQYAASTAVSSVDNQVAGISDTFNNSNAALQRAQDKIAAAQAHAGALDELLESGVLDDVGASHGDDIQRELDQLGATSSVDSELAALKAQAGLAAPAAPAALGSGDEAGTDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQL5</accession>
    <name>A0A7K0JQL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_03895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000158">
        <property type="protein sequence ID" value="MST31869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="211" mass="22859" checksum="F73E1636759F5AB9" modified="2021-04-07" version="1">GVAVVTSEDTASWTEFLRSLVDRGLSGVELVISDAHGGIKAAIATVMTGSSWQRCRTHFMANLAARVPKSSWPMVATLIRSIFEQPDAEATWTQLETVVDKLTSTGFADAAGFVLAAAEDILAFTAFPVEHWPKIRSNNPQERLNKEIRRRTDVVGIFPNRAAVTRLVGAILAEQNDEWAVTKRYMRPESLKTAATALAASPPAADQLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ0</accession>
    <name>A0A7K0JQQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphosulfolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_06020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000262">
        <property type="protein sequence ID" value="MST32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="SSF102110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="26203" checksum="809C4831691CF36F" modified="2021-04-07" version="1">MVLDHGLSVASFADHLRSTAELVDLVKFGWGTALVTPGIEDKIAVAHELGTRCYLGGTLFEKFVAQDRLEAYLDLCERLGVDLVEVSNGVIPMANTAKAAYIRACAERFPVVSEVGFKDPDRSLRFSPSQWVGAIAEDLEAGAWMVTTEARESGRSGICRADGELRYGLIEDVIASGLEVDRLLFEAPTKDLQSYFVTRLGANVNLGNVAPGDVVGLETLRLGLRADTLLHFEDQRRCADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR14</accession>
    <name>A0A7K0JR14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000201">
        <property type="protein sequence ID" value="MST32044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="2">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="267" mass="30050" checksum="FE60BAB4F72D58FE" modified="2021-04-07" version="1">MTAPAPTVSNELKTLLRGVKLGRCLDTLPERLALAKQRGLSHHEFLELVLADEVTRRETSSASLRARTAGLDPDMTLENWDATTKVNYDHQTFDELCSLRFIDAGHNALILGPVGVGKTFMATALGHAAIRRRYSVSFCRADVLLKRLRASRLDNSHDAEIRKLLRVDLLLLDDFALQPFDALDTADIYELIVERHRMASTIVTSNREPVEWLAQMADPLLAQSAIDRLQSAAYEVILDGESYRQRQKPGLDTGTINPRPRRRRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR41</accession>
    <name>A0A7K0JR41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_06740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035169">
        <property type="entry name" value="DUF5318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17249">
        <property type="entry name" value="DUF5318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15613" checksum="35558AE7055453F6" modified="2021-04-07" version="1">MGFRPESLRGASAAGQVAGQVDYRLARNAVLSEFRKGRLSRLDLCDAHPELLRAACNVGEETREDCPICEEAKVRLVSYVFGPRLPPSGTCVSTKAELAKLSRSQRDLACYVVEVCPSCSWNHLAQTFAVGGRGRQADRRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR42</accession>
    <name>A0A7K0JR42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_06510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000280">
        <property type="protein sequence ID" value="MST32373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="263" mass="27484" checksum="15F7E9E4E187D98E" modified="2021-04-07" version="1">MLASQRRRRIAEELARAGAVRVADLAIALDVSEMTVRRDLERMQEAGVLVKVHGGAVPAGRSAEEPGFDVKLERATAEKSAIAKAAVNLVPPGSSVALSGGTTTWSLARLLPSVPGITVLTNSLSAATELHRQRPAPSVVLSGGVRTPSDALVGPIADAAIRSLYVDLLFLGVHGMDPDAGYTTPNLAEAETNRTFVANARRVVVVADASKWRTVGLSRIAPLEAADVVITDEGLPLEARRALSEVTELVVAPLGPGSIREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR68</accession>
    <name>A0A7K0JR68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_06695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000287">
        <property type="protein sequence ID" value="MST32407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="174"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="268"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="386" mass="39795" checksum="083EB6FFC24A7ECE" modified="2021-04-07" version="1">MTTDHPAAPTPEGQAPQPPTRRRGRRLLTRYALLWGVPVAAALVWVAVWSPPSTSAASVTTAGANGSGYPSYTFKGTSRPGYPSYKGVTGRSPGPPATSGLSGLSGELQVSGTTGGARISHAYGRYGKGAELRTQVNGVYRISSLAKARTAATSILRSGEKAQTDEGTPGAISHGTINAAMIFQDHCAACHGETARGTVRGPSLVGVGEAMVDFQLSTGRMPKEVYGHRPEPYTPILSVLEIKALDRYVTALAAKGGPSIPSVNASIGNIAQGGVLFRENCASCHGWGGAGGELVNRPVPRITEATPLVLGEAVRSGPAQMPVFGTEVISKSGLNDVAAYLNYIKHPDNAGGNGLSHLGPVASGAVAWIVGALLIVAAMRWIGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRB8</accession>
    <name>A0A7K0JRB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000304">
        <property type="protein sequence ID" value="MST32472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="182" mass="19771" checksum="284BA98840620304" modified="2021-04-07" version="1">MTTTTSVTGDYTLDMSHSTIGFTARHAMVTKVRGRFADVAGTGHFDVDDPARSRVEVVIQAKSIDTGNADRDNHLRSNDFLAMDEFPEIRFTSTSVERAGDDRYTVQGDLTIKGVTKPVAIDFEHTGAATDPFGNQRIGFEGSTTINRKDWGVNWNAPLEAGGVLVGEKVTLEFDISAVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRJ1</accession>
    <name>A0A7K0JRJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4129 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_07510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000332">
        <property type="protein sequence ID" value="MST32568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="189" mass="18835" checksum="A0C1AF1D09E0BEE3" modified="2021-04-07" version="1">RTASPLPPAAGSVGSPGGLGWLLVAAAAAAVAVAALAVWRWREWAPHRADASLAADPVGVPPAPGPAVPDVEAALRALDGETDPRGAVLACWLRLEDAVAATGAARAPAETSGELTRRVLAAHAVDPGGLARLHSLYLLARFSPAPVDPGAPAEARRILQGVSAQVGSGRAQVDDALPQGDVAGAGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP3</accession>
    <name>A0A7K0JRP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000255">
        <property type="protein sequence ID" value="MST32249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="224" mass="24438" checksum="61F0924D3C248529" modified="2021-04-07" version="1" fragment="single">MSGQRRQAATATSPSSGKPSAPPERRRRRARGDLDRQLIVEAALAVSARGDGYEGLTFQALGAELGAHPTAIYRHFRDKDELMLALVEALHAEMLATLPPPSDDWAADLRLMAVRSYEVFLRFPAISQVATVRTSRSEHEFQVVERILGCLRRAGFGDADAAVYYRVFAEALLGHVALDAGFAALRPATREGDLRAWLVNYRSLPAERFPNLAATAALIPAVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRP8</accession>
    <name>A0A7K0JRP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000339">
        <property type="protein sequence ID" value="MST32605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="387" mass="40707" checksum="6B03B7D15D420992" modified="2021-04-07" version="1">MFAGCGLNNFSRTGKLANTATIYRSSDAGRRWQSWATFRQTYTGMGAEPSWAPLAASPQGNILYFTQNIWDGQLRALTPGATALTTPAKVGLVYGIDQLSAQDAWLLAPAQGIWATDNAGHSWNLITTSATTAAGSSGGSGPGLPAGWQKATPQQVRAAWIPQHLARRFSYLATWTVIPIGAHPQTTTVTSGRAADGAWFYRITPASAVAGLLMPHDVAIGGTYAYYFHPGTTNAQVSCTTHPTQPHTWTCASWTNLSIDMSVDSALQGPDPAASAGAAVGNLLAAYGYNQASSGPPTTPAYLAHPHRLGLALTCVRFGSPTHPRCPFCTHDGLVISYQLPQGVPNLDGGVDYSSIRVTSYQPAPPAANLHLPAPLTPPLTPPPPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR1</accession>
    <name>A0A7K0JRR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000348">
        <property type="protein sequence ID" value="MST32638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="9829" checksum="4816384D1A394D4C" modified="2021-04-07" version="1">MILPTQKWVRGRRRRLTVAAVRNPTVSIPEELDDAIRAEAYRTGRSRHEVLVTWLRETWPEHVRDQLRADLTTDLDADVESHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRR9</accession>
    <name>A0A7K0JRR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NUDIX-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_07850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000347">
        <property type="protein sequence ID" value="MST32632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDIX-like" evidence="4">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10071" checksum="4A45BA752E574337" modified="2021-04-07" version="1" fragment="single">MRYAGRVPFVPLTTPPEPAPDAAAWLVVREGEVLVVGEEATAAPSPPGGSPGWPAALPAELEAATDTDPVFLGVEGGRACWAQGVGAGTPAPTGTRWVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS6</accession>
    <name>A0A7K0JRS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000350">
        <property type="protein sequence ID" value="MST32641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="144" mass="15773" checksum="42D2691A77B0105A" modified="2021-04-07" version="1">MTTTKQMIEHAVELYNAGDVDAFLELYADDAVLTLPEGTYRGRDAIRRSFVEQWTGFPDSHISAELIVAEGDTIAEEFTYQGTNTGPVAMPDGNTLPASGRHVEMKAMQLIKTRAGKVVRHDIFLDTGTMAEQMGWSHPGSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRT5</accession>
    <name>A0A7K0JRT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_07800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000345">
        <property type="protein sequence ID" value="MST32623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029610129" evidence="1">
        <location>
            <begin position="34"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="53"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="312" mass="32553" checksum="A1DC7C2C7C0235E5" modified="2021-04-07" version="1">MSRPTTRLLRRAALTAAGFLAAGSLALPGIASAHPAHHPPGVAPVVAGSDYLALGDSVSFGYREPDTTPAPVYTDQAQFVGFPEQVAAALGLHVANLACPGETSASLINPAAPSNGCENSYVNGKQQPVGYRRSYPLHEQYRGSQLAAGVRYLRSHPHTRLVTLMIGANDGFLCQAETADHCTSPTELAAVAKTIATNVGRILFTLRVTAHYRGQIVLVQYYSTDYAVALDNQQTELLNAAMEAGARPFHVEVAPTFAAFGAASRYSAADPCTAGLLTQLTSGGKPTGSCGVHPSPAGQDVLAQTVEATVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU5</accession>
    <name>A0A7K0JRU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000348">
        <property type="protein sequence ID" value="MST32637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="10214" checksum="55631863A8371C26" modified="2021-04-07" version="1">MRAGDREAMVMRVLGPGGDEVVVVRGSRQRQLVAQHRAAVEGVLAGRVDPVRLERFRGKTVGGVELETDVDRLAVLFELGRMNGGPYPEVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS30</accession>
    <name>A0A7K0JS30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_08420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000378">
        <property type="protein sequence ID" value="MST32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="167" mass="18673" checksum="CA33571F9DF93ADF" modified="2021-04-07" version="1">MPDICDLILDEHEHQRRRFAELDEVRDAAADVLARRWEPLATLLERHAAAEEAIFYPALLQVGVAAEEETEDAISDHNDIRDAVRRANGVEPGSEEWWQAVRAAREANSDHMGEEERGALADLRAHDDAEGRRALGDRWTAWSAAHADGSGVPDHDRDPDAYIRGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSN6</accession>
    <name>A0A7K0JSN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4280 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_09510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000441">
        <property type="protein sequence ID" value="MST32952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025460">
        <property type="entry name" value="DUF4280"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14107">
        <property type="entry name" value="DUF4280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="11822" checksum="EA53DF72BFB18DA2" modified="2021-04-07" version="1">MGGACSCSFGAAPATIMVLPTNRVMIQGRPAATISDSTLVNVPTFGVCNTLTNPTVAAATAAALGVLTPMPCLPVLTPWIPGSPTTLLGGQPALTVGSTAVCAWGGVVEITVPGSTTVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT00</accession>
    <name>A0A7K0JT00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_10050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neocarzinostatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000471">
        <property type="protein sequence ID" value="MST33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027273">
        <property type="entry name" value="Neocarzinostatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002186">
        <property type="entry name" value="Neocarzinostatin_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00960">
        <property type="entry name" value="Neocarzinostat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="139" mass="13789" checksum="50CD61E538EA8DD2" modified="2021-04-07" version="1">PGSGTSGTGTSSTSTAPSTTTSSTTPPAGAQQLQVQPDAGLAATQTVHVTGTGFSPNEPLVVAECAAKGAATGPDDCNLAGMLPVTSDATGRVSVDFTVVKGPFGVNKIVCDASQQCLVSVNQATPKPTQQASRPITFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT24</accession>
    <name>A0A7K0JT24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000487">
        <property type="protein sequence ID" value="MST33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="222" mass="22822" checksum="F3DF051DBC0A80F4" modified="2021-04-07" version="1">TALAAAGAAVMLSARKPGPLEEAAAGIPGTVATFPANAGDPDAAEACVGAAVERFGRLDILVNNAATNPYFGPLIDIDLPRWDKTLAVNLRGPLVWTQAAWRAWMRDHGGTVLNVASIGGLRPGGGIGAYDVTKAALIHQTRVLAEELGPGVRVNALAPGLVRTDFARVLVETHGDAVAERLPLRRLGLPGDVAGAAVWLVSDLAGWVTGHTLVVDGGAVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTI4</accession>
    <name>A0A7K0JTI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000536">
        <property type="protein sequence ID" value="MST33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="177" mass="19759" checksum="5FD0DD0F129A45DC" modified="2021-04-07" version="1">MRSLTYELAQEGQRDELLTTGEAAKLLNVSRQHIVDLCTNGDLPFSTVGTHRRVRRADLVQLRSRTERLTRDQERSLWLGHAIAGKLVADPTGVLARAQANLAQLQARHPRGQAARWLDEWGRLLSGPTAAVLDALTSRSLRARELRQNSPFAGVLSDEERHQVLAAFGESQGRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL1</accession>
    <name>A0A7K0JTL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific DNA-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000539">
        <property type="protein sequence ID" value="MST33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="305" mass="33739" checksum="18DE1BD9B817AF8A" modified="2021-04-07" version="1">MIDLDVGSDYVILGDNAAVLPTLPAKAFQLIYLDPPFNTGRTQQRRTLRTVRSADGAGDRVGFAGRSYTTLESGRHAYGDDFEDYAGFIEPRLREARRLLADDGTLYFHIDYREAHYCKVLLDGIFGRECFLNEVIWAYDYGGRPKRRWPAKHDTILVYVRDPDGYHFDQEAVERIPYMAPGLVTPDKAERGKVPTDVWWHTIVPTNSREKTGYPSQKPEGILRRVVQASSAPGSWVLDFFAGSGTTGAVARQLGRRCVLVDDNPEAVAVMRRRLGGESVRYVAVDGAPLPATVGGSGVGQGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTN4</accession>
    <name>A0A7K0JTN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000552">
        <property type="protein sequence ID" value="MST33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="328" mass="34631" checksum="99BF07D5F6E76E42" modified="2021-04-07" version="1">MPVESGFAPVPDGLEVVIRTTGLTKAYPGTDFKAVDGLDLEVGAGEIFGLLGPNGAGKTTTAGMLTTRVVPTAGTATIGGVDVVRHPALVKQLIGTVSQQNTLDRALTCWENLYFHGRMFGLGGRASARAATDLLERFQLAKWAKASVYALSGGMAQRLMVARAILHRPAVLFLDEPTAGLDPQGRLSLWEILGELNRDGQTILLTTHYMEEADQLCRRVAIMDHGRILALDTPERLKATVGADTIVTVKVGGAADAAAPALRDRLEGASLARVVDGAVELHVVGTDRLVPRVVAAAEAAGIEVVDLSVKAPSLETVFINLTGKDLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR3</accession>
    <name>A0A7K0JTR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000446">
        <property type="protein sequence ID" value="MST32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1824"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="2432" mass="237661" checksum="D9C9D81CDFD48EC3" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTS1</accession>
    <name>A0A7K0JTS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_11455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000562">
        <property type="protein sequence ID" value="MST33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="203"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="540" mass="53802" checksum="0BD9E6017A618EE0" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT2</accession>
    <name>A0A7K0JTT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YihY family inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000568">
        <property type="protein sequence ID" value="MST33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="369" mass="39142" checksum="32BFA3452840F8CF" modified="2021-04-07" version="1" fragment="single">MAQVSPADRYQREHGWLGFPLAVLYKSLDDRAPRLAAMVTYYAFASLFPLVLLFVSIVGFALDGDPQLRHQLTTTVADALPGLGPELTRSITGFSGSGVALAVGIVGVLYGALGATTAAQGAFNAIYGIPRYRQPDPLRSRVRALGLLVLLGLFVVVSTGVAAVVATANGISAQLGPLAAVGGYVLAFVLNTALFSLAFQLLTALDLKLRNVLVGGVIAGAAWELLQTLGSRYIAHELSRSTALYGTFGVVVAALLWIYLQALVLMVAAEVNVVLHRHLWPRALASQWALEFEPTEADRRAYRLYLEGNRFKPFQEMEVRFAPAPQADGAASAADARPEREPIAGRSAVAPGEEAADPAAHERPAVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTT5</accession>
    <name>A0A7K0JTT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-ketoacyl-ACP synthase 3</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000563">
        <property type="protein sequence ID" value="MST33333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="231"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="330" mass="33339" checksum="01066CA971CEA1A0" modified="2021-04-07" version="1">MAADPASGAGAALVGAGYAVPAAVVGNDTIAARLGVEEAWVSRRTGTRVRHVVGPGERLEDLAAEAAARALKAAGIDAGSVDAVLVGTTTADEMSPHTAPLVAADIGAQGAAGIDVSAACVGFLSCLATGTAMIESGRARTVVVVGADVLSRYLDLDDPQSAMLFGDGAGAVVLSAVDGPTHVGPVVLRSDGQSRELIRLARDEQRIRMDGPAVYRRAVTMMTEVTTELLGRAGLAPGEVDLFVYHQANSRILRAVGAHLGLDGSRVVDLVGRFANTSSASLPIALAVSVEEGRLRAGDRVLLAAFGAGLVWGGTVVTWGRDGGTGADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU13</accession>
    <name>A0A7K0JU13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_11990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000594">
        <property type="protein sequence ID" value="MST33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="484" mass="54165" checksum="1F1EF5C8F978974B" modified="2021-04-07" version="1">MDLRVFGQRLRHLRKAAGLTLDELGTRVDRPAPYLSQLENGHREPRLTTVGQLAAALGCAPSDLLDPRPPNRRAELEVTLARIQDDPRYADLRLPHLKPSARLDDVALEHIVALFDRVRELSGAPVRPGPTRTGGARAANAAMRDEMRKRDNYFEEIERAAGEALAAVGYRGPGAISERNLTDLAAWFGFRIARVQDLPPSTRSITDQRERVIYVPQRNNATVRATRSVIGQTLGHFALGHSDPVDFDAYVRQRVEANYFAAALLAPEQAAVAMLRAAKARQDLSVEDLNEVFYISYEMAAHRLTNLITRHLDIPVHFQRCDPDGLLWKAYENDGVLLPADADGTIEGQRVCRWWSTRQAFESEDSFAMYYQYTDTVTGTYWCATHIEAEPGRGDAVTVGTTEAYARWFRGSETAHRSVSRCPDPSCCSEPPADQRSRWAGAFWPSARDHSHFVSGLPTDTVVFDPYPGVDLVDVYGFLDRHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU20</accession>
    <name>A0A7K0JU20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000597">
        <property type="protein sequence ID" value="MST33442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7160" checksum="8C1B0275C5B4C268" modified="2021-04-07" version="1" fragment="single">MPDRPYLRHPAIRGDRLAFVTDDDVWVGSIRQGGAWRLGAGPAVVRGPRFSPDGSWLAWTSRAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU21</accession>
    <name>A0A7K0JU21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000599">
        <property type="protein sequence ID" value="MST33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="1">
        <location>
            <begin position="44"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="19546" checksum="DECDA12F1316B18D" modified="2021-04-07" version="1" fragment="single">MALATSVLGAGNQVGAGSELGSWLVAQACGACSWEAAWLAALVRFDRAKQWAADGALSCADWLIGRVRLGRSTAFEKLRVAHELARRPVVAEAFAAGGITYCAVREITRAVGVDPAIDEVLVELARTATVLDVRRAVRRVLLLAEQDREPQERQATRGVRMVANGDGTTRVHAVLSDLEAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUB9</accession>
    <name>A0A7K0JUB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000629">
        <property type="protein sequence ID" value="MST33528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="124" mass="13166" checksum="76B82DD848BF9152" modified="2021-04-07" version="1">NLPMPKKLLDAGILDMVRVSDARMSGTGYGTCVLHVSPEAAAGGPLALIRTGDVVELDAAGHRLDLLVEPGELEARRAAWRAPAPPAERGWVRLYVEHVQGAERGADLDFLVGGSGDDVPRHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUC2</accession>
    <name>A0A7K0JUC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GHK86_12385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000621">
        <property type="protein sequence ID" value="MST33513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="149"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="686" mass="72924" checksum="CB728DDF95B25A66" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK0</accession>
    <name>A0A7K0JUK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="49" mass="5461" checksum="86AF6138B3C38CFC" modified="2021-04-07" version="1" fragment="single">MRCDACGAVTDPVWRWCPVCGRERQADGRHDGDERLPVTTPGSAFAVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUL5</accession>
    <name>A0A7K0JUL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000666">
        <property type="protein sequence ID" value="MST33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14929" checksum="70EF0BE9A28EF969" modified="2021-04-07" version="1">MASPVPPASARPRPARFFFPRSHRLYARFEDRAAADAAVGALAEAGFAVSGAWTFEGPSGASELDPGEITGLARLLSWWMSHNVEFLRGFGRAVREGQVVVALPAARLGTADEMAPVLRAGGGQRLVYTAHGNFVPVTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUY4</accession>
    <name>A0A7K0JUY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ORF">GHK86_13700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000716">
        <property type="protein sequence ID" value="MST33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST33766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="496" mass="52785" checksum="142E7A2CE79FDEB7" modified="2021-04-07" version="1">MREWPTVTTSEGKPREACGVFGVRASGQPVSHLTYDGLYALQHRGQESAGMAVSDGQQLVVVKDMGLVTNVFNEYKLAGLQGHLAIGHTRYSTTGASSWHNAQPVYRHAGGGSFAVGHNGNLTNTAQLADDAGMLPGTVGSDSDLLAELLARQLEGRGEDGDLVQALAEVLPTLEGAFSLVLCDRDRLIGVRDPHGFRPLSLGRLDDDGWVLASETPALDIAGATWVRDLEPGEMVVIGEDGPVSLRPWPAGAIEPRLCLFEFVYLARPDSRLYGQELHGARVRMGELLARQAPATADLVMGVPDSGIPAAEGYSYGSGIPYATGLVRNRYIGRTFITPGQSERAAGVRRKLNPLRGVIEGKRLVVVDDSIVRGTTTRAMVRMLREAGAREVHLRISSPPYRWPCYYGLDTGTRSQLIAANLSVSEIGEYVGADSLAYLTLDGLKEATGAPHAGFCDACLTGTYPTPVPLGRKAEVADGADPGPDGILAAALLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV08</accession>
    <name>A0A7K0JV08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000722">
        <property type="protein sequence ID" value="MST33781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="227" mass="24400" checksum="D41BCDC5C998A29B" modified="2021-04-07" version="1" fragment="single">MTDRSFIDQLADTWGHLSRLVHDLDPAEWDAPTECPGWDVRAHVAHVAGTEATLLGRPSPPAAAPASHVRNPIGEHNEAWVEHWRGRPTGELVAELDTVTTARLEALRAMSDAELERPGWSPVGEVPYAAFMGIRVMDCWVHEQDIRQATGRPWRLDGPAAAAAVDRLLSSLGYVVGKRVRPPEGSVVAVHLPPPVTREVVLAIRDGRAVPAADGSAPTAAVELGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB4</accession>
    <name>A0A7K0JVB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6 7" type="primary">rplM</name>
        <name evidence="7" type="ORF">GHK86_14290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000760">
        <property type="protein sequence ID" value="MST33883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="17150" checksum="DA81106480D40214" modified="2021-04-07" version="1">MRTFSPKPADIEREWFEVDADGAVLGRLASEIARVLRGKHKPIFAPNTDTGDHVIVVNAAKVQMSPGKAETKLAYRHSGYPGGLRSRTYRELLDTRPEEVIRRAVKGMLPKGPLGAQMLRKLKVYAGPTHPHQAQGPKPLEVDHSVRRLSQGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL0</accession>
    <name>A0A7K0JVL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000782">
        <property type="protein sequence ID" value="MST33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="39"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="716" mass="75584" checksum="6ED8453E1E50220F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVL5</accession>
    <name>A0A7K0JVL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_12795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000654">
        <property type="protein sequence ID" value="MST33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="12272" checksum="182CCFDFF061D4A2" modified="2021-04-07" version="1">AFEAADLDAMSGVWERSERVLCTHPGWSTLRGWSQVQASYFTLFQQPLQMQFLLTREHASVAGDVAWLSLDENLLGDQGGVTIAALNVFVRGADGDWAMVCHHASAVHASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVN5</accession>
    <name>A0A7K0JVN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent sacrificial sulfur transferase LarE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">larE</name>
        <name evidence="2" type="ORF">GHK86_12895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000664">
        <property type="protein sequence ID" value="MST33614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="271" mass="28603" checksum="AE6261A0D081194F" modified="2021-04-07" version="1">MMEARLTALRERLADLGAVIVAYSGGVDSALVAHQAAAVLGERALAVTAVSASLGPGELDACAGTAEAWGLRWRAVETDELERDAYRANGADRCWHCKSALMDQLAPLAEQLGATVVLGVNLDDLGDHRPGQRAAAERGAVFPLVDAGFTKDDVRRAARHLGLEVADKPAAACLASRVPYGTPVTLRTLDRVGRAEASLRALGFAQLRVRHYGDLARLELDADRLGEAVARRDEVVGALRAAGYRYVTLDLEGFRSGNLNGALAEVPAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW00</accession>
    <name>A0A7K0JW00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000831">
        <property type="protein sequence ID" value="MST34062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="55"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="694" mass="73858" checksum="BC2EFEA0D5C36175" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW08</accession>
    <name>A0A7K0JW08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_13510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000702">
        <property type="protein sequence ID" value="MST33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9130" checksum="63B729254A263343" modified="2021-04-07" version="1" fragment="single">MAGWLGDPRRAALLTDFDGTLAPIVVDPEAAVPLPASLPVLADLAGSLGVVAVVSGRPVRFLRQRLAGVAERLVLVGLYGLEWAEQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW79</accession>
    <name>A0A7K0JW79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000892">
        <property type="protein sequence ID" value="MST34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10437" checksum="267595EB02E7EEE9" modified="2021-04-07" version="1">MDASVVIDAVADPGVRGEAAREALAAQPASEALSAPGHFAFEVLSGLRAAANRPGHPLREADVPQALADAEAFEITMEAVSWGDVQRAWVLAVFVSRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE1</accession>
    <name>A0A7K0JWE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_16270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000922">
        <property type="protein sequence ID" value="MST34270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="418" mass="45890" checksum="17BBE0E7D1B82BB5" modified="2021-04-07" version="1">MDLTYPPEAEAFRAEIRAWLEANLPAGWGTPGFHQDPEERAAWLAAWTTTLFEGGWICAAWPEEYGGKGLSLMESVVLNEEFARAGAPLRADFFGDTLVGPTILQWGTEEQKQRFLPGIMRGETAWCQGFSEPDAGSDLASLRTTAVLDGDEWRIDGQKIWTTQAQYADYMFLLARTDAGAERHAGISYLLVPMRQPGIEVRPITQIDGSAEFNEVWFADARCPKDNVVGGVGNGWAVAMTTLGFERGTSATTGFRRFRKELDAVIDAARRRGRAADPLVRQDLARAWSTVKIMEINGFRTLSAALNGTADPGVAALGATNKMFWSEYHQWFTDRAIDLLGAEGQVLGGSADEELAPGAGRRRGRDDYAPSALQAQFFFARSETIWGGSAQIQRNIVGERLLGLPKEPRPEARAAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH8</accession>
    <name>A0A7K0JWH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000936">
        <property type="protein sequence ID" value="MST34301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="110" mass="11125" checksum="CC157216F1CB0152" modified="2021-04-07" version="1">MPAADDLEIDLDAFADAHAQGATVLDVRNPDEYEAAHVAGAVLIPLGELAARQEEIPAADPLFVICAAGGRSLQATRALLDAGYAAVSVAGGTNGWLAAGRPVVTGPTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM6</accession>
    <name>A0A7K0JWM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000961">
        <property type="protein sequence ID" value="MST34348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="114" mass="12166" checksum="D2887351B6924017" modified="2021-04-07" version="1" fragment="single">SSSRSVGMVETQYLDRHEIAMRAYGRRVVDELERDHGLPFAREGYLRLAHDDADLAAFEASAALQAEVGCDGRVLSAAQVVGLVPDLAAGACVGGLWGPTDGHVDGHRYCDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP7</accession>
    <name>A0A7K0JWP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit</fullName>
            <ecNumber evidence="14">4.1.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GHK86_16780</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.71" evidence="14"/>
    <dbReference type="EMBL" id="WJHE01000970">
        <property type="protein sequence ID" value="MST34368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="13">
        <location>
            <begin position="608"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST34368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="944" mass="102552" checksum="A8CE1D7CDD0D1429" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWP9</accession>
    <name>A0A7K0JWP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2384 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000967">
        <property type="protein sequence ID" value="MST34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024467">
        <property type="entry name" value="Xre/MbcA/ParS-like_toxin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09722">
        <property type="entry name" value="DUF2384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2384" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="122" mass="12990" checksum="A609BEBAAB63E663" modified="2021-04-07" version="1" fragment="single">MDDDQAMTAVTVEFGVHSAAEAARRAGSRGHSRTLAVRRWQQTRKVFAVPVAGIDHYPGFCFGADGRPRPVIGEVLATVGDRLAGWALAAWFVRPDPGLGGRRPVDLLDEDPAAVVEAAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ8</accession>
    <name>A0A7K0JWQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_16805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000973">
        <property type="protein sequence ID" value="MST34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="67"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="16779" checksum="27461612F2DBF460" modified="2021-04-07" version="1">MFSAADRRKRRYVLGSAEGLLDHLRSSPDPYYDPVGGFYVVAYPAGDLPEAKRVYRGVELAGMEEGFVALDQACTHLGCRVPFCRSSQWFECPCHGSRFNAVGEVRTGPAPRGLDRYAVRIEDGRLVVDTGHKVLGPPPGTDTTGQRPAGPHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWT2</accession>
    <name>A0A7K0JWT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000990">
        <property type="protein sequence ID" value="MST34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012780">
        <property type="entry name" value="CO_Mo_DH_lsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02416">
        <property type="entry name" value="CO_dehy_Mo_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="665" mass="71564" checksum="3EDFC56CC34F803F" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC1</accession>
    <name>A0A7K0JXC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001094">
        <property type="protein sequence ID" value="MST34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="8"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="337" mass="36176" checksum="C53EE4FE364ED183" modified="2021-04-07" version="1">MSRGTVLDVHSHILLPGVMGACGAAGPEMGAGPDGTPFFRSGDYVLENVRFAGSPFSDVELRLERMGQLGIDEQVVSPNPLTYFYRQPAPVAVDFNRRHNDLVAEIGRSHPALHGLACLPLQDVDAACAELERAVGQLGLLGSYIGSDVAGVPLSDRRFEPLWSEHERLGVPVVVHPAPRSAEQPADRMFGPWDLEILYGFLVDEAMAVAHLLLGGVLDRHPALAVHVPHGGGFAPYQKGRLQAGLAKRPWGRELLRRPFADQWAQLSFDTAVHRDDALAFLVATEGTDRVLLGSNFAGWDQEERSVTMVEGLGLPPAGAAAVLGGNGRRLFGLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXC6</accession>
    <name>A0A7K0JXC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001094">
        <property type="protein sequence ID" value="MST34603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="59"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="442" mass="47175" checksum="6EEDA828A57A8B48" modified="2021-04-07" version="1">MTRTLLRGGTVIDGTGAPPRPDTPVLLEEDRIVAVGAEGVAAVVAGGPAPDEVDVTGLTVMPGIIDSHCHSTLGEPASNDELFHHRDPAGAALMAAFNVRKLLLAGVTSFLDPDGLFNIGPALRDAIEAGMVEGPTMRAGGWALMTAVGGTAGRMIPESGTAGYAEVVRDRDEMITATRRQIKQGADVIKIHVTGSVPTKRGELQVWTLDELRTVCDTAHDLGVRVVAHCRGAGATRDAARAGVDIIFHASYMDEAALEAIHEAGSSLCPVFTFLANLAEHGAKAGSTSAVQDVFRREMEDTGRMMRRAYDEGVPLLAGSESGFSLTPYGHWHYREMEIFVEHLGLTPLEALTTGTKNGAIALDQVGEVGTIEAGLRADVLVLDGDPSRDVSLLGDRRRFRHLWCRGKEVDLSGPWPERRPLPGEKLATWSAVPLTWDLVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXG4</accession>
    <name>A0A7K0JXG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ORF">GHK86_18145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001118">
        <property type="protein sequence ID" value="MST34636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST34636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="26753" checksum="63972284A33929C4" modified="2021-04-07" version="1">MGSHLLGAINVPIGEHLTAGPLNIDTMYTTTIAVIVVIGLGLWARSKMTSGEPGKVQLVWESVAGFIGDQAEGALGPNAREVVPWGITIFMLVLVADWIEILPGIFHGKDYLPSPSADVNFCYALGITVWLVTNFAGIRARAKRTGSWGKGYVQWLKMFFEPLHFVEHITRWLTLALRLFGNIFAGSIMIALLLAFPVYFFPATIGFTVVWKLFDMFIGVVQAFIFALLTILYWQFNVETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXI9</accession>
    <name>A0A7K0JXI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000917">
        <property type="protein sequence ID" value="MST34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="98" mass="10792" checksum="EDD90851F5B428AC" modified="2021-04-07" version="1">MVELLAHVSSGQLAGHFTEGADMTFGIPIGTLAVAVLLAFFQRKPLPDRRRQPMFPLSGIPQRSYDLAIVNALHKRRRDELVADRDARTAGAERPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXL9</accession>
    <name>A0A7K0JXL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DoxX family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001117">
        <property type="protein sequence ID" value="MST34632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="88" mass="9198" checksum="08F49034F9A48E55" modified="2021-04-07" version="1" fragment="single">MTLTRALARPMLAAPFVATGIDTLRDPGPRVEQAERVAPGLAAKLGLPTDAALWVRINAGVHVGAGTLLAFGKFRRLSSLLLLASLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXM4</accession>
    <name>A0A7K0JXM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding S4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_18480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001162">
        <property type="protein sequence ID" value="MST34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="14579" checksum="50619002EA7AB40F" modified="2021-04-07" version="1">MGGMVDGDETRVDRWLWAVRVYKTRGSATDACRAGHVRLRGRAVKPAQPLRPGDVVEVRVDGWERRLEVVRTIDKRVGAAVAAECLVDHSPPRPPRELVPPPLFVRVDAPGRPTKRDRRALDRFRERNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN5</accession>
    <name>A0A7K0JXN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_18550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001172">
        <property type="protein sequence ID" value="MST34716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="304" mass="31738" checksum="0336C57725C59024" modified="2021-04-07" version="1" fragment="single">MAPQREWFEKDYYQVLGVPSTATAKEIGKKYRELAKKYHPDAHPGSEERFKEVSAAYDVLGDESRRKEYDEVRRAAAMGNPFAGAGPGAGPGPGGGSFRVDDLSDLIGNIFTRNSRRGAAPSTGGPQRGADLEASLNLAFLEAVHGVTTTVNVTSDAPCHTCGGSGAAPGTRPATCANCGGAGVVNDNQGLFSFSRACPVCGGAGRIIEKPCPTCLGSGTEVRARQVKVRVPAGVEDGQRIRLKNRGGAGRNGGPAGDLYVSVHVSPHPVFGRRGRDLLVTVPVTYPEAVLGAEISVPTLDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXV8</accession>
    <name>A0A7K0JXV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase IV</fullName>
            <shortName evidence="13">Pol IV</shortName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">dinB</name>
        <name evidence="16" type="ORF">GHK86_18955</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="WJHE01001218">
        <property type="protein sequence ID" value="MST34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 13" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="15">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="13">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MST34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="427" mass="45489" checksum="1A40A69D0762CC2D" modified="2021-04-07" version="1">MLHVDMDAFYASVEVHDDPSLAGRALIVGGDGPRGVVASCSYEARRYGVRSAMPSSQARRLCPHAVFRPGRYERYEEVSRAIHAVFHRYTPLVEGIALDEAFLDVTGAERLFGPGPAIAGRLRDEVCRETGLRCSVGVAPSKFLAKLASEAAKPRAGRDGVRPGPGVVVVAPGEELAFLRPLPVEALWGVGPATAARLRGVGITTVGRLGDTPLAVLESVAGRAHGRHLHDLARAVDPRPVEPDRATKSIGHEETYVTDRYDRDGLHVEIVRMADAVAARLRRAGLAARTVQLKLRSGDFTTRTRARTVARPLRDGPGIAAVAGELFEREELDGGVRLLGVSVSSLEAAADAEQLELGFGDDDTPRREAAAGAVDAIRARFGEQAVGPGSLVRDGTLRVGRPHDNRWAPVDTASPPALPSSRPGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXW3</accession>
    <name>A0A7K0JXW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000963">
        <property type="protein sequence ID" value="MST34359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="230" mass="23636" checksum="298F67A5765EE219" modified="2021-04-07" version="1">AAIDAGYAFDPCHHGHEYHAPEELADLIGRAHAAGLQTGTHAQGDRAIRVALDAIELAQASAPRPDARHRIEHCGLPGAANIARMAALGAVAVNQPQHHYLYGEAVAAAVGPAGRNYNPLGSLRRAGVAIALSSDAPVAPPDPLRAISTAVTRRTVSGAVLGDPGEALTVEQALAAHTIGAARAMRREAAIGSIEPGKLADLVVLDRNPLRCDPDELPGLAVSRLPAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY02</accession>
    <name>A0A7K0JY02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000980">
        <property type="protein sequence ID" value="MST34394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="346"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="690" mass="73423" checksum="80D559E59C048E4B" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY19</accession>
    <name>A0A7K0JY19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001247">
        <property type="protein sequence ID" value="MST34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="12622" checksum="E4E42510227BF5A3" modified="2021-04-07" version="1">MSLTAAATMATLERTGPRRITDLAALEGVTQPSMTALVGTLERSGFVERRRAATDQRVVLVSLTPAGAGYLRAVRRSGAEGFARLIDKLPPDDLGAVARAAPALAAMVDRHDRDRELAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYD8</accession>
    <name>A0A7K0JYD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001331">
        <property type="protein sequence ID" value="MST34966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="112" mass="11881" checksum="620CC704D4DD85E3" modified="2021-04-07" version="1" fragment="single">MIVALARTSPLIWYATRGTGFVALALLTVTVVLGVAQVARWAPAGSPRFVVNALHRNASLLAVAFVGVHVATSVLDTFVHLRVLDAFVPFAATYRPFWLGLGAVALDLVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYG5</accession>
    <name>A0A7K0JYG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endopeptidase La</fullName>
            <ecNumber evidence="8">3.4.21.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lon</name>
        <name evidence="8" type="ORF">GHK86_19890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="8"/>
    <dbReference type="EMBL" id="WJHE01001337">
        <property type="protein sequence ID" value="MST34977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="6">
        <location>
            <begin position="587"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="705" mass="75616" checksum="8CA0646AE3CF428B" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYH9</accession>
    <name>A0A7K0JYH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_20095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001364">
        <property type="protein sequence ID" value="MST35018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="16104" checksum="B26E04D88A9FBF9F" modified="2021-04-07" version="1" fragment="single">LNVGQVYTTLARLSRDGLVEPADDGEEQQRTYRITPAGRQALDRWYAEPVAPGAPPRNELAIKLALAVHHPELDLAAIIQAQRTATMRTLQEYTRAREAAADDLSWQLVADALLFAAEAELRWLDHAEAHLARRRPARPTGPAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYN8</accession>
    <name>A0A7K0JYN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001127">
        <property type="protein sequence ID" value="MST34654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="163" mass="16560" checksum="1F1726B5E7E53F1F" modified="2021-04-07" version="1" fragment="single">MTTGTPDTAAAEARLEELAPGYLAKVRAAAAALAVDAHGGGSVAVEVAAVREAAEFDLDVPTLSMNPVGSYVKEAVKRATSWYLRYLTVQVAGFARSVTSMGEALATQLERLDRVDADQAGELEALRERVAELEAAAAATAAPAGRSANAGTASEGSVGAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX4</accession>
    <name>A0A7K0JYX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001472">
        <property type="protein sequence ID" value="MST35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="1">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="16546" checksum="C5863266FD22D23D" modified="2021-04-07" version="1" fragment="single">GVPSDRGPGEPPRAMALSSDGNGYWCALDPRAGTALVVAESALNVACVGARPVAVVNCLNFGNPEHPEVMWQLSEAIDGMGEACRALGLPVVGGNVSLYNESRGHDIDPTPVVATLGLVDELHRRPPGVRLAAGDRVLLVQPPGTRPSLGGSQWAVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ32</accession>
    <name>A0A7K0JZ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_19060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001230">
        <property type="protein sequence ID" value="MST34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="16132" checksum="53D38B13A327E079" modified="2021-04-07" version="1">ARDGGHPVVWTTVAYRPGGHEAPLFRAKVPGLTAFEAGSPLGAWPAGHGPEPQDWVVTKHFASAFFGTDLASGLVARGVDTVVVAGFSTSGCVRASALDALQHGFRPIVVADAVADRDPGPHDANLFDLDAKYADVVELAEAVGALRSRPRPEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ45</accession>
    <name>A0A7K0JZ45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <ecNumber evidence="2">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_21230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001546">
        <property type="protein sequence ID" value="MST35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRAI" evidence="4">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="211" mass="22078" checksum="31EB3A718F9C08D1" modified="2021-04-07" version="1" fragment="single">MIVKICGTTNEDDALLSVALGADLIGFIFAPSPRQIAPQVAADIVKRLPPEIVAVGVFRDEAPKRVVDIALRSGMRAVQLHGHETPEETRWIRERVPLVIKVFAAGDPKVARALDYGADIVMLDGPRPGSGEGWDRSYADGVPTGPRLMIAGGLDATNVAGVIARTRCWGVDAASGVEKAPGVKDPVRLRAFIAAAKAAAPDGGDGAGGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ78</accession>
    <name>A0A7K0JZ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001517">
        <property type="protein sequence ID" value="MST35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="66" mass="7188" checksum="6465173F142EF151" modified="2021-04-07" version="1" fragment="single">MPAGWADDDARVIEGPPPPLHAPAELEAVLREHHGALLRTARRLCHDADAGEDLLADVYARAWPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF0</accession>
    <name>A0A7K0JZF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001576">
        <property type="protein sequence ID" value="MST35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="15523" checksum="03A79168659E9AEC" modified="2021-04-07" version="1">ARAEAAARAATVAGLLVAASLLGLALGSPAEPSGPRVHLVARRVGGSPLLATRRGLTLYWFARDSPTRSHCSGTCAAIWPPVLGDPVATRGITGTFGTIRRSGGRLQATYDGHPLYTFSGDSPGTARGNGLVLNGGRWYEMRVNGQNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG6</accession>
    <name>A0A7K0JZG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">leuD</name>
        <name evidence="15" type="ORF">GHK86_21865</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01001670">
        <property type="protein sequence ID" value="MST35365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="14">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST35365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="190" mass="20770" checksum="D1E1708E8B5AF45F" modified="2021-04-07" version="1" fragment="single">MQPVRAVTGTAVPLDRSDVDTDQIIPSDWLKRVERTGFGLGLFAEWRDDRDFVLNRPEHAGATILVAGPNFGVGSSREHAVWALQDYGFQAVVSPRFGDIFRNNSTKAGLVPAQVDADFGRRLLDVVGADPDLEVTVDVERLVVAVPAAGLEGAFVLDPFTQHRLLEGLDDVGLTLRHADAIDAFEQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZK0</accession>
    <name>A0A7K0JZK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001632">
        <property type="protein sequence ID" value="MST35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="313" mass="32316" checksum="AB41BAC1064CFCA2" modified="2021-04-07" version="1" fragment="single">EALGMALPGSASAPAVDPRRDQLAYESGQAVLALLDAGIRARDILTKEAFENAIAVVMALGGSTNAVLHLLAIAHEARVELTLDDFDRVGRRTPHIADTKPHGRYHMVDLDRIGGVPVVMRELLEAGLLHGHCLTVTGRSIADNLAASPPPGPDGSVVHPRSRPIHADGGIAILRGSLAPEGAVVKVAGIDTDRFEGTARVFDGEDGAMEAILAGSIQPGTVLVIRYEGPKGGPGMREMLAVTGAMKGAGRGGDCALLTDGRFSGGTHGFCIGHVAPEAVDGGPIAFVADGDRIVIDVPSRTIELDVPGDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZQ6</accession>
    <name>A0A7K0JZQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Circadian clock protein KaiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kaiC</name>
        <name evidence="3" type="ORF">GHK86_20280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001388">
        <property type="protein sequence ID" value="MST35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="246"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="51219" checksum="EDB9E43426E8C729" modified="2021-04-07" version="1">MPQGRIEHCRTGIVGLDEVTAGGLPRGRTTLLSGGPGCGKTLLATEFLVRGAELGEPGLFVPFEETAEEVCANGASLGWDLPALVEDGSLLIDHVAVERDQIEQTGDYSLDGLLVRLGFAIDRIGAKRVVLDTLEVLFSALDDTAVLRAELRRLFGWLKERGVTAIVTAERSGQGITRYGLEEYVSDCVIVLDHRVTDELAVRRMRIVKFRGSRHSSSELPFLIAPGGLSVVPLSRFDLSYPTSDEIVSSGVPDLDAMLGRKGWYRGSTVIISGTSGTGKTTFAAQFAAAACERGERCLFMAHEEGERQIIRNMASVGIDLAAPSAAGILRVRAVRPTQTGLEDHLATLHREVEMFAPDVVVIDPVTDFHSLGSSREIRSMLMRMLDFLKQRQVTAVLTSLVPEGHHEDTVISSLIDSWVQLRAERTDHGRGRVLYVLKCRGMPHSQEVRPYDITDSGIVIREAAEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMF7</accession>
    <name>A0A7K0JMF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_00140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000005">
        <property type="protein sequence ID" value="MST31140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046069">
        <property type="entry name" value="DUF6027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19492">
        <property type="entry name" value="DUF6027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="127" mass="13835" checksum="F5EC01F8D5394958" modified="2021-04-07" version="1">MEVMAQRRAVQLVAWDGPWPDDDPDANFKADVALYAHVDPMTTVENLAAALDMPVGAIVWYVLAKWASAGSGALLELGPSMIHRLWEPVEAAEAAGTDAARLAAYEQLRQMLSWLRLPLTDPDSAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMJ7</accession>
    <name>A0A7K0JMJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GHK86_00170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000006">
        <property type="protein sequence ID" value="MST31145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="806"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="924" mass="96535" checksum="A717313C9D4CD6FE" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMY4</accession>
    <name>A0A7K0JMY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000022">
        <property type="protein sequence ID" value="MST31237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="283" mass="30602" checksum="854BD872899A24EB" modified="2021-04-07" version="1">MTFLITGATGNVGGQLVTQLIDARHHVRAYVRNPDKARQQLPETAEIAIGDLDDTAALNKAAEGVDAIFFMQAAPIPTQAQNVVDAAKAAGVRRIVVLSSIGTALHPMCIIGAAINARDDVLRASGLDITYLKPNTLSSNALWWKTSIATEGKVYDPTDPGLTPPIDPYDIARVAATVLTQPGHEGHSYILNGPEALSAREQVEILADVLGRQIEFVAVTPEQYAEVNISRGTPEPQARALQDLQELFRAGRSGILGEDVQNLTGIAPRTFRHWCEQHRTEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG5</accession>
    <name>A0A7K0JNG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000075">
        <property type="protein sequence ID" value="MST31478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="129"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="571" mass="61553" checksum="BCC847FA0F1B1734" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNG8</accession>
    <name>A0A7K0JNG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L,D-transpeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_01945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000082">
        <property type="protein sequence ID" value="MST31495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029744270" evidence="4">
        <location>
            <begin position="42"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="283" mass="29144" checksum="6F28387FC481E586" modified="2021-04-07" version="1">MTASGPRGPRGLRWLGAAASAVALSLAIAACGPSTQQSATAPTTTTSAAGTTTPSATTTPTTPATTVPPATAAPTTSPTTAVRAASLLQRGDTGAAVRSLQQRLTALGYWLGTPNGIFGDSTQQAVYALQKVAGLTPDGVVGPLTAAALARGAVPTPRSTSGTLLEVDLHHDLVLFVRRGRLTATLNTSTGGGYTYTDNGVTAVAETPTGHFRIYRQVDGMVTDSLGQLWRPKYFTGGFALHGDSSVPPEPVSHGCVRVSNEAIDWIWADDLAPLTTEIWVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL2</accession>
    <name>A0A7K0JNL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000067">
        <property type="protein sequence ID" value="MST31441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="241" mass="24207" checksum="EED876F6D5F81CC8" modified="2021-04-07" version="1">TVPAAASALPTYVVQPGDSFWGIAQEDGLTVGRLAAANGLAPSDVLLPGEVLRIPPQGSGGSSTGSVPSSPLAPVVVTVAAVGPRAGGAACPRVAGNAYGVLPAVLAASPERQALLPLFRQWAAVYGVSPALVEAIAWQESGWQAGVVSPAGAVGIGQLLPATVRFIEANLVGATLDPWSANDNIRMMTAFVAYLAAREGGDPCATIAAYYEGPGALASVGLLPVSVPYIADVEALVPQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNL4</accession>
    <name>A0A7K0JNL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000092">
        <property type="protein sequence ID" value="MST31538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="203" mass="21808" checksum="96060EC311D0F8C0" modified="2021-04-07" version="1">MAETPGSSLQRLAAATGGVVTPANLLDVVALVGAWWAAPRLGTWKGYAVGAPSYFADLADGIIARRTGTVTRVGEIMDHVVGDKPKIFWGAWHIWRLRLADRPLIATVAVYNVTNAVVTGYDLLRNAEPGVFPDRRAKWAMMTSATGMGIQVAATNAERTHPRLARALHACGAISSYGGVALFGIPTTVGYWQTARNGPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNV2</accession>
    <name>A0A7K0JNV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000102">
        <property type="protein sequence ID" value="MST31593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="191" mass="20688" checksum="1C8A87299ADED5EA" modified="2021-04-07" version="1">MLSAQSVGRDFQLRDRNRPHPAGDGSLSQNAIKPSLLGNPMVESETIARRGTPIGAGYSLSLYPPARTEPTQVFSLTQTITFLTTQRAASSWFHQFAPSHVTPQVRVGSTLENVNEARLPAPHLGQQTMVTKQSLPGTDLPTTIQFIVRDGTTVASLAFIGGIHLSPRALTDYVKTALDQLATRCTSTVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNZ6</accession>
    <name>A0A7K0JNZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000111">
        <property type="protein sequence ID" value="MST31665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15869" checksum="912311478EEC137E" modified="2021-04-07" version="1">MDPARNTVVAVIEIDASLAGYRRLWRWAGQFEERRWAVEGVRGLGRHLAQWLVARGEQVDDVASTATARVRELSRGGRRKNDVWVEPAHGSPSSWWPPTTAWWVGTTGLLGSPPPSAPPAPTAPPPAAGPASPGWPRCTPSPPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP17</accession>
    <name>A0A7K0JP17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="154" mass="16286" checksum="449834677A3E123C" modified="2021-04-07" version="1">MSGKDSRSALSTVLAGAYADLARLEALLPALLEHAGRRPGTFGHAVEDDDAEALADAEQWLDDLHVATEALVGVLARGPGVAGAMAARPLVPATTPRTLCDRCGRPQRSGERFRQRLCVPCYGRMARWRAAKGNAGKGVSEWMAYDGGGSGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP27</accession>
    <name>A0A7K0JP27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_01050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000037">
        <property type="protein sequence ID" value="MST31319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="31934" checksum="7C8857ECFC548B39" modified="2021-04-07" version="1">FRRLAGKTQVFVFPRDHQRTRLTHALEVAQVATAVARAVGLNVALTEAIALGHDCGHGPGGHASEDAFAPYLPGGYDHAVWGADVVLAPLNLCAETLDGVRHHSWSLPSPRTPEGLVVSWADRCAYCAHDLEDATSAGIVGADPLPDEVTAVVGHTRSAQLRAFVGALVACITETGRVGMRPEPAAALAALRRFNYERIYTQPAAAAQGRAVVAVLRGLVDYFAEDPGRLPGGPPEPDQEQDPVRRAVTYVAGMTDRFAFETAVARLGWDRRRLPRGIDVGSGPEPAAPPGAAARLSRDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP35</accession>
    <name>A0A7K0JP35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_02710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000109">
        <property type="protein sequence ID" value="MST31641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="282" mass="29995" checksum="91FF49CFFBE50101" modified="2021-04-07" version="1">MSSLQPDPTVAVGAPVQISGAVGWRERHGRRVAVLVAQVVLLAAAIACWQLLAGRVISVLFVSKPTLVWHQLVTWADSGSLWSNSWITIKEILLGYALGAVAGVALGFALSLLRFASSVLDPFIMALYAIPKVALAPLFIVWFGIGLQMKVILAATTVFFLVFINTTAGIKQVDTALVDAVRLMGGSRRQLITKVILPASMSGVLTGLRVAIPYALIGAVIGELVASNRGLGYLINESASTLNTAGVFAALVTLTVIAAILNALVNVLGRWTDRWRPLDDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP48</accession>
    <name>A0A7K0JP48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000117">
        <property type="protein sequence ID" value="MST31693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="176" mass="18818" checksum="7366F4299C51DCC1" modified="2021-04-07" version="1">MDEGTRRQFLAALRTDDAFRAAVRREVVGNELLALVASAADPIVEDLRKTVDTLVDVVAEHRRELDLLAATPPARGLDDATRRDLATLAVGLGEVRARVAALAETTARHTEQLAALAEASAPILPLVQNGFVAIRDALTGLVSGMQSTQRELAELRETGIGVVDLRDAPAGERRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPA2</accession>
    <name>A0A7K0JPA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoD</name>
        <name evidence="4" type="ORF">GHK86_03125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000124">
        <property type="protein sequence ID" value="MST31721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 2" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="3">
        <location>
            <begin position="141"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="411" mass="46300" checksum="13A143808FF7A2B1" modified="2021-04-07" version="1">MGGVLRLPEGVGIDPADLDIDVPTDETMILNLGPSHPSTHGVLRIMVELEGETVLRSKPVIGYLHTGMEKTGEELMYHQGSTNVTRMDYLSPFFNELTFSLTVEKLLGLELPPRATWIRMLMSELNRISSHMLWLATNGSDIGAINMLVYGWREREVLLQWFEKVTGLRMNHNYIRPGGVAADLPDGWRDDVLTICEMMSRRMDEYDRLLTGQPILQKRLQGVGPLTAEEAISLGLTGPLLRSTGVPRDLRRDEPYLAYDEVDFDVIVGEVGDCWDRYAIRFNEIRESIRICRQICERMPAGDYRAQDKKVTPPPRNRIDESMEALIHHFKLYTEGFRVPPGEAYVPVETPRGEGGCYIVSDGTSRPYRMHMRAASFANLQGLPRMARGALIADTIAIVSTIDPVLGDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPJ9</accession>
    <name>A0A7K0JPJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000154">
        <property type="protein sequence ID" value="MST31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="6339" checksum="DCF823BCC1B769C1" modified="2021-04-07" version="1">MTGTRPAGDVEPPPRDEDAPREPVGDPTRALWRRSETKPDGRRLTRYEQAGGGPERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ0</accession>
    <name>A0A7K0JPZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ORF">GHK86_04675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000197">
        <property type="protein sequence ID" value="MST32020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="4"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="613" mass="67379" checksum="E382590C890298DB" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPZ2</accession>
    <name>A0A7K0JPZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000188">
        <property type="protein sequence ID" value="MST31981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="20005" checksum="34221E63E2A56487" modified="2021-04-07" version="1">MGQGKDVAATAGGALGRVGRGVLVGAAAVGLAVGGAGVAAAASSPAHPAGAVQARHPLDARVGAEGPVIHGEWTVEHGGAFSTFVEQIGTAGAPASSSSTSTSTSTSITVTSADNFQQTYTITSSTRVSPRGTTIKQGDTLRVYATVPAPSTTGGSTTGGSTTGGSTTGSSTAADTAVSIIDVTAARAADGGHDHHDGRPGRGSHTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ35</accession>
    <name>A0A7K0JQ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_04880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000202">
        <property type="protein sequence ID" value="MST32060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="414" mass="42436" checksum="2980799A9D31705D" modified="2021-04-07" version="1">MPLLRNASYLYVGTMITSLLGFAFWNVAARAFTPSDVGIASALIAGSQLVADVAILGLGTLMIAKLAEGRAGAGELLLTGTVVTVVTGLLGGVIAEVVLTTSGSRLADGLHGWAMRAVFASLASLTTAASLWDNASVGLLRGRIQLARNSVFAAAKLAVLALLVTRLPALQPGGGGLLVAWEVGMVVSLVPAARGLWAATPIRGSRVRVGSLLRDRRLVFQHHWLNLSVHAPYMLLPMIVATVVSPRANAGFYTAELLVGFVAIIPSFVSTTLFALKPGDRAALRRELRAGVGVTLAVAVAAAVGFGLAGPIALELFSAKYLFAGLAIRLLGLTVFPAGIKAFYVAVARVHGRMGRAAVRTSIAAAGEVTAAAFGGASAGLSGAVAALVGAYCIEMLILGPTVLRASRPEARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ56</accession>
    <name>A0A7K0JQ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WhiB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_04710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000198">
        <property type="protein sequence ID" value="MST32027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9419" checksum="82F812ED11133FC9" modified="2021-04-07" version="1">MADTRRSWRSAAACRGLPTAMFFPDPHRPEADGAADARAVCNTCPVRDACAEAGAAEPDGIWGGLSPQERRERRAGRHGAPMWRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ95</accession>
    <name>A0A7K0JQ95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_05215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041113">
        <property type="entry name" value="Heliorhodopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18761">
        <property type="entry name" value="Heliorhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="266" mass="29068" checksum="96404F7193BB0C8C" modified="2021-04-07" version="1">MSAPTRPLSRTGPPSGGREMLVARLRPYNLAAGLLHLAQAIAVVVLANQFALPVRARYMTGPPGPQVGTDTVTLFSVRFAWAVAAFFGLSALAHLLVVGPAWNRYRRLVSQGRNPYRWLEYSLSASIMIVLIAMLVGIDDVAALIALVGVNASMIGFGWMQERYETPGAGMQPFWIGCMAGAIPWIAIGVYLIGPGADLHPPGFVYAIFFSLFGLFNCFAVNQWLQYKQVGRWKEYLVGERAYVTLSLVAKSLLAWQIFASTLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQB1</accession>
    <name>A0A7K0JQB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_03325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000129">
        <property type="protein sequence ID" value="MST31759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="127"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="277" mass="28190" checksum="3A4DCFA25F02ADF3" modified="2021-04-07" version="1">MLSVQLGSALSVPLASRVGPAGIAWLRLTAGAAIFLAVARPSRRSLSRRDIPALVALGVTTGLETVAFLAAIQRIPLGTAVAVEFLGPLTVAATRTHQRRALAWPALALGGVVLLTQPWHGRSNPTGLGLAVLAAMGWAAYILLTQHVGDRFDGIGALSITVPIAAATAAVIGIPQAAGHLTLGLVPAAIGLGLLLPVLPYTFEMLALRHIAPNAFGTLMALEPAIGVILGLLVLGQQPTGLQLLGVLLVVVAGAAAQGHGRRQRPPVLAAAHRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQC9</accession>
    <name>A0A7K0JQC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000218">
        <property type="protein sequence ID" value="MST32123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029507073" evidence="2">
        <location>
            <begin position="29"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4397" evidence="3">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="273" mass="26404" checksum="28E6A3DA9EE1655A" modified="2021-04-07" version="1">MARPLRSLAAGLALGAAALTVAATPAGATGTGTVTVIHGVPGATVDVCANGSAAISDFTYKSQKTLSLPAGTYDLGIVPTGKPCTASNYLATASAPLAAGENVSVVAYLTTSGKPTLGLYANDLSAVPSGQGRLVLSHNANAPTVKVVAGTSTLVPSLAPGSQAAVVVPAQSYSGVNVEVASSGAAAISNATVPVTADADTIVYVVGDSSAGYSTVAQSIPLTPSASVPGSVVTGNSPVGTTHDLPLAGLAGALAVAGALFGVSLRALRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM0</accession>
    <name>A0A7K0JQM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="9">2.8.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GHK86_05585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9"/>
    <dbReference type="EMBL" id="WJHE01000240">
        <property type="protein sequence ID" value="MST32197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="130"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="391"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MST32197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="469" mass="50459" checksum="318526B3408CF618" modified="2021-04-07" version="1" fragment="single">MNEHDSQRLAGILEADGMVPAGDLADADVVVLNTCCIRENADNKLYGALGHLKAAKAERPGLQIAVGGCLAQKDRDHIRRRAPWVDAVWGTHNVGRAGELLARAAAEGPLTEIVESGDEDTFASALPVKPDQGWAAWVTIQVGCDNHCAFCIVPAVRGPEASRPFGQIVEEVTRLAEEGVVEVTLLGQNVNSYGRDLTTALRTDPEWGKGAAITGPAWAGDERPRARPLFADLLRAVSTVPGIRRVRYTSPHPKDLRPETIEAMASEAAVCEHLHLPLQSGSDRVLAAMHRGYTAARYLERLAAARAAIPDLAVTTDIIVGFPGETEDDFSATLEVAAEAGYDSAYTFIYSPRPGTEAAARPEDFIAPEVAAERFERLRVVVERSALARHEARVGRVEEVLVEGPSKRDPAMTSGRTRQGKLVHLPATGLRPGTFADARIVRGAPHFLVGELVAVTAEPRHRTRIPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM7</accession>
    <name>A0A7K0JQM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MogA/MoaB family molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_05870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000256">
        <property type="protein sequence ID" value="MST32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="155" mass="15723" checksum="2BA3DAE8BA00F245" modified="2021-04-07" version="1">HQAKVVTVSDGVVAGTREDRSGAALVAALGEAGFEVVERSVVADGVASVAGELARATASFTGLVVTTGGTGFSPRDHTPEGTREIIERDAPGLAEAMRLVSPLGRLSRGIAGIRGQAVVLNTPGSPTGAVECFQAVADVLPHALELLADEPTHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQU3</accession>
    <name>A0A7K0JQU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000265">
        <property type="protein sequence ID" value="MST32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-3" evidence="2">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="2">
        <location>
            <begin position="322"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="380" mass="40021" checksum="90E381D79C67C48F" modified="2021-04-07" version="1">GLAEACHDPAALRAAYAQVIRRYHLSVVDFDVEGTAVSDTAATERRARALASLQSAARAAHRRLAVWLTVPVARAGWTPAVTDLVRTTLRAGVDLAGVNVMAMDFGPPIADEEAAVQQAVGAAAGQLARVYRQVGIRLDASQVWARLGVTVMIGQNDSAGEAFTTADARRLAAFAARKHLARVSAWSLNRDRQCGSEFPVVGAHSDTCSGVAQSTLQFSHILAGLRGSAARSAGPTPAPYVPSAVEDPATSPFPIWNATAAYAAGYKVVREGYIYQAKWYNQGSDPAAAQTQNPWQTPWELIGPVLPGQHAPKPPTLAAGTYPAWSPTVAYQAGAEVLRDGLPYVAKWYTKGDDPLAAADGSVSSPWRAAYTLPGEPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR18</accession>
    <name>A0A7K0JR18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_06525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000280">
        <property type="protein sequence ID" value="MST32375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="313" mass="33975" checksum="184EFB5A680A610C" modified="2021-04-07" version="1">MTQEAATAVADVPLRPSGRKRIRGAPVVFLAPFGLLFSVFFLIPIGYAVYESLFQIHVSGLGLGPATTVFAGFANYGRALSNGAFLAGIERVVLFGIVQIPVMLVLATLLAVLLDSVTARFKRFFRLAYFLPYGIPGVIAAILWSFLYLPGLSPIVGIFKTVGFGSVNFLGVHSVLWSIANIVTWEYTGYNMLIIYAGLQAIPRELYEAARIDGAGEWRIATRVKLPMVFSSIVLTAVFSIIGTLQLFSEPQVLRSVTTNISSTFTPNLDAYNQAFTFNNPNEAAAIAVVLAVGTFILSFGFLRLTSRRGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR24</accession>
    <name>A0A7K0JR24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpS</name>
        <name evidence="10" type="ORF">GHK86_06650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="350" mass="38003" checksum="1B4650BAAFB5E2D3" modified="2021-04-07" version="1">MQRAASGRTSSRQGECHRRSDNSRRDSVVSSITSSASEVAAVARTVALETRIREDPASFRVLSGDRPTGPLHVGHYFGTLANRVRLQEMGVEVFVLVADYQALTDRDAPRALAEDVLGQVADYLAVGIDPARATIFAHSQVEALNQLLLPFLSLVSVADLARNPTVKGESTAGGAGPVSALMFTYPVHQAADILFCHANVVPVGKDQLPHLELTRHIARRFNDRYAAGEPYFPRPEGLLGAAPLLLGTDGTKMSKSRGNAIALAATEDETARLLRAAKTDSRRAITYDPRQRPEISSLLLLAALCRRPEPFVDRLGHELLQGGGATVTHGFRHHLGRLVHDVRTLMRTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR65</accession>
    <name>A0A7K0JR65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsR</name>
        <name evidence="6" type="ORF">GHK86_06765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="70" mass="8341" checksum="48030920DFF0572C" modified="2021-04-07" version="1" fragment="single">MARNNDRDRGKRAVKDNRPRGKKKVCIFCKEHAVWVDYKDVNLLRRFMSDRGKIRARRVTGNCAQHQRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR72</accession>
    <name>A0A7K0JR72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">treS</name>
        <name evidence="9" type="ORF">GHK86_06895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000294">
        <property type="protein sequence ID" value="MST32446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="8">
        <location>
            <begin position="56"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST32446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="594" mass="68264" checksum="C04D31CE477F8E08" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRK9</accession>
    <name>A0A7K0JRK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000333">
        <property type="protein sequence ID" value="MST32571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="216" mass="23372" checksum="444B5B98D75A38DF" modified="2021-04-07" version="1">MPAAVSRDDDSRASGVLRRSGGLLVPSDGPPPTRAEVRRTRLWLLLFLLTPVCLAVAVAFALGIAGPPEPVVHPVSVPPGYRAISDAYYGYAVPTSYRQNPAWTDANGDYFYGTPAHGWVAETLLVRHHPPTARTAPPTTFRFDGEVRSAPFRLSGGHPIRVARTSFAWAVEVTRPGGWHALAVDTWLQDSSTQMWLLVKAPPAVTRTVIASLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRL5</accession>
    <name>A0A7K0JRL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_07450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000329">
        <property type="protein sequence ID" value="MST32557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15368" checksum="9FA1656D1E6B4375" modified="2021-04-07" version="1" fragment="single">MTDGGQPPEDGPGVLQRPVGSRHPGRGDEAPGFRLDGTGGRSYALEDYRGEPVVLVFYPADHSPVCTQQLRSYSEDLGLFEELGAAVLCLSPQDVATHEDFSRLHDLKVPLLADTGKAVGRAYDVLGPLGFYRRSIFVVGPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRS4</accession>
    <name>A0A7K0JRS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_07920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000351">
        <property type="protein sequence ID" value="MST32646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9172" checksum="38AA11376FFFD593" modified="2021-04-07" version="1">MVNVWESVDAAHEARQFCDIYDLDSTVLLDESGAFIGRTEVRGVPFNLVVGEDGVVLGAGLTHPEELTAFLEARGLIAPEAQDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRU8</accession>
    <name>A0A7K0JRU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_07995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000354">
        <property type="protein sequence ID" value="MST32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="248" mass="27249" checksum="B03211EECA33BBC7" modified="2021-04-07" version="1">LLDVGCGWGAMLEHAAVHHQARGVGVTLSENQRAWAAKRMAEVGADMQVRVQDYRQVGDGPFDAISSVGMSEHVGQANLPTYFAKLFELLRPGGRLLNHAISALPAGRRRGEWPTPVQLPAALRARLSRPGEAGFAPDSFISRYIFPDGELIEVGAVVSAMQRAGFEVRHVESLREHYGLTLRRWLANLEQHWAQAVAEVGERRCRAWRLYLAGSAWSFETGRIAVHQVLGVKPAGGRSGMPLRPQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JS45</accession>
    <name>A0A7K0JS45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <ecNumber evidence="4">4.1.3.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_06600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000284">
        <property type="protein sequence ID" value="MST32389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST32389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="297" mass="32510" checksum="7851BF98F8363F99" modified="2021-04-07" version="1" fragment="single">MANLPGVSALFDPDAWEEVPGFELTDVTYHRARDQGTVRVALDRPEVRNAFRPRTVDELHRVLDHARQSPDVGCVLLTGNGPSPRDGGWAFCSGGDQRIRGRDGYLYADGETAAEVDPARTGRLHILEVQRLIRFMPKVVIAVVPGWAAGGGHSLHVVCDLTLASVEHGRFKQTDADVASFDGGFGSAYLARQVGQKFARQIFFLAETYTAEDGVRMGTVNAAVAHEDLERTALEWAAKVNAKSPTSQRMLKYAFNLIDDGLVGQQLFAGEATRLAYGTEEAAEGRDAFLEKRPPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSI6</accession>
    <name>A0A7K0JSI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium:proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_09210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000425">
        <property type="protein sequence ID" value="MST32895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="228"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST32895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="313" mass="32654" checksum="19AEC1DEB489911E" modified="2021-04-07" version="1">GISGSGAAHVAVEFVVQMAVGLAVGVVGGRLLLVFMRRVPLPGGGLYPLRTLASAFLLYGAATVAHGSGFLAVFIAGITVGDARAPFKREIERFHDALSSLGEIVAFIALGLTVDLGTEARTDVWVPGVVIALALMVLIRPLLVGLSLAPVRLRRNERAFILFAGLKGAVPILLAGYLLTAHVPAARRLYGIVVVVVLFSVVVQGGLVGTFARLVHLPMEVVPPEPWALGVRLRDRPSGVYRLQVGEDAPVAGHTVAELPGLPEGAWITLLVRDGRLLAVRGSTRLEPGDDVTVLAAADDGEQLSAAFGQDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JST8</accession>
    <name>A0A7K0JST8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000451">
        <property type="protein sequence ID" value="MST33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029814949" evidence="2">
        <location>
            <begin position="18"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="470" mass="49209" checksum="45C5134E7A61E40A" modified="2021-04-07" version="1">MSAVSFRRSTRRVTRFAAPAALGLATALFAAGCGASSTPSSSSTPGSSSGSSSGSTSDPGKTVDVVLWESHKATSPAGKAEQAIVNMFNASQHGVHVKLLITSGSTNGLAAAQAGHPPILAEVSHYDGAFRNGGLIVDQTPLMDGAGGFTRGQLASFYPGVLENGRIPQAIGANGQPVPGKQYRFPNGTKVEELFYDTAMFKQAGIASCPATWSALGRDLVKLKALGVTPMGFKDASAHIESVFVADGGSLYKPGSHLKQTMYDSKAGIAEFTMFRQWYQQKLFVFSHGANMRAAIANKKLAIEDGTSAGWVKVRDEAKAAGVQVSACPYPNGISGHEGNIIQGLGFVIFTHHTAAQQKAAFEFVKFWNTPKVQAYWAQASGFAPNVKSAVADIPASYLDSNAGAGLEVSIGILDSPYARPRGQSDAYAEVDQAVDAAFFDAATTTKPIGQILAKLDRTDAGYLKGSTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU5</accession>
    <name>A0A7K0JSU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000459">
        <property type="protein sequence ID" value="MST33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="119"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="548" mass="59470" checksum="F97E5569821C75BD" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSX6</accession>
    <name>A0A7K0JSX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="5" type="ORF">GHK86_09865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000459">
        <property type="protein sequence ID" value="MST33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="25826" checksum="2853745FBCF4B44B" modified="2021-04-07" version="1">MTLRTARARATRGRRSPVTEPGTARARALAARIDHTLLRPEATTDDIRRLCGEARDFRPHAVCVGSSMVAVAAAELAGTGIVVASVIGFPTGAHRRDVKASEAAAAVSDGATELDMVIDLGAAAAGDWTTVAREIAAVRSAAGAPVTLKVIIEAGLWTDEDIARACRAAEEAGADFVKTSTGFHPTGGATVEDIRVMAATVGPRLGVKASGGITTAEQALRLLGAGATRLGLSRSVAILAELETGDPVREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSY2</accession>
    <name>A0A7K0JSY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000471">
        <property type="protein sequence ID" value="MST33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="136" mass="14672" checksum="88B1F166E7F7BD88" modified="2021-04-07" version="1" fragment="single">MTAKPAPRLDSAGLEVLSERDCWELLATGGVGRIGIIRRGVPEILPISYRVVDHDILFRTGLGSRLSAALLGSSVAFEVDRLGGEGEASWSVQMLATTQVREVDPVADAALLEGLLDWAPRPGPYLVRLRPRRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JT82</accession>
    <name>A0A7K0JT82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000499">
        <property type="protein sequence ID" value="MST33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="134" mass="14470" checksum="073265B0B5AC349E" modified="2021-04-07" version="1" fragment="single">MAALAAHRVERRYAALARGAVDADEGLVDAPLGRSSRDPTRITVQAGGREARTRYRVEARFTTPEVLTLLECRLETGRTHQIRVHLAAIGHPIVGDPRYGGRRAGAVAGLLPPDRPWLHAGALAFAHPRTGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTE4</accession>
    <name>A0A7K0JTE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4012 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_10765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000518">
        <property type="protein sequence ID" value="MST33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025101">
        <property type="entry name" value="DUF4012"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13196">
        <property type="entry name" value="DUF4012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="11572" checksum="35AE7389C7647629" modified="2021-04-07" version="1" fragment="single">ALFHGHQTYLLLVGNNAEMRGGSGMALDAGTIRLGDGAISVGHLQDTGQLVDQFPGVRPSGDLAARWGFEYPQLDLRELFMSPQFPANAALAARMWQAHTGRPVDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTH7</accession>
    <name>A0A7K0JTH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_10955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000533">
        <property type="protein sequence ID" value="MST33237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="20792" checksum="684B398A0BE090B5" modified="2021-04-07" version="1">MEGRGIEGRAGCDAGPVTTDDLLRTVRASIAGRDPVDGREAASRARALAELDQLRSPFDRHADAVHVTGSGVVLGPEGVLLLRHRLLGIWVQPGGHLEPGETPWDAARRETAEETGLEVRLAGAGVPPPLLHLDVHGAAHGHTHLDLRYRLAVVGDPTPRPPSGESQEVAWYRSADALELADPGLRGLLVALEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM2</accession>
    <name>A0A7K0JTM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000439">
        <property type="protein sequence ID" value="MST32944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15653" checksum="26B176DBEB74BA8C" modified="2021-04-07" version="1">MKTYETPRAVAPRLVCWAHGNDVVGGRSAGPPRGWTPGGGGPMSETGEKPIRWLSTRDACERLGITLRTLYRFIDEGQLPAYKMGRVIRLQAGDVDEFIGRMRIAPGTLEHLYPEPKGHDRPADEPSRATAGDGRDAALDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM3</accession>
    <name>A0A7K0JTM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_11270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000552">
        <property type="protein sequence ID" value="MST33296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029488517" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1138" mass="114458" checksum="F8CC604D5958C85E" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTP2</accession>
    <name>A0A7K0JTP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_11375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000557">
        <property type="protein sequence ID" value="MST33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="21626" checksum="4239570B0B293B04" modified="2021-04-07" version="1">MSGSWWEKPSKITAPSSRHRGACHDRAVPHPTDPTIVYTDGACRGNPGPGGWAWAVPGGRFRSGADPRTTNQRMEVLAVLDAVTTLDGDLEVVSDSTYVVNCFRDRWWEGWERRGWRNSQRQEVANQDLWRPLIAAYKHDPDRLRFRWVKGHGSDRMNDLVDRLAVEAADTQAGRSGDAPPERVGRPDRIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTQ1</accession>
    <name>A0A7K0JTQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA dihydrouridine synthase DusB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_11345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000555">
        <property type="protein sequence ID" value="MST33310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="6">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="239" mass="24771" checksum="9ACCFE98231D7AD6" modified="2021-04-07" version="1" fragment="single">MAGVTTPAFRTLCREHGAGLYVSEMITARALVEDNARTRRMLAPAPDEPVRSVQLYGVDPAVVGAAVRRLVDDWGIDHVDLNFGCPAPKVTRKGGGAALPVHHVLFAGVVGAAVAAAGRVPVTVKMRMGVDDGARTDTRSALIAQEEGAAAVTLHARTAEQLYSGHARWDAVAALKQAVRHVPVLGNGDVWSAADALALQASTGCDGVVVGRGALGRPWLFAELAAAYAGRPLPAPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTR1</accession>
    <name>A0A7K0JTR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000553">
        <property type="protein sequence ID" value="MST33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="179" mass="19036" checksum="1F18C85868D4F8AB" modified="2021-04-07" version="1">GRAIDELLPLLRRLWSGEEVTWSGDGVALRGVRLAPVPLQDPLEVWLGGMGRAALERCGRLGDGWLPAQCTPEQAAAGREVVEAAAAAAGRTISEEHFGVSIGYASEALSPAQREALAARARGVDPAQVVPVGPDALRERLERFVAVGFSKFVLRPLQPPGDWTAELGQLRQAVGDLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTV5</accession>
    <name>A0A7K0JTV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_11595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000573">
        <property type="protein sequence ID" value="MST33358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="34429" checksum="65DC8777C0538416" modified="2021-04-07" version="1">MTMVGTAGTVAPGAAARPDGRASGPDDLDALTREVLRASAECEASLHELQARLRRAARVVQQRRLRRALAERAREGPPASTPRPRRAFEEELVRANLELAQRLSHRYRRRGESEEDLEQVATLALVAAARRFEPDRGIPFAGYATPCILGELKRHFRDRSWGMRVPRALSELYLAARTARDEMLAATGTAPTIPQLAERLECSTEEVLEAMEAGRNFRPESIDGLGEAQSRRLPSADSDEDRILDRHRLGELLPHLQPDERRMLQLRFVEGRTQASIATELGVSQMHVSRTLDRVLRRLRHQMEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTW2</accession>
    <name>A0A7K0JTW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000576">
        <property type="protein sequence ID" value="MST33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="120" mass="13846" checksum="F05CC177C72348B1" modified="2021-04-07" version="1">MGEDLRLRPPAEVFDDHLRLAGEHRFDEDIERNVSPDAVILERRGVFHGRDGARHLARLLGEELPGAPYVYTNRLVEGRFAFLEWTSEAEHTRVRDGADSFVIEDGWIVAQTIHYTVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU02</accession>
    <name>A0A7K0JU02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000454">
        <property type="protein sequence ID" value="MST33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="344" mass="37699" checksum="23F98D482A7D264C" modified="2021-04-07" version="1" fragment="single">LSPTLSGWRFSHGLLRDAAYEGLSYRRRRELHGRAARAIEQSAVGDEAAEVLSLHWLRAEEWDRTWRYARIAGERARALWANADAATFYQRAAEAARRLRLGGPDVLAVAEALGDVAELSADYGPARAAYAWGRRFAPEAVDRARLLRKLGVLHEREGHYRAALACYSRARTLLARDAGSGDPRPGTGAERAELDLASAGVMLREGRYRAGIRFASAAARDAEAAGHDRPLAHALYLQHALSVFLGEFPDHLAERSLGIFERLGDLVGAGNALNNLGISAYYRGCWPESRAYYERSREARARSGDIVGAATEENNIAEILSDQGRFDDARSLLESARAAWTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU36</accession>
    <name>A0A7K0JU36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_10280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000486">
        <property type="protein sequence ID" value="MST33104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="165" mass="18290" checksum="940B8D767500515B" modified="2021-04-07" version="1">MSDTDRGDPAERRAALRERHLRPAPERPPSAARGLHHTALVSSDVERTIRFYQDLLEFPLTELIENRDYPGSSHFFFDIGNGNLLAFFDFPGLDVGPYAEVLGGLHHVAISVEPARWHHLVAKLEAAGVEHVVHSGVSVYFRDPDGARLELIADPLGEMYGTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU51</accession>
    <name>A0A7K0JU51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="2">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">murB</name>
        <name evidence="5" type="ORF">GHK86_12190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000609">
        <property type="protein sequence ID" value="MST33476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurB_C" evidence="4">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="138" mass="14663" checksum="541824D968C2D88F" modified="2021-04-07" version="1">SSITATQVVVAAELAAAWGDPAEGRDTIRAIVRWRREHQPGGQNAGSVFTNPPPGGGEARYAGALVEAAGLKGWRRGSATVSPKHANFIQADPGGSADDVYRLLREVQARVAERFGVELHTEVRLIGFEPSMSTGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUG0</accession>
    <name>A0A7K0JUG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_12760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000650">
        <property type="protein sequence ID" value="MST33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="37" mass="3939" checksum="E92E232C62DD719E" modified="2021-04-07" version="1" fragment="single">MERPAEVAVVGAGPVGLTLAVLLAQRGRRVTVLERRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUK6</accession>
    <name>A0A7K0JUK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_12935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000665">
        <property type="protein sequence ID" value="MST33621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="483" mass="51764" checksum="E31476174DA7B559" modified="2021-04-07" version="1">MARDQQPAPTLEEELPTTLRRGAVGTLEAAFQSFSYVAPAGDVAILLIGTVIYAGGATPLAVIIAWLIYGLWMVTPVEFSRMITNAGSYYAYSARGFKGGGALALWYWMGENVTGPSFAVLGLSSFIYVLFSSLARTGWAWLPMAIAILVFGVALSYRGVRPSTKFTLLSGSFEAIFLIVTAVIIIFMAGSKNSATPFTLTTIHGSFHLLFLAVIFSILDFTGLGTATTLSEEVEGSKRKIKKALWIGWFVSGLAVIIPAYALTIGWGVHSMAGYGKSADPGLIVYKHFLGPVGWGILIAVTITSYLSYMVAKVNAVTRIWFAGGRDGVYFRRVQGVHTKFRTPYQAVALFFGVILVVNVAAGIVLGPANGSLWLLTISGVCIIAVHIVANTALTVYMTRPGRRFRPLLHGVIPSVSTVLGGVVIYYSVYPLPAGAIRSAVIISLVWLVAGFVAAAYYVRRHPDALRLGGRSRGEEALVPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUQ3</accession>
    <name>A0A7K0JUQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TraR/DksA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_11255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000548">
        <property type="protein sequence ID" value="MST33294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10809" checksum="2390C87F49404C77" modified="2021-04-07" version="1" fragment="single">MDAERAATVARLAALHAEVEGIVESSRDANLDDECDPEGATVAFERQRVAALEAEARAHLAAIDAAEARLAGGAYGVCDDCGGPIGAERLEALPTTTRCVACAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV01</accession>
    <name>A0A7K0JV01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000730">
        <property type="protein sequence ID" value="MST33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="21818" checksum="ECEFFCFA032931BD" modified="2021-04-07" version="1">RALRTGGEPLDRAWRAPATRPRRLVLLVDVSGSMDAYARALLRFAHAAVSARGPSRCEVFTLGTRLTRVTRHLGDRDPDAALGAAAGAVDDWSGGTRLGEALREFNDRWGSRGTARGAVVVILSDGWDRGEPDALAEQMARLGRVAHRVVWVNPLKASPGYAPLARGMAAALPHVDQFVEGHSLAALEQLAAVVGGTSPFAKEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV53</accession>
    <name>A0A7K0JV53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_14110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000745">
        <property type="protein sequence ID" value="MST33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="137"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="260" mass="27757" checksum="1B64BFC8723D9213" modified="2021-04-07" version="1">MSRRAKHVEEEAHDNHERWLLTYSDMITLLMVLFIVLFALGQTNIRKFNAFRQSFHTAAIQPAPVTTGGIGVLSADSAVQLDPSPATHDPHVTPRVGTNPAASSGAAQALAQTQAAIEAALRRAGLGSDVRFRTTADGLAVTIATDKILFPTDSATLLPLGIQVLRVITPILARIHNDLDIEGHTDNVPITGGPYPNNWALSTARALAVLEDLRAGHVPADRMVASGFADTRPLVPNTTPANRALNRRVEIVVLTAPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV86</accession>
    <name>A0A7K0JV86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Family 65 glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_13880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000732">
        <property type="protein sequence ID" value="MST33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="7">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="5">
        <location>
            <begin position="333"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="6">
        <location>
            <begin position="706"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="598"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="790" mass="87800" checksum="38B33AFB6EBB95D2" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVA1</accession>
    <name>A0A7K0JVA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sigma70_r2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_14350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000764">
        <property type="protein sequence ID" value="MST33895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="96"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="168" mass="18277" checksum="683512E58ECA6BC0" modified="2021-04-07" version="1" fragment="single">MLVVQAQPVGHHGPVPGQQLVVDRHRSSRRAREGVGTSLTAGPPAVTARSGSPGPGGRAPTLPPRIFRLATQHRGPSATLWVVVRPAEVPPGFAAWYEAHHPRLVTVLRAVTTDADAAADAADEAMARCLLHWERVRHMASPAGWTYRVALNELRRVGRRRALEQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVB6</accession>
    <name>A0A7K0JVB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_14315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000762">
        <property type="protein sequence ID" value="MST33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="192" mass="20763" checksum="B61E7B828F0262B6" modified="2021-04-07" version="1">MTALPAVEHLVRTRLRTLRRSLGLSLDELAARTSLSPSTISRVETGKRTISLDILLPLARALQVDLDALLDVPGDEDVVIRPTPSCSGERTTWLLSRPTDSTVAAKLRLLPTSTPPDPQVHPGHDWFFVTAGRVRLTLGERELTVEAGEAAEFATMTPHAIAAVGGPAELIMIFDREGQRAHVHHEAAGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVG3</accession>
    <name>A0A7K0JVG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2236 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_14655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000787">
        <property type="protein sequence ID" value="MST33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="58"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST33955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="322" mass="35191" checksum="F68F5FF3FA63714D" modified="2021-04-07" version="1">MLVFDLIAGLVIVGIVPGPAAPRRRRPLTAAGGPSLGSAHVARPARPRSAPGPGSLTWELLGDVRGLLMAPATLVLQVAHPVVGAGVAQHSRFRTDPWRRLTRTISSTVRFTYGTDAVAGPEAARLRHLHAGIAGTDDRGRPYRALDPAAYAWVHLTLAHFAVDVRRVLGRPLTPAQRAAFYAEWRRVGLRLGVADAEMPPDWPAFLDYFDAVLHTTLEDNQSVRDVLDVVRRPPPPTRRIPDALWDPLAVRAGTLQTLFTVGTLPTPMRERLALAWTDADQRRLEQRASVVRGLFSALPAPLRTYPQVLPHVLEARFTSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVS2</accession>
    <name>A0A7K0JVS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000822">
        <property type="protein sequence ID" value="MST34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="10603" checksum="BDBF7CCC54D87E0A" modified="2021-04-07" version="1">MTDDRSDKRRELVARLSDAAAELDDLHVVARDHAPFGSGDLLSLADELQAMTARLHEHAGHLAVDVVLHPAPSLPAGGAGEPVVAPDALDPLHAGCGGVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVU0</accession>
    <name>A0A7K0JVU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_15195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000831">
        <property type="protein sequence ID" value="MST34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="142" mass="15483" checksum="8DB1ACCDBE022FCE" modified="2021-04-07" version="1">VALLVLSGSAVAGGLPFYAILALPVLFAAGMSLFDMLDGCFMNFAYDWAFSRPVRKVYYNLTITGLSVFVALFIGAVETFGLLGQESGLHGAFWRFVGGFDLNTAGFVIVGVFVLTWVVALLVWRFADIERRWDAGLRAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVW9</accession>
    <name>A0A7K0JVW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03960 family B12-binding radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000845">
        <property type="protein sequence ID" value="MST34088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3" evidence="1">
        <location>
            <begin position="262"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="649" mass="71550" checksum="ABD3EF4C65B0B559" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX7</accession>
    <name>A0A7K0JVX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000854">
        <property type="protein sequence ID" value="MST34110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="111"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="2">
        <location>
            <begin position="230"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="297" mass="31860" checksum="8BA6BDB7AE266F1C" modified="2021-04-07" version="1">LGAERLLTSVGHAVVVTDLAGAVQYWNPAAERLYGWAAADALGRRARDLLAPRLSRGTAEGILATLADGVAWTGTVQVQHSDGTLFPALVTSNGVFDDGRLVGVVGAAIGLHQALRPLLEDSPDAVLVVTPDGRVGFVSQAATRLFGWTGPELIGSDVLHLVHPGDRSDVSHRLAAADRGQHQAQCPAEWRVRGRCGWRWVEAVAGSLGDPSAHGVVLSLRDVTDRREDRERLARLSEQLQVALSSRVVIEQAKGFVAASRAVDLDEAFAVLRQYARSHNQTLHEVATAVVTRRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ1</accession>
    <name>A0A7K0JVZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">GHK86_13400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01000695">
        <property type="protein sequence ID" value="MST33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="239" mass="24857" checksum="32A1DA4F4E1EA8AE" modified="2021-04-07" version="1">MPPVTAPPDAGTTLPEGDDKRRAVRAMFDTIAPRYDLVNRVMTFGMDRGWRRAAVGSLGLDPGSRVLDVACGTGDLCRDLAGAGYRPVGVDLSSGMLRHARTAAPLLHADALVLPFADGALDGAVSGFALRNFVGLPPLFAELARVVRPGGRIALLDVATPTHPLVRAGHAVYFGRVVPLVGAALSDAAAYRYLPRSVAYLPPVAVMLDALRGAGFGAVERLPLSGGITQLLTATRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVZ3</accession>
    <name>A0A7K0JVZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Betaine/proline/choline family ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_13485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000701">
        <property type="protein sequence ID" value="MST33724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="310" mass="33509" checksum="B18672220CD7257F" modified="2021-04-07" version="1" fragment="single">MTTVTPRSEAEVACRGLWKVYGDGGRELLASGAVTRSRAELLAESGCVVAVRDVSFEVARGEVFVVMGLSGSGKSSLIRCLTRLVDVTAGEIRIGGLDVLSADAEQLRQLRRRKVSMVFQHFALFPHRRVIDNVAFGLEVQGIGKAQRHERAREVLGVVGLADVERSYPSQLSGGMQQRVGLARALAVDPDVLIFDEAFSALDPLIRREMQDEVIRLQEKMHKTVVFVSHDLDEALKIGDRIAIMKDGAFVQVGRPQEIVGAPVDDYVRDFVRGVARGKVLTAEWMLAGADPGTPAGTVPAATVPAATVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW66</accession>
    <name>A0A7K0JW66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000892">
        <property type="protein sequence ID" value="MST34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="9231" checksum="07E58FCEE1BF534D" modified="2021-04-07" version="1">MKKRRVTLNLDEDVVDALTATTGGRSLSAAANDALRQAVATEAHRGALSRWLDELDALHGRATPEETDAIEAFVEEVARSSTSPGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW68</accession>
    <name>A0A7K0JW68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_15865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000890">
        <property type="protein sequence ID" value="MST34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="48"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="183" mass="18633" checksum="D2C225560D2F9387" modified="2021-04-07" version="1">MWPVPPLRLGTLEAGPASARPDLLAAPTLAALRAGGWLDAAGVVEIDPGRSDTAATRDAYGVPEDALANCVIVAGRREGVERLAACVVLAATRADVNGVVRRRLDVRKASFLPTGRAVELTGMAVGAITPVGLPPGWPVLLDRRVADADLVIVGSGIRASKLLVAGSLLAALPAAEVVDGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW72</accession>
    <name>A0A7K0JW72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_15935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000895">
        <property type="protein sequence ID" value="MST34205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="49" mass="5036" checksum="6525621C71228069" modified="2021-04-07" version="1" fragment="single">MPAGERHLRLLLEAAVDPHRAPADPEAELAVAGDALAAVGLVDPALARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW97</accession>
    <name>A0A7K0JW97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000900">
        <property type="protein sequence ID" value="MST34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="19070" checksum="9B8C6DF8094757FE" modified="2021-04-07" version="1">MPDDARRVRAAEPTDAPAIGLAHVRSWQAAYRGRVPQDYLDALDADRRGEGWRRYLEAGPPGGEALLVVDVDDRVVGFANVGPSRDDDAAGGGELRAIYLLPERWGLGDGRALLAAATRALHAHGFGHATLWVLDGNERARRFYEAAGWAPDGATKEDLSFGFPVAEVRYRRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA5</accession>
    <name>A0A7K0JWA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transgly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000910">
        <property type="protein sequence ID" value="MST34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transgly" evidence="1">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="200" mass="21354" checksum="6FC2A93D2C731451" modified="2021-04-07" version="1">MQRLLAEHGGRPITAPPPPRLAASLVAAEDQYFYSDILVNVAEGAGRAGLALLRHRGDPGGSTIPQQLAKQLWPQHPGFVGVADDVGIGVKLGLRYSKPAILAMYLNAVYFGNGYWGVAAAAEGYFGRSPGRLDWAQASLLAGLPQAPSAYDPFRDLPLAKRRQRYVLDQLVSTGRLTAAQARRAYAAPLGLRVAVRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWE9</accession>
    <name>A0A7K0JWE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">GHK86_16300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000926">
        <property type="protein sequence ID" value="MST34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="119" mass="13129" checksum="2FE44D8FA828FB4B" modified="2021-04-07" version="1">MDTSGGGGQNGPSPCPTPRRDDASPAGETDRDPTRNALPVDKNTTLGWRQRAACRGVDPDIFYPVTDEEAEDARSICLGCGVREACLEWALGNRERDGVWGGATERERRRMIRQRRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWG2</accession>
    <name>A0A7K0JWG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GHK86_16370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000931">
        <property type="protein sequence ID" value="MST34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="41"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="280" mass="29871" checksum="4B1AA438313FB3EA" modified="2021-04-07" version="1">GVAAVTPPRVNPAGTAAVAGVIPTTAPQAARTTALLHRLRRDVIPPAEAGTGLHVLVGGATAGQVDFAGVLSSKLPQFIGAVVVVAFLLLMVVFRSLLIPVIASIMNLLSVGAALGLMTVFFERGWGDWLTGAHGTTPVEVFIPVIMFSILFGLSMDYEVFLVSRMHEEWTRSGDNRRAVTLGQTETGRVITAAALIMILVFLSFLLGGSVIIDQFGVGLAGAIIIDAFVVRTVLVPALMHLFGRANWWLPPWMERHLPHLAVDVPDTPTDAEEPMELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWH3</accession>
    <name>A0A7K0JWH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GHK86_16420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000936">
        <property type="protein sequence ID" value="MST34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MST34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="36493" checksum="BD536FF84DA0F286" modified="2021-04-07" version="1">MPRRPPGPGRGEDVHAVPNNHAAQPEEDLVRLYLNDIGKHALLTKDDEARLAQAIEAGREARAEMGSGKNLTPARKRELRRLVRDGDEAAETFVKANLRLVVSIAKKYQAAELPLLDLVQEGNLGLMHAVEKFDWRKGFKFSTYATWWIRQAITRGIANTGRTVRLPVHAGDLLTRVTKARGRLEGQLGRRPTVAELAADLELEEEKVTEILRHAAEPLSLSEPLREDGDAELGDVVEDRSAVSPFDAAAASLLSGEVNKMLIALDEREREILRLRFGLDRGEPRTLDEVGEHFSLTRERIRQIEARAMSKLRHPSTDRGARELLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWQ6</accession>
    <name>A0A7K0JWQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_16825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000974">
        <property type="protein sequence ID" value="MST34377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="306" mass="32244" checksum="872044040EDA95D5" modified="2021-04-07" version="1">MQAIEVEGLIVRYGEVVAVDDLHLTAEAGRVLALLGPNGAGKTSTVETLEGYRPRAAGSVRILGLDPARDHAALTARVGVMLQRGGVYPGMGPAEALRLFAAFYRRPLDPAELLERVGLGDVARTPWRRLSGGEQQRLSLALALVGRPEVVFLDEPTAGVDVQGRQVIRAVIAGLRDEGVCVVLTTHQLEEAERLADRVVIIDHGRVVADGSPAELVTETAGRSIRFGAPAGIAVSDLATRLGAPVLEVDPGEYEVQAPATPAAVAALTAWLAERELPLADLRAGRERLEDVFLRLTATGGDGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX55</accession>
    <name>A0A7K0JX55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001056">
        <property type="protein sequence ID" value="MST34533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029804924" evidence="1">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="15411" checksum="9EEEEC77781BED2A" modified="2021-04-07" version="1" fragment="single">MPATHATGSWRIRLALLLGAALAAVAPAGRAMAATPAQPTWSMLSPPTSPPPLRDAAAAYDAANQTVVVFGGMLPDGALSNQTWVWNGTTWSRGDHGYGAIPPAREGASMAYDAGLNQLILFGGAATNGTLLDDTWLWNGASWIQVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXK0</accession>
    <name>A0A7K0JXK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001143">
        <property type="protein sequence ID" value="MST34676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="10088" checksum="F79C324DFDA11E75" modified="2021-04-07" version="1">MDPRQLKMWVKLATVGIGLVITVWSLRAAPLLGGGSGPSTPGNIAGNGIAGVCQEQKVAQQLSGTTGAGASSAGTLATAGMSGGARALLQQLNGGSLTCPTTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXP2</accession>
    <name>A0A7K0JXP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_18575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001175">
        <property type="protein sequence ID" value="MST34720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="139"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="4">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST34720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="301" mass="31708" checksum="2BFAB08B06DAA2FC" modified="2021-04-07" version="1">GRVLSSPDRAELGRRAPAALLAAVARHPSSTWVGQTAGRVPTVVAVAPVGVAGYHLVITQPAPDFYGSLWHGDVSLRWALTALLVVVAGALLVLHTRRQAAVHAVADMALRDTLTGLPSRLAFTQALEEAMERHRRDGVEVALLFCDLDGFKAVNDRLGHAAGDRLLVAVAQRLHAAVAAHADDRKAVMARLGGDEFTVLLESPHASPHAQQLANALTESLDQPFALGDGEVRIGVSVGIAYAHPDRDLLLDADVSMYRTKAIRRVSRRAADPDRTPPTGLSGAGTQGTRVTDTAGADAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU7</accession>
    <name>A0A7K0JXU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001209">
        <property type="protein sequence ID" value="MST34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="240" mass="25646" checksum="3342808FB683497E" modified="2021-04-07" version="1" fragment="single">MAAAAVARVLALGFTRLRPRAARPLLLRRSAALCTAAILVALSVPAVQEVGAYTARNAGDISLQRSEAVPAAAELAPLLARIKAGGGGRTYAGNPNNWGASFDVGLVPVYKYIESQDIDEVGFTLRTASLMSQPEFHFDQYQPADFPAFGIRWLIYPPGQPLPPGYRYVMHRGPYWLYELPADGYVSVVDTVGTLRANRTDVGPVTAGYLAGPMFAQHRELTVGWAGAPAPAPTAPGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXY1</accession>
    <name>A0A7K0JXY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_18975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001219">
        <property type="protein sequence ID" value="MST34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="219" mass="24011" checksum="CD1ADEB75B59D6E3" modified="2021-04-07" version="1">MDDLALLARSELFSAFDSESLERVLSASTTITGDRGLVLFAEGDDADDLYVVRAGRVAVGRRSPDGRESLVALMEPGDLFGDMPLFDGGTRSASARLLEASELLRIPYGPVKAVIDDHPALLWDVVTLLTGRLRATDSALADAVFLDVTGRTAKRLLELAGDADDFQLPITQEELAGLVGASRERVNKAIAAFIRLGWIEQYDRRYRVVHRDRLAQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY11</accession>
    <name>A0A7K0JY11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001243">
        <property type="protein sequence ID" value="MST34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="104" mass="11277" checksum="A577BFC09B9EAA9A" modified="2021-04-07" version="1">MSQIRVPLSVFDDKVQAHRVDAGPEGVCLVRIVDRYFAISDRCSHAEVSLSQGDVDPEDCSIECWKHGSAFSLLDGEPQSLPATVPVPVYPVAVDGDELVVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY74</accession>
    <name>A0A7K0JY74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001295">
        <property type="protein sequence ID" value="MST34911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="78" mass="8146" checksum="64B8A561C142E0A7" modified="2021-04-07" version="1" fragment="single">MDVVLRWIVEAAGEELAAVELWDRGATAVAVEPAGGRVALVASFPTADAAREVAAELGAGVDEVDGGWRDAWKAWAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY88</accession>
    <name>A0A7K0JY88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001255">
        <property type="protein sequence ID" value="MST34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="199" mass="22146" checksum="C87B5E8895417F29" modified="2021-04-07" version="1">PALRRGRRYLAAYLGVMGPQDGVDLVLRVADVVIHRLGRRDVAFTLVGSGDCFVELCALRDELGLAGDVELTGRLPDAEVAAVLSTADVGLSPDPKNPLNDVSTMNKTMEYMAFELPVVAFDLRETRVSAGEAAAYATPNEVEDYARLLVELLDDEPRRRRMGALGRRRVVEELAWDYQAVRYLDVYRRLLDSRPLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYC0</accession>
    <name>A0A7K0JYC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme ABC exporter ATP-binding protein CcmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ccmA</name>
        <name evidence="7" type="ORF">GHK86_17575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001052">
        <property type="protein sequence ID" value="MST34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005895">
        <property type="entry name" value="ABC_transptr_haem_export_CcmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01189">
        <property type="entry name" value="ccmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="238" mass="24268" checksum="2A149C35F4526E89" modified="2021-04-07" version="1">MDPVIRLRSAVALVGRFPVLAGVDLDVSPAEIVLLQGANGAGKTSILRACAGLLRVVAGEACVLGVDLTGDARAVRRRVGLLGHATALYDDLTVVDNVTFAVRASGADRAGVAPALAHLGLTGRLPRTRVAALSAGQRRRVALATLVARDPELWLLDEPHAGLDAEHRDLLDELILAAVGRGRTVVLASHERHRAHALAGRIVTVAGGATAPAVPATPGDAASAGPPVVADPEATSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYL4</accession>
    <name>A0A7K0JYL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="12">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GHK86_20250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="12"/>
    <dbReference type="EMBL" id="WJHE01001385">
        <property type="protein sequence ID" value="MST35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MST35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="135" mass="13424" checksum="61479C6CFF7B06AE" modified="2021-04-07" version="1">VLLGDLEALVAELRPDAVVVERVLFQVNARTAMSVGQASGLALAAAARAGCPVVEYSPNEVKLAVTGDGSAGKAQVQRMVATLLGLPAVVGPPDRADALALAVCHLSGARLRQAASVASVASVASVASVAGRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYP4</accession>
    <name>A0A7K0JYP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r4_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001413">
        <property type="protein sequence ID" value="MST35078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="149" mass="15099" checksum="98DE750FBF9A8849" modified="2021-04-07" version="1">AAAESALAAALTAGGDRGGVPTSGEVTRRIRAALAQVRPGSELRSGADALMALGEGLAEVLACNEEFAWLPAAALESALGLLAPADAELLRACYLEERTVEELAEATGLSPASVLARRSAALRALGDRLAVSVAGAVPSPGPRAMLHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYR2</accession>
    <name>A0A7K0JYR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">purS</name>
        <name evidence="6" type="ORF">GHK86_20500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01001427">
        <property type="protein sequence ID" value="MST35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="85" mass="9141" checksum="F0DE4A8DC05CCF3C" modified="2021-04-07" version="1">MSRFAALVEVRLRPGIADPAGTTIERSLPALGFADVTGVRTGKAIRLEVEADDADTARSRVEELCRRFLTNPVIEDAEVTVEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYT2</accession>
    <name>A0A7K0JYT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_20445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001419">
        <property type="protein sequence ID" value="MST35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="87" mass="8989" checksum="8059E891FE671E95" modified="2021-04-07" version="1">ALPDDAVLVRANAATQVAAGALLAAGVAERPAAMVLAASLLPTTLAGHAYWAVEDRAQRPNQRNHFNKNLAIMGALVLAARRRPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYU5</accession>
    <name>A0A7K0JYU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001449">
        <property type="protein sequence ID" value="MST35123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="71" mass="7850" checksum="8874EA5C5FF4622D" modified="2021-04-07" version="1">MLVFDLIAGLVIVGIVLAILLIGIGHGARFQDQLEAQRDRRAVVPGRFGQRELDEALRGVVRSRQDERQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYV3</accession>
    <name>A0A7K0JYV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_20700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001461">
        <property type="protein sequence ID" value="MST35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="109" mass="11968" checksum="E5331C441941F087" modified="2021-04-07" version="1" fragment="single">MPRTVAPHGSWTSPITAERLVERAIGVQDVTTHGGRIAWCESRPNEEGRYVVVAAGPDGEPVELTPPGFSTRTQVHEYGGRCWTLDGADLIGSNWEDQRLWRFAPGAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYX5</accession>
    <name>A0A7K0JYX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001477">
        <property type="protein sequence ID" value="MST35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="175" mass="19140" checksum="1F98E390B5FAF800" modified="2021-04-07" version="1" fragment="single">AAISRMAAPDGPRRLVVVAPTAHLKRQWAAAATRFGVHLDDQWSAGEPLPPDMHGIVTTYQQVAVSAPQLAVAARGAMVVFDEIHHAGDERTWGETVRSAFGAAACRLSLSGTPFRSDTRSIPFLRYELDEARPDFEYGYGEALRDGRVVRPVYFPRTNGQMEWSAPDGSTWSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ05</accession>
    <name>A0A7K0JZ05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001211">
        <property type="protein sequence ID" value="MST34779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="103" mass="10519" checksum="AEC7511A55A033B8" modified="2021-04-07" version="1" fragment="single">MAVLDTVGMFDLAETWPDQVEASAAAARGLEGLPRSEEIEQVVVFGMGGSGMAGDVLAAVATPQMPVPVVVVKSYECPAFVGDSTLVFAVSASGDTEETLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ57</accession>
    <name>A0A7K0JZ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001487">
        <property type="protein sequence ID" value="MST35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="258" mass="28188" checksum="57802D2DBF02D429" modified="2021-04-07" version="1">RLPQPILLEGEAGVGKTEAAKALAAVLDTPLVRLQCYEGIDATEALYEWNFPRQLLEIRLAEVGGSAPGAHDLFTREYLIARPLLRAVEHPGPRPAVLLVDEIDRADDEFEAFLFELLAEAAVTIPELGTIRATHPPIVVLTSNRTRDLHDALKRRCLYHWLDYPDLARTVEIVRRRVPGARAGVAGQVAAAVGRLRTLDLQKPPGVAEAIDWAHALELLGVEDLDEAALLATAGSVLKYREDVEVAAERGAAWIAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ83</accession>
    <name>A0A7K0JZ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001580">
        <property type="protein sequence ID" value="MST35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="169" mass="17802" checksum="E0C3A31EF0FE926E" modified="2021-04-07" version="1" fragment="single">MALTPPRSGLYEPTFEHDACGVAFVVDVHGRRSHRLIQLGLRALCNLEHRGASGAEADTGDGAGILLQVPDALYREVAGVALPPPGAYGTGIGFLPTGDAARREATAGFERIAAGEGLQVLAWREVPVLAATLGPTARRTMPALRQPFVAAADGAAGLALERRLWFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZC0</accession>
    <name>A0A7K0JZC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_21240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001547">
        <property type="protein sequence ID" value="MST35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="PTHR36934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="108" mass="11258" checksum="063101BC68990E92" modified="2021-04-07" version="1">EDTAAAARSGDVAVLATPRVVALCEEASVHALAGYLPEGHTSVGTRVEMAHLAAVAVGSAVRAVATLEKTEGRRLVFSVSVTDRCGLVAVGKVTRVVVERDHFVHKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZG8</accession>
    <name>A0A7K0JZG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2127 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001595">
        <property type="protein sequence ID" value="MST35298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021125">
        <property type="entry name" value="DUF2127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09900">
        <property type="entry name" value="DUF2127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="14280" checksum="A754629D6FE2FD01" modified="2021-04-07" version="1" fragment="single">RPPHHGIGADVNRLFRLPDWEVYAVGVALAAYTTILVFEMVGLWWARRWAEYLTLVEACALFPLEIYELLGGFSWVKVVSVALNVAIVAYLLLAHRLFGVRGGAAAAREALERDSGWAGVERTTPSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K053</accession>
    <name>A0A7K0K053_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_20880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001488">
        <property type="protein sequence ID" value="MST35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="215"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="286" mass="30508" checksum="FCD42D4F49109A27" modified="2021-04-07" version="1" fragment="single">MQRSFDDLGRPLIDVTFVVLDLETTGGSPVADAITEVGAVKLRGGECLGTFGTLVNPGRGIPPAITYLTGITEAMVRPAPPIEEVLPALLEFVGDAVVVGHNVAFDIRFLDAALGRSGRSRLGAPVVDTCALARRLVREEVPDCKLGTLASRLRLDHRPSHRALDDALATADLLHALLERAAGLGVTGLDDLLALPTARGHAQLGKLGLTADLPRAPGVYLFRDGAGRVLYVGKATDLRRRVRSYFGAASSGDDRRKLGPLLRELASIDHVVCSHELEARVLEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K0R3</accession>
    <name>A0A7K0K0R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001652">
        <property type="protein sequence ID" value="MST35349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="39" mass="3900" checksum="D3184B5935F015D3" modified="2021-04-07" version="1" fragment="single">MSVKQAMSGAAELVVAWEDTAAAARSGDVAVLATPRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMF5</accession>
    <name>A0A7K0JMF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_00105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000003">
        <property type="protein sequence ID" value="MST31133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="67"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="387" mass="42748" checksum="CBC9174748683459" modified="2021-04-07" version="1">MTGAGPAGRGQTAAAAGTGTGSGRRLPLAPDESPTASGTTSPEWVRISGASAIALRFRSGRFSRPFDFGGINLLLNYDDGCRSDCSYCGLARTRPGAYEEKSFIRVDWPLVSTDELVDRMAAREESLTRLCISMVTHPFAYRDTCEITRRIRAKVGTPLSILVAPPTLNRRRIEELHALGVDMVGIGLDAATEDLFRRHRTDVPAGGAGLSWSKYWSVVADSREVFGPWKVNCHVLVGLGETDADLVDLFIRLRDQQVFSYLFCFNPEPDSRLGATRKSELRRWRRIQLIKHLIESEGIGGHEVGFDRDGTLVHLRGDEATVRGAVESGLPFMTNGCPGEQGEPGCTRPYGSYRPSEPFRDFPFQLDDADLRQVDTELALHEIFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMG7</accession>
    <name>A0A7K0JMG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_00195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000006">
        <property type="protein sequence ID" value="MST31150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="151" mass="14780" checksum="930E6CE2B23542C5" modified="2021-04-07" version="1" fragment="single">MGFAATGVLVAAADTYVVVVALPAIMGGLGLGIQDLQRATPIVSGYLLGYVAVLPLLGRLSDVAGRRPVLVGCLAAFATGSVVTATAHSLGLVVAGRAIAGLGGGGMVPVTLALVADAWPIERRGLPLGIVGAVQELGSVLGPLYGAAIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMK3</accession>
    <name>A0A7K0JMK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">GHK86_00335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="WJHE01000015">
        <property type="protein sequence ID" value="MST31178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MST31178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15380" checksum="1D9D134CB4405180" modified="2021-04-07" version="1">MLLLSGPNLDLLGQREPEIYGTATLEDHRRAAAEVAAEAGYDLQHLQSNREGVLVEAIHAARATVAGIVINPGALTHYAWSLHDALAAFAGPVIELHLSNPAAREAWRHHSVISPVADAVIAGLGGDGYPLAVHALIQLVRASGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JMU2</accession>
    <name>A0A7K0JMU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF861 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_00850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000029">
        <property type="protein sequence ID" value="MST31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="123" mass="13466" checksum="55A5462280796335" modified="2021-04-07" version="1">MGVDQIRAIRMGEGDVVEPEWPEGDASPTWSEKEYRSFADATGTLFGGTWEGAPGSLRMDPYPYDEVCVMLTGRVALVDVDGGRREFGAGEAFFVPRGFRGTWETLEPSQKIFVGMQPGTEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JN17</accession>
    <name>A0A7K0JN17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ppk1</name>
        <name evidence="6" type="synonym">ppk</name>
        <name evidence="12" type="ORF">GHK86_01260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="WJHE01000045">
        <property type="protein sequence ID" value="MST31360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="51"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="166"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="373"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="545"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="667"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MST31360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="757" mass="83836" checksum="8AAA7795D3298BF3" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNB5</accession>
    <name>A0A7K0JNB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sulP</name>
        <name evidence="7" type="ORF">GHK86_01425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000056">
        <property type="protein sequence ID" value="MST31393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="440"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST31393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="569" mass="58893" checksum="4873C9563B8D6100" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNE5</accession>
    <name>A0A7K0JNE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_01265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000045">
        <property type="protein sequence ID" value="MST31361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST31361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="160" mass="16885" checksum="A78B47B944C3BA95" modified="2021-04-07" version="1">MTVPPDVAGPSGEEGEAPRGPAEPLVRAAGGAIWRRGPAGGLEVVLVHRPRYDDWSMPKGKLEVGESDEDAAVREVEEETGVAARLGVELPATTYIDRSGRTKRVRYWAMTVAAGEPGGANEVDVARWVPLGEARALLSYERDVEVLDALARAVGDGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNK9</accession>
    <name>A0A7K0JNK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000089">
        <property type="protein sequence ID" value="MST31528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="6877" checksum="D63D8527EC8421CB" modified="2021-04-07" version="1">MSVSVDKELCVSSGRCVADVPEVFAFDAEELAEVRSDAGDVDAARLRAAARNCPGQAIEVDAPPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNQ5</accession>
    <name>A0A7K0JNQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_01925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000081">
        <property type="protein sequence ID" value="MST31491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="58" mass="5991" checksum="2E5DA788426F2C49" modified="2021-04-07" version="1">MRAHAGARSPGWRVAGCGRSPTTTRRPRGVVDADAGRVRLATVGTDLGPPDPPVELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS3</accession>
    <name>A0A7K0JNS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">GHK86_00565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000021">
        <property type="protein sequence ID" value="MST31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="25013" checksum="D25D8E794F7A1F6D" modified="2021-04-07" version="1">MIRLEHVTKAYKGTTVALRDVSVDIQKGEFVFLVGPSGSGKSTFLRLVTKEEVADGGQVWVAGKEVGSLSPFKVPYLRRNIGCVFQDFRLLPTKTVYENVAFALEVIGRPRQVVKTQVPQILDLVGLGKKLRSLPGELSGGEQQRVAIARAFVNRPLILLADEPTGNLDPSTTAGIMRLLDRINKTGTTVVMATHDNTIVDSMRRRVIELDRGTVIRDQERGIYGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNS4</accession>
    <name>A0A7K0JNS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000092">
        <property type="protein sequence ID" value="MST31537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="1">
        <location>
            <begin position="356"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="585" mass="61498" checksum="94A85D573F056E12" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JNW0</accession>
    <name>A0A7K0JNW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_02810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000110">
        <property type="protein sequence ID" value="MST31660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="48" mass="5424" checksum="4CE59EE0FAF6EE62" modified="2021-04-07" version="1">MPDPTTAAGGRPTPQLSRQALDRIVDAIQRRVLDELERRGTWTHEGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JP09</accession>
    <name>A0A7K0JP09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_02545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000106">
        <property type="protein sequence ID" value="MST31611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="75"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="259" mass="28189" checksum="06C129CBCEF1081A" modified="2021-04-07" version="1">MTEGVEGRRRDQSQTVERALQLLDAVATSTEPLTTGQLAALSGLARPTAYRLLVTLERQGYLDRVRDHAFTLGYKATRMSGDRAAQQALARRARPILAALTEQVRETVNLSAPVGAALVEIDQIDPPDPIRQMSYTNVAFPLHGSSNGKLMLAGFSPAELDLYLAHPLERRTDRTITDPAELRTELEATRQRGFGLCVEELYEGINGVSGAIVDGQQLTIGYVSVSGPAFRLPPERLVEIAPTVLDACARIGEALQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPB8</accession>
    <name>A0A7K0JPB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_03235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST31741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="358" mass="39570" checksum="9DFAF9EF6930D13A" modified="2021-04-07" version="1">MRILILSWRDLRHPHAGGSEVYTQNLARHWTAGGHQVTFFCSEAPGAAADETHDGYQIVRRGKRLSVYREARRWYREHGRGRFDVVLDVINTRPFLAVRWVDDAPVVALAHQVCREVWRYEMPLPLALVGRYWLEPRWLAAYRDTLTITVSESSRESLEDYGLTRLEVVPEGVDGDLSTRGRVAKEPVPTLIWVGRLSANKRPGHAVEAFRLLRRRVPDARLWMVGDGPLRASLERDAPDGVGFFGRVDQDTKQDLMARAHLLVATSVREGWGLIVSEAALVGTPTVAYDVAGLRDSVTAAGGWLCPPDPTALAERLPAALARLRRAPGGGTGTVSWSEVADGVLAQLLSGISPILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPC2</accession>
    <name>A0A7K0JPC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_03655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000148">
        <property type="protein sequence ID" value="MST31822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST31822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="19169" checksum="A13C7D2A7C7839D5" modified="2021-04-07" version="1" fragment="single">MLALVVGAGSVAFAADAHAVSRERAVCRRDRARLSTVLASLSRAYFAQIAEAQGMAAASSAGTLATQPSAALDAVAGRLPGAESAVLTARSGAVLGATADAGPLLARLPRIVGSARSMLAAGGLGVSPIVDVAGSPSVVVVVPAGASGLLAVGYQLQGMAIARYGRATAVGPGAASRVLDATGRVLSSPDRAELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPE8</accession>
    <name>A0A7K0JPE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaE</name>
        <name evidence="8" type="ORF">GHK86_03725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000152">
        <property type="protein sequence ID" value="MST31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST31836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130678" checksum="2BD6CFA713187475" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPG3</accession>
    <name>A0A7K0JPG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HDOD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000155">
        <property type="protein sequence ID" value="MST31856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="197"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST31856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="403" mass="43406" checksum="CB5CD7768A32D533" modified="2021-04-07" version="1">MPGDYLVGRQPIFDTSCEVLGYELLFRGDRSLVGDGLRMTADVLVRATLDIGLGDVVGNKLAFVNAPREFLVGRQELLLPPEQAVVEVLEDVIHDAEVVAGCRRLVDTGYTLALDDYVWQPGDEPLLELASIVKLDVLAIPPEDLAAQVDACSAFGARLVAEKIETYEQLAECRRLGFELFQGYVLSKPEVLNAASLTPNRVAVLGLISKVCDEETPVEELQRLVETDVSLSVRLLRVAGAGAGRGLRRPLGSVREAVVLLGRQRLRSWLLLMLAGDTGEAKPAQMEIPMTRAKACELVVDELRPELADSAFTVGLLSGLDLLIGAPVADIVGHLAVDDRVSGALLERSGLLGAVLQDVLDWEVGRPPAARSRCGAPCDVLERAYIEALRWTTGFGALGVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JPY5</accession>
    <name>A0A7K0JPY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_02610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000107">
        <property type="protein sequence ID" value="MST31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00885">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="2">
        <location>
            <begin position="189"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="475" mass="52376" checksum="C207C20E49EC4A6D" modified="2021-04-07" version="1">MSATDEWDDLVAEIDGIRPAAQLHEPSSHYEMSELGNARRLVDTFGADLRYVPQWGRWLAWDGSRWAVDSTGQVERCAKATAEAILDEARAVGDDKRFRHGLRAQSASGVRNTVALAGTEPGVPVLVDELDADPMLLGVANGTVDLRTGKLRPSERSDLLTKASRVAYDMDAGCPGFEAFLADILPDPEVRAFLQRFAGYSLTGDVSEHALLVCYGVGANGKSTLLRLLLRLLGEHSIPAPPRLLIADRHPEHPTSVASLHGRRLAVVMEVDEGARWDEATVKNLTGGDRLTARYMRQDFWDFAPTHKFIVATNHKPTVRGGDLGIWRRINLVPFEVTVPPERQDPHLAERLEAELPGILNWALRGCLIWQRDGLGVPAAIREATEAYRAEQDVLAQFLGEVTVTTPVGKVNGGQLYRAYTSWCATQGLDHPLSQKAFVSRLQDRGLRSETDRSKARWWLGIALPIQEAPRGADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ47</accession>
    <name>A0A7K0JQ47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">GHK86_04660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="WJHE01000196">
        <property type="protein sequence ID" value="MST32017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MST32017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="340" mass="35363" checksum="548F57718567E898" modified="2021-04-07" version="1">MALTVGVYGATGQVGGVMRAILAERHFPYDRLRFFASARSAGRVLDGVTVEDVAAADHRGVDLALFSMGATASREWAPKVAAAGATVIDNSSAWRMDPDVPLVVPEVNGAELGRIPKGIVGNPNCTTMVCMPPLGVLHAEAGLTRLVVSTYQAVSGAGLAGVAELDEQVRAVGEKAAALTFDGAAVPFPPADSFPGPIAFNVLPHAGSFVDDETSEEKKFRDESRKILGIPGLRVSTTCVRVPVFTGHSQAINAEFERPLSPERARELLATAPGVRLVDVPTPLAAAGTDPSLVGRIRADEGVPDGRGLALFVVGDNLRKGAALNAVQIAEALLVHGGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQ89</accession>
    <name>A0A7K0JQ89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_03200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000127">
        <property type="protein sequence ID" value="MST31734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST31734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="208" mass="22966" checksum="3BFABECBBB082AED" modified="2021-04-07" version="1">MRASDVAYEAVRHQILDLTLPPGAILNEHALARELDLGRMPVREALARLAGDQLLEVVPRRGAVVAPLDLDTVVAIFDAREAVECGIAHVVTRRATAEQLVHLREMIEAAEAAKEGTAVEIFLQHDCSIHRYLLDMMGNHLLHAVGERLIQHNLRFWRSFFATSPAAADTMMSHLPLLAALEAHDGPAAQEAMRDHLNAARQLLKSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQM3</accession>
    <name>A0A7K0JQM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">GHK86_05780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="WJHE01000250">
        <property type="protein sequence ID" value="MST32232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="327" mass="34625" checksum="F419444E77FEA5ED" modified="2021-04-07" version="1">MTILVTGGAGYIGSHTARLLAERGRDVVLLDSLERGHRRAARDLPLVVGDIADGATVRSVVADHHVDALVHFAAYKAAGESMEHPGRYFRNNVGATAALLEAAGEAGVERVVFSSSAAVYGTPEVLPVTEDAPIAAENPYGESKALVERMLAWTDRTAGTRSVSLRYFNAAGAWPDGSLGEDWSLTTNLVPVVMKALLGRRPPLEVFGTDYPTPDGTAIRDYVHVLDLAEAHAAALAYLEEGGASTVVNLGTGVGSSVRQVLDAAERAAGREVPHTLAPRRPGDPSAVYADNRRAAEILGWEPRFALDDVVASAWAWHSSHPDGHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQQ3</accession>
    <name>A0A7K0JQQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_05950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000259">
        <property type="protein sequence ID" value="MST32266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="292" mass="31354" checksum="19BCF129D55D8889" modified="2021-04-07" version="1">MGSPAAEGSRRLTLSELVACTSVPASTIHHYLRAGLMPPPLREAPNRFSYDERHVTALRYIRALRGRRGMRLEEIAEELPQLLAHQDGDALGGEDSDEGDATCRLLEAAAEAFRTRSFAEVTVGEIAEAAHVGKGSVYRHFSSKEELFTATVERLLARTEVDFAETIERLGGPDGVATAPEKTAGEFARLVAVTMPVLLELGARAAKGHEPSRELARRVLSTMAEAAGRPLTPGSEDPEEPADPIPAGITVIKDAFSTVLSWAVGPDWPAGVWPDDDLAEDDDDLGDLAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JQR4</accession>
    <name>A0A7K0JQR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_05805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000252">
        <property type="protein sequence ID" value="MST32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="86" mass="8154" checksum="239542B6B13A81A8" modified="2021-04-07" version="1" fragment="single">MGVVVLVGAADVGGLVVVGGVVVELVVDGALVGGVVVDGGLVVEVVVVDGAVVVDGVTVVGLVGVVLGVVVVEEAAAWDLRATVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR39</accession>
    <name>A0A7K0JR39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_06635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000285">
        <property type="protein sequence ID" value="MST32395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST32395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="102" mass="11049" checksum="FB17E88EFA5B12A1" modified="2021-04-07" version="1">MPVVTAPVVARVSRSPRQVQLRRRLRGCEVVGFGPDEAHEVGALLAKPGASDFVDAHVVVTAARYGAIVVTSDVGDLRRLSDRRSVAARRIERTLFGTNADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR43</accession>
    <name>A0A7K0JR43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">GHK86_04925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="WJHE01000204">
        <property type="protein sequence ID" value="MST32069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="46"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="317"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST32069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="422" mass="42996" checksum="48368960F2DA2384" modified="2021-04-07" version="1">MRGGTVIDPTGRRPADVVVAGGVVTAVGQGLDVPAGAVELDASGCVVAPGLVDLHTHLREPGREEAETIETGARAAALGGYTAVVAMPNTEPAIDSAAVVAQVQELGRAACVEVAVAGAITVGRQGGQLAPLAEMAALGVRLFTDDGSGVQDARLMRRALEYASGLGVTLAQHCEDEALAAGGHMHEGAWSSRLGIAGQPAEAEELMVMRDIALCRLTGAPVHFLHLSTAGSLAMVRGAKAGGLPVTAEAAPHHFTLTDEAVAAFDPVFKVNPPLRGPGDVAAVKAALADGTVDAIATDHAPHPAEAKERPFDQAPPGMLGLETALALALSELDLPIESVLALLSWQPARIAGLRDSQGGPIEPGRPANLCVVDPAARWVVDPAASASRSRNTPYAGRALTGRVRHTVAAGEAVVVDGEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JR54</accession>
    <name>A0A7K0JR54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_06735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000288">
        <property type="protein sequence ID" value="MST32415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="250" mass="27023" checksum="E8C1B273EB4271DF" modified="2021-04-07" version="1">MLELAILGLLKEQDLHGYELKKRLSETLGVASGVSFGSLYPALGRLERSGAVRGVEPETAAPAAPIPQTGSLGGELAAFRARPAAVRHGRSRKVYRITPRGEELFGELLAAEPSGADDARLFSLRLAFARYLSDDARLGMLERRRLQLLERVNRSGSRARAAKDRLDTYLHSLVEHDREIAEHDLSWIERLIVREREVVAAAAEGAPAGSPAAPTDEGHVAPIPPAFPGRRERGQSLAPLGAGTDKESTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRI3</accession>
    <name>A0A7K0JRI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaK</name>
        <name evidence="10" type="ORF">GHK86_05570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000238">
        <property type="protein sequence ID" value="MST32194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MST32194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="617" mass="65863" checksum="CEE9A6859A962F3A" modified="2021-04-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRX7</accession>
    <name>A0A7K0JRX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">queF</name>
        <name evidence="2" type="ORF">GHK86_08145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000363">
        <property type="protein sequence ID" value="MST32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00818">
        <property type="entry name" value="QueF_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016856">
        <property type="entry name" value="QueF_type1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03139">
        <property type="entry name" value="QueF-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="156" mass="17266" checksum="5B5AAE41C29276A5" modified="2021-04-07" version="1">MSDADGLRALGSARTDYHLDRPDAGLLEAFPNPRPGAAWVVGLDCPEFTSLCPVTGQPDFGRLLIDYVPDGRCVESKSLKLYLFSYRNHGAFHEACVNGVADDLVGLLAPVALRVRGDFNPRGGIAIRPLALRFAEGDPARRREALELFEHYDRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JRZ7</accession>
    <name>A0A7K0JRZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4432 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_08255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000367">
        <property type="protein sequence ID" value="MST32712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027839">
        <property type="entry name" value="DUF4432"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14486">
        <property type="entry name" value="DUF4432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST32712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="35456" checksum="E455343A8CFAB4B3" modified="2021-04-07" version="1">MTCTVSEEERAGWRALVLDNGELRVAVLPEKGGDVYELVDVASGVDVLFKAPSGLRPPGSAPLRGSGDTPFLAHYEGGWQELFPSVGSSCSYRGRAVPFHGEVAVRAWDASVLSGRGSEATVELVVRCETVPLVLRRTLRLSDGSRRLVVDEEVSNRSDQATELVWGHHLVLGAPFVEDGCRLDTPASVIVTPADLWEATARLAPGQRSRWPIALGAAGAAVDLRAIPGHGAASHDDVYLTGLSAGWASVDNRRLGLRVTLGFDPELFRWLVSWQPYGGARAEPLAGSYGVGLEPWTTNLNLEDAVRAGDAVVVAGGAVLRTRLTVDLHQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH2</accession>
    <name>A0A7K0JSH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">GHK86_09215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="WJHE01000426">
        <property type="protein sequence ID" value="MST32896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST32896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="150" mass="16353" checksum="CE8EE96CC2B64BAC" modified="2021-04-07" version="1">MEGPDRLRCRLGRPAAFRVSFVATAVTVLVDTSVLIDYLRGHPDAATVLERERAGGPLQASEITRIEVLAGMRADEEEATRSLLATLVWHPVDADVAEGAGALGRRWLASHHTIDSADLAIAATVMRTGTRLLTRNVRHFPMFPGLRAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSH7</accession>
    <name>A0A7K0JSH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_09185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000422">
        <property type="protein sequence ID" value="MST32890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST32890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="118" mass="13187" checksum="DB65659CBAA52078" modified="2021-04-07" version="1" fragment="single">MGAARRANPSSVPREPRCGRRWLPVRSARPTRERKRLLKRALISVAVTTAAVSMTAAPAMAATLPKAVHHVRTYQVRRDDTYWAISHRYGVTMQDLAAFNHANLWGTLYAGTVLRIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSR3</accession>
    <name>A0A7K0JSR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000444">
        <property type="protein sequence ID" value="MST32967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="253"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="413" mass="40834" checksum="3DBF68FB6393E8BE" modified="2021-04-07" version="1">MLPENKAAPPFGEDGTGAPSQSGPGRALACPSVDNVVARADGGLARIRVPGGRIGAAALQTVADAAQRWGSGIVEITSRANLQLRGIRPGAAAALAAALVGSGVSGGPFADRRRNVLLGPLGDLDPDAEDIGPLLAPLLAALDAEPRLDGLDDKFGFAIDGGGSFGLAGRRAAVVAAPTSTSGVMGVCWGWAADGEEGSSARPRRVARSELVDALVEAAVGSLGRPRASATVPAASSAAAVRVAGPLGAGAGWVGAMPTLGRADAKAITAMAAAASRYSDGLLRLTPWRGVVFPAVAADERAALLDDIKAAGLVVDASDPASTVVACAGSRGCTSGLTDAIGDAHRIIAARRESGAPPAPVHVSGCAKCCAQHTPLAVTLVGSGPDRYDVYADGDLRARAVPSAEAVPVAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSS4</accession>
    <name>A0A7K0JSS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_09780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000451">
        <property type="protein sequence ID" value="MST33006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="239" mass="26398" checksum="787D30973069A669" modified="2021-04-07" version="1">MSTRQQVDAPPSFSRPPSVLVVEDEEEMAQLLRSGLERAGYAVDVMTDGTEVVHRVSRREYSTVVLDVLLPGPTGFEICAALRQRGRWVPVLMLTALGTTEQRVRGLEVGADDYLTKPFELVELTARVNALIRMRDATAGQVLRCGGLRLEVAAQRCFVDGREVSLTPRELSILGALMRRPGIVLTRRTLLEQVWGGDHSVAPNAVDKTIGQLRRKIGKDLLQTVHGVGYRVLDPPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JSU8</accession>
    <name>A0A7K0JSU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="6" type="ORF">GHK86_09800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="WJHE01000455">
        <property type="protein sequence ID" value="MST33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="151"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="262" mass="26122" checksum="936AA8BA4DB91118" modified="2021-04-07" version="1">ALVAGLRRARRGDADADGPGDDVVLVERLPARRRELEQRFADGGVTVTAELPPSVASAVVAVKPHDVEAACRGLAAAGARRVLSIAAGVTLSSLRGWLGDGPAVLRAMPNTPALVSAGASAVAPGPGAGEGDVAWAQGILEAVGSVEVVEERHLDAVTGLSGSGPAYLFLVAEALIDGGVLNGLPRAVAARLVTRTVLGAGRLLTESGESPEALRAAVTSPGGTTAAGLRALEARAVRAALLEAVTASAERAAELGREGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTJ3</accession>
    <name>A0A7K0JTJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_11095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000537">
        <property type="protein sequence ID" value="MST33262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="159" mass="16790" checksum="35FA8BF91211A73A" modified="2021-04-07" version="1">MTDRQRVASCVWRASPDLVVALDSRFGEPVDTYVNGSQVWIREDGPGGALVEWRLHPVAGYRRPPGLATEEVFAAVALALGTGARPPAPLEALWDGLEVFGVEPDDRIEPQPLAAAATEVLGLAPDAVGLVDHDTVGDAWERSRGGMSIVDALLGQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTL2</accession>
    <name>A0A7K0JTL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-binding alcohol dehydrogenase family protein</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_09420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01000436">
        <property type="protein sequence ID" value="MST32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="10"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="345" mass="36305" checksum="BB54F6A14C31E11E" modified="2021-04-07" version="1">MRAWEVAAPGPVDSRPLRLVERAVPEPGAGEIRIRVGACGVCRTDLHVVEGDLPPHRPTIVPGHEVVGRVDALGPGCSRVRLGDRVGVAWLAHTCGACVYCRRGAENLCSRARFTGWDVDGGYAEFLVAEEAYVYELPDGIEDVAAAPLLCAGIIGYRALRRAELPSGGRLGLYGFGGSAHLTAQVALSEGATVHVLTRGEQDRELALQLGASSARGAYDAPPEPLDAAILFAPVGDLVPVALAALDRGGTLAVAGIHLSDVPALRYQEHLFQERTLRSVTANTREDGRALLATAERVGVRATVERYPFERADEALADLSHGRFRGAAVLVLDDGGGPVTPPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JTM0</accession>
    <name>A0A7K0JTM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_11185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000544">
        <property type="protein sequence ID" value="MST33280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="55" mass="5673" checksum="97F719419DF68B03" modified="2021-04-07" version="1">MEALLVVGGFIAAAGLLWLTPKIDPDRPVEEPSAQAVTDPPPALDGPGVLEPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU27</accession>
    <name>A0A7K0JU27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_12000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000595">
        <property type="protein sequence ID" value="MST33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="401" mass="43302" checksum="7D55130190283412" modified="2021-04-07" version="1" fragment="single">MPAKRDFAPEDVWRLRTVADPRLSPDGRLVAYVVSEPDRERDGPATTVWVAPVDGSAPARRFSAGPDDGAPRWSPDGRSLAFVADRGHGPQLHLAPLDGGEPAVLTDVPHGVSQPVWSPDGRRLAYVARTGEWKAPEERSAVERNAPRVVTGLHHRFDGIGYLDERRSHLFVVRVDGGEAVQVTDGDWDDGDPEWSPDGRRLAFVSDRSASRHDEVHRDVWVLTVAASGRPGTPRRLTRGRGTASAPRWSPDGSTIAYLGHEVEDGNSAANAHLLVVDTARPSAPRSLSEPLDRTVWGVLRAPGAAHAWDRDGRSVVFVAADGGSLALYRATLDGSRPALVVGGDRQVVALDAAGGAIAFAAQWVSEPMEVYACGADGRRERRVSEANAELRRDVRFAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JU57</accession>
    <name>A0A7K0JU57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03617 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_10045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01000470">
        <property type="protein sequence ID" value="MST33059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="336" mass="36442" checksum="8BFD1CA10889D181" modified="2021-04-07" version="1">MLVDGGIPPDLAGAADGARRAEEEGYAAVWGSETSHDPFLPLALAAEHTTRLELGTGIAVAFARNPMTVASTAWDLNAYSRGRFLLGLGSQIKPHIEKRFSMRWSHPAPRMREFVSAMRAIWACWQDGTPLQFRGEYYRHTLMTPFFSPPPNQYGAPRVFLAAVGPAMTRVAGEVADGLLVHGFTTARYLREVTLPAVEAGLAASGRSRAAFQLSYPIFVVTGDTDEQLAEAASGTRKQLAFYASTPAYRAVLDLHGWGEMQPALNALSKQGRWDDMADLIPQEVLDAFAVVGEPDEVPALITERVGELVDRVSLYTPYPVADDVVARVRGGLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JUX4</accession>
    <name>A0A7K0JUX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000709">
        <property type="protein sequence ID" value="MST33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="196" mass="21733" checksum="3DAF53A418A82D82" modified="2021-04-07" version="1" fragment="single">RVGAAGRYGFDTEFHREKTYWPQLALLQFSWREGADTRAALVDPLAVPVGPLAGLLGGPATLVAHAADQDLEILQHECGTGPGTLFDTQIAAGFAGHGSASLATLTRVYLGYDLPKGDRLTDWSARPLQESQRRYAVADVAHLLDLEEAIREDLDRRGRLAWAEQECELLRLRAARPAEPDRAWWRLRDARQLRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JV15</accession>
    <name>A0A7K0JV15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XdhC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_13850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000730">
        <property type="protein sequence ID" value="MST33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="105" mass="10854" checksum="4095459DF3CC0606" modified="2021-04-07" version="1">MKEVLADIDRWRSEGKRVAVARVVGIEGSSPRLPGATMVVSDTGEVAGSVSGGCVEGAVVTEALEVLAGEGSPRLCTFGYSDDEAFAVGLTCGGTIRVLVEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVH4</accession>
    <name>A0A7K0JVH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline iminopeptidase-family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_14335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000763">
        <property type="protein sequence ID" value="MST33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="47"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST33892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="319" mass="35621" checksum="C4F21FEC5443D32A" modified="2021-04-07" version="1">MTSERYLDYGGRPDRLSGGARRIPIDTPAGTFEVWTKRVGNNPDLQLLLLHGGPGATHEYFEAADSYLPAAGVEYYYYDQLGSGRSDRPDEPLLWDLERFVDEVEQVRRALGLDRESLVVLGHSWGGILAIEYALAHQDHLRGLVISNMMASAPAYTAYAHDVLMPAMDQAVLAEILGFEQRGETDDPRYMALLFEHYYTEHTIRMPVASWPDPVARGLGNINPKIYVPMQGPSEMGMSAEASLARWDRVDDLHRIQVPTLVIGAEHDTMDPAHMAMMAGRLPDGRYLHCPQGSHLAMYDDQETYFGGLVAFLRELANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVJ6</accession>
    <name>A0A7K0JVJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000795">
        <property type="protein sequence ID" value="MST33978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="93" mass="10389" checksum="E6C218D766B36D8F" modified="2021-04-07" version="1">MVRLTGPGDGGLLYAETAYDAFAIVEGTPTSATVRCEREVRIERDEWRTRVRTVSTMSATPAEFHLTNVLEAFEGPDRVFVRAWATAVPRDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVK8</accession>
    <name>A0A7K0JVK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_14870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000802">
        <property type="protein sequence ID" value="MST33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="333" mass="36200" checksum="E252DFB87695D4C3" modified="2021-04-07" version="1" fragment="single">MHVLLTGHAGLLISTGDTTILCDPWFSPAYLGSWFPFPDNAGIDPARLAAPRYLYISHLHKDHFDRRFLAEHVDKSATVLLPEFPVDDLRAALEEVGFHRFVTTRNGVPVDLDGVRVMIVAATSPSDGPIGDSVLAVDDGECRLLNQNDCHPRDPSVLGRLGPYDLHLLQYSGAIWYPMVYRLDPGAKAELARAKRERQVARALGYIRAVGAARVVPFAGPPAFLDPALFALNDVGRDPANIFLDQPQFLDMMAAAGMDQGVLAVAGSELELAPGRLEVTHAVDPAAVWGDKAAYLRAYQERRKAQLEAERPQPALAAGRGGEDLAAALAAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JVX6</accession>
    <name>A0A7K0JVX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">moaC</name>
        <name evidence="8" type="ORF">GHK86_15425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="WJHE01000853">
        <property type="protein sequence ID" value="MST34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="7">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MST34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="206" mass="21806" checksum="E2B49188B2AE55A1" modified="2021-04-07" version="1">MSDRGLTHIDPLGRARMVDVTPKEATHRRAIARCKVFMLPETTSKVASNAMSKGDVLGAARIAGIQAAKRTAEMIPLCHPLLVGSVAINFDIRDDYVEVEAQVETVDRTGVEMEALTACAIASLTIYDMCKSADRSMTIGELALWEKTGGRSGVWRRPAGSLEEPLVNTPPPALGVTGSGASGGDGLDARIDDILAEGPTDPTADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW21</accession>
    <name>A0A7K0JW21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">GHK86_15585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000866">
        <property type="protein sequence ID" value="MST34138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="145" mass="15434" checksum="4D060F732B951F22" modified="2021-04-07" version="1">MRALVQRVVSAEVTVAGERVGRIGPGMCALVGVTHTDDAATADRLADRLWGLRVFEDGDGLTNRSVADVGGAVLVVSQFTLYADTRRGRRPSFVDAARPEVAEPLVDAVIARLRALGAEVATGRFRADMQVALVNDGPFTVMLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JW23</accession>
    <name>A0A7K0JW23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydantoinase B/oxoprolinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_15670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000874">
        <property type="protein sequence ID" value="MST34155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="2">
        <location>
            <begin position="18"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="630" mass="69217" checksum="7FB1475198D8356B" modified="2021-04-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWA6</accession>
    <name>A0A7K0JWA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000906">
        <property type="protein sequence ID" value="MST34231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029665234" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="5376" checksum="9BB1004BBF05E9F0" modified="2021-04-07" version="1">MPVVLVSVMGGAPGHTGSGASGASAANGAELVAVLVPQPDDHGVARRREAATSAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWF1</accession>
    <name>A0A7K0JWF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_16320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000927">
        <property type="protein sequence ID" value="MST34280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="281" mass="29924" checksum="C4CBACE9C22B7EDB" modified="2021-04-07" version="1" fragment="single">MVPTFVIFLREGVEASMIVAILLAYLDKLGQRRHFRDVFAGVAAAMGLVLAGGVAAYLLLASYAGSRVQTIFETATFLVAAAVLTSMTFWMQGHARSLSSELKRRTDAALDGRARWGLRILAFQAVGREGLETMVFTLAIVFASSGRGVIGGGIAGLVAALAVAFAIYRLGRRIDIGRFFTVAGAVLMVFAAALLADAVENLQQLGWLPVGAHLWNTTRALPEDGNLGDLLHVLFGYADHPTALQLGVYVLYLALAVGIFVARRPRRRRVGAATSPPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWJ1</accession>
    <name>A0A7K0JWJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_16175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000917">
        <property type="protein sequence ID" value="MST34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="75" mass="8098" checksum="DC16562E90EF37CF" modified="2021-04-07" version="1">HGDVFGSTVNVASRLGDAARPGTVLVDGRLADVLARSAGLELRRSGVRSLKGLGPVRAYLLRRRQPAADDRLDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWM4</accession>
    <name>A0A7K0JWM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_16330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000928">
        <property type="protein sequence ID" value="MST34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="252" mass="27757" checksum="924CB4FB5BBC34EE" modified="2021-04-07" version="1">MEFDALVAEGLAVPVEGWDFSWFQGRATEQRPSWGYARLLAGRLAGARSALDIQTGGGEVFAWALEQAACHPSRLTATESWSPNAVLANHRLGQLKVGVVRAADDEGLPLRDGVFDLVSSRHPVELVWSEVARVLRPGGTFLSQMVGPGSNRELYEFLMGPQPDDPSRSSQVAAADAAAVGLQLVQVQEEALDVVFFDVAAVVHFLRKVPWTVPDFTVDRYHDRLAALHAQLDQEGQFLCHSQRYLIELRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWU4</accession>
    <name>A0A7K0JWU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2397 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000996">
        <property type="protein sequence ID" value="MST34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013493">
        <property type="entry name" value="CHP02677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09660">
        <property type="entry name" value="DUF2397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="380" mass="40664" checksum="96BF364CFD0290E2" modified="2021-04-07" version="1" fragment="single">MRPVRSPRSTPAGPRAPFSTVGPMADPERLRLYAYVTAPEAEDYLAIMSAFTQALLVEWSAQDVVDHGVDLPAEVVAARCRSLAEHGNLLLSPREVRVTSIAEYQSQPARYSVSALGARLHREVEAFLAVTGGAREVPRELLALIAEGLAGLDPDGDARALAGAVSTIFAQFQDFAGSVTDFYTYIGSVLTRSDLDGDEWSGFKALLIDYLESIVESVRLHSPAIAAALARLHPRIDDVVARIGDAGFAALEASTPGGEGTQRAQGRRREDWSDLEKWFAGPGSRQLREAAHRAVGSLLSSLKRINSASTNEASLRRHFLKLAGWFDGATPAEAHVLAAAAFGAYPSRHLGVPLDADLDAAVPATASWWRSPPAPVPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWW6</accession>
    <name>A0A7K0JWW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001005">
        <property type="protein sequence ID" value="MST34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="99"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="374" mass="40634" checksum="F77BAED4E681CCBE" modified="2021-04-07" version="1">MPVVAAPGCRWWPRPGCRWWLRPGCARTPVVARVGGERRPPRYPGGVSDPTLATRAGADPARPDPLTPPDVDAVAAALEEHGYIADEGLATSIFLALVLHRPLLLEGEAGVGKTEVAKVLSAWTGGDLLRLQCYEGIDVSQAVYEWDYARQLLHLRASEVAGERAASNGRPDGAAAAEPTDAVYSERFLVRRPLLQAIDHGDGPPPVLLIDEVDRADDEFEAFLLEILSEYAVTVPELGTFHAAVPPRVIITSNRTRDVHDALKRRCLYHWVPHPDFEREVAIVRLRAPQAAPVLARQVAAAVEALRGMQLYKPPGVAETIDWATALAALGRATIDERTLDVTLGTVLKYQEDQNRVRAAGIGELVRAAVLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JWY0</accession>
    <name>A0A7K0JWY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ISAzo13 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000975">
        <property type="protein sequence ID" value="MST34382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011518">
        <property type="entry name" value="Transposase_36"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07592">
        <property type="entry name" value="DDE_Tnp_ISAZ013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="409" mass="44240" checksum="BE575E670DCF787D" modified="2021-04-07" version="1">MDGEGLSTLFARVNPHLDERQRRVLAGSVARALGRGGIVAVAEAAGMSRSTVQAAVAQVDEGMEVSDRVRAPGGGRPRLVERDPTLLSDLDSLVDPETRGDPMCPLRWTTKSTEHLAKALRGMGHTVSADTVGRLLVGMGYSLQAPAKENEGAQHPDRDAQFRYLNGQVEAHLGAGEPVISVDTKKKEVIGNLANKGREYQPKGEPVRVDVHDFPDPKLGKAIPYGVFDIGADAGFVTVGSDADTAAVAVASIGRWWDQVGSAVYPDATRLLITADAGGSNGYRSRLWKRELGSLAQRTGLAITVCHFPPGTSKWNRIEHRLFSHISMNWRGRPLTSHEVVVDLIATTTRSGLTVHAERDPGSYPKGTKVTDAELAAVPRQAHSFHGEWNYTIGGTRLTSRRRKRITTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX02</accession>
    <name>A0A7K0JX02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001028">
        <property type="protein sequence ID" value="MST34481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="67" mass="7530" checksum="8796B094F7DC5430" modified="2021-04-07" version="1" fragment="single">MAELGAFIREQRAMARMSLRRLSELAGISNPYLSQIERGLRRPSAEILQQIARGLRISAESLYVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX08</accession>
    <name>A0A7K0JX08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000992">
        <property type="protein sequence ID" value="MST34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="296" mass="31417" checksum="75AEBBBB2FEE59DF" modified="2021-04-07" version="1">SAFDRTTAQYFWRLFPPDAANGVAMALWAKQKGYTRVAVVFGTDTGSQGDKPGVVAGLKALNIPVVSDINLTPDQPTYLSSVHRLMAAHPQVIMTESDAATAGTFFGELKQLGGLVPIIGTEATFTAPWITAVKGALGSSFQQTFTSLITAPSSKTAAVTAFEQAVTADKSQVPKPWQSYLNNPFSITYWDGMVAVALAMNAAHSTKPTVFNKYIPEVTNPGPGKVVVYTYAQGVKELKAGKQIQYYGASGLIDFNQYHNSFGNQEAVGSNGSSQPVKLGTVTAKQIEAVPVTGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX48</accession>
    <name>A0A7K0JX48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_17595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001054">
        <property type="protein sequence ID" value="MST34528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="205"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="320" mass="33837" checksum="8A060555192FD44B" modified="2021-04-07" version="1" fragment="single">MSLFGHRPSFEARLSTLVALAVGVTIALAALASYLLVDHQLRGQVQSSLQSYVNTVDGTSTFDKGAAQSAVRYAASTGDRVQLILPGGQVWVPAPDGSFTPAGPGSTGFRPSGSQLAVATGHDESVLYNDQTIGEVRYRVVTIAVQATPHVAPFAQSGPRIPAALQIGRPLTDIDRALADLRLILALVTGGGVAVALVIGTMVARTTIRPVTRLTATAEHVAATQDLDATIEVDSDDELGRLAHAFNSMLTALRLSREQQAQLVSDAGHELRTPLTSLRTNIEFLMKARAMPEADRAALLTDVQDQLEELTSLVGDIVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX49</accession>
    <name>A0A7K0JX49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001015">
        <property type="protein sequence ID" value="MST34452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="101" mass="9942" checksum="F9702CE72A45FD88" modified="2021-04-07" version="1">PPDLGADLGGDGRTVGVRCPDHALIRALAAATGPLAVTSANRHGGAPFASASALAEGLDGVALVLDGGPCAGEPSTVVAVEGGEVRLLRPGALWPRVQDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JX57</accession>
    <name>A0A7K0JX57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001059">
        <property type="protein sequence ID" value="MST34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="126" mass="13502" checksum="166668979394C1B4" modified="2021-04-07" version="1">MRATRSFEPQPDQVVAARHFVAEVLAGAGHAVGDIPLLVSELATNAVLHARSDFLITVEVEQDGPGRVRVEVSDRNSRLPSFAAVKPDAYSGRGLMLVQTLSAAWGVDAHAEEGKTIWFEVHDSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXD0</accession>
    <name>A0A7K0JXD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001098">
        <property type="protein sequence ID" value="MST34611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="141" mass="15169" checksum="ACC7A62F4B624E2F" modified="2021-04-07" version="1">MQAITSHLAPRRVLGSTFELGTPFYQGVSVAVLLRAGSRSAELVRQDALERLYRFVHPTLGGRSGTGWPFGEALHTAPIAEMLRAVPGVEDVIDVLLFEYDLRGGTEAAGQRVGAGRDVIPLDEHSLFLSAHHQVVVRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXF0</accession>
    <name>A0A7K0JXF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_18105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001113">
        <property type="protein sequence ID" value="MST34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="382"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="506" mass="54392" checksum="8B43900EBED00D29" modified="2021-04-07" version="1">MQGSSDPDRRLLDAAALCRQLLPAGSVEAFLADHRQRLFPDELFADLFPSGRGRPSIPADVVATVMVLQALEGLSDRDAARALTDRISWKVAAGLALDDAGFDYSVLTYWRSRLRRSGRPERIFEVVREVVSATGVLAGRTRRALDSTLLDDAVATQDTVTQLISVIRRARREIPAAAAVPVTAHDYDRAGKPTVAWDDPVAKQALISGLVNDALAILAAVGGADLDASQQATVGLLALVAGQDVEPGESEGTWRIAERVAPDRVISTVDPESRHMHKSRSVYRDGYKAHVAVEPTTGLITNADLTPANVGDGPVGAGLLAGEAPGLQVLADSAYGSGPTRTALTAAGHTQAIKPLPLRPAVPGGFTRDNFTIDHTARTVTCPAGHSVPIAPKGGASFGRRCDGCPLRSSCTTARHGMTLQVSDHDAQLVAARRAWRDGTFIDDYRQWRPMVERSLAWTVADGWRRLRYHGVARNRQALLTRIAAINLRRLVNLGLTHTDRWALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXN8</accession>
    <name>A0A7K0JXN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_16390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="WJHE01000931">
        <property type="protein sequence ID" value="MST34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="57" mass="5713" checksum="F180E53A0E9D6249" modified="2021-04-07" version="1" fragment="single">MPDATAPETAAVRYEGAAGVATLTMAQVATRNALTAELMAGLVEGLERAAADPAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXT3</accession>
    <name>A0A7K0JXT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_18830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001205">
        <property type="protein sequence ID" value="MST34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="111" mass="12123" checksum="F2F81879F0B8206F" modified="2021-04-07" version="1" fragment="single">MVFNAWYLAWFDEAFGTFLDDGGLGYTDLVAGGTDVQLVHTEMDWRSPLRWGDDADVEVRLLAVGRHSFTVGYRVRSGERVVLDARTVYVTVGLDTGGPGTAGTLRGKVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXU9</accession>
    <name>A0A7K0JXU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
            <ecNumber evidence="2">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pafA</name>
        <name evidence="4" type="ORF">GHK86_18905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="2"/>
    <dbReference type="EMBL" id="WJHE01001212">
        <property type="protein sequence ID" value="MST34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="452" mass="52641" checksum="F935CD41575804A0" modified="2021-04-07" version="1">MDRRIFGLENEYGVTCTLRGQRRLSPDEVARYLFRRVVSWGRSSNVFLENGARLYLDVGSHPEYATPECDSISDLVVHDKAGERILENLVVSAEARLREEGIRGVIFLFKNNTDSAGNSYGCHENYLTSRRDDFSHYAEVLIPFLVSRQIYAGSGKVLQTARGAMYCISQRAEHIWEGVSSATTRSRPIINTRDEPHADAERFRRLHVIVGDSNMSEYATFLKVGATSILLRMLEDPSVVLRDMTLENPIRAIREISHDTTCRRRVRLANGREASALDIQQEYLGRAKRYQETRGLSPLEDRALEMWEHCLEGLEKDPWSLDRECDWVIKHRLIERYRERESLPLTHPRVALMDLQYHDVSRERGLFYKMQRKGLVERTCTDEDIERAIDEPPQTTRARLRGEFIRRAKERRRDFTVDWVHLKLNDQAQRTVLCKDPFKSRDERVERLIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXX5</accession>
    <name>A0A7K0JXX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GHK86_19055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="WJHE01001230">
        <property type="protein sequence ID" value="MST34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MST34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="290" mass="29111" checksum="4AB1A03AD8398153" modified="2021-04-07" version="1" fragment="single">MTAVTLVEVSPRDGLQNDPADLTTEAKVELVARVAAAGARRVEVTSFVSPRAVPKMADAEAVVAGLRARRLTGVSLIGLVVNERGVTRAAAAGVDEVNAVVVASDTFNRRNQGVPTAETLARLPDLVGAARAAGLGVSVTVGAAFGCPFEGEVPVGRLAEVVAAVAAAGPDEIALADTIGVAVPADVAERVPAAREVVGPSLRLRAHFHDTRNTAVANALAAVGLGVEALDASLGGLGGCPFAPAATGNVATEDLVYALGRSGVAHGLDLAALIEASRWLGRAVGHDLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JXZ7</accession>
    <name>A0A7K0JXZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_18795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001200">
        <property type="protein sequence ID" value="MST34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="84" mass="9303" checksum="ED152544E5780228" modified="2021-04-07" version="1" fragment="single">RPHVRERLDGLIGDYVGAFKPDTGFLEERLAGLDPTDLGSLQSALGDPASFLSEMQNDTQRRLLVPLRALLSVVTGWVDHVMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY15</accession>
    <name>A0A7K0JY15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reductase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_17015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01000994">
        <property type="protein sequence ID" value="MST34414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reductase_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST34414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="44" mass="4607" checksum="E865071394B4401D" modified="2021-04-07" version="1">AVARDVRLAERLIHRQARPSPDQLADPAVPLKDLLAAVPAGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY28</accession>
    <name>A0A7K0JY28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_19360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="WJHE01001268">
        <property type="protein sequence ID" value="MST34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="228" mass="24851" checksum="96204D4A2C70575A" modified="2021-04-07" version="1">SGLRVDHVMGLFRLYWIPEGAEPAAGTYVRYPYWDLLNILALEAHRAGAFVVGEDLGTVEDAVRAELAERRVLSYRLLWFEPERPSAWRPDALGAVTTHDLPTVAGLWTGADLEVQRRLGLDPNEEGSREIVDRLAGWGGLDPDAEPAEVVRTAYGLLAESPCRVLTVTLDDVAVVPERPNMPGTVDQWPNWSIALPVPLEELESSPLAAAVAAEMNAGPRSPGGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JY73</accession>
    <name>A0A7K0JY73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_19485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001284">
        <property type="protein sequence ID" value="MST34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="53" mass="5654" checksum="68331A11D3AF894D" modified="2021-04-07" version="1">MPAAQSAGYAQAACAAGDDVRLISLPDVDHRAVTRRHGAAWSALRSEVHRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JYA6</accession>
    <name>A0A7K0JYA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GHK86_19655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001311">
        <property type="protein sequence ID" value="MST34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MST34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="336" mass="35339" checksum="6582FE6040EB6B77" modified="2021-04-07" version="1">MAVTAGDGPAIEVHGLVKRYGKLQALAGIDLVVRRGEVFGFLGPNGAGKTTTLRILATLTRPDGGTARILGYDVVAEADAVRAKIALTGQLASLDEGLTGQENLLLIGRLRGLSRRAARRRAEVLAELFELSDAARRPVRGYSGGMRRRLDIAASLVVTPELLFLDEPTTGLDPHSRARVWELVREIAAAGTTVLLTTQYLEEADQLAEHVAVIDGGRIVAEGTSAQLKAKVGSGGLHVRVLDRRQRPEAQAVLGAALGTVVHLLPDPHALSARLSPEVEPTELGALVGRAMTELSRAQVAVATVTLGHASLDEAFLALTGRPGAGSSTDEEAAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ31</accession>
    <name>A0A7K0JZ31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GHK86_21060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001518">
        <property type="protein sequence ID" value="MST35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MST35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="193" mass="20046" checksum="1650DEF98FBA0159" modified="2021-04-07" version="1" fragment="single">MVRPPSSVRRLVRRRPGPPAPAEPIQPTGADEALLADLGAALGPDGLRVDGVERSLLSRDASVFDRGRSGPVCFPRTTAEVQGVVRAAVRHGRAVVPRGAGTGLAGGAVPLGEPVVIALTRMNHILEVDVDNRVAWVEPGVINLDLSNQLRPLGFHFAPDPSSQQACTIGGNVANNSGGPHCLAYGVTSSHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZ42</accession>
    <name>A0A7K0JZ42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001523">
        <property type="protein sequence ID" value="MST35216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="129" mass="13987" checksum="617F7774886FBC28" modified="2021-04-07" version="1">GAPVEVDDRWVEVDYGVYDGLPLREVPATVWSSWDADLEWVPEGGESLAAVARRVRAACAELWADAQRRDVAVVSHVSPIKAALGWAMGLPETTAPSLFVEVASLHRIGPGRAGPTLWSLNEVHHRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZA2</accession>
    <name>A0A7K0JZA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001600">
        <property type="protein sequence ID" value="MST35301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="100" mass="10536" checksum="7614841FD06A7613" modified="2021-04-07" version="1">RADGTVEVLDEAPGMLLGVDSPERSSAEVELRPGDCLVAYTDGLIERRGESIDTGLARVAEALACGDGADLEVVVDRLLAVDGRDRSDDTAVLAVRIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZF2</accession>
    <name>A0A7K0JZF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAK2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GHK86_21795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001654">
        <property type="protein sequence ID" value="MST35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MST35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="148" mass="15114" checksum="340CE287B67E4F5F" modified="2021-04-07" version="1" fragment="single">MTAYRDALREHQERINRLNVFPVPDGDTGTNMALTLQSVVEGLPVGPDADLAAVAQAISHGSLMGARGNSGVILSQILRGLAEAVRDSLAVDGRTLADGLGRAAAGAYKAVQKPVEGTILSVVRAAAESVAGSDAGLLEVAERARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZI6</accession>
    <name>A0A7K0JZI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GHK86_21940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001687">
        <property type="protein sequence ID" value="MST35380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MST35380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="207" mass="22209" checksum="B45E79AD5C520B75" modified="2021-04-07" version="1">MGALGLPYWLAGGQAAPGRLGDARAGGAAGIQVGSAFALCEESAMDPLLKREVIDRWFAGTLQVRTDPAASPTGFPFKVAQLPRTGAEASVYDQRPRVCDLGYLRLPYRRADATIGYRCPAEPVGAYLRKGGRLDDTVGRRCLCNGLMATIGLGQRRRGRPDEPPIVTIGQDLSFLGDLASAPDRRYRAADVLAYLLRPASPQGTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0JZK3</accession>
    <name>A0A7K0JZK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flg_hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GHK86_21825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls the length of the flagellar hook.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001661">
        <property type="protein sequence ID" value="MST35357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001635">
        <property type="entry name" value="Flag_hook_Flik"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01007">
        <property type="entry name" value="FLGHOOKFLIK"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="5">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MST35357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="113" mass="11204" checksum="2F68E1780278DBC7" modified="2021-04-07" version="1" fragment="single">MTTGAPGRPVPTPAEQLTQAVLPLATGPDGTTQVTLSLHPLDLGEVHVQVVLQASTVSVTIHAADPATRTLLAGQLGDLRTLLESSGVATGALDLGSGAGSGGQHPGWRSGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K0K044</accession>
    <name>A0A7K0K044_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GHK86_20905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acidiferrimicrobium australe</name>
        <dbReference type="NCBI Taxonomy" id="2664430"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Acidimicrobiia</taxon>
            <taxon>Acidimicrobiales</taxon>
            <taxon>Acidimicrobiaceae</taxon>
            <taxon>Acidiferrimicrobium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <title>Acidiferrimicrobium australis gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido- reduction of iron isolated from metal-rich acidic water in Chile.</title>
            <authorList>
                <person name="Gonzalez D."/>
                <person name="Huber K."/>
                <person name="Hedrich S."/>
                <person name="Rojas-Villalobos C."/>
                <person name="Quatrini R."/>
                <person name="Dinamarca M.A."/>
                <person name="Schwarz A."/>
                <person name="Canales C."/>
                <person name="Nancucheo I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">USS-CCA1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJHE01001494">
        <property type="protein sequence ID" value="MST35179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437736">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MST35179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437736"/>
        </source>
    </evidence>
    <sequence length="372" mass="37268" checksum="5FCF6D95E51084C1" modified="2021-04-07" version="1" fragment="single">AGGAPAVAAPGGVWSPGRRLLSAGLVLAITLVAFEALAIATVMPVVGRHLGDLALYGWVFSAFSLASLIGIVVAGSLADTVPLWRPMLGGLVLFAAGLVIGGTAPSMPVLVAGRVVQGLGAGVVPAVAYVAISRAYPGAIRPRMFAVLSTAWVVPGLIGPAVAAAVADAAGWRWVFLGLLPLVAAAGVLSSLALRTLPPPAAAIARRVPIVPVAGVVAGAGLALAALDAGSAVLTAPGILAGLAVLAGSLRRLTPPGTLRARRGLPATILSRGLLTFFFYAGDAYVPYAVTTVRHQPTVVAGVVLTVGTITWTAGSWLQARTIHRVGPRRLIRAGELLALSALVAMGFVILPGVPVALAVAAWGWGGLGMGM</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>